|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
4-1506 |
6.83e-168 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 547.76 E-value: 6.83e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 4 LRRFSRSLAVAALVLLPFAAVQAEDTVEPSGYTPMAGESFFLLADSSFATDEEARVRLEAPGRDYRRYRMEPYGGVDVRL 83
Cdd:COG2373 9 LTPPLLLAALAALALLALLALLLGAALPLSPPPALALAIAALVLPAAPLLALLLAPLLLALAAAASALALAATLLALSLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 84 YRIE-QPLEFLKRQKNLHRVLAEGQFKGEGLSNTLAYLWDNWYRKSRRVMQRAFSYESRQQVTEAVPELKMGNAMTAPTP 162
Cdd:COG2373 89 SAAAlLLLALLAALALAVRAAALAASSALAAAAAALALAAALLAAALLALLAALAAAAALALALALAAAAAAALAALLAA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 163 YDAQPQYAPIPGLPLVSQFRYPLWDAKPIEPPQDVKLAGSSSEF-INVVPG---NVYIPLGKL----KPGLYLVEA---- 230
Cdd:COG2373 169 AAAALLALAALAAELAALLALALVLAAALLAPAALSEVALLLEPdLKGKLNkrvTTALPLSELlallKPGVYLVVArfpg 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 231 ---LVGKYRATTVVFVSNSVAVSKVAGDELLVWTARKHEGTPVPDTKVLWTDGLG-VMSSGNTDADGLLRLKHASPERS- 305
Cdd:COG2373 249 dysYNGESRATQWFLVSDLGLTAKRGDDGLLVFVTSLSTGKPVAGAEVELYDRNGqVLATATTDADGLARFPAGDRGEGg 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 306 ----YVI---GEDR------EGGVFVSENFYYDSEI--YDTKIYAFTDRPLYRPGDWVSLKMVGREFKDARQSQAaasaP 370
Cdd:COG2373 329 rapaLLVarkGGDFafldldDGPALDLSDFDVGGRAppGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGL----P 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 371 VRLSVIDASGTVLQSLDLRFDAKSGANGRFQLPENAVAGGYELRF--DYRGQTYSSAFRVAEYIKPHFEVALDLAKPDFK 448
Cdd:COG2373 405 LTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELyvDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLK 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 449 TAEPVKGEIVLLYPDGKPVANARLQLSLRAQQLSMV--DNE-----LQYLGQFPVELSSTELTTDGKGRAAIELPPAE-- 519
Cdd:COG2373 485 PGDPVTVTVDARYLFGAPAAGLKVEGEVTLRPARTAfpGYPgyrfgDPDEEFEPEELDLGEGTLDADGKASLSLPLPDap 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 520 ---KPSRYMLTIFASDGAAYRVKTSKEILIERGAARYRLSAPQ-RFSAAGEKVEFSY----ASEQPTPLKPSSYQWIRLE 591
Cdd:COG2373 565 dapGPLRATVEASVFESGGRPVTRSATVPVHPADFYVGIRLPLfDGDPEGAPATFEVvavdPDGKPVAGKGLKVELYREE 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 592 --------------------DRATDSGPVA-----DGRFALTFERPGTYSVELRDDKGQLLGATGHSVSGEGVKSV--PG 644
Cdd:COG2373 645 wryvwyksddggwryesqekEEPVAEGTLTtgadgPASLSLTPVEWGRYRLEVKDPDGGLATSVRFYAGGNASWGAerPD 724
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 645 TVEVVFDKPEYRTGEEASALITFPEPVEdALLSLERDKVEatallskgadWLRLEKLNPTQYRVWIPVREEFSPNLTFSV 724
Cdd:COG2373 725 RLELSLDKESYKPGETAKLLIQSPFAGR-ALVTVERDGVL----------ETQWVDVKGGGTTVEIPVTEDWAPNAYVSA 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 725 LYTKGGD--------YSFQNAGIKVGMP--QVEIDIATDKErYEPGETVTVTL-ATRFAGKPVssHLTVSVVDEMVYALQ 793
Cdd:COG2373 794 TLVRPGDstandmpaRAYGVAPLPVDPParRLKVELTAPEK-LRPGETLTVTVkVKGAAGKAA--EVTLAAVDEGILNLT 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 794 AEIAPGIDQFFYHPRRNNVRTSASlafisYDVALPGSTSAPGRAN---RSERGVKVLERPRREDV-DTAAWQPELVTDAQ 869
Cdd:COG2373 871 GYKTPDPLDFFYGKRALGVETRDL-----YGRLIGAFGGAAGALRsggDGALGRGGNPKPPRKRFkPVALFSGPVKTDAD 945
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 870 GKASFSFRMPDSLTRWRITARAIDDnGQVGQKKQFLRSEKPLYLKWSGPTRFRQGDQPDLGLFVFNQGEQPVKAEL---L 946
Cdd:COG2373 946 GKATVSFDLPDFNGTLRVMAVAWSD-DRFGSAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVtleA 1024
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 947 SGP--PGSQRSQTLELAKG---VNYIPLAQQPLSDGDWSAELRQDGQvRDRLAVRFNLLADGWQVEQMQNLSLAAASN-- 1019
Cdd:COG2373 1025 SGGltLEGEATQTVTLAAGgraTVRFPLKAPDAGDAKVTVTATGGGE-SDAREVELPVRPANPLVTRATSGVLAPGESwt 1103
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1020 -PLQLPADAR----DVRLRLADGPAAAYLGNLDDLLEYPYGGVEQTASQLLPLSIAYPAL--AGGEPRIRDRLRLIMQNS 1092
Cdd:COG2373 1104 lPLDLPGGLRpgtgSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAeaLGLKGDKDAELRARIQAA 1183
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1093 RLRLVQMAGPDAWFAWWGGDVDGDAFLTayayyadwyaS---------RALEIQLPAEHWQRILEPYAKQATQTPLLQ-- 1161
Cdd:COG2373 1184 IARLLSMQNSDGGFGLWPGGSESDPWLT----------AyatdflleaREAGYAVPDDALDRALDYLRNYLRNPWEIEyd 1253
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1162 ----------RALILAFARDMQLpvntllgGLLNDLANagegqaRAEPLEADDGLVLgdpdsaVGLAAARVLAVDLARQL 1231
Cdd:COG2373 1254 dayrlavrayALYVLARAGKADL-------GDLRYLYD------RRKDALSPLAKAQ------LAAALALLGDKARAEEL 1314
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1232 RVAVPAPLAAQAETATQR------LREAGLpftdAL-LASRSAVDGQQASALLQRLAPA------QSTLERALALTWLQG 1298
Cdd:COG2373 1315 LAAALARLRETGARDYWYgdygspLRDQAL----ALaLLAELGPDAPLAPKLARWLAKAlksgrwLSTQETAWALLALAA 1390
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1299 ALAQApqgklpQPPKDWQAQRGASGET--------YWQWR---GRGIPSWVDLDEAPARPLPVALSYR----SAQAPSGQ 1363
Cdd:COG2373 1391 YARAA------GASPDFTATLTLDGKTlpltgrgpLARVTlpaAELLAGPLTITNTGDGPLYYTLTLSgypaEGPPPAAS 1464
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1364 LPVQISRRLLRLVPgegafefkvEEVGDKPLSSDELYLDEVTLNVPEDtALRYGMLELPLPPGADVERTTWGIkISGLAG 1443
Cdd:COG2373 1465 NGLEIERRYYDLDG---------KPIDPASLKQGDLVVVRLTVTAPSG-RVENVAVVDPLPAGFEIENPRLAT-SGDLGD 1533
|
1610 1620 1630 1640 1650 1660
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599685 1444 DEATTLERARNEPGELFYGVPVD-SLSGEQRFRHLVRFSQKGSFNLPPARYLRLYAPEQQALEA 1506
Cdd:COG2373 1534 WLGDSWQPDHQEFRDDRVVAAFDlDPAGTYTFAYLVRAVTPGTFVLPPAQAEDMYRPEVRARSA 1597
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
857-945 |
2.51e-26 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 104.21 E-value: 2.51e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 857 TAAWQPELVTDaQGKASFSFRMPDSLTRWRITARAIDDNGQVGQKKQF-LRSEKPLYLKWSGPTRFRQGDQPDLGLFVFN 935
Cdd:pfam00207 1 TWLWDPVLVTD-NGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPeLVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|
gi 15599685 936 QGEQPVKAEL 945
Cdd:pfam00207 80 YLDKCLKVRV 89
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1043-1302 |
2.89e-12 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 68.95 E-value: 2.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1043 LGNLDDLLEYPYGGVEQTASQLLPLSIAYPALA---GGEPRIRDRLRLIMQNSRLRLVQMAGPDAWFAWWGGDVDGDAFL 1119
Cdd:cd02891 2 LGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDatgQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTWL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1120 T-----------AYAYYADWYASRALEI----QLPAEHWQRiLEPYAKQATQTPLLQRALILAFArdmqlpVNTLLggLL 1184
Cdd:cd02891 82 TayvvkflsqarKYIDVDENVLARALGWlvpqQKEDGSFRE-LGPVIHREMKGGVDDSVSLTAYV------LIALA--EA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1185 NDLANAGEGQARAEpLEADDGLVLgDPDSAVGLAAARVLAVDLARQLRVavpapLAAQAETATQRLREAGLPFTD----- 1259
Cdd:cd02891 153 GKACDASIEKALAY-LETQLDGLL-DPYALAILAYALALAGDSTRADEA-----LKKLLEAAREKGGTAHWSLSWpgdyg 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1260 ----------ALLASRSAVDGQQASALLQRLAPAQ-------STLERALALTwlqgALAQ 1302
Cdd:cd02891 226 sslrveatayALLALLKLGDLEEAGPIAKWLAQQRnsgggflSTQDTVVALQ----ALAA 281
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
4-1506 |
6.83e-168 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 547.76 E-value: 6.83e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 4 LRRFSRSLAVAALVLLPFAAVQAEDTVEPSGYTPMAGESFFLLADSSFATDEEARVRLEAPGRDYRRYRMEPYGGVDVRL 83
Cdd:COG2373 9 LTPPLLLAALAALALLALLALLLGAALPLSPPPALALAIAALVLPAAPLLALLLAPLLLALAAAASALALAATLLALSLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 84 YRIE-QPLEFLKRQKNLHRVLAEGQFKGEGLSNTLAYLWDNWYRKSRRVMQRAFSYESRQQVTEAVPELKMGNAMTAPTP 162
Cdd:COG2373 89 SAAAlLLLALLAALALAVRAAALAASSALAAAAAALALAAALLAAALLALLAALAAAAALALALALAAAAAAALAALLAA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 163 YDAQPQYAPIPGLPLVSQFRYPLWDAKPIEPPQDVKLAGSSSEF-INVVPG---NVYIPLGKL----KPGLYLVEA---- 230
Cdd:COG2373 169 AAAALLALAALAAELAALLALALVLAAALLAPAALSEVALLLEPdLKGKLNkrvTTALPLSELlallKPGVYLVVArfpg 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 231 ---LVGKYRATTVVFVSNSVAVSKVAGDELLVWTARKHEGTPVPDTKVLWTDGLG-VMSSGNTDADGLLRLKHASPERS- 305
Cdd:COG2373 249 dysYNGESRATQWFLVSDLGLTAKRGDDGLLVFVTSLSTGKPVAGAEVELYDRNGqVLATATTDADGLARFPAGDRGEGg 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 306 ----YVI---GEDR------EGGVFVSENFYYDSEI--YDTKIYAFTDRPLYRPGDWVSLKMVGREFKDARQSQAaasaP 370
Cdd:COG2373 329 rapaLLVarkGGDFafldldDGPALDLSDFDVGGRAppGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGL----P 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 371 VRLSVIDASGTVLQSLDLRFDAKSGANGRFQLPENAVAGGYELRF--DYRGQTYSSAFRVAEYIKPHFEVALDLAKPDFK 448
Cdd:COG2373 405 LTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELyvDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLK 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 449 TAEPVKGEIVLLYPDGKPVANARLQLSLRAQQLSMV--DNE-----LQYLGQFPVELSSTELTTDGKGRAAIELPPAE-- 519
Cdd:COG2373 485 PGDPVTVTVDARYLFGAPAAGLKVEGEVTLRPARTAfpGYPgyrfgDPDEEFEPEELDLGEGTLDADGKASLSLPLPDap 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 520 ---KPSRYMLTIFASDGAAYRVKTSKEILIERGAARYRLSAPQ-RFSAAGEKVEFSY----ASEQPTPLKPSSYQWIRLE 591
Cdd:COG2373 565 dapGPLRATVEASVFESGGRPVTRSATVPVHPADFYVGIRLPLfDGDPEGAPATFEVvavdPDGKPVAGKGLKVELYREE 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 592 --------------------DRATDSGPVA-----DGRFALTFERPGTYSVELRDDKGQLLGATGHSVSGEGVKSV--PG 644
Cdd:COG2373 645 wryvwyksddggwryesqekEEPVAEGTLTtgadgPASLSLTPVEWGRYRLEVKDPDGGLATSVRFYAGGNASWGAerPD 724
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 645 TVEVVFDKPEYRTGEEASALITFPEPVEdALLSLERDKVEatallskgadWLRLEKLNPTQYRVWIPVREEFSPNLTFSV 724
Cdd:COG2373 725 RLELSLDKESYKPGETAKLLIQSPFAGR-ALVTVERDGVL----------ETQWVDVKGGGTTVEIPVTEDWAPNAYVSA 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 725 LYTKGGD--------YSFQNAGIKVGMP--QVEIDIATDKErYEPGETVTVTL-ATRFAGKPVssHLTVSVVDEMVYALQ 793
Cdd:COG2373 794 TLVRPGDstandmpaRAYGVAPLPVDPParRLKVELTAPEK-LRPGETLTVTVkVKGAAGKAA--EVTLAAVDEGILNLT 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 794 AEIAPGIDQFFYHPRRNNVRTSASlafisYDVALPGSTSAPGRAN---RSERGVKVLERPRREDV-DTAAWQPELVTDAQ 869
Cdd:COG2373 871 GYKTPDPLDFFYGKRALGVETRDL-----YGRLIGAFGGAAGALRsggDGALGRGGNPKPPRKRFkPVALFSGPVKTDAD 945
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 870 GKASFSFRMPDSLTRWRITARAIDDnGQVGQKKQFLRSEKPLYLKWSGPTRFRQGDQPDLGLFVFNQGEQPVKAEL---L 946
Cdd:COG2373 946 GKATVSFDLPDFNGTLRVMAVAWSD-DRFGSAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVtleA 1024
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 947 SGP--PGSQRSQTLELAKG---VNYIPLAQQPLSDGDWSAELRQDGQvRDRLAVRFNLLADGWQVEQMQNLSLAAASN-- 1019
Cdd:COG2373 1025 SGGltLEGEATQTVTLAAGgraTVRFPLKAPDAGDAKVTVTATGGGE-SDAREVELPVRPANPLVTRATSGVLAPGESwt 1103
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1020 -PLQLPADAR----DVRLRLADGPAAAYLGNLDDLLEYPYGGVEQTASQLLPLSIAYPAL--AGGEPRIRDRLRLIMQNS 1092
Cdd:COG2373 1104 lPLDLPGGLRpgtgSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAeaLGLKGDKDAELRARIQAA 1183
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1093 RLRLVQMAGPDAWFAWWGGDVDGDAFLTayayyadwyaS---------RALEIQLPAEHWQRILEPYAKQATQTPLLQ-- 1161
Cdd:COG2373 1184 IARLLSMQNSDGGFGLWPGGSESDPWLT----------AyatdflleaREAGYAVPDDALDRALDYLRNYLRNPWEIEyd 1253
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1162 ----------RALILAFARDMQLpvntllgGLLNDLANagegqaRAEPLEADDGLVLgdpdsaVGLAAARVLAVDLARQL 1231
Cdd:COG2373 1254 dayrlavrayALYVLARAGKADL-------GDLRYLYD------RRKDALSPLAKAQ------LAAALALLGDKARAEEL 1314
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1232 RVAVPAPLAAQAETATQR------LREAGLpftdAL-LASRSAVDGQQASALLQRLAPA------QSTLERALALTWLQG 1298
Cdd:COG2373 1315 LAAALARLRETGARDYWYgdygspLRDQAL----ALaLLAELGPDAPLAPKLARWLAKAlksgrwLSTQETAWALLALAA 1390
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1299 ALAQApqgklpQPPKDWQAQRGASGET--------YWQWR---GRGIPSWVDLDEAPARPLPVALSYR----SAQAPSGQ 1363
Cdd:COG2373 1391 YARAA------GASPDFTATLTLDGKTlpltgrgpLARVTlpaAELLAGPLTITNTGDGPLYYTLTLSgypaEGPPPAAS 1464
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1364 LPVQISRRLLRLVPgegafefkvEEVGDKPLSSDELYLDEVTLNVPEDtALRYGMLELPLPPGADVERTTWGIkISGLAG 1443
Cdd:COG2373 1465 NGLEIERRYYDLDG---------KPIDPASLKQGDLVVVRLTVTAPSG-RVENVAVVDPLPAGFEIENPRLAT-SGDLGD 1533
|
1610 1620 1630 1640 1650 1660
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599685 1444 DEATTLERARNEPGELFYGVPVD-SLSGEQRFRHLVRFSQKGSFNLPPARYLRLYAPEQQALEA 1506
Cdd:COG2373 1534 WLGDSWQPDHQEFRDDRVVAAFDlDPAGTYTFAYLVRAVTPGTFVLPPAQAEDMYRPEVRARSA 1597
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
857-945 |
2.51e-26 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 104.21 E-value: 2.51e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 857 TAAWQPELVTDaQGKASFSFRMPDSLTRWRITARAIDDNGQVGQKKQF-LRSEKPLYLKWSGPTRFRQGDQPDLGLFVFN 935
Cdd:pfam00207 1 TWLWDPVLVTD-NGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPeLVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|
gi 15599685 936 QGEQPVKAEL 945
Cdd:pfam00207 80 YLDKCLKVRV 89
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
646-792 |
4.68e-17 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 79.32 E-value: 4.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 646 VEVVFDKPEYRTGEEASALITFPEPVEDallslERDKVEATaLLSKGadWLRLEKLNPTQYRVWIPVREEFSPNLTFSVL 725
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTV-----ERDGFTYL-VLSKG--QIVVVGRGGVTTSFSLPVTAEMAPSARVVAY 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599685 726 Y----TKGGDYSFQNAGIKVGMP---QVEIDIATDKerYEPGETVTVTLATrfagkPVSSHLTVSVVDEMVYAL 792
Cdd:pfam07703 73 YvrvdLSKPEVVADSVWVDVDDTcenKLKVTLSAEK--YRPGSTVELKVKA-----DPGAYVALAAVDKGVLLL 139
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
332-428 |
6.92e-17 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 77.36 E-value: 6.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 332 KIYAFTDRPLYRPGDWVSLKMVGREfkdaRQSQAAASAPVRLSVIDASGTVLQSLDLRFDAKSGANGRFQLPENAVAGGY 411
Cdd:pfam01835 1 RAFVYTDRGIYRPGETVHFKGLLRD----QDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTY 76
|
90
....*....|....*....
gi 15599685 412 ELRF--DYRGQTYSSAFRV 428
Cdd:pfam01835 77 TVVLrdGAGGSLGSGSFRV 95
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1043-1302 |
2.89e-12 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 68.95 E-value: 2.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1043 LGNLDDLLEYPYGGVEQTASQLLPLSIAYPALA---GGEPRIRDRLRLIMQNSRLRLVQMAGPDAWFAWWGGDVDGDAFL 1119
Cdd:cd02891 2 LGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDatgQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTWL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1120 T-----------AYAYYADWYASRALEI----QLPAEHWQRiLEPYAKQATQTPLLQRALILAFArdmqlpVNTLLggLL 1184
Cdd:cd02891 82 TayvvkflsqarKYIDVDENVLARALGWlvpqQKEDGSFRE-LGPVIHREMKGGVDDSVSLTAYV------LIALA--EA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1185 NDLANAGEGQARAEpLEADDGLVLgDPDSAVGLAAARVLAVDLARQLRVavpapLAAQAETATQRLREAGLPFTD----- 1259
Cdd:cd02891 153 GKACDASIEKALAY-LETQLDGLL-DPYALAILAYALALAGDSTRADEA-----LKKLLEAAREKGGTAHWSLSWpgdyg 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1260 ----------ALLASRSAVDGQQASALLQRLAPAQ-------STLERALALTwlqgALAQ 1302
Cdd:cd02891 226 sslrveatayALLALLKLGDLEEAGPIAKWLAQQRnsgggflSTQDTVVALQ----ALAA 281
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
1136-1511 |
1.01e-05 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 50.64 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1136 IQLPAEHWQRILEPYAKQATQTPLLQRALILAFARDMQLPVNTLLGGLLNDLANAGEGQARAEPLEADDGLVLGDPDSAV 1215
Cdd:COG3321 861 VPLPTYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAA 940
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1216 GLAAARVLAVDLARQLRVAVPAPLAAQAETATQRLREAGLPFTDALLASRSAVDGQQASALLQRLAPAQSTLERALALTW 1295
Cdd:COG3321 941 ALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAA 1020
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1296 LQGALAQAPQGKLPQPpkDWQAQRGASGETYWQWRGRGIPSWVDLDEAPARPLPVALSYRSAQAPSGQLPVQISRRLLRL 1375
Cdd:COG3321 1021 LLALAALLAAAAAALA--AAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALA 1098
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1376 VPGEGAFEFKVEEVGDKPLSSDELYLDEVTLNVPEDTALRYGMLELPLPPGADVERTTWGIKISGLAGDEATTLERARNE 1455
Cdd:COG3321 1099 LAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALA 1178
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15599685 1456 PGELFYGVPVDSLSGEQRFRHLVRFSQKGSFNLPPARYLRLYAPEQQALEAKPALA 1511
Cdd:COG3321 1179 LALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALA 1234
|
|
| EntF |
COG1020 |
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ... |
1132-1381 |
1.17e-04 |
|
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 47.16 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1132 RALEIQLPAEHWQRILEPYAKQATQTPLLQRALILAFARDMQLPVNTLLGGLLNDLANAGEGQARAEPLEADDGLVLGDP 1211
Cdd:COG1020 2 AAAAAAALPPAAAAAPLPLSAAQQRLWLLLLLLLGSAAYNLALALLLLGLLLVAALLLLAALLARRRRALRTRLRTRAGR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1212 DSAVGLAAARVLAVDLARQLRVAVPAPLAAQAETATQRLREAGLPFTDALLASRSAVDGQQASALLQRLAPAQSTLERAL 1291
Cdd:COG1020 82 PVQVIQPVVAAPLPVVVLLVDLEALAEAAAEAAAAAEALAPFDLLRGPLLRLLLLLLLLLLLLLLLALHHIISDGLSDGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1292 ALTWLQGALAQAPQGKLPQPP--------------KDWQAQRGASGETYWQWRGRGIPswVDLDEAPARPLPVALSYRSA 1357
Cdd:COG1020 162 LLAELLRLYLAAYAGAPLPLPplpiqyadyalwqrEWLQGEELARQLAYWRQQLAGLP--PLLELPTDRPRPAVQSYRGA 239
|
250 260
....*....|....*....|....
gi 15599685 1358 QApSGQLPVQISRRLLRLVPGEGA 1381
Cdd:COG1020 240 RV-SFRLPAELTAALRALARRHGV 262
|
|
| COG3903 |
COG3903 |
Predicted ATPase [General function prediction only]; |
1014-1381 |
2.12e-03 |
|
Predicted ATPase [General function prediction only];
Pssm-ID: 443109 [Multi-domain] Cd Length: 933 Bit Score: 42.70 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1014 LAAASNPLQLPADARDVRLRLADGPAAAYLGNLDDLLEYPYGGVEQTASQLLPLSIAYPALAGGEPRIRDRLRLIMQNSR 1093
Cdd:COG3903 529 RAALRWALAHGDAELALRLAAALAPFWFLRGLLREGRRWLERALAAAGEAAAALAAAAALAAAAAAARAAAAAAAAAAAA 608
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1094 LRLVQMAGPDAWFAWWGGDVDGDAFLTAYAYYADWYASRALEIQLPAEHWQRILEPYAKQATQTPLLQRALILAFARDMQ 1173
Cdd:COG3903 609 AAAAAAAAAAAAAALLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAAALA 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1174 LPVNTLLGGLLNDLANAGEGQARAEPLEADDGLVLGDPDSAVGLAAARVLAVDLARQLRVAVPAPLAAQAETATQRLREA 1253
Cdd:COG3903 689 AAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAAAAAAAALALAAAAAAAAAAAAAAALAAAAA 768
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1254 GLPFTDALLASRSAVDGQQASALLQRLAPAQSTLERALALTWLQGALAQAPQGKLPQPPKDWQAQRGASGETYWQWRGRG 1333
Cdd:COG3903 769 AAALAALLLALAAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAALAAALAAAAAAAAAAAAAA 848
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15599685 1334 IPSWVDLDEAPARPLPVALSYRSAQAPSGQLPVQISRRLLRLVPGEGA 1381
Cdd:COG3903 849 AAAAALAAALAAAAAAAAAAALAAAAAAAAAAAAALLAAAAAAAAAAA 896
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
1043-1120 |
5.05e-03 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 40.61 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1043 LGNLDDLLEYPYGG--------VEQTASQLLPLSIA--YPALAGGEPRIRDRLRLIMQnsrlRLVQMAGPDAWFAWWGGD 1112
Cdd:cd00688 2 EKHLKYLLRYPYGDghwyqslcGEQTWSTAWPLLALllLLAATGIRDKADENIEKGIQ----RLLSYQLSDGGFSGWGGN 77
|
....*...
gi 15599685 1113 VDGDAFLT 1120
Cdd:cd00688 78 DYPSLWLT 85
|
|
| bMG10 |
pfam17973 |
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
1366-1500 |
6.48e-03 |
|
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9.
Pssm-ID: 465598 Cd Length: 128 Bit Score: 38.44 E-value: 6.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1366 VQISRRLLRLV-PGEGAFEFKVEEVGDKplssdelYLDEVTLNVPEDtaLRYGMLELPLPPGADVERTTWGiKISGLAGD 1444
Cdd:pfam17973 2 LSVTRRFYVLEgSGVSASDAETLKVGDK-------VRVRLTVTTDRD--RDFVALEDPLPAGLEPVNPLSG-YTWEGGLG 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599685 1445 EATTLERARNEPGE---LFYgvpVDSLS-GEQRFRHLVRFSQKGSFNLPPARYLRLYAPE 1500
Cdd:pfam17973 72 YPDNTQPSYREVRDdrvRFF---ADYLPkGTYTFEYLVRAVTPGTFTVPPATAESMYAPE 128
|
|
| |
