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Conserved domains on  [gi|1134749630|ref|NP_309882|]
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stress response translation initiation inhibitor [Escherichia coli O157:H7 str. Sakai]

Protein Classification

translation initiation factor( domain architecture ID 10793129)

translation initiation factor similar to Escherichia coli Sui1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09019 PRK09019
stress response translation initiation inhibitor YciH;
1-108 1.88e-69

stress response translation initiation inhibitor YciH;


:

Pssm-ID: 181613  Cd Length: 108  Bit Score: 202.90  E-value: 1.88e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630   1 MSDSNSRLVYSTETGRIDEPKAAPVRSKGDGVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKDG 80
Cdd:PRK09019    1 MSDSNSRLVYSTDTGRIDEEKAKPERPKGDGIVRIQRQTSGRKGKGVCLITGLDLDDAELKKLAAELKKKCGCGGAVKDG 80

                          90       100
                  ....*....|....*....|....*...
gi 1134749630  81 VIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
Cdd:PRK09019   81 VIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
 
Name Accession Description Interval E-value
PRK09019 PRK09019
stress response translation initiation inhibitor YciH;
1-108 1.88e-69

stress response translation initiation inhibitor YciH;


Pssm-ID: 181613  Cd Length: 108  Bit Score: 202.90  E-value: 1.88e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630   1 MSDSNSRLVYSTETGRIDEPKAAPVRSKGDGVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKDG 80
Cdd:PRK09019    1 MSDSNSRLVYSTDTGRIDEEKAKPERPKGDGIVRIQRQTSGRKGKGVCLITGLDLDDAELKKLAAELKKKCGCGGAVKDG 80

                          90       100
                  ....*....|....*....|....*...
gi 1134749630  81 VIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
Cdd:PRK09019   81 VIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
SUI1 COG0023
Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; ...
 2-108 2.58e-50

Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; Translation initiation factor 1 (eIF-1/SUI1) is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439794  Cd Length: 112  Bit Score: 154.59  E-value: 2.58e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630   2 SDSNSRLVYSTETGRI--DEPKAAPVRSKGDGVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKD 79
Cdd:COG0023     4 KKDNSGLVYSTDPGREpeEEEEPAEELPPGDGIVRVRRETKGRKGKGVTVVTGLPLDDEDLKALAKELKKKCGCGGTVKD 83

                          90       100
                  ....*....|....*....|....*....
gi 1134749630  80 GVIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
Cdd:COG0023    84 GEIEIQGDHRDKIKALLEKKGYKVKRAGG 112
SUI1_rel TIGR01158
translation initation factor SUI1, putative, prokaryotic; This family of archaeal and ...
 8-108 1.91e-44

translation initation factor SUI1, putative, prokaryotic; This family of archaeal and bacterial proteins is homologous to the eukaryotic translation intiation factor SUI1 involved in directing the ribosome to the proper start site of translation by functioning in concert with eIF-2 and the initiator tRNA-Met. [Protein synthesis, Translation factors]


Pssm-ID: 273471  Cd Length: 101  Bit Score: 139.41  E-value: 1.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630   8 LVYSTETGRIDEPKAAPVRSKGDGVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKDGVIEIQGD 87
Cdd:TIGR01158   1 LVYSTECGLPKELCEEVAKPKEDQVVRIQRETRGRKGKGVTIIEGLDLSDIDLKELAKELKSKCGCGGTVKDGVIEIQGD 80

                          90       100
                  ....*....|....*....|.
gi 1134749630  88 KRDLLKSLLEAKGMKVKLAGG 108
Cdd:TIGR01158  81 HRDRVKDLLEKKGFKVKLIGG 101
YciH_like cd11567
Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic ...
 31-106 3.39e-30

Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. The function of non-eukaryotic family members is unclear. Escherichia coli YciH is a non-essential protein and was reported to be able to perform some of the functions of IF3 in prokaryotic initiation.


Pssm-ID: 211319  Cd Length: 76  Bit Score: 102.56  E-value: 3.39e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1134749630  31 GVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKDGVIEIQGDKRDLLKSLLEAKGMKVKLA 106
Cdd:cd11567     1 QKVRVRLEKRGRGGKTVTVIEGLPLSEEDLKELAKELKKKCGCGGTVKDGEIELQGDHREKIKELLEKKGFKVKKI 76
SUI1 pfam01253
Translation initiation factor SUI1;
30-100 1.99e-18

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 72.85  E-value: 1.99e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1134749630  30 DGVVRIQRQTSGRkGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAV-KDG---VIEIQGDKRDLLKSLLEAKG 100
Cdd:pfam01253   1 QPKIHIRVEQRGG-RKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVvKDGggeEIQVQGDQRDKVAELLTEKG 74
 
Name Accession Description Interval E-value
PRK09019 PRK09019
stress response translation initiation inhibitor YciH;
1-108 1.88e-69

stress response translation initiation inhibitor YciH;


Pssm-ID: 181613  Cd Length: 108  Bit Score: 202.90  E-value: 1.88e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630   1 MSDSNSRLVYSTETGRIDEPKAAPVRSKGDGVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKDG 80
Cdd:PRK09019    1 MSDSNSRLVYSTDTGRIDEEKAKPERPKGDGIVRIQRQTSGRKGKGVCLITGLDLDDAELKKLAAELKKKCGCGGAVKDG 80

                          90       100
                  ....*....|....*....|....*...
gi 1134749630  81 VIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
Cdd:PRK09019   81 VIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
SUI1 COG0023
Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; ...
 2-108 2.58e-50

Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; Translation initiation factor 1 (eIF-1/SUI1) is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439794  Cd Length: 112  Bit Score: 154.59  E-value: 2.58e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630   2 SDSNSRLVYSTETGRI--DEPKAAPVRSKGDGVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKD 79
Cdd:COG0023     4 KKDNSGLVYSTDPGREpeEEEEPAEELPPGDGIVRVRRETKGRKGKGVTVVTGLPLDDEDLKALAKELKKKCGCGGTVKD 83

                          90       100
                  ....*....|....*....|....*....
gi 1134749630  80 GVIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
Cdd:COG0023    84 GEIEIQGDHRDKIKALLEKKGYKVKRAGG 112
SUI1_rel TIGR01158
translation initation factor SUI1, putative, prokaryotic; This family of archaeal and ...
 8-108 1.91e-44

translation initation factor SUI1, putative, prokaryotic; This family of archaeal and bacterial proteins is homologous to the eukaryotic translation intiation factor SUI1 involved in directing the ribosome to the proper start site of translation by functioning in concert with eIF-2 and the initiator tRNA-Met. [Protein synthesis, Translation factors]


Pssm-ID: 273471  Cd Length: 101  Bit Score: 139.41  E-value: 1.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630   8 LVYSTETGRIDEPKAAPVRSKGDGVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKDGVIEIQGD 87
Cdd:TIGR01158   1 LVYSTECGLPKELCEEVAKPKEDQVVRIQRETRGRKGKGVTIIEGLDLSDIDLKELAKELKSKCGCGGTVKDGVIEIQGD 80

                          90       100
                  ....*....|....*....|.
gi 1134749630  88 KRDLLKSLLEAKGMKVKLAGG 108
Cdd:TIGR01158  81 HRDRVKDLLEKKGFKVKLIGG 101
PRK06824 PRK06824
translation initiation factor Sui1; Validated
 2-108 4.91e-38

translation initiation factor Sui1; Validated


Pssm-ID: 168689  Cd Length: 118  Bit Score: 123.64  E-value: 4.91e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630   2 SDSNSRLVYSTETGRI----DEPKAA-----PVRSKGDGVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCG 72
Cdd:PRK06824    3 LSALGGLVYSTEHGRHcpdcGQPVAAcickqAAAPAGDGIVRVRRETKGRGGKTVTVITGVPLAEDALKELAKELKRRCG 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1134749630  73 CGGAVKDGVIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
Cdd:PRK06824   83 TGGTLKDGVIEIQGDHVELLLAELLKRGFKAKKAGG 118
YciH_like cd11567
Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic ...
 31-106 3.39e-30

Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. The function of non-eukaryotic family members is unclear. Escherichia coli YciH is a non-essential protein and was reported to be able to perform some of the functions of IF3 in prokaryotic initiation.


Pssm-ID: 211319  Cd Length: 76  Bit Score: 102.56  E-value: 3.39e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1134749630  31 GVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKDGVIEIQGDKRDLLKSLLEAKGMKVKLA 106
Cdd:cd11567     1 QKVRVRLEKRGRGGKTVTVIEGLPLSEEDLKELAKELKKKCGCGGTVKDGEIELQGDHREKIKELLEKKGFKVKKI 76
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 32-104 8.15e-21

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 79.01  E-value: 8.15e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1134749630  32 VVRIQRQTSgRKGKGVCLITGIDLDdAELTKLAAELKKKCGCGGAVKD--GVIEIQGDKRDLLKSLLEAKGMKVK 104
Cdd:cd00474     1 KIHIKVEQR-SGGKKVTKVEGLPAY-IDLRKLADELKKKLGCGGSVEGekMEIEIQGDHTDQIIVALEEKGIDKD 73
PRK07451 PRK07451
translation initiation factor;
2-108 7.29e-20

translation initiation factor;


Pssm-ID: 236021  Cd Length: 115  Bit Score: 77.51  E-value: 7.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630   2 SDSNSRLVYStETGRIDEPKA----APVRSKGDGVVRIQRQTSGRKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAV 77
Cdd:PRK07451    6 SSSSKRIVYQ-EFGNVDNSAAlergVPDLPPQQQNLRVQATRSGRKGKTVTVITGFQHKPETLAKLLKQLKTQCGSGGTV 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1134749630  78 KDGVIEIQGDKRDLLKSLLEAKGMKVKLAGG 108
Cdd:PRK07451   85 KDNTIEIQGDHRQKILEILIKLGYKAKISGG 115
SUI1 pfam01253
Translation initiation factor SUI1;
30-100 1.99e-18

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 72.85  E-value: 1.99e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1134749630  30 DGVVRIQRQTSGRkGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAV-KDG---VIEIQGDKRDLLKSLLEAKG 100
Cdd:pfam01253   1 QPKIHIRVEQRGG-RKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVvKDGggeEIQVQGDQRDKVAELLTEKG 74
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
42-103 1.93e-17

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 70.72  E-value: 1.93e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1134749630  42 RKGKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKDGVIEIQGDKRDLLKSLLEAKGMKV 103
Cdd:PRK00939   34 RYGKEVTIIEGIDPKDIDLKELAKKLKSKLACGGTVKDGRIELQGDHRERVKELLIKMGFSE 95
eIF1_SUI1 cd11566
Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important ...
 33-104 5.86e-05

Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown.


Pssm-ID: 211318  Cd Length: 84  Bit Score: 38.28  E-value: 5.86e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1134749630  33 VRIQrQTSGRKgkgvCL--ITGIDlDDAELTKLAAELKKKCGCGGAVKDG-----VIEIQGDKRDLLKSLLEAKGMKVK 104
Cdd:cd11566     5 IRIQ-QRNGRK----TLttVQGLP-EEFDLKKILKAFKKEFACNGTVVEDpeygeVIQLQGDQRKNIKEFLLEEGIAKK 77
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 33-87 6.46e-05

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 38.31  E-value: 6.46e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749630  33 VRIQRQTSGRKgKGVCLITGIDLDDAELTKLAAELKKKCGCGGAVKDGV-----IEIQGD 87
Cdd:cd11607     3 VTIKRISRNKR-KFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTKGAegkdeIVIQGD 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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