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Conserved domains on  [gi|15599859|ref|NP_253353|]
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methyl transferase [Pseudomonas aeruginosa PAO1]

Protein Classification

HemK/PrmC family methyltransferase( domain architecture ID 11483836)

HemK/PrmC family methyltransferase is a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; such as peptide chain release factor N(5)-glutamine methyltransferase that methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0003676|GO:0032259|GO:1904047
PubMed:  12741815|12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-274 6.10e-128

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


:

Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 364.48  E-value: 6.10e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859    1 MTTICTLLKDSQLPDSpSARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLD 80
Cdd:PRK09328   1 MMTIAEALREATARLA-SPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGLD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   81 LEVAPHTLIPRPDTELLVET-ALATLAADTATVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLEN 159
Cdd:PRK09328  80 FKVSPGVLIPRPETEELVEWaLEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGAR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  160 VEVRRSHWFSALDGRRFRMIVGNPPYIPASDPHLSEGDVR-FEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHG 238
Cdd:PRK09328 160 VEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEIG 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 15599859  239 YDQGAAVRELLGARGFAGVHTLRDLGGNERITLGQW 274
Cdd:PRK09328 240 YDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-274 6.10e-128

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 364.48  E-value: 6.10e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859    1 MTTICTLLKDSQLPDSpSARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLD 80
Cdd:PRK09328   1 MMTIAEALREATARLA-SPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGLD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   81 LEVAPHTLIPRPDTELLVET-ALATLAADTATVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLEN 159
Cdd:PRK09328  80 FKVSPGVLIPRPETEELVEWaLEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGAR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  160 VEVRRSHWFSALDGRRFRMIVGNPPYIPASDPHLSEGDVR-FEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHG 238
Cdd:PRK09328 160 VEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEIG 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 15599859  239 YDQGAAVRELLGARGFAGVHTLRDLGGNERITLGQW 274
Cdd:PRK09328 240 YDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 22-271 1.56e-126

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 359.86  E-value: 1.56e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859    22 DTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLDLEVAPHTLIPRPDTELLVETA 101
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   102 LATLAADTAtVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALDGRRFRMIVG 181
Cdd:TIGR03534  81 LERLKKGPR-VLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   182 NPPYIPASDPHLSEGDVR-FEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHGYDQGAAVRELLGARGFAGVHTL 260
Cdd:TIGR03534 160 NPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETR 239

                         250
                  ....*....|.
gi 15599859   261 RDLGGNERITL 271
Cdd:TIGR03534 240 KDLAGKDRVVL 250
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 15-275 1.88e-119

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 342.90  E-value: 1.88e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  15 DSPSARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLDLEVAPHTLIPRPDT 94
Cdd:COG2890  18 GVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFYGLEFKVDPGVLIPRPET 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  95 ELLVETA-LATLAADTATVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLEN-VEVRRSHWFSALD 172
Cdd:COG2890  98 EELVELAlALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEPLP 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 173 GR-RFRMIVGNPPYIPASDPHLSEGDVR-FEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHGYDQGAAVRELLG 250
Cdd:COG2890 178 GDgRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGEDQGEAVRALLE 257

                       250       260
                ....*....|....*....|....*
gi 15599859 251 ARGFAGVHTLRDLGGNERITLGQWA 275
Cdd:COG2890 258 AAGFADVETHKDLAGRDRVVVARRP 282
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 112-235 1.93e-17

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 77.63  E-value: 1.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALDGRRFRMIVGNPPYipasdp 191
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVEDGKFDLIISNPPF------ 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 15599859   192 HlsegdvrfepksalvAGSDGLDDI-RQIVAQAPRHLLDEGWLLL 235
Cdd:pfam05175 109 H---------------AGLATTYNVaQRFIADAKRHLRPGGELWI 138
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 112-236 8.61e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.83  E-value: 8.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTGAIALALAsERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALD--GRRFRMIVGNPPYIPas 189
Cdd:cd02440   2 VLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeaDESFDVIISDPPLHH-- 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15599859 190 dphlsegdvrfepksalvagsdGLDDIRQIVAQAPRHLLDEGWLLLE 236
Cdd:cd02440  79 ----------------------LVEDLARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-274 6.10e-128

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 364.48  E-value: 6.10e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859    1 MTTICTLLKDSQLPDSpSARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLD 80
Cdd:PRK09328   1 MMTIAEALREATARLA-SPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGLD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   81 LEVAPHTLIPRPDTELLVET-ALATLAADTATVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLEN 159
Cdd:PRK09328  80 FKVSPGVLIPRPETEELVEWaLEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGAR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  160 VEVRRSHWFSALDGRRFRMIVGNPPYIPASDPHLSEGDVR-FEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHG 238
Cdd:PRK09328 160 VEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEIG 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 15599859  239 YDQGAAVRELLGARGFAGVHTLRDLGGNERITLGQW 274
Cdd:PRK09328 240 YDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 22-271 1.56e-126

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 359.86  E-value: 1.56e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859    22 DTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLDLEVAPHTLIPRPDTELLVETA 101
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   102 LATLAADTAtVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALDGRRFRMIVG 181
Cdd:TIGR03534  81 LERLKKGPR-VLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   182 NPPYIPASDPHLSEGDVR-FEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHGYDQGAAVRELLGARGFAGVHTL 260
Cdd:TIGR03534 160 NPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETR 239

                         250
                  ....*....|.
gi 15599859   261 RDLGGNERITL 271
Cdd:TIGR03534 240 KDLAGKDRVVL 250
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 15-275 1.88e-119

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 342.90  E-value: 1.88e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  15 DSPSARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLDLEVAPHTLIPRPDT 94
Cdd:COG2890  18 GVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFYGLEFKVDPGVLIPRPET 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  95 ELLVETA-LATLAADTATVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLEN-VEVRRSHWFSALD 172
Cdd:COG2890  98 EELVELAlALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEPLP 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 173 GR-RFRMIVGNPPYIPASDPHLSEGDVR-FEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHGYDQGAAVRELLG 250
Cdd:COG2890 178 GDgRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGEDQGEAVRALLE 257

                       250       260
                ....*....|....*....|....*
gi 15599859 251 ARGFAGVHTLRDLGGNERITLGQWA 275
Cdd:COG2890 258 AAGFADVETHKDLAGRDRVVVARRP 282
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 11-276 9.27e-84

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 252.66  E-value: 9.27e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859    11 SQLPDSPSARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLDLEVAPHTLIP 90
Cdd:TIGR00536  15 SRAIARENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKGVPVAYLLGSKEFYGLEFFVNEHVLIP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859    91 RPDTELLVETALATLA--ADTATVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLE-NVEVRRSHW 167
Cdd:TIGR00536  95 RPETEELVEKALASLIsqPPILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQLEhRVEFIQSNL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   168 FSALDGRRFRMIVGNPPYIPASDPHLSEGDVRFEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHGYDQGAAVRE 247
Cdd:TIGR00536 175 FEPLAGQKIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYLKPNGFLVCEIGNWQQKSLKE 254

                         250       260       270
                  ....*....|....*....|....*....|
gi 15599859   248 LLGARG-FAGVHTLRDLGGNERITLGQWAC 276
Cdd:TIGR00536 255 LLRIKFtWYDVENGRDLNGKERVVLGFYHS 284
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 11-274 6.89e-54

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 180.28  E-value: 6.89e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   11 SQLPDSpsarlDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLDLEVAPHTLIP 90
Cdd:PRK14966 160 SKLPKN-----EARMLLQYASEYTRVQLLTRGGEEMPDEVRQRADRLAQRRLNGEPVAYILGVREFYGRRFAVNPNVLIP 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   91 RPDTELLVETALATLAADTAtVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLlENVEVRRSHWFSA 170
Cdd:PRK14966 235 RPETEHLVEAVLARLPENGR-VWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAADLG-ARVEFAHGSWFDT 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  171 --LDGRRFRMIVGNPPYIPASDPHLSEGDVRFEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHGYDQGAAVREL 248
Cdd:PRK14966 313 dmPSEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEHGFDQGAAVRGV 392

                        250       260
                 ....*....|....*....|....*.
gi 15599859  249 LGARGFAGVHTLRDLGGNERITLGQW 274
Cdd:PRK14966 393 LAENGFSGVETLPDLAGLDRVTLGKY 418
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 18-271 1.43e-35

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 133.07  E-value: 1.43e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   18 SARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLDLEVAPHTLIPRPDTELL 97
Cdd:PRK01544  23 SPQLEARILLQHVINKPIEYLLINLDEQLNEAEIEAFEKLLERRLKHEPIAYITGVKEFYSREFIVNKHVLIPRSDTEVL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   98 VETALATLAADTAT-------------------------VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNR 152
Cdd:PRK01544 103 VDVVFQCHSRESGNpekkqlnpcfrgndissncndkflnILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSNA 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  153 QRL-LLENVEVRRSHWFSALDGRRFRMIVGNPPYIPASD-PHLSEGDVRFEPKSALVAGSDGLDDIRQIVAQAPRHLLDE 230
Cdd:PRK01544 183 IKYeVTDRIQIIHSNWFENIEKQKFDFIVSNPPYISHSEkSEMAIETINYEPSIALFAEEDGLQAYFIIAENAKQFLKPN 262

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 15599859  231 GWLLLEHGYDQGAAVRELLGARGFAGVHTLRDLGGNERITL 271
Cdd:PRK01544 263 GKIILEIGFKQEEAVTQIFLDHGYNIESVYKDLQGHSRVIL 303
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 44-238 2.16e-35

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 128.01  E-value: 2.16e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859    44 RIVPREAnERFDDWIARRRNGE-PVAYILGHQGFWSLDLEVAPHTLIPR-PDTELLVET-ALATLAADTATVLDLGTGTG 120
Cdd:TIGR03533  55 RLTPSEK-ERILELIERRIEERiPVAYLTNEAWFAGLEFYVDERVLIPRsPIAELIEDGfAPWLEPEPVKRILDLCTGSG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   121 AIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLEN-VEVRRSHWFSALDGRRFRMIVGNPPYIPASD----PHlse 195
Cdd:TIGR03533 134 CIAIACAYAFPEAEVDAVDISPDALAVAEINIERHGLEDrVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDmadlPA--- 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 15599859   196 gDVRFEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHG 238
Cdd:TIGR03533 211 -EYHHEPELALASGEDGLDLVRRILAEAADHLNENGVLVVEVG 252
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 112-235 1.02e-19

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 84.09  E-value: 1.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALDGRRFRMIVGNPPYipasdp 191
Cdd:COG2813  53 VLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSNPPF------ 126

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15599859 192 HlsegdvrfepksalvAGSDGLDDI-RQIVAQAPRHLLDEGWLLL 235
Cdd:COG2813 127 H---------------AGRAVDKEVaHALIADAARHLRPGGELWL 156
PRK14967 PRK14967
putative methyltransferase; Provisional
 81-237 2.62e-19

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 83.95  E-value: 2.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   81 LEVAPHTLIPRPDTELLVETALATLAADTATVLDLGTGTGAIALALASERPLWtVTAVDRVEEAVALAERNrQRLLLENV 160
Cdd:PRK14967   9 LLRAPGVYRPQEDTQLLADALAAEGLGPGRRVLDLCTGSGALAVAAAAAGAGS-VTAVDISRRAVRSARLN-ALLAGVDV 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599859  161 EVRRSHWFSALDGRRFRMIVGNPPYIPASDPHLSegdvRFEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEH 237
Cdd:PRK14967  87 DVRRGDWARAVEFRPFDVVVSNPPYVPAPPDAPP----SRGPARAWDAGPDGRAVLDRLCDAAPALLAPGGSLLLVQ 159
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 112-263 5.89e-18

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 80.57  E-value: 5.89e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLEN-VEVRRS---HWFSALDGRRFRMIVGNPPYIP 187
Cdd:COG4123  41 VLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGdlkEFAAELPPGSFDLVVSNPPYFK 120

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15599859 188 ASDPHLSEGDVRfepKSALVAGSDGLDDIRQIVAqapRHLLDEGWLLLEHGYDQGAAVRELLGARGFaGVHTLRDL 263
Cdd:COG4123 121 AGSGRKSPDEAR---AIARHEDALTLEDLIRAAA---RLLKPGGRFALIHPAERLAEILAALRKYGL-GPKRLRPV 189
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 112-235 1.93e-17

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 77.63  E-value: 1.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALDGRRFRMIVGNPPYipasdp 191
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVEDGKFDLIISNPPF------ 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 15599859   192 HlsegdvrfepksalvAGSDGLDDI-RQIVAQAPRHLLDEGWLLL 235
Cdd:pfam05175 109 H---------------AGLATTYNVaQRFIADAKRHLRPGGELWI 138
PRK14968 PRK14968
putative methyltransferase; Provisional
 85-255 1.12e-16

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 76.09  E-value: 1.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   85 PHTLIPRPDTELLVETALATLAADtatVLDLGTGTGAIALALAsERPLWtVTAVDRVEEAVALAERNRQRLLLEN--VEV 162
Cdd:PRK14968   3 DEVYEPAEDSFLLAENAVDKKGDR---VLEVGTGSGIVAIVAA-KNGKK-VVGVDINPYAVECAKCNAKLNNIRNngVEV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  163 RRSHWFSALDGRRFRMIVGNPPYIPASDPHLSEGDVRFepksALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEH----G 238
Cdd:PRK14968  78 IRSDLFEPFRGDKFDVILFNPPYLPTEEEEEWDDWLNY----ALSGGKDGREVIDRFLDEVGRYLKPGGRILLLQssltG 153

                        170
                 ....*....|....*..
gi 15599859  239 YDqgaAVRELLGARGFA 255
Cdd:PRK14968 154 ED---EVLEYLEKLGFE 167
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 16-72 1.22e-16

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 72.51  E-value: 1.22e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15599859    16 SPSARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILG 72
Cdd:pfam17827  15 IESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 112-236 8.61e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.83  E-value: 8.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTGAIALALAsERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALD--GRRFRMIVGNPPYIPas 189
Cdd:cd02440   2 VLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeaDESFDVIISDPPLHH-- 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15599859 190 dphlsegdvrfepksalvagsdGLDDIRQIVAQAPRHLLDEGWLLLE 236
Cdd:cd02440  79 ----------------------LVEDLARFLEEARRLLKPGGVLVLT 103
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 112-169 2.25e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 54.73  E-value: 2.25e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15599859   112 VLDLGTGTGAIALALASE-RPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFS 169
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEElGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEE 65
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
112-162 2.61e-09

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 55.39  E-value: 2.61e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15599859  112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEV 162
Cdd:PRK08287  35 LIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGNIDI 85
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 112-254 2.31e-08

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 52.55  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859   112 VLDLGTGTGAIALALASERPlwTVTAVDRVEEAVALAERNrQRLLLENVEVRRSHWFSALDGRrFRMIVGNPPYIPASDp 191
Cdd:TIGR00537  23 VLEIGAGTGLVAIRLKGKGK--CILTTDINPFAVKELREN-AKLNNVGLDVVMTDLFKGVRGK-FDVILFNPPYLPLED- 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599859   192 HLSEGDVRfepKSALVAGSDGLDDIRQIVAQAPRHLLDEGWL-LLEHGYDQGAAVRELLGARGF 254
Cdd:TIGR00537  98 DLRRGDWL---DVAIDGGKDGRKVIDRFLDELPEILKEGGRVqLIQSSLNGEPDTFDKLDERGF 158
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 112-173 3.54e-08

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 50.79  E-value: 3.54e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599859   112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALDG 173
Cdd:TIGR02469  23 LWDIGAGTGSVTIEAARLVPNGRVYAIERNPEALDLIERNLRRFGVSNIVIVEGDAPEAPEA 84
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 112-184 1.10e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 52.10  E-value: 1.10e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599859 112 VLDLGTGTGAIALALAseRPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALD----GRRFRMIVGNPP 184
Cdd:COG2265 237 VLDLYCGVGTFALPLA--RRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPellwGGRPDVVVLDPP 311
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 112-164 1.62e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 48.33  E-value: 1.62e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 15599859   112 VLDLGTGTGAIALALAsERPLWTVTAVDRVEEAVALAERNRQRLLLeNVEVRR 164
Cdd:pfam13649   1 VLDLGCGTGRLTLALA-RRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQ 51
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
112-208 3.82e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 49.52  E-value: 3.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTG--AIALALASERplwTVTAVDRVEEAVALAERNRQRlLLENVEVRRSHWFSALDGRRFRMIVGNPPYiPAS 189
Cdd:COG2263  49 VLDLGCGTGmlAIGAALLGAK---KVVGVDIDPEALEIARENAER-LGVRVDFIRADVTRIPLGGSVDTVVMNPPF-GAQ 123

                        90
                ....*....|....*....
gi 15599859 190 DPHLsegDVRFEPKSALVA 208
Cdd:COG2263 124 RRHA---DRPFLEKALEIA 139
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
112-182 4.88e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 47.13  E-value: 4.88e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599859 112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAernRQRllLENVEVRRSHWFSALDGRRFRMIVGN 182
Cdd:COG4106   5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARA---RAR--LPNVRFVVADLRDLDPPEPFDLVVSN 70
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
114-162 1.39e-06

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 47.68  E-value: 1.39e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 15599859  114 DLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEV 162
Cdd:PRK07402  46 DIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKNVEV 94
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 112-180 1.51e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 46.85  E-value: 1.51e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTGAIALALASERPlWTVTAVDRVEEAVALA-ERNRQRLLLENVEVRRSHWFSALDGRRFRMIV 180
Cdd:COG2230  55 VLDIGCGWGGLALYLARRYG-VRVTGVTLSPEQLEYArERAAEAGLADRVEVRLADYRDLPADGQFDAIV 123
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
112-227 2.94e-06

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 47.63  E-value: 2.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859  112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNrqrlLLENV---EVRRSHWFSALDGrRFRMIVGNPPYipa 188
Cdd:PRK09489 200 VLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRAT----LAANGlegEVFASNVFSDIKG-RFDMIISNPPF--- 271

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 15599859  189 sdpHlsegdvrfepksalvagsDGLDD----IRQIVAQAPRHL 227
Cdd:PRK09489 272 ---H------------------DGIQTsldaAQTLIRGAVRHL 293
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 112-163 3.92e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.45  E-value: 3.92e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 15599859 112 VLDLGTGTGAIALALAsERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVR 163
Cdd:COG0500  30 VLDLGCGTGRNLLALA-ARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFL 80
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 112-162 5.74e-06

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 47.08  E-value: 5.74e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15599859 112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEV 162
Cdd:COG2242 251 LWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVPNVEV 301
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 112-180 2.74e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 42.70  E-value: 2.74e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTGAIALALASERplWTVTAVDRVEEAVALAernRQRLLLENVEVRRSHWFS-ALDGRRFRMIV 180
Cdd:COG2227  28 VLDVGCGTGRLALALARRG--ADVTGVDISPEALEIA---RERAAELNVDFVQGDLEDlPLEDGSFDLVI 92
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 112-164 6.07e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 6.07e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15599859 112 VLDLGTGTGAIALALASERplWTVTAVDRVEEAVALAERNRQRLLLeNVEVRR 164
Cdd:COG2226  26 VLDLGCGTGRLALALAERG--ARVTGVDISPEMLELARERAAEAGL-NVEFVV 75
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
112-254 7.35e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 42.29  E-value: 7.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTGAIALALASERplWTVTAVDRVEEAVALAERNRQRLLLENVEVRRshwFSALDGrRFRMIVgnppyipASDp 191
Cdd:COG4976  50 VLDLGCGTGLLGEALRPRG--YRLTGVDLSEEMLAKAREKGVYDRLLVADLAD---LAEPDG-RFDLIV-------AAD- 115

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599859 192 hlsegdvrfepksALVAgsdgLDDIRQIVAQAPRHLLDEGWLLL-------EHGYDQGAA-VRELLGARGF 254
Cdd:COG4976 116 -------------VLTY----LGDLAAVFAGVARALKPGGLFIFsvedadgSGRYAHSLDyVRDLLAAAGF 169
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 112-163 1.24e-04

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 42.00  E-value: 1.24e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15599859 112 VLDLGTGTG---AIALALASErplwtVTAVDRVEEAVALAERNRQRLLLENVEVR 163
Cdd:COG2518  70 VLEIGTGSGyqaAVLARLAGR-----VYSVERDPELAERARERLAALGYDNVTVR 119
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 112-237 1.66e-04

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 41.61  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTGAIAL-AL---ASErplwtVTAVDRVEEAVALAERNRQRL-LLENVEVRRS---HWFSALDGRRFRMIVGNP 183
Cdd:COG0742  45 VLDLFAGSGALGLeALsrgAAS-----VVFVEKDRKAAAVIRKNLEKLgLEDRARVIRGdalRFLKRLAGEPFDLVFLDP 119

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15599859 184 PYipasdphlsegdvrfepksalvaGSDGLDDIRQIVAQAPrHLLDEGWLLLEH 237
Cdd:COG0742 120 PY-----------------------AKGLLEKALELLAENG-LLAPGGLIVVEH 149
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
112-187 2.25e-04

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 41.20  E-value: 2.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599859   112 VLDLGTGTGAIALALASE-RPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRShwfsalDGRRfrmivGNPPYIP 187
Cdd:pfam01135  77 VLEIGSGSGYLTACFARMvGEVGRVVSIEHIPELVEIARRNLEKLGLENVIVVVG------DGRQ-----GWPEFAP 142
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 113-161 5.80e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.03  E-value: 5.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 15599859   113 LDLGTGTGAIALALASERPlwTVTAVDRVEEAVALAERNRQRLLLENVE 161
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA--RVTGVDISPEMLELAREKAPREGLTFVV 47
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 112-150 9.06e-04

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 39.94  E-value: 9.06e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTGAIALALASERP-LWTVTAVDRVEEAVALAER 150
Cdd:COG5459  84 VLDVGAGPGTAAWAAADAWPsLLDATLLERSAAALALGRR 123
PRK15001 PRK15001
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
112-185 1.52e-03

23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;


Pssm-ID: 184963 [Multi-domain]  Cd Length: 378  Bit Score: 39.63  E-value: 1.52e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599859  112 VLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLL---LENVEVRRSHWFSALDGRRFRMIVGNPPY 185
Cdd:PRK15001 232 IVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNMpeaLDRCEFMINNALSGVEPFRFNAVLCNPPF 308
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 112-225 1.79e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 38.24  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTG--AIALALASeRPLWTVTAVDRVEEAVALAERNRQRLLLEN-VEVRR---SHWFSALDGRRFRMIV----- 180
Cdd:COG4122  20 ILEIGTGTGysTLWLARAL-PDDGRLTTIEIDPERAAIARENFARAGLADrIRLILgdaLEVLPRLADGPFDLVFidadk 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15599859 181 -GNPPYIPASDPHLSEG------DVRFEPKSALVAGSD----GLDDIRQIVAQAPR 225
Cdd:COG4122  99 sNYPDYLELALPLLRPGglivadNVLWHGRVADPARRDpstrAIREFNEYLREDPR 154
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
112-163 2.00e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 38.65  E-value: 2.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15599859  112 VLDLGTGTG---AIaLALASERplwtVTAVDRVEEAVALAERNRQRLLLENVEVR 163
Cdd:PRK00312  82 VLEIGTGSGyqaAV-LAHLVRR----VFSVERIKTLQWEAKRRLKQLGLHNVSVR 131
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
112-276 3.41e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 38.23  E-value: 3.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 112 VLDLGTGTG--AIALAL--ASErplwtVTAVD----RVEEAVALAERNRqrlLLENVEVRRShwfSALDGRRFRMIVGNp 183
Cdd:COG2264 152 VLDVGCGSGilAIAAAKlgAKR-----VLAVDidpvAVEAARENAELNG---VEDRIEVVLG---DLLEDGPYDLVVAN- 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599859 184 pyIPAsDPhlsegdvrfepksalvagsdglddIRQIVAQAPRHLLDEGWL----LLEHgydQGAAVRELLGARGFAGVht 259
Cdd:COG2264 220 --ILA-NP------------------------LIELAPDLAALLKPGGYLilsgILEE---QADEVLAAYEAAGFELV-- 267

                       170
                ....*....|....*..
gi 15599859 260 lrdlggnERITLGQWAC 276
Cdd:COG2264 268 -------ERRERGEWVA 277
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 113-163 4.21e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 35.81  E-value: 4.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15599859   113 LDLGTGTGAIALALASERPLWTVTAVDRVEEAVALA-ERNRQRLLLENVEVR 163
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAArERLAALGLLNAVRVE 52
arsM PRK11873
arsenite methyltransferase;
112-163 6.84e-03

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 37.24  E-value: 6.84e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15599859  112 VLDLGTGTGAIALaLASER--PLWTVTAVDRVEEAVALAERNRQRLLLENVEVR 163
Cdd:PRK11873  81 VLDLGSGGGFDCF-LAARRvgPTGKVIGVDMTPEMLAKARANARKAGYTNVEFR 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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