|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
1-395 |
0e+00 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 656.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 1 MNLSLRRSTSALLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAI 80
Cdd:PRK10054 1 MNLSLRRSTSALLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 81 TAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQSI 160
Cdd:PRK10054 81 TAFASGFIAIPLVNNVTLVVLFFALINCAYSVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 161 NLPFWLAAICSAFPMFFIQIWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADGD 240
Cdd:PRK10054 161 NLPFWLAAICSAFPLVFIQIWVQRSEKAIATETGSVWSPSVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVVADSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 241 FAEKVVAVVLPVNAAMVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLIGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEY 320
Cdd:PRK10054 241 FAEKVVAVVLPVNAAMVVSLQYSVGRRLNAANIRPLMTAGTLCFVIGLVGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEY 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15831395 321 MLIDHIAPPGMKASYFSAQSLGWLGAAVNPLVSGVVLTTLPSSSLFIILALVIIAAWALMLKGINARPQRQPALC 395
Cdd:PRK10054 321 MLIDHIAPPGMKASYFSAQSLGWLGAAINPLVSGVILTTLPPWSLFVILALAIVAAWLLMLKGMRARPWGQPALC 395
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-382 |
2.14e-72 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 230.96 E-value: 2.14e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 21 IGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd17329 13 LGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQSINLPFWLAAICSAFPMFFIQI 180
Cdd:cd17329 93 IALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 181 WVKRSEKII--ATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIadGDFAEKVVAVVLPVNAAMVV 258
Cdd:cd17329 173 LLPETRPKRraAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI--LGLGESLLGLLLALNALLIV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 259 TLQYSVGRRLNPANIRALMTAGTLCFVIGLIGFIFSgNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSA 338
Cdd:cd17329 251 LLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFA-NTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15831395 339 QSLGW-LGAAVNPLVSGVVLTTLPSSSLFIILALVIIAAWALMLK 382
Cdd:cd17329 330 YALAWgLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-381 |
7.56e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.80 E-value: 7.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 21 IGRGATLPFMTIYLsRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd17325 10 LGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPMFFIQ 179
Cdd:cd17325 89 LARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAlGYRAPFLVCAALALLALVLAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 180 IWVKRSEKIIATETGSVWSP----KVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMviADGDFAEKVVAVVLPVNAA 255
Cdd:cd17325 169 LLLPEPRPPPNKRAVSAARLrsglRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA--ELGGLSPAQIGLLFGAQGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 256 MVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLIGFIFSGNSLLLWGMsAAVFTVGEIIYAPGEYMLIDHIAPPGMKASY 335
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLL-LALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15831395 336 FSAQSLGW-LGAAVNPLVSGVVLTTLPSSSLFIILALVIIAAWALML 381
Cdd:cd17325 326 MGLFNTAFsLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-348 |
9.31e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 92.34 E-value: 9.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 21 IGRGATLPFMTiYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:COG2814 24 LGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPMFFIQ 179
Cdd:COG2814 103 AARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 180 IWVKRSEKIIATETGSvwSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIAdgDFAEKVVAVVLPVNAAMVVT 259
Cdd:COG2814 183 RLLPESRPAARARLRG--SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL--GLSASAAGLLLALFGLGGVL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 260 LQYSVGRRLNPANIRALMTAGTLCFVIGLIGFIFSGNSLLLWGmSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSA- 338
Cdd:COG2814 259 GALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLL-ALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLy 337
|
330
....*....|
gi 15831395 339 QSLGWLGAAV 348
Cdd:COG2814 338 NSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-343 |
6.42e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.23 E-value: 6.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 21 IGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:pfam07690 10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPMFFIQ 179
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 180 IWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADG-DFAEKVVAVVLPVNAAMVV 258
Cdd:pfam07690 170 LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVlGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 259 TLQYSVGRRLNPANIRALMTAGTLCFVIGLIGFIFSGN--SLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYF 336
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329
|
....*..
gi 15831395 337 SAQSLGW 343
Cdd:pfam07690 330 GLYNTAG 336
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
26-381 |
3.14e-14 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 73.35 E-value: 3.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 26 TLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADK-FDKKRYMLLAITAFASGFIAIPLVNN----VTLVV 100
Cdd:cd17471 15 VLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNywvlLLVGV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 101 LFFALINCAYS-VFATVLKawFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFpMFFI 178
Cdd:cd17471 95 VLLSLGAAAFPqLFALARE--YADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVlGFTGLFLLAALLYLV-VALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 179 QIWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYvmVIADGDFAEKVVAVVLPVNAAMVV 258
Cdd:cd17471 172 VLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLY--VTNELGGSESWVGLLFGLAAALEI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 259 TLQYSVGRRLNPANIRALMTAGTLCFVIGLIGFIFSGNSLLLWG---MSAAVFTvgeIIYAPGEYMLIDHIAP-PGMKAS 334
Cdd:cd17471 250 PIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIAlqlLNAIFIG---ITAGLGISYFQDLMPGqPGLATT 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15831395 335 -YFSAQSLGWLGAAvnpLVSGVVLTTLPSSSLFIILALVIIAAWALML 381
Cdd:cd17471 327 lYSNASRIGSLLGG---LLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-376 |
3.15e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 73.37 E-value: 3.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 34 LSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVF 113
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 114 ATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQSINLPFWLAAICSAFPMFFIQIWVKRS-EKIIATE 192
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPkEKAKSSS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 193 TGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMVVTLQysVGRRLNPA- 271
Cdd:cd17474 185 ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF--VGRLLKKRf 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 272 NIRALMTAGTLCFVIGLIGFIFSGNSLLLWgMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSA-QSLGWLGAAVNP 350
Cdd:cd17474 263 GARRILVIGLLLYALSLLLLGFVPSLALLL-IAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLyNFVRFLGQAVGP 341
|
330 340
....*....|....*....|....*.
gi 15831395 351 LVSGVVLTTLPSSSLFIILALVIIAA 376
Cdd:cd17474 342 LLFGLLLEIFGLSAPFLVGAAIALAA 367
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-381 |
3.46e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 3.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 27 LPFMTIYLSrQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALI 106
Cdd:cd17489 16 LPVLPLYAH-DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 107 NCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPMFFIQIWVKRS 185
Cdd:cd17489 95 GIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHlGFAVLFIVAAVLALLALLLVFLVKDPP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 186 EKIIATETGSVWSPKVLLQDKALLwFTCSGFLASFVSGAFASCISQYVMVIADgdfaeKVVAVVLPVNAAMVVTLQYSVG 265
Cdd:cd17489 175 PVAAEEAEAGTRAFRRLVEKKVLP-PALILFLASIAYGAISTFLPLYAAERGI-----SNAGLFFTVYAIALLLSRPFSG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 266 RRLNPANIRALMTAGTLCFVIGLIGFIFSGNSLLLWGmSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQSLGW-L 344
Cdd:cd17489 249 KLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL-AAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFdL 327
|
330 340 350
....*....|....*....|....*....|....*..
gi 15831395 345 GAAVNPLVSGVVLTTLPSSSLFIILALVIIAAWALML 381
Cdd:cd17489 328 GIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-381 |
4.67e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 69.76 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 21 IGRGATLPFMTIYLsRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd06174 10 LARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQSINLPFW--LAAICSAFPMFFI 178
Cdd:cd06174 89 LGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAvfLIAAALALLAAIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 179 QIWVKRSEKIIATETGSVWSPKVLLQDKALLW----FTCSGFLASFVSGAFASCISQYVMVIADGDFAEKVVAVVLPVNA 254
Cdd:cd06174 169 LLLVVPDPPESARAKNEEASSKSVLKLLKRVLknpgLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 255 AMVVTLQYSVGRRL--NPANIRALMTAGTLCFVIGLIGFIFSGNSLLLWGMsAAVFTVGEIIYAPGEYMLIDHIAPPGMK 332
Cdd:cd06174 249 GLAGALGSLLLGLLsdRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL-LLLLGFGLGGLLPLSFALIAELFPPEIR 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 15831395 333 ASYFSAQSL-GWLGAAVNPLVSGVVLTTLPSSSLFIILALVIIAAWALML 381
Cdd:cd06174 328 GTAFGLLNTfGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
3-169 |
6.56e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.53 E-value: 6.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 3 LSLRRSTSALLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITA 82
Cdd:cd17325 195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 83 FASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQ-SIN 161
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAfGFA 354
|
....*...
gi 15831395 162 LPFWLAAI 169
Cdd:cd17325 355 TPFLAAAA 362
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
29-381 |
1.14e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 69.16 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 29 FMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKR-----YMLLAITAFASGFIAIPLV------NNVT 97
Cdd:COG2211 32 YLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTApdlsptGKLI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 98 LVVLFFALINCAYSVFATVLKAWFADnLSSTSK--TKIFSINYTMLNIGWTVGPPLGTLLV-------MQSINLPFWLAA 168
Cdd:COG2211 112 YALVTYLLLGLAYTLVNIPYSALGAE-LTPDYEerTRLSSWRFAFAGLGGLLASVLPPPLVaafggdaALGYRLTALIFA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 169 ICSAFPMFFIQIWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIAdgDFAEKVVAV 248
Cdd:COG2211 191 VLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAALVGL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 249 VLPVNAAMVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLIGFIFSG-NSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIA 327
Cdd:COG2211 269 LLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLADVV 348
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 328 PPG-------MKASYFSAQSLGW-LGAAVNPLVSGVVL--------TTLPSSSLFIILALVIIAAWALML 381
Cdd:COG2211 349 DYDewktgrrREGLYFGIFTFAIkLGQALAGALAGLLLalfgyvagAAQSPSALTGIRLLFFLLPAVLLL 418
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
27-375 |
2.73e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 67.63 E-value: 2.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 27 LPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALI 106
Cdd:cd17472 16 LPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 107 -NCAYSvfaTVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLV-MQSINLPFWLAAICSAFPMFFIQIWVKR 184
Cdd:cd17472 96 gSGAIS---SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAaHLGVSGLFLITAILSLVSLLILLFFVPD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 185 SEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADG-DFAEKV-VAVVLPVNAAMVVTLQY 262
Cdd:cd17472 173 PPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGkGQLWKVyLPAILIGFILMVPFVIY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 263 SVGRRlnpaNIRALMTAGTLCFVIGLIGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFS-AQSL 341
Cdd:cd17472 253 AEKKG----KMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGiYNTS 328
|
330 340 350
....*....|....*....|....*....|....
gi 15831395 342 GWLGAAVNPLVSGVVLTTLPSSSLFIILALVIIA 375
Cdd:cd17472 329 QFLGSFLGGALGGLLWGLLGYSSVFLTILILALL 362
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-382 |
3.69e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 63.75 E-value: 3.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 21 IGRGATLPFMTIYLSRQYSLSVD--LIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVtL 98
Cdd:cd17330 10 LGFGIVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL-W 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 99 VVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLV-MQSINLPFWLAAICSAFPMFF 177
Cdd:cd17330 89 LLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLStPYGYALPFLVAAALALLNLVL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 178 IQIWVKRSEKIIATetgsvwspkvllqdkallwftcsGFLASFVSGAFASCISQYVmvIADGDFAEKVVAVVLPVNAAMV 257
Cdd:cd17330 169 VLFFLPPLRRLLLV-----------------------YFLIALAFAGLESVFSLFL--KDRFGFSPSQIGLLLALVGIAG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 258 VTLQYSVGRRLNPA-NIRALMTAGTLCFVIGLIGFIFSGNSLLLWgMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYF 336
Cdd:cd17330 224 ILAQLLLIPRLAKRlGERKLLRLGLLLAIIGLLLLPFASSVPLLV-LAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15831395 337 S-AQSLGWLGAAVNPLVSGVVLTTLPSSSLFIILALVIIAAWALMLK 382
Cdd:cd17330 303 GiIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-376 |
1.06e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 62.63 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 41 SVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLV-----NNVTLVVLFFALINCAYSVFAT 115
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 116 VLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQ-SINLPFWLAAIC---SAFPMFFIQIWVKRS--EKII 189
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALlGPGGAFAINALSfllSALLLLFIRRPPPAApgESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 190 ATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADGDfaEKVVAVVLPVNAAMVVTLQYSVGRRLN 269
Cdd:cd06173 192 LLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGG--AAGYGLLLAAFGVGALLGALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 270 PANIRALMTAGTLCFVIGLIGFIFSgNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQ-SLGWLGAAV 348
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLS-PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYnALNSGAMPL 348
|
330 340
....*....|....*....|....*...
gi 15831395 349 NPLVSGVVLTTLPSSSLFIILALVIIAA 376
Cdd:cd06173 349 GALLAGLLADALGLSAVFLLAGALLLLA 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-381 |
1.90e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.80 E-value: 1.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 34 LSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVF 113
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 114 ATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPMFFIQIWVKRSEKIIATE 192
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 193 TGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADGDfAEKVVAVVLPVNAAMVVTLQYsVGRRLNPAN 272
Cdd:cd17324 185 LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFS-SSAIIGLLLLFGVAGVVGSPL-AGRLADRGG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 273 IRALMTAGTLCFVIGLiGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAP--PGMKASYFSAqsLGWLGAAVNP 350
Cdd:cd17324 263 RRALLIALLLLAAALL-LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPeaRGLASSLYLA--AYNLGGALGA 339
|
330 340 350
....*....|....*....|....*....|.
gi 15831395 351 LVSGVVLTTLPSSSLFIILALVIIAAWALML 381
Cdd:cd17324 340 ALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-311 |
2.75e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.34 E-value: 2.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 33 YLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSV 112
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 113 F---ATVLkawfADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQSINLPFW----LAAICSAFPMFFIQIWVKRS 185
Cdd:cd17478 101 FhpeGARL----ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLilliIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 186 EKiiATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVI-ADGDFAEKVVAVVLPVNAAMVVTLQYsV 264
Cdd:cd17478 177 AK--KAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRgYSLVFAGLLLSLFLFAGAIGTLIGGP-L 253
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 15831395 265 GRRLNPaniRALMTAGTLCFVIGLIGFIFSGNSLLLWGMSAAVFTVG 311
Cdd:cd17478 254 SDRFGR---RRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLF 297
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-381 |
1.91e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 55.66 E-value: 1.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 44 LIGYAMTI-ALTIgVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFA 122
Cdd:cd17473 36 LVPLLLTLpALFI-ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 123 DNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQSINLPFWLAAIcsAFPMFFIQIWVKRSEKIIATETGSVWSPKVL 202
Cdd:cd17473 115 DYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLL--ALPVLILVLLFLPEPARKSKSAASPGAATAA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 203 LQDKALLWFTCsgFLASFVSGAFASCISQYVMVIAD-GDFAEKVVAVVLPVNAAMVVTLQYSVGRRLNPANIRALMTAGT 281
Cdd:cd17473 193 ALPWKRVLPIY--FLAFLAMLLFYVIPIQLPFLLQErGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 282 LCFVIGLIGFIFSGN-SLLLWGMSAAVFTVGEIIyaPGEYMLIDHIAPPGMKASYFSA-QSLGWLGAAVNPLVSGVVLTT 359
Cdd:cd17473 271 ALMALGFLLLALASGlWVVLLGAILAGLGFGLLL--PTLNSWAMSLVPPELRGRAMGIvTSAFFLGQFLSPLVLGPLVNL 348
|
330 340
....*....|....*....|...
gi 15831395 360 LPS-SSLFIILALVIIAAWALML 381
Cdd:cd17473 349 TGGlSGAFLILGVLALVLAIVLL 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-382 |
2.94e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 55.25 E-value: 2.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 33 YLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSV 112
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 113 FATVLKAWFADnLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQSINLP-----FWLAAICSAFPMFFIQIWVKRSEK 187
Cdd:COG0738 113 LDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSwhlpyLILAVLLLLLALLFLRSKLPEIEE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 188 IIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMviADGDFAEKVVAVVLPVNAAMVVTLQYSVGRR 267
Cdd:COG0738 192 EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK--DVLGLSEATAALGLSLFWGGMTIGRFLGGFL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 268 LNPANIRALMTAGTLCFVIGLIGFIFSGN------SLLLWGMSAAVF---TVGEIIYAPGEYmlidhiapPGMKASYFSA 338
Cdd:COG0738 270 LKRFGPVRLLRLSALLAAVGLLLALLAPGpwlaliGLALVGLGLSLMfptIFSLALDGLGKR--------TAAAVSAVLI 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15831395 339 qsLGWLGAAVNPLVSGVV--LTTLPSSSLFIILALVIIAAWALMLK 382
Cdd:COG0738 342 --MGIVGGAIGPPLIGFLadAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
40-381 |
3.64e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.86 E-value: 3.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 40 LSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLL---AITAFASGFIAipLVNNVTLVVLFFALINCAYSVFATV 116
Cdd:cd17370 31 ASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIlgyGLSALAKPLLA--LAGSWQLVLLLRILERLGKGIRTPP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 117 LKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQSIN---LPFWLAAICSAFPMFFIQIWVKRSEKIIATET 193
Cdd:cd17370 109 RDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyrTIFLLAAIPALLALLILLFVVKEYPRPPKLRK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 194 GSVWSPKVLLqDKALLWFTCSGFLASFVSGAFAscisqyVMVIADGDFAEKVVAVVLPVNAAMVV--TLQYSVGRRLNPA 271
Cdd:cd17370 189 KSKKTSLKKL-PKAFWLYLLAVALFALGNFSFA------FLILRAQELGLSAALIPLLYALFNLVyaLAAYPAGRLSDRI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 272 NIRALMTAGTLCFVIGLIGFIFSGNSLLLWgMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKAS----YFSAQSLGWLGAA 347
Cdd:cd17370 262 GRKKLLILGYLSLALAYLGFALGSSLWLLL-LGFILWGLYMGAQESIERAAVADLVPAELRGTayglFNTVVGIGWLLAS 340
|
330 340 350
....*....|....*....|....*....|....
gi 15831395 348 vnpLVSGVVLTTLPSSSLFIILALVIIAAWALML 381
Cdd:cd17370 341 ---LIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-380 |
5.44e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.10 E-value: 5.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 21 IGRGATLPFMTIYLSRQySLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd17477 10 LGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTlLVMQSINLPFWLAAICSAF---PMFF 177
Cdd:cd17477 89 LLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFLIAAVLLLLalvPLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 178 IQIWVKRSEKiiaTETGSVWspkvllqdkALLWFTCSGFLASFVSGAF-ASCISQYVMVIADGDFAEKVVAVVLPVNAAM 256
Cdd:cd17477 168 TRRAAPEIEE---AESISLR---------RLLRIAPLALLGAFVAGFLeGAFYSLLPLYGLRLGLSVAQAALLLAAFVLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 257 VVTLQYSVGRRLNPANIRALMTAGTLCFVIGLIGF-IFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASY 335
Cdd:cd17477 236 GLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLpLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAAN 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15831395 336 FSAQSLGWLGAAVNPLVSGVVLTTLPSSSLFIILALVIIAAWALM 380
Cdd:cd17477 316 AALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-187 |
2.22e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.18 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 29 FMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFAS--GFIAIPLVNNVTLVVLFFALI 106
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAalALLLLALLPSPALAIALLFLA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 107 NCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPL-GTLLVMQSINLPFWLAAICSAFPMFFIQIWVKRS 185
Cdd:COG2271 282 GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLvGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
..
gi 15831395 186 EK 187
Cdd:COG2271 362 RK 363
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
32-177 |
3.09e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 3.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 32 IYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYS 111
Cdd:cd17370 223 ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMG 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15831395 112 VFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPL-GTLLVMQSINLPFWLAAICS--AFPMFF 177
Cdd:cd17370 303 AQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIaGYLWDLISPSAAFLFSAVLAliALLLLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-381 |
3.78e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.81 E-value: 3.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 26 TLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFAL 105
Cdd:COG2223 23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 106 INCA----YSVFATVLKAWFADNLsstsKTKIFSINYTMLNIGWTVGPPLGTLLV-MQSINLPFWLAAICSAFPMFFIQI 180
Cdd:COG2223 103 LGIGgggsFAVGIALVSKWFPPDR----RGLALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVAVLAWL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 181 WVKRS-EKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMVVT 259
Cdd:COG2223 179 FLRDPpAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 260 LQY-SVGRRLNPANIRALMTAGTLCFVIGLigFIFSGNSLLLWGMSAAVFTVGEIIYAPGeYMLIDHIAPPGMKASYFSA 338
Cdd:COG2223 259 PLGgWLSDRIGGRRVLLIVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAV-FALVPDIFPTKNAGAVYGL 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15831395 339 QSLGW-LGAAVNPLVSGVVLTTLPS-SSLFIILALVIIAAWALML 381
Cdd:COG2223 336 VGAAGgLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTL 380
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-381 |
5.88e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 5.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 25 ATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFA 104
Cdd:COG2271 27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 105 LINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQ-SINLPFWLAAICSAFPMFFiqiwvk 183
Cdd:COG2271 107 LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAfGWRAAFLILGLPGLLLALL------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 184 rsekiiatetgsvwspkvllqdkALLWFTCSGFLASFVSGAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMVVTLqyS 263
Cdd:COG2271 181 -----------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSL--L 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 264 VGR---RLNPANIRALMTAGTLCFVIGLIGFIFSGNSLLLWGMSAAVFTVGeiIYAPGEYMLIDHIAPPGMKASYFS-AQ 339
Cdd:COG2271 236 GGWlsdRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG--GAFGLLWALAAELFPKKARGTASGlVN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15831395 340 SLGWLGAAVNPLVSGVVLTTLPSSSLFIILALVIIAAWALML 381
Cdd:COG2271 314 TFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-383 |
3.42e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.72 E-value: 3.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 34 LSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSV- 112
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVg 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 113 ---FATVLKAWFADNLSStsktkIFSINYTMLNIGWTVGPPLGT-LLVMQSINLPFWLAAICSAFPMFFIqIWVKRSEKI 188
Cdd:COG2807 124 nvlLPGLIKRWFPDRVGL-----MTGLYTAAMGLGAALAAGLTVpLAAALGWRGALAVWALLALLALLLW-LPLLRRRPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 189 IATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVI-ADGDFAEKVVAVVLPVNAAMVVTLQYSVGRR 267
Cdd:COG2807 198 AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAgLSAATAGLLLSLFQLAGIPGSLLVPLLADRL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 268 LNPaniRALMTAGTLCFVIGLIGFIFS-GNSLLLWGMSAAVFTVGEIIYApgeYMLIDHIAPPGMKASYFS--AQSLGWL 344
Cdd:COG2807 278 GDR---RPLLLLLGLLGLAGLLGLLLApGSLPWLWAVLLGLGQGGLFPLA---LTLIGLRARTPAEAAALSgmAQSVGYL 351
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15831395 345 GAAVNPLVSGVVLTTLPS--SSLFIILALVIIAAWALMLKG 383
Cdd:COG2807 352 LAALGPLLVGALHDATGSwtAALLLLAALAVLMLVAGLLAG 392
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-156 |
1.06e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 21 IGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLV--NNVTL 98
Cdd:COG2211 242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWL 321
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15831395 99 VVLFFALINCAYSVFATVLKAWFADNL-SSTSKT------KIFSINYTMLNIGWTVGPPLGTLLV 156
Cdd:COG2211 322 LLVLAALAGIGLGAILVLPWAMLADVVdYDEWKTgrrregLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
46-390 |
1.94e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 46.53 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 46 GYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFADNL 125
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 126 SSTSKTKIFSINYTmlniGWTVGPPLGTLLVMQSINLP---------FWLAAIcSAFPMFFIQIWVKRSEKIIATETGSV 196
Cdd:cd17371 117 PARHRGKALGYVQS----GWAVGWLLATLLAALLFPLLppeiawrvlFLLGAL-PALLVLFIRRFVKEPPQWQAARAARR 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 197 WSPK----VLLQDKALLWFTCSGFL-ASFVSGAFAScISQYVMVIADG--DFAEKVVAVVLPV-NAAMVV------TLQY 262
Cdd:cd17371 192 HFADrpslRELFSPPLLRTTLLASLlATGALGGYYG-ITTWLPSYLTGerGLSFEGSAGYLVVtILGGFLgylaggFLAD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 263 SVGRRlnpaNIRALMTAGTLCFVIgLIGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMliDHIAPPGMKAS-YFSAQSL 341
Cdd:cd17371 271 RIGRR----NNFALFALGSAISIL-LYFFLPLSPTLILILGFPLGFFASGPFSGMGAYL--TELFPTAVRATaQGFCYNV 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 15831395 342 GWLGAAVNPLVSGVVLTtlpSSSLFIILALVIIAAWALMLKGINARPQR 390
Cdd:cd17371 344 GRIIGALFPFLVGFLAT---SGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-183 |
3.94e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.02 E-value: 3.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 57 VVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSI 136
Cdd:TIGR00880 12 LIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGL 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 15831395 137 NYTMLNIGWTVGPPLGTLLVMQSI-NLPFWLAAICSAFPMFFIQIWVK 183
Cdd:TIGR00880 92 MSAGIALGPLLGPPLGGVLAQFLGwRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-376 |
1.36e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.80 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 22 GRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVL 101
Cdd:cd17355 17 GIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 102 FFALI------NCAYSVFATVLKAWFAdnlssTSKTKIFSINYTMLNIGWTVGPPLGTLLVMQsinLPF-----WLAAIC 170
Cdd:cd17355 97 LWGLLggggagTLAAVAFATVAAWWFE-----RRRGLALGILTAGGGLGSLVFLPLGAALIEA---FGWrtallVLALLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 171 SAFPMFFIQIWVKRSEKI------IATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFascISQYVMVIADGDFAEK 244
Cdd:cd17355 169 LLVLVPVLLLLRRRPADLalraydDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGL---IVHLVPYLADRGISPA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 245 VVAVVLPVNAAMVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLIGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLID 324
Cdd:cd17355 246 AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15831395 325 HIAPPGMKASYFSAQSLGW-LGAAVNPLVSGVVLTTLPS--SSLFIILALVIIAA 376
Cdd:cd17355 326 RYFGARSYGTLFGLVFAPHqLGSALGPWLGGLLYDRTGSytAAWALAVALGLIAA 380
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
37-316 |
1.01e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.02 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 37 QYSLSVDLIGYAmtialtIGVVFslgFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVFATV 116
Cdd:cd17320 37 QLTLSAYLLGFA------LGQLL---YGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 117 LKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLVM----QSINLPFWLAAICSAFPMFFIQIWVKRSEKIIATE 192
Cdd:cd17320 108 ARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLffgwRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 193 TGSVWSPKVLLQDKAllwFTCSGFLASFVSGAFASCISQY-VMVIADGDFAEKVVAVVLPVNAAMVVTLQYSVGRRLNPA 271
Cdd:cd17320 188 SSLLRAYKRVLKNRR---FLGYALALGLSFAGLFAYLAAApFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRF 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 15831395 272 NIRALMTAGTLCFVIGLIGFIFSGnslLLWGMSAAVFTVGEIIYA 316
Cdd:cd17320 265 GPRRLLRLGLLLLLAAALVLLLAA---LLGGLSLWPLVAPLFLIF 306
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
29-122 |
1.15e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.97 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 29 FMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKR-YMLLAITAFASGFIAIPLV---NNVTLVVLFFA 104
Cdd:cd17369 250 FALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPvYLAGALLAALFAFPFFWLLdtgSTWLIVLAAVV 329
|
90
....*....|....*...
gi 15831395 105 LINCAYSVFATVLKAWFA 122
Cdd:cd17369 330 VLGVLHGMMYGPQAAFLA 347
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-177 |
4.84e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 21 IGRGATLPFMTIYLSrqySLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVV 100
Cdd:cd17489 208 IAYGAISTFLPLYAA---ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLL 284
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15831395 101 LFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLV-MQSINLPFWLAAICSAFPMFF 177
Cdd:cd17489 285 LAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAeLFGYRAMFLLAAVVVLLALVL 362
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
34-288 |
6.21e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 6.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 34 LSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVF 113
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 114 ATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTVGPPLGTLLV-MQSINLPFWLAAICSAFPMFFIQIWVKRSEKIIATE 192
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVaALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831395 193 TGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMVVTLQYSVGRRLNPAN 272
Cdd:COG0477 200 ALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALL 279
|
250
....*....|....*.
gi 15831395 273 IRALMTAGTLCFVIGL 288
Cdd:COG0477 280 LLLLLLLLLLLLALLL 295
|
|
| |
