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Conserved domains on  [gi|15600443|ref|NP_253937|]
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hypothetical protein PA5250 [Pseudomonas aeruginosa PAO1]

Protein Classification

TerC family protein( domain architecture ID 10002902)

TerC family protein similar to Escherichia coli UPF0053 inner membrane protein YgdQ

Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
1-239 1.03e-56

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


:

Pssm-ID: 440622  Cd Length: 225  Bit Score: 180.63  E-value: 1.03e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443   1 MEWLAS-PEIWVAFLTLTALEIVLGIDNIIFISILVGRLPPAQQPKARFFGLALAMGTRILLLLSITWVMRLttDLFHLF 79
Cdd:COG0861   1 MDLLLFgPEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSF--PWILYL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443  80 GQGIsgrdLILffgglfllfKSTMEIYHSLEGAEEEQKSGGKVHGFMGIIVQIAIIDIIFSLDSVITAVGLVQNVPVMVA 159
Cdd:COG0861  79 GGLF----LLW---------TAIKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFT 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443 160 AIVISVGVMMLAAGTISDFIEKHPSLKMLALSFLIVVGTVLVAESFEVHVPKGYVYFAMAFSLAveALNIRLRGALARKR 239
Cdd:COG0861 146 GNIFAILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVL--ALGILASLLKRRKA 223
 
Name Accession Description Interval E-value
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
1-239 1.03e-56

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


Pssm-ID: 440622  Cd Length: 225  Bit Score: 180.63  E-value: 1.03e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443   1 MEWLAS-PEIWVAFLTLTALEIVLGIDNIIFISILVGRLPPAQQPKARFFGLALAMGTRILLLLSITWVMRLttDLFHLF 79
Cdd:COG0861   1 MDLLLFgPEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSF--PWILYL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443  80 GQGIsgrdLILffgglfllfKSTMEIYHSLEGAEEEQKSGGKVHGFMGIIVQIAIIDIIFSLDSVITAVGLVQNVPVMVA 159
Cdd:COG0861  79 GGLF----LLW---------TAIKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFT 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443 160 AIVISVGVMMLAAGTISDFIEKHPSLKMLALSFLIVVGTVLVAESFEVHVPKGYVYFAMAFSLAveALNIRLRGALARKR 239
Cdd:COG0861 146 GNIFAILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVL--ALGILASLLKRRKA 223
TerC pfam03741
Integral membrane protein TerC family; This family contains a number of integral membrane ...
14-203 4.00e-37

Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.


Pssm-ID: 461035  Cd Length: 178  Bit Score: 128.74  E-value: 4.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443    14 LTLTALEIVLGIDNIIFISILVGRLPPAQQPKARFFGLALAMGTRILLLLSITWVMRLTTDLFHLFGqgisgrdlilffg 93
Cdd:pfam03741   1 FTLVLIEIVLSVDNAFVIALIFRKLPPEQQRKALFWGIGGALVLRILLIFLGVALLELFDWLLLIGG------------- 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443    94 gLFLLFKSTMEIYHSLEGAEEEQKSGGKVHGFMGIIVQIAIID-IIFSLDSVITAVGLVQNVPVMVAAIVISVGVMMLAA 172
Cdd:pfam03741  68 -LFLLYTAIKLLRDLRKLVREEDKKLPVTSSSLWLAVIQIELAdLVFSLDSVPAAVGITDDPFIVITGNVFSILGLRFLS 146
                         170       180       190
                  ....*....|....*....|....*....|.
gi 15600443   173 GTISDFIEKHPSLKMLALSFLIVVGTVLVAE 203
Cdd:pfam03741 147 FLLAKLIERFPYLKYLAAAILGFIGVKLLLE 177
 
Name Accession Description Interval E-value
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
1-239 1.03e-56

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


Pssm-ID: 440622  Cd Length: 225  Bit Score: 180.63  E-value: 1.03e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443   1 MEWLAS-PEIWVAFLTLTALEIVLGIDNIIFISILVGRLPPAQQPKARFFGLALAMGTRILLLLSITWVMRLttDLFHLF 79
Cdd:COG0861   1 MDLLLFgPEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSF--PWILYL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443  80 GQGIsgrdLILffgglfllfKSTMEIYHSLEGAEEEQKSGGKVHGFMGIIVQIAIIDIIFSLDSVITAVGLVQNVPVMVA 159
Cdd:COG0861  79 GGLF----LLW---------TAIKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFT 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443 160 AIVISVGVMMLAAGTISDFIEKHPSLKMLALSFLIVVGTVLVAESFEVHVPKGYVYFAMAFSLAveALNIRLRGALARKR 239
Cdd:COG0861 146 GNIFAILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVL--ALGILASLLKRRKA 223
TerC pfam03741
Integral membrane protein TerC family; This family contains a number of integral membrane ...
14-203 4.00e-37

Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.


Pssm-ID: 461035  Cd Length: 178  Bit Score: 128.74  E-value: 4.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443    14 LTLTALEIVLGIDNIIFISILVGRLPPAQQPKARFFGLALAMGTRILLLLSITWVMRLTTDLFHLFGqgisgrdlilffg 93
Cdd:pfam03741   1 FTLVLIEIVLSVDNAFVIALIFRKLPPEQQRKALFWGIGGALVLRILLIFLGVALLELFDWLLLIGG------------- 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600443    94 gLFLLFKSTMEIYHSLEGAEEEQKSGGKVHGFMGIIVQIAIID-IIFSLDSVITAVGLVQNVPVMVAAIVISVGVMMLAA 172
Cdd:pfam03741  68 -LFLLYTAIKLLRDLRKLVREEDKKLPVTSSSLWLAVIQIELAdLVFSLDSVPAAVGITDDPFIVITGNVFSILGLRFLS 146
                         170       180       190
                  ....*....|....*....|....*....|.
gi 15600443   173 GTISDFIEKHPSLKMLALSFLIVVGTVLVAE 203
Cdd:pfam03741 147 FLLAKLIERFPYLKYLAAAILGFIGVKLLLE 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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