|
Name |
Accession |
Description |
Interval |
E-value |
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-452 |
0e+00 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 909.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 1 MISVTLSQLTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDIDLPQLIV 80
Cdd:PRK10773 1 MISVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 81 KDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELG 160
Cdd:PRK10773 81 KDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 161 ANHQGEIVWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRFS 240
Cdd:PRK10773 161 ANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 241 PNAANS-DFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFP 319
Cdd:PRK10773 241 PNAANSvDFTATNIHVTSHGTEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 320 IQLAENQLLLDDSYNANVGSMTAAVQVLAEMPGYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSVGKQSHAIST 399
Cdd:PRK10773 321 IQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKLSHAISE 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 15829344 400 ASGVGEHFAEKTALITRLKSLIAEQQVITILVKGSRSAAMEEVVRALQENGTC 452
Cdd:PRK10773 401 ASGVGEHFADKTALIARLKALLAEHQVITILVKGSRSAAMEEVVRALQENGTC 453
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-451 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 577.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 2 ISVTLSQLTDILNGELQGA-DITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDIDLPQLIV 80
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGDpDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPADLPLIVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 81 KDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELG 160
Cdd:COG0770 81 DDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 161 ANHQGEIVWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRkVWRFS 240
Cdd:COG0770 161 MNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKAR-VLTFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 241 PNaANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFPI 320
Cdd:COG0770 240 LS-EDADVRAEDIELDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 321 QLAENQLLLDDSYNANVGSMTAAVQVLAEMP--GYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSVGKQSHAIS 398
Cdd:COG0770 319 EGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAIA 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 15829344 399 TASGV--GEHFAEKTALITRLKSLIAEQQVitILVKGSRSAAMEEVVRALQENGT 451
Cdd:COG0770 399 EAAGGerAEHFEDKEELLAALKALLRPGDV--VLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
29-446 |
6.56e-162 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 463.28 E-value: 6.56e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 29 TDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDID--LPQLIVKDTRLAFGELAAWVRQQVPARVVALT 106
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDngLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 107 GSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELGANHQGEIVWTVSLTRPEAALVNNLAA 186
Cdd:TIGR01143 81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 187 AHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRFSPNaaNSDFTATNIHVTSHG-TEFTLQ 265
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFE--GGDFVAKDISYSALGsTSFTLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 266 TPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFpIQLAENQLLLDDSYNANVGSMTAAVQ 345
Cdd:TIGR01143 239 APGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 346 VLAEMPGYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSVGKQSHAISTASGV-GEHFAEKTALITRLKSLiaEQ 424
Cdd:TIGR01143 318 ALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFGKqGKHFADKDELLAFLKTL--VR 395
|
410 420
....*....|....*....|..
gi 15829344 425 QVITILVKGSRSAAMEEVVRAL 446
Cdd:TIGR01143 396 KGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
19-447 |
8.61e-135 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 411.40 E-value: 8.61e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 19 GADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPL-DIDLPQLIVKDTRLAFGELAAWVRQQ 97
Cdd:PRK11929 521 NSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVaDVDLPQIVVDDTRAALGRLATAWRAR 600
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 98 VPARVVALTGSSGKTSVKEMTAAILSQ---CGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELGANHQGEIVWTVSLT 174
Cdd:PRK11929 601 FSLPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIA 680
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 175 RPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRF----SPNAANSDFTA 250
Cdd:PRK11929 681 APTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFglqpGADVYAEKIAK 760
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 251 TNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFPIQLAENQLLLD 330
Cdd:PRK11929 761 DISVGEAGGTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIID 840
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 331 DSYNANVGSMTAAVQVLAEMP-GYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSVGKqsHAISTASGVGEH--- 406
Cdd:PRK11929 841 DTYNANPDSMRAAIDVLAELPnGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGE--AARDAAAAFGAGarg 918
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 15829344 407 -FAEKTALITRLKSLIAEQQVitILVKGSRSAAMEEVVRALQ 447
Cdd:PRK11929 919 vCASVDEIIAALRGALPEGDS--VLIKGSRFMRLERVVDALS 958
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
5-449 |
4.47e-69 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 227.35 E-value: 4.47e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 5 TLSQLTDILNGELQGA---DITldAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRP----LDIDLPQ 77
Cdd:PRK14093 8 TSDAMAEAMGATRSGAlprDVT--GISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAqrdkFAADAPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 78 LIVKDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVI 157
Cdd:PRK14093 86 LVVDDVLAALRDLGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 158 ELGANHQGEIVWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVW 237
Cdd:PRK14093 166 EIGMNHAGEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAAGIA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 238 RFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVL--LPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPG 315
Cdd:PRK14093 246 RIVSFGADEKADARLLDVALHADCSAVHADILGHDVTykLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 316 RLFPIQLAENQ---LLLDDSYNANVGSMTAAVQVLAEMP----GYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVL 388
Cdd:PRK14093 326 RGVRHTLEVGGgeaTLIDESYNANPASMAAALGVLGRAPvgpqGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDLVF 405
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15829344 389 SVGKQSHAISTA--SGVGEHFAEKTAlitRLKSLIAE--QQVITILVKGSRSAAMEEVVRALQEN 449
Cdd:PRK14093 406 CCGPLMRNLWDAlsSGKRGGYAEDAA---ALESQVVAaiRAGDVIMVKGSLGSRMKTIVTALEKR 467
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
27-367 |
9.23e-51 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 178.35 E-value: 9.23e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 27 VTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDI---DLPQLIVKDTRLAFGELAAWV--RQQVPAR 101
Cdd:COG0769 2 ITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALlaaGVPVIVVPDPRAALALLAAAFygHPSQKLK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 102 VVALTGSSGKTSVKEMTAAILSQCGntlYTAGN---LNNDIG-----VPMTllrlTPE---------------YDYAVIE 158
Cdd:COG0769 82 LIGVTGTNGKTTTTYLLAQILRALG---KKTGLigtVGNGIGgelipSSLT----TPEaldlqrllaemvdagVTHVVME 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 159 -----LganHQGEI--------VWTvSLTRPeaalvnnlaaaHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWL 225
Cdd:COG0769 155 vsshaL---DQGRVdgvrfdvaVFT-NLTRD-----------HLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 226 NWQSVIGSRkVWRFSPNAaNSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKA 305
Cdd:COG0769 220 RLAAAAPAR-VITYGLKA-DADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILA 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15829344 306 GLANLKAVPGRLFPIQLAENQLLLDDsYNANVGSMTAAVQVLAEMPGYRVLVV----GD--------MAELGAE 367
Cdd:COG0769 298 ALEKLKGVPGRMERVDGGQGPTVIVD-YAHTPDALENVLEALRPHTKGRLIVVfgcgGDrdrgkrplMGEIAAR 370
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
2-448 |
1.46e-46 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 172.06 E-value: 1.46e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 2 ISVTLSQLTDILNGELQG-ADITLDAVTTDTRKLT--PGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLD----ID 74
Cdd:PRK11930 1 MSYTLESISGILGAEGLGdKDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHpeesYP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 75 LPQ-LIVKDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYD 153
Cdd:PRK11930 81 DANfLKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 154 YAVIELGANHQGEIVWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSglpENGIAIMNADNNDWLN-WQSVIG 232
Cdd:PRK11930 161 LGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLFK---DCDVIIYNGDNELISScITKSNL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 233 SRKVWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKA 312
Cdd:PRK11930 238 TLKLISWSRKDPEAPLYIPFVEKKEDHTVISYTYKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLEP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 313 VPGRLFPIQLAENQLLLDDSYNANVGSMTAAVQVL--AEMPGYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSV 390
Cdd:PRK11930 318 VAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLnrRSQSKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIGI 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 391 GKQ--SHAISTASGVGEHFAEKTALITRLKSLIAEQQviTILVKGSRSAAMEEVVRALQE 448
Cdd:PRK11930 398 GEEisSEASKFEGTEKEFFKTTEAFLKSFAFLKFRNE--LILVKGARKFEFEQITELLEQ 455
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
106-283 |
3.21e-45 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 155.93 E-value: 3.21e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 106 TGSSGKTSVKEMTAAILSQCGNTLYTAG--------NLNNDIGVPMTLLRLTP-EYDYAVIELGANHQGEiVWTVSLTRP 176
Cdd:pfam08245 2 TGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGE-GRLSGLLKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 177 EAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNN---DWLNWQSVIGSRkVWRFSPNaANSDFTATNI 253
Cdd:pfam08245 81 DIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPygaFLIAKLKKAGVR-VITYGIE-GEADLRAANI 158
|
170 180 190
....*....|....*....|....*....|.
gi 15829344 254 HVTSHGTEFTL-QTPTGSVDVLLPLPGRHNI 283
Cdd:pfam08245 159 ELSSDGTSFDLfTVPGGELEIEIPLLGRHNV 189
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
8-317 |
2.14e-36 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 139.11 E-value: 2.14e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 8 QLTDILngelqgADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDI--DLPQLIVKDTRL 85
Cdd:PRK00139 5 KLRDLL------APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAgtGVPVIIVPDLRK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 86 AFGELAAWV--RQQVPARVVALTGSSGKTSVKEMTAAILSQCGNT---LYTAGN--LNNDIGVPMTllrlTPEY------ 152
Cdd:PRK00139 79 ALALLAAAFygHPSDKLKLIGVTGTNGKTTTAYLLAQILRLLGEKtalIGTLGNgiGGELIPSGLT----TPDAldlqrl 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 153 ---------DYAVIE-----LganHQGEI--------VWTvSLTRpeaalvnnlaaAHLEGFGSLAGVAKAKGEIFSGLp 210
Cdd:PRK00139 155 laelvdagvTYAAMEvsshaL---DQGRVdglkfdvaVFT-NLSR-----------DHLDYHGTMEDYLAAKARLFSEL- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 211 eNGIAIMNADNNdwlNWQSVIGSRKVWRFSPNAAnsDFTATNIHVTSHGTEFTLQTptgsvDVLLPLPGRHNIANALAAA 290
Cdd:PRK00139 219 -GLAAVINADDE---VGRRLLALPDAYAVSMAGA--DLRATDVEYTDSGQTFTLVT-----EVESPLIGRFNVSNLLAAL 287
|
330 340
....*....|....*....|....*..
gi 15829344 291 ALSMSVGATLDAIKAGLANLKAVPGRL 317
Cdd:PRK00139 288 AALLALGVPLEDALAALAKLQGVPGRM 314
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
21-358 |
1.09e-35 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 137.45 E-value: 1.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 21 DITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDIDL---PQLIVKDTRLAFGELAAWVRQQ 97
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVapvPVIIVPDLRHALSSLAAAFYGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 98 vPAR---VVALTGSSGKTSVKEMTAAILSQCG------NTLYTAGNLNNDIGVPMTLlrLTPEY---------------D 153
Cdd:TIGR01085 81 -PSKklkVIGVTGTNGKTTTTSLIAQLLRLLGkktgliGTIGYRLGGNDLIKNPAAL--TTPEAltlqstlaemveagaQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 154 YAVIELgANH---QGEI--------VWTvSLTRpeaalvnnlaaAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNAD-- 220
Cdd:TIGR01085 158 YAVMEV-SSHalaQGRVrgvrfdaaVFT-NLSR-----------DHLDFHGTMENYFAAKASLFTELGLKRFAVINLDde 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 221 -NNDWLN------WQSVIGSRKVWRfspnaaNSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALS 293
Cdd:TIGR01085 225 yGAQFVKrlpkdiTVSAITQPADGR------AQDIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAALATL 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15829344 294 MSVG-ATLDAIKAGLANLKAVPGRLFPIQLAENQLLLDDsYNANVGSMTAAVQVLAEMPGYRVLVV 358
Cdd:TIGR01085 299 LHLGgIDLEDIVAALEKFRGVPGRMELVDGGQKFLVIVD-YAHTPDALEKALRTLRKHKDGRLIVV 363
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
16-317 |
6.34e-30 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 123.28 E-value: 6.34e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 16 ELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSR-PLDIDLP----QLIVKDTRLAFGEL 90
Cdd:PRK11929 21 WLRGCVAATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAeGEDQVAAadalVLPVADLRKALGEL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 91 AA--WVRQQVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNN-----DIGVPMTllrlTPE------------ 151
Cdd:PRK11929 101 AArwYGRPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGArldgrLIPGSLT----TPDaiilhrilarmr 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 152 ---YDYAVIElgANHQGEIVWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQ 228
Cdd:PRK11929 177 aagADAVAME--ASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 229 SVIGSRKVWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLA 308
Cdd:PRK11929 255 AALPRGLKVGYSPQNAGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALA 334
|
....*....
gi 15829344 309 NLKAVPGRL 317
Cdd:PRK11929 335 AVSPVPGRM 343
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
89-359 |
8.11e-18 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 85.08 E-value: 8.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 89 ELAAWVrqqVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNlnndIGVPMTLLRLTPEYDYAVIELgANHQGEiv 168
Cdd:TIGR01087 94 ELFLRL---VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLEL-SSFQLE-- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 169 WTVSLtRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWrfspnaansdF 248
Cdd:TIGR01087 164 TTESL-RPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIW----------F 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 249 TATNIHvtshgtEFTLQTPTGSV-----DVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFPIQLA 323
Cdd:TIGR01087 233 SVEKDA------ERGLCIRDGGLylkpnDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQK 306
|
250 260 270
....*....|....*....|....*....|....*.
gi 15829344 324 ENQLLLDDSYNANVGsmtAAVQVLAEMPGYRVLVVG 359
Cdd:TIGR01087 307 NGVHFYNDSKATNVH---ATLAALSAFDNPVILIVG 339
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
89-317 |
2.29e-16 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 80.90 E-value: 2.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 89 ELAAWVrqqVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNlnndIGVPM-TLLRLTPEYDYAVIELGAnHQGEi 167
Cdd:COG0771 97 ELAYRL---SPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGN----IGTPLlDLLLEPEPPDVYVLELSS-FQLE- 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 168 vWTVSLT---------RPEaalvnnlaaaHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWr 238
Cdd:COG0771 168 -TTPSLRpdvavilniTPD----------HLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVP- 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 239 FSPN-AANSDFTATNIHVTSHGTEftlqTPTGSVDvLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRL 317
Cdd:COG0771 236 FSLKePLEGGAGLEDGKLVDRASG----EELLPVD-DLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRL 310
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
313-403 |
1.80e-12 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 62.75 E-value: 1.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 313 VPGRLFPIQLAENQLLLDDsYNANVGSMTAAVQVLAEM-PGYRVLVVGDMAELGAEseaCHVQVGEAAKAAGiDRVLSVG 391
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLfPGRLILVFGGMGDRDAE---FHALLGRLAAALA-DVVILTG 75
|
90
....*....|..
gi 15829344 392 KQSHAISTASGV 403
Cdd:pfam02875 76 DYPRAEDPGAII 87
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
101-333 |
1.69e-11 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 65.79 E-value: 1.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 101 RVVALTGSSGKTSVKEMTAAILSQCG--NTLYTAGNL-----NNDIGVPMTLLRLTPEYDYAVIELGANhqgeiVWTVSL 173
Cdd:TIGR01082 100 HSIAVAGTHGKTTTTAMIAVILKEAGldPTVVVGGLVkeagtNARLGSGEYLVAEADESDASFLHLQPN-----VAIVTN 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 174 TRPEaalvnnlaaaHLEGFG-SLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIgSRKVWRFSPNAANSDFTATN 252
Cdd:TIGR01082 175 IEPD----------HLDTYGsSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKA-TEQVITYGGSGEDADYRAEN 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 253 IHVTSHGTEFTLQTP-TGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVpGRLFPIQLAENQLLLDD 331
Cdd:TIGR01082 244 IQQSGAEGKFSVRGKgKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGV-KRRFEILGEFGGVLLID 322
|
..
gi 15829344 332 SY 333
Cdd:TIGR01082 323 DY 324
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
18-317 |
2.13e-11 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 65.38 E-value: 2.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 18 QGADITLdavtTDTRKLtpgclfVALKGERFDAHDFADQAKAG--------GAGALLVSR--PLDIDLPQLIVKDTRLAF 87
Cdd:PRK14106 27 LGAKVIL----TDEKEE------DQLKEALEELGELGIELVLGeypeefleGVDLVVVSPgvPLDSPPVVQAHKKGIEVI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 88 GE--LAAWVrqqVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNlnndIGVPM--TLLRLTPEyDYAVIELgANH 163
Cdd:PRK14106 97 GEveLAYRF---SKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGN----IGYPLidAVEEYGED-DIIVAEV-SSF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 164 QGEivwTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNdwlNWQSVIGS--RKVWRFSP 241
Cdd:PRK14106 168 QLE---TIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDP---RTRSLAKKakARVIFFSR 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15829344 242 NA--ANSDFTATN-IHVTSHGTEftlqTPTGSVDVLlPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRL 317
Cdd:PRK14106 242 KSllEEGVFVKNGkIVISLGGKE----EEVIDIDEI-FIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRI 315
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
21-134 |
9.74e-11 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 63.52 E-value: 9.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 21 DITLDAVTTDTRKLTPGCLFVAlKGERFdAHDFADQAKAGGAGALLVSRPLDIDLPQLIVKDTRLAFGELAAWVRQ--QV 98
Cdd:PRK14022 31 GVQFDDISYDSRTADEGTLFFA-KGAYF-KHKFLQNAITQGLKLYVSEKDYEVGIPQVIVPDIKKAMSLIAMEFYDnpQH 108
|
90 100 110
....*....|....*....|....*....|....*..
gi 15829344 99 PARVVALTGSSGKTSVKEMTAAILSQCG-NTLYTAGN 134
Cdd:PRK14022 109 KLKLLAFTGTKGKTTAAYFAYHILKQLHkPAMLSTMN 145
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
27-92 |
1.08e-10 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 57.63 E-value: 1.08e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15829344 27 VTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLD-----------IDLPQLIVKDTRLAFGELAA 92
Cdd:pfam01225 5 VGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANnispdnpeleaAKVPGIPVIDRREALAELAA 81
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
188-331 |
1.37e-10 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 63.16 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 188 HLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNdwlNWQSVIG--SRKVWRFSPNAaNSDFTATNIHVTSHGTEFTLQ 265
Cdd:COG0773 184 HLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDP---GLRELLPrcGRPVITYGFSE-DADYRAENIRIDGGGSTFDVL 259
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15829344 266 TPTGSV-DVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFPIQLAENQLLLDD 331
Cdd:COG0773 260 RRGEELgEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVTVIDD 326
|
|
| LpxD |
COG1044 |
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope ... |
3-100 |
9.30e-06 |
|
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope biogenesis]; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 440666 [Multi-domain] Cd Length: 335 Bit Score: 47.32 E-value: 9.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 3 SVTLSQLTDILNGELQG-ADITLDAVTTdtrkL---TPGCL-FVAlkGERfdahdFADQAKAGGAGALLVSRPLDIDLPQ 77
Cdd:COG1044 1 SFTLAELAELLGGELVGdGDLEITGVAP----LeeaGPGDLsFLA--NPK-----YAKQLATTKASAVIVPPDFAAALPG 69
|
90 100
....*....|....*....|....*.
gi 15829344 78 ---LIVKDTRLAFGELAAWVRQQVPA 100
Cdd:COG1044 70 lalIVVDNPYLAFAKLLQLFYPPPAP 95
|
|
| lpxD |
PRK00892 |
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional |
3-93 |
4.77e-03 |
|
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional
Pssm-ID: 234858 [Multi-domain] Cd Length: 343 Bit Score: 38.97 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829344 3 SVTLSQLTDILNGELQGADitlDAVTTDTRKL---TPGCL-FVAlkGERfdahdFADQAKAGGAGALLVSRPLDIDLPQ- 77
Cdd:PRK00892 2 SLTLAELAELLGAELVGDG---DIEITGVASLeeaGPGQIsFLA--NPK-----YRKQLATTKAGAVIVSPDDAEFVPAg 71
|
90
....*....|....*....
gi 15829344 78 ---LIVKDTRLAFGELAAW 93
Cdd:PRK00892 72 nalLVVKNPYLAFARLAQL 90
|
|
| |
