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Conserved domains on  [gi|18087767|ref|NP_291069|]
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protocadherin gamma-A8 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 11175791)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 7.30e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 147.29  E-value: 7.30e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    30 QIRYSVPEETDKGTVVGNISKDLGLEPRELAERGVRIVSRGRSQLFSLNPRGGSLVTAGRIDREELCAQSTPCLVNINIL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 18087767   110 VEE 112
Cdd:pfam08266  81 LEN 83
Cadherin_tail super family cl24520
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 811-905 1.17e-30

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


The actual alignment was detected with superfamily member pfam15974:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 117.43  E-value: 1.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   811 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 886
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 18087767   887 HVPD-YRQNVYIPGSNATLT 905
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-772 2.16e-29

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 111.85  E-value: 2.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   688 DLTLHLVVAVAVVSCVFLVFVIVLLALRLQRWQKSRQLQGSRSgLAPAPPSHFVGIDGVQAFLQTYSHEVSLTSGSQTSH 767
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 18087767   768 IIFPQ 772
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 6.82e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.82e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 246 VYRVKVLENVAPGTLLLTVRASDPDEGVNGKVTYKFRKINEKQslLFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDVG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 18087767 326 --ALLGRSKVIIMVEDVNDN 343
Cdd:cd11304  79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 1.09e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 1.09e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 456 SYTAYLPENNLRGASIFSLTAHDPDSQENAQVTYSvsedtIQGVPLSSYISINSDTGILYALQSFDFEKIQDLQLLVIAT 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS-----IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087767 536 DSGSPPLSSNVSLSLFVLDQNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 2.68e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 2.68e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 139 EVKINEIAAPGARYPLPEAVDPDVGINSLQSYQLS---PNRHFSLHLQTGddgtinpELVLERTLDREEEPTHHLVLTAS 215
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087767 216 DGGEPRRSSTALIQITVLDTNDN 238
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-664 1.08e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 1.08e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-NLVMAVQDHGQPPLSAT 657
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*..
gi 18087767 658 VTLTVAV 664
Cdd:cd11304  86 ATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-448 9.38e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 9.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 356 VLENSLPGTVIAFLNVHDQDSGKNGQVVCY---THDNLPFKLEKsidNYYRLVTWKYLDREKVSTYNITVIASDLGAPPL 432
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSivsGNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 18087767 433 STETYIALTVADTNDN 448
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 7.30e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 147.29  E-value: 7.30e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    30 QIRYSVPEETDKGTVVGNISKDLGLEPRELAERGVRIVSRGRSQLFSLNPRGGSLVTAGRIDREELCAQSTPCLVNINIL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 18087767   110 VEE 112
Cdd:pfam08266  81 LEN 83
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 811-905 1.17e-30

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 117.43  E-value: 1.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   811 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 886
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 18087767   887 HVPD-YRQNVYIPGSNATLT 905
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-772 2.16e-29

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 111.85  E-value: 2.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   688 DLTLHLVVAVAVVSCVFLVFVIVLLALRLQRWQKSRQLQGSRSgLAPAPPSHFVGIDGVQAFLQTYSHEVSLTSGSQTSH 767
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 18087767   768 IIFPQ 772
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 6.82e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.82e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 246 VYRVKVLENVAPGTLLLTVRASDPDEGVNGKVTYKFRKINEKQslLFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDVG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 18087767 326 --ALLGRSKVIIMVEDVNDN 343
Cdd:cd11304  79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 1.09e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 1.09e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 456 SYTAYLPENNLRGASIFSLTAHDPDSQENAQVTYSvsedtIQGVPLSSYISINSDTGILYALQSFDFEKIQDLQLLVIAT 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS-----IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087767 536 DSGSPPLSSNVSLSLFVLDQNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 2.68e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 2.68e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 139 EVKINEIAAPGARYPLPEAVDPDVGINSLQSYQLS---PNRHFSLHLQTGddgtinpELVLERTLDREEEPTHHLVLTAS 215
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087767 216 DGGEPRRSSTALIQITVLDTNDN 238
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 6.24e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 6.24e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    475 TAHDPDSQENAQVTYSVSEDTIQGvplssYISINSDTGILYALQSFDFEKIQDLQLLVIATDSGSPPLSSNVSLSLFVLD 554
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 18087767    555 QNDNAP 560
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-664 1.08e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 1.08e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-NLVMAVQDHGQPPLSAT 657
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*..
gi 18087767 658 VTLTVAV 664
Cdd:cd11304  86 ATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 2.28e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 2.28e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    157 AVDPDVGINSLQSYQLSPN---RHFSLHLQTGddgtinpELVLERTLDREEEPTHHLVLTASDGGEPRRSSTALIQITVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGnddGLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 18087767    234 DTNDNAP 240
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-448 9.38e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 9.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 356 VLENSLPGTVIAFLNVHDQDSGKNGQVVCY---THDNLPFKLEKsidNYYRLVTWKYLDREKVSTYNITVIASDLGAPPL 432
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSivsGNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 18087767 433 STETYIALTVADTNDN 448
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 3.21e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 3.21e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    265 RASDPDEGVNGKVTYkfRKINEKQSLLFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDVG--ALLGRSKVIIMVEDVND 342
Cdd:smart00112   1 SATDADSGENGKVTY--SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVND 78


                   ...
gi 18087767    343 NRP 345
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
247-338 2.34e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   247 YRVKVLENVAPGTLLLTVRASDPDEGVNGKVTYKFRKINEKQSllFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDVG- 325
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|....
gi 18087767   326 -ALLGRSKVIIMVE 338
Cdd:pfam00028  79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 370-450 2.57e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 2.57e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    370 NVHDQDSGKNGQVVC---YTHDNLPFKLEKSIDnyyRLVTWKYLDREKVSTYNITVIASDLGAPPLSTETYIALTVADTN 446
Cdd:smart00112   1 SATDADSGENGKVTYsilSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 18087767    447 DNPP 450
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
457-553 1.52e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   457 YTAYLPENNLRGASIFSLTAHDPDSQENAQVTYSVSEDTIQGVplssyISINSDTGILYALQSFDFEKIQDLQLLVIATD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 18087767   537 SGSPPLSSNVSLSLFVL 553
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-664 5.80e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 5.80e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18087767    592 VAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-NLVMAVQDHGQPPLSATVTLTVAV 664
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
579-664 5.25e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 5.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-NLVMAVQDHGQPPLSAT 657
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 18087767   658 VTLTVAV 664
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-129 9.48e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 9.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767  30 QIRYSVPEETDKGTVVGNIS---KDLGleprELAERGVRIVSRGRSQLFSLNPRGGSLVTAGRIDREELcaqstpCLVNI 106
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSatdPDSG----ENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTL 70

                        90       100
                ....*....|....*....|....*...
gi 18087767 107 NILVEEKGK--LFG---VEIEITDINDN 129
Cdd:cd11304  71 TVTATDGGGppLSStatVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
157-233 9.79e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 9.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   157 AVDPDVGINSLQSYQLS---PNRHFSLHLQTGDdgtinpeLVLERTLDREEEPTHHLVLTASDGGEPRRSSTALIQITVL 233
Cdd:pfam00028  20 ATDPDLGPNGRIFYSILgggPGGNFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
356-442 2.20e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 2.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   356 VLENSLPGTVIAFLNVHDQDSGKNGQVVcYthdnlpFKLEKSIDNYYR-------LVTWKYLDREKVSTYNITVIASDLG 428
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIF-Y------SILGGGPGGNFRidpdtgdISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 18087767   429 APPLSTETYIALTV 442
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-131 2.83e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 2.83e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18087767     65 RIVSRGRSQLFSLNPRGGSLVTAGRIDREElcaQSTpclVNINILVEEKGK--LFG---VEIEITDINDNNP 131
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREE---QPE---YTLTVEATDGGGppLSStatVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 7.30e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 147.29  E-value: 7.30e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    30 QIRYSVPEETDKGTVVGNISKDLGLEPRELAERGVRIVSRGRSQLFSLNPRGGSLVTAGRIDREELCAQSTPCLVNINIL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 18087767   110 VEE 112
Cdd:pfam08266  81 LEN 83
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 811-905 1.17e-30

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 117.43  E-value: 1.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   811 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 886
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 18087767   887 HVPD-YRQNVYIPGSNATLT 905
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-772 2.16e-29

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 111.85  E-value: 2.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   688 DLTLHLVVAVAVVSCVFLVFVIVLLALRLQRWQKSRQLQGSRSgLAPAPPSHFVGIDGVQAFLQTYSHEVSLTSGSQTSH 767
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 18087767   768 IIFPQ 772
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 6.82e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.82e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 246 VYRVKVLENVAPGTLLLTVRASDPDEGVNGKVTYKFRKINEKQslLFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDVG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 18087767 326 --ALLGRSKVIIMVEDVNDN 343
Cdd:cd11304  79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 1.09e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 1.09e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 456 SYTAYLPENNLRGASIFSLTAHDPDSQENAQVTYSvsedtIQGVPLSSYISINSDTGILYALQSFDFEKIQDLQLLVIAT 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS-----IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087767 536 DSGSPPLSSNVSLSLFVLDQNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 2.68e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 2.68e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 139 EVKINEIAAPGARYPLPEAVDPDVGINSLQSYQLS---PNRHFSLHLQTGddgtinpELVLERTLDREEEPTHHLVLTAS 215
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087767 216 DGGEPRRSSTALIQITVLDTNDN 238
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 6.24e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 6.24e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    475 TAHDPDSQENAQVTYSVSEDTIQGvplssYISINSDTGILYALQSFDFEKIQDLQLLVIATDSGSPPLSSNVSLSLFVLD 554
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 18087767    555 QNDNAP 560
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-664 1.08e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 1.08e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-NLVMAVQDHGQPPLSAT 657
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*..
gi 18087767 658 VTLTVAV 664
Cdd:cd11304  86 ATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 2.28e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 2.28e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    157 AVDPDVGINSLQSYQLSPN---RHFSLHLQTGddgtinpELVLERTLDREEEPTHHLVLTASDGGEPRRSSTALIQITVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGnddGLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 18087767    234 DTNDNAP 240
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-448 9.38e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 9.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767 356 VLENSLPGTVIAFLNVHDQDSGKNGQVVCY---THDNLPFKLEKsidNYYRLVTWKYLDREKVSTYNITVIASDLGAPPL 432
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSivsGNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 18087767 433 STETYIALTVADTNDN 448
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 3.21e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 3.21e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    265 RASDPDEGVNGKVTYkfRKINEKQSLLFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDVG--ALLGRSKVIIMVEDVND 342
Cdd:smart00112   1 SATDADSGENGKVTY--SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVND 78


                   ...
gi 18087767    343 NRP 345
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
247-338 2.34e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   247 YRVKVLENVAPGTLLLTVRASDPDEGVNGKVTYKFRKINEKQSllFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDVG- 325
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|....
gi 18087767   326 -ALLGRSKVIIMVE 338
Cdd:pfam00028  79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 370-450 2.57e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 2.57e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767    370 NVHDQDSGKNGQVVC---YTHDNLPFKLEKSIDnyyRLVTWKYLDREKVSTYNITVIASDLGAPPLSTETYIALTVADTN 446
Cdd:smart00112   1 SATDADSGENGKVTYsilSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 18087767    447 DNPP 450
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
457-553 1.52e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   457 YTAYLPENNLRGASIFSLTAHDPDSQENAQVTYSVSEDTIQGVplssyISINSDTGILYALQSFDFEKIQDLQLLVIATD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 18087767   537 SGSPPLSSNVSLSLFVL 553
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-664 5.80e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 5.80e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18087767    592 VAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-NLVMAVQDHGQPPLSATVTLTVAV 664
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
579-664 5.25e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 5.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-NLVMAVQDHGQPPLSAT 657
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 18087767   658 VTLTVAV 664
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-129 9.48e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 9.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767  30 QIRYSVPEETDKGTVVGNIS---KDLGleprELAERGVRIVSRGRSQLFSLNPRGGSLVTAGRIDREELcaqstpCLVNI 106
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSatdPDSG----ENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTL 70

                        90       100
                ....*....|....*....|....*...
gi 18087767 107 NILVEEKGK--LFG---VEIEITDINDN 129
Cdd:cd11304  71 TVTATDGGGppLSStatVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
157-233 9.79e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 9.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   157 AVDPDVGINSLQSYQLS---PNRHFSLHLQTGDdgtinpeLVLERTLDREEEPTHHLVLTASDGGEPRRSSTALIQITVL 233
Cdd:pfam00028  20 ATDPDLGPNGRIFYSILgggPGGNFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
356-442 2.20e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 2.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767   356 VLENSLPGTVIAFLNVHDQDSGKNGQVVcYthdnlpFKLEKSIDNYYR-------LVTWKYLDREKVSTYNITVIASDLG 428
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIF-Y------SILGGGPGGNFRidpdtgdISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 18087767   429 APPLSTETYIALTV 442
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-129 7.36e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 51.19  E-value: 7.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087767  31 IRYSVPEETDKGTVVGNISKDLGleprELAERGVRIVSRGRS---QLFSLNPRGGSLVTAGRIDREELCAQS-TPCLVNI 106
Cdd:cd00031   2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDKGVHYiSVSAASL 77

                        90       100
                ....*....|....*....|...
gi 18087767 107 NILVEEKGKLFgvEIEITDINDN 129
Cdd:cd00031  78 GANVPQTSSVF--SIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-131 2.83e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 2.83e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18087767     65 RIVSRGRSQLFSLNPRGGSLVTAGRIDREElcaQSTpclVNINILVEEKGK--LFG---VEIEITDINDNNP 131
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREE---QPE---YTLTVEATDGGGppLSStatVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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