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Conserved domains on  [gi|15600517|ref|NP_254011|]
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transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12117664)

AraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Gene Ontology:  GO:0003677|GO:0006355
PubMed:  7019009|12596232

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 31-214 7.50e-33

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


:

Pssm-ID: 432679  Cd Length: 185  Bit Score: 120.83  E-value: 7.50e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517    31 GVDPARLCRGLGFTVEDLQDPTQRISYRQAVSMIQRALQALPERGLGLWVGHQNVLGTLGLLGHVLSLCRTLRDAFDIGV 110
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517   111 RYQH-SSGGIVTSSVYQQGDTFFVEVECHLPSSEVQVFAIEEFFASLLVYGRALVSPAFEPLGIELIHAAPPYAGEYLRL 189
Cdd:pfam12625  81 RYLRlLSDALELRLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYERL 160

                         170       180
                  ....*....|....*....|....*
gi 15600517   190 LGPQVRFGCLHNRMAIASHWLDMRL 214
Cdd:pfam12625 161 FGCPVRFGAPRNALVFDAADLDRPL 185
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
147-344 2.48e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 86.37  E-value: 2.48e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517 147 FAIEEFFASLLVYGRALVSPAFEPLGIELIHAAPPYAGEYLRLLGPQVRFGCLHNRMAIASHWLDMRLPNHNLPALRQAL 226
Cdd:COG2207  58 LLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELL 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517 227 ALLEQESTQVHRKLDLVQAVERAIARDLSLGSQIERISAELNMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSLLGNPG 305
Cdd:COG2207 138 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETD 217

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15600517 306 MSIERITEEVGYRDIRSFRRAFKRWTGVSPATFRSEGTS 344
Cdd:COG2207 218 LSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRA 256
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 31-214 7.50e-33

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 120.83  E-value: 7.50e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517    31 GVDPARLCRGLGFTVEDLQDPTQRISYRQAVSMIQRALQALPERGLGLWVGHQNVLGTLGLLGHVLSLCRTLRDAFDIGV 110
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517   111 RYQH-SSGGIVTSSVYQQGDTFFVEVECHLPSSEVQVFAIEEFFASLLVYGRALVSPAFEPLGIELIHAAPPYAGEYLRL 189
Cdd:pfam12625  81 RYLRlLSDALELRLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYERL 160

                         170       180
                  ....*....|....*....|....*
gi 15600517   190 LGPQVRFGCLHNRMAIASHWLDMRL 214
Cdd:pfam12625 161 FGCPVRFGAPRNALVFDAADLDRPL 185
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
147-344 2.48e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 86.37  E-value: 2.48e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517 147 FAIEEFFASLLVYGRALVSPAFEPLGIELIHAAPPYAGEYLRLLGPQVRFGCLHNRMAIASHWLDMRLPNHNLPALRQAL 226
Cdd:COG2207  58 LLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELL 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517 227 ALLEQESTQVHRKLDLVQAVERAIARDLSLGSQIERISAELNMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSLLGNPG 305
Cdd:COG2207 138 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETD 217

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15600517 306 MSIERITEEVGYRDIRSFRRAFKRWTGVSPATFRSEGTS 344
Cdd:COG2207 218 LSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRA 256
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
260-339 3.00e-19

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 81.06  E-value: 3.00e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517    260 IERISAELNMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSLLGNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATF 338
Cdd:smart00342   4 LEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEY 83


                   .
gi 15600517    339 R 339
Cdd:smart00342  84 R 84
HTH_18 pfam12833
Helix-turn-helix domain;
263-339 4.25e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 78.02  E-value: 4.25e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15600517   263 ISAELNMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSLL-GNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATFR 339
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
ftrA PRK09393
transcriptional activator FtrA; Provisional
 237-339 5.83e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 62.67  E-value: 5.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517  237 HRKLDLVQAVERAIARDLS--LGSQIERISAEL-------------NMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSL 300
Cdd:PRK09393 199 HRDGGQAQFVPRPVASRESdrLGPLIDWMRAHLaephtvaslaaraAMSPRTFLRRFEAAtGMTPAEWLLRERLARARDL 278

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 15600517  301 LGNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATFR 339
Cdd:PRK09393 279 LESSALSIDQIAERAGFGSEESLRHHFRRRAATSPAAYR 317
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 31-214 7.50e-33

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 120.83  E-value: 7.50e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517    31 GVDPARLCRGLGFTVEDLQDPTQRISYRQAVSMIQRALQALPERGLGLWVGHQNVLGTLGLLGHVLSLCRTLRDAFDIGV 110
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517   111 RYQH-SSGGIVTSSVYQQGDTFFVEVECHLPSSEVQVFAIEEFFASLLVYGRALVSPAFEPLGIELIHAAPPYAGEYLRL 189
Cdd:pfam12625  81 RYLRlLSDALELRLEEGEGGLARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHPAPADAAEYERL 160

                         170       180
                  ....*....|....*....|....*
gi 15600517   190 LGPQVRFGCLHNRMAIASHWLDMRL 214
Cdd:pfam12625 161 FGCPVRFGAPRNALVFDAADLDRPL 185
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
147-344 2.48e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 86.37  E-value: 2.48e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517 147 FAIEEFFASLLVYGRALVSPAFEPLGIELIHAAPPYAGEYLRLLGPQVRFGCLHNRMAIASHWLDMRLPNHNLPALRQAL 226
Cdd:COG2207  58 LLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELL 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517 227 ALLEQESTQVHRKLDLVQAVERAIARDLSLGSQIERISAELNMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSLLGNPG 305
Cdd:COG2207 138 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETD 217

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15600517 306 MSIERITEEVGYRDIRSFRRAFKRWTGVSPATFRSEGTS 344
Cdd:COG2207 218 LSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRA 256
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
260-339 3.00e-19

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 81.06  E-value: 3.00e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517    260 IERISAELNMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSLLGNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATF 338
Cdd:smart00342   4 LEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEY 83


                   .
gi 15600517    339 R 339
Cdd:smart00342  84 R 84
HTH_18 pfam12833
Helix-turn-helix domain;
263-339 4.25e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 78.02  E-value: 4.25e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15600517   263 ISAELNMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSLL-GNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATFR 339
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 223-339 7.34e-17

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 80.20  E-value: 7.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517 223 RQALALLEQESTQVHRKLDLVQAVERAIARDLSlgsqIERISAELNMSSRTLRRR-LAEHGLTFEALLEQVRRGRAMSLL 301
Cdd:COG4977 196 AQFSPLLVPLGHRDPRLARAQAWMEANLEEPLS----VDELARRAGMSPRTLERRfRAATGTTPARYLQRLRLERARRLL 271

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15600517 302 GNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATFR 339
Cdd:COG4977 272 ETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYR 309
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 238-342 3.80e-12

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 66.62  E-value: 3.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517 238 RKLDLVQAVERAIARDLSLGSQIERISAELNMSSRTLRRRL-AEHGLTFEALLEQVRRGRAMSLLGNpGMSIERITEEVG 316
Cdd:COG2169  81 PRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFkAHTGVTPKAYARARRLLRARQLLQT-GLSVTDAAYAAG 159

                        90       100
                ....*....|....*....|....*.
gi 15600517 317 YRDIRSFRRAFKRWTGVSPATFRSEG 342
Cdd:COG2169 160 FGSLSRFYEAFKKLLGMTPSAYRRGG 185
ftrA PRK09393
transcriptional activator FtrA; Provisional
 237-339 5.83e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 62.67  E-value: 5.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517  237 HRKLDLVQAVERAIARDLS--LGSQIERISAEL-------------NMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSL 300
Cdd:PRK09393 199 HRDGGQAQFVPRPVASRESdrLGPLIDWMRAHLaephtvaslaaraAMSPRTFLRRFEAAtGMTPAEWLLRERLARARDL 278

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 15600517  301 LGNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATFR 339
Cdd:PRK09393 279 LESSALSIDQIAERAGFGSEESLRHHFRRRAATSPAAYR 317
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 259-338 1.71e-06

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 49.22  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517  259 QIERISAELNMSSRTLRRRLAEHGLTFEALLEQVRRGRAMSLLGNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATF 338
Cdd:PRK15185 224 KLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 230-340 3.83e-06

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 47.75  E-value: 3.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517  230 EQESTQVHRKLD---LVQAVERAIARDLSLGSQIERISAELNMSSRTLRRRLAEHGLTFEALLEQVRRGRAMSLLGNPGM 306
Cdd:PRK15186 167 EPEAFALFRELSqntLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEY 246

                         90       100       110
                 ....*....|....*....|....*....|....
gi 15600517  307 SIERITEEVGYRDIRSFRRAFKRWTGVSPATFRS 340
Cdd:PRK15186 247 NITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLA 280
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
222-339 1.10e-05

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 46.51  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517  222 LRQALA--LLEQ--------ESTQVHRKLD-LVQAVERAIARDLSLGSQIERISAELNMSSRtlrrRLA-----EHGLTF 285
Cdd:PRK10572 153 YSELLAmnLLERlllrcmeaIPESLHPPMDpRVREACQYISDHLASEFDIESVAQHVCLSPS----RLAhlfrqQLGISV 228

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15600517  286 EALLEQVRRGRAMSLLGNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATFR 339
Cdd:PRK10572 229 LRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFR 282
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
249-339 2.91e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 45.05  E-value: 2.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517  249 AIARDLSLGSQIERISAELNMSSRTLRRRL-AEHGLTFEALLEQVRRGRAMSLLGNPGMSIERITEEVGYRDIRSFRRAF 327
Cdd:PRK13502 184 ALANSLECPFALDAFCQQEQCSERVLRQQFrAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVF 263

                         90
                 ....*....|..
gi 15600517  328 KRWTGVSPATFR 339
Cdd:PRK13502 264 TRETGMTPSQWR 275
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 221-340 2.91e-05

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 45.41  E-value: 2.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517  221 ALRQALALL-----EQESTQVHRKLDLVQAVERAIarDLSLGSQI---ERISAELNMSSRTLRRRLAEHGLTFEALLEQV 292
Cdd:PRK09685 172 ALLEALIALlrpalHQRESVQPRRERQFQKVVALI--DQSIQEEIlrpEWIAGELGISVRSLYRLFAEQGLVVAQYIRNR 249

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15600517  293 RRGRAMSLLGNPGMSiERITeEVGYR----DIRSFRRAFKRWTGVSPATFRS 340
Cdd:PRK09685 250 RLDRCADDLRPAADD-EKIT-SIAYKwgfsDSSHFSTAFKQRFGVSPGEYRR 299
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
260-339 3.57e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 45.09  E-value: 3.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517  260 IERISAELNMSSRTLRRRLAEH-GLTFEALLEQVRRGRAMSLLGNPGMSIERITEEVGYRDIRSFRRAFKRWTGVSPATF 338
Cdd:PRK13500 225 LDKFCDEASCSERVLRQQFRQQtGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQW 304


                 .
gi 15600517  339 R 339
Cdd:PRK13500 305 R 305
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 305-339 8.62e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 36.75  E-value: 8.62e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15600517   305 GMSIERITEEVGYrDIRSFRRAFKRWTGVSPATFR 339
Cdd:pfam00165   8 NLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYR 41
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 239-338 2.72e-03

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 39.25  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600517  239 KLDLVQAVERAIARDLSLGSQIERISAELNMSSRTLRRRLAEHGLTFEALLEQVRRGRAMSLLGNPGMSIERITEEVGYR 318
Cdd:PRK15044 190 KITTKEKVYNIIISDLTRKWSQAEVAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYD 269

                         90       100
                 ....*....|....*....|
gi 15600517  319 DIRSFRRAFKRWTGVSPATF 338
Cdd:PRK15044 270 TPSYFIAIFKRHFKITPLSF 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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