|
Name |
Accession |
Description |
Interval |
E-value |
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
619-979 |
8.51e-88 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 287.63 E-value: 8.51e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 619 RLTGLAAELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEPWKgLLERFIDAPDEH 698
Cdd:COG5000 77 QLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELD-LAELLREALERG 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 699 LHKQRLVYDGHTRWLNLHKAAIEeplapgNSGLVLLVEDLTEtqlledkLVHSERLASIGRLAAGVAHEIGNPITGIACL 778
Cdd:COG5000 156 WQEEIELTRDGRRTLLVRASPLR------DDGYVIVFDDITE-------LLRAERLAAWGELARRIAHEIKNPLTPIQLS 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 779 AQNLREE-----REGDGELTEISEQILDQTKRVSRIVQSLMSFAHSGShlQALEPVCLSEVAQEAIGLLSLNRRSVEVEF 853
Cdd:COG5000 223 AERLRRKladklEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPE--PQLEPVDLNELLREVLALYEPALKEKDIRL 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 854 -FNLCDPAHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDpg 932
Cdd:COG5000 301 eLDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP-- 378
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15599919 933 KGTGLGLALVYSIVEEHYGQITIESptdhQREGGTRFRVTLPRHPGP 979
Cdd:COG5000 379 KGTGLGLAIVKKIVEEHGGTIELES----RPGGGTTFTIRLPLAEEA 421
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
626-982 |
3.05e-83 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 273.26 E-value: 3.05e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 626 ELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEPWKGLLERFIDAPDEH--LHKQR 703
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRELLERALAEGqpVTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 704 LVY---DGHTRWLNLHKAAIEEPlaPGNSGLVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEIGNPITGIACLAQ 780
Cdd:COG3852 81 VTLrrkDGEERPVDVSVSPLRDA--EGEGGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 781 NLREEREgDGELTEISEQILDQTKRVSRIVQSLMSFAHSGSHlqALEPVCLSEVAQEAIGLLSLN-RRSVEVEfFNLCDP 859
Cdd:COG3852 159 LLERELP-DDELREYTQLIIEEADRLNNLVDRLLSFSRPRPP--EREPVNLHEVLERVLELLRAEaPKNIRIV-RDYDPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 860 AHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHT----------VDLVVEDEGSGIPKAIMDQLFEPFFTTK 929
Cdd:COG3852 235 LPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprlyVRIEVIDNGPGIPEEILDRIFEPFFTTK 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15599919 930 DpgKGTGLGLALVYSIVEEHYGQITIESptdhQREGGTRFRVTLPRHPGPTAE 982
Cdd:COG3852 315 E--KGTGLGLAIVQKIVEQHGGTIEVES----EPGKGTTFRIYLPLEQAEEEP 361
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
610-976 |
1.40e-81 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 268.98 E-value: 1.40e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 610 ESRLEDYHSRLTGLAAELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEPWKGLLE 689
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 690 RFIDAPDEHLHKQRLVYDGHTRWlnlhkaAIEEPLAPGNSGLVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEIG 769
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDA------EENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEIN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 770 NPITGIACLAQNLRE--EREGDGE-LTEISEQILDQTKRVSRIVQSLMSFAHSGShlQALEPVCLSEVAQEAIGLLS--L 844
Cdd:COG4191 155 NPLAAILGNAELLRRrlEDEPDPEeLREALERILEGAERAAEIVRSLRAFSRRDE--EEREPVDLNELIDEALELLRprL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 845 NRRSVEVEFfNLCDPAHWVEGDSQRLAQVLINLLSNARDASP--PGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLF 922
Cdd:COG4191 233 KARGIEVEL-DLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEegEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIF 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15599919 923 EPFFTTKDPGKGTGLGLALVYSIVEEHYGQITIESptdhQREGGTRFRVTLPRH 976
Cdd:COG4191 312 EPFFTTKPVGKGTGLGLSISYGIVEKHGGRIEVES----EPGGGTTFTITLPLA 361
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
625-982 |
1.96e-59 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 211.76 E-value: 1.96e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 625 AELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEPW-KGLLERFI-----DAPDEH 698
Cdd:COG5809 134 EALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDdQENVAAFIsqllkDGGIAQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 699 LHKQRLVYDGHTRWLNLHKAAIEEPLapGNSGLVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEIGNPITGIACL 778
Cdd:COG5809 214 GEVRFWTKDGRWRLLEASGAPIKKNG--EVDGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGF 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 779 AQNLREEREGDGEL-TEIseqILDQTKRVSRIVQSLMSFAHSgshlQAL--EPVCLSEVAQEAIGLLS----LNRRSVEV 851
Cdd:COG5809 292 IQLLKDTIDEEQKTyLDI---MLSELDRIESIISEFLVLAKP----QAIkyEPKDLNTLIEEVIPLLQpqalLKNVQIEL 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 852 EFFNLCDPahwVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHT-VDLVVEDEGSGIPKAIMDQLFEPFFTTKD 930
Cdd:COG5809 365 ELEDDIPD---ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDkVVISVTDEGCGIPEERLKKLGEPFYTTKE 441
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15599919 931 pgKGTGLGLALVYSIVEEHYGQITIESptdhqREG-GTRFRVTLPRHPGPTAE 982
Cdd:COG5809 442 --KGTGLGLMVSYKIIEEHGGKITVES-----EVGkGTTFSITLPIKLSEQVS 487
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
636-975 |
1.98e-56 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 199.24 E-value: 1.98e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 636 QTLQDLPMGVCSLAKDQEVLMWNRAIEELTG------VGAQKVVGSRLSALPEPWKgllerfidapDEHLHKQRLVYDGH 709
Cdd:COG5807 31 QLFDSILEFVFFIDSKGEILECNDFAEDLYGlsqneyIGKTFVEEKCILKDEQLYN----------KEAFDRIEISYLTK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 710 TRWLNLHKAAIEEPlAPGNSGLVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEIGNPITGIACLAQNLREEREGD 789
Cdd:COG5807 101 NGEFDEIIYPIYYK-DGVILGLITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDS 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 790 gELTEISEQILDQTKRVSRIVQSLMSFAHSGShlQALEPVCLSEVAQEAIGLLSLNRRSVEVEF-FNLCDPAHWVEGDSQ 868
Cdd:COG5807 180 -EREEYFNIIISEIDRINTIITELLVLSKPKK--FNFKKLNLNDVLEDVIALLSTEAILKNISIkYDLADDEPVINGDKN 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 869 RLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDpgKGTGLGLALVYSIVEE 948
Cdd:COG5807 257 QLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKE--EGTGLGLSICKKIIEE 334
|
330 340
....*....|....*....|....*..
gi 15599919 949 HYGQITIESptdhQREGGTRFRVTLPR 975
Cdd:COG5807 335 HNGTIEVES----KPGKGTTFTIYLPL 357
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
631-974 |
3.86e-56 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 202.65 E-value: 3.86e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 631 RRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSA-LPEPWKGLLERFIDAPDE-----HLHKQRL 704
Cdd:COG5805 156 EERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLElLHPCDKEEFKERIESITEvwqefIIEREII 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 705 VYDGHTRWLNlhkaAIEEPLAPGNS---GLVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEIGNPITGIACLAQN 781
Cdd:COG5805 236 TKDGRIRYFE----AVIVPLIDTDGsvkGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQL 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 782 LREEREGDGELTEIseqILDQTKRVSRIVQSLMSFAHSGSHLqaLEPVCLSEVAQEAIGLLS--LNRRSVEVEFFNLcDP 859
Cdd:COG5805 312 LQPGIEDKEEYFDI---MLSELDRIESIISEFLALAKPQAVN--KEKENINELIQDVVTLLEteAILHNIQIRLELL-DE 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 860 AHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDpgKGTGLGL 939
Cdd:COG5805 386 DPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKE--KGTGLGL 463
|
330 340 350
....*....|....*....|....*....|....*
gi 15599919 940 ALVYSIVEEHYGQITIESPTDHqregGTRFRVTLP 974
Cdd:COG5805 464 MVSYKIIENHNGTIDIDSKVGK----GTTFTITLP 494
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
648-976 |
5.23e-56 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 197.05 E-value: 5.23e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 648 LAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEPWKGLLERFIDAPDEHLHKQRLVYDGHTRWLNLHKAAIEEPLAPG 727
Cdd:COG0642 3 LLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 728 NSGLVLLVEDLTETQLLEDKLVHSERlaSIGRLAAGVAHEIGNPITGIACLAQNLReeREGDGELTEISEQILDQTKRVS 807
Cdd:COG0642 83 LLLLLLLLLLLLLLLALLLLLEEANE--AKSRFLANVSHELRTPLTAIRGYLELLL--EELDEEQREYLETILRSADRLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 808 RIVQSLMSFAH--SGSHLQALEPVCLSEVAQEAIGLLSLNRRSVEVEF-FNLCDPAHWVEGDSQRLAQVLINLLSNARDA 884
Cdd:COG0642 159 RLINDLLDLSRleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELeLDLPDDLPTVRGDPDRLRQVLLNLLSNAIKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 885 SPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDP--GKGTGLGLALVYSIVEEHYGQITIESptdhQ 962
Cdd:COG0642 239 TPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSrrGGGTGLGLAIVKRIVELHGGTIEVES----E 314
|
330
....*....|....
gi 15599919 963 REGGTRFRVTLPRH 976
Cdd:COG0642 315 PGKGTTFTVTLPLA 328
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
622-978 |
3.63e-54 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 199.42 E-value: 3.63e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 622 GLAAELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSAL---PEPWKGLLERFIDAPDEH 698
Cdd:PRK11360 252 NLAQALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELfppNTPFASPLLDTLEHGTEH 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 699 L---------HKQRLVYDGHTRWLNLHKAAIeeplapgnsGLVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEIG 769
Cdd:PRK11360 332 VdleisfpgrDRTIELSVSTSLLHNTHGEMI---------GALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIR 402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 770 NPITGIACLAQNLREEREgDGELTEISEQILDQTKRVSRIVQSLMSFAHSGSHlqALEPVCLSEVAQEAIGLLSLNRRSV 849
Cdd:PRK11360 403 NPLTAIRGYVQIWRQQTS-DPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRES--QWQPVSLNALVEEVLQLFQTAGVQA 479
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 850 EVEFFNLCD---PAHWVegDSQRLAQVLINLLSNARDASPPGGAIRVRSE-ASEHTVDLVVEDEGSGIPKAIMDQLFEPF 925
Cdd:PRK11360 480 RVDFETELDnelPPIWA--DPELLKQVLLNILINAVQAISARGKIRIRTWqYSDGQVAVSIEDNGCGIDPELLKKIFDPF 557
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15599919 926 FTTKDpgKGTGLGLALVYSIVEEHYGQITIESptdhQREGGTRFRVTLPRHPG 978
Cdd:PRK11360 558 FTTKA--KGTGLGLALSQRIINAHGGDIEVES----EPGVGTTFTLYLPINPQ 604
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
11-491 |
4.89e-54 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 195.47 E-value: 4.89e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 11 ILISVTYLSTLFGIAWITERG-------YVPRRLVRHPLVYTLSLGVYASAWAFYGTVGLAYQYGygfLAIYLGISGAFL 83
Cdd:cd10322 3 LIIVVVYLALLLGIGLYASKKvkssedfFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYG---LSAIWYILGAAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 84 LAPVLLYPILRVTRAYQLSSLADLFAFRFRSTWAGALTTLFMLIGVLPMLALQIQAVTDSISILTRDPAQErVAFVFCTL 163
Cdd:cd10322 80 GALLLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTV-AVIIAAVI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 164 ITLFAILFGARhiatrerheGLVFAIAFESLVKLVMLGSIGLYALYGVFGGpeGLEVWLLQNQTALTTLHTPLAEGP--W 241
Cdd:cd10322 159 VILYTVFGGMR---------AVAWTDVIQGIVMLIGVLVAAIFILSKVGGG--GFSALAAALPALLLALGPGGGLGWstI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 242 RTLLLVFFAAAIVMPHMFHMIFTENlNPRALISASWGLPLFLLLMSLAVPPI-LWAGLRLGASTTPEYYTIGLGLAVDSP 320
Cdd:cd10322 228 LSLILLTGLGVLALPQVFQRILAAK-DEKTARRAFLLAGLLLLLIGFLVALIgLAARALFPDLENPDLALPTLINSLLPP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 321 ALALAAFIGGISAASGLTIVMTLALSGMVLNHLVLPLYQPPAQGniyRWLKWTRRLLIVAIIMASYAFYLLLGAEqdLSN 400
Cdd:cd10322 307 GLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASD---KKLLRVSRIAVVVVGVLALLLALLPPSI--LLL 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 401 LGIVSFVATLQFLPGALSVLYWPTANRRGFISGLIAGMLVWAITMLLPLMGnvqglylplfdviyvlddSNWHLAALSSL 480
Cdd:cd10322 382 LSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLAS------------------PLGIDPIIPAL 443
|
490
....*....|.
gi 15599919 481 AANVLVFTLVS 491
Cdd:cd10322 444 LVSLIVFVVVS 454
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
740-977 |
1.37e-53 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 187.04 E-value: 1.37e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 740 ETQLLEDKLVHSERLASigRLAAGVAHEIGNPITGIACLAQNLREEREGDGE-LTEISEQILDQTKRVSRIVQSLMSFAH 818
Cdd:COG2205 1 ELEEALEELEELERLKS--EFLANVSHELRTPLTSILGAAELLLDEEDLSPEeRRELLEIIRESAERLLRLIEDLLDLSR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 819 --SGSHLQALEPVCLSEVAQEAIGLLSLNRRSVEVEF-FNLCDPAHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRS 895
Cdd:COG2205 79 leSGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLeLDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 896 EASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGK--GTGLGLALVYSIVEEHYGQITIESptdhQREGGTRFRVTL 973
Cdd:COG2205 159 RREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGegGTGLGLAIVKRIVEAHGGTIWVES----EPGGGTTFTVTL 234
|
....
gi 15599919 974 PRHP 977
Cdd:COG2205 235 PLAE 238
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
759-977 |
5.54e-47 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 173.20 E-value: 5.54e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 759 RLAAGVAHEIGNPITGIACLAQNLREEREGDGELT-EISEQILDQTKRVSRIVQSLMSFAH--SGSHLQALEPVCLSEVA 835
Cdd:COG5002 167 EFVANVSHELRTPLTSIRGYLELLLDGAADDPEERrEYLEIILEEAERLSRLVNDLLDLSRleSGELKLEKEPVDLAELL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 836 QEAIGLLSLNRRSVEVEF-FNLCDPAHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIP 914
Cdd:COG5002 247 EEVVEELRPLAEEKGIELeLDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIP 326
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599919 915 KAIMDQLFEPFFTTkDPG-----KGTGLGLALVYSIVEEHYGQITIESptdhQREGGTRFRVTLPRHP 977
Cdd:COG5002 327 EEDLPRIFERFYRV-DKSrsretGGTGLGLAIVKHIVEAHGGRIWVES----EPGKGTTFTITLPLAR 389
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
742-974 |
3.76e-42 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 160.72 E-value: 3.76e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 742 QLLEDKLVHSERLASIGRLAAGVAHEIGNPITGIACLAQNLREEREGDGELTEISEQILDQTKRVSRIVQSLMSFAHSgS 821
Cdd:PRK10364 222 QLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKP-T 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 822 HLqALEPVCLSEVAQEAIGLLSLNRRSVEVEF-FNLCDPAHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEH 900
Cdd:PRK10364 301 HL-ALQAVDLNDLINHSLQLVSQDANSREIQLrFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA 379
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599919 901 TVDLVVEDEGSGIPKAIMDQLFEPFFTTKdpGKGTGLGLALVYSIVEEHYGQITIESptdhqREG-GTRFRVTLP 974
Cdd:PRK10364 380 GVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIVEQHGGTIQVAS-----QEGkGATFTLWLP 447
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
731-976 |
1.10e-40 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 156.45 E-value: 1.10e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 731 LVLLVEDLTETQLLEDKL--VHSERLASIGRLAAGVAHEIGNPITGIACLAQNLREEREGDGELTEISeQILDQTKRVSR 808
Cdd:COG5808 213 LLLQYNLLKRKTLLERVIqeINTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYFD-IIQEEIQRINQ 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 809 IVQSlmsFAHSGS-HLQALEPVCLSEVAQEAIGLL--SLNRRSVEVEFFNLCDPAHwVEGDSQRLAQVLINLLSNARDAS 885
Cdd:COG5808 292 IVSE---FLVLGKpTAKKLELDDLNELIEEILSIIdsEANLKNIRVEKQSLDEPLH-IKCDKDRIKQVLLNLIKNAIEAM 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 886 PPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDpgKGTGLGLALVYSIVEEHYGQITIESptdhQREG 965
Cdd:COG5808 368 KEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKE--GGTGLGLSVCKRIVEMHGGEIDIES----EEGK 441
|
250
....*....|.
gi 15599919 966 GTRFRVTLPRH 976
Cdd:COG5808 442 GTTFTIRLPLK 452
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
731-974 |
1.29e-37 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 146.17 E-value: 1.29e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 731 LVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEIGNPITGIACLAQNLREEREGDGELTEISEQILDQTKRVSRIV 810
Cdd:COG5806 175 AVYLIENLIENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAII 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 811 QSLMSFA--HSGSHlqalEPVCLSEVAQEAIGLLS--LNRRSVEVEffNLCDPAHWVEGDSQRLAQVLINLLSNARDASP 886
Cdd:COG5806 255 TDYLTFAkpQPEKL----EKIDVSEELEHVIDVLSpyANMNNVEIQ--TELEPGLYIEGDRQKLQQCLINIIKNGIEAMP 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 887 PGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKdpGKGTGLGLALVYSIVEEHYGQITIESPTDHqregG 966
Cdd:COG5806 329 NGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTK--EKGTGLGTMVSYRIIEAMNGTIRVESEVGK----G 402
|
....*...
gi 15599919 967 TRFRVTLP 974
Cdd:COG5806 403 TTFTITLP 410
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
544-978 |
5.74e-37 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 146.47 E-value: 5.74e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 544 EVEQALRDLHLPFDERRPYALRRLRDRIEANLSGLMGPSVAQDIVETFLPYKTSEESYVTEDIHFIESRLEDYHSRLTGL 623
Cdd:COG4251 57 SLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 624 AAELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEPWKGLLERFIDAPDEHLHKQR 703
Cdd:COG4251 137 LEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAE 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 704 LVYDGHTRWLNLHKAAIEEPLAPGNSGLVLLVEDLTETQLLEDKLVHSERL------------ASIGRLAAGVAHEIGNP 771
Cdd:COG4251 217 LLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEEleertaelersnEELEQFAYVASHDLREP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 772 ITGIACLAQNLREEREG--DGELTEISEQILDQTKRVSRIVQSLMSFAHSGSHLQALEPVCLSEVAQEAIGLLS--LNRR 847
Cdd:COG4251 297 LRKISGFSQLLEEDYGDklDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEprIEER 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 848 SVEVEffnlCDPAHWVEGDSQRLAQVLINLLSNA----RDASPPggAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFE 923
Cdd:COG4251 377 GAEIE----VGPLPTVRGDPTLLRQVFQNLISNAikysRPGEPP--RIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFE 450
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 15599919 924 PFFT--TKDPGKGTGLGLALVYSIVEEHYGQITIESptdhQREGGTRFRVTLPRHPG 978
Cdd:COG4251 451 IFQRlhSRDEYEGTGIGLAIVKKIVERHGGRIWVES----EPGEGATFYFTLPKAPA 503
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
739-983 |
1.85e-34 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 142.12 E-value: 1.85e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 739 TETQLLEDKLVHSERLASIGRLAAGVAHEIGN---PITGIACLAQNlREERegDGELTEISEQILDQTKRVSRIVQSLMS 815
Cdd:PRK13837 432 TERDALERRLEHARRLEAVGTLASGIAHNFNNilgAILGYAEMALN-KLAR--HSRAARYIDEIISAGARARLIIDQILA 508
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 816 FAHSGShlQALEPVCLSEVAQEAIGLL--SLNRRsVEVEFFNLCDPAHwVEGDSQRLAQVLINLLSNARDASPPGGAIRV 893
Cdd:PRK13837 509 FGRKGE--RNTKPFDLSELVTEIAPLLrvSLPPG-VELDFDQDQEPAV-VEGNPAELQQVLMNLCSNAAQAMDGAGRVDI 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 894 RSEASEHT---------------VDLVVEDEGSGIPKAIMDQLFEPFFTTKdPGkGTGLGLALVYSIVEEHYGQITIESP 958
Cdd:PRK13837 585 SLSRAKLRapkvlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFFTTR-AG-GTGLGLATVHGIVSAHAGYIDVQST 662
|
250 260
....*....|....*....|....*
gi 15599919 959 TDHqregGTRFRVTLPRHPGPTAEL 983
Cdd:PRK13837 663 VGR----GTRFDVYLPPSSKVPVAP 683
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
865-974 |
2.31e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 126.99 E-value: 2.31e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 865 GDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKD---PGKGTGLGLAL 941
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrsrKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|...
gi 15599919 942 VYSIVEEHYGQITIESptdhQREGGTRFRVTLP 974
Cdd:smart00387 81 VKKLVELHGGEISVES----EPGGGTTFTITLP 109
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
765-977 |
2.56e-34 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 138.05 E-value: 2.56e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 765 AHEIGNPITGIACLAQNLREEREGDgELTEISEQILDQTKRVSRIVQSLMSFA--HSGSHLQALEPVCLSEVAQEAIGLL 842
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEDPPPE-DRARFTGNILTQSARLQQLIDRLLELArlEQRQELEVLEPVALAALLEELVEAR 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 843 S--LNRRSVEVEFfnLCDPAhWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQ 920
Cdd:PRK11100 343 EaqAAAKGITLRL--RPDDA-RVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPR 419
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 921 LFEPFFTTKDPG---KGTGLGLALVYSIVEEHYGQITIESPTdhqrEGGTRFRVTLPRHP 977
Cdd:PRK11100 420 IFERFYSLPRPAngrKSTGLGLAFVREVARLHGGEVTLRNRP----EGGVLATLTLPRHF 475
|
|
| T2SS_HK |
NF038348 |
histidine kinase; |
734-974 |
2.25e-31 |
|
histidine kinase;
Pssm-ID: 439642 [Multi-domain] Cd Length: 574 Bit Score: 130.45 E-value: 2.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 734 LVEDLTETQLledKLVHSERLASIGRLAAGVAHEIGNPITGIACLAQNLR------------------------------ 783
Cdd:NF038348 307 LIHELEETHV---QLLQSEKLASIGQLAAGVAHEINNPIGFVSANLNTLKgwvhslldviaaqeaatpahaaqtraplaa 383
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 784 EEREGD-----GELTEISEQILDQTKRVSRIVQSLMSFAHSGSHLQAlepvclseVAQEAIGLLS-LNRRSVEVEF---- 853
Cdd:NF038348 384 AGRDADldyvrGDIMTLIDESIDGAMRVRRIVQDLRDFSRPSGDEWS--------FADLHAGLEStLNVVHNELKYkadv 455
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 854 -FNLCDPAHwVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPG 932
Cdd:NF038348 456 vREYGDLPL-VECNAAQLNQVFMNLLVNAAQAIPGRGTITIRTTCDGDHASIAISDTGKGIPPDVMGRIFDPFFTTKPVG 534
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 15599919 933 KGTGLGLALVYSIVEEHYGQITIESPTDHqregGTRFRVTLP 974
Cdd:NF038348 535 QGTGLGLSISHGIVEHHRGRIDVASEPGR----GSTFTITLP 572
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
651-974 |
6.60e-31 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 128.64 E-value: 6.60e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 651 DQEVLMWNRAIEELTGVGAQKVVGSRLSAL--PEPWKGLLERFIDAPDEH--LHKQRLVY--DGHTRWlnlhKAAIEEPL 724
Cdd:PRK13557 52 DNPIVFANRAFLEMTGYAAEEIIGNNCRFLqgPETDRATVAEVRDAIAERreIATEILNYrkDGSSFW----NALFVSPV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 725 APGNSGLVLLVE---DLTETQLLEDKLVHSERLASIGRLAAGVAHEIGN---PITG-IACLAQNLREEREGDGELTEISE 797
Cdd:PRK13557 128 YNDAGDLVYFFGsqlDVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNllqVMSGyLDVIQAALSHPDADRGRMARSVE 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 798 QILDQTKRVSRIVQSLMSFAHSgshlQALE--PVCLSEVAQeaiGLLSLNRRSV--EVEFFNLCDPAHW-VEGDSQRLAQ 872
Cdd:PRK13557 208 NIRAAAERAATLTQQLLAFARK----QRLEgrVLNLNGLVS---GMGELAERTLgdAVTIETDLAPDLWnCRIDPTQAEV 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 873 VLINLLSNARDASPPGGAIRVRSEASE---------------HTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGKGTGL 937
Cdd:PRK13557 281 ALLNVLINARDAMPEGGRVTIRTRNVEiededlamyhglppgRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGL 360
|
330 340 350
....*....|....*....|....*....|....*..
gi 15599919 938 GLALVYSIVEEHYGQITIESPTDHqregGTRFRVTLP 974
Cdd:PRK13557 361 GLSMVYGFAKQSGGAVRIYSEVGE----GTTVRLYFP 393
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-975 |
1.17e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 116.37 E-value: 1.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGKGTGLGLALVYSIVEEH 949
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQKH 83
|
90 100
....*....|....*....|....*.
gi 15599919 950 YGQITIESptdhQREGGTRFRVTLPR 975
Cdd:cd16943 84 GGTIRVAS----VPGGGTRFTIILPI 105
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
865-977 |
1.63e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 110.54 E-value: 1.63e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 865 GDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVdLVVEDEGSGIPKAIMDQLFEPFFTTKDP-GKGTGLGLALVY 943
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELT-LTVEDNGIGIPPEDLPRIFEPFSTADKRgGGGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|....
gi 15599919 944 SIVEEHYGQITIESptdhQREGGTRFRVTLPRHP 977
Cdd:pfam02518 80 KLVELLGGTITVES----EPGGGTTVTLTLPLAQ 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
761-976 |
9.25e-27 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 115.25 E-value: 9.25e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 761 AAGVAHEIGNPITGIA-----CLAQNlREEREgdgeLTEISEQILDQTKRVSRIVQSLMSFAHSGSHLQALEPVCLsEVA 835
Cdd:PRK09835 266 SADIAHEIRTPITNLItqteiALSQS-RSQKE----LEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKML-DLA 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 836 QEAIGLLSL-----NRRSVEVEFFNLcdpAHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEG 910
Cdd:PRK09835 340 DEVGKVFDFfeawaEERGVELRFVGD---PCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPG 416
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599919 911 SGIPKAIMDQLFEPFFTTkDP-----GKGTGLGLALVYSIVEEHYGQITIESPTDhqregGTRFRVTLPRH 976
Cdd:PRK09835 417 TPIAPEHLPRLFDRFYRV-DPsrqrkGEGSGIGLAIVKSIVVAHKGTVAVTSDAR-----GTRFVISLPRL 481
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
759-974 |
1.39e-25 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 111.33 E-value: 1.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 759 RLAAGVAHEIGNPITGIacLAQN---LREEREGDgELTEISEQILDQTKRVSRIVQSLMSFAHSGSHLQALEPVCLSEVA 835
Cdd:TIGR01386 243 QFSADLAHELRTPLTNL--LGQTqvaLSQPRTGE-EYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAA 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 836 Q--EAIGLLSL--NRRSVEVEFFNLCDpahwVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGS 911
Cdd:TIGR01386 320 ElaKVAEYFEPlaEERGVRIRVEGEGL----VRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGP 395
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599919 912 GIPKAIMDQLFEPFF----TTKDPGKGTGLGLALVYSIVEEHYGQITIESPtdhqrEGGTRFRVTLP 974
Cdd:TIGR01386 396 GIPPEHLSRLFDRFYrvdpARSNSGEGTGLGLAIVRSIMEAHGGRASAESP-----DGKTRFILRFP 457
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
623-975 |
3.41e-25 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 109.17 E-value: 3.41e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 623 LAAELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVgaqKVVGSRLSALpepwkgllerFIDAPDEHLHKQ 702
Cdd:COG3290 75 LLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEV----------LAEVLETGERDE 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 703 RLVYDGHTRWLNLHKAAIEEPLApgnsGLVLLVEDLTETQLLEDKLVHSERLASIGRlaaGVAHEIGNPITGIACLAQNL 782
Cdd:COG3290 142 EILLNGRVLVVNRVPIRDDGRVV----GAVATFRDRTELERLEEELEGVKELAEALR---AQRHDFRNHLHTISGLLQLG 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 783 REEregdgeltEISEQILDQTKRVSRIVQSLMSFAHSgSHLQALepvcLSEVAQEAigllslNRRSVEVEFfnlcDPAHW 862
Cdd:COG3290 215 EYD--------EALEYIDEISEELQELIDSLLSRIGN-PVLAAL----LLGKAARA------RERGIDLTI----DIDSD 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 863 VEGDSQR---LAQVLINLLSNARDAS----PPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDpGKGT 935
Cdd:COG3290 272 LPDLPLSdtdLVTILGNLLDNAIEAVeklpEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKL-GEGR 350
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 15599919 936 GLGLALVYSIVEEHYGQITIESPtdhqREGGTRFRVTLPR 975
Cdd:COG3290 351 GLGLALVKQIVEKYGGTIEVESE----EGEGTVFTVRLPK 386
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-973 |
2.84e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 97.91 E-value: 2.84e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDA--SPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGKGTGLGLALVYSIVE 947
Cdd:cd16976 1 IQQVLMNLLQNALDAmgKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVE 80
|
90 100
....*....|....*....|....*.
gi 15599919 948 EHYGQITIESptdhQREGGTRFRVTL 973
Cdd:cd16976 81 EHGGRLSVAN----EEGAGARFTFDL 102
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
10-500 |
5.97e-24 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 106.44 E-value: 5.97e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 10 LILISVTYLSTLFGIAWITER-----------GyvpRRLvrHPLVYTLSL-GVYASAWAFYGTVGLAYQYGYGFLAIYLG 77
Cdd:COG0591 5 DLIIIILYLLLLLGIGLYASRrtksledyflaG---RSL--GWWVLALSLgATWLSAWTFLGVPGLAYAYGLSALWYALG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 78 isgAFLLAPVLLYPILRVTRAYQLSSLADLFAFRFrSTWAGALTTLFMLIGVLPMLALQIQAVTDSISILTRDPAQerVA 157
Cdd:COG0591 80 ---YALGALLLALFFAPRLRRLGALTIPEFLEKRF-GRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYW--LG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 158 FVFCTLITLFAILFGarhiatrerheGLvFAIAFESLVK-LVMLGSIGL--YALYGVFGGPEGL-EVWLLQNQTALTTLH 233
Cdd:COG0591 154 ILIGALIVLLYTVLG-----------GL-RAVAWTDVLQgILMLVGLILllIVALSALGGFGELfAALPAPGLLSLFPGL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 234 TPLAEGPWRTLLLVFFAAAIVMPHMFHMIFTENlNPRALISASWglplfLLLMSLAVPPILWAGLRLGAsttpeyYTIGL 313
Cdd:COG0591 222 GFTGWLAFLGLFLAIGLGYFGQPHIVQRFLAAK-SEKEARKAAL-----IGGLLYLLFYLLAALIGLLA------RALFP 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 314 GLAVDSPALALAAFI--------GGISAASGLTIVMT------LALSGMVLNHLVLPLYQPPAQGniyRWLKWTRRLLIV 379
Cdd:COG0591 290 DLPLADPDLALPLLIlellppglAGLLLAAILAAAMStadsqlLAASSVFTRDIYKPFIKPKASD---KQLLRVSRLAVL 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 380 AIIMAsyAFYLLLGAEQDLSNLGIVSFVATLQ-FLPGALSVLYWPTANRRGFISGLIAGMLVWAITMLLPLmgnvQGLYL 458
Cdd:COG0591 367 VVGLL--ALLLALLFPSSILDLVLLAWGGLGAaLLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGG----PLGPF 440
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 15599919 459 PLFDVIYVlddsnwhlaalsSLAANVLVFTLVSLFTEASDEE 500
Cdd:COG0591 441 GWLYPILP------------GLLVSLLVFVVVSLLTKPPSEE 470
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
870-974 |
8.91e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 97.07 E-value: 8.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDASPPGGaiRVRSEASEHTVDLV-----------------VEDEGSGIPKAIMDQLFEPFFTTKDPG 932
Cdd:cd16919 1 LELAILNLAVNARDAMPEGG--RLTIETSNQRVDADyalnyrdlipgnyvcleVSDTGSGMPAEVLRRAFEPFFTTKEVG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 15599919 933 KGTGLGLALVYSIVEEHYGQITIESPTDHqregGTRFRVTLP 974
Cdd:cd16919 79 KGTGLGLSMVYGFVKQSGGHLRIYSEPGV----GTTVRIYLP 116
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
736-961 |
3.20e-23 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 105.54 E-value: 3.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 736 EDLTETQlleDKLVHSERLASIGRLAAGVAHEIGNPITGIAC--LAQNLREEREGDGELTEISEQILDQTKRVSRIVQSL 813
Cdd:COG4192 415 KNLRQTQ---DELIQAAKMAVVGQTMTSLAHELNQPLNAMSMylFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSL 491
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 814 MSFAHSGShlQALEPVCLSEVAQEAIGLLSLNRRSVEVEFfNLCDPaHWVEGDSQRLAQVLINLLSNARDASPPGGAIRV 893
Cdd:COG4192 492 RQFSRKSD--TPLQPVDLRQVIEQAWELVESRAKPQQITL-HIPDD-LMVQGDQVLLEQVLVNLLVNALDAVATQPQISV 567
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599919 894 RSEASEHTVDLVVEDEGSGIPkaIMDQLFEPFFTTKDPgkGTGLGLALVYSIVEEHYGQITIESPTDH 961
Cdd:COG4192 568 DLLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTKEV--GLGLGLSICRSIMQQFGGDLYLASTLER 631
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
866-974 |
3.36e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 95.30 E-value: 3.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 866 DSQRLAQVLINLLSNARDA------SPPGGAIRVRSEASEHTVdLVVEDEGSGIPKAIMDQLFEPFFTTKDpgKGTGLGL 939
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAiegrpsDVGEVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEPYVTTRP--KGTGLGL 77
|
90 100 110
....*....|....*....|....*....|....*
gi 15599919 940 ALVYSIVEEHYGQITIESptdhQREGGTRFRVTLP 974
Cdd:cd16944 78 AIVKKIMEEHGGRISLSN----REAGGACIRIILP 108
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-974 |
1.67e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 93.23 E-value: 1.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNA----RDASPPGGAIRVRSEASEH-TVDLVVEDEGSGIPKAIMDQLFEPFFTTKdpGKGTGLGLALVYS 944
Cdd:cd16920 1 IQQVLINLVRNGieamSEGGCERRELTIRTSPADDrAVTISVKDTGPGIAEEVAGQLFDPFYTTK--SEGLGMGLSICRS 78
|
90 100 110
....*....|....*....|....*....|
gi 15599919 945 IVEEHYGQITIESPTdhqrEGGTRFRVTLP 974
Cdd:cd16920 79 IIEAHGGRLSVESPA----GGGATFQFTLP 104
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
658-974 |
7.16e-21 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 95.15 E-value: 7.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 658 NRAIEELTGVGAQKVVGSRLSALpepwkglLERFidAPDEHLHKQ-------------RLVYDGHTRWLNLHKAAIEEpl 724
Cdd:PRK11073 33 NPAAQQLLAQSSRKLFGTPLPEL-------LSYF--SLNIELMREslqagqgftdnevTLVIDGRSHILSLTAQRLPE-- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 725 apgnsgLVLLVE----DlTETQLLEDKLVHSERLASiGRLAAGVAHEIGNPITGIACLAQnLREEREGDGELTEISEQIL 800
Cdd:PRK11073 102 ------GMILLEmapmD-NQRRLSQEQLQHAQQVAA-RDLVRGLAHEIKNPLGGLRGAAQ-LLSKALPDPALTEYTKVII 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 801 DQTKRVSRIVQSLMSFAHSGSHLQAlepvCLSEVAQEAIGLLSLNRRSvEVEFFNLCDP-----AHwvegDSQRLAQVLI 875
Cdd:PRK11073 173 EQADRLRNLVDRLLGPQRPGTHVTE----SIHKVAERVVQLVSLELPD-NVRLIRDYDPslpelAH----DPDQIEQVLL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 876 NLLSNARDA-SPPGGAIRVRSEaSEHTVDLV-----------VEDEGSGIPKAIMDQLFEPFFTTKDpgKGTGLGLALVY 943
Cdd:PRK11073 244 NIVRNALQAlGPEGGTITLRTR-TAFQLTLHgeryrlaaridIEDNGPGIPPHLQDTLFYPMVSGRE--GGTGLGLSIAR 320
|
330 340 350
....*....|....*....|....*....|.
gi 15599919 944 SIVEEHYGQITIESPTDHqreggTRFRVTLP 974
Cdd:PRK11073 321 NLIDQHSGKIEFTSWPGH-----TEFSVYLP 346
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
870-974 |
1.01e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 88.32 E-value: 1.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDASPPGG-AIRVRSEASEHTVDLV---VEDEGSGIPKAIMDQLFEPFF-----TTKDPGkGTGLGLA 940
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGVQLrfsVEDTGIGIPEEQQARLFEPFSqadssTTRKYG-GTGLGLA 79
|
90 100 110
....*....|....*....|....*....|....*
gi 15599919 941 LVYSIVEEHYGQITIESptdhqREG-GTRFRVTLP 974
Cdd:cd16922 80 ISKKLVELMGGDISVES-----EPGqGSTFTFTLP 109
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
743-978 |
2.03e-20 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 94.63 E-value: 2.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 743 LLEDKLVH--------SERLASIGRLAAGVAHEIGNPIT--GIACLAQNLREEREGDGELTEISEQILDQTKRVSRIVQS 812
Cdd:PRK09303 129 QLSDELFVlrqenetlLEQLKFKDRVLAMLAHDLRTPLTaaSLALETLELGQIDEDTELKPALIEQLQDQARRQLEEIER 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 813 LM-----SFAHSGSHLQaLEP--VCLSEVAQEAIGLLS--LNRRSVEVEffnlCD-----PAhwVEGDSQRLAQVLINLL 878
Cdd:PRK09303 209 LItdlleVGRTRWEALR-FNPqkLDLGSLCQEVILELEkrWLAKSLEIQ----TDipsdlPS--VYADQERIRQVLLNLL 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 879 SNARDASPPGGAIRVrseASEH----TVDLVVEDEGSGIPKAIMDQLFEPFFTTK-DPGK-GTGLGLALVYSIVEEHYGQ 952
Cdd:PRK09303 282 DNAIKYTPEGGTITL---SMLHrttqKVQVSICDTGPGIPEEEQERIFEDRVRLPrDEGTeGYGIGLSVCRRIVRVHYGQ 358
|
250 260
....*....|....*....|....*.
gi 15599919 953 ITIESPTDHqregGTRFRVTLPRHPG 978
Cdd:PRK09303 359 IWVDSEPGQ----GSCFHFTLPVYRG 380
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-955 |
2.36e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 84.05 E-value: 2.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGKG---TGLGLALVYSIV 946
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGqksTGLGLAFVQEVA 84
|
....*....
gi 15599919 947 EEHYGQITI 955
Cdd:cd16945 85 QLHGGRITL 93
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-974 |
4.62e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 83.60 E-value: 4.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDASPP-GGAIRVRSEaSEHTV-----------DLVVEDEGSGIPKAIMDQLFEPFFTTKDpgKGTGL 937
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTR-TQRQVtlghprhrlalRVSVIDNGPGIPPDLQDTIFYPMVSGRE--NGTGL 77
|
90 100 110
....*....|....*....|....*....|....*..
gi 15599919 938 GLALVYSIVEEHYGQITIESptdhqREGGTRFRVTLP 974
Cdd:cd16918 78 GLAIAQNIVSQHGGVIECDS-----QPGHTVFSVSLP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
736-982 |
2.24e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 90.87 E-value: 2.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 736 EDLTETQLLEDKLVHSERLASIGRLAAGVAHEIGNPIT---GIA-CLAQNLREEREGD-GELTEISEQILDQTkrvsRIV 810
Cdd:PRK10490 643 ERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTvlfGQAeILTLDLASEGSPHaRQASEIRQQVLNTT----RLV 718
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 811 QSLMSFA--HSGSHLQALEPVCLSEVAQEAIGLL--SLNRRSVEVeffNLCDPAHWVEGDSQRLAQVLINLLSNARDASP 886
Cdd:PRK10490 719 NNLLDMAriQSGGFNLRKEWLTLEEVVGSALQMLepGLSGHPINL---SLPEPLTLIHVDGPLFERVLINLLENAVKYAG 795
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 887 PGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFT-TKDPG-KGTGLGLALVYSIVEEHYGQITIESPtdhqRE 964
Cdd:PRK10490 796 AQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARgNKESAiPGVGLGLAICRAIVEVHGGTIWAENR----PE 871
|
250
....*....|....*...
gi 15599919 965 GGTRFRVTLPRHPGPTAE 982
Cdd:PRK10490 872 GGACFRVTLPLETPPELE 889
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
866-974 |
7.91e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 79.84 E-value: 7.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 866 DSQRLAQVLINLLSNARDASPPGGAIRVRSEASE-HTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPG----KGTGLGLA 940
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSStrahGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|....*
gi 15599919 941 LVYSIVEEHYGQITI-ESPTdhqreGGTRFRVTLP 974
Cdd:cd16925 81 IVKEFVELHGGTVTVsDAPG-----GGALFQVELP 110
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
709-974 |
1.91e-17 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 86.50 E-value: 1.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 709 HTRWLNLHKAAIEEPLAP-GNSGLVLLVEDLTETQ---------LLEDKLVHSERLASIGRLAAGVAHEIGNPITGIACL 778
Cdd:TIGR02938 218 TGSVIGMESDCADSFFCAaEQPYLLLTIADISNLReeqerarlsALQALMAEEERLEAIRETLSAAIHRLQGPMNLISAA 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 779 AQNLreEREGDGELTEISEQILDQTKRVSRIVQSLMSFAHSGSHLQALEPVCLSEVAQEAIGLLS--LNRRSVEVEFfnl 856
Cdd:TIGR02938 298 ISVL--QRRGDDAGNPASAAMLQQALSAGREHMEALRQVIPQSPQEIVVPVNLNQILRDVITLSTprLLAAGIVVDW--- 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 857 cDPAH---WVEGDSQRLAQVLINLLSNARDASPPGGA----IRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTK 929
Cdd:TIGR02938 373 -QPAAtlpAILGRELQLRSLFKALVDNAIEAMNIKGWkrreLSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTK 451
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 15599919 930 DP-GKGTGLGLALVYSIVEEHYGQITIEspTDHQreGGTRFRVTLP 974
Cdd:TIGR02938 452 GGsRKHIGMGLSVAQEIVADHGGIIDLD--DDYS--EGCRIIVEFR 493
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
866-974 |
2.07e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 78.66 E-value: 2.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 866 DSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGK----GTGLGLAL 941
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAI 80
|
90 100 110
....*....|....*....|....*....|...
gi 15599919 942 VYSIVEEHYGQITIEsptdHQREGGTRFRVTLP 974
Cdd:cd16946 81 CHNIALAHGGTISAE----HSPLGGLRLVLTLP 109
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-974 |
6.41e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 76.94 E-value: 6.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDAS----PPGGAIRV--RSEASEhtVDLVVEDEGSGIPKAIMDQLFEPFFTTKdPGKGTGLGLALVY 943
Cdd:cd16915 1 LITIVGNLIDNALDALaatgAPNKQVEVflRDEGDD--LVIEVRDTGPGIAPELRDKVFERGVSTK-GQGERGIGLALVR 77
|
90 100 110
....*....|....*....|....*....|.
gi 15599919 944 SIVEEHYGQITIESptdhQREGGTRFRVTLP 974
Cdd:cd16915 78 QSVERLGGSITVES----EPGGGTTFSIRIP 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-974 |
1.28e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 76.46 E-value: 1.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDASPPG-GAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDP----GKGTGLGLALVYS 944
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPAneafGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 15599919 945 IVEEHYGQITIESPTDHQREGGTRFRVTLP 974
Cdd:cd16953 81 IIEAHGGISVAENHNQPGQVIGARFTVQLP 110
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
742-975 |
6.76e-16 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 80.40 E-value: 6.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 742 QLLEdKLVHS---ERLasigrLAAGVAHEIGNPITGIAClaqNLreeregdgELTEISEQI--------LDQTKRVsrIV 810
Cdd:PRK10755 125 QLVS-RLTSTldqERL-----FTADVAHELRTPLAGIRL---HL--------ELLEKQHHIdvapliarLDQMMHT--VE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 811 QSLM------SFAhSGSHlqalEPVCL-SEV---AQEAIGLLsLNRRSVEVEFFNLCDPAHwVEGDSQRLAQVLINLLSN 880
Cdd:PRK10755 186 QLLQlaragqSFS-SGHY----QTVKLlEDVilpSQDELSEM-LEQRQQTLLLPESAADIT-VQGDATLLRLLLRNLVEN 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 881 ARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGKGTGLGLALVYSIVEEHYGQITIEsptD 960
Cdd:PRK10755 259 AHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQ---N 335
|
250
....*....|....*
gi 15599919 961 HQREGGTRFRVTLPR 975
Cdd:PRK10755 336 RQERSGTRAWVWLPK 350
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
760-974 |
1.61e-15 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 79.95 E-value: 1.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 760 LAAGVAHEIGNPITGI-----------ACLAQNLREEREgdgELTEISEQILDQTKRVSRivqslMSFahsgshlqalEP 828
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIrlatemmseedGYLAESINKDIE---ECNAIIEQFIDYLRTGQE-----MPM----------EM 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 829 VCLSEVAQEAIglLSLNRRSVEVEFfNLCDPAHWVEGDSQRLAQVLINLLSNA-RDASppgGAIRVRSEASEHTVDLVVE 907
Cdd:PRK09467 294 ADLNALLGEVI--AAESGYEREIET-ALQPGPIEVPMNPIAIKRALANLVVNAaRYGN---GWIKVSSGTEGKRAWFQVE 367
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 908 DEGSGIPKAIMDQLFEPfFTTKDP---GKGTGLGLALVYSIVEEHYGQITIespTDHqREGGTRFRVTLP 974
Cdd:PRK09467 368 DDGPGIPPEQLKHLFQP-FTRGDSargSSGTGLGLAIVKRIVDQHNGKVEL---GNS-EEGGLSARAWLP 432
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
861-956 |
3.26e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 72.44 E-value: 3.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 861 HWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVdLVVEDEGSGIPKAIMDQLFEPFF-TTKDPGKGTGLGL 939
Cdd:cd16940 5 IQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYrSDGQNYGGSGLGL 83
|
90
....*....|....*..
gi 15599919 940 ALVYSIVEEHYGQITIE 956
Cdd:cd16940 84 SIVKRIVELHGGQIFLG 100
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-974 |
3.50e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 69.28 E-value: 3.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNA----RDASPPGGAIRVRSEASEHTvdLVVEDEGSGIPKAIMDQLFEPF--FTTKDPGKGTGLGLALVY 943
Cdd:cd16921 1 LGQVLTNLLGNAikfrRPRRPPRIEVGAEDVGEEWT--FYVRDNGIGIDPEYAEKVFGIFqrLHSREEYEGTGVGLAIVR 78
|
90 100 110
....*....|....*....|....*....|.
gi 15599919 944 SIVEEHYGQITIESptdhQREGGTRFRVTLP 974
Cdd:cd16921 79 KIIERHGGRIWLES----EPGEGTTFYFTLP 105
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
762-979 |
3.52e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 77.25 E-value: 3.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 762 AGVAHEIGNPITGIACLAQNLREEREGDGELTEIsEQILDQTKRVSRIVQSLMSFA--HSGSHLQAL--EPVCLSEVAQE 837
Cdd:PRK11466 449 AAMSHEIRTPLYGILGTAQLLADNPALNAQRDDL-RAITDSGESLLTILNDILDYSaiEAGGKNVSVsdEPFEPRPLLES 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 838 AIGLLS--LNRRSVEVEFFNLCDPAHWVEGDSQRLAQVLINLLSNARDASPPGgAIRVRSEASEHTVDLVVEDEGSGIPK 915
Cdd:PRK11466 528 TLQLMSgrVKGRPIRLATDIADDLPTALMGDPRRIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVEDSGCGIDP 606
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599919 916 AIMDQLFEPFFTTKDPGKGTGLGLALVYSIVEEHYGQITIESpTDHQregGTRFRVTLP-RHPGP 979
Cdd:PRK11466 607 AKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATS-TPEV---GSCFCLRLPlRVATA 667
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-974 |
4.87e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 69.01 E-value: 4.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDASppGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDP--GKGTGLGLALVYSIVE 947
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNArgTSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|....*..
gi 15599919 948 EHYGQITIESptdhQREGGTRFRVTLP 974
Cdd:cd16950 79 AHGGSLTLAN----RAGGGLCARIELP 101
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
751-974 |
4.90e-14 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 76.60 E-value: 4.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 751 SERLASIgrlaagvAHEIGNPITGIAC---LAQNlreeregdGELTEISEQILDQTKRVSR----IVQSLMSFAH--SGS 821
Cdd:PRK15347 399 SEHLTTI-------SHEIRTPLNGVLGaleLLQN--------TPLTAEQMDLADTARQCTLsllaIINNLLDFSRieSGQ 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 822 ---HLQALEPVCLSEVAQEAIGLLSLNRrSVEVEFFNLCDPAHWVEGDSQRLAQVLINLLSNARDASPPGGaIRVRSEAS 898
Cdd:PRK15347 464 mtlSLEETALLPLLDQAMLTIQGPAQSK-SLTLRTFVGAHVPLYLHLDSLRLRQILVNLLGNAVKFTETGG-IRLRVKRH 541
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15599919 899 EHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGKGTGLGLALVYSIVEEHYGQITIESPTDHqregGTRFRVTLP 974
Cdd:PRK15347 542 EQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGV----GSCFSLVLP 613
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
876-974 |
5.91e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 68.77 E-value: 5.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 876 NLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPG----KGTGLGLALVYSIVEEHYG 951
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERcrntGGTGLGLAIVKHVMSRHDA 86
|
90 100
....*....|....*....|...
gi 15599919 952 QITIESPTDHqregGTRFRVTLP 974
Cdd:cd16952 87 RLLIASELGK----GSRFTCLFP 105
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-974 |
8.34e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 68.18 E-value: 8.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFF---TTKDPGkGTGLGLALVYSIV 946
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdNSRNTE-GAGLGLSIAKAII 79
|
90 100
....*....|....*....|....*...
gi 15599919 947 EEHYGQITIESPTDHqreggTRFRVTLP 974
Cdd:cd16923 80 ELHGGSASAEYDDNH-----DLFKVRLP 102
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
658-974 |
1.01e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 75.36 E-value: 1.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 658 NRAIEELTGVGAQKVVGsrLSalpePW----KGLLERFIDApDEHL--HKQRLVY-------DGHTRWLNLHKAaieePL 724
Cdd:PRK11091 181 NRAMELLTGKSEKQLIG--LT----PKdvysPEAAEKVIET-DEKVfrHNVSLTYeqwldypDGRKACFELRKV----PF 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 725 --APGN-SGLVLLVEDLTETQLLEDKLVHSERlaSIGRLAAGVAHEIGNPITGIACLAQNLReeregDGELTEiseqilD 801
Cdd:PRK11091 250 ydRVGKrHGLMGFGRDITERKRYQDALEKASR--DKTTFISTISHELRTPLNGIVGLSRILL-----DTELTA------E 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 802 QTKRVSRIvqslmsfahsgsHLQAlepVCLSEVAQEAIGLLSLNRRSVE-----VEF---------------------FN 855
Cdd:PRK11091 317 QRKYLKTI------------HVSA---ITLGNIFNDIIDMDKMERRKLQldnqpIDFtdfladlenlsglqaeqkglrFD 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 856 LcDPA----HWVEGDSQRLAQVLINLLSNARDASPPGG-AIRVRSEASEhTVDLVVEDEGSGIPKAIMDQLFEPFFTTKD 930
Cdd:PRK11091 382 L-EPLlplpHKVITDGTRLRQILWNLISNAVKFTQQGGvTVRVRYEEGD-MLTFEVEDSGIGIPEDELDKIFAMYYQVKD 459
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 15599919 931 -----PGKGTGLGLALVYSIVEEHYGQITIESPTDHqregGTRFRVTLP 974
Cdd:PRK11091 460 shggkPATGTGIGLAVSKRLAQAMGGDITVTSEEGK----GSCFTLTIH 504
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
826-976 |
2.16e-13 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 73.48 E-value: 2.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 826 LEPVCLSEVAQEAIGllslNRRSVEVEFFNLCDPAH---WVEGDSQRLAQVLINLLSNARDASppGGAIRVRSEASEHTV 902
Cdd:PRK10604 277 LSEPDLPAWLSTHLA----DIQAVTPEKTVRLDTPHqgdYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQA 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 903 DLVVEDEGSGIPKAIMDQLFEPfFTTKDPGK-----GTGLGLALVYSIVEEHYGQITIE-SPTdhqreGGTRFRVTLPRH 976
Cdd:PRK10604 351 CLIVEDDGPGIPPEERERVFEP-FVRLDPSRdratgGCGLGLAIVHSIALAMGGSVNCDeSEL-----GGARFSFSWPVW 424
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-975 |
2.20e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 67.07 E-value: 2.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNA-RDASPpggAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTkDPGK-----GTGLGLALVY 943
Cdd:cd16939 1 MARALDNLLRNAlRYAHR---TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRL-DPSRdratgGFGLGLAIVH 76
|
90 100 110
....*....|....*....|....*....|...
gi 15599919 944 SIVEEHYGQITI-ESPTdhqreGGTRFRVTLPR 975
Cdd:cd16939 77 RVALWHGGHVECdDSEL-----GGACFRLTWPR 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
866-974 |
3.98e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 66.54 E-value: 3.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 866 DSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKD---PGKGTGLGLALV 942
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENgrnFQESTGMGLYLV 81
|
90 100 110
....*....|....*....|....*....|...
gi 15599919 943 YSIVEEHYGQITIESptdhqREG-GTRFRVTLP 974
Cdd:cd16948 82 KKLCDKLGHKIDVES-----EVGeGTTFTITFP 109
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
866-958 |
8.92e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.56 E-value: 8.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 866 DSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFF---TTKDPGKGTGLGLALV 942
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYrddTSRRSGGHYGMGLYIA 80
|
90
....*....|....*.
gi 15599919 943 YSIVEEHYGQITIESP 958
Cdd:cd16975 81 KNLVEKHGGSLIIENS 96
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
865-982 |
1.24e-12 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 71.20 E-value: 1.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 865 GDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKD----PGKGTGLGLA 940
Cdd:PRK10549 348 GDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGsrnrASGGSGLGLA 427
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 15599919 941 LVYSIVEEHYGQITiespTDHQREGGTRFRVTLPRHPGPTAE 982
Cdd:PRK10549 428 ICLNIVEAHNGRII----AAHSPFGGVSITVELPLERDLQRE 465
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
51-493 |
6.27e-12 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 69.07 E-value: 6.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 51 YASAWAFYGTVGLAYQYGYGFLAIYLGISGAFLLAPVLLYPILRVTRAYqlsSLADLFAFRFRSTWAGALTTLFMLIGVL 130
Cdd:cd11480 48 YMSAASFLGIAGLIALSGYDGLAYAIGWTGGYVLLLLLVAEPLRNFGKY---TVPDFLGARLGSRPVRLVAAVSTLVISF 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 131 PMLALQIQAVTDSISILTRDPAQERVAFVfCTLITLFAILFGARhiatrerheglvfAIAFESLVKLVML---GSIGLYA 207
Cdd:cd11480 125 FYLVAQMVGAGLLLSLLLGIPYEVGVVVV-GALMIVYVVLGGMR-------------ATTWVQIIQYVLLlgaFLVPAIL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 208 LYGVFGGPEGLEVW--LLQNQTALTTLHTPLAE------GPWRTLLLVF--FAAAIVMPHMFHMIFTeNLNPR-ALISAS 276
Cdd:cd11480 191 VLARFGGNPLGAGPglLGLAAAAASGAGEAYLApgllltDPLDVISLTLalMLGTAGLPHVLMRFYT-VPDARaARKSVV 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 277 WGLPLFLLLMSLAvpPILWAGLR--LGASTTPEYYTIGLGLAVDSPALALAAFIGG----------------ISAASGLT 338
Cdd:cd11480 270 WALGFIGLFYLLA--PALGFGARalVGPDVIGAPIAGELDGGGDMAVLLLPEIAGLgdlllalvaagafaaiLATVAGLL 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 339 IVMTLALSGMVLNHLVLPLYQPPAQGNIYRwlkwtrrllIVAIIMASYAFYLLLGAEQdlsnlGIVSFVATLQF------ 412
Cdd:cd11480 348 LAAASALAHDLYAGVIRPGASERREVRVAR---------IAAVVVGVIAILLALLFPP-----QNVAFLVALAFaiaasa 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 413 -LPGALSVLYWPTANRRGFISGLIAGMLVWAITMLL--PLMGNVQGLYLPLFDVIYvlddsnwhlAALSSLAANVLVFTL 489
Cdd:cd11480 414 fFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVLIVLspAVSGAPPGHDFAGFPLTN---------PGLVSVPLGFLVAIV 484
|
....
gi 15599919 490 VSLF 493
Cdd:cd11480 485 VSLL 488
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
870-974 |
1.46e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 61.96 E-value: 1.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDASPpgGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDP----GKGTGLGLALVYSI 945
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSArdreSGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*....
gi 15599919 946 VEEHYGQITIEsptDHQReGGTRFRVTLP 974
Cdd:cd16949 79 IEQHGGKIKAS---NRKP-GGLRVRIWLP 103
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
762-974 |
2.11e-11 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 67.34 E-value: 2.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 762 AGVAHEIGNPITGIACLAQnLREEREGDGELTEISEQIL-DQTKRVSRIVQSLMSFA--HSGSHLQALE----PVCLSEV 834
Cdd:PRK11006 209 ANVSHELRTPLTVLQGYLE-MMQDQPLEGALREKALHTMrEQTQRMEGLVKQLLTLSkiEAAPTIDLNEkvdvPMMLRVL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 835 AQEAIGLlSLNRRSVEvefFNLcDPAHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIP 914
Cdd:PRK11006 288 EREAQTL-SQGKHTIT---FEV-DNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIA 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599919 915 KAIMDQLFEPFF-----TTKDPGkGTGLGLALVYSIVEEHYGQITIESPTDHqregGTRFRVTLP 974
Cdd:PRK11006 363 PEHIPRLTERFYrvdkaRSRQTG-GSGLGLAIVKHALSHHDSRLEIESEVGK----GTRFSFVLP 422
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
754-817 |
5.04e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 59.15 E-value: 5.04e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599919 754 LASIGRLAAGVAHEIGNPITGIACLAQNLREEREGDGELTEISEQILDQTKRVSRIVQSLMSFA 817
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
870-974 |
1.04e-10 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 65.32 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 870 LAQVLINLLSNARDA--SPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKdpGKGTGLGLALVYSIVE 947
Cdd:PRK11086 434 LITILGNLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTK--GSNRGVGLYLVKQSVE 511
|
90 100
....*....|....*....|....*..
gi 15599919 948 EHYGQITIESptdhQREGGTRFRVTLP 974
Cdd:PRK11086 512 NLGGSIAVES----EPGVGTQFFVQIP 534
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
858-973 |
1.31e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 59.95 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 858 DPAHWVEGDSQRLAQVLINLLSNA-RDASppgGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGKGTG 936
Cdd:cd16954 26 SPELRFPGERNDLMELLGNLLDNAcKWCL---EFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRPGQG 102
|
90 100 110
....*....|....*....|....*....|....*..
gi 15599919 937 LGLALVYSIVEEHYGQITIEsptdHQREGGTRFRVTL 973
Cdd:cd16954 103 LGLAIAKEIVEQYGGELSLS----DSPLGGARFEVVF 135
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
759-973 |
1.51e-10 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 64.67 E-value: 1.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 759 RLAAGVAHEIGNPI------TGIACLAQNLREEREGdgELTEISEQIldqtKRVSRIVQSLMSFAH--SGSHLQALEPVC 830
Cdd:PRK10337 239 RFTSDAAHELRSPLaalkvqTEVAQLSDDDPQARKK--ALLQLHAGI----DRATRLVDQLLTLSRldSLDNLQDVAEIP 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 831 LSEVAQEAIGLLSLNRRSVEVEFfNLCDPAHWVEGDSQRLAQVLI--NLLSNARDASPPGGAIRVRSEASEhtvdLVVED 908
Cdd:PRK10337 313 LEDLLQSAVMDIYHTAQQAGIDV-RLTLNAHPVIRTGQPLLLSLLvrNLLDNAIRYSPQGSVVDVTLNARN----FTVRD 387
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599919 909 EGSGIPKAIMDQLFEPFFttKDPGK---GTGLGLALVYSIVEEHYGQITIesptDHQREGGtrFRVTL 973
Cdd:PRK10337 388 NGPGVTPEALARIGERFY--RPPGQeatGSGLGLSIVRRIAKLHGMNVSF----GNAPEGG--FEAKV 447
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
855-973 |
5.68e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 57.91 E-value: 5.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 855 NLCDPAHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPG-- 932
Cdd:cd16947 6 NIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRns 85
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 15599919 933 --KGTGLGLALVYSIVEEHYGQITIESpTDHQReggTRFRVTL 973
Cdd:cd16947 86 akQGNGLGLTITKRLAESMGGSIYVNS-KPYEK---TVFTVTL 124
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
863-974 |
1.53e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 61.91 E-value: 1.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 863 VEGDSQRLAQVLINLLSNARDASPPGGAI---RVRseasEHTVDLVVEDEGSGIP-KAIMdQLFEPFFT----TKDPGKG 934
Cdd:PRK10841 556 LNGDPMRLQQVISNLLSNAIKFTDTGCIVlhvRVD----GDYLSFRVRDTGVGIPaKEVV-RLFDPFFQvgtgVQRNFQG 630
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 15599919 935 TGLGLALVYSIVEEHYGQITIESptdhQREGGTRFRVTLP 974
Cdd:PRK10841 631 TGLGLAICEKLINMMDGDISVDS----EPGMGSQFTIRIP 666
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
863-979 |
4.98e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 60.25 E-value: 4.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 863 VEGDSQRLAQVLINLLSNARDASPPGG-AIRVRSEA-SEHTVDLVVE--DEGSGIPKAIMDQLFEPF-----FTTKDPGk 933
Cdd:PRK11107 402 VIGDPLRLQQIITNLVGNAIKFTESGNiDILVELRAlSNTKVQLEVQirDTGIGISERQQSQLFQAFrqadaSISRRHG- 480
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 15599919 934 GTGLGLALVYSIVEEHYGQITIESPTDHqregGTRFRVTLPRHPGP 979
Cdd:PRK11107 481 GTGLGLVITQKLVNEMGGDISFHSQPNR----GSTFWFHLPLDLNP 522
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
759-977 |
7.85e-09 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 59.18 E-value: 7.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 759 RLAAGVAHEIGNPITGIAcLAQNLREEREGDG-ELTEISEQI--LDQTkrVSRIVQslMSFAHSGSHLQaLEPVCLSEVA 835
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQ-LATALLRRRQGESkELERIETEAqrLDSM--INDLLV--LSRNQQKNHLE-RETFKANSLW 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 836 QEAigllsLNRRSVEVE-----FFNLCDPAHW-VEGDSQRLAQVLINLLSNARDASppGGAIRVRSEASEHTVDLVVEDE 909
Cdd:PRK09470 319 SEV-----LEDAKFEAEqmgksLTVSAPPGPWpINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDD 391
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599919 910 GSGIPKAIMDQLFEPFF---TTKD--PGkGTGLGLALVYSIVEEHYGQITIE-SPTdhqreGGTRFRVTLPRHP 977
Cdd:PRK09470 392 GPGVPEEEREQIFRPFYrvdEARDreSG-GTGLGLAIVENAIQQHRGWVKAEdSPL-----GGLRLTIWLPLYK 459
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
756-817 |
1.52e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 52.21 E-value: 1.52e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599919 756 SIGRLAAGVAHEIGNPITGIACLAQNLREEREGDgELTEISEQILDQTKRVSRIVQSLMSFA 817
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDE-EQREYLETILRSAERLLRLINDLLDLS 61
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
885-975 |
2.70e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 57.34 E-value: 2.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 885 SPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFfttKDPGKGTGLGLALVYSIVEEHYG---QITIESptdh 961
Cdd:COG2972 356 KEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL---SSKGEGRGIGLRNVRERLKLYYGeeyGLEIES---- 428
|
90
....*....|....
gi 15599919 962 QREGGTRFRVTLPR 975
Cdd:COG2972 429 EPGEGTTVTIRIPL 442
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
40-493 |
4.34e-08 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 56.75 E-value: 4.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 40 HPLVYTLSLG-VYASAWAFYGTVGLAYQYGYGFLAIYLGISGAFLLAPVLLYPILRV-TRAYQLSSLADLFAFRFR--ST 115
Cdd:cd11475 36 GPWVTALSAGaSDMSGWLLLGLPGAAYASGLSAIWIAIGLILGAYLNWLFVAKRLRRyTEKNDSITLPDYLENRFRdkSK 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 116 WAGALTTLFMLIGVLPMLALQIQAVTDSISILTRDPAQerVAFVFCTLITLFAILFGarhiatrerheGLVFAI---AFE 192
Cdd:cd11475 116 LLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYS--TGLLIGAVVVVAYTFLG-----------GFLAVSwtdFFQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 193 SLVKLVMLGSIGLYALYGVFGGPEGLEVWLLQNQTALTTLHTPLAEGPWRTLL--LVFFAAAIVMPHM---FHMIFTENL 267
Cdd:cd11475 183 GLLMLLALVLVPIVALAALGGLSGLVAALAAIDPGLLSPFGGDLGAGGLLAIIslLAWGLGYFGQPHIlvrFMAIRSPKE 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 268 NPRA-LISASWglPLFLLLMSLAVPPILWAGLRLGASTTPEYYTIGLGLAVDSPALA---LAAFIGGI-SAASGLTIVMT 342
Cdd:cd11475 263 IKKArRIAMVW--MILFLLGAVLVGLLGRALFPDGLLGDPETVFPVLAQELFPPWLAgilLAAILAAImSTADSQLLVCS 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 343 LALSGMVLNHLVLPLYQppaQGNIYRWLKWTrrLLIVAIImasyAFYLLLGAEQdlSNLGIVSFV-----ATlqFLPGAL 417
Cdd:cd11475 341 SALTEDLYKAFLRKEAS---DKELVWVSRLA--VLVIALI----ALLIALNPPS--SVFSLVSFAwaglgAA--FGPLLL 407
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15599919 418 SVLYWPTANRRGFISGLIAGMLVwaiTMLLPLMGNvqglylpLFDVIYVLddsnwhlaaLSSLAANVLVFTLVSLF 493
Cdd:cd11475 408 LSLYWKRTTRQGALAGMIAGAVT---VVVWKLLGL-------GIFGLYEI---------VPGFLASLLAIVVVSLL 464
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
866-975 |
4.66e-08 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 56.76 E-value: 4.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 866 DSQRLAQVLINLLSNARDAS--PPGGAIRVRSEASEHTVDLVVE--DEGSGIPKAIMDQLFEPFFTTK--DPGKgTGLGL 939
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASlrSDEGNKIVELFLSDEGDDVVIEvaDQGCGVPESLRDKIFEQGVSTRadEPGE-HGIGL 507
|
90 100 110
....*....|....*....|....*....|....*.
gi 15599919 940 ALVYSIVEEHYGQITIEsptDHQrEGGTRFRVTLPR 975
Cdd:PRK15053 508 YLIASYVTRCGGVITLE---DND-PCGTLFSIFIPK 539
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
467-974 |
1.02e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 55.68 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 467 LDDSNWHLAALSSLAANVLVFTLVSLFTEASDEEKGAAEACAVDNVRRPQRRELFAGSPQEFASQLAKPLGAKTAQKEVE 546
Cdd:COG3920 6 LLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 547 QALRDLHLPFDERRPYALRRLRDRIEANLSGLMGPSVAQDIVETFLPYKTSEESYVTEDIHFIESRLEDYHSRLTGLAAE 626
Cdd:COG3920 86 VLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 627 LDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEPWKGLLERFIDAPDEHLHKQRLVY 706
Cdd:COG3920 166 ELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRR 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 707 DGHTRWLNLHkAAIEEPLAPGNSGLVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEIGNPITGIACLAqNLREER 786
Cdd:COG3920 246 RARGLGRLLL-LLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLLRELHHRVKNNLQVVSSLL-RLQARR 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 787 EGDGELTEISEQIldqtkrVSRIvQSlMSFAHSG-SHLQALEPVCLSEVAQEAIGLL--SLNRRSVEVEffnlcdpahwV 863
Cdd:COG3920 324 ADDPEAREALEES------QNRI-QA-LALVHELlYQSEDWEGVDLRDYLRELLEPLrdSYGGRGIRIE----------L 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 864 EGDSQRL----AQVL---IN-LLSNA---RDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAImdqlfepffttkDPG 932
Cdd:COG3920 386 DGPDVELpadaAVPLgliLNeLVTNAlkhAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDV------------DPP 453
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 15599919 933 KGTGLGLALVYSIVEEHYGQITIESPTdhqregGTRFRVTLP 974
Cdd:COG3920 454 ARKGLGLRLIRALVRQLGGTLELDRPE------GTRVRITFP 489
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
756-817 |
1.27e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 49.49 E-value: 1.27e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599919 756 SIGRLAAGVAHEIGNPITGIACLAQNLREErEGDGELTEISEQILDQTKRVSRIVQSLMSFA 817
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDT-ELSEEQREYLETILREAERLLRLINDLLDLS 61
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
624-768 |
3.17e-06 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 49.64 E-value: 3.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 624 AAELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSAL--PEPWKGLLERFIDA----PDE 697
Cdd:COG2202 3 EEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLlpPEDDDEFLELLRAAlaggGVW 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599919 698 HLHKQRLVYDGHTRWLNLHKAAIeePLAPGN-SGLVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEI 768
Cdd:COG2202 83 RGELRNRRKDGSLFWVELSISPV--RDEDGEiTGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFV 152
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
625-748 |
3.50e-06 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 49.64 E-value: 3.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 625 AELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEP-----WKGLLERFIDAPDEHL 699
Cdd:COG2202 130 EALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPedrerLLELLRRLLEGGRESY 209
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 15599919 700 HKQRLVYDGHTRWLNLHKAAIEEPLAPGNSGLVLLVEDLTETQLLEDKL 748
Cdd:COG2202 210 ELELRLKDGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
859-974 |
3.98e-06 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 50.89 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 859 PAHW-VEGDSQRLAQVLINLLSNARDASPPGgAIRVRS-----EASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPG 932
Cdd:PRK09959 817 PDHYlVKIDPQAFKQVLSNLLSNALKFTTEG-AVKITTslghiDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGR 895
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 15599919 933 K--GTGLGLALVYSIVEEHYGQITIESptdhQREGGTRFRVTLP 974
Cdd:PRK09959 896 QqtGSGLGLMICKELIKNMQGDLSLES----HPGIGTTFTITIP 935
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
856-975 |
4.40e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 46.83 E-value: 4.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 856 LCDPAHWVEGDSQRLAQVLINLLSNAR---DASPPGGAIRVRSEASEHTVDLVVEDEGSGIPkaiMDQLFEPFfttkDPG 932
Cdd:COG2172 21 LLRELGLDEDDADDLVLAVSEAVTNAVrhaYGGDPDGPVEVELELDPDGLEIEVRDEGPGFD---PEDLPDPY----STL 93
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 15599919 933 KGTGLGLALVYSIVEEhygqITIESptdhqREGGTRFRVTLPR 975
Cdd:COG2172 94 AEGGRGLFLIRRLMDE----VEYES-----DPGGTTVRLVKRL 127
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
773-979 |
5.25e-06 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 50.02 E-value: 5.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 773 TGIACLAQNLREEREGDGELTEISEQI-LDQtkrVSRIVQSLMSFAHSGShLQALEPVCLSEVAQEAIGLLSL------- 844
Cdd:PRK10815 279 TPLAVLQSTLRSLRSGKQMSVEQAEPImLEQ---ISRISQQIGYYLHRAS-MRSEHNLLSRELHSVAPLLDNLtsalnkv 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 845 -NRRSVEVEFfNLCDPAHWVeGDSQRLAQVLINLLSNARDASPPGGAIRVRSeaSEHTVDLVVEDEGSGIPKAIMDQLFE 923
Cdd:PRK10815 355 yQRKGVNITL-DISPEITFV-GEKNDFMEVMGNVLDNACKYCLEFVEISARQ--TDEHLHIVVEDDGPGIPESKRELIFD 430
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 924 --PFFTTKDPGKGtgLGLALVYSIVEEHYGQITI-ESPTdhqreGGTRFRVTLPR-HPGP 979
Cdd:PRK10815 431 rgQRADTLRPGQG--LGLSVAREITEQYEGKISAgDSPL-----GGARMEVIFGRqHSTP 483
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
767-977 |
4.67e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 46.15 E-value: 4.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 767 EIGNPITGIACLAQNLREEREGDGE-----LTEISEQILDQTKRVSRIVQSLMSFAHSGSHLQALepvcLSEVAQEAigl 841
Cdd:COG4585 64 GVGQSLSAIKLQLEAARRLLDADPEaareeLEEIRELAREALAELRRLVRGLRPPALDDLGLAAA----LEELAERL--- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 842 lsLNRRSVEVEFFnlcdpahwVEGDSQRL-AQVLINL-------LSNAR---DASppggAIRVRSEASEHTVDLVVEDEG 910
Cdd:COG4585 137 --LRAAGIRVELD--------VDGDPDRLpPEVELALyrivqeaLTNALkhaGAT----RVTVTLEVDDGELTLTVRDDG 202
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599919 911 SGIPkaimdqlfepffttKDPGKGTGLGLALVYSIVEEHYGQITIESPTDhqreGGTRFRVTLPRHP 977
Cdd:COG4585 203 VGFD--------------PEAAPGGGLGLRGMRERAEALGGTLTIGSAPG----GGTRVRATLPLAA 251
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
868-974 |
7.72e-05 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 44.50 E-value: 7.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 868 QRLAQVLINLLSNARDAS------------PPGGAIRVRSEASEHTVDLVVEDEGSGI------PKAI------------ 917
Cdd:cd16916 37 EKLADPLTHLLRNAVDHGieapeerlaagkPPEGTITLRAEHQGNQVVIEVSDDGRGIdrekirEKAIerglitadeaat 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599919 918 -----MDQL-FEPFFTTKDPG---KGTGLGLALVYSIVEEHYGQITIESptdhqREG-GTRFRVTLP 974
Cdd:cd16916 117 lsddeVLNLiFAPGFSTAEQVtdvSGRGVGMDVVKRSIESLGGTIEVES-----EPGqGTTFTIRLP 178
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
887-957 |
9.12e-05 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 43.30 E-value: 9.12e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599919 887 PGGAIRVRSEASEHTVDLVVEDEGSGIPKaiMDQLFEPFFTTKDPGKGTGLGlalvYSIVEEHYGQITIES 957
Cdd:cd16942 59 PNGIVSISVIIEDGVVHLTVRDEGVGIPD--IEEARQPLFTTKPELERSGMG----FTIMENFMDEVIVES 123
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
872-974 |
1.00e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 42.41 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 872 QVLI-NLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKdpgKGTGLGLALVYSIVEEHY 950
Cdd:cd16957 7 QVLVeNAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSE---KGTGTALENLNRRLIGLF 83
|
90 100
....*....|....*....|....*..
gi 15599919 951 GQIT---IESpTDHQregGTRFRVTLP 974
Cdd:cd16957 84 GSEAclhIES-EVHG---GTEVWFVIP 106
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
732-980 |
1.02e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 46.46 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 732 VLLVEDLTETQLLEDKLVHSERlasigRLAAGVAHEIGNPITGIACLAQNLREEREGDGElTEISEQILDQTKRVSRIV- 810
Cdd:PRK10618 430 VLVNKKLQQAQREYEKNQQARK-----AFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQ-QPELDQLAEQSDVLVRLVd 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 811 ----------QSLMSFAHSGShLQALepvcLSEVAQEAigLLSLNRRSVEVEFFNLCDPAHWVEGDSQRLAQVLINLLSN 880
Cdd:PRK10618 504 niqllnmletQDWKPEQELFS-LQDL----IDEVLPEV--LPAIKRKGLQLLIHNHLKAEQLRIGDRDALRKILLLLLNY 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 881 ARdASPPGGAIRVRSEASEHTVD-LVVE--DEGSGIPKAIMDQLFEPFF--TTKDP-GKGTGLGLALVYSIVEEHYGQIT 954
Cdd:PRK10618 577 AI-TTTAYGKITLEVDQDESSPDrLTIRilDTGAGVSIKELDNLHFPFLnqTQGDRyGKASGLTFFLCNQLCRKLGGHLT 655
|
250 260
....*....|....*....|....*..
gi 15599919 955 IESptdhqREG-GTRFRVTLPRHPGPT 980
Cdd:PRK10618 656 IKS-----REGlGTRYSIHLKMLAADP 677
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
872-974 |
2.66e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 41.28 E-value: 2.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 872 QVLI-NLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLfepfftTKDPGKGTGLGLALVYSIVEEHY 950
Cdd:cd16924 7 QPLVeNAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNIL------GKKPKEGNGIGLYNVHQRLILLF 80
|
90 100
....*....|....*....|....*..
gi 15599919 951 GQ---ITIESPTDhqreGGTRFRVTLP 974
Cdd:cd16924 81 GEdygIHIASEPD----KGTRITFTIP 103
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
873-977 |
2.93e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 44.66 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 873 VLINLLSNARDASPPGGA---IRVR-SEASEHTVDLVVEDEGSGIPKAImdqlfepffttkDPGKGTGLGLALVYSIVEE 948
Cdd:PRK13560 715 IISELLSNALKHAFPDGAagnIKVEiREQGDGMVNLCVADDGIGLPAGF------------DFRAAETLGLQLVCALVKQ 782
|
90 100
....*....|....*....|....*....
gi 15599919 949 HYGQITIESptdhqrEGGTRFRVTLPRHP 977
Cdd:PRK13560 783 LDGEIALDS------RGGARFNIRFPMSP 805
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
46-437 |
8.95e-04 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 42.67 E-value: 8.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 46 LSLGV-YASAWAFYGTVGLAYQYGygfLAIYLGISGAFLLAPVLLYPILRVTRAYQLSSLADLFAFRFRS---TWAGALT 121
Cdd:TIGR00813 12 ASLFAsYISASQFLGLPGAIYAYG---FAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKrilRGLSVLS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 122 TLFMLIGVLPML----ALQIQAVTdSISILTrdpaqervAFVFCTLITLFAILFGarhiatrerheGLVFAIAFESLVKL 197
Cdd:TIGR00813 89 LILYIFLYMSVDlfsgALLIELIT-GLDLYL--------SLLLLGAITILYTVFG-----------GLKAVVWTDTIQAV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 198 VMLgsIGLYAL-YGVFGGPEGLEVWLLQNQTALTTLHTP-----LAEGPwRTLLLVFFAAAIVMPHMFHMIFTENLNPRA 271
Cdd:TIGR00813 149 IMI--LGTFILpVFAFSEVGGLGTFVEKASQAAPTNPSPddlydFFRDP-STSDLPWGAGVFGLPHVALWYWTNQVIVQR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 272 LISA----SWGLPLFLLLMSLAVPPIL-----WAGLRLGASTTPEYYTIGLGLAVDS-PALALA---AFIGGISAASGLT 338
Cdd:TIGR00813 226 CLAAksakHAKKGCLISGVLKLLPMFGavlpgLIARALYTDIDPALAGAVNQNSDQAyPLLVQElmpPGLAGLFLAAILA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 339 IVMT------LALSGMVLNHLVLPLYQPPAQGNiyrwLKWTRRLLIVAIIMASYAfyLLLGAEQDLSNLGIVSFV---AT 409
Cdd:TIGR00813 306 AVMStlssqlNSASTVFTMDLYKKIIRPNASGE----KKIVMRGRIAVLVAAVIA--GFVAAAQGGQVLQYVQEAfggLG 379
|
410 420
....*....|....*....|....*...
gi 15599919 410 LQFLPGALSVLYWPTANRRGFISGLIAG 437
Cdd:TIGR00813 380 APFLPVFLLGIFWKRMNAKGALAGMIAG 407
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
97-467 |
1.82e-03 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 42.13 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 97 RAYQLSSLADLFAFRFrSTWAGALTTLFMLIGVLPMLALQIQAVTDSISILTRDPaqERVAFVFCTLITLFAILFGarhi 176
Cdd:cd11474 92 RRMGLLTLGDFFRQRY-GRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLP--VETGILISAAIVLAYTLFG---- 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 177 atrerheGLvFAIAFESLVKLVMLgSIGL-YALYGVFGGPEGLEVwllQNQTALTTLHTPLAEGPWRTLLlVFFAAAIVM 255
Cdd:cd11474 165 -------GM-WSVAYTDVVQLIVI-FVGLlVLVPFVLTNPGGVDI---ASAAAAGKLRFFPWLGTKSDWL-IWIDAWLTL 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 256 phMFHMIFTENLNPRALISAS-----WGLPLFLLL-MSLAVPPILWAGLrlGASTTPEYYTIGLGLAVD----------S 319
Cdd:cd11474 232 --GLGSIPQQDVFQRVLSAKSektaqRLSLLAGVGyLLFAIPPLLIGLA--AASIDPSLTQYGLEEDAQlilplllqylT 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 320 PALALAAFIGGISAAsgltiVMT------LALSGMVLNHLVLPLYQPPAQGniyRWLKWTRRLLIVAIIMASYAF----- 388
Cdd:cd11474 308 PLWVQVLFLGALLSA-----VMStadsalLAPSSVFSENIYKPPFRPKASD---RELLWVMRISVVVFGAIATLMaltve 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 389 --YLLLGAEQDLSNLGIvsFVatlQFLpgalSVLYWPTANRRGFISGLIAGMLVWAI----TMLLPLMGNVQGLYLPLFD 462
Cdd:cd11474 380 siYGLVELASDLVLVGL--FV---PLL----AGLYWKRANTYGALAAIIVGLVLRLLggelLLGLPADIPPQLQGFPFST 450
|
....*
gi 15599919 463 VIYVL 467
Cdd:cd11474 451 LAMVI 455
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
632-748 |
2.96e-03 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 38.81 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 632 RYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSAL--PEPWKGLLERF--IDAPDEHLH-KQRLVY 706
Cdd:TIGR00229 3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELipEEDREEVRERIerRLEGEPEPVsEERRVR 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 15599919 707 --DGHTRWLNLHKAAIEEplAPGNSGLVLLVEDLTETQLLEDKL 748
Cdd:TIGR00229 83 rkDGSEIWVEVSVSPIRT--NGGELGVVGIVRDITERKEAEEAL 124
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
635-683 |
5.61e-03 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 36.22 E-value: 5.61e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 15599919 635 RQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEP 683
Cdd:smart00091 4 RAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHP 52
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
641-738 |
9.97e-03 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 36.84 E-value: 9.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599919 641 LPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSAL-PEPWKGLLERFIDAPDEHLHKQRLVY-----DGHTRWLN 714
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLiHPEDREELRERLENLLSGGEPVTLEVrlrrkDGSVIWVL 80
|
90 100
....*....|....*....|....
gi 15599919 715 LHKAAIEEPlAPGNSGLVLLVEDL 738
Cdd:cd00130 81 VSLTPIRDE-GGEVIGLLGVVRDI 103
|
|
| |
