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Conserved domains on  [gi|15832494|ref|NP_311267|]
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resolvase [Escherichia coli O157:H7 str. Sakai]

Protein Classification

recombinase family protein( domain architecture ID 10132949)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0000150|GO:0003677|GO:0006310|GO:0015074
PubMed:  21645851|26104451|11972771|16077726|9348666
SCOP:  3000065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 3-148 4.46e-76

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


:

Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 225.28  E-value: 4.46e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   3 VRIYCRASTEGQHADRALTSLREFSKSKGWQIAGEYIENASGAKLERVELMRLLSEAQSGDLLLVEAIDRLSRLEHSAWV 82
Cdd:cd03767   1 IRAYLRASTDEQDATRAKESLEAFATERGFYIAGFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRLPLDDWE 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832494  83 ELKDTLNRKGLIIVSMDLPTSWQMVEMAGNDLTSGILRAVNAMLIDILATMARQDYETRRKRQQQG 148
Cdd:cd03767  81 TLKASIAAKGLRVVSLDLPTSHSALAAEDNDFTGRILSAINDMLLDLLAAMARKDYEDRRERQKQG 146
 
Name Accession Description Interval E-value
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 3-148 4.46e-76

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 225.28  E-value: 4.46e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   3 VRIYCRASTEGQHADRALTSLREFSKSKGWQIAGEYIENASGAKLERVELMRLLSEAQSGDLLLVEAIDRLSRLEHSAWV 82
Cdd:cd03767   1 IRAYLRASTDEQDATRAKESLEAFATERGFYIAGFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRLPLDDWE 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832494  83 ELKDTLNRKGLIIVSMDLPTSWQMVEMAGNDLTSGILRAVNAMLIDILATMARQDYETRRKRQQQG 148
Cdd:cd03767  81 TLKASIAAKGLRVVSLDLPTSHSALAAEDNDFTGRILSAINDMLLDLLAAMARKDYEDRRERQKQG 146
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-206 3.61e-28

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 108.96  E-value: 3.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   1 MNVRIYCRASTEGQHA---DRALTSLREFSKSKGWQIAGEYIENA-SGAKLERVELMRLLSEAQSG--DLLLVEAIDRLS 74
Cdd:COG1961   2 MRAAGYARVSTDDQEGlslERQREALRAYAEKAGWEIVRIYVDEGvSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494  75 R-LEHsaWVELKDTLNRKGLIIVSMDLPTswqmvemagnDLTSgilrAVNAMLIDILATMARQDYETRRKRQQQGIERAK 153
Cdd:COG1961  82 RnLAD--LLELVEELKERGVRLISLTEGI----------DTST----PMGRLLLTILAAFAEFERELISERTRAGLAAAK 145

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15832494 154 SEGIYIGRAK-----------NQEAREIVR---EMLEQGVKPELIMK---AAGI---SRATYYRIKNELLIVK 206
Cdd:COG1961 146 ARGKYLGRPPygyrdpkklviDEEEAEVVRrifELYLEGKSLREIARelnERGIptwSRSTVYRILKNPVYGG 218
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 3-158 1.15e-26

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 99.62  E-value: 1.15e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494      3 VRIYCRASTEGQHA---DRALTSLREFSKSKGWQIAGEYIENA-SGAKLERVELMRLLSEAQSGD--LLLVEAIDRLSRL 76
Cdd:smart00857   1 AAGYARVSTDDQADgslERQLEALRAYAERNGWEVVRIYEDEGvSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494     77 EhSAWVELKDTLNRKGLIIVSmdlptswqmVEMAGNDLTSgilrAVNAMLIDILATMARQDYETRRKRQQQGIERAKSEG 156
Cdd:smart00857  81 L-RDLLALLELLEEKGVRLVS---------LKEGILDTST----PAGRLLLDILAALAEFERELISERTKAGLARAAARG 146


                   ..
gi 15832494    157 IY 158
Cdd:smart00857 147 RW 148
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 5-158 8.73e-16

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 71.15  E-value: 8.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494     5 IYCRASTEGQHA--DRALTSLREFSKSKGwqIAGEYIE-NASGAKLERVELMRLLSEAQS--GDLLLVEAIDRLSRlEHS 79
Cdd:pfam00239   3 GYARVSTEDQDDslERQLEALRAYAACNG--KIVEFEDkGVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGR-SLR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15832494    80 AWVELKDTLNRKGLIIVSMDLPTswqmvemagnDLTSGILRavnaMLIDILATMARQDYETRRKRQQQGIERAKSEGIY 158
Cdd:pfam00239  80 DLLTLVEELREKGVDLVSLDEGI----------DTSTPMGR----LLLTILAALAEFERALIRERTRAGLAAAAARGKL 144
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
6-197 2.38e-07

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 49.33  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494    6 YCRASTEGQHADRALTSLREFSKSKGWQIAGEYIENASGAK-LERVELMRLLSEAQSGDLLLVEAIDRLSRLEHSAWVEL 84
Cdd:PRK13413   5 YIRVSTDKQTVENQRFEITNFAEKNNLTIDKWIEETISGTKsYKDRKLGKLLKKMRKGDILIVSELSRLGRNLMEIMSIL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   85 KDTLNRKglIIVsmdlptsWQMVE--MAGNDLTSGILravnAMLIDILATMARQDYETRRKrqqQGIERAKSEGIYIGRA 162
Cdd:PRK13413  85 NICMEKE--VIV-------YTIKEgyELGDDINSKVL----AFAFGLSAEIERNLISQRTK---EALARKKAEGVTLGRP 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 15832494  163 KNQEA--------REIVREMLEQGVKPELIMKAAGISRATYYR 197
Cdd:PRK13413 149 KGSTPkkykltgkEEKIKKLLDKGTSKSEIARKLGVSRTTLAR 191
 
Name Accession Description Interval E-value
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 3-148 4.46e-76

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 225.28  E-value: 4.46e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   3 VRIYCRASTEGQHADRALTSLREFSKSKGWQIAGEYIENASGAKLERVELMRLLSEAQSGDLLLVEAIDRLSRLEHSAWV 82
Cdd:cd03767   1 IRAYLRASTDEQDATRAKESLEAFATERGFYIAGFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRLPLDDWE 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832494  83 ELKDTLNRKGLIIVSMDLPTSWQMVEMAGNDLTSGILRAVNAMLIDILATMARQDYETRRKRQQQG 148
Cdd:cd03767  81 TLKASIAAKGLRVVSLDLPTSHSALAAEDNDFTGRILSAINDMLLDLLAAMARKDYEDRRERQKQG 146
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-206 3.61e-28

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 108.96  E-value: 3.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   1 MNVRIYCRASTEGQHA---DRALTSLREFSKSKGWQIAGEYIENA-SGAKLERVELMRLLSEAQSG--DLLLVEAIDRLS 74
Cdd:COG1961   2 MRAAGYARVSTDDQEGlslERQREALRAYAEKAGWEIVRIYVDEGvSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494  75 R-LEHsaWVELKDTLNRKGLIIVSMDLPTswqmvemagnDLTSgilrAVNAMLIDILATMARQDYETRRKRQQQGIERAK 153
Cdd:COG1961  82 RnLAD--LLELVEELKERGVRLISLTEGI----------DTST----PMGRLLLTILAAFAEFERELISERTRAGLAAAK 145

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15832494 154 SEGIYIGRAK-----------NQEAREIVR---EMLEQGVKPELIMK---AAGI---SRATYYRIKNELLIVK 206
Cdd:COG1961 146 ARGKYLGRPPygyrdpkklviDEEEAEVVRrifELYLEGKSLREIARelnERGIptwSRSTVYRILKNPVYGG 218
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 3-158 1.15e-26

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 99.62  E-value: 1.15e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494      3 VRIYCRASTEGQHA---DRALTSLREFSKSKGWQIAGEYIENA-SGAKLERVELMRLLSEAQSGD--LLLVEAIDRLSRL 76
Cdd:smart00857   1 AAGYARVSTDDQADgslERQLEALRAYAERNGWEVVRIYEDEGvSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494     77 EhSAWVELKDTLNRKGLIIVSmdlptswqmVEMAGNDLTSgilrAVNAMLIDILATMARQDYETRRKRQQQGIERAKSEG 156
Cdd:smart00857  81 L-RDLLALLELLEEKGVRLVS---------LKEGILDTST----PAGRLLLDILAALAEFERELISERTKAGLARAAARG 146


                   ..
gi 15832494    157 IY 158
Cdd:smart00857 147 RW 148
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 5-148 5.88e-17

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 73.67  E-value: 5.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   5 IYCRASTEGQHADRALTSLREFSKSKGWqiageYIENASGAKLERVELMRLLSEAQSGDLLLVEAIDRLSR-LEHSawVE 83
Cdd:cd03768   3 GYARVSTDDQSLERQLEALKAAGECDKI-----FEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRsTKDL--LE 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15832494  84 LKDTLNRKGLIIVSMDLPTswqmvemagnDLTSGILRavnaMLIDILATMARQDYETRRKRQQQG 148
Cdd:cd03768  76 IVEELREKGVSLRSLTEGI----------DTSTPSGK----LMLTILGAFAEFERELIRERTKEG 126
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 5-148 6.71e-17

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 73.83  E-value: 6.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   5 IYCRASTEGQHADRALTS----LREFSKSKGWQIAGEYIENASGAK--LERVELMRLLSEAQSG--DLLLVEAIDRLSRl 76
Cdd:cd00338   1 IYARVSTDKQEQGDSLERqreaLREYAARNGLEVVGEYEDAGSSATslVDRPGLQRLLADVKAGkiDVVLVEKLDRLSR- 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15832494  77 EHSAWVELKDTLNRKGLIIVSMDLPTswqmvemagnDLTSgilrAVNAMLIDILATMARQDYETRRKRQQQG 148
Cdd:cd00338  80 NLVDLLELLELLEAHGVRVVTADGEI----------DLDS----EDGRLMLGILAAMAEEESKLISERTKRG 137
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 5-158 8.73e-16

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 71.15  E-value: 8.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494     5 IYCRASTEGQHA--DRALTSLREFSKSKGwqIAGEYIE-NASGAKLERVELMRLLSEAQS--GDLLLVEAIDRLSRlEHS 79
Cdd:pfam00239   3 GYARVSTEDQDDslERQLEALRAYAACNG--KIVEFEDkGVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGR-SLR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15832494    80 AWVELKDTLNRKGLIIVSMDLPTswqmvemagnDLTSGILRavnaMLIDILATMARQDYETRRKRQQQGIERAKSEGIY 158
Cdd:pfam00239  80 DLLTLVEELREKGVDLVSLDEGI----------DTSTPMGR----LLLTILAALAEFERALIRERTRAGLAAAAARGKL 144
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
6-197 2.38e-07

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 49.33  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494    6 YCRASTEGQHADRALTSLREFSKSKGWQIAGEYIENASGAK-LERVELMRLLSEAQSGDLLLVEAIDRLSRLEHSAWVEL 84
Cdd:PRK13413   5 YIRVSTDKQTVENQRFEITNFAEKNNLTIDKWIEETISGTKsYKDRKLGKLLKKMRKGDILIVSELSRLGRNLMEIMSIL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   85 KDTLNRKglIIVsmdlptsWQMVE--MAGNDLTSGILravnAMLIDILATMARQDYETRRKrqqQGIERAKSEGIYIGRA 162
Cdd:PRK13413  85 NICMEKE--VIV-------YTIKEgyELGDDINSKVL----AFAFGLSAEIERNLISQRTK---EALARKKAEGVTLGRP 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 15832494  163 KNQEA--------REIVREMLEQGVKPELIMKAAGISRATYYR 197
Cdd:PRK13413 149 KGSTPkkykltgkEEKIKKLLDKGTSKSEIARKLGVSRTTLAR 191
SR_TndX_transposase cd03770
Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of ...
 3-75 4.62e-04

Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. TndX mediates the excision and circularization of the conjugative transposon Tn5397 from Clostridium difficile. TnpX is responsible for the movement of the nonconjugative chloramphenicol resistance elements of the Tn4451/3 family. Mobile genetic elements such as transposons are important vehicles for the transmission of virulence and antibiotic resistance in many microorganisms.


Pssm-ID: 239739 [Multi-domain]  Cd Length: 140  Bit Score: 38.89  E-value: 4.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832494   3 VRIYCRAST--EGQHADRALTS----LREFSKSKGWQIAGEYI-ENASGAKLERVELMRLLSEAQSG--DLLLVEAIDRL 73
Cdd:cd03770   1 TALYCRLSRddDLDGESNSIENqkaiLEEYAKENGLENIRHYIdDGFSGTTFDRPGFNRMIEDIEAGkiDIVIVKDMSRL 80


                ..
gi 15832494  74 SR 75
Cdd:cd03770  81 GR 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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