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Conserved domains on  [gi|15830461|ref|NP_309234|]
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hypothetical protein ECs_1207 [Escherichia coli O157:H7 str. Sakai]

Protein Classification

SASA family carbohydrate esterase( domain architecture ID 12091508)

SASA family carbohydrate esterase containing a DUF1737 domains, similar to 9-O-Acetyl N-acetylneuraminic acid esterase from Escherichia coli O157:H7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF6645 super family cl48509
Family of unknown function (DUF6645); This presumed domain is functionally uncharacterized. ...
 489-557 3.81e-42

Family of unknown function (DUF6645); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and viruses, and is approximately 120 amino acids in length. The family is found in association with pfam03629, pfam08410.


The actual alignment was detected with superfamily member pfam20350:

Pssm-ID: 466500  Cd Length: 119  Bit Score: 148.23  E-value: 3.81e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15830461   489 LQKGGQIRCRFKVSGALAANQYVMAFYWPVSSLPQGVALTGDGGNNLLAAFYIQTDAKDLNVMYHNAKV 557
Cdd:pfam20350   1 LQKGGQIRCRFKVSGALAANQYVMALYWPVSSLPQGVTLTGDAGNNLLAAFYIQTDAKDLNVMYHNAKV 69
DUF1737 pfam08410
Domain of unknown function (DUF1737); This domain of unknown function is found at the ...
 5-53 1.30e-15

Domain of unknown function (DUF1737); This domain of unknown function is found at the N-terminus of bacterial and viral hypothetical proteins.


:

Pssm-ID: 429981  Cd Length: 51  Bit Score: 71.22  E-value: 1.30e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15830461     5 HYDVVRAASPSDLAKRITQKLKEGWQPYGSALISTAGY--GAEFIQPVVSE 53
Cdd:pfam08410   1 LYRLLTGPDDSAFCHRVTQALNEGWQLYGSPSITFDAArgVMRCGQAVVKE 51
SASA super family cl04187
Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this ...
 83-274 9.87e-11

Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.


The actual alignment was detected with superfamily member pfam03629:

Pssm-ID: 427409  Cd Length: 227  Bit Score: 62.22  E-value: 9.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830461    83 LAGQSN-----GMSYGEGLPLPDTfdSPDPRIKQLARRSTVtpggavckyndiIPADHCLHdvqdmsrlnhpkADLSKGQ 157
Cdd:pfam03629   7 LAGQSNmagrgGVENWDGVVPPEC--QPPPRILRLNADLEW------------EEAREPLH------------ADIDAKK 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830461   158 YGTVGQGLHIAKKLLPfIPANAGILLVPCCRGGSAFTtgadgtysdasgasenstRWGVDKPLYKDLIGRTKAALKknpK 237
Cdd:pfam03629  61 TCGVGPGMAFANALLR-APPGGVIGLVPCAVGGTSIE------------------EWARGGLLYQEMVRRAKAALK---G 118

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 15830461   238 NVLFAVVWMQGEFDfggTPVNHAAQ-----FGALVDKFRADL 274
Cdd:pfam03629 119 GEIKGILWYQGESD---TSDEEDAAaykekLEKLITDLRDDL 157
 
Name Accession Description Interval E-value
DUF6645 pfam20350
Family of unknown function (DUF6645); This presumed domain is functionally uncharacterized. ...
 489-557 3.81e-42

Family of unknown function (DUF6645); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and viruses, and is approximately 120 amino acids in length. The family is found in association with pfam03629, pfam08410.


Pssm-ID: 466500  Cd Length: 119  Bit Score: 148.23  E-value: 3.81e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15830461   489 LQKGGQIRCRFKVSGALAANQYVMAFYWPVSSLPQGVALTGDGGNNLLAAFYIQTDAKDLNVMYHNAKV 557
Cdd:pfam20350   1 LQKGGQIRCRFKVSGALAANQYVMALYWPVSSLPQGVTLTGDAGNNLLAAFYIQTDAKDLNVMYHNAKV 69
DUF1737 pfam08410
Domain of unknown function (DUF1737); This domain of unknown function is found at the ...
 5-53 1.30e-15

Domain of unknown function (DUF1737); This domain of unknown function is found at the N-terminus of bacterial and viral hypothetical proteins.


Pssm-ID: 429981  Cd Length: 51  Bit Score: 71.22  E-value: 1.30e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15830461     5 HYDVVRAASPSDLAKRITQKLKEGWQPYGSALISTAGY--GAEFIQPVVSE 53
Cdd:pfam08410   1 LYRLLTGPDDSAFCHRVTQALNEGWQLYGSPSITFDAArgVMRCGQAVVKE 51
SASA pfam03629
Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this ...
 83-274 9.87e-11

Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.


Pssm-ID: 427409  Cd Length: 227  Bit Score: 62.22  E-value: 9.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830461    83 LAGQSN-----GMSYGEGLPLPDTfdSPDPRIKQLARRSTVtpggavckyndiIPADHCLHdvqdmsrlnhpkADLSKGQ 157
Cdd:pfam03629   7 LAGQSNmagrgGVENWDGVVPPEC--QPPPRILRLNADLEW------------EEAREPLH------------ADIDAKK 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830461   158 YGTVGQGLHIAKKLLPfIPANAGILLVPCCRGGSAFTtgadgtysdasgasenstRWGVDKPLYKDLIGRTKAALKknpK 237
Cdd:pfam03629  61 TCGVGPGMAFANALLR-APPGGVIGLVPCAVGGTSIE------------------EWARGGLLYQEMVRRAKAALK---G 118

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 15830461   238 NVLFAVVWMQGEFDfggTPVNHAAQ-----FGALVDKFRADL 274
Cdd:pfam03629 119 GEIKGILWYQGESD---TSDEEDAAaykekLEKLITDLRDDL 157
 
Name Accession Description Interval E-value
DUF6645 pfam20350
Family of unknown function (DUF6645); This presumed domain is functionally uncharacterized. ...
 489-557 3.81e-42

Family of unknown function (DUF6645); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and viruses, and is approximately 120 amino acids in length. The family is found in association with pfam03629, pfam08410.


Pssm-ID: 466500  Cd Length: 119  Bit Score: 148.23  E-value: 3.81e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15830461   489 LQKGGQIRCRFKVSGALAANQYVMAFYWPVSSLPQGVALTGDGGNNLLAAFYIQTDAKDLNVMYHNAKV 557
Cdd:pfam20350   1 LQKGGQIRCRFKVSGALAANQYVMALYWPVSSLPQGVTLTGDAGNNLLAAFYIQTDAKDLNVMYHNAKV 69
DUF1737 pfam08410
Domain of unknown function (DUF1737); This domain of unknown function is found at the ...
 5-53 1.30e-15

Domain of unknown function (DUF1737); This domain of unknown function is found at the N-terminus of bacterial and viral hypothetical proteins.


Pssm-ID: 429981  Cd Length: 51  Bit Score: 71.22  E-value: 1.30e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15830461     5 HYDVVRAASPSDLAKRITQKLKEGWQPYGSALISTAGY--GAEFIQPVVSE 53
Cdd:pfam08410   1 LYRLLTGPDDSAFCHRVTQALNEGWQLYGSPSITFDAArgVMRCGQAVVKE 51
SASA pfam03629
Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this ...
 83-274 9.87e-11

Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.


Pssm-ID: 427409  Cd Length: 227  Bit Score: 62.22  E-value: 9.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830461    83 LAGQSN-----GMSYGEGLPLPDTfdSPDPRIKQLARRSTVtpggavckyndiIPADHCLHdvqdmsrlnhpkADLSKGQ 157
Cdd:pfam03629   7 LAGQSNmagrgGVENWDGVVPPEC--QPPPRILRLNADLEW------------EEAREPLH------------ADIDAKK 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830461   158 YGTVGQGLHIAKKLLPfIPANAGILLVPCCRGGSAFTtgadgtysdasgasenstRWGVDKPLYKDLIGRTKAALKknpK 237
Cdd:pfam03629  61 TCGVGPGMAFANALLR-APPGGVIGLVPCAVGGTSIE------------------EWARGGLLYQEMVRRAKAALK---G 118

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 15830461   238 NVLFAVVWMQGEFDfggTPVNHAAQ-----FGALVDKFRADL 274
Cdd:pfam03629 119 GEIKGILWYQGESD---TSDEEDAAaykekLEKLITDLRDDL 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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