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Conserved domains on  [gi|15832801|ref|NP_311574|]
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multidrug efflux system protein [Escherichia coli O157:H7 str. Sakai]

Protein Classification

multidrug efflux MFS transporter periplasmic adaptor subunit EmrA( domain architecture ID 11487672)

multidrug efflux MFS transporter periplasmic adaptor subunit EmrA is part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15136 PRK15136
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
1-390 0e+00

multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;


:

Pssm-ID: 185090 [Multi-domain]  Cd Length: 390  Bit Score: 768.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801    1 MSANAETQTPQQPVKKSGKRKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNT 80
Cdd:PRK15136   1 MSANAETQTPQQPVKKKGKRKRALLLLTLLFIIIGVAYGIYWFLVLRHHQETDDAYVAGNQVQIMSQVSGSVTKVWADNT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   81 DFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTHQQMINSKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREEL 160
Cdd:PRK15136  81 DFVKEGDVLVTLDPTDAEQAFEKAKTALANSVRQTHQLMINSKQYQANIELQKTALAQAQSDLNRRVPLGNANLIGREEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  161 QHARDAVTSAQAQLDVAIQQYNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT 240
Cdd:PRK15136 161 QHARDAVASAQAQLDVAIQQYNANQAMILNTPLEDQPAVQQAATEVRNAWLALQRTKIVSPMTGYVSRRSVQVGAQISPT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  241 TPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP 320
Cdd:PRK15136 241 TPLMAVVPATNLWVDANFKETQLANMRIGQPATITSDIYGDDVVYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  321 VRIELDQKQLEQYPLRIGLSTLVSVNTTNRDGQVLANKVRSTPVAVSTAREISLAPVNKLIDDIVKANAG 390
Cdd:PRK15136 321 VRIELDAKQLAQHPLRIGLSTLVTVDTANRDGQVLANQVRSTPAYESNALEIDLAPVNKLIDDIIQANAG 390
 
Name Accession Description Interval E-value
PRK15136 PRK15136
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
1-390 0e+00

multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;


Pssm-ID: 185090 [Multi-domain]  Cd Length: 390  Bit Score: 768.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801    1 MSANAETQTPQQPVKKSGKRKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNT 80
Cdd:PRK15136   1 MSANAETQTPQQPVKKKGKRKRALLLLTLLFIIIGVAYGIYWFLVLRHHQETDDAYVAGNQVQIMSQVSGSVTKVWADNT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   81 DFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTHQQMINSKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREEL 160
Cdd:PRK15136  81 DFVKEGDVLVTLDPTDAEQAFEKAKTALANSVRQTHQLMINSKQYQANIELQKTALAQAQSDLNRRVPLGNANLIGREEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  161 QHARDAVTSAQAQLDVAIQQYNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT 240
Cdd:PRK15136 161 QHARDAVASAQAQLDVAIQQYNANQAMILNTPLEDQPAVQQAATEVRNAWLALQRTKIVSPMTGYVSRRSVQVGAQISPT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  241 TPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP 320
Cdd:PRK15136 241 TPLMAVVPATNLWVDANFKETQLANMRIGQPATITSDIYGDDVVYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  321 VRIELDQKQLEQYPLRIGLSTLVSVNTTNRDGQVLANKVRSTPVAVSTAREISLAPVNKLIDDIVKANAG 390
Cdd:PRK15136 321 VRIELDAKQLAQHPLRIGLSTLVTVDTANRDGQVLANQVRSTPAYESNALEIDLAPVNKLIDDIIQANAG 390
8a0101 TIGR00998
efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, ...
 20-345 4.35e-172

efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, Other]


Pssm-ID: 273385 [Multi-domain]  Cd Length: 334  Bit Score: 483.14  E-value: 4.35e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801    20 RKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQ 99
Cdd:TIGR00998   1 RKYFLLLLVVLLIVVAGAYAIYWFLVLRDYESTDDAYVKANQLQVSSQVSGSVIEVNVDDTDYVKQGDVLVRLDPTNAEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   100 AFEKAKTALASSVRQTHQQMINSKQLQANIEVQKIALAKAQS-------DYNRRVPLGNANLIGREELQHARDAVTSAQA 172
Cdd:TIGR00998  81 ALAKAEANLAALVRQTKQLEITVQQLQAKVESLKIKLEQAREkllqaelDLRRRVPLFKKGLISREELDHARKALLSAKA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   173 QLDVAIQ-QYNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATN 251
Cdd:TIGR00998 161 ALNAAIQeQLNANQALVRGTPLKKQPAVQEAKERLKTAWLALKRTVIRAPFDGYVARRFVQVGQVVSPGQPLMAVVPAEQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   252 MWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDQKQLE 331
Cdd:TIGR00998 241 MYVEANFKETQLKNVRIGQPVTIRSDLYGSDVVFEGKVTGISMGTGSAFSLLPAQNATGNWIKVVQRLPVRIKLDPKELD 320

                         330
                  ....*....|....
gi 15832801   332 QYPLRIGLSTLVSV 345
Cdd:TIGR00998 321 EHPLRIGLSAEVEI 334
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
31-347 2.17e-77

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 242.26  E-value: 2.17e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  31 FIIIAVAIGIYWFLVLRHF---EETDDAYVAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTA 107
Cdd:COG1566  12 LVLLLLALGLALWAAGRNGpdePVTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQAEAQ 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801 108 LASSVRQTHQQMINS------KQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREELQHARDAVTSAQAQLDVAIQQY 181
Cdd:COG1566  92 LAAAEAQLARLEAELgaeaeiAAAEAQLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAAQAQLEAAQAQL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801 182 NANQAMILG--TKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFK 259
Cdd:COG1566 172 AQAQAGLREeeELAAAQAQVAQAEAALAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLTIVPLDDLWVEAYVP 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801 260 ETQIANMRIGQPVTITTDIYgDDVKYTGKVVGLDMGTGSAFsllPAQNATGNwikVVQRLPVRIELDQKQLEqyPLRIGL 339
Cdd:COG1566 252 ETDLGRVKPGQPVEVRVDAY-PDRVFEGKVTSISPGAGFTS---PPKNATGN---VVQRYPVRIRLDNPDPE--PLRPGM 322


                ....*...
gi 15832801 340 STLVSVNT 347
Cdd:COG1566 323 SATVEIDT 330
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 47-347 2.39e-61

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 200.34  E-value: 2.39e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801    47 RHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTHQQMINSKQLQ 126
Cdd:pfam00529   6 KGVEAPGRVVVSGNAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELDRLQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   127 ------------------------ANIEVQKIALAKAQSDYNRRVPLGNANLIGREELQHARDAVTSAQAQLDVAIQQ-- 180
Cdd:pfam00529  86 aleselaisrqdydgataqlraaqAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVAQld 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   181 ---------YNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQP-GAQISPTTPLMAVVPAT 250
Cdd:pfam00529 166 qiyvqitqsAAENQAEVRSELSGAQLQIAEAEAELKLAKLDLERTEIRAPVDGTVAFLSVTVdGGTVSAGLRLMFVVPED 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   251 NMWVDANFKETQIANMRIGQPVTITTDIYGDDV--KYTGKVVGLDMGTGsafsllpaqnatgnwikvvqrlPVRIELDQK 328
Cdd:pfam00529 246 NLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKtgRFTGVVVGISPDTG----------------------PVRVVVDKA 303

                         330
                  ....*....|....*....
gi 15832801   329 QLEQYPLRIGLSTLVSVNT 347
Cdd:pfam00529 304 QGPYYPLRIGLSAGALVRL 322
 
Name Accession Description Interval E-value
PRK15136 PRK15136
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
1-390 0e+00

multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;


Pssm-ID: 185090 [Multi-domain]  Cd Length: 390  Bit Score: 768.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801    1 MSANAETQTPQQPVKKSGKRKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNT 80
Cdd:PRK15136   1 MSANAETQTPQQPVKKKGKRKRALLLLTLLFIIIGVAYGIYWFLVLRHHQETDDAYVAGNQVQIMSQVSGSVTKVWADNT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   81 DFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTHQQMINSKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREEL 160
Cdd:PRK15136  81 DFVKEGDVLVTLDPTDAEQAFEKAKTALANSVRQTHQLMINSKQYQANIELQKTALAQAQSDLNRRVPLGNANLIGREEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  161 QHARDAVTSAQAQLDVAIQQYNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT 240
Cdd:PRK15136 161 QHARDAVASAQAQLDVAIQQYNANQAMILNTPLEDQPAVQQAATEVRNAWLALQRTKIVSPMTGYVSRRSVQVGAQISPT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  241 TPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP 320
Cdd:PRK15136 241 TPLMAVVPATNLWVDANFKETQLANMRIGQPATITSDIYGDDVVYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  321 VRIELDQKQLEQYPLRIGLSTLVSVNTTNRDGQVLANKVRSTPVAVSTAREISLAPVNKLIDDIVKANAG 390
Cdd:PRK15136 321 VRIELDAKQLAQHPLRIGLSTLVTVDTANRDGQVLANQVRSTPAYESNALEIDLAPVNKLIDDIIQANAG 390
8a0101 TIGR00998
efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, ...
 20-345 4.35e-172

efflux pump membrane protein (multidrug resistance protein A); [Transport and binding proteins, Other]


Pssm-ID: 273385 [Multi-domain]  Cd Length: 334  Bit Score: 483.14  E-value: 4.35e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801    20 RKRLLLLLTLLFIIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQ 99
Cdd:TIGR00998   1 RKYFLLLLVVLLIVVAGAYAIYWFLVLRDYESTDDAYVKANQLQVSSQVSGSVIEVNVDDTDYVKQGDVLVRLDPTNAEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   100 AFEKAKTALASSVRQTHQQMINSKQLQANIEVQKIALAKAQS-------DYNRRVPLGNANLIGREELQHARDAVTSAQA 172
Cdd:TIGR00998  81 ALAKAEANLAALVRQTKQLEITVQQLQAKVESLKIKLEQAREkllqaelDLRRRVPLFKKGLISREELDHARKALLSAKA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   173 QLDVAIQ-QYNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATN 251
Cdd:TIGR00998 161 ALNAAIQeQLNANQALVRGTPLKKQPAVQEAKERLKTAWLALKRTVIRAPFDGYVARRFVQVGQVVSPGQPLMAVVPAEQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   252 MWVDANFKETQIANMRIGQPVTITTDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDQKQLE 331
Cdd:TIGR00998 241 MYVEANFKETQLKNVRIGQPVTIRSDLYGSDVVFEGKVTGISMGTGSAFSLLPAQNATGNWIKVVQRLPVRIKLDPKELD 320

                         330
                  ....*....|....
gi 15832801   332 QYPLRIGLSTLVSV 345
Cdd:TIGR00998 321 EHPLRIGLSAEVEI 334
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
31-347 2.17e-77

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 242.26  E-value: 2.17e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  31 FIIIAVAIGIYWFLVLRHF---EETDDAYVAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTA 107
Cdd:COG1566  12 LVLLLLALGLALWAAGRNGpdePVTADGRVEARVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQAEAQ 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801 108 LASSVRQTHQQMINS------KQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREELQHARDAVTSAQAQLDVAIQQY 181
Cdd:COG1566  92 LAAAEAQLARLEAELgaeaeiAAAEAQLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAAQAQLEAAQAQL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801 182 NANQAMILG--TKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFK 259
Cdd:COG1566 172 AQAQAGLREeeELAAAQAQVAQAEAALAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLTIVPLDDLWVEAYVP 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801 260 ETQIANMRIGQPVTITTDIYgDDVKYTGKVVGLDMGTGSAFsllPAQNATGNwikVVQRLPVRIELDQKQLEqyPLRIGL 339
Cdd:COG1566 252 ETDLGRVKPGQPVEVRVDAY-PDRVFEGKVTSISPGAGFTS---PPKNATGN---VVQRYPVRIRLDNPDPE--PLRPGM 322


                ....*...
gi 15832801 340 STLVSVNT 347
Cdd:COG1566 323 SATVEIDT 330
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 47-347 2.39e-61

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 200.34  E-value: 2.39e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801    47 RHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALASSVRQTHQQMINSKQLQ 126
Cdd:pfam00529   6 KGVEAPGRVVVSGNAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELDRLQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   127 ------------------------ANIEVQKIALAKAQSDYNRRVPLGNANLIGREELQHARDAVTSAQAQLDVAIQQ-- 180
Cdd:pfam00529  86 aleselaisrqdydgataqlraaqAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVAQld 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   181 ---------YNANQAMILGTKLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQP-GAQISPTTPLMAVVPAT 250
Cdd:pfam00529 166 qiyvqitqsAAENQAEVRSELSGAQLQIAEAEAELKLAKLDLERTEIRAPVDGTVAFLSVTVdGGTVSAGLRLMFVVPED 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   251 NMWVDANFKETQIANMRIGQPVTITTDIYGDDV--KYTGKVVGLDMGTGsafsllpaqnatgnwikvvqrlPVRIELDQK 328
Cdd:pfam00529 246 NLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKtgRFTGVVVGISPDTG----------------------PVRVVVDKA 303

                         330
                  ....*....|....*....
gi 15832801   329 QLEQYPLRIGLSTLVSVNT 347
Cdd:pfam00529 304 QGPYYPLRIGLSAGALVRL 322
PRK10476 PRK10476
multidrug transporter subunit MdtN;
32-345 3.37e-33

multidrug transporter subunit MdtN;


Pssm-ID: 182488 [Multi-domain]  Cd Length: 346  Bit Score: 126.68  E-value: 3.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   32 IIIAVAIGIYWFLVLRHFEETDDAYVAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALASS 111
Cdd:PRK10476  19 VALAIVALVFVIWRTDSAPSTDDAYIDADVVHVASEVGGRIVELAVTENQAVKKGDLLFRIDPRPYELTVAQAQADLALA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  112 VRQ--THQQMINSKQLQANIEVQKIALAKAQSD-----YNRRVPLGNANLIGREELQHARDAVTSAQAQLDVAIQQYNAN 184
Cdd:PRK10476  99 DAQimTTQRSVDAERSNAASANEQVERARANAKlatrtLERLEPLLAKGYVSAQQVDQARTAQRDAEVSLNQALLQAQAA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  185 QAMILGTK-LEDQPAVQQAATEVrnAWLALERTRIVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFKETQI 263
Cdd:PRK10476 179 AAAVGGVDaLVAQRAAREAALAI--AELHLEDTTVRAPFDGRVVGLKVSVGEFAAPMQPIFTLIDTDHWYAIANFRETDL 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  264 ANMRIGQPVTITTDIygDDVK-YTGKVVGLDMGTGSAFSL-----LPAQNATGNWIKVVQRLPVRIELDQKQLEQypLRI 337
Cdd:PRK10476 257 KNIRVGDCATVYSMI--DRGRpFEGKVDSIGWGVLPDDGGnvprgLPYVPRSINWVRVAQRFPVRIMLDKPDPEL--FRI 332


                 ....*...
gi 15832801  338 GLSTLVSV 345
Cdd:PRK10476 333 GASAVVEL 340
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 57-355 3.75e-33

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 126.21  E-value: 3.75e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  57 VAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAktalassvrqthqqminskqlQANIEVQKIAL 136
Cdd:COG0845  19 EARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQA---------------------QAQLAAAQAQL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801 137 AKAQSDYNRRVPLGNANLIGREELQHARDAVTSAQAQldvaiqqynanqamilgtkledqpaVQQAATEVRNAWLALERT 216
Cdd:COG0845  78 ELAKAELERYKALLKKGAVSQQELDQAKAALDQAQAA-------------------------LAAAQAALEQARANLAYT 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801 217 RIVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYgDDVKYTGKVVGLDmgt 296
Cdd:COG0845 133 TIRAPFDGVVGERNVEPGQLVSAGTPLFTIADLDPLEVEFDVPESDLARLKVGQPVTVTLDAG-PGKTFEGKVTFID--- 208

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15832801 297 gsafsllPAQNATgnwikvVQRLPVRIELDQKQLeqyPLRIGLSTLVSVNTTNRDGQVL 355
Cdd:COG0845 209 -------PAVDPA------TRTVRVRAELPNPDG---LLRPGMFVRVRIVLGERENALL 251
PRK03598 PRK03598
putative efflux pump membrane fusion protein; Provisional
 20-289 1.64e-20

putative efflux pump membrane fusion protein; Provisional


Pssm-ID: 235136 [Multi-domain]  Cd Length: 331  Bit Score: 91.18  E-value: 1.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   20 RKRLLLLLTLLFIIIAVAIGIYWFLvlrhfEETDDA-YVAGN----QIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDP 94
Cdd:PRK03598   2 KKKVVIGLAVVVLAAAVAGGWWWYQ-----SRQDNGlTLYGNvdirTVNLGFRVGGRLASLAVDEGDAVKAGQVLGELDA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   95 TDARQAFEKAKTALASS-------VRQTHQQMInsKQLQANIEVQKIALAKAQSDYNRRVPLGNANLIGREELQHARDAV 167
Cdd:PRK03598  77 APYENALMQAKANVSVAqaqldlmLAGYRDEEI--AQARAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  168 TSAQAQLDVAIQQYNANQAmilGTKLED----QPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPTTPL 243
Cdd:PRK03598 155 DQAQATLKSAQDKLSQYRE---GNRPQDiaqaKASLAQAQAALAQAELNLQDTELIAPSDGTILTRAVEPGTMLNAGSTV 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 15832801  244 MAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVkYTGKV 289
Cdd:PRK03598 232 FTLSLTRPVWVRAYVDERNLGQAQPGRKVLLYTDGRPDKP-YHGQI 276
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 57-289 5.59e-20

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 89.68  E-value: 5.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801    57 VAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKtalassvrqthqqminskqlqANIEVQKIAL 136
Cdd:TIGR01730  22 EAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAAL---------------------AQLAAAEAQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   137 AKAQSDYNRRVPLgnanligreelqHARDAVTsaQAQLDVAIQQYNANQAmilgtkledqpAVQQAATEVRNAWLALERT 216
Cdd:TIGR01730  81 ELAQRSFERAERL------------VKRNAVS--QADLDDAKAAVEAAQA-----------DLEAAKASLASAQLNLRYT 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15832801   217 RIVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYgDDVKYTGKV 289
Cdd:TIGR01730 136 EIRAPFDGTIGRRLVEVGAYVTAGQTLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDAL-PGEEFKGKL 207
PRK10559 PRK10559
p-hydroxybenzoic acid efflux pump subunit AaeA;
52-334 1.15e-16

p-hydroxybenzoic acid efflux pump subunit AaeA;


Pssm-ID: 182548 [Multi-domain]  Cd Length: 310  Bit Score: 79.78  E-value: 1.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   52 TDDAYVAGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALAssvrqTHQQMINSKQLQANiev 131
Cdd:PRK10559  38 TRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQPRYQKALAEAEADVA-----YYQVLAQEKRREAG--- 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  132 qkialakaqsdynRRVPLGnANLIGREELQHARDAVTSAQAQLdvaiqqynanqamilgtkledqpAVQQAATEVrnAWL 211
Cdd:PRK10559 110 -------------RRNRLG-VQAMSREEIDQANNVLQTVLHQL-----------------------AKAQATRDL--AKL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  212 ALERTRIVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTdiYGDDVKYTGKVVG 291
Cdd:PRK10559 151 DLERTVIRAPADGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITP--LGSNKVLKGTVDS 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 15832801  292 LDMGTGSAFSL-----LPAQNATGNWIKVVQRLPVRIELDQKQLEQYP 334
Cdd:PRK10559 229 VAAGVTNSSSTrdskgMATIDSNLEWVRLAQRVPVRIRLDNQQGNLYP 276
HlyD_D23 pfam16576
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ...
 212-289 3.93e-10

Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.


Pssm-ID: 435440 [Multi-domain]  Cd Length: 214  Bit Score: 59.06  E-value: 3.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   212 ALERTR-------IVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDIYGDDVk 284
Cdd:pfam16576  98 ELERTGkvqptvtVYAPISGVVTELNVREGMYVQPGDTLFTIADLSTVWVEADVPEQDLALVKVGQPAEVTLPALPGKT- 176


                  ....*
gi 15832801   285 YTGKV 289
Cdd:pfam16576 177 FEGKV 181
type_I_hlyD TIGR01843
type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport ...
 31-340 4.43e-10

type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130902 [Multi-domain]  Cd Length: 423  Bit Score: 60.79  E-value: 4.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801    31 FIIIAVAIGIYWFLVLRHFEETDDAYVA-------GNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQA--- 100
Cdd:TIGR01843   6 LITWLIAGLVVIFFLWAYFAPLDVVATAtgkvvpsGNVKVVQHLEGGIVREILVREGDRVKAGQVLVELDATDVEADaae 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   101 -------------------------------------------------FEKAKTALASSVRQTHQQMinsKQLQANIEV 131
Cdd:TIGR01843  86 lesqvlrleaevarlraeadsqaaiefpddllsaedpavpelikgqqslFESRKSTLRAQLELILAQI---KQLEAELAG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   132 QKIALAKAQSD---YNRRV----PLGNANLIGREELQHARDAVTSAQAQLDVAIQQYNANQAMILGTKLEDQPAVQQAAT 204
Cdd:TIGR01843 163 LQAQLQALRQQlevISEELearrKLKEKGLVSRLELLELERERAEAQGELGRLEAELEVLKRQIDELQLERQQIEQTFRE 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   205 EVRN------------------AWLALERTRIVSPMTGYVSRRAVQP-GAQISPTTPLMAVVPATN-MWVDANFKETQIA 264
Cdd:TIGR01843 243 EVLEelteaqarlaelrerlnkARDRLQRLIIRSPVDGTVQSLKVHTvGGVVQPGETLMEIVPEDDpLEIEAKLSPKDIG 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15832801   265 NMRIGQPVTITTDIYgDDVKY---TGKVVGLdmgtgSAfSLLPAQNATGNWikvvqrLPVRIELDQKQLEQYPLRIGLS 340
Cdd:TIGR01843 323 FVHVGQPAEIKFSAF-PYRRYgilNGKVKSI-----SP-DTFTDERGGGPY------YRVRISIDQNTLGIGPKGLELS 388
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
 217-338 9.35e-08

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 49.67  E-value: 9.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   217 RIVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFKETQIANMRIGQPVTITTDiYGDDVKYTGKVVgldmgt 296
Cdd:pfam13437   1 TIRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLKKGQKVTLKLD-PGSDYTLEGKVV------ 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 15832801   297 gsafSLLPAQNATGnwikvvQRLPVRIELDQkQLEQYPLRIG 338
Cdd:pfam13437  74 ----RISPTVDPDT------GVIPVRVSIEN-PKTPIPLLPG 104
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
 66-289 1.66e-06

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 49.77  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   66 SQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALassvrqthqqminsKQLQANIEVQKIALAKAQSDYNR 145
Cdd:PRK11578  66 AQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAENQIKEVEATL--------------MELRAQRQQAEAELKLARVTLSR 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  146 RVPLGNANLIGREELQHARDAVTSAQAQLDVAIQQYNANQAmilgtkledqpavqqaatEVRNAWLALERTRIVSPMTGY 225
Cdd:PRK11578 132 QQRLAKTQAVSQQDLDTAATELAVKQAQIGTIDAQIKRNQA------------------SLDTAKTNLDYTRIVAPMAGE 193

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  226 VSRRAVQPG-----AQISPTtpLMAVVPATNMWVDANFKETQIANMRIGQPVTITtdIYGD-DVKYTGKV 289
Cdd:PRK11578 194 VTQITTLQGqtviaAQQAPN--ILTLADMSTMLVKAQVSEADVIHLKPGQKAWFT--VLGDpLTRYEGVL 259
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
58-274 1.38e-05

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 46.71  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   58 AGNQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALASSvrqthqqminskqlqanievqKIALA 137
Cdd:PRK11556  84 AANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKD---------------------QATLA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  138 KAQSDYNRRVPLGNANLIGREELQHARDAVTSAQAQLDVaiqqynanqamilgtkleDQPAVQqaatevrNAWLALERTR 217
Cdd:PRK11556 143 NARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIKA------------------DEASVA-------SAQLQLDYSR 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15832801  218 IVSPMTGYVSRRAVQPGAQISPTTPLMAVVPATNMWVDANFK--ETQIANM----RIGQPVTI 274
Cdd:PRK11556 198 ITAPISGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTlpESDIATVvqaqKAGKPLVV 260
PRK09859 PRK09859
multidrug transporter subunit MdtE;
63-238 1.83e-05

multidrug transporter subunit MdtE;


Pssm-ID: 137559 [Multi-domain]  Cd Length: 385  Bit Score: 46.25  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801   63 QIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALASSVRqthqqminskqlqanievqkiALAKAQSD 142
Cdd:PRK09859  63 EIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALS---------------------TASNARIT 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832801  143 YNRRVPLGNANLIGREELQHARDAVTSAQAQLDVAiqqynanqamilgtkledQPAVQQAAtevrnawLALERTRIVSPM 222
Cdd:PRK09859 122 FNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVA------------------KAAVEQAT-------INLQYANVTSPI 176

                        170
                 ....*....|....*.
gi 15832801  223 TGYVSRRAVQPGAQIS 238
Cdd:PRK09859 177 TGVSGKSSVTVGALVT 192
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
60-109 2.32e-04

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 38.58  E-value: 2.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 15832801    60 NQIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLDPTDARQAFEKAKTALA 109
Cdd:pfam13533   1 PVVKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEAQLA 50
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 61-93 8.65e-03

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 34.76  E-value: 8.65e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 15832801   61 QIQIMSQVSGSVTKVWADNTDFVKEGDVLVTLD 93
Cdd:PRK08225  38 EIPIVAEEAGTVKKINVQEGDFVNEGDVLLEIE 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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