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Conserved domains on  [gi|15599978|ref|NP_253472|]
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transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-133 1.63e-44

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 142.61  E-value: 1.63e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599978   1 MDKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVITGYHASVNLAKLGLPIECVIELRITEKDCQSVL 80
Cdd:COG1522   3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFA 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15599978  81 DELARIPQLTLCHRITGDACVLMKAAVASMPELQDLIDRLMK--FGISKTSMILS 133
Cdd:COG1522  83 EALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAalPGVRRTETSFV 137
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-133 1.63e-44

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 142.61  E-value: 1.63e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599978   1 MDKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVITGYHASVNLAKLGLPIECVIELRITEKDCQSVL 80
Cdd:COG1522   3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFA 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15599978  81 DELARIPQLTLCHRITGDACVLMKAAVASMPELQDLIDRLMK--FGISKTSMILS 133
Cdd:COG1522  83 EALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAalPGVRRTETSFV 137
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-107 5.59e-30

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 104.91  E-value: 5.59e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599978      1 MDKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVITGYHASVNLAKLGLPIECVIELRI-TEKDCQSV 79
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLeNPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 15599978     80 LDELARIPQLTLCHRITGDACVLMKAAV 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-120 3.48e-19

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 78.60  E-value: 3.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599978    1 MDKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVITGYHASVNLAKLGLPIECVIELRI-TEKDCQSV 79
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILkSAKDYPSA 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 15599978   80 LDELARIPQLTLCHRITGDACVLMKAAVASMPELQD-LIDRL 120
Cdd:PRK11179  87 LAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHvLINKI 128
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 1.99e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 60.46  E-value: 1.99e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15599978     2 DKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-50 1.42e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.83  E-value: 1.42e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15599978   2 DKYDRALLAALIDNGrLTFAELARRINLSPPAVADRVAKLEAEGVITGY 50
Cdd:cd00090   6 DPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-133 1.63e-44

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 142.61  E-value: 1.63e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599978   1 MDKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVITGYHASVNLAKLGLPIECVIELRITEKDCQSVL 80
Cdd:COG1522   3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFA 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15599978  81 DELARIPQLTLCHRITGDACVLMKAAVASMPELQDLIDRLMK--FGISKTSMILS 133
Cdd:COG1522  83 EALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAalPGVRRTETSFV 137
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-107 5.59e-30

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 104.91  E-value: 5.59e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599978      1 MDKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVITGYHASVNLAKLGLPIECVIELRI-TEKDCQSV 79
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLeNPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 15599978     80 LDELARIPQLTLCHRITGDACVLMKAAV 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-120 3.48e-19

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 78.60  E-value: 3.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599978    1 MDKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVITGYHASVNLAKLGLPIECVIELRI-TEKDCQSV 79
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILkSAKDYPSA 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 15599978   80 LDELARIPQLTLCHRITGDACVLMKAAVASMPELQD-LIDRL 120
Cdd:PRK11179  87 LAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHvLINKI 128
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-128 3.54e-19

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 79.03  E-value: 3.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599978    1 MDKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVITGYHASVNLAKLGLPIECVIELRITeKDCQSVL 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLN-RGAPDVF 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15599978   81 DELARIPQL----TLCHRITGDACVLMKAAVASMPELQDLI-DRLMKF-GISKT 128
Cdd:PRK11169  91 EQFNAAVQKleeiQECHLVSGDFDYLLKTRVPDMSAYRKLLgETLLRLpGVNDT 144
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 1.99e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 60.46  E-value: 1.99e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15599978     2 DKYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
3-47 7.83e-13

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 58.98  E-value: 7.83e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15599978     3 KYDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVI 47
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 67-134 2.97e-12

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 58.31  E-value: 2.97e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599978    67 IELRIT-EKDCQSVLDELARIPQLTLCHRITGDACVLMKAAVASMPELQDL----IDRLMKFGISKTSMILST 134
Cdd:pfam01037   1 VEVKLEpGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFlrekLRSLPGVARTETSIVLST 73
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
4-48 4.01e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 46.80  E-value: 4.01e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15599978   4 YDRALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:COG3398  98 TPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVE 142
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-50 1.42e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.83  E-value: 1.42e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15599978   2 DKYDRALLAALIDNGrLTFAELARRINLSPPAVADRVAKLEAEGVITGY 50
Cdd:cd00090   6 DPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 7-48 1.35e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 40.65  E-value: 1.35e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15599978     7 ALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:pfam12802   9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVE 50
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
6-50 2.19e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 41.17  E-value: 2.19e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15599978   6 RALLAALIDnGRLTFAELARRINLSPPAVADRVAKLEAEGVITGY 50
Cdd:COG1777  20 RRILALLSE-EPAYVSELARELGVSRQAVYKHLRKLEEAGLVESY 63
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
8-48 2.53e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.34  E-value: 2.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15599978      8 LLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVR 55
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
8-48 3.71e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 38.41  E-value: 3.71e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15599978   8 LLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:COG1846  43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 8-48 5.96e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.99  E-value: 5.96e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15599978     8 LLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:pfam01047   8 ILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIE 48
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-48 7.11e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 38.37  E-value: 7.11e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15599978   6 RALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:COG2345  16 RRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE 58
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 5-48 3.08e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 34.89  E-value: 3.08e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15599978   5 DRALLAALIDN-GRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:COG2512  17 ERRVLELLRENgGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 6-48 3.23e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 34.05  E-value: 3.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15599978     6 RALLAALIDNGRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:pfam12840  13 LRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVE 55
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
14-48 6.51e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 34.79  E-value: 6.51e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15599978  14 DNGRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:COG1321  21 EGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVE 55
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
15-48 6.76e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 33.34  E-value: 6.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 15599978     15 NGRLTFAELARRINLSPPAVADRVAKLEAEGVIT 48
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVE 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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