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Conserved domains on  [gi|15831529|ref|NP_310302|]
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phage DNA replication protein [Escherichia coli O157:H7 str. Sakai]

Protein Classification

ATP-binding protein( domain architecture ID 11485873)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to the ATPase region of Aquifex aeolicus DnaC helicase loader and to Mycobacterium tuberculosis putative ATP-binding protein Rv3427c in insertion sequence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12377 PRK12377
putative replication protein; Provisional
 1-246 0e+00

putative replication protein; Provisional


:

Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 504.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    1 MKNIAAVGVLERIRRLAPQGAVPPYRTVEEWREWQLAEGRKRSEEINRLNHQVRVEKILNRAGIQPLHRKCSFGNYRVQN 80
Cdd:PRK12377   1 MKNIATGGVLERIRRLAPQGVQPPFRTVDEWREWQLAEGRKRSEEINRQNQQLRVEKILNRSGIQPLHRKCSFANYQVQN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   81 DGQRHALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKFLQE 160
Cdd:PRK12377  81 DGQRYALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLLAKGRSVIVVTVPDVMSRLHESYDNGQSGEKFLQE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  161 LCGVDLLVLDEIGMQRDTRNEQVTLNQIVDRRTASMRSVGMLTNLNHAAMSTLLGDRVMDRMTMNGGRWVNFNWESWRSN 240
Cdd:PRK12377 161 LCKVDLLVLDEIGIQRETKNEQVVLNQIIDRRTASMRSVGMLTNLNHEAMSTLLGERVMDRMTMNGGRWVNFNWESWRPN 240


                 ....*.
gi 15831529  241 VGRQGM 246
Cdd:PRK12377 241 VSHLRI 246
 
Name Accession Description Interval E-value
PRK12377 PRK12377
putative replication protein; Provisional
 1-246 0e+00

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 504.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    1 MKNIAAVGVLERIRRLAPQGAVPPYRTVEEWREWQLAEGRKRSEEINRLNHQVRVEKILNRAGIQPLHRKCSFGNYRVQN 80
Cdd:PRK12377   1 MKNIATGGVLERIRRLAPQGVQPPFRTVDEWREWQLAEGRKRSEEINRQNQQLRVEKILNRSGIQPLHRKCSFANYQVQN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   81 DGQRHALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKFLQE 160
Cdd:PRK12377  81 DGQRYALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLLAKGRSVIVVTVPDVMSRLHESYDNGQSGEKFLQE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  161 LCGVDLLVLDEIGMQRDTRNEQVTLNQIVDRRTASMRSVGMLTNLNHAAMSTLLGDRVMDRMTMNGGRWVNFNWESWRSN 240
Cdd:PRK12377 161 LCKVDLLVLDEIGIQRETKNEQVVLNQIIDRRTASMRSVGMLTNLNHEAMSTLLGERVMDRMTMNGGRWVNFNWESWRPN 240


                 ....*.
gi 15831529  241 VGRQGM 246
Cdd:PRK12377 241 VSHLRI 246
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
103-238 2.01e-22

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 91.77  E-value: 2.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529 103 NFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSgEKFLQELCGVDLLVLDEIGMQRDTRNEQ 182
Cdd:COG1484 101 NLILLGPPGTGKTHLAIALGHEACRAGYRVRFTTAPDLVNELKEARADGRL-ERLLKRLAKVDLLILDELGYLPLDAEGA 179

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15831529 183 VTLNQIVDRRtASMRSVGMLTNLNHAAMSTLLGDRVM-----DRMTMNgGRWVNFNWESWR 238
Cdd:COG1484 180 ELLFELISDR-YERRSTIITSNLPFSEWGEVFGDPTLatailDRLVHH-AHIIELKGESYR 238
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 95-238 6.84e-20

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 84.83  E-value: 6.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   95 DELMTG-----CTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGqSGEKFLQELCGVDLLVL 169
Cdd:NF038214  79 RELATLdfierAENVLLLGPPGTGKTHLAIALGYAACRQGYRVRFTTAADLVEQLAQARADG-RLGRLLRRLARYDLLII 157

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15831529  170 DEIGMQRDTRNEQVTLNQIVDRR--TASMrsvgMLT-NLNHAAMSTLLGDRVM-----DRMTMNgGRWVNFNWESWR 238
Cdd:NF038214 158 DELGYLPFSREGANLLFELIADRyeRGST----IITsNLPFSEWGEVFGDPTLaaailDRLVHH-AHILELKGESYR 229
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 30-238 9.97e-16

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 74.02  E-value: 9.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    30 EWREWQLAEGRKRSEEINRLNHQVRVEKIlnragiqPLHRKCSFGNYRVQNDGQRHALSQAKSIAdeLMTGCTNFVFSGK 109
Cdd:pfam01695  30 EEFLEHLLEEELAWRDTRRLERLLRMAKL-------PPHKTLEDFDFTFAPGLDQRIVAELASLS--FIDRAQNVVLLGP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   110 PGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKfLQELCGVDLLVLDEIGMQRDTRNEQVTLNQIV 189
Cdd:pfam01695 101 PGVGKTHLAIALGVEACRAGYSVRFTSAADLVNQLKRAHGDGKLTRK-LQQLLKPDVLILDEWGYLPLDQAEANLLFQVI 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15831529   190 DRRTASmRSVGMLTNLNHAAMSTLLGDRVM-----DRMTMNGGRwVNFNWESWR 238
Cdd:pfam01695 180 SKRYEH-RSIILTSNLPFGEWGQVFGDAVLatailDRLLHHCHI-VPIKGESYR 231
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 82-193 2.96e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 57.16  E-value: 2.96e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  82 GQRHALSQAKSIADELMTGctNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKFLQEL 161
Cdd:cd00009   2 GQEEAIEALREALELPPPK--NLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFEL 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15831529 162 ---CGVDLLVLDEIG-MQRDTRNEQV-TLNQIVDRRT 193
Cdd:cd00009  80 aekAKPGVLFIDEIDsLSRGAQNALLrVLETLNDLRI 116
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 103-222 7.04e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.45  E-value: 7.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    103 NFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKFLQ--------------ELCGVDLLV 168
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASgsgelrlrlalalaRKLKPDVLI 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 15831529    169 LDEIGMQRDTRNEQVTLNQIVDRRTASMRSVG-----MLTNLNHAAMSTLLGDRVMDRM 222
Cdd:smart00382  84 LDEITSLLDAEQEALLLLLEELRLLLLLKSEKnltviLTTNDEKDLGPALLRRRFDRRI 142
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 56-172 1.33e-06

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 48.68  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    56 EKILNRAGIQPLHRKCSFGNYrVQNDGQRHALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAK--GRSVI 133
Cdd:TIGR00362  93 EAPAPPSSASGLNPKYTFDNF-VVGKSNRLAHAAALAVAENPGKAYNPLFIYGGVGLGKTHLLHAIGNEILENnpNAKVL 171

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 15831529   134 IVTVSDVMSVLHDGYDNGQSgEKFLQELCGVDLLVLDEI 172
Cdd:TIGR00362 172 YVSSEKFTNDFVNALRNNKM-EEFKEKYRSVDLLLIDDI 209
 
Name Accession Description Interval E-value
PRK12377 PRK12377
putative replication protein; Provisional
 1-246 0e+00

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 504.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    1 MKNIAAVGVLERIRRLAPQGAVPPYRTVEEWREWQLAEGRKRSEEINRLNHQVRVEKILNRAGIQPLHRKCSFGNYRVQN 80
Cdd:PRK12377   1 MKNIATGGVLERIRRLAPQGVQPPFRTVDEWREWQLAEGRKRSEEINRQNQQLRVEKILNRSGIQPLHRKCSFANYQVQN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   81 DGQRHALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKFLQE 160
Cdd:PRK12377  81 DGQRYALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLLAKGRSVIVVTVPDVMSRLHESYDNGQSGEKFLQE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  161 LCGVDLLVLDEIGMQRDTRNEQVTLNQIVDRRTASMRSVGMLTNLNHAAMSTLLGDRVMDRMTMNGGRWVNFNWESWRSN 240
Cdd:PRK12377 161 LCKVDLLVLDEIGIQRETKNEQVVLNQIIDRRTASMRSVGMLTNLNHEAMSTLLGERVMDRMTMNGGRWVNFNWESWRPN 240


                 ....*.
gi 15831529  241 VGRQGM 246
Cdd:PRK12377 241 VSHLRI 246
PRK07952 PRK07952
DNA replication protein DnaC; Validated
 1-241 1.31e-101

DNA replication protein DnaC; Validated


Pssm-ID: 181180 [Multi-domain]  Cd Length: 244  Bit Score: 295.14  E-value: 1.31e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    1 MKNIAavGVLERIRRLAPQGAVPPYRTVEEWREWQLAEGRKRSEEINRLNHQVRVEKILNRAGIQPLHRKCSFGNYRVQN 80
Cdd:PRK07952   1 MKNVG--DLMQRLQKMMPAHIKPAFKTGEELLAWQKEQGRIRSAALERENRAMKMQRTFNRSGIRPLHQNCSFENYRVEC 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   81 DGQRHALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQ-SGEKFLQ 159
Cdd:PRK07952  79 EGQMNALSKARQYVEEFDGNIASFIFSGKPGTGKNHLAAAICNELLLRGKSVLIITVADIMSAMKDTFSNSEtSEEQLLN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  160 ELCGVDLLVLDEIGMQRDTRNEQVTLNQIVDRRTASMRSVGMLTNLNHAAMSTLLGDRVMDRMTMNGGRWVNFNWESWRS 239
Cdd:PRK07952 159 DLSNVDLLVIDEIGVQTESRYEKVIINQIVDRRSSSKRPTGMLTNSNMEEMTKLLGERVMDRMRLGNSLWVIFNWDSYRS 238


                 ..
gi 15831529  240 NV 241
Cdd:PRK07952 239 RV 240
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
103-238 2.01e-22

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 91.77  E-value: 2.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529 103 NFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSgEKFLQELCGVDLLVLDEIGMQRDTRNEQ 182
Cdd:COG1484 101 NLILLGPPGTGKTHLAIALGHEACRAGYRVRFTTAPDLVNELKEARADGRL-ERLLKRLAKVDLLILDELGYLPLDAEGA 179

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15831529 183 VTLNQIVDRRtASMRSVGMLTNLNHAAMSTLLGDRVM-----DRMTMNgGRWVNFNWESWR 238
Cdd:COG1484 180 ELLFELISDR-YERRSTIITSNLPFSEWGEVFGDPTLatailDRLVHH-AHIIELKGESYR 238
PRK08116 PRK08116
hypothetical protein; Validated
 37-223 3.72e-21

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 89.31  E-value: 3.72e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   37 AEGRKRSEEINRlNHQVRVEKILNRAGIQPLHRKCSFGNYRVQNdGQRHALSQAKSIAD---ELMTGCTNFVFSGKPGTG 113
Cdd:PRK08116  49 AEEAKEREEENR-EKQRRIERLKSNSLLDEKFRNSTFENFLFDK-GSEKAYKIARKYVKkfeEMKKENVGLLLWGSVGTG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  114 KNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGY-DNGQSGE-KFLQELCGVDLLVLDEIGMQRDTRNEQVTLNQIVDR 191
Cdd:PRK08116 127 KTYLAACIANELIEKGVPVIFVNFPQLLNRIKSTYkSSGKEDEnEIIRSLVNADLLILDDLGAERDTEWAREKVYNIIDS 206

                        170       180       190
                 ....*....|....*....|....*....|..
gi 15831529  192 RTASMRSVGMLTNLNHAAMSTLLGDRVMDRMT 223
Cdd:PRK08116 207 RYRKGLPTIVTTNLSLEELKNQYGKRIYDRIL 238
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 95-238 6.84e-20

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 84.83  E-value: 6.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   95 DELMTG-----CTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGqSGEKFLQELCGVDLLVL 169
Cdd:NF038214  79 RELATLdfierAENVLLLGPPGTGKTHLAIALGYAACRQGYRVRFTTAADLVEQLAQARADG-RLGRLLRRLARYDLLII 157

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15831529  170 DEIGMQRDTRNEQVTLNQIVDRR--TASMrsvgMLT-NLNHAAMSTLLGDRVM-----DRMTMNgGRWVNFNWESWR 238
Cdd:NF038214 158 DELGYLPFSREGANLLFELIADRyeRGST----IITsNLPFSEWGEVFGDPTLaaailDRLVHH-AHILELKGESYR 229
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 30-238 9.97e-16

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 74.02  E-value: 9.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    30 EWREWQLAEGRKRSEEINRLNHQVRVEKIlnragiqPLHRKCSFGNYRVQNDGQRHALSQAKSIAdeLMTGCTNFVFSGK 109
Cdd:pfam01695  30 EEFLEHLLEEELAWRDTRRLERLLRMAKL-------PPHKTLEDFDFTFAPGLDQRIVAELASLS--FIDRAQNVVLLGP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   110 PGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKfLQELCGVDLLVLDEIGMQRDTRNEQVTLNQIV 189
Cdd:pfam01695 101 PGVGKTHLAIALGVEACRAGYSVRFTSAADLVNQLKRAHGDGKLTRK-LQQLLKPDVLILDEWGYLPLDQAEANLLFQVI 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15831529   190 DRRTASmRSVGMLTNLNHAAMSTLLGDRVM-----DRMTMNGGRwVNFNWESWR 238
Cdd:pfam01695 180 SKRYEH-RSIILTSNLPFGEWGQVFGDAVLatailDRLLHHCHI-VPIKGESYR 231
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 101-225 5.48e-15

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 73.01  E-value: 5.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  101 CTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDG-YDNGQSGEKFLQELCGVDLLVLDEIGmqrdtr 179
Cdd:PRK06835 183 NENLLFYGNTGTGKTFLSNCIAKELLDRGKSVIYRTADELIEILREIrFNNDKELEEVYDLLINCDLLIIDDLG------ 256

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15831529  180 NEQVT------LNQIVDRRTASMRSVGMLTNLNHAAMSTLLGDRVMDRMTMN 225
Cdd:PRK06835 257 TEKITefskseLFNLINKRLLRQKKMIISTNLSLEELLKTYSERISSRLLGN 308
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 82-193 2.96e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 57.16  E-value: 2.96e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  82 GQRHALSQAKSIADELMTGctNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKFLQEL 161
Cdd:cd00009   2 GQEEAIEALREALELPPPK--NLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFEL 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15831529 162 ---CGVDLLVLDEIG-MQRDTRNEQV-TLNQIVDRRT 193
Cdd:cd00009  80 aekAKPGVLFIDEIDsLSRGAQNALLrVLETLNDLRI 116
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
67-172 1.20e-08

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 54.43  E-value: 1.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  67 LHRKCSFGNYrVQNDGQRHALSQAKSIADELMTGcTNFVF-SGKPGTGKNHLAAAIGNRLMAK--GRSVIIVTVSDVMSV 143
Cdd:COG0593   1 LNPRYTFDNF-VVGPSNRLAHAAALAVAEWPGKA-YNPLFlYGGVGLGKTHLLHAIGNEALENnpGARVVYLTAEEFTND 78

                        90       100
                ....*....|....*....|....*....
gi 15831529 144 LHDGYDNGqSGEKFLQELCGVDLLVLDEI 172
Cdd:COG0593  79 FINAIRNN-TIEEFKEKYRSVDVLLIDDI 106
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 103-222 7.04e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.45  E-value: 7.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    103 NFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKFLQ--------------ELCGVDLLV 168
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASgsgelrlrlalalaRKLKPDVLI 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 15831529    169 LDEIGMQRDTRNEQVTLNQIVDRRTASMRSVG-----MLTNLNHAAMSTLLGDRVMDRM 222
Cdd:smart00382  84 LDEITSLLDAEQEALLLLLEELRLLLLLKSEKnltviLTTNDEKDLGPALLRRRFDRRI 142
PRK09183 PRK09183
transposase/IS protein; Provisional
 103-196 1.21e-06

transposase/IS protein; Provisional


Pssm-ID: 181681  Cd Length: 259  Bit Score: 48.16  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  103 NFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKFLQELCGVDLLVLDEIGMQRDTRNEQ 182
Cdd:PRK09183 104 NIVLLGPSGVGKTHLAIALGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQRGVMAPRLLIIDEIGYLPFSQEEA 183

                         90
                 ....*....|....*.
gi 15831529  183 VTLNQIVDRR--TASM 196
Cdd:PRK09183 184 NLFFQVIAKRyeKGSM 199
PRK06526 PRK06526
transposase; Provisional
 96-173 1.29e-06

transposase; Provisional


Pssm-ID: 180607  Cd Length: 254  Bit Score: 47.94  E-value: 1.29e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15831529   96 ELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSgEKFLQELCGVDLLVLDEIG 173
Cdd:PRK06526  93 DFVTGKENVVFLGPPGTGKTHLAIGLGIRACQAGHRVLFATAAQWVARLAAAHHAGRL-QAELVKLGRYPLLIVDEVG 169
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 56-172 1.33e-06

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 48.68  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    56 EKILNRAGIQPLHRKCSFGNYrVQNDGQRHALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAK--GRSVI 133
Cdd:TIGR00362  93 EAPAPPSSASGLNPKYTFDNF-VVGKSNRLAHAAALAVAENPGKAYNPLFIYGGVGLGKTHLLHAIGNEILENnpNAKVL 171

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 15831529   134 IVTVSDVMSVLHDGYDNGQSgEKFLQELCGVDLLVLDEI 172
Cdd:TIGR00362 172 YVSSEKFTNDFVNALRNNKM-EEFKEKYRSVDLLLIDDI 209
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 106-173 1.43e-06

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 48.33  E-value: 1.43e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15831529  106 FSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSGEKfLQELCGVDLLVLDEIG 173
Cdd:PRK08939 161 LYGDFGVGKSYLLAAIANELAKKGVSSTLLHFPEFIRELKNSISDGSVKEK-IDAVKEAPVLMLDDIG 227
PRK08181 PRK08181
transposase; Validated
 10-238 2.18e-06

transposase; Validated


Pssm-ID: 136670 [Multi-domain]  Cd Length: 269  Bit Score: 47.62  E-value: 2.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   10 LERIRRLAPQGAV-------PPYRTVEEWREWQLAEGRKRseeinrlnhqvRVEKILNRAGIQPLHRKCSFGNYRVQndg 82
Cdd:PRK08181  21 LPTIKTLWPQFAEqadkegwPAARFLAAIAEHELAERARR-----------RIERHLAEAHLPPGKTLDSFDFEAVP--- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   83 qrhALSQAKSIA----DELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVMSVLHDGYDNGQSgEKFL 158
Cdd:PRK08181  87 ---MVSKAQVMAiaagDSWLAKGANLLLFGPPGGGKSHLAAAIGLALIENGWRVLFTRTTDLVQKLQVARRELQL-ESAI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  159 QELCGVDLLVLDEIGMQRDTRNEQVTLNQIVDRRTaSMRSVGMLTN---------LNHAAMSTLLGDRVMDRMTMnggrw 229
Cdd:PRK08181 163 AKLDKFDLLILDDLAYVTKDQAETSVLFELISARY-ERRSILITANqpfgewnrvFPDPAMTLAAVDRLVHHATI----- 236


                 ....*....
gi 15831529  230 VNFNWESWR 238
Cdd:PRK08181 237 FEMNVESYR 245
PRK06921 PRK06921
hypothetical protein; Provisional
 52-172 4.74e-06

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 46.31  E-value: 4.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   52 QVRVEKILNRAGIQPLHRKCSFGNYRVQNDGQ--RHALSQAKSIAD--ELMTGCTN--FVFSGKPGTGKNHLAAAIGNRL 125
Cdd:PRK06921  62 QRKIERLLKASEITEAFRKLTFKNFKTEGKPQaiKDAYECAVEYVKdfEKIQESRKnsIALLGQPGSGKTHLLTAAANEL 141

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 15831529  126 MAK-GRSVIIVTVSDVMSVLHDGYDNgqsGEKFLQELCGVDLLVLDEI 172
Cdd:PRK06921 142 MRKkGVPVLYFPFVEGFGDLKDDFDL---LEAKLNRMKKVEVLFIDDL 186
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 103-189 5.14e-05

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 42.27  E-value: 5.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529 103 NFVFSGKPGTGKNHLAAAIGNRLmakGRSVIIVTVSDVMSV-LHDGYDNGQSGEKFLQELCGVdLLVLDEI---GMQRDT 178
Cdd:cd19481  28 GILLYGPPGTGKTLLAKALAGEL---GLPLIVVKLSSLLSKyVGESEKNLRKIFERARRLAPC-ILFIDEIdaiGRKRDS 103

                        90
                ....*....|.
gi 15831529 179 RNEQVTLNQIV 189
Cdd:cd19481 104 SGESGELRRVL 114
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 54-142 1.42e-04

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 42.59  E-value: 1.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  54 RVEKILNRAGIQPLHRKCSFgnyrvqndgQRHALSQAKSIadelmtgctnfVFSGKPGTGKNHLAAAIGNRLmakGRSVI 133
Cdd:COG0464 164 EVKEELRELVALPLKRPELR---------EEYGLPPPRGL-----------LLYGPPGTGKTLLARALAGEL---GLPLI 220


                ....*....
gi 15831529 134 IVTVSDVMS 142
Cdd:COG0464 221 EVDLSDLVS 229
RecD COG0507
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 80-174 2.25e-04

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 41.89  E-value: 2.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  80 NDGQRHALsqaksiaDELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVT----VSDVM------------SV 143
Cdd:COG0507 126 SDEQREAV-------ALALTTRRVSVLTGGAGTGKTTTLRALLAALEALGLRVALAAptgkAAKRLsestgieartihRL 198

                        90       100       110
                ....*....|....*....|....*....|.
gi 15831529 144 LHDGYDNGQSGEKFLQELCGVDLLVLDEIGM 174
Cdd:COG0507 199 LGLRPDSGRFRHNRDNPLTPADLLVVDEASM 229
dnaA PRK00149
chromosomal replication initiator protein DnaA;
73-172 2.35e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 41.66  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   73 FGNYrVQNDGQRHALSQAKSIADELmtGCT-NFVF-SGKPGTGKNHLAAAIGNRLMAK--GRSVIIVT----VSDVMSVL 144
Cdd:PRK00149  72 FDNF-VVGKSNRLAHAAALAVAENP--GKAyNPLFiYGGVGLGKTHLLHAIGNYILEKnpNAKVVYVTsekfTNDFVNAL 148

                         90       100
                 ....*....|....*....|....*...
gi 15831529  145 HDGydngqSGEKFLQELCGVDLLVLDEI 172
Cdd:PRK00149 149 RNN-----TMEEFKEKYRSVDVLLIDDI 171
Bac_DnaA pfam00308
Bacterial dnaA protein;
67-172 3.50e-04

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 40.77  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529    67 LHRKCSFGNYrVQNDGQRHALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAKGRS--VIIVTVSDVMSVL 144
Cdd:pfam00308   1 LNPRYTFENF-VIGPSNRFAHAAALTVAKAPGKAYNPLFIYGGVGLGKTHLLHAIGNYALQNAPNlrVVYLTAEEFLNDF 79

                          90       100
                  ....*....|....*....|....*...
gi 15831529   145 HDGYDNGQsGEKFLQELCGVDLLVLDEI 172
Cdd:pfam00308  80 VDAIRDNK-TNQFKEKYRNVDVLLIDDI 106
SIMIBI cd01983
SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal ...
 104-169 5.41e-04

SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal recognition particle, MinD, and BioD), consists of signal recognition particle (SRP) GTPases, the assemblage of MinD-like ATPases, which are involved in protein localization, chromosome partitioning, and membrane transport, and a group of metabolic enzymes with kinase or related phosphate transferase activity. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349751 [Multi-domain]  Cd Length: 107  Bit Score: 38.57  E-value: 5.41e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15831529 104 FVFSGKPGTGKNHLAAAIGNRLMAKGRSVIIVTVSDVmsVLhdgYDNGQSGEKFLQELCGVDLLVL 169
Cdd:cd01983   4 AVTGGKGGVGKTTLAAALAVALAAKGYKVLLIDLDDY--VL---IDGGGGLETGLLLGTIVALLAL 64
DEXSc_RecD-like cd17933
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ...
 82-174 1.15e-03

DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350691 [Multi-domain]  Cd Length: 155  Bit Score: 38.30  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529  82 GQRHALsqaksiadELMTGCTNFVFSGKPGTGKNHLAAAIGNRLMAKGRSVII----------------VTVSDVMSVLh 145
Cdd:cd17933   1 EQKAAV--------RLVLRNRVSVLTGGAGTGKTTTLKALLAALEAEGKRVVLaaptgkaakrlsestgIEASTIHRLL- 71

                        90       100       110
                ....*....|....*....|....*....|
gi 15831529 146 dGYDNGQSGEKFLQELC-GVDLLVLDEIGM 174
Cdd:cd17933  72 -GINPGGGGFYYNEENPlDADLLIVDEASM 100
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 82-172 3.30e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 38.14  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831529   82 GQRHALSQAKSI-----ADELmtgcTNFVFSGKPGTGKNHLAAAIGNRLMAKGR--SVIIVTVSDVMSVLHDGYDNGQSG 154
Cdd:PRK13342  16 GQEHLLGPGKPLrrmieAGRL----SSMILWGPPGTGKTTLARIIAGATDAPFEalSAVTSGVKDLREVIEEARQRRSAG 91

                         90
                 ....*....|....*...
gi 15831529  155 EKFlqelcgvdLLVLDEI 172
Cdd:PRK13342  92 RRT--------ILFIDEI 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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