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Conserved domains on  [gi|15599841|ref|NP_253335|]
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uracil phosphoribosyltransferase [Pseudomonas aeruginosa PAO1]

Protein Classification

uracil phosphoribosyltransferase( domain architecture ID 10011262)

uracil phosphoribosyltransferase catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

EC:  2.4.2.9
Gene Ontology:  GO:0004845|GO:0006223
PubMed:  17384901|9628859

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 1-208 4.06e-130

uracil phosphoribosyltransferase; Reviewed


:

Pssm-ID: 234653  Cd Length: 209  Bit Score: 364.41  E-value: 4.06e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841    1 MPVHEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKISGKKITVVPILRAG 80
Cdd:PRK00129   2 MKVHVVDHPLIQHKLTLLRDKNTSTKRFRELLEELGRLLAYEATRDLPLEEVEIETPLGKTTGKRIAGKKLVIVPILRAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841   81 IGMLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLV 160
Cdd:PRK00129  82 LGMVDGVLKLIPSARVGHIGLYRDEETLEPVEYYVKLPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLCLV 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 15599841  161 AAPEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGTK 208
Cdd:PRK00129 162 AAPEGIKALEEAHPDVEIYTAAIDEKLNEHGYIVPGLGDAGDRLFGTK 209
 
Name Accession Description Interval E-value
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 1-208 4.06e-130

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 364.41  E-value: 4.06e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841    1 MPVHEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKISGKKITVVPILRAG 80
Cdd:PRK00129   2 MKVHVVDHPLIQHKLTLLRDKNTSTKRFRELLEELGRLLAYEATRDLPLEEVEIETPLGKTTGKRIAGKKLVIVPILRAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841   81 IGMLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLV 160
Cdd:PRK00129  82 LGMVDGVLKLIPSARVGHIGLYRDEETLEPVEYYVKLPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLCLV 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 15599841  161 AAPEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGTK 208
Cdd:PRK00129 162 AAPEGIKALEEAHPDVEIYTAAIDEKLNEHGYIVPGLGDAGDRLFGTK 209
Upp COG0035
Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil ...
 2-208 6.73e-120

Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439805  Cd Length: 209  Bit Score: 338.58  E-value: 6.73e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841   2 PVHEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKISGKKITVVPILRAGI 81
Cdd:COG0035   3 RVHVVDHPLIQHKLTLLRDKNTDTKEFRRLLEELGRLLAYEATRDLPLEEVEVETPLGKTTGKVLAGKKLVIVPILRAGL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841  82 GMLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVA 161
Cdd:COG0035  83 GMLDGVLDLLPSARVGHIGLYRDEETLEPVEYYFKLPEDLEGRTVIVLDPMLATGGSLVAAIDLLKKRGAKDIKIVCLIA 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15599841 162 APEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGTK 208
Cdd:COG0035 163 APEGIERVQEAHPDVDIYTAAIDEELNEKGYIVPGLGDAGDRLFGTK 209
upp TIGR01091
uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees ...
 3-208 1.08e-117

uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees separates this mostly prokaryotic set of uracil phosphoribosyltransferases from a mostly eukaryotic set that includes uracil phosphoribosyltransferase, uridine kinases, and other, uncharacterized proteins. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273438  Cd Length: 207  Bit Score: 333.06  E-value: 1.08e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841     3 VHEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKISGKKITVVPILRAGIG 82
Cdd:TIGR01091   2 VVVVDHPLIKHKLTLLRDKNTDTKEFRELLRELGRLLAYEATRDLELEEVEVETPLGETEGGRILGKKIVLVPILRAGLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841    83 MLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVAA 162
Cdd:TIGR01091  82 MVDGVLKLIPEAKVGHVGAYRNEETLKPVPYYSKLPEDIDERTVIVLDPMLATGGTMIAALDLLKKRGPKKIKVLSIVAA 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 15599841   163 PEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGTK 208
Cdd:TIGR01091 162 PEGIEAVEKAHPDVDIYTAAIDEKLNDNGYIVPGLGDAGDRAFGTK 207
UPRTase pfam14681
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ...
 8-207 1.64e-83

Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.


Pssm-ID: 434124  Cd Length: 204  Bit Score: 246.25  E-value: 1.64e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841     8 HPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKI-SGKKITVVPILRAGIGMLDG 86
Cdd:pfam14681   2 HPLLKHLLTILRDKSTSGPDFRFASDRIGRLLAYEALRDLPTEEVTVETPLGTTYAGVLfDEKKICGVPILRAGEGMEDG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841    87 VLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKE--IRAMVLVAAPE 164
Cdd:pfam14681  82 LRDLLPGARVGHIGIQRDEETLQPVEYYNKLPKDISDRTVILLDPMLATGGSAIAAIQVLREHGVPEenIVVLSVIAAPE 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 15599841   165 GIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGT 207
Cdd:pfam14681 162 GLHRLAAAFPDVKIVTAAVDEELNENGYIVPGLGDAGDRLFGT 204
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 68-182 1.18e-17

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 75.51  E-value: 1.18e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841  68 GKKITVVPILRAGIGMLDGVLSL--IPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDL 145
Cdd:cd06223  14 LEPDVVVGILRGGLPLAAALARAlgLPLAFIRKERKGPGRTPSEPYGLELPLGGDVKGKRVLLVDDVIATGGTLLAAIEL 93

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15599841 146 LKKAGSKEIRAMVLVAAPEGIEAVRKAHPDVIIYTAS 182
Cdd:cd06223  94 LKEAGAKVVGVAVLLDKPEGGARELASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 1-208 4.06e-130

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 364.41  E-value: 4.06e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841    1 MPVHEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKISGKKITVVPILRAG 80
Cdd:PRK00129   2 MKVHVVDHPLIQHKLTLLRDKNTSTKRFRELLEELGRLLAYEATRDLPLEEVEIETPLGKTTGKRIAGKKLVIVPILRAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841   81 IGMLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLV 160
Cdd:PRK00129  82 LGMVDGVLKLIPSARVGHIGLYRDEETLEPVEYYVKLPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLCLV 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 15599841  161 AAPEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGTK 208
Cdd:PRK00129 162 AAPEGIKALEEAHPDVEIYTAAIDEKLNEHGYIVPGLGDAGDRLFGTK 209
Upp COG0035
Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil ...
 2-208 6.73e-120

Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439805  Cd Length: 209  Bit Score: 338.58  E-value: 6.73e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841   2 PVHEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKISGKKITVVPILRAGI 81
Cdd:COG0035   3 RVHVVDHPLIQHKLTLLRDKNTDTKEFRRLLEELGRLLAYEATRDLPLEEVEVETPLGKTTGKVLAGKKLVIVPILRAGL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841  82 GMLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVA 161
Cdd:COG0035  83 GMLDGVLDLLPSARVGHIGLYRDEETLEPVEYYFKLPEDLEGRTVIVLDPMLATGGSLVAAIDLLKKRGAKDIKIVCLIA 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15599841 162 APEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGTK 208
Cdd:COG0035 163 APEGIERVQEAHPDVDIYTAAIDEELNEKGYIVPGLGDAGDRLFGTK 209
upp TIGR01091
uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees ...
 3-208 1.08e-117

uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees separates this mostly prokaryotic set of uracil phosphoribosyltransferases from a mostly eukaryotic set that includes uracil phosphoribosyltransferase, uridine kinases, and other, uncharacterized proteins. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273438  Cd Length: 207  Bit Score: 333.06  E-value: 1.08e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841     3 VHEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKISGKKITVVPILRAGIG 82
Cdd:TIGR01091   2 VVVVDHPLIKHKLTLLRDKNTDTKEFRELLRELGRLLAYEATRDLELEEVEVETPLGETEGGRILGKKIVLVPILRAGLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841    83 MLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVAA 162
Cdd:TIGR01091  82 MVDGVLKLIPEAKVGHVGAYRNEETLKPVPYYSKLPEDIDERTVIVLDPMLATGGTMIAALDLLKKRGPKKIKVLSIVAA 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 15599841   163 PEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGTK 208
Cdd:TIGR01091 162 PEGIEAVEKAHPDVDIYTAAIDEKLNDNGYIVPGLGDAGDRAFGTK 207
UPRTase pfam14681
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ...
 8-207 1.64e-83

Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.


Pssm-ID: 434124  Cd Length: 204  Bit Score: 246.25  E-value: 1.64e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841     8 HPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKI-SGKKITVVPILRAGIGMLDG 86
Cdd:pfam14681   2 HPLLKHLLTILRDKSTSGPDFRFASDRIGRLLAYEALRDLPTEEVTVETPLGTTYAGVLfDEKKICGVPILRAGEGMEDG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841    87 VLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKE--IRAMVLVAAPE 164
Cdd:pfam14681  82 LRDLLPGARVGHIGIQRDEETLQPVEYYNKLPKDISDRTVILLDPMLATGGSAIAAIQVLREHGVPEenIVVLSVIAAPE 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 15599841   165 GIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGT 207
Cdd:pfam14681 162 GLHRLAAAFPDVKIVTAAVDEELNENGYIVPGLGDAGDRLFGT 204
PLN02541 PLN02541
uracil phosphoribosyltransferase
 8-207 1.78e-56

uracil phosphoribosyltransferase


Pssm-ID: 215297  Cd Length: 244  Bit Score: 179.21  E-value: 1.78e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841    8 HPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKD-LPLEQYEIPGWAGPVTVEKIS-GKKITVVPILRAGIGMLD 85
Cdd:PLN02541  39 HPLIKHWLSVLRNEQTPPPIFRSAMAELGRLLIYEASRDwLPTMTGEVQTPMGVADVEFIDpREPVAVVPILRAGLVLLE 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841   86 GVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAE-RRSLIIDPMLATGGSMVATIDLLKKAG--SKEIRAMVLVAA 162
Cdd:PLN02541 119 HASSVLPATKTYHLGFVRDEETLQPSMYLNKLPDKFPEgSRVLVVDPMLATGGTIVAAIDELVSRGasVEQIRVVCAVAA 198

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 15599841  163 PEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGT 207
Cdd:PLN02541 199 PPALKKLSEKFPGLHVYAGIIDEEVNEKGYIVPGLGDAGDRSFGT 243
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 68-182 1.18e-17

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 75.51  E-value: 1.18e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841  68 GKKITVVPILRAGIGMLDGVLSL--IPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDL 145
Cdd:cd06223  14 LEPDVVVGILRGGLPLAAALARAlgLPLAFIRKERKGPGRTPSEPYGLELPLGGDVKGKRVLLVDDVIATGGTLLAAIEL 93

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15599841 146 LKKAGSKEIRAMVLVAAPEGIEAVRKAHPDVIIYTAS 182
Cdd:cd06223  94 LKEAGAKVVGVAVLLDKPEGGARELASPGDPVYSLFT 130
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 41-171 5.36e-14

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 66.62  E-value: 5.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841    41 YEATKDLPLEQYEIPGWAGPVtVEKISGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLaPD 120
Cdd:pfam00156   2 VDEILDNPAILKAVARLAAQI-NEDYGGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDTSEVMKTSSAL-PD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15599841   121 IAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVAAPEGIEAVRK 171
Cdd:pfam00156  80 LKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDK 130
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 120-158 2.90e-05

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 43.89  E-value: 2.90e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15599841 120 DIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMV 158
Cdd:COG0462 208 DVEGKTCIIVDDMIDTGGTLVEAAEALKEAGAKSVYAAA 246
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 115-179 5.33e-05

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 43.02  E-value: 5.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841  115 EKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIramvLVAAP-----EGIEAVRKAHPDVIIY 179
Cdd:PRK06827 256 EFLGRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKI----IVAATfgfftNGLEKFDKAYEEGYFD 321
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 125-150 6.21e-04

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 38.90  E-value: 6.21e-04
                         10        20
                 ....*....|....*....|....*.
gi 15599841  125 RSLIIDPMLATGGSMVATIDLLKKAG 150
Cdd:PRK02304 116 RVLIVDDLLATGGTLEAAIKLLERLG 141
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 112-154 8.85e-04

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 39.13  E-value: 8.85e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15599841  112 TYLEK--LAP----------DIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEI 154
Cdd:PRK00934 181 DYLEKtrISPteveiapknlDVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKV 235
PLN02293 PLN02293
adenine phosphoribosyltransferase
 125-164 1.67e-03

adenine phosphoribosyltransferase


Pssm-ID: 177930  Cd Length: 187  Bit Score: 38.12  E-value: 1.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 15599841  125 RSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVAAPE 164
Cdd:PLN02293 127 RALVIDDLIATGGTLCAAINLLERAGAEVVECACVIELPE 166
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 117-175 2.02e-03

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 37.13  E-value: 2.02e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15599841 117 LAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVAAPEGieavrKAHPD 175
Cdd:COG2236  82 LDEDLAGKRVLIVDDVADTGRTLEAVRDLLKEAGPAEVRTAVLYYKPSS-----KFKPD 135
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 127-164 2.55e-03

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 37.36  E-value: 2.55e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15599841 127 LIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVAAPE 164
Cdd:COG0503 116 LIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFLIELGF 153
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
120-166 6.41e-03

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 36.85  E-value: 6.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 15599841  120 DIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEiramVLVAAPEGI 166
Cdd:PRK03092 198 DVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKD----VIIAATHGV 240
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 116-183 8.90e-03

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 36.21  E-value: 8.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599841  116 KLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVL--VAAPEGIEAVRKAHPDVIIYTASI 183
Cdd:PLN02369 195 NLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACAThaVFSPPAIERLSSGLFQEVIVTNTI 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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