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Conserved domains on  [gi|15600468|ref|NP_253962|]
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frataxin-like protein [Pseudomonas aeruginosa PAO1]

Protein Classification

iron donor protein CyaY( domain architecture ID 10011442)

iron donor protein CyaY is involved in iron-sulfur (Fe-S) cluster assembly and may act as a regulator of Fe-S biogenesis

CATH:  3.30.920.10
Gene Ontology:  GO:0008198|GO:0016226|GO:0008199
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cyaY PRK00446
frataxin-like protein; Provisional
 4-109 3.32e-45

frataxin-like protein; Provisional


:

Pssm-ID: 234765  Cd Length: 105  Bit Score: 141.56  E-value: 3.32e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468    4 MNEARFHDLVDALQQQVEDAFDDSDLD-LDLENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEasGLWR 82
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDAdIDCERNGGVLTLTFENGSKIIINRQEPLHELWLAAKSGGFHFDYKD--GEWI 78

                         90       100
                 ....*....|....*....|....*..
gi 15600468   83 HDGSQEPLGALLNRATLEQGGEDVEFP 109
Cdd:PRK00446  79 CDRSGEEFWALLEEAATQQAGEPVSFR 105
 
Name Accession Description Interval E-value
cyaY PRK00446
frataxin-like protein; Provisional
 4-109 3.32e-45

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 141.56  E-value: 3.32e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468    4 MNEARFHDLVDALQQQVEDAFDDSDLD-LDLENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEasGLWR 82
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDAdIDCERNGGVLTLTFENGSKIIINRQEPLHELWLAAKSGGFHFDYKD--GEWI 78

                         90       100
                 ....*....|....*....|....*..
gi 15600468   83 HDGSQEPLGALLNRATLEQGGEDVEFP 109
Cdd:PRK00446  79 CDRSGEEFWALLEEAATQQAGEPVSFR 105
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 5-108 9.11e-41

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 130.41  E-value: 9.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468     5 NEARFHDLVDALQQQVEDAFDDSDLDLDLENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEasGLWRHD 84
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDDGDADIDCERQGGVLTLTFENGSQIIINKQEPLHQIWLAAKSGGFHFDYDG--GAWIDT 78

                          90       100
                  ....*....|....*....|....
gi 15600468    85 GSQEPLGALLNRATLEQGGEDVEF 108
Cdd:TIGR03421  79 RDGEELWALLARACSEQAGEPVVF 102
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 4-109 3.82e-40

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 128.76  E-value: 3.82e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468   4 MNEARFHDLVDALQQQVEDAFDDSDLDLD-LENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEasGLWR 82
Cdd:COG1965   1 MTESEFHQLADALLEAIEEALDRDDDADIdCERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAKSGGFHFDYDD--GKWI 78

                        90       100
                ....*....|....*....|....*..
gi 15600468  83 HDGSQEPLGALLNRATLEQGGEDVEFP 109
Cdd:COG1965  79 DTRSGEELFALLSRALSEQAGEPVTLA 105
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 4-108 1.04e-39

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 127.77  E-value: 1.04e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468   4 MNEARFHDLVDALQQQVEDAFDDSDLDLDL--ENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEasGLW 81
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDDDADIdvETQGGVLTLTFGNGSTIVINRQEPLRQIWLASKVGGYHFDYKN--GKW 78

                        90       100
                ....*....|....*....|....*..
gi 15600468  82 RHDGSQEPLGALLNRATLEQGGEDVEF 108
Cdd:cd00503  79 ICTRSGEELWELLEEECSAQSGEDVEF 105
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 4-106 6.25e-33

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 110.69  E-value: 6.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468     4 MNEARFHDLVDALQQQVEDAFDDSDLDLDL---ENAGGVLTVRFENGSQLILSRQAPLRQLWVAAK-SGGFHFDYDEAsG 79
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGSDadvEYSGGVLTLEFDNGGTYVINKQPPNRQIWLSSPiSGPFHFDYDDA-G 79

                          90       100
                  ....*....|....*....|....*..
gi 15600468    80 LWRHDGSQEPLGALLNRATLEQGGEDV 106
Cdd:pfam01491  80 QWIYTRDGEELFELLSRELSEQLGEPV 106
 
Name Accession Description Interval E-value
cyaY PRK00446
frataxin-like protein; Provisional
 4-109 3.32e-45

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 141.56  E-value: 3.32e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468    4 MNEARFHDLVDALQQQVEDAFDDSDLD-LDLENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEasGLWR 82
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDAdIDCERNGGVLTLTFENGSKIIINRQEPLHELWLAAKSGGFHFDYKD--GEWI 78

                         90       100
                 ....*....|....*....|....*..
gi 15600468   83 HDGSQEPLGALLNRATLEQGGEDVEFP 109
Cdd:PRK00446  79 CDRSGEEFWALLEEAATQQAGEPVSFR 105
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 5-108 9.11e-41

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 130.41  E-value: 9.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468     5 NEARFHDLVDALQQQVEDAFDDSDLDLDLENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEasGLWRHD 84
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDDGDADIDCERQGGVLTLTFENGSQIIINKQEPLHQIWLAAKSGGFHFDYDG--GAWIDT 78

                          90       100
                  ....*....|....*....|....
gi 15600468    85 GSQEPLGALLNRATLEQGGEDVEF 108
Cdd:TIGR03421  79 RDGEELWALLARACSEQAGEPVVF 102
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 4-109 3.82e-40

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 128.76  E-value: 3.82e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468   4 MNEARFHDLVDALQQQVEDAFDDSDLDLD-LENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEasGLWR 82
Cdd:COG1965   1 MTESEFHQLADALLEAIEEALDRDDDADIdCERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAKSGGFHFDYDD--GKWI 78

                        90       100
                ....*....|....*....|....*..
gi 15600468  83 HDGSQEPLGALLNRATLEQGGEDVEFP 109
Cdd:COG1965  79 DTRSGEELFALLSRALSEQAGEPVTLA 105
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 4-108 1.04e-39

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 127.77  E-value: 1.04e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468   4 MNEARFHDLVDALQQQVEDAFDDSDLDLDL--ENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEasGLW 81
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDDDADIdvETQGGVLTLTFGNGSTIVINRQEPLRQIWLASKVGGYHFDYKN--GKW 78

                        90       100
                ....*....|....*....|....*..
gi 15600468  82 RHDGSQEPLGALLNRATLEQGGEDVEF 108
Cdd:cd00503  79 ICTRSGEELWELLEEECSAQSGEDVEF 105
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 4-106 6.25e-33

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 110.69  E-value: 6.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468     4 MNEARFHDLVDALQQQVEDAFDDSDLDLDL---ENAGGVLTVRFENGSQLILSRQAPLRQLWVAAK-SGGFHFDYDEAsG 79
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGSDadvEYSGGVLTLEFDNGGTYVINKQPPNRQIWLSSPiSGPFHFDYDDA-G 79

                          90       100
                  ....*....|....*....|....*..
gi 15600468    80 LWRHDGSQEPLGALLNRATLEQGGEDV 106
Cdd:pfam01491  80 QWIYTRDGEELFELLSRELSEQLGEPV 106
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 9-96 1.21e-07

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 45.69  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600468     9 FHDLVDALQQQVEDAFDDSDLDldlENAGGVLTVRFENGSQLILSRQAPLRQLWVAA-KSGGFHFDYDEASGLWRHDGSQ 87
Cdd:TIGR03422  10 LDHLLDKLEELGESRPDLDFDV---EYSSGVLTLELPSVGTYVINKQPPNKQIWLSSpVSGPKRYDYVNGEWIYLRDGSS 86


                  ....*....
gi 15600468    88 epLGALLNR 96
Cdd:TIGR03422  87 --LTELLEE 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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