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Conserved domains on  [gi|15599547|ref|NP_253041|]
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acyltransferase [Pseudomonas aeruginosa PAO1]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 40-245 7.26e-39

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 134.75  E-value: 7.26e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  40 PLRQRLTRWWLARLCAALPFEVRVSGE---APRQPMLWVANHVSWTDIPLLGALAP--LTFLSKAEVRAWPLAGWLAEKA 114
Cdd:COG0204  10 RFRYRLVRLWARLLLRLLGVRVRVEGLenlPADGPVLIVANHQSWLDILLLLAALPrpVRFVAKKELFKIPLLGWLLRAL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547 115 GTLFIRRGSGDSRL-INQRLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAISYRRDGVPDAQAP 193
Cdd:COG0204  90 GAIPVDRSKRRAALrALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLP 169

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15599547 194 FIGDddllshlgrllrgergsVHIQLLEPIPSQGL---DRAELARQAQQAVRLAL 245
Cdd:COG0204 170 RPGK-----------------VTVRIGPPIDPSDLegeDRRELAERLRAAIEALL 207
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 40-245 7.26e-39

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 134.75  E-value: 7.26e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  40 PLRQRLTRWWLARLCAALPFEVRVSGE---APRQPMLWVANHVSWTDIPLLGALAP--LTFLSKAEVRAWPLAGWLAEKA 114
Cdd:COG0204  10 RFRYRLVRLWARLLLRLLGVRVRVEGLenlPADGPVLIVANHQSWLDILLLLAALPrpVRFVAKKELFKIPLLGWLLRAL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547 115 GTLFIRRGSGDSRL-INQRLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAISYRRDGVPDAQAP 193
Cdd:COG0204  90 GAIPVDRSKRRAALrALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLP 169

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15599547 194 FIGDddllshlgrllrgergsVHIQLLEPIPSQGL---DRAELARQAQQAVRLAL 245
Cdd:COG0204 170 RPGK-----------------VTVRIGPPIDPSDLegeDRRELAERLRAAIEALL 207
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 50-242 9.70e-39

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 133.17  E-value: 9.70e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  50 LARLCAALPFEVRVSGEA---PRQPMLWVANHVSWTDIPLLGALAP--LTFLSKAEVRAWPLAGWLAEKAGTLFIRRGSG 124
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLEnlpPKGPVIIVANHQSYLDPLVLGAALPrpIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547 125 DSRL-INQRLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAISYRRDGVPDAQAPFIgdddllsh 203
Cdd:cd07989  81 RSAReALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPR-------- 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15599547 204 lgrllrgeRGSVHIQLLEPI-PSQGLDRAELARQAQQAVR 242
Cdd:cd07989 153 --------PGRVTVRIGEPIpPEGLELAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 61-181 9.17e-26

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 98.12  E-value: 9.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547    61 VRVSGE---APRQPMLWVANHVSWTDIPLLGALA-----PLTFLSKAEVRAWPLAGWLAEKAGTLFIRRGS-GDSRLINQ 131
Cdd:pfam01553   2 IEVHGLenlPRGGPAIVVANHQSYLDVLLLSLALykrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNrKDAAGTLE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 15599547   132 RLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAIS 181
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 75-182 1.07e-25

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 97.43  E-value: 1.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547     75 VANHVSWTDIPLLGALAP-----LTFLSKAEVRAWPLAGWLAEKAGTLFIRRGSG--DSRLINqRLAEQLHRGRNLLIFP 147
Cdd:smart00563   4 VANHQSFLDPLVLSALLPrklgrVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrkARAALR-EAVELLKEGEWLLIFP 82

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 15599547    148 EGTTTNGESLRTFHGRLMASALEAGVAVQPVAISY 182
Cdd:smart00563  83 EGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRG 117
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 59-181 4.72e-23

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 90.87  E-value: 4.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547    59 FEVRVSGE---APRQPMLWVANHVSWTDIPLLGAL--APLTFLSKAEVRAWPLAGWLAEKAGTLFIRRGS-GDSRLINQR 132
Cdd:TIGR00530   2 LKVEVVGPenlPAKSPVLVVANHQSNLDPLTLSAAfpPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENiRAIATALKA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 15599547   133 LAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAIS 181
Cdd:TIGR00530  82 AIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 49-180 1.26e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 59.36  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547   49 WlARLCAALPFEVRVSGE----APRQPMLWVANHVSWTDIPLLGALA-PLTFLSKAEVRAWPLAGWLAEKAGTLFIRRGS 123
Cdd:PLN02901  26 W-ATLSTSPFYKIEVEGLenlpSPDEPAVYVSNHQSFLDIYTLFHLGrPFKFISKTSIFLIPIIGWAMYMTGHIPLKRMD 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15599547  124 GDSRL-INQRLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAI 180
Cdd:PLN02901 105 RRSQLeCLKRCMELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITL 162
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 40-245 7.26e-39

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 134.75  E-value: 7.26e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  40 PLRQRLTRWWLARLCAALPFEVRVSGE---APRQPMLWVANHVSWTDIPLLGALAP--LTFLSKAEVRAWPLAGWLAEKA 114
Cdd:COG0204  10 RFRYRLVRLWARLLLRLLGVRVRVEGLenlPADGPVLIVANHQSWLDILLLLAALPrpVRFVAKKELFKIPLLGWLLRAL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547 115 GTLFIRRGSGDSRL-INQRLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAISYRRDGVPDAQAP 193
Cdd:COG0204  90 GAIPVDRSKRRAALrALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLP 169

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15599547 194 FIGDddllshlgrllrgergsVHIQLLEPIPSQGL---DRAELARQAQQAVRLAL 245
Cdd:COG0204 170 RPGK-----------------VTVRIGPPIDPSDLegeDRRELAERLRAAIEALL 207
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 50-242 9.70e-39

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 133.17  E-value: 9.70e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  50 LARLCAALPFEVRVSGEA---PRQPMLWVANHVSWTDIPLLGALAP--LTFLSKAEVRAWPLAGWLAEKAGTLFIRRGSG 124
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLEnlpPKGPVIIVANHQSYLDPLVLGAALPrpIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547 125 DSRL-INQRLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAISYRRDGVPDAQAPFIgdddllsh 203
Cdd:cd07989  81 RSAReALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPR-------- 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15599547 204 lgrllrgeRGSVHIQLLEPI-PSQGLDRAELARQAQQAVR 242
Cdd:cd07989 153 --------PGRVTVRIGEPIpPEGLELAEEDRKELREKVR 184
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 61-189 8.06e-28

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 105.77  E-value: 8.06e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  61 VRVSGEAPRQ--PMLWVANHVSWTDIPLLGALAPLTFLSKAEVRAWPLAGWLAEKAGTLFIRRGSGDSR-LINQRLAEQL 137
Cdd:cd07991  13 IKVHGKPDPPeaPRIIVANHTSFIDPLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKDRkKVVEEIKERA 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15599547 138 HRGRN--LLIFPEGTTTNGESLRTFHgrlmASALEAGVAVQPVAISYRRDGVPD 189
Cdd:cd07991  93 TDPNWppILIFPEGTTTNGKALIMFK----KGAFEPGVPVQPVAIRYPNKFVDA 142
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 61-181 9.17e-26

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 98.12  E-value: 9.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547    61 VRVSGE---APRQPMLWVANHVSWTDIPLLGALA-----PLTFLSKAEVRAWPLAGWLAEKAGTLFIRRGS-GDSRLINQ 131
Cdd:pfam01553   2 IEVHGLenlPRGGPAIVVANHQSYLDVLLLSLALykrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNrKDAAGTLE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 15599547   132 RLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAIS 181
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 75-182 1.07e-25

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 97.43  E-value: 1.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547     75 VANHVSWTDIPLLGALAP-----LTFLSKAEVRAWPLAGWLAEKAGTLFIRRGSG--DSRLINqRLAEQLHRGRNLLIFP 147
Cdd:smart00563   4 VANHQSFLDPLVLSALLPrklgrVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrkARAALR-EAVELLKEGEWLLIFP 82

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 15599547    148 EGTTTNGESLRTFHGRLMASALEAGVAVQPVAISY 182
Cdd:smart00563  83 EGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRG 117
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 59-181 4.72e-23

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 90.87  E-value: 4.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547    59 FEVRVSGE---APRQPMLWVANHVSWTDIPLLGAL--APLTFLSKAEVRAWPLAGWLAEKAGTLFIRRGS-GDSRLINQR 132
Cdd:TIGR00530   2 LKVEVVGPenlPAKSPVLVVANHQSNLDPLTLSAAfpPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENiRAIATALKA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 15599547   133 LAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAIS 181
Cdd:TIGR00530  82 AIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 47-150 3.27e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 63.41  E-value: 3.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  47 RWWLARLCAAlpfEVRVSGEAPRQP---MLWVANHVSWTDIPLL-------GALAPLTFLSKAEVRAWPLAGWLAEKAGT 116
Cdd:cd07990   1 VFLFEWLSGV---KVVVYGDEPKLPkerALIISNHRSEVDWLVLwmladrfGRLGRLKIVLKDSLKYPPLGGWGWQLGEF 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15599547 117 LFIRRGSGDSRlinQRLAEQLHR------GRNLLIFPEGT 150
Cdd:cd07990  78 IFLKRKWEKDE---KTIKRQLKRlkdspePFWLLIFPEGT 114
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 49-180 1.26e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 59.36  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547   49 WlARLCAALPFEVRVSGE----APRQPMLWVANHVSWTDIPLLGALA-PLTFLSKAEVRAWPLAGWLAEKAGTLFIRRGS 123
Cdd:PLN02901  26 W-ATLSTSPFYKIEVEGLenlpSPDEPAVYVSNHQSFLDIYTLFHLGrPFKFISKTSIFLIPIIGWAMYMTGHIPLKRMD 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15599547  124 GDSRL-INQRLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAI 180
Cdd:PLN02901 105 RRSQLeCLKRCMELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITL 162
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 105-228 6.97e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 57.20  E-value: 6.97e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547 105 PLAGWLAEKAGTLFIRRGSGDSRLINQRLAEQLH----RGRNLLIFPEGT-TTNGESLRTFHGrLMASALEA-------G 172
Cdd:cd07993  62 PILGTLLRRLGAFFIRRSFGKDPLYRAVLQEYVQellkNGQPLEFFIEGTrSRTGKLLPPKLG-LLSVVVEAylkgsvpD 140

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15599547 173 VAVQPVAISYrrDGVPDAQApFIGDD----------DLLSHLGRLLRGERGSVHIQLLEPIPSQGL 228
Cdd:cd07993 141 VLIVPVSISY--DRVLEEEL-YAEELlgppkpkeslSGLLGASKILRENFGRIRVDFGEPISLREY 203
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 49-245 1.22e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 56.50  E-value: 1.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  49 WLARLCAALPF-EVRVSGEAP---RQPMLWVANHV-SWTDIPLLGA--LAPLTFLSKAEVRAWPLAGWLAEKAGTLFIRR 121
Cdd:cd07992   3 LLSRVILRIYFrRITVVGRENvpkDGPVIFLGNHPnALIDPLLLAAtlRRPVRFLAKADLFKNPLIGWLLESFGAIPVYR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547 122 ---------GSGDSRLINQRLAEQLHRGRNLLIFPEGTTTNGESLRTFH---GRLMASALEAG---VAVQPVAISYRrdg 186
Cdd:cd07992  83 pkdlarggiGKISNAAVFDAVGEALKAGGAIGIFPEGGSHDRPRLLPLKagaARMALEALEAGqkdVKIVPVGLNYE--- 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15599547 187 vpDAQAPfigdddllshlgrllrgeRGSVHIQLLEPIPSQGLDRAELARQAQQAVRLAL 245
Cdd:cd07992 160 --DKSRF------------------RSRVLVEFGKPISVSAFEEAEASRDVEKKLINQL 198
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 61-188 7.89e-08

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 50.88  E-value: 7.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  61 VRVSGEAPRQPM-----LWVANHVSWTDIPLL------GALAPLTFLSKAE--VRAWPLAgwlaeKAGTLFIRRGSGDS- 126
Cdd:cd06551  12 VRLEVKGPPPPPgggpvLFVSNHSSWWDGLILflllerGLRRDVYGLMDEEllERYPFFT-----RLGAFSVDRDSPRSa 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599547 127 ----RLINQRLAEqlhRGRNLLIFPEGTTTNGES-LRTFHGRLMASALEAGVAVQPVAISYRRDGVP 188
Cdd:cd06551  87 akslKYVARLLSK---PGSVVWIFPEGTRTRRDKrPLQFKPGVAHLAEKAGVPIVPVALRYTFELFE 150
PLN02833 PLN02833
glycerol acyltransferase family protein
 68-182 6.75e-07

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 49.77  E-value: 6.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547   68 PRQPMLWVANHVSWTDIPLLGALAPLTFLSKAEvrawplAGWLA-------EKAGTL-FIRRGSGDSRLINQRLAEQL-H 138
Cdd:PLN02833 161 RRPKQVFVANHTSMIDFIVLEQMTPFAVIMQKH------PGWVGflqntilESVGCIwFNRTEAKDREVVAKKLRDHVqD 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 15599547  139 RGRN-LLIFPEGTTTNGESLRTFHgrlmASALEAGVAVQPVAISY 182
Cdd:PLN02833 235 PDRNpLLIFPEGTCVNNEYTVMFK----KGAFELGCTVCPIAIKY 275
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 44-180 9.09e-07

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 49.54  E-value: 9.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547    44 RLTRWWLARLCaalpFEVRVSGEA--PRQ-PMLWVANHVSWTDIPLLGALAP--LTFLSKAEVRAWPLAGWLAEKAGTLF 118
Cdd:PRK08633  416 RFLLLLLMHTR----YRLRVEGREniPAKgGALLLGNHVSWIDWALLQAASPrpIRFVMERSIYEKWYLKWFFKLFGVIP 491

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599547   119 IrrGSGDSRLINQRLAEQLHRGRNLLIFPEGTTTNGESLRTFHGRLMASALEAGVAVQPVAI 180
Cdd:PRK08633  492 I--SSGGSKESLEFIRKALDDGEVVCIFPEGAITRNGQLNEFKRGFELIVKGTDVPIIPFYI 551
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 104-184 8.79e-05

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 43.37  E-value: 8.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547 104 WPLaGWLAEKAGTLFIRRGSGDSRL----INQRLAEQLHRGRNLLIFPEGtttnGESlRTfhGRLMA----------SAL 169
Cdd:COG2937 243 WPL-GPILRRGGAFFIRRSFKGNKLysavFREYLAELFERGYSVEYFIEG----GRS-RT--GRLLPpktgmlsmtvQAF 314

                        90
                ....*....|....*....
gi 15599547 170 EAG----VAVQPVAISYRR 184
Cdd:COG2937 315 LRGarrpVVFVPVYIGYER 333
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 44-184 4.95e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 39.51  E-value: 4.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599547  44 RLTRWwlarlcaalpfevRVSGEAPRQP--MLWVANHVSWTD--IPLLGALA---PLTFLSKAEVRAWPLaGWLAEKAGT 116
Cdd:cd07988   6 RLSGW-------------RIEGEPPNKPkfVVIGAPHTSNWDfvLGLLAAFAlglKISFLGKHSLFKPPL-GPFMRWLGG 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599547 117 LFIRRGSGDS------RLINQRlaEQLhrgrNLLIFPEGTTTNGESLRT-FHgRLmasALEAGVAVQPVAISYRR 184
Cdd:cd07988  72 IPVDRSRAGGlveqvvEEFRRR--EEF----VLAIAPEGTRSKVDKWKTgFY-HI---ARGAGVPILLVYLDYKR 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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