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Conserved domains on  [gi|15600225|ref|NP_253719|]
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transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12117701)

AraC family transcriptional regulator containing an AraC family HTH domain and an N-terminal arabinose binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence.

Gene Ontology:  GO:0003700

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 30-207 2.18e-35

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


:

Pssm-ID: 432679  Cd Length: 185  Bit Score: 127.37  E-value: 2.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225    30 DGRALLREIGLSTLRLEEPEARVTSQQYQAIAATALALSGDPDLGAQLALRTPPTAHGSLGYAMMASATLGDALCLALRY 109
Cdd:pfam12625   3 DPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLLRY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225   110 MPLLQGNVEISLL-REDEQVILRMLPgPALPPALHRYFSEALLIGLYRSGAWLLGEPALVGRLDFDYPEPAVPVPLP--- 185
Cdd:pfam12625  83 LRLLSDALELRLEeGEGGLARLRLDV-RPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYErlf 161

                         170       180
                  ....*....|....*....|....
gi 15600225   186 --QCRYDQAHVQLVFPAILLARSL 207
Cdd:pfam12625 162 gcPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
252-333 4.67e-22

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 88.76  E-value: 4.67e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225    252 PNLEEVAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPS 330
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 15600225    331 DTR 333
Cdd:smart00342  82 EYR 84
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 30-207 2.18e-35

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 127.37  E-value: 2.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225    30 DGRALLREIGLSTLRLEEPEARVTSQQYQAIAATALALSGDPDLGAQLALRTPPTAHGSLGYAMMASATLGDALCLALRY 109
Cdd:pfam12625   3 DPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLLRY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225   110 MPLLQGNVEISLL-REDEQVILRMLPgPALPPALHRYFSEALLIGLYRSGAWLLGEPALVGRLDFDYPEPAVPVPLP--- 185
Cdd:pfam12625  83 LRLLSDALELRLEeGEGGLARLRLDV-RPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYErlf 161

                         170       180
                  ....*....|....*....|....
gi 15600225   186 --QCRYDQAHVQLVFPAILLARSL 207
Cdd:pfam12625 162 gcPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
252-333 4.67e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 88.76  E-value: 4.67e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225    252 PNLEEVAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPS 330
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 15600225    331 DTR 333
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
142-336 4.74e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.08  E-value: 4.74e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225 142 LHRYFSEALLIGLYRSGAWLLGEPALVGRLDFDYPEPAVPVPLPQCRYDQAHVQLVFPAILLARSLPMADPAALRRAREH 221
Cdd:COG2207  59 LLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLL 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225 222 CERELALLDAGRRDICARVRLELERQEQRFPNLEEVAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLLRRPEV 300
Cdd:COG2207 139 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDL 218

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15600225 301 SLQRIALYLGYSDPTNFTRAFKRWTGEPPSDTRARL 336
Cdd:COG2207 219 SISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
HTH_18 pfam12833
Helix-turn-helix domain;
257-335 1.69e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.87  E-value: 1.69e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225   257 VAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLL-RRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDTRA 334
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 15600225   335 R 335
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 254-342 4.42e-12

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 65.95  E-value: 4.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225 254 LEEVAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDT 332
Cdd:COG4977 229 VDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAY 308

                        90
                ....*....|
gi 15600225 333 RARLLGGQPV 342
Cdd:COG4977 309 RRRFRARAAA 318
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 254-347 6.38e-09

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 56.09  E-value: 6.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  254 LEEVAARLHLSSRSLKRHLHDAGTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDTR 333
Cdd:PRK09978 161 LARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240

                         90
                 ....*....|....
gi 15600225  334 ARLLGGQPVSRTNA 347
Cdd:PRK09978 241 ERSAQGLPNRDSAA 254
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 30-207 2.18e-35

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 127.37  E-value: 2.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225    30 DGRALLREIGLSTLRLEEPEARVTSQQYQAIAATALALSGDPDLGAQLALRTPPTAHGSLGYAMMASATLGDALCLALRY 109
Cdd:pfam12625   3 DPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLLRY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225   110 MPLLQGNVEISLL-REDEQVILRMLPgPALPPALHRYFSEALLIGLYRSGAWLLGEPALVGRLDFDYPEPAVPVPLP--- 185
Cdd:pfam12625  83 LRLLSDALELRLEeGEGGLARLRLDV-RPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYErlf 161

                         170       180
                  ....*....|....*....|....
gi 15600225   186 --QCRYDQAHVQLVFPAILLARSL 207
Cdd:pfam12625 162 gcPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
252-333 4.67e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 88.76  E-value: 4.67e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225    252 PNLEEVAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPS 330
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 15600225    331 DTR 333
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
142-336 4.74e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.08  E-value: 4.74e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225 142 LHRYFSEALLIGLYRSGAWLLGEPALVGRLDFDYPEPAVPVPLPQCRYDQAHVQLVFPAILLARSLPMADPAALRRAREH 221
Cdd:COG2207  59 LLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLL 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225 222 CERELALLDAGRRDICARVRLELERQEQRFPNLEEVAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLLRRPEV 300
Cdd:COG2207 139 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDL 218

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15600225 301 SLQRIALYLGYSDPTNFTRAFKRWTGEPPSDTRARL 336
Cdd:COG2207 219 SISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
HTH_18 pfam12833
Helix-turn-helix domain;
257-335 1.69e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.87  E-value: 1.69e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225   257 VAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLL-RRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDTRA 334
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 15600225   335 R 335
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 254-342 4.42e-12

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 65.95  E-value: 4.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225 254 LEEVAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDT 332
Cdd:COG4977 229 VDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAY 308

                        90
                ....*....|
gi 15600225 333 RARLLGGQPV 342
Cdd:COG4977 309 RRRFRARAAA 318
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 254-347 6.38e-09

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 56.09  E-value: 6.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  254 LEEVAARLHLSSRSLKRHLHDAGTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDTR 333
Cdd:PRK09978 161 LARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240

                         90
                 ....*....|....
gi 15600225  334 ARLLGGQPVSRTNA 347
Cdd:PRK09978 241 ERSAQGLPNRDSAA 254
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 254-330 1.36e-08

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 55.39  E-value: 1.36e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15600225  254 LEEVAARLHLSSRSLKRHLHDAGTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPS 330
Cdd:PRK15185 225 LTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPS 301
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 254-340 2.04e-08

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 54.69  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  254 LEEVAARLHLSSRSLKRHLHDAGTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDTR 333
Cdd:PRK15186 200 LKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFL 279


                 ....*..
gi 15600225  334 ARLLGGQ 340
Cdd:PRK15186 280 AFLSSSR 286
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
254-335 2.09e-08

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 54.98  E-value: 2.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  254 LEEVAARLHLSSRSLKrHLhdagtsFRQLLGQA------RQR--QALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWT 325
Cdd:PRK10572 202 IESVAQHVCLSPSRLA-HL------FRQQLGISvlrwreDQRisRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCT 274

                         90
                 ....*....|
gi 15600225  326 GEPPSDTRAR 335
Cdd:PRK10572 275 GASPSEFRAR 284
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 256-323 4.66e-07

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 50.80  E-value: 4.66e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15600225  256 EVAARLHLSSRSLKRHLHDAGTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKR 323
Cdd:PRK15044 213 EVAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYFIAIFKR 280
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 222-335 3.38e-06

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 48.51  E-value: 3.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225 222 CERELALLDAGRRDICARVRLELERQEQRFPNLEEVAARLHLSS----RSLKRHLhdaGTSFRQLLGQARQRQALRLLRR 297
Cdd:COG2169  71 CRPDLAPGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPrhlrRLFKAHT---GVTPKAYARARRLLRARQLLQT 147

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15600225 298 PEvSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDTRAR 335
Cdd:COG2169 148 GL-SVTDAAYAAGFGSLSRFYEAFKKLLGMTPSAYRRG 184
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 222-329 9.18e-06

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 46.62  E-value: 9.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  222 CERELALLDAGRRDICARVRLELERQEQRFPNLEEVAARLHLSSRSLKRHLHDAGTSFRQLLGQARQRQALRLLrRPEVS 301
Cdd:PRK09940 121 CKGFITLLTNGVLSVSGKVRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLI-RVEGS 199

                         90       100
                 ....*....|....*....|....*...
gi 15600225  302 LQRIALYLGYSDPTNFTRAFKRWTGEPP 329
Cdd:PRK09940 200 VNKIAEQCGYASTSYFIYAFRKHFGNSP 227
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 252-337 7.12e-05

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 43.87  E-value: 7.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  252 PNL--EEVAARLHLSSRSLKRHLHDAGTSFRQLLGQARQR---QALRLLRRPEvSLQRIALYLGYSDPTNFTRAFKRWTG 326
Cdd:PRK09685 213 EILrpEWIAGELGISVRSLYRLFAEQGLVVAQYIRNRRLDrcaDDLRPAADDE-KITSIAYKWGFSDSSHFSTAFKQRFG 291

                         90
                 ....*....|.
gi 15600225  327 EPPSDTRARLL 337
Cdd:PRK09685 292 VSPGEYRRKFR 302
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
253-333 1.39e-04

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 43.13  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  253 NLEEVAARLHLSSRSLKRHL-HDAGTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSD 331
Cdd:PRK13503 189 NWEALADQFSLSLRTLHRQLkQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRD 268


                 ..
gi 15600225  332 TR 333
Cdd:PRK13503 269 IR 270
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
253-336 1.76e-04

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 40.29  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  253 NLEEVAARLHLSSRSLKRHLHdagTSFRQLLGQ-ARQR------QALRLLRRPevsLQRIALYLGYSDPTNFTRAFKRWT 325
Cdd:PRK10219  23 NIDVVAKKSGYSKWYLQRMFR---TVTHQTLGDyIRQRrlllaaVELRTTERP---IFDIAMDLGYVSQQTFSRVFRRQF 96

                         90
                 ....*....|.
gi 15600225  326 GEPPSDTRARL 336
Cdd:PRK10219  97 DRTPSDYRHRL 107
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
215-336 5.53e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 41.43  E-value: 5.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  215 LRRAREHCERELALLDAGRRDIcarVRLELERQEQRFPNLEEVAARLHLSSRSLKrHL--HDAGTSFRQLLGQARQRQAL 292
Cdd:PRK13501 159 LKRHRYRAEQAHLLPDGEQLDL---IMSALQQSLGAYFDMADFCHKNQLVERSLK-QLfrQQTGMSISHYLRQIRLCHAK 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 15600225  293 RLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDTRARL 336
Cdd:PRK13501 235 CLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQRF 278
ftrA PRK09393
transcriptional activator FtrA; Provisional
 254-335 1.06e-03

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 40.33  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600225  254 LEEVAARLHLSSRSLKRHLHDA-GTSFRQLLGQARQRQALRLLRRPEVSLQRIALYLGYSDPTNFTRAFKRWTGEPPSDT 332
Cdd:PRK09393 237 VASLAARAAMSPRTFLRRFEAAtGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATSPAAY 316


                 ...
gi 15600225  333 RAR 335
Cdd:PRK09393 317 RKR 319
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 299-333 1.90e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.59  E-value: 1.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15600225   299 EVSLQRIALYLGYSdPTNFTRAFKRWTGEPPSDTR 333
Cdd:pfam00165   8 NLTIADIADELGFS-RSYFSRLFKKYTGVTPSQYR 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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