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Conserved domains on  [gi|15599716|ref|NP_253210|]
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chemotaxis transducer [Pseudomonas aeruginosa PAO1]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
147-673 1.33e-80

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 265.35  E-value: 1.33e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 147 GARAEKLLGSAQVFIKLLIAQAGLSQDSQRQVRQLSELVGSITPEVTAAISKGRAIGAYSLGQGFLNSSSSARLDELLLE 226
Cdd:COG0840   9 ALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLAL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 227 FEKLHGEYGLKLQESLAGSPQLLEEAAQASRETLKSLGQLFEDRVIVAETLDTPWTQFYDQVSVAMDKTYQLDDAVLGYL 306
Cdd:COG0840  89 LLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLE 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 307 DTQLQKRLQQVRTQMLLLVAALAVVFAAILYLYGGFYVSTRatLKDLGRMMERVAGGDMTVSFQARSRDELGELGQSFNE 386
Cdd:COG0840 169 AAALALAAAALALALLAAALLALVALAIILALLLSRSITRP--LRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNR 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 387 SVAKIHDLIERVSQTVGEVERQTLRVESVSAESNQAVAGQRSQIEQVATAMNQMAATAQEVARSAAMAVSSANSVNQETL 466
Cdd:COG0840 247 MIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAE 326

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 467 SGRSLVESQVGSIQRLAGEIDQSVAAINRLASDSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVR 546
Cdd:COG0840 327 EGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVR 406

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 547 TLAKRTQQSTAEIEQMILRLQGGVDAAVKAMGSSHHTADGTVNESAQVQQALENILGAVGMIVDQNQQIAAAAEQQTAVA 626
Cdd:COG0840 407 KLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGT 486

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*..
gi 15599716 627 HDIDQNIVEINQAGERTAEGASQTERASRELGAQVTQLKRLIGAFRV 673
Cdd:COG0840 487 EEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
147-673 1.33e-80

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 265.35  E-value: 1.33e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 147 GARAEKLLGSAQVFIKLLIAQAGLSQDSQRQVRQLSELVGSITPEVTAAISKGRAIGAYSLGQGFLNSSSSARLDELLLE 226
Cdd:COG0840   9 ALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLAL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 227 FEKLHGEYGLKLQESLAGSPQLLEEAAQASRETLKSLGQLFEDRVIVAETLDTPWTQFYDQVSVAMDKTYQLDDAVLGYL 306
Cdd:COG0840  89 LLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLE 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 307 DTQLQKRLQQVRTQMLLLVAALAVVFAAILYLYGGFYVSTRatLKDLGRMMERVAGGDMTVSFQARSRDELGELGQSFNE 386
Cdd:COG0840 169 AAALALAAAALALALLAAALLALVALAIILALLLSRSITRP--LRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNR 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 387 SVAKIHDLIERVSQTVGEVERQTLRVESVSAESNQAVAGQRSQIEQVATAMNQMAATAQEVARSAAMAVSSANSVNQETL 466
Cdd:COG0840 247 MIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAE 326

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 467 SGRSLVESQVGSIQRLAGEIDQSVAAINRLASDSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVR 546
Cdd:COG0840 327 EGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVR 406

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 547 TLAKRTQQSTAEIEQMILRLQGGVDAAVKAMGSSHHTADGTVNESAQVQQALENILGAVGMIVDQNQQIAAAAEQQTAVA 626
Cdd:COG0840 407 KLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGT 486

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*..
gi 15599716 627 HDIDQNIVEINQAGERTAEGASQTERASRELGAQVTQLKRLIGAFRV 673
Cdd:COG0840 487 EEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 412-672 3.35e-58

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 197.12  E-value: 3.35e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716    412 VESVSAESNQAVAGQRSQIEQVATAMNQMAATAQEVARSAAMAVSSANSVNQETLSGRSLVESQVGSIQRLAGEIDQSVA 491
Cdd:smart00283   2 VSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716    492 AINRLASDSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQGGVD 571
Cdd:smart00283  82 AVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETN 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716    572 AAVKAMGSSHHTADGTVNESAQVQQALENILGAVGMIVDQNQQIAAAAEQQTAVAHDIDQNIVEINQAGERTAEGASQTE 651
Cdd:smart00283 162 EAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEIS 241

                          250       260
                   ....*....|....*....|.
gi 15599716    652 RASRELGAQVTQLKRLIGAFR 672
Cdd:smart00283 242 AAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 438-610 5.10e-46

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 162.02  E-value: 5.10e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 438 NQMAATAQEVARSAAMAVSSANSVNQETLSGRSLVESQVGSIQRLAGEIDQSVAAINRLASDSASISQVLDVIKGIAEQT 517
Cdd:cd11386   1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 518 NLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQGGVDAAVKAMGSSHHTADGTVNESAQVQQA 597
Cdd:cd11386  81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                       170
                ....*....|...
gi 15599716 598 LENILGAVGMIVD 610
Cdd:cd11386 161 FEEIVASVEEVAD 173
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 485-638 2.16e-33

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 126.01  E-value: 2.16e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716   485 EIDQSVAAINRLASDSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMIL 564
Cdd:pfam00015  17 EVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALII 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599716   565 RLQGGVDAAVKAMGSSHHTADGTVNESAQVQQALENILGAVGMIVDQNQQIAAAAEQQTAVAHDIDQNIVEINQ 638
Cdd:pfam00015  97 EIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQ 170
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 335-673 1.30e-30

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 127.04  E-value: 1.30e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  335 ILYLYGGFYVSTRATLKDLGRMM---ERVAGGDMTVSFQARSRDELGELGQSFNESVAKIHDLIERVSQTVGEVERQTLR 411
Cdd:PRK15048 202 VLILLVAWYGIRRMLLTPLAKIIahiREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTRE 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  412 VESVSAESNQAVAGQRSQIEQVATAMNQMAATAQEVARSAAMAVSSANSVNQETLSGRSLVESQVGSIQRLAGEidqsva 491
Cdd:PRK15048 282 IAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADS------ 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  492 ainrlasdSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQGGVD 571
Cdd:PRK15048 356 --------SKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVD 427

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  572 AAVKAMGSSHHTADGTVNESAQVQqaleNILGAVGMIVDqnqqiaaaaeqqtAVAHDIDQNIVEINQAGERTAEGAS--- 648
Cdd:PRK15048 428 TGSVLVESAGETMNNIVNAVTRVT----DIMGEIASASD-------------EQSRGIDQVALAVSEMDRVTQQNASlvq 490

                        330       340
                 ....*....|....*....|....*
gi 15599716  649 QTERASRELGAQVTQLKRLIGAFRV 673
Cdd:PRK15048 491 ESAAAAAALEEQASRLTQAVSAFRL 515
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
147-673 1.33e-80

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 265.35  E-value: 1.33e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 147 GARAEKLLGSAQVFIKLLIAQAGLSQDSQRQVRQLSELVGSITPEVTAAISKGRAIGAYSLGQGFLNSSSSARLDELLLE 226
Cdd:COG0840   9 ALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLAL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 227 FEKLHGEYGLKLQESLAGSPQLLEEAAQASRETLKSLGQLFEDRVIVAETLDTPWTQFYDQVSVAMDKTYQLDDAVLGYL 306
Cdd:COG0840  89 LLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLE 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 307 DTQLQKRLQQVRTQMLLLVAALAVVFAAILYLYGGFYVSTRatLKDLGRMMERVAGGDMTVSFQARSRDELGELGQSFNE 386
Cdd:COG0840 169 AAALALAAAALALALLAAALLALVALAIILALLLSRSITRP--LRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNR 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 387 SVAKIHDLIERVSQTVGEVERQTLRVESVSAESNQAVAGQRSQIEQVATAMNQMAATAQEVARSAAMAVSSANSVNQETL 466
Cdd:COG0840 247 MIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAE 326

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 467 SGRSLVESQVGSIQRLAGEIDQSVAAINRLASDSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVR 546
Cdd:COG0840 327 EGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVR 406

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 547 TLAKRTQQSTAEIEQMILRLQGGVDAAVKAMGSSHHTADGTVNESAQVQQALENILGAVGMIVDQNQQIAAAAEQQTAVA 626
Cdd:COG0840 407 KLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGT 486

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*..
gi 15599716 627 HDIDQNIVEINQAGERTAEGASQTERASRELGAQVTQLKRLIGAFRV 673
Cdd:COG0840 487 EEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 412-672 3.35e-58

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 197.12  E-value: 3.35e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716    412 VESVSAESNQAVAGQRSQIEQVATAMNQMAATAQEVARSAAMAVSSANSVNQETLSGRSLVESQVGSIQRLAGEIDQSVA 491
Cdd:smart00283   2 VSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716    492 AINRLASDSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQGGVD 571
Cdd:smart00283  82 AVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETN 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716    572 AAVKAMGSSHHTADGTVNESAQVQQALENILGAVGMIVDQNQQIAAAAEQQTAVAHDIDQNIVEINQAGERTAEGASQTE 651
Cdd:smart00283 162 EAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEIS 241

                          250       260
                   ....*....|....*....|.
gi 15599716    652 RASRELGAQVTQLKRLIGAFR 672
Cdd:smart00283 242 AAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 438-610 5.10e-46

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 162.02  E-value: 5.10e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 438 NQMAATAQEVARSAAMAVSSANSVNQETLSGRSLVESQVGSIQRLAGEIDQSVAAINRLASDSASISQVLDVIKGIAEQT 517
Cdd:cd11386   1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 518 NLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQGGVDAAVKAMGSSHHTADGTVNESAQVQQA 597
Cdd:cd11386  81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                       170
                ....*....|...
gi 15599716 598 LENILGAVGMIVD 610
Cdd:cd11386 161 FEEIVASVEEVAD 173
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 485-638 2.16e-33

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 126.01  E-value: 2.16e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716   485 EIDQSVAAINRLASDSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMIL 564
Cdd:pfam00015  17 EVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALII 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599716   565 RLQGGVDAAVKAMGSSHHTADGTVNESAQVQQALENILGAVGMIVDQNQQIAAAAEQQTAVAHDIDQNIVEINQ 638
Cdd:pfam00015  97 EIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQ 170
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 335-673 1.30e-30

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 127.04  E-value: 1.30e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  335 ILYLYGGFYVSTRATLKDLGRMM---ERVAGGDMTVSFQARSRDELGELGQSFNESVAKIHDLIERVSQTVGEVERQTLR 411
Cdd:PRK15048 202 VLILLVAWYGIRRMLLTPLAKIIahiREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTRE 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  412 VESVSAESNQAVAGQRSQIEQVATAMNQMAATAQEVARSAAMAVSSANSVNQETLSGRSLVESQVGSIQRLAGEidqsva 491
Cdd:PRK15048 282 IAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADS------ 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  492 ainrlasdSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQGGVD 571
Cdd:PRK15048 356 --------SKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVD 427

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  572 AAVKAMGSSHHTADGTVNESAQVQqaleNILGAVGMIVDqnqqiaaaaeqqtAVAHDIDQNIVEINQAGERTAEGAS--- 648
Cdd:PRK15048 428 TGSVLVESAGETMNNIVNAVTRVT----DIMGEIASASD-------------EQSRGIDQVALAVSEMDRVTQQNASlvq 490

                        330       340
                 ....*....|....*....|....*
gi 15599716  649 QTERASRELGAQVTQLKRLIGAFRV 673
Cdd:PRK15048 491 ESAAAAAALEEQASRLTQAVSAFRL 515
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
335-673 1.09e-27

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 118.13  E-value: 1.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  335 ILYLYGGFYVSTRATLKDLGRMMERVAGGDMTVSFQARSRDELGELGQSfnesvakIHDLIERVSQTVGEVERQTLRVES 414
Cdd:PRK15041 207 IFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSNEMGQLAES-------LRHMQGELMRTVGDVRNGANAIYS 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  415 VSAESNQAVAGQRSQIEQVATAMNQMAATAQEVArsaamAVSSANSVNQETLSGRSLVESQVGsiQRLAGEIDQSVAAIN 494
Cdd:PRK15041 280 GASEIATGNNDLSSRTEQQAASLEETAASMEQLT-----ATVKQNAENARQASHLALSASETA--QRGGKVVDNVVQTMR 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  495 RLASDSASISQVLDVIKGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQGGVDAAV 574
Cdd:PRK15041 353 DISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGS 432

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  575 KAMGSSHHTADGTVNESAQVQqaleNILGAVGMIVDqnqqiaaaaeqqtAVAHDIDQ---NIVEINQAGERTAEGASQTE 651
Cdd:PRK15041 433 TLVESAGETMAEIVSAVTRVT----DIMGEIASASD-------------EQSRGIDQvglAVAEMDRVTQQNAALVEESA 495

                        330       340
                 ....*....|....*....|..
gi 15599716  652 RASRELGAQVTQLKRLIGAFRV 673
Cdd:PRK15041 496 AAAAALEEQASRLTEAVAVFRI 517
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
353-673 1.15e-21

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 99.38  E-value: 1.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  353 LGRMMERVAGGDMTVSFQARSRDELGELgqsfnesVAKIHDLIERVSQTVGEVERQTLRVESVSAESNQAVAGQRSQIEQ 432
Cdd:PRK09793 221 IGSHFDSIAAGNLARPIAVYGRNEITAI-------FASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQ 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  433 VATAMNQMAATAQEVarSAAMAVSSANSVNQETLSGRSLVESQVGSIQrlageIDQSVAAINRLASDSASISQVLDVIKG 512
Cdd:PRK09793 294 QAASLAQTAASMEQL--TATVGQNADNARQASELAKNAATTAQAGGVQ-----VSTMTHTMQEIATSSQKIGDIISVIDG 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  513 IAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAE----IEQMILRLQGG---VDAAVKAMgsshhtad 585
Cdd:PRK09793 367 IAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEikglIEESVNRVQQGsklVNNAAATM-------- 438

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716  586 gtvnesaqvqqalENILGAVGMIVDQNQQIAAAAEQQTAVAHDIDQNIVEINQAGERTAEGASQTERASRELGAQVTQLK 665
Cdd:PRK09793 439 -------------TDIVSSVTRVNDIMGEIASASEEQRRGIEQVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLS 505


                 ....*...
gi 15599716  666 RLIGAFRV 673
Cdd:PRK09793 506 SRVAVFTL 513
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 350-391 1.23e-07

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 48.21  E-value: 1.23e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15599716 350 LKDLGRMMERVAGGDMTVSFQARSRDELGELGQSFNESVAKI 391
Cdd:cd06225   4 LRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 338-425 3.93e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 49.58  E-value: 3.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 338 LYGGFYVSTRAT--LKDLGRMMERVAGGDMTVSFQARSRDELGELGQSFNESVAKIHDLIErvsqtvgEVERQTLRVESV 415
Cdd:COG5000  23 LWLALLLARRLTrpLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQRE-------ELEERRRYLETI 95

                        90
                ....*....|
gi 15599716 416 SAESNQAVAG 425
Cdd:COG5000  96 LENLPAGVIV 105
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
350-396 1.48e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 42.62  E-value: 1.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 15599716    350 LKDLGRMMERVAGGDMTVSFQARSRDELGELGQSFNESVAKIHDLIE 396
Cdd:smart00304   7 LRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
HAMP pfam00672
HAMP domain;
350-393 1.52e-05

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 42.61  E-value: 1.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15599716   350 LKDLGRMMERVAGGDMTVSFQARSRDELGELGQSFNESVAKIHD 393
Cdd:pfam00672  10 LRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
120-673 7.15e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 45.87  E-value: 7.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 120 VAEFEAQRDRLLNGLQAVEAEGSLQGKGARAEKLLGSAQVFIKLLIAQAGLSQDSQRQVRQLSELVGSITPEVTAAISKG 199
Cdd:COG2770  10 LLLLLLLLLLLLAGALLVLALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 200 RAIGAYSLGQGFLNSSSSARLDELLLEFEKLHGEYGLKLQESLAGSPQLLEEAAQASRETLKSLGQLFEDRVIVAETLDT 279
Cdd:COG2770  90 LLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALG 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 280 PWTQFYDQVSVAMDKTYQLDDAVLGYLDTQLQKRLQQVRTQMLLLVAALAVVFAAILYLYGGFYVSTRATLKDLGRMMER 359
Cdd:COG2770 170 AGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARR 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 360 VAGGDMTVSFQARSRDELGELGQSFNESVAKIHDLIERVSQTVGEVERQTLRVESVSAESNQAVAGQRSQIEQVATAMNQ 439
Cdd:COG2770 250 IAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALL 329

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 440 MAATAQEVARSAAMAVSSANSVNQETLSGRSLVESQVGSIQRLAGEIDQSVAAINRLASDSASISQVLDVIKGIAEQTNL 519
Cdd:COG2770 330 LELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELAL 409

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 520 LALNAAIEAARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQGGVDAAVKAMGSSHHTADGTVNESAQVQQALE 599
Cdd:COG2770 410 EELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALEL 489

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599716 600 NILGAVGMIVDQNQQIAAAAEQQTAVAHDIDQNIVEINQAGERTAEGASQTERASRELGAQVTQLKRLIGAFRV 673
Cdd:COG2770 490 LLLEEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAVEA 563
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
335-400 3.95e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 43.47  E-value: 3.95e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599716 335 ILYLYGGFYVSTRAT--LKDLGRMMERVAGGDMtVSFQARSRDELGELGQSFNESVAKIHDLIERVSQ 400
Cdd:COG2972 168 LLALLLSYLLSRSITrpIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYE 234
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 370-473 1.01e-03

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 41.50  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716    370 QARSRDELGELGQSFNEsVAKIHDLIERVSQTVGEVERQTLRVESVSAESNQAVAGQRSQIEQVATAMNQMAATAQEVAR 449
Cdd:smart00283 157 QEETNEAVAAMEESSSE-VEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAA 235

                           90       100
                   ....*....|....*....|....
gi 15599716    450 SAAMAVSSANSVNQETLSGRSLVE 473
Cdd:smart00283 236 MSEEISAAAEELSGLAEELDELVE 259
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 372-491 2.94e-03

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 39.96  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716    372 RSRDELGELGQSFNESVAKIHDLIERVSQTVGEVERQTLRVEsvsaESNQAVAGQRSQIEQVATAMNQMAATAQEVARSA 451
Cdd:smart00283 141 RSAESAKEIESLIKEIQEETNEAVAAMEESSSEVEEGVELVE----ETGDALEEIVDSVEEIADLVQEIAAATDEQAAGS 216

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 15599716    452 ---AMAVSSANSVNQETLSGRSLVESQVGSIQRLAGEIDQSVA 491
Cdd:smart00283 217 eevNAAIDEIAQVTQETAAMSEEISAAAEELSGLAEELDELVE 259
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
347-386 4.17e-03

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 40.00  E-value: 4.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 15599716  347 RATLKDLGRMME---RVAGGDMTVSFQARSRDELGELGQSFNE 386
Cdd:PRK10549 186 RGLLAPVKRLVEgthKLAAGDFTTRVTPTSRDELGRLAQDFNQ 228
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 371-567 6.22e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 6.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 371 ARSRDELGELGQSFNESVAKIHDLIERVSQTVGEVERQTLRVESVS---AESNQAVAGQRSQIEQVATAMNQMAATAQEV 447
Cdd:COG1196 270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEerlEELEEELAELEEELEELEEELEELEEELEEA 349

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599716 448 ARSAAMAVSSANSVNQETLsgrSLVESQVGSIQRLAGEIDQSVAAINRLASDSASISQVLDVIKGIAEQTNLLALNAAIE 527
Cdd:COG1196 350 EEELEEAEAELAEAEEALL---EAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15599716 528 AARAGEQGRGFAVVADEVRTLAKRTQQSTAEIEQMILRLQ 567
Cdd:COG1196 427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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