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Conserved domains on  [gi|15829826|ref|NP_308599|]
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allantoin transporter [Escherichia coli O157:H7 str. Sakai]

Protein Classification

NCS1 family nucleobase:cation symporter-1( domain architecture ID 10013788)

NCS1 family nucleobase:cation symporter-1 is an essential component in salvage pathways for nucleobases and related metabolites such as allantoin, uracil, thiamine, and nicotinamide riboside; similar to Escherichia coli putative allantoin permease

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK11375 PRK11375
putative allantoin permease;
1-463 0e+00

putative allantoin permease;


:

Pssm-ID: 183106  Cd Length: 484  Bit Score: 829.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    1 MEHQRKLFQQRGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLN 80
Cdd:PRK11375   1 MEHQRKLFQQRGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   81 GAAGSKYGVPFAMILRASYGVRGALFPGLLRGGIAAIMWFGLQCYAGSLACLILIGKIWPGFLTLGGDFTLLGLSLPGLI 160
Cdd:PRK11375  81 GAAGSKYGVPFAMILRASYGVRGALFPGLLRGGIAAIMWFGLQCYAGSLALLILIGKIWPGFLTLGGDFTLLGLSLPGLI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  161 TFLLFWLVNVGIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVGLGPIFDYIPSGIQKAENSGFLFLVVINAVVAVW 240
Cdd:PRK11375 161 TFLIFWLVNVGIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVGIGPIFDYIPSGIQKAENSGFLFLVVINAVVAVW 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  241 AAPAVSASDFTQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMT 320
Cdd:PRK11375 241 AAPAVSASDFTQNAHSFRAQALGQTLGLVVAYILFAVASVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMT 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  321 TISTNATGNIIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMR 400
Cdd:PRK11375 321 TISTNATGNIIPAGYQIAALAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMR 400
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15829826  401 GQINLDELYTAPGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVGVIVAFA 463
Cdd:PRK11375 401 GQINLDELYTAPGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIPFMEPLSRVSWFVGVIVAFV 463
 
Name Accession Description Interval E-value
PRK11375 PRK11375
putative allantoin permease;
1-463 0e+00

putative allantoin permease;


Pssm-ID: 183106  Cd Length: 484  Bit Score: 829.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    1 MEHQRKLFQQRGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLN 80
Cdd:PRK11375   1 MEHQRKLFQQRGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   81 GAAGSKYGVPFAMILRASYGVRGALFPGLLRGGIAAIMWFGLQCYAGSLACLILIGKIWPGFLTLGGDFTLLGLSLPGLI 160
Cdd:PRK11375  81 GAAGSKYGVPFAMILRASYGVRGALFPGLLRGGIAAIMWFGLQCYAGSLALLILIGKIWPGFLTLGGDFTLLGLSLPGLI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  161 TFLLFWLVNVGIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVGLGPIFDYIPSGIQKAENSGFLFLVVINAVVAVW 240
Cdd:PRK11375 161 TFLIFWLVNVGIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVGIGPIFDYIPSGIQKAENSGFLFLVVINAVVAVW 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  241 AAPAVSASDFTQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMT 320
Cdd:PRK11375 241 AAPAVSASDFTQNAHSFRAQALGQTLGLVVAYILFAVASVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMT 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  321 TISTNATGNIIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMR 400
Cdd:PRK11375 321 TISTNATGNIIPAGYQIAALAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMR 400
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15829826  401 GQINLDELYTAPGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVGVIVAFA 463
Cdd:PRK11375 401 GQINLDELYTAPGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIPFMEPLSRVSWFVGVIVAFV 463
FUI1 COG1953
Cytosine/uracil/thiamine/allantoin permease [Nucleotide transport and metabolism, Coenzyme ...
11-463 6.60e-165

Cytosine/uracil/thiamine/allantoin permease [Nucleotide transport and metabolism, Coenzyme transport and metabolism];


Pssm-ID: 441556  Cd Length: 483  Bit Score: 473.91  E-value: 6.60e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  11 RGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVP 90
Cdd:COG1953  19 RLYNEDLAPTPAEKRTWGWYNIFALWMGMVHSVPGYTLAAGLFALGLSWWQALLALLLGNLIVLVPMNLNGHAGTKYGIP 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  91 FAMILRASYGVRGALFPGLLRGGIAaIMWFGLQCYAGSLACLILIGKIWPGFLTLGGDFTLLGLSLPGLITFLLFWLVNV 170
Cdd:COG1953  99 FPVLARASFGVRGANIPALLRGLIA-IGWFGIQTYLASQALDALLLKLFPGLASLGGAHSFLGLSALGWISFLLFWALQL 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 171 GIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVG-LGPIFDYiPSGIQKAENSGFLFLVVINAVVAVWAAPAVSASD 249
Cdd:COG1953 178 LIFWRGMEAIRKFEDWAGPLVYVVMLALAIWALSKAGgFGPILSL-PSKFLSGGAFWAVFFPALTLMVAYWATLALNFPD 256
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 250 FTQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATGN 329
Cdd:COG1953 257 FTRFAKSQRAQVRGQFLGLPVNMLLFSFIGVVTTSATVVVFGEAIWDPVELVARIDSPFAVVLALLTFLIATVGINIVAN 336
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 330 IIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDELY 409
Cdd:COG1953 337 FVSPAYDFSNLFPKKISFRRGGLITAVIGLLITPWNLYNSPEGIFYFLGGLGALLGPVFGILIADYYLVRRQRLDVDDLY 416
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 15829826 410 TAPGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVGVIVAFA 463
Cdd:COG1953 417 SEDDGRYWYRNGWNPRAVIALVVGAVISLAGALVPALAPLYDYSWFVGAALGGV 470
SLC-NCS1sbd_YbbW-like cd11485
uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; ...
11-463 7.03e-164

uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. This subfamily includes the putative allantoin transporter Escherichia coli YbbW (also known as GlxB2). NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).


Pssm-ID: 271378  Cd Length: 456  Bit Score: 470.13  E-value: 7.03e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  11 RGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVP 90
Cdd:cd11485   3 RLYNEDLAPVPPEQRTWTTWNYAALWIGMVHNIPTYMLASGLIALGMSWWQALLTVVLGNLIVLIPMVLNGHAGTKYGIP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  91 FAMILRASYGVRGALFPGLLRGgIAAIMWFGLQCYAGSLACLILIGK-IWPGFLTLGGDFTLLGlslpglitFLLFWLVN 169
Cdd:cd11485  83 FPVLARASFGVRGANIPALLRA-IVACGWFGIQTWIGGQAIYAILGVlIWPGWLGIGFGQLFCF--------LLFPWALN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 170 VGIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLV-GLGPIFDYIPSGIQKAENSGFLFLVVINAVVAVWAAPAVSAS 248
Cdd:cd11485 154 VWIIYKGMESIRKLEAWAAPLLILLSLALLIWAISKAgGFGPILSQPSAFGPKGGNFWKVFFPALTAMIGFWATLALNIP 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 249 DFTQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATG 328
Cdd:cd11485 234 DFTRFAKSQRAQVLGQAIGLPITMALFAFVGVAVTSATVVIFGEAIWDPVDLLSRFDNPAVVIIALLAIILATLSTNVAA 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 329 NIIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDS-IYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDE 407
Cdd:cd11485 314 NLVSPAYDFANLFPKKISFRRGGLITAVLGLLIMPWKLLENADGyIFTWLGGYGALLGPIAGIMIADYWLVRRTRLDLDD 393
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15829826 408 LYTAPGDYkYYDNGFNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVGVIVAFA 463
Cdd:cd11485 394 LYRRGGRY-WYSNGWNWRALIALAVGVLPALPGFLIPALKWLYDYAWFVGFAVAGL 448
ncs1 TIGR00800
NCS1 nucleoside transporter family; The Nucleobase:Cation Symporter-1 (NCS1) Family (TC 2.A.39) ...
14-457 1.31e-122

NCS1 nucleoside transporter family; The Nucleobase:Cation Symporter-1 (NCS1) Family (TC 2.A.39) The NCS1 family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have been shown to function in uptake by substrate:H+ symport mechanism. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273275  Cd Length: 442  Bit Score: 364.37  E-value: 1.31e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    14 SEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAM 93
Cdd:TIGR00800   1 NEDLQPVKEEERTWSFLNYFSLWLGAAFNIATWAIGALGLPLGLSWWQSVIAIILGNLLGGIFVALNSRAGAKYGLPFPV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    94 ILRASYGVRGALFPGLLRGgIAAIMWFGLQCYAGSLACLILIGKIWPGFLTLGGdftllGLSLPGLITFLLFWLVNVGIG 173
Cdd:TIGR00800  81 LSRASFGIYGSLLPSLLRI-VMAIGWYGVQAWVGGLCVALMLDSIFPGYLHLGN-----GMTTLELICFIIFWALVLVFL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   174 FGGGKVLNKFTAILNPCIYIVFGGMAIWAISLV-GLGPIFDYIpsGIQKAENSGFLFLVVINAVVAVWAAPAVSASDFTQ 252
Cdd:TIGR00800 155 FFFGYKIRHLFEWLAVVPPFAAFGMLIWALSKAhGKGPLGELT--GTLHGSTGAWAFLYALSLVIGSFATWATNAPDFTR 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   253 NAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAV------LVILMTTISTNA 326
Cdd:TIGR00800 233 FGKSKKTAIWGQFLALPGGFTLTCFFGILGAAAAYAAYGEPYWSPLDILARFLGLTYAVGARavfgfgFCFVVAQLSTNI 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   327 TGNIIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLD 406
Cdd:TIGR00800 313 SANSYSAGLDIAALLPKYIKIKRGSLICAIIALLICPWNLYNSSSKFTTFLSSIGGFLSPIAGVMIADYFVVRRGYLHLT 392
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15829826   407 ELYTAPgDYKYYDNGfNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVG 457
Cdd:TIGR00800 393 TLYSDS-KGEYYPGG-IKGVNWRAVVAVICGLAPCLPGFVGEVGRDIGVLG 441
Transp_cyt_pur pfam02133
Permease for cytosine/purines, uracil, thiamine, allantoin;
19-457 6.95e-121

Permease for cytosine/purines, uracil, thiamine, allantoin;


Pssm-ID: 251109  Cd Length: 439  Bit Score: 360.16  E-value: 6.95e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    19 PKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAMILRAS 98
Cdd:pfam02133   1 PVPEEERTWSTRNLFSFWLGANFNINTWVIGALGVALGLNWWQSVLAIIAGNLIGAIFVALLGRAGAKYGLPFPILSRAS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    99 YGVRGALFPGLLRGGIAaIMWFGLQCYAGSLACLILIGKIWPGFLTLGgdfTLLGLSLPGLITFLLFWLVNVGIGFGGGK 178
Cdd:pfam02133  81 FGIRGSLLPSLLRAVIA-CGWFGIQAWIGSEALLLMLGKIFGHWLWIG---AIPGTGLTELVTFFIFWLVHLYIVWLGVS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   179 VLNKFTAILNPCIYIVFGGMAIWAISLVGLGPIFDYIPSGIQkaensGFLFLVVINAVVAVWAAPAVSASDFTQNAHSFR 258
Cdd:pfam02133 157 AIRVFFVIAAPLIPVAAFGFLIWAAVKAGGGPVFDQPVSPGK-----SELFLSAVAGCAAGWATLIANAPDFTRYAPTAR 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   259 EQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATGNIIPAGYQIA 338
Cdd:pfam02133 232 SSSKIQLVAVPGGFTLFALIGILGAAAAYAAYGAPAWDPLDILARFDPTAGVFLPAILVALAQLGTNISANLYSAGSDLA 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   339 AIAPTKLTYKNGVLIASIISLLICPWKLMENQDS-IYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDELYTA-PGDYK 416
Cdd:pfam02133 312 ALLPKKINRKRGSLIAAIIALVICPWKLLGNSAFmFTTFLSLLSGFLSPVAGVIIADYFVVRRGYLHVAHLYTRrRGSAY 391
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 15829826   417 YYDNGFNLTAFSVTLVAVILSLGG-------KFIPLMEPLSRVSWFVG 457
Cdd:pfam02133 392 WYRGGVNWRAFAAYIVGIAAGLPGfsgsvgiKVPPGAMLGFDLSYLVG 439
 
Name Accession Description Interval E-value
PRK11375 PRK11375
putative allantoin permease;
1-463 0e+00

putative allantoin permease;


Pssm-ID: 183106  Cd Length: 484  Bit Score: 829.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    1 MEHQRKLFQQRGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLN 80
Cdd:PRK11375   1 MEHQRKLFQQRGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   81 GAAGSKYGVPFAMILRASYGVRGALFPGLLRGGIAAIMWFGLQCYAGSLACLILIGKIWPGFLTLGGDFTLLGLSLPGLI 160
Cdd:PRK11375  81 GAAGSKYGVPFAMILRASYGVRGALFPGLLRGGIAAIMWFGLQCYAGSLALLILIGKIWPGFLTLGGDFTLLGLSLPGLI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  161 TFLLFWLVNVGIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVGLGPIFDYIPSGIQKAENSGFLFLVVINAVVAVW 240
Cdd:PRK11375 161 TFLIFWLVNVGIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVGIGPIFDYIPSGIQKAENSGFLFLVVINAVVAVW 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  241 AAPAVSASDFTQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMT 320
Cdd:PRK11375 241 AAPAVSASDFTQNAHSFRAQALGQTLGLVVAYILFAVASVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMT 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  321 TISTNATGNIIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMR 400
Cdd:PRK11375 321 TISTNATGNIIPAGYQIAALAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMR 400
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15829826  401 GQINLDELYTAPGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVGVIVAFA 463
Cdd:PRK11375 401 GQINLDELYTAPGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIPFMEPLSRVSWFVGVIVAFV 463
FUI1 COG1953
Cytosine/uracil/thiamine/allantoin permease [Nucleotide transport and metabolism, Coenzyme ...
11-463 6.60e-165

Cytosine/uracil/thiamine/allantoin permease [Nucleotide transport and metabolism, Coenzyme transport and metabolism];


Pssm-ID: 441556  Cd Length: 483  Bit Score: 473.91  E-value: 6.60e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  11 RGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVP 90
Cdd:COG1953  19 RLYNEDLAPTPAEKRTWGWYNIFALWMGMVHSVPGYTLAAGLFALGLSWWQALLALLLGNLIVLVPMNLNGHAGTKYGIP 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  91 FAMILRASYGVRGALFPGLLRGGIAaIMWFGLQCYAGSLACLILIGKIWPGFLTLGGDFTLLGLSLPGLITFLLFWLVNV 170
Cdd:COG1953  99 FPVLARASFGVRGANIPALLRGLIA-IGWFGIQTYLASQALDALLLKLFPGLASLGGAHSFLGLSALGWISFLLFWALQL 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 171 GIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVG-LGPIFDYiPSGIQKAENSGFLFLVVINAVVAVWAAPAVSASD 249
Cdd:COG1953 178 LIFWRGMEAIRKFEDWAGPLVYVVMLALAIWALSKAGgFGPILSL-PSKFLSGGAFWAVFFPALTLMVAYWATLALNFPD 256
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 250 FTQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATGN 329
Cdd:COG1953 257 FTRFAKSQRAQVRGQFLGLPVNMLLFSFIGVVTTSATVVVFGEAIWDPVELVARIDSPFAVVLALLTFLIATVGINIVAN 336
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 330 IIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDELY 409
Cdd:COG1953 337 FVSPAYDFSNLFPKKISFRRGGLITAVIGLLITPWNLYNSPEGIFYFLGGLGALLGPVFGILIADYYLVRRQRLDVDDLY 416
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 15829826 410 TAPGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVGVIVAFA 463
Cdd:COG1953 417 SEDDGRYWYRNGWNPRAVIALVVGAVISLAGALVPALAPLYDYSWFVGAALGGV 470
SLC-NCS1sbd_YbbW-like cd11485
uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; ...
11-463 7.03e-164

uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. This subfamily includes the putative allantoin transporter Escherichia coli YbbW (also known as GlxB2). NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).


Pssm-ID: 271378  Cd Length: 456  Bit Score: 470.13  E-value: 7.03e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  11 RGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVP 90
Cdd:cd11485   3 RLYNEDLAPVPPEQRTWTTWNYAALWIGMVHNIPTYMLASGLIALGMSWWQALLTVVLGNLIVLIPMVLNGHAGTKYGIP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  91 FAMILRASYGVRGALFPGLLRGgIAAIMWFGLQCYAGSLACLILIGK-IWPGFLTLGGDFTLLGlslpglitFLLFWLVN 169
Cdd:cd11485  83 FPVLARASFGVRGANIPALLRA-IVACGWFGIQTWIGGQAIYAILGVlIWPGWLGIGFGQLFCF--------LLFPWALN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 170 VGIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLV-GLGPIFDYIPSGIQKAENSGFLFLVVINAVVAVWAAPAVSAS 248
Cdd:cd11485 154 VWIIYKGMESIRKLEAWAAPLLILLSLALLIWAISKAgGFGPILSQPSAFGPKGGNFWKVFFPALTAMIGFWATLALNIP 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 249 DFTQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATG 328
Cdd:cd11485 234 DFTRFAKSQRAQVLGQAIGLPITMALFAFVGVAVTSATVVIFGEAIWDPVDLLSRFDNPAVVIIALLAIILATLSTNVAA 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 329 NIIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDS-IYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDE 407
Cdd:cd11485 314 NLVSPAYDFANLFPKKISFRRGGLITAVLGLLIMPWKLLENADGyIFTWLGGYGALLGPIAGIMIADYWLVRRTRLDLDD 393
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15829826 408 LYTAPGDYkYYDNGFNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVGVIVAFA 463
Cdd:cd11485 394 LYRRGGRY-WYSNGWNWRALIALAVGVLPALPGFLIPALKWLYDYAWFVGFAVAGL 448
ncs1 TIGR00800
NCS1 nucleoside transporter family; The Nucleobase:Cation Symporter-1 (NCS1) Family (TC 2.A.39) ...
14-457 1.31e-122

NCS1 nucleoside transporter family; The Nucleobase:Cation Symporter-1 (NCS1) Family (TC 2.A.39) The NCS1 family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have been shown to function in uptake by substrate:H+ symport mechanism. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273275  Cd Length: 442  Bit Score: 364.37  E-value: 1.31e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    14 SEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAM 93
Cdd:TIGR00800   1 NEDLQPVKEEERTWSFLNYFSLWLGAAFNIATWAIGALGLPLGLSWWQSVIAIILGNLLGGIFVALNSRAGAKYGLPFPV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    94 ILRASYGVRGALFPGLLRGgIAAIMWFGLQCYAGSLACLILIGKIWPGFLTLGGdftllGLSLPGLITFLLFWLVNVGIG 173
Cdd:TIGR00800  81 LSRASFGIYGSLLPSLLRI-VMAIGWYGVQAWVGGLCVALMLDSIFPGYLHLGN-----GMTTLELICFIIFWALVLVFL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   174 FGGGKVLNKFTAILNPCIYIVFGGMAIWAISLV-GLGPIFDYIpsGIQKAENSGFLFLVVINAVVAVWAAPAVSASDFTQ 252
Cdd:TIGR00800 155 FFFGYKIRHLFEWLAVVPPFAAFGMLIWALSKAhGKGPLGELT--GTLHGSTGAWAFLYALSLVIGSFATWATNAPDFTR 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   253 NAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAV------LVILMTTISTNA 326
Cdd:TIGR00800 233 FGKSKKTAIWGQFLALPGGFTLTCFFGILGAAAAYAAYGEPYWSPLDILARFLGLTYAVGARavfgfgFCFVVAQLSTNI 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   327 TGNIIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLD 406
Cdd:TIGR00800 313 SANSYSAGLDIAALLPKYIKIKRGSLICAIIALLICPWNLYNSSSKFTTFLSSIGGFLSPIAGVMIADYFVVRRGYLHLT 392
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15829826   407 ELYTAPgDYKYYDNGfNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVG 457
Cdd:TIGR00800 393 TLYSDS-KGEYYPGG-IKGVNWRAVVAVICGLAPCLPGFVGEVGRDIGVLG 441
Transp_cyt_pur pfam02133
Permease for cytosine/purines, uracil, thiamine, allantoin;
19-457 6.95e-121

Permease for cytosine/purines, uracil, thiamine, allantoin;


Pssm-ID: 251109  Cd Length: 439  Bit Score: 360.16  E-value: 6.95e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    19 PKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAMILRAS 98
Cdd:pfam02133   1 PVPEEERTWSTRNLFSFWLGANFNINTWVIGALGVALGLNWWQSVLAIIAGNLIGAIFVALLGRAGAKYGLPFPILSRAS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826    99 YGVRGALFPGLLRGGIAaIMWFGLQCYAGSLACLILIGKIWPGFLTLGgdfTLLGLSLPGLITFLLFWLVNVGIGFGGGK 178
Cdd:pfam02133  81 FGIRGSLLPSLLRAVIA-CGWFGIQAWIGSEALLLMLGKIFGHWLWIG---AIPGTGLTELVTFFIFWLVHLYIVWLGVS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   179 VLNKFTAILNPCIYIVFGGMAIWAISLVGLGPIFDYIPSGIQkaensGFLFLVVINAVVAVWAAPAVSASDFTQNAHSFR 258
Cdd:pfam02133 157 AIRVFFVIAAPLIPVAAFGFLIWAAVKAGGGPVFDQPVSPGK-----SELFLSAVAGCAAGWATLIANAPDFTRYAPTAR 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   259 EQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATGNIIPAGYQIA 338
Cdd:pfam02133 232 SSSKIQLVAVPGGFTLFALIGILGAAAAYAAYGAPAWDPLDILARFDPTAGVFLPAILVALAQLGTNISANLYSAGSDLA 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826   339 AIAPTKLTYKNGVLIASIISLLICPWKLMENQDS-IYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDELYTA-PGDYK 416
Cdd:pfam02133 312 ALLPKKINRKRGSLIAAIIALVICPWKLLGNSAFmFTTFLSLLSGFLSPVAGVIIADYFVVRRGYLHVAHLYTRrRGSAY 391
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 15829826   417 YYDNGFNLTAFSVTLVAVILSLGG-------KFIPLMEPLSRVSWFVG 457
Cdd:pfam02133 392 WYRGGVNWRAFAAYIVGIAAGLPGfsgsvgiKVPPGAMLGFDLSYLVG 439
SLC-NCS1sbd cd10323
nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; NCS1s are essential ...
26-463 5.25e-106

nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. This family includes Microbacterium liquefaciens Mhp1, a transporter that mediates the uptake of indolyl methyl- and benzyl-hydantoins as part of a metabolic salvage pathway for their conversion to amino acids. It also includes various Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), vitamin B6 transporter Tpn1, nicotinamide riboside transporter 1 (Nrt1p, also called Thi71p), Dal4p (allantoin permease), Fui1p (uridine permease), and Fur4p (uracil permease). Mhp1 has 12 transmembrane (TM) helices (an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12; TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and SLC6 neurotransmitter transporters.


Pssm-ID: 271358  Cd Length: 414  Bit Score: 321.15  E-value: 5.25e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  26 TWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTfSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAMILRASYGVRGAL 105
Cdd:cd10323   1 TMGPLSYLAMWLGDCVSIGTFTLGGSLVGLGLLW-QVILAILIGCLIIGIFLVLNGRIGYKYGIPFAVQLRASFGIKGSH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 106 FPGLLRGgIAAIMWFGLQCYAGSLACLILIGKIWPgfltlggdFTLLglslpgLITFLLFWLVNVGIGFGGGKVLNKFTA 185
Cdd:cd10323  80 IPSLLRG-VPAIVWFGFQTWLGALALNEISGLLFG--------FDNI------VLCFIIFGLLQIVLSFFGIKAIKWLEN 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 186 ILNPCIYIVFGGMAIWAISLVG--LGPIFDYipsgiqKAENSGFLFLVVINAVVAVWAAPAVSASDFTQNAH---SFREQ 260
Cdd:cd10323 145 IAAPAIIAALVYMFYLLVNKAGdeIGENLWY------KAGTWGLPFLVAIMAFVGNWAALALNAPDYSRELKpgkRNRNV 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 261 ALGQTLGLVVAYILFAVAGVCIIAGASIhygadtWNVLDIVQRWDS-LFASFFAVLVILMTTISTNATGNIIPAGYQIAA 339
Cdd:cd10323 219 GLAQFVALVPAFLFMGLIGAMSTAATGI------WNPVDVIQGVVSnGFLLVLTLVFIVLAQWSTNIAANIVPPAYVFMN 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 340 IAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDELYTAPGDYKYYd 419
Cdd:cd10323 293 LFPRKITYKTGVVIAGILGLCICPWLLVNDLSALTTFLGIYSAFLGPIFGIMIADYYVLRRRRVNVDDLYDANGQYKYF- 371
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 15829826 420 NGFNLTAFSVTLVAVILSLggkfiplmePLSRVSWFVGVIVAFA 463
Cdd:cd10323 372 KGVNWAAIIAMAVGAAAAL---------LLVDLSWFVGLIVAGL 406
SLC-NCS1sbd_u1 cd11555
uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding ...
11-463 1.74e-97

uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).


Pssm-ID: 271404  Cd Length: 461  Bit Score: 300.63  E-value: 1.74e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  11 RGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVP 90
Cdd:cd11555   3 RLYNEDLAPTKARGRTWGWYSIFAFWMSDVHSLGGYTFAASLFALGLNGWQVFLALILGILIVYLLCNLVGKPSQKTGVP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  91 FAMILRASYGVRGALFPGLLRGGIAaIMWFGLQCYAGSLACLILIGKIWPGFLTLGgDFTLLGLSLPGLITFLLFWLVNV 170
Cdd:cd11555  83 FPVMARASFGVFGANIPALIRGVIA-IFWYGIQTYLASTAVALLLLKLFPGLASLT-QHSFLGLSTLGWISFLILWALQL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 171 GIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVGlGPIFDYIPSGIQKAENSGFLFLVVINAVVAVWAAPAVSASDF 250
Cdd:cd11555 161 LVFWRGMEAIRKFIDWAGPAVYVVMIALAIWILSRAG-GNISFTLGTVFLTGGEMVAAFLAAVALVVAYFSGPMLNFGDF 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 251 TQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATGNI 330
Cdd:cd11555 240 SRYAKSEKAVRRGNFWGLPVNFLLFSLITVVTTAGTLPVFGEAITDPVEIVARIDNLLATVLAALTFLIATVGINIVANF 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 331 IPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDELYT 410
Cdd:cd11555 320 VSPAYDLSNLAPKKISFRRGGLIAAVLAVVITPWNLYNSPVVIHYFLDGLGAFLGPLFGILIVDYYLVRKGRVDVPDLYS 399
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 15829826 411 A-PGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIPLMEPLSRVSWFVGVIVAFA 463
Cdd:cd11555 400 DsPKGAYWYRNGWNPKAVAALVPAAAISVLTVLVPALAALAGFSWFIGAALGGV 453
SLC-NCS1sbd_NRT1-like cd11482
nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; This fungal ...
13-463 2.25e-72

nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; This fungal NCS1 subfamily includes various Saccharomyces cerevisiae transporters: nicotinamide riboside transporter 1 (Nrt1p, also called Thi71p), Dal4p (allantoin permease), Fui1p (uridine permease), Fur4p (uracil permease), and Thi7p (thiamine transporter). NCS1s are essential components of salvage pathways for nucleobases and related metabolites. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters, and solute carrier 6 family neurotransmitter transporters.


Pssm-ID: 271375  Cd Length: 480  Bit Score: 236.26  E-value: 2.25e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  13 YSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFA 92
Cdd:cd11482   2 SNRDLDPVPPERRTWGWWSFFAYWISDSFNISTWQTGSSLLALGLSWWQAIGAVIIGNILIAIFVVLNGRPGAKYHIGFP 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  93 MILRASYGVRGALFPGLLRgGIAAIMWFGLQCYAGSLACLILIGKIWPGFLTLGGDFTL-LGLSLPGLITFLLFWLVNVG 171
Cdd:cd11482  82 VASRASFGIYGSYFPVIIR-VVLAIVWFGVQAWTGGQCVTVMLRAIFPSFLNIPNTLPAsAGITTAQLIGFFLFWLIQLP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 172 IGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLV-GLGPIFDYIPSGiqKAENSGFLFLVVINAVVAVWAAPAVSASDF 250
Cdd:cd11482 161 FLFIPPEKLRHLFTVKAVIVPIAALGLLIWALAKAgGAGPLVSQPSSL--SGSALGWAWLSGINSIIGGFSTLIVNQPDF 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 251 TQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWD-------SLFASFFAVLVILMTTIS 323
Cdd:cd11482 239 TRYAKKPPDAVWGQLISIPLSGTLVPLLGILTTSASKVLYGEAYWNPLDLLDAWLdhdysagARAAAFFAALGFALAQLG 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 324 TNATGNIIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSiylFLDIIGG---MLGPVIGVMMAHYFVVMR 400
Cdd:cd11482 319 TNISANSISAGNDLTGLFPKYINIRRGAIICAILGWAIVPWKLLNSASS---FLTFLSSysvFLAPIAGIMIADYYIVRR 395
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15829826 401 GQINLDELYTAPGDYKY-YDNGFNLTAFSVTLVAVILSLGGkFIPLMEPLSRVS----------WFVGVIVAFA 463
Cdd:cd11482 396 GKLKLPDLYTASPHGIYwYTKGVNWRAFVAWLVGVAPNLPG-LANSVNPPVSVPggavrlyylgYLLGFLISFV 468
SLC-NCS1sbd_Mhp1-like cd11483
nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; This NCS1 ...
14-438 2.26e-46

nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; This NCS1 subfamily includes Microbacterium liquefaciens Mhp1, and various uncharacterized NCS1s. Mhp1 mediates the uptake of indolyl methyl- and benzyl-hydantoins as part of a metabolic salvage pathway for their conversion to amino acids. Mhp1 has 12 transmembrane (TM) helices (an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12; TMs numbered to conform to the Solute carrier 6 (SLC6) family Aquifex aeolicus LeuT). NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their other known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and SLC6 neurotransmitter transporters.


Pssm-ID: 271376  Cd Length: 451  Bit Score: 166.46  E-value: 2.26e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  14 SEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFF--ILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPF 91
Cdd:cd11483   7 NPELLPTRYAERSMSLFDYAILWAGMTINVVAFSLGAQYYngGDGLSPWTVIVVILIGYGIVTILTFLTGDIGTKYGVPF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  92 AMILRASYGVRGALFPGLLRGgIAAIMWFGLQCYAGSLAcLILIGKIWPGFLTLggdfTLLglslpgLITFLLFWLVNVg 171
Cdd:cd11483  87 AVYARAPFGYKGSLIAGLLRA-IPSLYWFGFQTWVGALA-LNEIMRILFGFSNL----TLM------IIIFAAIQVVNT- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 172 igFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVGLGpifdyIPSGIQKAENSGFLFLVVINAVVAVWAAPAVSASDFT 251
Cdd:cd11483 154 --MYGLKAMAKFDWIAIPVLAIMFVAIVYLMLDKYNVS-----LPEIMSTGGEGGYSFAFAIMGIAGGWITMALNGSDLV 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 252 QNAHSF------------REQALGQTLGLVVAYILFAVAGVciIAGASIHYgadtWNVLDIVQRW--DSLFASFFAVLVI 317
Cdd:cd11483 227 RQIKRDpnyenegffkrnKRAIIGQWLGLMPVGIIFMLIGM--ASGILTGE----WDLNIVITELfgGSIPVLILFFIFI 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 318 LMTTISTNATGNIIPAGYQIAAIAPtKLTYKNGVLIASIISLLICPWKLmENQDSIYLFLDIIGGMLGPVIGVMMAHYFV 397
Cdd:cd11483 301 LFAQWSTNTAANLLPPAYVLLNIFP-KLKFKMSVIISGVIGLLMMPWKF-QGVGFLVTFQNLISSMLGPIIGIMLADYFL 378
                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 15829826 398 VMRGQINLDELYTAPGDYKYYdNGFNLTAFSVTLVAVILSL 438
Cdd:cd11483 379 IRKCKLNVHDLYRAGGQYQYT-NGFNWSAVAALVVAFAVSL 418
CodB COG1457
Purine-cytosine permease or related protein [Nucleotide transport and metabolism];
22-463 4.42e-29

Purine-cytosine permease or related protein [Nucleotide transport and metabolism];


Pssm-ID: 441066 [Multi-domain]  Cd Length: 448  Bit Score: 118.82  E-value: 4.42e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  22 QSQRTWKTFNYFTLWMGSVHNVPnYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAMILRASYGV 101
Cdd:COG1457  24 ESERHGSPRSLFWVWFGANVALA-TFVIGALLGLGLGFWQALLAILLGNLIGFLLGALIAYIGARTGLPTMLLSRAAFGY 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 102 RGALFPGLLrGGIAAIMWFGLQCYAGSLACLILIGkiwpgfltlggdftllGLSLPGLITFLLFWLVNVGIGFGGGKVLN 181
Cdd:COG1457 103 RGSTLPSLL-NALTTIGWFAVEAAIAAQALAALLG----------------GLGIPLVLAYLIVGLLVILLAIFGYRAIS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 182 KFTAILNPCIYIVFGGMAIWAISLVGLGPIFDYIPSGiqkaenSGFLFLVVINAVVAVWAAPAVSASDFT---QNAHSFR 258
Cdd:COG1457 166 RLQRWAVPLLLVLFVLLVVLALSHPGLSALLAYPPGS------SPLSFGAAVSVVAGLFISWAPYAADYSrylPRKTSGR 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 259 EQALGQTLGLVVAYILFAVAGVCIIAGASihygaDTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATgNIIPAGYQIA 338
Cdd:COG1457 240 AVFWATFLGFVLGGVLLMLLGALLAAAAP-----GAADPVGALGALLPTGLGVPALLVVILSQWTINVL-NLYSASLALS 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 339 AIAPtKLTYKNGVLIASIISLLICPWKLMenqDSIYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDELYTAPGDYKyy 418
Cdd:COG1457 314 NLFP-RLGRVVATLVVGVIGTLLALLGFL---DAFENFLLLLGVVLPPWGGIMLADYFLVRRGRYDPDALFDRRGRYG-- 387
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 15829826 419 dnGFNLTAFSVTLVAVILSLGGKFIP--LMEPLSRVSWFVGVIVAFA 463
Cdd:COG1457 388 --GVNWVGLIAWLLGSVVGILFVNTPglFGPALADLSWLVALVVAAV 432
SLC-NCS1sbd_CobB-like cd11484
nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 ...
23-463 6.45e-18

nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).


Pssm-ID: 271377 [Multi-domain]  Cd Length: 406  Bit Score: 85.36  E-value: 6.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826  23 SQRTWKTFNYFTLWMGSVHNVPNYvMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAMILRASYGVR 102
Cdd:cd11484   3 EERRKSFLSMFSVWLGANFFLASM-VTGALLGVGLSLSQAILAVLLGNLIGGAYMALLGYIGARTGLPQMLLSRASFGEK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 103 GALFPGLLRgGIAAIMWFGLQCYAGSLACLILigkiwpgfltLGGDFTLLGLSLpgLITFLLFWLVNVGIgfgggKVLNK 182
Cdd:cd11484  82 GSYLPSLLL-GITQIGWFGVGTAMFAIALSKL----------LGINGSLWLLIL--IAGVLMTLTAIFGY-----KALHK 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 183 FTAILNPCIYIVFGGMAIWAISLVGLGPIFDYIPSGiqkaensGFLFLVVINAVVAVWAAPAVSASDFTQNAHSFREQAL 262
Cdd:cd11484 144 LEKIAVPLIIALFVYSVVLALRDYGVGGLAALTATG-------PLSFLVAVSLVAGSFISGATYTADYSRYAKSSKKAFW 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 263 GQTLGLVVAYILFAVAGVCIIAGAsihygadtwNVLDIVQRWDSLFASFFAVLVILMTTISTNaTGNIIPAGYQIAAIAP 342
Cdd:cd11484 217 ATFLGFFVGNSLMMILGALLAAAT---------GTADISEVMIAQGLGIPAILVLVLNIWTTN-DNNLYSSGLSLSNITK 286
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829826 343 tKLTYKNGVLIASIISLLICPWKLMENQDSiylFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDELYTAPgdykyyDNGF 422
Cdd:cd11484 287 -IFRRKVLTLVAGIVGTLLAALGIYNHFLN---FLLLLGYALPPWGGVMLADYFVVRRGRYDIDALADPQ------YGGV 356
                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 15829826 423 NLTAFSVTLVAVIlsLGGKFIPLMEPLSRVSWFVGVIVAFA 463
Cdd:cd11484 357 NWAALIAWAVGVA--VGIPFPYGLLGGGGIAPINGLLVAAV 395
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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