HpcH/HpaI aldolase/citrate lyase family protein similar to Salmonella enterica 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase HpcH (also known as HpaI) which may catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate to pyruvate and succinic semialdehyde
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; This model represents the aldolase which ...
6-254
8.08e-150
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; This model represents the aldolase which performs the final step unique to the 4-hydroxyphenylacetic acid catabolism pathway in which 2,4-dihydroxyhept-2-ene-1,7-dioic acid is split into pyruvate and succinate-semialdehyde. The gene for enzyme is generally found adjacent to other genes for this pathway organized into an operon.
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Pssm-ID: 131364 Cd Length: 249 Bit Score: 418.41 E-value: 8.08e-150
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; This model represents the aldolase which ...
6-254
8.08e-150
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; This model represents the aldolase which performs the final step unique to the 4-hydroxyphenylacetic acid catabolism pathway in which 2,4-dihydroxyhept-2-ene-1,7-dioic acid is split into pyruvate and succinate-semialdehyde. The gene for enzyme is generally found adjacent to other genes for this pathway organized into an operon.
Pssm-ID: 131364 Cd Length: 249 Bit Score: 418.41 E-value: 8.08e-150
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; This model represents the aldolase which ...
6-254
8.08e-150
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; This model represents the aldolase which performs the final step unique to the 4-hydroxyphenylacetic acid catabolism pathway in which 2,4-dihydroxyhept-2-ene-1,7-dioic acid is split into pyruvate and succinate-semialdehyde. The gene for enzyme is generally found adjacent to other genes for this pathway organized into an operon.
Pssm-ID: 131364 Cd Length: 249 Bit Score: 418.41 E-value: 8.08e-150
2-dehydro-3-deoxyglucarate aldolase; In E. coli this enzyme (GarL) 2-dehydro-3-deoxyglucarate ...
6-255
1.87e-92
2-dehydro-3-deoxyglucarate aldolase; In E. coli this enzyme (GarL) 2-dehydro-3-deoxyglucarate aldolase acts in the catabolism of several sugars including D-galactarate, D-glucarate and L-idarate. In fact, 5-dehydro-4-deoxy-D-glucarate aldolase is a synonym for this enzyme as it is unclear in the literature whether the enzyme acts on only one of these or, as seems likely, has no preference. (Despite the apparent large difference in substrate stucture indicated by their names, 2-DH-3DO- and 5-DH-4DO-glucarate differ only by the chirality of most central hydroxyl-bearing carbon and is alternately named 2-DH-3DO-galactarate.) The reported product of D-galactarate dehydratase (4.2.1.42) is the 5DH-4DO-glucarate isomer and this enzyme is found proximal to the aldolase in many genomes (GenProp0714) where no epimerase is known. Similarly, the product of D-glucarate dehydratase (4.2.1.40) is again the 5-DH-4DO isomer, so the provenance of the 2-DH-3DO-glucarate isomer for which this enzyme is named is unclear.
Pssm-ID: 132283 Cd Length: 249 Bit Score: 273.25 E-value: 1.87e-92
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
127-211
6.34e-03
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 37.35 E-value: 6.34e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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