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Conserved domains on  [gi|1447699269|ref|NP_308245|]
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type VI secretion system protein ImpL [Escherichia coli O157:H7 str. Sakai]

Protein Classification

type VI secretion system membrane subunit( domain architecture ID 11466348)

type VI secretion system membrane subunit such as the IcmF (intracellular multiplication protein F) family protein that exhibits ATPase activity and energizes type VI secretion; it is a conserved T6SS inner membrane protein

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
1-1143 0e+00

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 1027.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269    1 MLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALVWLTVRVMKRLQLLEKQQKQQREEAI-----DPL 75
Cdd:COG3523     12 LSLLGLLALALLIWFGGPLLAIGDYRPLESVLVRLLAIAVILLLWLLVWLVRRWRARRANRALEDALAEQAEekaaaDPS 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269   76 SVELNAQQRYLDRWLLRLQRHL----DNRRFLWQLPWYMVIGPAGSGKTTLLREG---FPSDIIYAPEGARGTEQRLYLT 148
Cdd:COG3523     92 REEIEALRERFQEALATLKKSRlgqgGGRRALYELPWYLIIGPPGAGKTTALVNSglkFPLADKFGKAAIRGVGGTRNCD 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  149 PHVGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRHREHLLQTLRSRLQDI 228
Cdd:COG3523    172 WWFTDEAVLIDTAGRYTTQDSDAEVDRAEWLGFLDLLKKHRPRQPINGVIVAISLADLLTQSPEEREQHAKALRQRLQEL 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  229 RQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLALPDLMVTQT 308
Cdd:COG3523    252 RERLGIRFPVYVLFTKADLLAGFSEFFADLDKEEREQVWGFTFPYDEKQEFDLLAEFDAEFDELLERLNERLLDRLQQER 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  309 --HTRASLFSFSRQMQGSREPLVSLLEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNNPLASWPlV 384
Cdd:COG3523    332 dpERRALIFGFPQQFAALKEALAEFLEELFEPNRyqTPPLLRGVYFTSGTQEGTPIDRVMGALARNFGLSRAALPAQS-G 410
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  385 DTAPYFTRSLFPQALLAEPNLATESRAWLMRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQAKAFMDVPP 464
Cdd:COG3523    411 SGRSYFLKDLFSKVIFPEAGLAGRNRRWERRRRWLRRAAYAAAALALLGLLGGWTWSYLNNRRLLAEVEAKVDAYRALAA 490
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  465 PQGEDD-YGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNAAPP 542
Cdd:COG3523    491 ALLVADtDLAALLPALNALRDLPAGYGYRRDDPPLsAGLGLYQGDKLGPAARAAYLRALEQLLLPRLALRLEEQLRQAPA 570
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  543 ESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQ--RDIQAQLMSHLDYALAHtdwhaerqaGDGDAISRWTP 620
Cdd:COG3523    571 DPEELYEALKAYLMLGDPEHRDADFLKAWMARDWRELLPGNtrAELRAALERHLDALLDL---------GGDPSAPPLPL 641
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  621 YDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDN--KLVVPQFLTRYGLQSYFVKQR 698
Cdd:COG3523    642 DEALVAQARAELRRVPLAQRVYARLKARALATRLPDFTLADAVGPQAALVFTRSSGKplTLGIPGLFTREGYHEVFLPAI 721
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  699 DELVELTAMDSWVLNLTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQPLQR 778
Cdd:COG3523    722 DELAEELARDDWVLGLSAEDDLSEADREQLQREVRQLYLADYIAEWRAFLGDLRLAPFTSLAQAIAALRVLSSPDSPLRR 801
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  779 ALTVLRDNTQPGVFSEKLSAKERD--------EALAEPDYQLL----------------TRLGHEFAPENITLAVQKDKE 834
Cdd:COG3523    802 LLRAVADETTLTRPSEAAAGGAAAkgllaaakARLLSARGRLGrllgadaaaaaaqvpgQPVDRHFAPLHRLVEANDGGP 881
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  835 STMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrLDQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAWHVVMVEAV 914
Cdd:COG3523    882 APLDDYLQALNELYTYLTAIANAPDPGKAALKLAK--ASGGGSDLISALKAEAGRLPEPLRRWLGSLADQAWSVVLGGAR 959
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  915 HYMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDGDNNVI-IR 990
Cdd:COG3523    960 AHLNRRWRAEVYPFCRQAIAGRYPFAPRSSRDVALADFARFFGPGGILDSFFQQNLKPFVDtsgRPWRFRPWDGQGLgLS 1039
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  991 EDIIAQLETAQKIRDIFFS-KQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrEGNESKLTL 1069
Cdd:COG3523   1040 PAVLAQFQRAAAIRDAFFAgGGAEPSVRFQIKPVSLDPGISRFTLEIDGQLLRYRHGPQRPVSVVWPGPG-GSNGARITL 1118
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1447699269 1070 IGTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGNFTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSDTL 1143
Cdd:COG3523   1119 TPLDGTSPSSLSYEGPWALFRLLDKAQLTTVSPDSFTVTFTVDGRSVTYELRADSVNNPFALPLLRGFRCPESL 1192
 
Name Accession Description Interval E-value
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
1-1143 0e+00

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 1027.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269    1 MLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALVWLTVRVMKRLQLLEKQQKQQREEAI-----DPL 75
Cdd:COG3523     12 LSLLGLLALALLIWFGGPLLAIGDYRPLESVLVRLLAIAVILLLWLLVWLVRRWRARRANRALEDALAEQAEekaaaDPS 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269   76 SVELNAQQRYLDRWLLRLQRHL----DNRRFLWQLPWYMVIGPAGSGKTTLLREG---FPSDIIYAPEGARGTEQRLYLT 148
Cdd:COG3523     92 REEIEALRERFQEALATLKKSRlgqgGGRRALYELPWYLIIGPPGAGKTTALVNSglkFPLADKFGKAAIRGVGGTRNCD 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  149 PHVGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRHREHLLQTLRSRLQDI 228
Cdd:COG3523    172 WWFTDEAVLIDTAGRYTTQDSDAEVDRAEWLGFLDLLKKHRPRQPINGVIVAISLADLLTQSPEEREQHAKALRQRLQEL 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  229 RQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLALPDLMVTQT 308
Cdd:COG3523    252 RERLGIRFPVYVLFTKADLLAGFSEFFADLDKEEREQVWGFTFPYDEKQEFDLLAEFDAEFDELLERLNERLLDRLQQER 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  309 --HTRASLFSFSRQMQGSREPLVSLLEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNNPLASWPlV 384
Cdd:COG3523    332 dpERRALIFGFPQQFAALKEALAEFLEELFEPNRyqTPPLLRGVYFTSGTQEGTPIDRVMGALARNFGLSRAALPAQS-G 410
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  385 DTAPYFTRSLFPQALLAEPNLATESRAWLMRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQAKAFMDVPP 464
Cdd:COG3523    411 SGRSYFLKDLFSKVIFPEAGLAGRNRRWERRRRWLRRAAYAAAALALLGLLGGWTWSYLNNRRLLAEVEAKVDAYRALAA 490
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  465 PQGEDD-YGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNAAPP 542
Cdd:COG3523    491 ALLVADtDLAALLPALNALRDLPAGYGYRRDDPPLsAGLGLYQGDKLGPAARAAYLRALEQLLLPRLALRLEEQLRQAPA 570
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  543 ESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQ--RDIQAQLMSHLDYALAHtdwhaerqaGDGDAISRWTP 620
Cdd:COG3523    571 DPEELYEALKAYLMLGDPEHRDADFLKAWMARDWRELLPGNtrAELRAALERHLDALLDL---------GGDPSAPPLPL 641
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  621 YDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDN--KLVVPQFLTRYGLQSYFVKQR 698
Cdd:COG3523    642 DEALVAQARAELRRVPLAQRVYARLKARALATRLPDFTLADAVGPQAALVFTRSSGKplTLGIPGLFTREGYHEVFLPAI 721
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  699 DELVELTAMDSWVLNLTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQPLQR 778
Cdd:COG3523    722 DELAEELARDDWVLGLSAEDDLSEADREQLQREVRQLYLADYIAEWRAFLGDLRLAPFTSLAQAIAALRVLSSPDSPLRR 801
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  779 ALTVLRDNTQPGVFSEKLSAKERD--------EALAEPDYQLL----------------TRLGHEFAPENITLAVQKDKE 834
Cdd:COG3523    802 LLRAVADETTLTRPSEAAAGGAAAkgllaaakARLLSARGRLGrllgadaaaaaaqvpgQPVDRHFAPLHRLVEANDGGP 881
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  835 STMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrLDQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAWHVVMVEAV 914
Cdd:COG3523    882 APLDDYLQALNELYTYLTAIANAPDPGKAALKLAK--ASGGGSDLISALKAEAGRLPEPLRRWLGSLADQAWSVVLGGAR 959
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  915 HYMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDGDNNVI-IR 990
Cdd:COG3523    960 AHLNRRWRAEVYPFCRQAIAGRYPFAPRSSRDVALADFARFFGPGGILDSFFQQNLKPFVDtsgRPWRFRPWDGQGLgLS 1039
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  991 EDIIAQLETAQKIRDIFFS-KQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrEGNESKLTL 1069
Cdd:COG3523   1040 PAVLAQFQRAAAIRDAFFAgGGAEPSVRFQIKPVSLDPGISRFTLEIDGQLLRYRHGPQRPVSVVWPGPG-GSNGARITL 1118
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1447699269 1070 IGTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGNFTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSDTL 1143
Cdd:COG3523   1119 TPLDGTSPSSLSYEGPWALFRLLDKAQLTTVSPDSFTVTFTVDGRSVTYELRADSVNNPFALPLLRGFRCPESL 1192
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
2-1141 0e+00

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 888.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269    2 LILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALVWLTVRVMK-RLQLLEKQQKQQREEAIDPLSV--- 77
Cdd:TIGR03348    2 SLLGLILLCILIWWAGPLLAVGDYKPLESVWARLLIIAVLLLVWLLWLLIRQWRaRRRNQQLLAALAAPTKLKADAAaea 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269   78 ELNAQQRYLDRWLLRLQRH-LDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FP------SDIIYAPEGARGTEQRLyl 147
Cdd:TIGR03348   82 EIRELRARFNEALALLKRSrLGGRRYLYDLPWYLVIGPPGSGKTTLLQNSglkFPlaerlgAAALRGVGGTRNCDWWF-- 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  148 tphvGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRHREHLLQTLRSRLQD 227
Cdd:TIGR03348  160 ----TDEAVLIDTAGRYTTQDSDPEEDAAAWLGFLGLLRKHRRRQPLNGVVVTVSLADLLTADPAERKAHARAIRQRLQE 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  228 IRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLALPDLMVTQ 307
Cdd:TIGR03348  236 LREQLGARFPVYLVLTKADLLAGFEEFFADLDAEEREQVWGFTFPLDEADDDNAAEEFAAEFEGLLQRLNARLLERLHQE 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  308 THT--RASLFSFSRQMQGSREPLVSLLEGLLDGENM--NVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLgnNPLASWPL 383
Cdd:TIGR03348  316 RDAarRAAIFRFPAQLAALKDRLVQFLEEAFAANRYeeAPLLRGVYFTSATQEGTPIDRLLGALARGFGL--SPGPPAAA 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  384 VDTA-PYFTRSLFPQALLAEPNLATESRAWLMRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQAKAFMDV 462
Cdd:TIGR03348  394 RGEGrSYFLKDLFKEVIFPEAGLAGLNRRAERRRRWLRRGAYAAAALAALGLLGLWSLSYLANRDYLDEVRTQLEAYRAL 473
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  463 PPPQG-EDDYGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNAA 540
Cdd:TIGR03348  474 AQAIPaAPADVLALLPALDALRDAPLGFGNYDEAPPLlARFGLYQGDKLGEAVRETYLRALQAVLLPRLMQRLEAQLQAQ 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  541 PPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHG--QRDIQAQLMSHLDYALahtdwhaerqAGDGDAISRW 618
Cdd:TIGR03348  554 EQDPEELYETLKVYLMLGDPSRRDADFVKAWFASRWEQQYPGeyQRELREALLGHLRALL----------SLDQDAVPAF 623
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  619 TPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFVK 696
Cdd:TIGR03348  624 PLDDALVEQARAELRAIPLAQRVYQRLKLQPLDAALPDLSLADALGPQADLVFERRSGKPLslGIPGLYTRAGYHDVFLP 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  697 QRDELVELTAMDSWVLN-LTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQP 775
Cdd:TIGR03348  704 QIANLVERALEDAWVLGgASGNSQLSEADRQALAREVRKLYFADYINQWDALLNDLRLKPFESLAQAAALARALASPDSP 783
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  776 LQRALTVLRDNTQPGVFSEKLS--------------AKERDEALAEPDY-----QLLTRLGHEFAPENITLAVQKDKEST 836
Cdd:TIGR03348  784 LARLLRAVARETRLTPVDGAPAdggsnaaakklsglASALGAQLLPAAPgaaalPEPGAVERHFEPLRRLLAPNGGPGAA 863
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  837 MQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrldQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAWHVVMVEAVHY 916
Cdd:TIGR03348  864 LDALLAALNELYQQLQALAASPNPGQAALKARM----SGLADALSALRQAAARLPEPLRGWLGSLAADTWKLVLQAARSH 939
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  917 MEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDGDNNVI-IRED 992
Cdd:TIGR03348  940 LNARWQSEVYSFCQQAIAGRYPFSPNSSKDVPLADFERFFGPGGLLDSFFQQNLAPFVDtsaNPWRWKGGDGGSLgISPS 1019
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  993 IIAQLETAQKIRDIFF-SKQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrEGNESKLTLIG 1071
Cdd:TIGR03348 1020 VLAQFQRAARIRDAFFrSGGGEPAVSFTLKPISLDPNIRRFVLEVDGQTLRYAHGPTRPVSLTWPGPN-DGGLARLTLKP 1098
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447699269 1072 TSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGN-FTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1141
Cdd:TIGR03348 1099 ADGGSPRTLTFSGPWALFRLLDAGRLTRTGSRDrLDLRFDVGGGAVRYELRAGSADNPFTSGLLSGFRCPG 1169
IcmF-related pfam06761
Intracellular multiplication and human macrophage-killing; This family represents a conserved ...
476-788 6.35e-72

Intracellular multiplication and human macrophage-killing; This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganization, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.


Pssm-ID: 429106 [Multi-domain]  Cd Length: 305  Bit Score: 241.86  E-value: 6.35e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  476 LPLLNPVRDATLA--YGDWGDRSRLADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA-APPESEEKLAVLR 552
Cdd:pfam06761    1 LPALDALRDLPEGllDYYQEGPPLSYRFGLYQGDKLGAAARAAYRRALRQLLLPRLAQRLEAQLRAlAGPDPEALYEALK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  553 VMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQRDIQ--AQLMSHLDYALAHtdwhAERQAGDGDAISRwtpydkpvvsAQK 630
Cdd:pfam06761   81 AYLMLGDPERRDAAFLAAWLTRDWERALPGQATGQqrEALLAHLDALLAD----PPAIPPDAALVAQ----------ARA 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  631 ELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFVKQRDELVELTAMD 708
Cdd:pfam06761  147 TLARVPLAERVYQRLKRQALASALPDFTLADAVGPDAALVFTRSSGKPLseGVPGLFTRAGYHGYFLPALDELAELLLEE 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  709 SWVLNLTRSVKYsDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQPLQRALTVLRDNTQ 788
Cdd:pfam06761  227 DWVLGDLAASAL-EADPEQLADDLRELYFTDYAAAWQAFLNDLRLVPFASLAQAIDVLRLLADPDSPLLRLLQAVADETT 305
 
Name Accession Description Interval E-value
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
1-1143 0e+00

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 1027.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269    1 MLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALVWLTVRVMKRLQLLEKQQKQQREEAI-----DPL 75
Cdd:COG3523     12 LSLLGLLALALLIWFGGPLLAIGDYRPLESVLVRLLAIAVILLLWLLVWLVRRWRARRANRALEDALAEQAEekaaaDPS 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269   76 SVELNAQQRYLDRWLLRLQRHL----DNRRFLWQLPWYMVIGPAGSGKTTLLREG---FPSDIIYAPEGARGTEQRLYLT 148
Cdd:COG3523     92 REEIEALRERFQEALATLKKSRlgqgGGRRALYELPWYLIIGPPGAGKTTALVNSglkFPLADKFGKAAIRGVGGTRNCD 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  149 PHVGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRHREHLLQTLRSRLQDI 228
Cdd:COG3523    172 WWFTDEAVLIDTAGRYTTQDSDAEVDRAEWLGFLDLLKKHRPRQPINGVIVAISLADLLTQSPEEREQHAKALRQRLQEL 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  229 RQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLALPDLMVTQT 308
Cdd:COG3523    252 RERLGIRFPVYVLFTKADLLAGFSEFFADLDKEEREQVWGFTFPYDEKQEFDLLAEFDAEFDELLERLNERLLDRLQQER 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  309 --HTRASLFSFSRQMQGSREPLVSLLEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNNPLASWPlV 384
Cdd:COG3523    332 dpERRALIFGFPQQFAALKEALAEFLEELFEPNRyqTPPLLRGVYFTSGTQEGTPIDRVMGALARNFGLSRAALPAQS-G 410
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  385 DTAPYFTRSLFPQALLAEPNLATESRAWLMRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQAKAFMDVPP 464
Cdd:COG3523    411 SGRSYFLKDLFSKVIFPEAGLAGRNRRWERRRRWLRRAAYAAAALALLGLLGGWTWSYLNNRRLLAEVEAKVDAYRALAA 490
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  465 PQGEDD-YGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNAAPP 542
Cdd:COG3523    491 ALLVADtDLAALLPALNALRDLPAGYGYRRDDPPLsAGLGLYQGDKLGPAARAAYLRALEQLLLPRLALRLEEQLRQAPA 570
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  543 ESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQ--RDIQAQLMSHLDYALAHtdwhaerqaGDGDAISRWTP 620
Cdd:COG3523    571 DPEELYEALKAYLMLGDPEHRDADFLKAWMARDWRELLPGNtrAELRAALERHLDALLDL---------GGDPSAPPLPL 641
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  621 YDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDN--KLVVPQFLTRYGLQSYFVKQR 698
Cdd:COG3523    642 DEALVAQARAELRRVPLAQRVYARLKARALATRLPDFTLADAVGPQAALVFTRSSGKplTLGIPGLFTREGYHEVFLPAI 721
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  699 DELVELTAMDSWVLNLTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQPLQR 778
Cdd:COG3523    722 DELAEELARDDWVLGLSAEDDLSEADREQLQREVRQLYLADYIAEWRAFLGDLRLAPFTSLAQAIAALRVLSSPDSPLRR 801
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  779 ALTVLRDNTQPGVFSEKLSAKERD--------EALAEPDYQLL----------------TRLGHEFAPENITLAVQKDKE 834
Cdd:COG3523    802 LLRAVADETTLTRPSEAAAGGAAAkgllaaakARLLSARGRLGrllgadaaaaaaqvpgQPVDRHFAPLHRLVEANDGGP 881
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  835 STMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrLDQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAWHVVMVEAV 914
Cdd:COG3523    882 APLDDYLQALNELYTYLTAIANAPDPGKAALKLAK--ASGGGSDLISALKAEAGRLPEPLRRWLGSLADQAWSVVLGGAR 959
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  915 HYMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDGDNNVI-IR 990
Cdd:COG3523    960 AHLNRRWRAEVYPFCRQAIAGRYPFAPRSSRDVALADFARFFGPGGILDSFFQQNLKPFVDtsgRPWRFRPWDGQGLgLS 1039
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  991 EDIIAQLETAQKIRDIFFS-KQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrEGNESKLTL 1069
Cdd:COG3523   1040 PAVLAQFQRAAAIRDAFFAgGGAEPSVRFQIKPVSLDPGISRFTLEIDGQLLRYRHGPQRPVSVVWPGPG-GSNGARITL 1118
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1447699269 1070 IGTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGNFTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSDTL 1143
Cdd:COG3523   1119 TPLDGTSPSSLSYEGPWALFRLLDKAQLTTVSPDSFTVTFTVDGRSVTYELRADSVNNPFALPLLRGFRCPESL 1192
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
2-1141 0e+00

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 888.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269    2 LILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALVWLTVRVMK-RLQLLEKQQKQQREEAIDPLSV--- 77
Cdd:TIGR03348    2 SLLGLILLCILIWWAGPLLAVGDYKPLESVWARLLIIAVLLLVWLLWLLIRQWRaRRRNQQLLAALAAPTKLKADAAaea 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269   78 ELNAQQRYLDRWLLRLQRH-LDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FP------SDIIYAPEGARGTEQRLyl 147
Cdd:TIGR03348   82 EIRELRARFNEALALLKRSrLGGRRYLYDLPWYLVIGPPGSGKTTLLQNSglkFPlaerlgAAALRGVGGTRNCDWWF-- 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  148 tphvGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRHREHLLQTLRSRLQD 227
Cdd:TIGR03348  160 ----TDEAVLIDTAGRYTTQDSDPEEDAAAWLGFLGLLRKHRRRQPLNGVVVTVSLADLLTADPAERKAHARAIRQRLQE 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  228 IRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLALPDLMVTQ 307
Cdd:TIGR03348  236 LREQLGARFPVYLVLTKADLLAGFEEFFADLDAEEREQVWGFTFPLDEADDDNAAEEFAAEFEGLLQRLNARLLERLHQE 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  308 THT--RASLFSFSRQMQGSREPLVSLLEGLLDGENM--NVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLgnNPLASWPL 383
Cdd:TIGR03348  316 RDAarRAAIFRFPAQLAALKDRLVQFLEEAFAANRYeeAPLLRGVYFTSATQEGTPIDRLLGALARGFGL--SPGPPAAA 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  384 VDTA-PYFTRSLFPQALLAEPNLATESRAWLMRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQAKAFMDV 462
Cdd:TIGR03348  394 RGEGrSYFLKDLFKEVIFPEAGLAGLNRRAERRRRWLRRGAYAAAALAALGLLGLWSLSYLANRDYLDEVRTQLEAYRAL 473
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  463 PPPQG-EDDYGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNAA 540
Cdd:TIGR03348  474 AQAIPaAPADVLALLPALDALRDAPLGFGNYDEAPPLlARFGLYQGDKLGEAVRETYLRALQAVLLPRLMQRLEAQLQAQ 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  541 PPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHG--QRDIQAQLMSHLDYALahtdwhaerqAGDGDAISRW 618
Cdd:TIGR03348  554 EQDPEELYETLKVYLMLGDPSRRDADFVKAWFASRWEQQYPGeyQRELREALLGHLRALL----------SLDQDAVPAF 623
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  619 TPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFVK 696
Cdd:TIGR03348  624 PLDDALVEQARAELRAIPLAQRVYQRLKLQPLDAALPDLSLADALGPQADLVFERRSGKPLslGIPGLYTRAGYHDVFLP 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  697 QRDELVELTAMDSWVLN-LTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQP 775
Cdd:TIGR03348  704 QIANLVERALEDAWVLGgASGNSQLSEADRQALAREVRKLYFADYINQWDALLNDLRLKPFESLAQAAALARALASPDSP 783
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  776 LQRALTVLRDNTQPGVFSEKLS--------------AKERDEALAEPDY-----QLLTRLGHEFAPENITLAVQKDKEST 836
Cdd:TIGR03348  784 LARLLRAVARETRLTPVDGAPAdggsnaaakklsglASALGAQLLPAAPgaaalPEPGAVERHFEPLRRLLAPNGGPGAA 863
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  837 MQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrldQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAWHVVMVEAVHY 916
Cdd:TIGR03348  864 LDALLAALNELYQQLQALAASPNPGQAALKARM----SGLADALSALRQAAARLPEPLRGWLGSLAADTWKLVLQAARSH 939
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  917 MEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDGDNNVI-IRED 992
Cdd:TIGR03348  940 LNARWQSEVYSFCQQAIAGRYPFSPNSSKDVPLADFERFFGPGGLLDSFFQQNLAPFVDtsaNPWRWKGGDGGSLgISPS 1019
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  993 IIAQLETAQKIRDIFF-SKQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrEGNESKLTLIG 1071
Cdd:TIGR03348 1020 VLAQFQRAARIRDAFFrSGGGEPAVSFTLKPISLDPNIRRFVLEVDGQTLRYAHGPTRPVSLTWPGPN-DGGLARLTLKP 1098
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447699269 1072 TSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGN-FTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1141
Cdd:TIGR03348 1099 ADGGSPRTLTFSGPWALFRLLDAGRLTRTGSRDrLDLRFDVGGGAVRYELRAGSADNPFTSGLLSGFRCPG 1169
IcmF-related pfam06761
Intracellular multiplication and human macrophage-killing; This family represents a conserved ...
476-788 6.35e-72

Intracellular multiplication and human macrophage-killing; This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganization, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.


Pssm-ID: 429106 [Multi-domain]  Cd Length: 305  Bit Score: 241.86  E-value: 6.35e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  476 LPLLNPVRDATLA--YGDWGDRSRLADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA-APPESEEKLAVLR 552
Cdd:pfam06761    1 LPALDALRDLPEGllDYYQEGPPLSYRFGLYQGDKLGAAARAAYRRALRQLLLPRLAQRLEAQLRAlAGPDPEALYEALK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  553 VMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQRDIQ--AQLMSHLDYALAHtdwhAERQAGDGDAISRwtpydkpvvsAQK 630
Cdd:pfam06761   81 AYLMLGDPERRDAAFLAAWLTRDWERALPGQATGQqrEALLAHLDALLAD----PPAIPPDAALVAQ----------ARA 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  631 ELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFVKQRDELVELTAMD 708
Cdd:pfam06761  147 TLARVPLAERVYQRLKRQALASALPDFTLADAVGPDAALVFTRSSGKPLseGVPGLFTRAGYHGYFLPALDELAELLLEE 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  709 SWVLNLTRSVKYsDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQPLQRALTVLRDNTQ 788
Cdd:pfam06761  227 DWVLGDLAASAL-EADPEQLADDLRELYFTDYAAAWQAFLNDLRLVPFASLAQAIDVLRLLADPDSPLLRLLQAVADETT 305
IcmF-related_N pfam14331
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular ...
174-427 1.05e-58

IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the IcmF-related domain, pfam06761.


Pssm-ID: 433873 [Multi-domain]  Cd Length: 258  Bit Score: 202.84  E-value: 1.05e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  174 HRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRHREHLLQTLRSRLQDIRQHLHCQLPVYVVLTRLDLLQGFAA 253
Cdd:pfam14331    3 DAAEWLGFLDLLKKHRPRQPINGVLVTVSLADLLSASEEEREAHARALRARLQELRETLGVRFPVYVVLTKADLLAGFDE 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  254 LFQSLNRQDRDAILGVTFTRRAHENDDWRtELNAFWQTWVDRMNLALPDLMVTQ--THTRASLFSFSRQMQGSREPLVSL 331
Cdd:pfam14331   83 FFADLDREEREQVWGFTFPYDADDEPDAV-LFDQEFDELLERLNARLLDRLQEErdAERRAAIFAFPRQFAALKPRLREF 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269  332 LEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNNPLASWPlVDTAPYFTRSLFPQALLAEPNLATES 409
Cdd:pfam14331  162 LEELFAPNRyqEAPLLRGVYFTSATQEGTPIDRLAGALARRFGLEAAALPATS-GAGRSYFLHDLFRDVIFPEAGLAGPN 240
                          250
                   ....*....|....*...
gi 1447699269  410 RAWLMRSRRRLTVFSATG 427
Cdd:pfam14331  241 RRWERRRRLLRRAGYAAA 258
IcmF_C pfam06744
Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region ...
1018-1124 1.97e-26

Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganization that results in increased adherence to epithelial cells leading to an increased conjugation frequency. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane. The exact function of this domain is not clear.


Pssm-ID: 429094 [Multi-domain]  Cd Length: 106  Bit Score: 104.72  E-value: 1.97e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699269 1018 FAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNmREGNESKLTLIGTSGNAPRSISFSGPWAQFRLFGAGQL 1097
Cdd:pfam06744    1 FELRPLPLDPGVTRFVLEIDGQTLRYRHGPSQWTPFSWPGP-RGSPGARLTLTDDDGGTVSTLSYEGPWALFRLLDKAQV 79
                           90       100
                   ....*....|....*....|....*..
gi 1447699269 1098 TGVQDGNFTVRFSVDGGAMTYRVHTDT 1124
Cdd:pfam06744   80 TRTDSDRFRLTFDVDGRKARYELRADS 106
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
68-124 9.63e-03

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 39.68  E-value: 9.63e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1447699269   68 REEAIDP--------LSVELNAqqrYLdrWLLrlqrhLDNRRFLwqlpwyMVIGPAGSGKTTLLR 124
Cdd:COG0630    260 REVPLTPidliewgtLSPELAA---YL--WLL-----LENGKSV------LVAGGTASGKTTLLN 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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