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Conserved domains on  [gi|15832124|ref|NP_310897|]
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transcriptional regulator [Escherichia coli O157:H7 str. Sakai]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10009472)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
1-96 2.66e-38

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


:

Pssm-ID: 444337  Cd Length: 105  Bit Score: 123.45  E-value: 2.66e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832124   1 MKIETFDSVWDAVSDTPEQAENMRIRAELVTIINNWIEQQGFSQAQAASALGVTQPRISELARGKIQIFSIDKLITMMAH 80
Cdd:COG5606   5 EIEESSGNVFADLGFPDEEAEELKLKAQLMAAIRKLIKERGLTQAEAAELLGITQPRVSDLLRGKISKFSLDKLVNMLAR 84

                        90
                ....*....|....*.
gi 15832124  81 AGLHIQrIEVQYPHAA 96
Cdd:COG5606  85 LGQDVE-IVVRPARAA 99
 
Name Accession Description Interval E-value
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
1-96 2.66e-38

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


Pssm-ID: 444337  Cd Length: 105  Bit Score: 123.45  E-value: 2.66e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832124   1 MKIETFDSVWDAVSDTPEQAENMRIRAELVTIINNWIEQQGFSQAQAASALGVTQPRISELARGKIQIFSIDKLITMMAH 80
Cdd:COG5606   5 EIEESSGNVFADLGFPDEEAEELKLKAQLMAAIRKLIKERGLTQAEAAELLGITQPRVSDLLRGKISKFSLDKLVNMLAR 84

                        90
                ....*....|....*.
gi 15832124  81 AGLHIQrIEVQYPHAA 96
Cdd:COG5606  85 LGQDVE-IVVRPARAA 99
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 17-91 1.01e-17

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 70.72  E-value: 1.01e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15832124   17 PEQAENMRIRAELVTIINNWIEQQGFSQAQAASALGVTQPRISELARGKIQIFSIDKLITMMAHAGLHIQrIEVQ 91
Cdd:pfam13744  7 FEDAEELQAKAQLARAIARLIEGRGLSQQEAAALLGIAQPKVSALLKGKLSRFSLDKLLDFLTALGQDVE-IVVK 80
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
38-77 3.75e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 37.88  E-value: 3.75e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15832124    38 EQQGFSQAQAASALGVTQPRISELARGKIQIfSIDKLITM 77
Cdd:smart00530  7 EEKGLTQEELAEKLGVSRSTLSRIENGKRKP-SLETLKKL 45
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 32-75 1.14e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 36.76  E-value: 1.14e-04
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....
gi 15832124 32 IINNWIEQQGFSQAQAASALGVTQPRISELARGKIQIfSIDKLI 75
Cdd:cd00093  3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNP-SLETLE 45
 
Name Accession Description Interval E-value
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
1-96 2.66e-38

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


Pssm-ID: 444337  Cd Length: 105  Bit Score: 123.45  E-value: 2.66e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832124   1 MKIETFDSVWDAVSDTPEQAENMRIRAELVTIINNWIEQQGFSQAQAASALGVTQPRISELARGKIQIFSIDKLITMMAH 80
Cdd:COG5606   5 EIEESSGNVFADLGFPDEEAEELKLKAQLMAAIRKLIKERGLTQAEAAELLGITQPRVSDLLRGKISKFSLDKLVNMLAR 84

                        90
                ....*....|....*.
gi 15832124  81 AGLHIQrIEVQYPHAA 96
Cdd:COG5606  85 LGQDVE-IVVRPARAA 99
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 17-91 1.01e-17

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 70.72  E-value: 1.01e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15832124   17 PEQAENMRIRAELVTIINNWIEQQGFSQAQAASALGVTQPRISELARGKIQIFSIDKLITMMAHAGLHIQrIEVQ 91
Cdd:pfam13744  7 FEDAEELQAKAQLARAIARLIEGRGLSQQEAAALLGIAQPKVSALLKGKLSRFSLDKLLDFLTALGQDVE-IVVK 80
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
38-77 3.75e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 37.88  E-value: 3.75e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15832124    38 EQQGFSQAQAASALGVTQPRISELARGKIQIfSIDKLITM 77
Cdd:smart00530  7 EEKGLTQEELAEKLGVSRSTLSRIENGKRKP-SLETLKKL 45
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 32-75 1.14e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 36.76  E-value: 1.14e-04
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....
gi 15832124 32 IINNWIEQQGFSQAQAASALGVTQPRISELARGKIQIfSIDKLI 75
Cdd:cd00093  3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNP-SLETLE 45
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 38-83 1.29e-04

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 36.74  E-value: 1.29e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 15832124   38 EQQGFSQAQAASALGVTQPRISELARGKIQIFSIDKLITMMAHAGL 83
Cdd:pfam13560 11 ERAGLSQEALARRLGVSRSTLSRLETGRRGRPSPAVVERLARALGV 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 38-88 1.50e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 36.36  E-value: 1.50e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15832124   38 EQQGFSQAQAASALGVTQPRISELARGKIQIfSIDKLITMMAHAGLHIQRI 88
Cdd:pfam01381  6 EELGLSQEELAEKLGVSRSTISKIENGKREP-SLETLKKLAEALGVSLDEL 55
AF0184 COG2522
Predicted transcriptional regulator, contains XRE-type HTH domain [Transcription];
25-65 5.95e-04

Predicted transcriptional regulator, contains XRE-type HTH domain [Transcription];


Pssm-ID: 442012 [Multi-domain]  Cd Length: 99  Bit Score: 35.57  E-value: 5.95e-04
                       10        20        30        40
               ....*....|....*....|....*....|....*....|.
gi 15832124 25 IRAELVTIINNwieqQGFSQAQAASALGVTQPRISELARGK 65
Cdd:COG2522 16 IRALLAKELVE----RGLSQSEIAKLLGITQAAVSQYLSGK 52
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 37-68 1.21e-03

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 34.78  E-value: 1.21e-03
                       10        20        30
               ....*....|....*....|....*....|..
gi 15832124 37 IEQQGFSQAQAASALGVTQPRISELARGKIQI 68
Cdd:COG3093 18 LEPLGLSQTELAKALGVSRQRISEILNGKRAI 49
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
24-75 3.30e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 33.43  E-value: 3.30e-03
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|..
gi 15832124 24 RIRAELVTIINNWIEQQGFSQAQAASALGVTQPRISELARGKIQIfSIDKLI 75
Cdd:COG1396  3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNP-SLETLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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