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Conserved domains on  [gi|15830268|ref|NP_309041|]
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nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. Sakai]

Protein Classification

nicotinate phosphoribosyltransferase( domain architecture ID 10012319)

nicotinate phosphoribosyltransferase (NAPRTase) catalyzes the first and rate limiting step of the NAD salvage pathway, the formation of nicotinic acid mononucleotide (NAMN) and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid

CATH:  3.20.140.10
EC:  6.3.4.21
Gene Ontology:  GO:0004516|GO:0009435
PubMed:  19149599|19109034
SCOP:  4002556|4002550

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK05321 PRK05321
nicotinate phosphoribosyltransferase; Provisional
1-400 0e+00

nicotinate phosphoribosyltransferase; Provisional


:

Pssm-ID: 235406 [Multi-domain]  Cd Length: 400  Bit Score: 724.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268    1 MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDD-LLGIYADAIREQVQAMQHLRLQDDEYQWLSALPF 79
Cdd:PRK05321   1 HTWKADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   80 FKADYLNWLREFRFNPEQVTVSNDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDfsa 159
Cdd:PRK05321  81 FKPDFLDWLRLFRLNPYEVTVSIDDGQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIEL--- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  160 LTAGLDMSRFHLMDFGTRRRFSREVQETIVKRLQQE--SWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQ 237
Cdd:PRK05321 158 LKALPDLSGFKIADFGTRRRFSFEWQEEVVEALKEGlpGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQ 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  238 RAALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLEIDPQSKTLVFSDNLD 317
Cdd:PRK05321 238 YAALEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLD 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  318 LRKAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPHIK 397
Cdd:PRK05321 318 FDKALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVFGLPLVV 397

                 ...
gi 15830268  398 KAS 400
Cdd:PRK05321 398 KAS 400
 
Name Accession Description Interval E-value
PRK05321 PRK05321
nicotinate phosphoribosyltransferase; Provisional
1-400 0e+00

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 235406 [Multi-domain]  Cd Length: 400  Bit Score: 724.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268    1 MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDD-LLGIYADAIREQVQAMQHLRLQDDEYQWLSALPF 79
Cdd:PRK05321   1 HTWKADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   80 FKADYLNWLREFRFNPEQVTVSNDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDfsa 159
Cdd:PRK05321  81 FKPDFLDWLRLFRLNPYEVTVSIDDGQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIEL--- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  160 LTAGLDMSRFHLMDFGTRRRFSREVQETIVKRLQQE--SWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQ 237
Cdd:PRK05321 158 LKALPDLSGFKIADFGTRRRFSFEWQEEVVEALKEGlpGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQ 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  238 RAALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLEIDPQSKTLVFSDNLD 317
Cdd:PRK05321 238 YAALEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLD 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  318 LRKAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPHIK 397
Cdd:PRK05321 318 FDKALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVFGLPLVV 397

                 ...
gi 15830268  398 KAS 400
Cdd:PRK05321 398 KAS 400
NAPRTase TIGR01514
nicotinate phosphoribosyltransferase; This model represents nicotinate ...
8-394 0e+00

nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 130578 [Multi-domain]  Cd Length: 394  Bit Score: 632.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268     8 VLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDL-LGIYADAIREQVQAMQHLRLQDDEYQWLSA-LPFFKADYL 85
Cdd:TIGR01514   1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQLfLKEAAEALREEISALGNLRFTDDEIEYLKQeLPYLKSDYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268    86 NWLREFRFNP-EQVTVS-NDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDFSALTAG 163
Cdd:TIGR01514  81 DYLRNFRFHPeEQVEVGiDDKGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   164 LDMS--RFHLMDFGTRRRFSREVQETIVKRLQQE--SWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPdLANSQRA 239
Cdd:TIGR01514 161 ETMFenGFRFSEFGTRRRFSLEVQDLVTQGLKQAapSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   240 ALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLEIDPQSKTLVFSDNLDLR 319
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15830268   320 KAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLP 394
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELFDTP 394
PncB_like cd01401
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ...
10-376 0e+00

Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.


Pssm-ID: 238695 [Multi-domain]  Cd Length: 377  Bit Score: 611.17  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  10 HSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGD-DLLGIYADAIREQVQAMQHLRLQDDEYQWLS-ALPFFKADYLNW 87
Cdd:cd01401   1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPeDFLEEAAEALREQIDHLANLRFSEEELAYLRrSLPFLKPDYLDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  88 LREFRFNPEQVTVSND--NGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDFSALTAGLD 165
Cdd:cd01401  81 LELFRLNPEEVVVRLDtgKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 166 MSRFHLMDFGTRRRFSREVQETIVKRLQQE--SWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQRAALAA 243
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKQAapGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 244 WLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLEIDPQSKTLVFSDNLDLRKAVE 323
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15830268 324 LYRHFSSRVQLSFGIGTRLTCDIPQ---VKPLNIVIKLVECNGKPVAKLSDSPGKT 376
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGNkekSTPLNIVIKLVECNGRPVAKISDSPGKN 376
NAPRTase pfam04095
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ...
169-395 3.48e-116

Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.


Pssm-ID: 397974 [Multi-domain]  Cd Length: 235  Bit Score: 338.20  E-value: 3.48e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   169 FHLMDFGTRRRFSREVQETIVKRlqQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQRAALAAWLEEY 248
Cdd:pfam04095   1 FKLHDFGTRRRSSLESQEIVGLA--HLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHAEY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   249 PDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLE-IDPQSKTLVFSDNLDLRKAVELYRH 327
Cdd:pfam04095  79 RGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTLnIDGYTKRLIFSDGLDVEKIIELLEY 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15830268   328 F-SSRVQLSFGIGTRLTCDIPQ--------VKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPH 395
Cdd:pfam04095 159 FkGKGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFDNGE 235
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
10-376 4.76e-33

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 128.73  E-value: 4.76e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  10 HSLLDTDAYKL-HMQQAVFHHYYDVHVAAEFRCR-----GDDLL--GIyadairEQV-QAMQHLRLQDDEYQWLSALPFF 80
Cdd:COG1488   3 NLALLTDLYKLtMAQAYLPEGTANRRAVFELFFRrlpfgRGYVVfaGL------QRFlKYLENLRFTEEDIAYLRSLGVF 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  81 KADYLNWLREFRFN------PEqvtvsndnGKL------DIRLSGPWREVILWEVPLLAVISEmvhryrspQADVAqald 148
Cdd:COG1488  77 DEDFLDYLADFRFPgdiravPE--------GTVvfpgepLLTVEGTLPEAQLLETLLLNILNY--------PTLIA---- 136
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 149 TLESKLVdfsaLTAGldmsRFHLMDFGTRRRFSREVQETIVkRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHqq 228
Cdd:COG1488 137 TKAARIV----QAAG----GRPLHDFGLRRAHGLEAAVAAA-RAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAH-- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 229 ispdlaNSQRAALAAWLEEYPDQLgIALTDciTMD--AFLRDfGVEFASRYQ------GLRHDSGDPVEWGEKAIAHYEK 300
Cdd:COG1488 206 ------DDELEAFRAFAEAYPDGT-TLLVD--TYDtlSGVPN-AIELAKELLarggllGIRLDSGDLAYLSKQARELLDE 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 301 LeiDPQSKTLVFSDNLDLRKAVELYRH-FSSRVqlsFGIGTRLTCDIPQvkP-LNIVIKLVECNGK----PVAKLSDSPG 374
Cdd:COG1488 276 A--GLPDVRIIASDDLDEYRIAALLEQgAPIDV---FGVGTRLVTSSDR--PtLGFVYKLVAVEGDgewrPVIKLSETPG 348

                ..
gi 15830268 375 KT 376
Cdd:COG1488 349 KK 350
 
Name Accession Description Interval E-value
PRK05321 PRK05321
nicotinate phosphoribosyltransferase; Provisional
1-400 0e+00

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 235406 [Multi-domain]  Cd Length: 400  Bit Score: 724.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268    1 MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDD-LLGIYADAIREQVQAMQHLRLQDDEYQWLSALPF 79
Cdd:PRK05321   1 HTWKADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   80 FKADYLNWLREFRFNPEQVTVSNDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDfsa 159
Cdd:PRK05321  81 FKPDFLDWLRLFRLNPYEVTVSIDDGQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIEL--- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  160 LTAGLDMSRFHLMDFGTRRRFSREVQETIVKRLQQE--SWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQ 237
Cdd:PRK05321 158 LKALPDLSGFKIADFGTRRRFSFEWQEEVVEALKEGlpGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQ 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  238 RAALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLEIDPQSKTLVFSDNLD 317
Cdd:PRK05321 238 YAALEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLD 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  318 LRKAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPHIK 397
Cdd:PRK05321 318 FDKALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVFGLPLVV 397

                 ...
gi 15830268  398 KAS 400
Cdd:PRK05321 398 KAS 400
NAPRTase TIGR01514
nicotinate phosphoribosyltransferase; This model represents nicotinate ...
8-394 0e+00

nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 130578 [Multi-domain]  Cd Length: 394  Bit Score: 632.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268     8 VLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDL-LGIYADAIREQVQAMQHLRLQDDEYQWLSA-LPFFKADYL 85
Cdd:TIGR01514   1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQLfLKEAAEALREEISALGNLRFTDDEIEYLKQeLPYLKSDYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268    86 NWLREFRFNP-EQVTVS-NDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDFSALTAG 163
Cdd:TIGR01514  81 DYLRNFRFHPeEQVEVGiDDKGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   164 LDMS--RFHLMDFGTRRRFSREVQETIVKRLQQE--SWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPdLANSQRA 239
Cdd:TIGR01514 161 ETMFenGFRFSEFGTRRRFSLEVQDLVTQGLKQAapSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   240 ALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLEIDPQSKTLVFSDNLDLR 319
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15830268   320 KAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLP 394
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELFDTP 394
PncB_like cd01401
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ...
10-376 0e+00

Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.


Pssm-ID: 238695 [Multi-domain]  Cd Length: 377  Bit Score: 611.17  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  10 HSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGD-DLLGIYADAIREQVQAMQHLRLQDDEYQWLS-ALPFFKADYLNW 87
Cdd:cd01401   1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPeDFLEEAAEALREQIDHLANLRFSEEELAYLRrSLPFLKPDYLDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  88 LREFRFNPEQVTVSND--NGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDFSALTAGLD 165
Cdd:cd01401  81 LELFRLNPEEVVVRLDtgKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 166 MSRFHLMDFGTRRRFSREVQETIVKRLQQE--SWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQRAALAA 243
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKQAapGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 244 WLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLEIDPQSKTLVFSDNLDLRKAVE 323
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15830268 324 LYRHFSSRVQLSFGIGTRLTCDIPQ---VKPLNIVIKLVECNGKPVAKLSDSPGKT 376
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGNkekSTPLNIVIKLVECNGRPVAKISDSPGKN 376
NAPRTase pfam04095
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ...
169-395 3.48e-116

Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.


Pssm-ID: 397974 [Multi-domain]  Cd Length: 235  Bit Score: 338.20  E-value: 3.48e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   169 FHLMDFGTRRRFSREVQETIVKRlqQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQRAALAAWLEEY 248
Cdd:pfam04095   1 FKLHDFGTRRRSSLESQEIVGLA--HLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHAEY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   249 PDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLE-IDPQSKTLVFSDNLDLRKAVELYRH 327
Cdd:pfam04095  79 RGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTLnIDGYTKRLIFSDGLDVEKIIELLEY 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15830268   328 F-SSRVQLSFGIGTRLTCDIPQ--------VKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPH 395
Cdd:pfam04095 159 FkGKGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFDNGE 235
NAPRTase_PncB cd01567
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ...
12-357 1.14e-103

Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238801 [Multi-domain]  Cd Length: 343  Bit Score: 310.36  E-value: 1.14e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  12 LLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDD--LLGIYADAIREQVQAMQHLRLQDDEYQWLS----------ALPF 79
Cdd:cd01567   1 LLDTDLYKLTMMQAYLYPYPNTRVVFEFTFRSNPfgGDYIVFAGLEEVLKLLENLRFTEEEIEYLKkllifgefflYLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  80 FKADYLNWLREFRFNPEQVTVsndngkLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKlvdfsa 159
Cdd:cd01567  81 LGKLPLEIYALPEGTVVFPKE------PLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLLETK------ 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 160 ltAGLDMSRFHLMDFGTRRRFSrevQETIVKRLQQE--SWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQqispDLANSQ 237
Cdd:cd01567 149 --DNLEELGFKLHDFGTRRRHS---PEAALSGGRAAliGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFG----ALEEAA 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 238 RAALAAWLEEYPDQLGIALTDCITMD-AFLRDFGVEFAS----RYQGLRHDSGDPVEWGEKAIAHYEKLEIDPQSKTLVF 312
Cdd:cd01567 220 FEAFARWLPQFGGGLGIALIDTYDTDnGFLNALKLAKALgaggGLLGVRLDSGDPVELIKKVRKHLDELGIDLNKKKIII 299
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 15830268 313 SDNLDLRKAVELYRHFSSRVQLSFGIGTRLTCDIPQvKPLNIVIK 357
Cdd:cd01567 300 SGDLDTEEAIELLLEQGASPNDAFGVGTSLTNDLGR-PPLGFVYK 343
PRTase_typeII cd00516
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ...
16-357 5.17e-49

Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.


Pssm-ID: 238286 [Multi-domain]  Cd Length: 281  Bit Score: 167.42  E-value: 5.17e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  16 DAYKLHMQQAvfHHYYDVHVAAEFRCRGDDllGIYADAIREQVQAMQHLRLqddeyqwlsalpffkADYLNWLREFRFNP 95
Cdd:cd00516   1 DLYKLTMIQA--YPPPDTRATAEFTAREDP--YGVLAGLEEALELLELLRF---------------PGPLVILAVPEGTV 61
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  96 EQVtvsndnGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDtlesklvdfsaltagldmSRFHLMDFG 175
Cdd:cd00516  62 VEP------GEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAKG------------------ANTKVHDFG 117
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 176 TRRRFSrevqETIVKRLQQE--SWFVGTSNYDLARRLSLTPMGTQAHEWFQAHqqispdLANSQRAALAAWLEeypdQLG 253
Cdd:cd00516 118 TRKTTP----GLRLLEKYAVliGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF------GELAAVKALRRWLP----ELF 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 254 IALTDCITMDaFLRDFGVEFASRYQGLRHDSG-----DPVEWGEKAIAHYEklEIDPQSKTLVFSDNLDLrKAVELYRHF 328
Cdd:cd00516 184 IALIDVEVDT-LEEALEAAKAGGADGIRLDSGspeelDPAVLILKARAHLD--GKGLPRVKIEASGGLDE-ENIRAYAET 259
                       330       340
                ....*....|....*....|....*....
gi 15830268 329 SsrvQLSFGIGTRLTcdipQVKPLNIVIK 357
Cdd:cd00516 260 G---VDVFGVGTLLH----SAPPLDIVLK 281
NAPRTase_N pfam17767
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ...
13-130 1.14e-44

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.


Pssm-ID: 465494 [Multi-domain]  Cd Length: 125  Bit Score: 150.74  E-value: 1.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268    13 LDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDLLG--IYADAIREQVQAMQHLRLQDDEYQWLS-ALPFFKADYLNWLR 89
Cdd:pfam17767   1 LDTDLYKLTMAQAYFKNGPDVQVVFEFFNRTNPFGGlyAVFAGLEEQIEFLENLRFTEEEIEYLRrSLPYFKPDFLDYLR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 15830268    90 EFRFNPEQVTVSND----NGKLDIRLSGPWREVILWEVPLLAVIS 130
Cdd:pfam17767  81 NFRFDPSIVAVPEGevvfPGEPLLRIEGPWLETILLETPLLAIVN 125
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
10-376 4.76e-33

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 128.73  E-value: 4.76e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  10 HSLLDTDAYKL-HMQQAVFHHYYDVHVAAEFRCR-----GDDLL--GIyadairEQV-QAMQHLRLQDDEYQWLSALPFF 80
Cdd:COG1488   3 NLALLTDLYKLtMAQAYLPEGTANRRAVFELFFRrlpfgRGYVVfaGL------QRFlKYLENLRFTEEDIAYLRSLGVF 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  81 KADYLNWLREFRFN------PEqvtvsndnGKL------DIRLSGPWREVILWEVPLLAVISEmvhryrspQADVAqald 148
Cdd:COG1488  77 DEDFLDYLADFRFPgdiravPE--------GTVvfpgepLLTVEGTLPEAQLLETLLLNILNY--------PTLIA---- 136
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 149 TLESKLVdfsaLTAGldmsRFHLMDFGTRRRFSREVQETIVkRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHqq 228
Cdd:COG1488 137 TKAARIV----QAAG----GRPLHDFGLRRAHGLEAAVAAA-RAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAH-- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 229 ispdlaNSQRAALAAWLEEYPDQLgIALTDciTMD--AFLRDfGVEFASRYQ------GLRHDSGDPVEWGEKAIAHYEK 300
Cdd:COG1488 206 ------DDELEAFRAFAEAYPDGT-TLLVD--TYDtlSGVPN-AIELAKELLarggllGIRLDSGDLAYLSKQARELLDE 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 301 LeiDPQSKTLVFSDNLDLRKAVELYRH-FSSRVqlsFGIGTRLTCDIPQvkP-LNIVIKLVECNGK----PVAKLSDSPG 374
Cdd:COG1488 276 A--GLPDVRIIASDDLDEYRIAALLEQgAPIDV---FGVGTRLVTSSDR--PtLGFVYKLVAVEGDgewrPVIKLSETPG 348

                ..
gi 15830268 375 KT 376
Cdd:COG1488 349 KK 350
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
13-388 1.25e-25

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 107.83  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268    13 LDTDAYKLHMQQAVFHH-------YYDVHvaaeFR----CRGddlLGIYAdAIREQVQAMQHLRLQDDEYQWLSALPFFK 81
Cdd:TIGR01513   2 LLTDLYELTMAQGYFREgkanqpaVFEVF----FRklpfGRG---YAVFA-GLEDLLEFLENFRFDAEDIEYLASLGIFD 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268    82 ADYLNWLREFRFNpeqvtvsndngkLDIRlSGPWREVILWEVPLLAVISEMVhryrspqadVAQALDTLESKLVDFSAL- 160
Cdd:TIGR01513  74 DAFLDYLREFRFS------------GTVR-ALPEGSLVFPNEPLLQVEGPLI---------EAQLLETLVLNIINFQTLi 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   161 -TAGLDMSRFH----LMDFGTRRrfsreVQET----IVKRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHqqisp 231
Cdd:TIGR01513 132 aTKAARIVLAAggkpLLEFGLRR-----AQGPdaalKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----- 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   232 dlaNSQRAALAAWLEEYPD--QLGIALTDCIT--MDAFL---RDFGVEFASRyqGLRHDSGDPVEWGEKAIAHYEKLEId 304
Cdd:TIGR01513 202 ---DNELAAFRAYAKLYPKatVLLVDTYDTLRsgLPNAIavaKELGEQGKVV--GVRIDSGDLLYLSKQARKQLDAAGL- 275
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   305 PQSKTLVfSDNLDLRKAVELyrhFSSRVQL-SFGIGTRL-TCdiPQVKPLNIVIKLVECNGKPVAKLSDSPGK-TICHDK 381
Cdd:TIGR01513 276 TQVKIVV-SNDLDENSIAAL---KAEGAPIdVYGVGTSLvTA--SDAPALGGVYKLVAYEGRPVMKLSENPEKsTLPGRK 349

                  ....*..
gi 15830268   382 AFVRALR 388
Cdd:TIGR01513 350 QVFRLYD 356
PRK12484 PRK12484
nicotinate phosphoribosyltransferase; Provisional
13-377 4.88e-17

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 237112 [Multi-domain]  Cd Length: 443  Bit Score: 82.49  E-value: 4.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   13 LDTDAYKLHMQQAVFHH------YYDVHVAAEFRCRGddllGIYADAIREQVQAMQHLRLQDDEYQWLSALPFFKADYLN 86
Cdd:PRK12484   6 LLTDLYEVTMANAYLREgmsapaTFSLFYRKLPDGRG----FLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQFSEEFLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   87 WLREFRFN------PEQVTVSNDNGKLDIrlSGPWREVILWEVPLLAVISEmvhryrspQADVAqaldtleSKLVDFSAL 160
Cdd:PRK12484  82 WLAGLRFTgdvravPEGTVVFPNEPLLEV--TAPLIEAQLVETFLLNQINH--------QSLIA-------SKAARCVLA 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  161 TAGLDmsrfhLMDFGTRRR--FSREVQetiVKRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHqqisPDlansQR 238
Cdd:PRK12484 145 AAGRP-----VVDFGARRAhgTDAACY---VARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAF----PD----EV 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  239 AALAAWLEEYPDQLgIALTDciTMDA---------FLRDFGVEFASRyqGLRHDSGDPVEWGEKAiahyeKLEID----P 305
Cdd:PRK12484 209 AAFRAFARLYPDAT-TLLVD--TYDTlrgvrnaieVAKELGNRFDPR--GVRLDSGDLAELSKAT-----RAILDaaglE 278
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15830268  306 QSKtLVFSDNLDLRKAVELYRhfsSRVQLS-FGIGTRL--TCDIPQvkpLNIVIKLVECNGKPVAKLsdSPGKTI 377
Cdd:PRK12484 279 QVK-IVASGGLDEYRIAALLA---AGAPIDgFGVGTRLgvAADAPV---LDSAYKLVAYEGRGVTKL--SSGKVT 344
PRK09243 PRK09243
nicotinate phosphoribosyltransferase; Validated
1-376 5.82e-15

nicotinate phosphoribosyltransferase; Validated


Pssm-ID: 236426 [Multi-domain]  Cd Length: 464  Bit Score: 75.96  E-value: 5.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268    1 MTQFASPVLHslldTDAYKLHM-----------QQAVFHHYydvhvaaeFR----CRGddlLGIYADAirEQV-QAMQHL 64
Cdd:PRK09243   3 MYNDDSLALL----TDLYELTMaqaylrdgihnRRAVFELF--------FRklpfGRG---YAVFAGL--ERLlEYLENL 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268   65 RLQDDEYQWLSALPFFKADYLNWLREFRFnpeqvtvsndNGKLD--------------IRLSGPWREVILWEVPLLAVI- 129
Cdd:PRK09243  66 RFTEEDIEYLRSLGIFDEDFLDYLRNFRF----------TGDVRavpegelvfpneplLRVEGPLAEAQLLETLLLNIIn 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  130 ---------SEMVHryrspqadVAQAlDTlesklvdfsaltagldmsrfhLMDFGTRRRFSRE--VqetivkrlqqesW- 197
Cdd:PRK09243 136 fqtliatkaARIVS--------AAGG-RP---------------------LLEFGSRRAQGPDaaV------------Wa 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  198 --------FVGTSNYDLARRLSLTPMGTQAHEWFQAHqqispdlaNSQRAALAAWLEEYPDqlgialtDCItmdaFLRD- 268
Cdd:PRK09243 174 araayiggFDATSNVLAGKRYGIPVSGTMAHSFVQAF--------DDEYEAFRAYAETYPD-------NTV----LLVDt 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  269 -----FGV--------EFASRYQ--GLRHDSGDPVEWGEKA-----IAHYEKLEIdpqsktlVFSDNLD--------LRK 320
Cdd:PRK09243 235 ydtlkSGVpnaikvakELGDGIElgGVRIDSGDLAYLSKKVrkmldEAGFTDTKI-------VASNDLDeytiaslkLQG 307
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15830268  321 AvelyrhfssRVQlSFGIGTRL-TC-DIPqvkPLNIVIKLVECNGK----PVAKLSDSPGKT 376
Cdd:PRK09243 308 A---------PID-GFGVGTKLvTGsDAP---ALGGVYKLVAIEGEggmiPKIKLSNSPEKV 356
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
13-359 2.48e-14

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 73.38  E-value: 2.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  13 LDTDAYKLHMQQAVFHH-------YYDVHvaaeFR----CRGddlLGIYAdAIREQVQAMQHLRLQDDEYQWLSALPFFK 81
Cdd:cd01570   2 LLTDLYQLTMAQAYWKEgkhnkpaVFELF----FRklpfGGG---YAVFA-GLEELLEYLENFRFTEEDIDYLRSLGIFD 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  82 ADYLNWLREFRFNpeqvtvsndngkLDIRlSGPWREVILWEVPLLAVISEMVhryrspqadVAQALDTLESKLVDFSALT 161
Cdd:cd01570  74 EEFLDYLRGFRFT------------GTIY-AIPEGEVVFPNEPLLTVEGPLI---------EAQLLETLLLNLINFQTLI 131
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 162 AGlDMSRFH-------LMDFGTRRRFSREVQETiVKRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQqispdla 234
Cdd:cd01570 132 AT-KAARVRlaaggrpLLEFGLRRAQGPDAALS-AARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFD------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268 235 nSQRAALAAWLEEYPDQLgIALTDciTMDA-------FLRDFGVEFASRYQ--GLRHDSGDPVEWGEKA-----IAHYEK 300
Cdd:cd01570 203 -DELAAFRAFAEAYPDNF-TLLVD--TYDTlrsglpnAIAVAKELGALGYRlvGVRIDSGDLAYLSKEArkmldEAGLTK 278
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15830268 301 LEIdpqsktlVFSDNLDlRKAVELYRHFSSRVqLSFGIGTRL-TC-DIPqvkPLNIVIKLV 359
Cdd:cd01570 279 VKI-------VASNDLD-EYTIAALNAQGAPI-DAFGVGTRLvTSqSQP---ALGGVYKLV 327
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
86-190 3.44e-04

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 41.98  E-value: 3.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  86 NWLREFR----FNPEQVTVSNDNGKLDIRLSGPWREVI-------------LWEVPLLAVISEMVHRYRSPQADVAQALD 148
Cdd:cd18005  84 NWKDELDtwghFEVGVYHGSRKDDELEGRLKAGRLEVVvttydtlrrcidsLNSINWSAVIADEAHRIKNPKSKLTQAMK 163
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15830268 149 TLESKLvdFSALTAGL---DMSRFH-LMD------FGTRRRFSREVQETIVK 190
Cdd:cd18005 164 ELKCKV--RIGLTGTLlqnNMKELWcLLDwavpgaLGSRSQFKKHFSEPIKR 213
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
123-383 5.15e-04

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 41.95  E-value: 5.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  123 VPLLavisemvhRYRSPQAdVAQALDTLESKLVDFSALTAgLDMSRF--------HLMDFGTRRR------FSrevqeti 188
Cdd:PLN02885 116 VPLM--------RIEGPLA-VVQLLETTFLTLVNYASLVA-TNAARHrlvagkskVLLEFGLRRAqgpdggIS------- 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  189 VKRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQ---------------------------------QISPDLAN 235
Cdd:PLN02885 179 ASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMgldeivdktlrsadgssvcedfvslvqewlsklQESSSLRG 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  236 -------SQRAALAAWLEEYPDQLgIALTDCI-TMDAFLRDF-GVEFASR---YQ--GLRHDSGD----PVEwGEKAIAH 297
Cdd:PLN02885 259 vfsetnqSELAAFTSYALAFPNSF-LALVDTYdVMKSGIPNFcAVALALNdlgYKavGIRLDSGDlaylSLE-ARKFFRT 336
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830268  298 YEKLEIDPQSKTLVFSDNLDLRKAV--ELYRHfSSRVQlSFGIGTRL-TCdipQVKP-LNIVIKLVECNGKPVAKLSDSP 373
Cdd:PLN02885 337 IEEELGVPGFGKMSITASNDINEETldALNKQ-GHEID-AFGIGTHLvTC---YAQPaLGCVYKLVEINGQPRIKLSEDV 411
                        330
                 ....*....|..
gi 15830268  374 GK-TI-CHDKAF 383
Cdd:PLN02885 412 EKvTIpCKKRCY 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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