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Conserved domains on  [gi|15600352|ref|NP_253846|]
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multidrug resistance protein [Pseudomonas aeruginosa PAO1]

Protein Classification

HlyD/EmrA/EmrK family protein( domain architecture ID 1001740)

HlyD/EmrA/EmrK family protein belongs to a family of membrane fusion proteins (MFPs) from proteobacteria that includes the multidrug resistance protein MdtN and the efflux pump membrane proteins EmrA and EmrK

Gene Ontology:  GO:0055085
PubMed:  12501312|12482849

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CusB_dom_1 super family cl46872
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 14-383 1.62e-159

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


The actual alignment was detected with superfamily member PRK15136:

Pssm-ID: 481212 [Multi-domain]  Cd Length: 390  Bit Score: 453.77  E-value: 1.62e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   14 KRKRWLLILLAMIVLATLASVAWEFFYGRWHEDTDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDAD 93
Cdd:PRK15136  19 KRKRALLLLTLLFIIIGVAYGIYWFLVLRHHQETDDAYVAGNQVQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   94 IALQRAEANLAHTVRQVRGLFSNVDGYRAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHARDALDSAKASLTSSE 173
Cdd:PRK15136  99 QAFEKAKTALANSVRQTHQLMINSKQYQANIELQKTALAQAQSDLNRRVPLGNANLIGREELQHARDAVASAQAQLDVAI 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  174 QQLNTNRALVDDTQITSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALMAVVPLDQIWIDANF 253
Cdd:PRK15136 179 QQYNANQAMILNTPLEDQPAVQQAATEVRNAWLALQRTKIVSPMTGYVSRRSVQVGAQISPTTPLMAVVPATNLWVDANF 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  254 KETQLKHMRIGQPVEIRSDLYGSDVRYSGTVDSLGVGTGSAFSLLPAQNATGNWIKIVQRVPVRIHIDPQELQKHPLRIG 333
Cdd:PRK15136 259 KETQLANMRIGQPATITSDIYGDDVVYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDAKQLAQHPLRIG 338

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 15600352  334 LSMDVKVDLHDQSGPALAQQPPREALFSTDVYQQQLASADKLIERLIEAN 383
Cdd:PRK15136 339 LSTLVTVDTANRDGQVLANQVRSTPAYESNALEIDLAPVNKLIDDIIQAN 388
 
Name Accession Description Interval E-value
PRK15136 PRK15136
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
14-383 1.62e-159

multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;


Pssm-ID: 185090 [Multi-domain]  Cd Length: 390  Bit Score: 453.77  E-value: 1.62e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   14 KRKRWLLILLAMIVLATLASVAWEFFYGRWHEDTDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDAD 93
Cdd:PRK15136  19 KRKRALLLLTLLFIIIGVAYGIYWFLVLRHHQETDDAYVAGNQVQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   94 IALQRAEANLAHTVRQVRGLFSNVDGYRAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHARDALDSAKASLTSSE 173
Cdd:PRK15136  99 QAFEKAKTALANSVRQTHQLMINSKQYQANIELQKTALAQAQSDLNRRVPLGNANLIGREELQHARDAVASAQAQLDVAI 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  174 QQLNTNRALVDDTQITSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALMAVVPLDQIWIDANF 253
Cdd:PRK15136 179 QQYNANQAMILNTPLEDQPAVQQAATEVRNAWLALQRTKIVSPMTGYVSRRSVQVGAQISPTTPLMAVVPATNLWVDANF 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  254 KETQLKHMRIGQPVEIRSDLYGSDVRYSGTVDSLGVGTGSAFSLLPAQNATGNWIKIVQRVPVRIHIDPQELQKHPLRIG 333
Cdd:PRK15136 259 KETQLANMRIGQPATITSDIYGDDVVYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDAKQLAQHPLRIG 338

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 15600352  334 LSMDVKVDLHDQSGPALAQQPPREALFSTDVYQQQLASADKLIERLIEAN 383
Cdd:PRK15136 339 LSTLVTVDTANRDGQVLANQVRSTPAYESNALEIDLAPVNKLIDDIIQAN 388
8a0101 TIGR00998
efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, ...
 15-340 5.91e-127

efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, Other]


Pssm-ID: 273385 [Multi-domain]  Cd Length: 334  Bit Score: 369.12  E-value: 5.91e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    15 RKRWLLILLAMIVLATLASVAWEFFYGRWHEDTDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADI 94
Cdd:TIGR00998   1 RKYFLLLLVVLLIVVAGAYAIYWFLVLRDYESTDDAYVKANQLQVSSQVSGSVIEVNVDDTDYVKQGDVLVRLDPTNAEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    95 ALQRAEANLAHTVRQVRGLFSNVDGYRAEVATRKVALAKA-------EADYKRRKNLADDGAISQEELAHARDALDSAKA 167
Cdd:TIGR00998  81 ALAKAEANLAALVRQTKQLEITVQQLQAKVESLKIKLEQArekllqaELDLRRRVPLFKKGLISREELDHARKALLSAKA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   168 SLTSS-EQQLNTNRALVDDTQITSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALMAVVPLDQ 246
Cdd:TIGR00998 161 ALNAAiQEQLNANQALVRGTPLKKQPAVQEAKERLKTAWLALKRTVIRAPFDGYVARRFVQVGQVVSPGQPLMAVVPAEQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   247 IWIDANFKETQLKHMRIGQPVEIRSDLYGSDVRYSGTVDSLGVGTGSAFSLLPAQNATGNWIKIVQRVPVRIHIDPQELQ 326
Cdd:TIGR00998 241 MYVEANFKETQLKNVRIGQPVTIRSDLYGSDVVFEGKVTGISMGTGSAFSLLPAQNATGNWIKVVQRLPVRIKLDPKELD 320

                         330
                  ....*....|....
gi 15600352   327 KHPLRIGLSMDVKV 340
Cdd:TIGR00998 321 EHPLRIGLSAEVEI 334
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
12-343 1.70e-88

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 270.77  E-value: 1.70e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  12 NPKRKRWLLILLAMIVLatlasVAWEFFYGRWHED---TDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFD 88
Cdd:COG1566   3 ALKKRRLLALVLLLLAL-----GLALWAAGRNGPDepvTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  89 PSDADIALQRAEANLAHTVRQVRGLFSN------VDGYRAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHARDAL 162
Cdd:COG1566  78 PTDLQAALAQAEAQLAAAEAQLARLEAElgaeaeIAAAEAQLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARAAL 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352 163 DSAKASLTSSEQQLNTNRALVD--DTQITSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALMA 240
Cdd:COG1566 158 DAAQAQLEAAQAQLAQAQAGLReeEELAAAQAQVAQAEAALAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLT 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352 241 VVPLDQIWIDANFKETQLKHMRIGQPVEIRSDLYGsDVRYSGTVDSLGVGTGSAFsllPAQNATGNwikIVQRVPVRIHI 320
Cdd:COG1566 238 IVPLDDLWVEAYVPETDLGRVKPGQPVEVRVDAYP-DRVFEGKVTSISPGAGFTS---PPKNATGN---VVQRYPVRIRL 310

                       330       340
                ....*....|....*....|...
gi 15600352 321 DPQELqkHPLRIGLSMDVKVDLH 343
Cdd:COG1566 311 DNPDP--EPLRPGMSATVEIDTE 331
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 40-342 5.44e-65

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 209.97  E-value: 5.44e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    40 YGRWHEDTDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADIALQRAEANLAHTVRQVRGLFSNVDG 119
Cdd:pfam00529   4 LTKGVEAPGRVVVSGNAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELDR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   120 Y------------------------RAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHARDALDSAKASLTSSEQQ 175
Cdd:pfam00529  84 LqaleselaisrqdydgataqlraaQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVAQ 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   176 L-----------NTNRALVDDTQITSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQV-GQRVQPGNALMAVVP 243
Cdd:pfam00529 164 LdqiyvqitqsaAENQAEVRSELSGAQLQIAEAEAELKLAKLDLERTEIRAPVDGTVAFLSVTVdGGTVSAGLRLMFVVP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   244 LDQIWIDANFKETQLKHMRIGQPVEIRSDLYGSDV--RYSGTVDSLGVGTGsafsllpaqnatgnwikivqrvPVRIHID 321
Cdd:pfam00529 244 EDNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKtgRFTGVVVGISPDTG----------------------PVRVVVD 301

                         330       340
                  ....*....|....*....|.
gi 15600352   322 PQELQKHPLRIGLSMDVKVDL 342
Cdd:pfam00529 302 KAQGPYYPLRIGLSAGALVRL 322
 
Name Accession Description Interval E-value
PRK15136 PRK15136
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
14-383 1.62e-159

multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;


Pssm-ID: 185090 [Multi-domain]  Cd Length: 390  Bit Score: 453.77  E-value: 1.62e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   14 KRKRWLLILLAMIVLATLASVAWEFFYGRWHEDTDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDAD 93
Cdd:PRK15136  19 KRKRALLLLTLLFIIIGVAYGIYWFLVLRHHQETDDAYVAGNQVQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   94 IALQRAEANLAHTVRQVRGLFSNVDGYRAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHARDALDSAKASLTSSE 173
Cdd:PRK15136  99 QAFEKAKTALANSVRQTHQLMINSKQYQANIELQKTALAQAQSDLNRRVPLGNANLIGREELQHARDAVASAQAQLDVAI 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  174 QQLNTNRALVDDTQITSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALMAVVPLDQIWIDANF 253
Cdd:PRK15136 179 QQYNANQAMILNTPLEDQPAVQQAATEVRNAWLALQRTKIVSPMTGYVSRRSVQVGAQISPTTPLMAVVPATNLWVDANF 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  254 KETQLKHMRIGQPVEIRSDLYGSDVRYSGTVDSLGVGTGSAFSLLPAQNATGNWIKIVQRVPVRIHIDPQELQKHPLRIG 333
Cdd:PRK15136 259 KETQLANMRIGQPATITSDIYGDDVVYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDAKQLAQHPLRIG 338

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 15600352  334 LSMDVKVDLHDQSGPALAQQPPREALFSTDVYQQQLASADKLIERLIEAN 383
Cdd:PRK15136 339 LSTLVTVDTANRDGQVLANQVRSTPAYESNALEIDLAPVNKLIDDIIQAN 388
8a0101 TIGR00998
efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, ...
 15-340 5.91e-127

efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, Other]


Pssm-ID: 273385 [Multi-domain]  Cd Length: 334  Bit Score: 369.12  E-value: 5.91e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    15 RKRWLLILLAMIVLATLASVAWEFFYGRWHEDTDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADI 94
Cdd:TIGR00998   1 RKYFLLLLVVLLIVVAGAYAIYWFLVLRDYESTDDAYVKANQLQVSSQVSGSVIEVNVDDTDYVKQGDVLVRLDPTNAEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    95 ALQRAEANLAHTVRQVRGLFSNVDGYRAEVATRKVALAKA-------EADYKRRKNLADDGAISQEELAHARDALDSAKA 167
Cdd:TIGR00998  81 ALAKAEANLAALVRQTKQLEITVQQLQAKVESLKIKLEQArekllqaELDLRRRVPLFKKGLISREELDHARKALLSAKA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   168 SLTSS-EQQLNTNRALVDDTQITSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALMAVVPLDQ 246
Cdd:TIGR00998 161 ALNAAiQEQLNANQALVRGTPLKKQPAVQEAKERLKTAWLALKRTVIRAPFDGYVARRFVQVGQVVSPGQPLMAVVPAEQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   247 IWIDANFKETQLKHMRIGQPVEIRSDLYGSDVRYSGTVDSLGVGTGSAFSLLPAQNATGNWIKIVQRVPVRIHIDPQELQ 326
Cdd:TIGR00998 241 MYVEANFKETQLKNVRIGQPVTIRSDLYGSDVVFEGKVTGISMGTGSAFSLLPAQNATGNWIKVVQRLPVRIKLDPKELD 320

                         330
                  ....*....|....
gi 15600352   327 KHPLRIGLSMDVKV 340
Cdd:TIGR00998 321 EHPLRIGLSAEVEI 334
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
12-343 1.70e-88

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 270.77  E-value: 1.70e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  12 NPKRKRWLLILLAMIVLatlasVAWEFFYGRWHED---TDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFD 88
Cdd:COG1566   3 ALKKRRLLALVLLLLAL-----GLALWAAGRNGPDepvTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  89 PSDADIALQRAEANLAHTVRQVRGLFSN------VDGYRAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHARDAL 162
Cdd:COG1566  78 PTDLQAALAQAEAQLAAAEAQLARLEAElgaeaeIAAAEAQLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARAAL 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352 163 DSAKASLTSSEQQLNTNRALVD--DTQITSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALMA 240
Cdd:COG1566 158 DAAQAQLEAAQAQLAQAQAGLReeEELAAAQAQVAQAEAALAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLT 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352 241 VVPLDQIWIDANFKETQLKHMRIGQPVEIRSDLYGsDVRYSGTVDSLGVGTGSAFsllPAQNATGNwikIVQRVPVRIHI 320
Cdd:COG1566 238 IVPLDDLWVEAYVPETDLGRVKPGQPVEVRVDAYP-DRVFEGKVTSISPGAGFTS---PPKNATGN---VVQRYPVRIRL 310

                       330       340
                ....*....|....*....|...
gi 15600352 321 DPQELqkHPLRIGLSMDVKVDLH 343
Cdd:COG1566 311 DNPDP--EPLRPGMSATVEIDTE 331
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 40-342 5.44e-65

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 209.97  E-value: 5.44e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    40 YGRWHEDTDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADIALQRAEANLAHTVRQVRGLFSNVDG 119
Cdd:pfam00529   4 LTKGVEAPGRVVVSGNAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELDR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   120 Y------------------------RAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHARDALDSAKASLTSSEQQ 175
Cdd:pfam00529  84 LqaleselaisrqdydgataqlraaQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVAQ 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   176 L-----------NTNRALVDDTQITSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQV-GQRVQPGNALMAVVP 243
Cdd:pfam00529 164 LdqiyvqitqsaAENQAEVRSELSGAQLQIAEAEAELKLAKLDLERTEIRAPVDGTVAFLSVTVdGGTVSAGLRLMFVVP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   244 LDQIWIDANFKETQLKHMRIGQPVEIRSDLYGSDV--RYSGTVDSLGVGTGsafsllpaqnatgnwikivqrvPVRIHID 321
Cdd:pfam00529 244 EDNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKtgRFTGVVVGISPDTG----------------------PVRVVVD 301

                         330       340
                  ....*....|....*....|.
gi 15600352   322 PQELQKHPLRIGLSMDVKVDL 342
Cdd:pfam00529 302 KAQGPYYPLRIGLSAGALVRL 322
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 55-363 4.02e-42

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 150.48  E-value: 4.02e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  55 NVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADIALQRAEANLAHTvrqvrglfsnvdgyraevatrKVALAKA 134
Cdd:COG0845  22 REVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAA---------------------QAQLELA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352 135 EADYKRRKNLADDGAISQEELAHARDALDSAKAsltsseqqlntnralvddtqitshpDVKAAAAQLRQAYLDDARSTIV 214
Cdd:COG0845  81 KAELERYKALLKKGAVSQQELDQAKAALDQAQA-------------------------ALAAAQAALEQARANLAYTTIR 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352 215 APVTGYVAKRSVQVGQRVQPGNALMAVVPLDQIWIDANFKETQLKHMRIGQPVEIRSDLYgSDVRYSGTVDSLGvgtgsa 294
Cdd:COG0845 136 APFDGVVGERNVEPGQLVSAGTPLFTIADLDPLEVEFDVPESDLARLKVGQPVTVTLDAG-PGKTFEGKVTFID------ 208

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15600352 295 fsllPAQNATgnwikiVQRVPVRIHIDPQElqkHPLRIGLSMDVKVDLhDQSGPALAQqpPREALFSTD 363
Cdd:COG0845 209 ----PAVDPA------TRTVRVRAELPNPD---GLLRPGMFVRVRIVL-GERENALLV--PASAVVRDG 261
PRK10476 PRK10476
multidrug transporter subunit MdtN;
7-340 2.20e-40

multidrug transporter subunit MdtN;


Pssm-ID: 182488 [Multi-domain]  Cd Length: 346  Bit Score: 146.33  E-value: 2.20e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    7 ETPAGNPKRKRWLLILLAMIVLATLASVAWEFfygRWHEDTDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVR 86
Cdd:PRK10476   2 ESTPKKSPRKKLPALAIVALAIVALVFVIWRT---DSAPSTDDAYIDADVVHVASEVGGRIVELAVTENQAVKKGDLLFR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   87 FDP-------SDADIALQRAEANLAHTVRQVRGLFSNVDGYRAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHAR 159
Cdd:PRK10476  79 IDPrpyeltvAQAQADLALADAQIMTTQRSVDAERSNAASANEQVERARANAKLATRTLERLEPLLAKGYVSAQQVDQAR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  160 DALDSAKASLTSSEQQLNTNRALVDDTQiTSHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALM 239
Cdd:PRK10476 159 TAQRDAEVSLNQALLQAQAAAAAVGGVD-ALVAQRAAREAALAIAELHLEDTTVRAPFDGRVVGLKVSVGEFAAPMQPIF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  240 AVVPLDQIWIDANFKETQLKHMRIGQPVEIRSdLYGSDVRYSGTVDSLGVGTGSAFSL-----LPAQNATGNWIKIVQRV 314
Cdd:PRK10476 238 TLIDTDHWYAIANFRETDLKNIRVGDCATVYS-MIDRGRPFEGKVDSIGWGVLPDDGGnvprgLPYVPRSINWVRVAQRF 316

                        330       340
                 ....*....|....*....|....*...
gi 15600352  315 PVRIHID--PQELqkhpLRIGLSMDVKV 340
Cdd:PRK10476 317 PVRIMLDkpDPEL----FRIGASAVVEL 340
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 54-287 4.07e-27

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 109.71  E-value: 4.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    54 GNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADIALQRAeanlahtvrqvrglfsnvdgyRAEVATRKVALAK 133
Cdd:TIGR01730  24 VDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAA---------------------LAQLAAAEAQLEL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   134 AEADYKRRKNLADDGAISQEELAHARDALDSAKAsltsseqqlntnralvddtqitshpDVKAAAAQLRQAYLDDARSTI 213
Cdd:TIGR01730  83 AQRSFERAERLVKRNAVSQADLDDAKAAVEAAQA-------------------------DLEAAKASLASAQLNLRYTEI 137

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15600352   214 VAPVTGYVAKRSVQVGQRVQPGNALMAVVPLDQIWIDANFKETQLKHMRIGQPVEIRSDLYGSDVrYSGTVDSL 287
Cdd:TIGR01730 138 RAPFDGTIGRRLVEVGAYVTAGQTLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEE-FKGKLRFI 210
PRK10559 PRK10559
p-hydroxybenzoic acid efflux pump subunit AaeA;
21-329 6.63e-26

p-hydroxybenzoic acid efflux pump subunit AaeA;


Pssm-ID: 182548 [Multi-domain]  Cd Length: 310  Bit Score: 106.36  E-value: 6.63e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   21 ILLAMIVLATLASV-AWEFFYGR-WhedTDDAYINGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADIALQR 98
Cdd:PRK10559  13 ITLVLVILAFIAIFrAWVFYTESpW---TRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQPRYQKALAE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   99 AEANLAHtvrqvrglfsnvdgYRAeVATRKvalaKAEAdyKRRKNLADDgAISQEELahardalDSAKASLTSSEQQLnt 178
Cdd:PRK10559  90 AEADVAY--------------YQV-LAQEK----RREA--GRRNRLGVQ-AMSREEI-------DQANNVLQTVLHQL-- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  179 nralvddtqitshpdvKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALMAVVPLDQIWIDANFKETQL 258
Cdd:PRK10559 139 ----------------AKAQATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKL 202

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15600352  259 KHMRIGQPVEIRSdlYGSDVRYSGTVDSLGVGTGSAFSL-----LPAQNATGNWIKIVQRVPVRIHIDPQELQKHP 329
Cdd:PRK10559 203 EGVRPGYRAEITP--LGSNKVLKGTVDSVAAGVTNSSSTrdskgMATIDSNLEWVRLAQRVPVRIRLDNQQGNLYP 276
PRK03598 PRK03598
putative efflux pump membrane fusion protein; Provisional
 14-284 9.78e-26

putative efflux pump membrane fusion protein; Provisional


Pssm-ID: 235136 [Multi-domain]  Cd Length: 331  Bit Score: 106.20  E-value: 9.78e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   14 KRKRWLLILLAMIVLATLASVAWeffygrWHEDTDDA-YINGNV----VQITPQIVGTVVSIGADDGDLVRKGQELVRFD 88
Cdd:PRK03598   2 KKKVVIGLAVVVLAAAVAGGWWW------YQSRQDNGlTLYGNVdirtVNLGFRVGGRLASLAVDEGDAVKAGQVLGELD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   89 PSDADIALQRAEANLAhtVRQVRgLFSNVDGYR--------AEVATRKVALAKAEADYKRRKNLADDGAISQEELAHARD 160
Cdd:PRK03598  76 AAPYENALMQAKANVS--VAQAQ-LDLMLAGYRdeeiaqarAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  161 ALDSAKASLTSSEQQLNTNRALVDDTQIT-SHPDVKAAAAQLRQAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPGNALM 239
Cdd:PRK03598 153 SRDQAQATLKSAQDKLSQYREGNRPQDIAqAKASLAQAQAALAQAELNLQDTELIAPSDGTILTRAVEPGTMLNAGSTVF 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 15600352  240 aVVPLDQ-IWIDANFKETQLKHMRIGQPVEIRSDlYGSDVRYSGTV 284
Cdd:PRK03598 233 -TLSLTRpVWVRAYVDERNLGQAQPGRKVLLYTD-GRPDKPYHGQI 276
type_I_hlyD TIGR01843
type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport ...
 53-343 3.44e-16

type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130902 [Multi-domain]  Cd Length: 423  Bit Score: 79.67  E-value: 3.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    53 NGNVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSD----------------ADIALQRAEAN-------------- 102
Cdd:TIGR01843  40 SGNVKVVQHLEGGIVREILVREGDRVKAGQVLVELDATDveadaaelesqvlrleAEVARLRAEADsqaaiefpddllsa 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   103 ----LAHTVRQVRGLF---------------SNVDGYRAEVATRKVALAKAEAD---YKRR----KNLADDGAISQEELA 156
Cdd:TIGR01843 120 edpaVPELIKGQQSLFesrkstlraqlelilAQIKQLEAELAGLQAQLQALRQQlevISEElearRKLKEKGLVSRLELL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   157 HARDALDSAKASLTSSEQQLNTNRALVDDTQI--------------TSHPDVKAAAAQLRQAY--LDD--ARSTIVAPVT 218
Cdd:TIGR01843 200 ELERERAEAQGELGRLEAELEVLKRQIDELQLerqqieqtfreevlEELTEAQARLAELRERLnkARDrlQRLIIRSPVD 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   219 GYVAKRSVQ-VGQRVQPGNALMAVVPL-DQIWIDANFKETQLKHMRIGQPVEIRSDLYGSdVRY---SGTVDSLGVgtgS 293
Cdd:TIGR01843 280 GTVQSLKVHtVGGVVQPGETLMEIVPEdDPLEIEAKLSPKDIGFVHVGQPAEIKFSAFPY-RRYgilNGKVKSISP---D 355

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15600352   294 AFSllpAQNATGNWIkivqrvPVRIHIDPQELQKHPLRIGLS--MDVKVDLH 343
Cdd:TIGR01843 356 TFT---DERGGGPYY------RVRISIDQNTLGIGPKGLELSpgMPVTADIK 398
HlyD_D23 pfam16576
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ...
 152-285 6.39e-16

Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.


Pssm-ID: 435440 [Multi-domain]  Cd Length: 214  Bit Score: 76.01  E-value: 6.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   152 QEELAHARDALDSAKAS--LTSSEQQLntnRAL-VDDTQItshpdvkaaaAQLRQAYLDDARSTIVAPVTGYVAKRSVQV 228
Cdd:pfam16576  60 QQEYLLALRSGDALSKSelLRAARQRL---RLLgMPEAQI----------AELERTGKVQPTVTVYAPISGVVTELNVRE 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15600352   229 GQRVQPGNALMAVVPLDQIWIDANFKETQLKHMRIGQPVEIRSDLYGsDVRYSGTVD 285
Cdd:pfam16576 127 GMYVQPGDTLFTIADLSTVWVEADVPEQDLALVKVGQPAEVTLPALP-GKTFEGKVD 182
heterocyst_DevB TIGR02971
ABC exporter membrane fusion protein, DevB family; Members of this protein family are found ...
 75-338 5.12e-14

ABC exporter membrane fusion protein, DevB family; Members of this protein family are found mostly in the Cyanobacteria, but also in the Planctomycetes. DevB from Anabaena sp. strain PCC 7120 is partially characterized as a membrane fusion protein of the DevBCA ABC exporter, probably a glycolipid exporter, required for heterocyst formation. Most Cyanobacteria have one member only, but Nostoc sp. PCC 7120 has seven members.


Pssm-ID: 213754 [Multi-domain]  Cd Length: 327  Bit Score: 72.17  E-value: 5.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    75 GDLVRKGQELVRFDPSDADIA-LQRAEANLAHTVR---QVRG------------------LFSNVDGYRAEVATRKVALA 132
Cdd:TIGR02971  35 GDRVQAGQVLAELDSRPERTAeLDVARTQLDEAKArlaQVRAgakkgeiaaqraaraaakLFKDVAAQQATLNRLEAELE 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   133 KAEADYKRRKNLADDGAISQEELAHARDALDSAKASLTS-----SEQQLNTNRALVDDTQITSHPDVKAAAAQLR----- 202
Cdd:TIGR02971 115 TAQREVDRYRSLFRDGAVSASDLDSKALKLRTAEEELEEalasrSEQIDGARAALASLAEEVRETDVDLAQAEVKsalea 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   203 --QAYLDDARSTIVAPVTGYVAKRSVQVGQRVQPgNALMAVVPLDQIWIDANFKETQLKHMRIGQPVEIRSDLYGSDVRy 280
Cdd:TIGR02971 195 vqQAEALLELTYVKAPIDGRVLKIHAREGEVIGS-EGILEMGDTSQMYAVAEVYETDINRVRVGQRATITSTALSGPLR- 272

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   281 sGTVDSLG--VGTGSAFSLLPAQNATGnwikivQRVPVRIHIDPQELQKHPLRIGLSMDV 338
Cdd:TIGR02971 273 -GTVRRIGslIAKNDVLSTDPAADADA------RVVEVKIRLDPASSERVGRLTNLQVDV 325
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
 212-333 1.29e-11

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 60.84  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   212 TIVAPVTGYVAKRSVQVGQRVQPGNALMAVVPLDQIWIDANFKETQLKHMRIGQPVEIRSDlYGSDVRYSGTVDSLGvgt 291
Cdd:pfam13437   1 TIRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLKKGQKVTLKLD-PGSDYTLEGKVVRIS--- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 15600352   292 gsafsllPAQNATGnwikivQRVPVRIHIDPQELQKhPLRIG 333
Cdd:pfam13437  77 -------PTVDPDT------GVIPVRVSIENPKTPI-PLLPG 104
PRK09859 PRK09859
multidrug transporter subunit MdtE;
56-250 1.90e-09

multidrug transporter subunit MdtE;


Pssm-ID: 137559 [Multi-domain]  Cd Length: 385  Bit Score: 58.96  E-value: 1.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   56 VVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADIALQRAEANLAHTVRqvrglfsnvdgyraevatrkvALAKAE 135
Cdd:PRK09859  61 VAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALS---------------------TASNAR 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  136 ADYKRRKNLADDGAISQEELAHARDALDSAKASLTsseqqlntnralvddtqitshpdvkAAAAQLRQAYLDDARSTIVA 215
Cdd:PRK09859 120 ITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVT-------------------------VAKAAVEQATINLQYANVTS 174

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 15600352  216 PVTGYVAKRSVQVGQRV--QPGNALMAVVPLDQIWID 250
Cdd:PRK09859 175 PITGVSGKSSVTVGALVtaNQADSLVTVQRLDPIYVD 211
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
55-248 4.78e-09

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 57.88  E-value: 4.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   55 NVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADIALQRAEANLAHTvrqvrglfsnvdgyraevatrKVALAKA 134
Cdd:PRK11556  86 NTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKD---------------------QATLANA 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  135 EADYKRRKNLADDGAISQeelahardaldsakasltsseQQLNTNRALVDDTQITSHPDVKA-AAAQLRQAYlddarSTI 213
Cdd:PRK11556 145 RRDLARYQQLAKTNLVSR---------------------QELDAQQALVSETEGTIKADEASvASAQLQLDY-----SRI 198

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 15600352  214 VAPVTGYVAKRSVQVGQRVQPGNALMAVV-----PLDQIW 248
Cdd:PRK11556 199 TAPISGRVGLKQVDVGNQISSGDTTGIVVitqthPIDLVF 238
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
 15-265 5.10e-07

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 51.31  E-value: 5.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   15 RKRWLLILlamIVLATLASVAWEFFYGRWHEDTDDAYINGNVVQ---------------ITPQIVGTVVSIGADDGDLVR 79
Cdd:PRK11578   8 KKRYLIAL---VIVLAGGITLWRILNAPVPTYQTLIVRPGDLQQsvlatgkldalrkvdVGAQVSGQLKTLSVAIGDKVK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   80 KGQELVRFDPSDADIALQRAEANLAHtvrqvrglfsnvdgYRAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHAR 159
Cdd:PRK11578  85 KDQLLGVIDPEQAENQIKEVEATLME--------------LRAQRQQAEAELKLARVTLSRQQRLAKTQAVSQQDLDTAA 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  160 DALDSAKASLTSSEQQLNTNRALVDDTQITshpdvkaaaaqlrqayLDDARstIVAPVTGYVAKRSVQVGQRV---QPGN 236
Cdd:PRK11578 151 TELAVKQAQIGTIDAQIKRNQASLDTAKTN----------------LDYTR--IVAPMAGEVTQITTLQGQTViaaQQAP 212

                        250       260
                 ....*....|....*....|....*....
gi 15600352  237 ALMAVVPLDQIWIDANFKETQLKHMRIGQ 265
Cdd:PRK11578 213 NILTLADMSTMLVKAQVSEADVIHLKPGQ 241
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
55-104 1.03e-06

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 45.13  E-value: 1.03e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 15600352    55 NVVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADIALQRAEANLA 104
Cdd:pfam13533   1 PVVKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEAQLA 50
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
56-250 1.93e-05

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 46.25  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352   56 VVQITPQIVGTVVSIGADDGDLVRKGQELVRFDPSDADIALQRAEANLAHTvrqvrglfsnvdgyraevatrKVALAKAE 135
Cdd:PRK15030  65 IAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKA---------------------QAAANIAQ 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352  136 ADYKRRKNLADDGAISQEELahardaldsakasltsseqqlntNRALVDDTQITShpDVKAAAAQLRQAYLDDARSTIVA 215
Cdd:PRK15030 124 LTVNRYQKLLGTQYISKQEY-----------------------DQALADAQQANA--AVTAAKAAVETARINLAYTKVTS 178

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 15600352  216 PVTGYVAKRSVQVGQRVQPG--NALMAVVPLDQIWID 250
Cdd:PRK15030 179 PISGRIGKSNVTEGALVQNGqaTALATVQQLDPIYVD 215
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
 92-181 8.45e-03

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 37.12  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600352    92 ADIALQRAEANLAHTVRQVR----GLFSNVDGYRAEVATRKVALAKAEADYKRRKNLADDGAISQEELAHARDALDSAKA 167
Cdd:pfam02321  81 AKAQVEAAEAQLEQARQQLRlevaQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEARL 160

                          90
                  ....*....|....
gi 15600352   168 SLTSSEQQLNTNRA 181
Cdd:pfam02321 161 ELLNAEADLELALA 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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