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Conserved domains on  [gi|1447699394|ref|NP_309314|]
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acyl carrier protein [Escherichia coli O157:H7 str. Sakai]

Protein Classification

acyl carrier protein( domain architecture ID 10000754)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

CATH:  1.10.1200.10
Gene Ontology:  GO:0009245|GO:0006633|GO:0000036|GO:0000035
PubMed:  18059524|30543875|20662770
SCOP:  4000857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 9-92 1.64e-08

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 47.16  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699394  9 EQRKEVLMTIKTEIIQRLNIqrDEAQIDDDTALFgNGFKLDSVDATEIVVLLDKVFDIKISESDDPSYmRSINSLATFVI 88
Cdd:COG0236    1 MPREELEERLAEIIAEVLGV--DPEEITPDDSFF-EDLGLDSLDAVELIAALEEEFGIELPDTELFEY-PTVADLADYLE 76


                 ....
gi 1447699394 89 QKKN 92
Cdd:COG0236   77 EKLA 80
 
Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 9-92 1.64e-08

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 47.16  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699394  9 EQRKEVLMTIKTEIIQRLNIqrDEAQIDDDTALFgNGFKLDSVDATEIVVLLDKVFDIKISESDDPSYmRSINSLATFVI 88
Cdd:COG0236    1 MPREELEERLAEIIAEVLGV--DPEEITPDDSFF-EDLGLDSLDAVELIAALEEEFGIELPDTELFEY-PTVADLADYLE 76


                 ....
gi 1447699394 89 QKKN 92
Cdd:COG0236   77 EKLA 80
PRK09184 PRK09184
acyl carrier protein; Provisional
 2-87 8.57e-07

acyl carrier protein; Provisional


Pssm-ID: 181682  Cd Length: 89  Bit Score: 42.73  E-value: 8.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699394  2 STMNDAIEQRKEVLmtikteIIQRLNIQR-DEAQIDDDTALFGNGFKLDSVDATEIVVLLDKVFDIKIsESDDPSYMR-- 78
Cdd:PRK09184   1 MSSMTALERELAEL------IVEELNLEDvQPESIDADAPLYGEGLGLDSIDILEIALVISKRYGFQL-RSDNPDNQRif 73

                         90
                 ....*....|
gi 1447699394 79 -SINSLATFV 87
Cdd:PRK09184  74 aSLRALAAYV 83
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 9-90 3.37e-04

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 36.07  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699394   9 EQRKEVLMTIKTEIIQRLNIqRDEAQIDDDTALFGNGFklDSVDATEIVVLLDKVFDIKISES---DDPsymrSINSLAT 85
Cdd:smart00823  8 ERRRLLLDLVREQVAAVLGH-AAAEAIDPDRPFRDLGL--DSLMAVELRNRLEAATGLRLPATlvfDHP----TPAALAE 80


                  ....*
gi 1447699394  86 FVIQK 90
Cdd:smart00823 81 HLAAE 85
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 17-72 2.13e-03

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 33.31  E-value: 2.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 1447699394 17 TIKTEIIQRLNIqrDEAQIDDDTALFGNGfkLDSVDATEIVVLLDKVFDIKISESD 72
Cdd:pfam00550  2 RLRELLAEVLGV--PAEEIDPDTDLFDLG--LDSLLAVELIARLEEEFGVEIPPSD 53
 
Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 9-92 1.64e-08

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 47.16  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699394  9 EQRKEVLMTIKTEIIQRLNIqrDEAQIDDDTALFgNGFKLDSVDATEIVVLLDKVFDIKISESDDPSYmRSINSLATFVI 88
Cdd:COG0236    1 MPREELEERLAEIIAEVLGV--DPEEITPDDSFF-EDLGLDSLDAVELIAALEEEFGIELPDTELFEY-PTVADLADYLE 76


                 ....
gi 1447699394 89 QKKN 92
Cdd:COG0236   77 EKLA 80
PRK09184 PRK09184
acyl carrier protein; Provisional
 2-87 8.57e-07

acyl carrier protein; Provisional


Pssm-ID: 181682  Cd Length: 89  Bit Score: 42.73  E-value: 8.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699394  2 STMNDAIEQRKEVLmtikteIIQRLNIQR-DEAQIDDDTALFGNGFKLDSVDATEIVVLLDKVFDIKIsESDDPSYMR-- 78
Cdd:PRK09184   1 MSSMTALERELAEL------IVEELNLEDvQPESIDADAPLYGEGLGLDSIDILEIALVISKRYGFQL-RSDNPDNQRif 73

                         90
                 ....*....|
gi 1447699394 79 -SINSLATFV 87
Cdd:PRK09184  74 aSLRALAAYV 83
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 9-90 3.37e-04

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 36.07  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699394   9 EQRKEVLMTIKTEIIQRLNIqRDEAQIDDDTALFGNGFklDSVDATEIVVLLDKVFDIKISES---DDPsymrSINSLAT 85
Cdd:smart00823  8 ERRRLLLDLVREQVAAVLGH-AAAEAIDPDRPFRDLGL--DSLMAVELRNRLEAATGLRLPATlvfDHP----TPAALAE 80


                  ....*
gi 1447699394  86 FVIQK 90
Cdd:smart00823 81 HLAAE 85
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 17-72 2.13e-03

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 33.31  E-value: 2.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 1447699394 17 TIKTEIIQRLNIqrDEAQIDDDTALFGNGfkLDSVDATEIVVLLDKVFDIKISESD 72
Cdd:pfam00550  2 RLRELLAEVLGV--PAEEIDPDTDLFDLG--LDSLLAVELIARLEEEFGVEIPPSD 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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