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Conserved domains on  [gi|15832830|ref|NP_311603|]
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formate hydrogenlyase complex iron-sulfur protein [Escherichia coli O157:H7 str. Sakai]

Protein Classification

formate hydrogenlyase complex iron-sulfur subunit( domain architecture ID 11485882)

formate hydrogenlyase complex iron-sulfur subunit is a 4Fe-4S dicluster domain-containing protein that may function as an electron transfer protein for the hydrogenase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 1-180 1.24e-121

formate hydrogenlyase complex iron-sulfur subunit; Provisional


:

Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 340.47  E-value: 1.24e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830    1 MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80
Cdd:PRK12387   1 MFKLIKKVIKTGTATSSYPLEPIAVDKNFRGKPEYNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   81 CEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKR 160
Cdd:PRK12387  81 CEEVCPTAAIKLSQEFELAVWKKEDLLQQSEFALCNCRVCGRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKR 160

                        170       180
                 ....*....|....*....|
gi 15832830  161 QKCLVPSDRIELTRHMKEAI 180
Cdd:PRK12387 161 QKCLVPSDRIELTRHMKEAI 180
 
Name Accession Description Interval E-value
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 1-180 1.24e-121

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 340.47  E-value: 1.24e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830    1 MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80
Cdd:PRK12387   1 MFKLIKKVIKTGTATSSYPLEPIAVDKNFRGKPEYNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   81 CEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKR 160
Cdd:PRK12387  81 CEEVCPTAAIKLSQEFELAVWKKEDLLQQSEFALCNCRVCGRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKR 160

                        170       180
                 ....*....|....*....|
gi 15832830  161 QKCLVPSDRIELTRHMKEAI 180
Cdd:PRK12387 161 QKCLVPSDRIELTRHMKEAI 180
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 33-173 1.51e-22

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 87.45  E-value: 1.51e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  33 PEQNPQQCIGCAACVNACPSNALTVETDLATGELaWEFNLGRCIFCGRCEEVCPTAAIKLSQEY-ELAVWKKEDFLQQSR 111
Cdd:cd10549   1 LKYDPEKCIGCGICVKACPTDAIELGPNGAIARG-PEIDEDKCVFCGACVEVCPTGAIELTPEGkEYVPKEKEAEIDEEK 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15832830 112 faLCNCRVCNRPFAVQkeidyAIALlkhngdSRAENHRESFETCPECKR--QKClvPSDRIELT 173
Cdd:cd10549  80 --CIGCGLCVKVCPVD-----AITL------EDELEIVIDKEKCIGCGIcaEVC--PVNAIKLV 128
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 15-106 2.57e-20

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 81.31  E-value: 2.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830    15 TSSYPLEPIAVDKNFRG-----KPEQNPQQCIGCAACVNACPSNALTVET----DLATGELAWEFNLGRCIFCGRCEEVC 85
Cdd:TIGR01971  15 TVQYPEEKLYLPPRFRGrivltRDPNGEEKCIGCTLCAAVCPADAIRVVPaegeDGKRRLKFYEINFGRCIFCGLCEEAC 94

                          90       100
                  ....*....|....*....|.
gi 15832830    86 PTAAIKLSQEYELAVWKKEDF 106
Cdd:TIGR01971  95 PTDAIVLTPEFELATYTRSDL 115
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 37-105 1.78e-17

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 72.47  E-value: 1.78e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15832830  37 PQQCIGCAACVNACPSNALTVETDlaTGELAWEFNLGRCIFCGRCEEVCPTAAIKLSQeYELAVWKKED 105
Cdd:COG1143   1 EDKCIGCGLCVRVCPVDAITIEDG--EPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 40-89 3.94e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 55.61  E-value: 3.94e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15832830    40 CIGCAACVNACPSNALTV-ETDLATGELAWEFNLGRCIFCGRCEEVCPTAA 89
Cdd:pfam12838   1 CIGCGACVAACPVGAITLdEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 40-90 7.86e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 41.77  E-value: 7.86e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15832830   40 CIGCAACVNACPSNALTVEtdlaTGELAWEfnlGRCIFCGRCEEVCPTAAI 90
Cdd:NF038196 187 CIGCGICAKVCPVNNIEME----DGKPVWG---HNCTHCLACIHRCPKEAI 230
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 74-104 7.35e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 35.99  E-value: 7.35e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 15832830   74 RCIFCGRCEEVCPTAAIKLSQEYelAVWKKE 104
Cdd:NF038196 186 KCIGCGICAKVCPVNNIEMEDGK--PVWGHN 214
 
Name Accession Description Interval E-value
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 1-180 1.24e-121

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 340.47  E-value: 1.24e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830    1 MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80
Cdd:PRK12387   1 MFKLIKKVIKTGTATSSYPLEPIAVDKNFRGKPEYNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   81 CEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKR 160
Cdd:PRK12387  81 CEEVCPTAAIKLSQEFELAVWKKEDLLQQSEFALCNCRVCGRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKR 160

                        170       180
                 ....*....|....*....|
gi 15832830  161 QKCLVPSDRIELTRHMKEAI 180
Cdd:PRK12387 161 QKCLVPSDRIELTRHMKEAI 180
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 1-179 1.29e-69

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 209.22  E-value: 1.29e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830    1 MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80
Cdd:PRK08222   1 MLKLLKTIMRAGTATVKYPFAPLEVSPGFRGKPDLMPSQCIACGACTCACPANALTIQTDDQQNSRTWQLYLGRCIYCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   81 CEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLKH--NGDSRAENHRESFETCPEC 158
Cdd:PRK08222  81 CEEVCPTRAIQLTNNFELTVTNKADLYTRATFHLQRCSRCERPFAPQKTVALAAELLAQqqNAPQNREMLRAQASVCPEC 160

                        170       180
                 ....*....|....*....|.
gi 15832830  159 KRQKCLVpSDRIELTRHMKEA 179
Cdd:PRK08222 161 KQRATLI-NDDTDVPLVAKEQ 180
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 33-173 1.51e-22

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 87.45  E-value: 1.51e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  33 PEQNPQQCIGCAACVNACPSNALTVETDLATGELaWEFNLGRCIFCGRCEEVCPTAAIKLSQEY-ELAVWKKEDFLQQSR 111
Cdd:cd10549   1 LKYDPEKCIGCGICVKACPTDAIELGPNGAIARG-PEIDEDKCVFCGACVEVCPTGAIELTPEGkEYVPKEKEAEIDEEK 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15832830 112 faLCNCRVCNRPFAVQkeidyAIALlkhngdSRAENHRESFETCPECKR--QKClvPSDRIELT 173
Cdd:cd10549  80 --CIGCGLCVKVCPVD-----AITL------EDELEIVIDKEKCIGCGIcaEVC--PVNAIKLV 128
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
3-107 1.03e-21

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 86.09  E-value: 1.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830    3 TFIKKVIktgtaTSSYPLEPIAVDKNFRG-----KPEQNPQQCIGCAACVNACPSNALTVETDLAT-GELAWEF---NLG 73
Cdd:PRK05888  23 YFFKKKV-----TIQYPEEKLPLSPRFRGrhalrRDPNGEERCIACKLCAAICPADAITIEAAEREdGRRRTTRydiNFG 97

                         90       100       110
                 ....*....|....*....|....*....|....
gi 15832830   74 RCIFCGRCEEVCPTAAIKLSQEYELAVWKKEDFL 107
Cdd:PRK05888  98 RCIFCGFCEEACPTDAIVETPDFELATETREELI 131
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 15-106 2.57e-20

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 81.31  E-value: 2.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830    15 TSSYPLEPIAVDKNFRG-----KPEQNPQQCIGCAACVNACPSNALTVET----DLATGELAWEFNLGRCIFCGRCEEVC 85
Cdd:TIGR01971  15 TVQYPEEKLYLPPRFRGrivltRDPNGEEKCIGCTLCAAVCPADAIRVVPaegeDGKRRLKFYEINFGRCIFCGLCEEAC 94

                          90       100
                  ....*....|....*....|.
gi 15832830    86 PTAAIKLSQEYELAVWKKEDF 106
Cdd:TIGR01971  95 PTDAIVLTPEFELATYTRSDL 115
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 37-105 1.78e-17

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 72.47  E-value: 1.78e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15832830  37 PQQCIGCAACVNACPSNALTVETDlaTGELAWEFNLGRCIFCGRCEEVCPTAAIKLSQeYELAVWKKED 105
Cdd:COG1143   1 EDKCIGCGLCVRVCPVDAITIEDG--EPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 1-105 2.78e-17

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 73.72  E-value: 2.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830    1 MFTFIKKVIKTGT---ATSSYP-LEPIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATGELaWefnLGRCI 76
Cdd:PRK08348   1 RLPLLPTVLRNLFkkpATNLFPaTEPVPVPEDFRGKILYDVDKCVGCRMCVTVCPAGVFVYLPEIRKVAL-W---TGRCV 76

                         90       100
                 ....*....|....*....|....*....
gi 15832830   77 FCGRCEEVCPTAAIKLSQEYELAVWKKED 105
Cdd:PRK08348  77 FCGQCVDVCPTGALQMSDDFLLASYDRFD 105
ndhI TIGR00403
NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]
 15-106 2.85e-15

NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]


Pssm-ID: 129498 [Multi-domain]  Cd Length: 183  Bit Score: 69.94  E-value: 2.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830    15 TSSYPLEPIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTV----ETDLATGELA-WEFNLGRCIFCGRCEEVCPTAA 89
Cdd:TIGR00403  39 TIQYPYEKLIPSERFRGRIHFEFDKCIACEVCVRVCPINLPVVdwefNKAIKKKQLKnYSIDFGVCIFCGNCVEYCPTNC 118

                          90
                  ....*....|....*..
gi 15832830    90 IKLSQEYELAVWKKEDF 106
Cdd:TIGR00403 119 LSMTEEYELSTYDRHEL 135
ndhI CHL00014
NADH dehydrogenase subunit I
 15-101 6.02e-15

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 68.63  E-value: 6.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   15 TSSYPLEPIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATG-----ELAWEFNLGRCIFCGRCEEVCPTAA 89
Cdd:CHL00014  36 TIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDirkkrLLNYSIDFGVCIFCGNCVEYCPTNC 115

                         90
                 ....*....|..
gi 15832830   90 IKLSQEYELAVW 101
Cdd:CHL00014 116 LSMTEEYELSTY 127
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
31-103 4.23e-13

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 61.29  E-value: 4.23e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15832830  31 GKPEQNPQQCIGCAACVNACPSNALTVETDlatgelAWEFNLGRCIFCGRCEEVCPTAAIKLSQEYELAVWKK 103
Cdd:COG2768   4 GKPYVDEEKCIGCGACVKVCPVGAISIEDG------KAVIDPEKCIGCGACIEVCPVGAIKIEWEEDEEFQEK 70
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 32-94 1.19e-11

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 57.37  E-value: 1.19e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15832830  32 KPEQNPQQCIGCAACVNACPSNALTVETDLAtgelawEFNLGRCIFCGRCEEVCPTAAIKLSQ 94
Cdd:COG2221   9 PPKIDEEKCIGCGLCVAVCPTGAISLDDGKL------VIDEEKCIGCGACIRVCPTGAIKGEK 65
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 40-89 3.94e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 55.61  E-value: 3.94e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15832830    40 CIGCAACVNACPSNALTV-ETDLATGELAWEFNLGRCIFCGRCEEVCPTAA 89
Cdd:pfam12838   1 CIGCGACVAACPVGAITLdEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 36-100 7.33e-11

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 55.10  E-value: 7.33e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15832830  36 NPQQCIGCAACVNACPSNALTVETDlatGELAWEFNLGRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:COG1146   6 DTDKCIGCGACVEVCPVDVLELDEE---GKKALVINPEECIGCGACELVCPVGAITVEDDEPEEQ 67
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 30-92 2.12e-10

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 53.96  E-value: 2.12e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15832830  30 RGKPEQNPQQCIGCAACVNACPSNALTVEtdlatGELAWEFNLGRCIFCGRCEEVCPTAAIKL 92
Cdd:COG1149   3 RKIPVIDEEKCIGCGLCVEVCPEGAIKLD-----DGGAPVVDPDLCTGCGACVGVCPTGAITL 60
NapF COG1145
Ferredoxin [Energy production and conversion];
32-92 2.00e-09

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 55.11  E-value: 2.00e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15832830  32 KPEQNPQQCIGCAACVNACPSNALTvetdLATGELAWEFNLGRCIFCGRCEEVCPTAAIKL 92
Cdd:COG1145 176 KAVIDAEKCIGCGLCVKVCPTGAIR----LKDGKPQIVVDPDKCIGCGACVKVCPVGAISL 232
PRK13984 PRK13984
putative oxidoreductase; Provisional
 29-107 3.59e-09

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 54.77  E-value: 3.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   29 FRGKPEQNPQQCIGCAACVNACPSNALT-VET-DLAT--GELAWE--FNLGRCIFCGRCEEVCPTAAIKLSQEYELAVWK 102
Cdd:PRK13984  36 YRGFHINDWEKCIGCGTCSKICPTDAITmVEVpDLPQeyGKKPQRpvIDYGRCSFCALCVDICTTGSLKMTREYIHISPD 115


                 ....*
gi 15832830  103 KEDFL 107
Cdd:PRK13984 116 PEDFI 120
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
36-93 5.26e-09

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 53.91  E-value: 5.26e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15832830  36 NPQQCIGCAACVNACPsnaltVETDLATGELawefNLGRCIFCGRCEEVCPTAAIKLS 93
Cdd:COG0348 208 DRGDCIDCGLCVKVCP-----MGIDIRKGEI----NQSECINCGRCIDACPKDAIRFS 256
PRK13795 PRK13795
hypothetical protein; Provisional
 40-91 6.27e-09

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 54.23  E-value: 6.27e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15832830   40 CIGCAACVNACPSNALTVETDLATGELAWEfnlgRCIFCGRCEEVCPTAAIK 91
Cdd:PRK13795 583 CVGCGVCVGACPTGAIRIEEGKRKISVDEE----KCIHCGKCTEVCPVVKYK 630
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 32-97 8.77e-09

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 50.05  E-value: 8.77e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832830  32 KPEQNPQQCIGCAACVNACPSNALTVETDLATGelaweFNLGRCIFCGRCEEVCPTAAIKLSQEYE 97
Cdd:COG1144  24 RPVVDEDKCIGCGLCWIVCPDGAIRVDDGKYYG-----IDYDYCKGCGICAEVCPVKAIEMVPEEK 84
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
22-91 1.49e-08

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 53.11  E-value: 1.49e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  22 PIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLAtgelawEFNLGRCIFCGRCEEVCPTAAIK 91
Cdd:COG4624  75 GIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVDDGKA------EIDEEKCISCGQCVAVCPFGAIT 138
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 36-95 1.70e-08

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 49.27  E-value: 1.70e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  36 NPQQCIGCAACVNACPSNALTVETDLAtgelawEFNLGRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:COG4231  20 DEDKCTGCGACVKVCPADAIEEGDGKA------VIDPDLCIGCGSCVQVCPVDAIKLEKR 73
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
36-100 2.02e-08

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 50.43  E-value: 2.02e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15832830  36 NPQQCIGC--AACVNACPSNALTVETDlatgelAWEFNLGRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:COG1142  48 APVQCRHCedAPCAEVCPVGAITRDDG------AVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAV 108
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 32-86 2.39e-08

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 48.40  E-value: 2.39e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15832830    32 KPEQNPQQCIGCAACVNACPSNALTV-ETDLATGELAWEFNLGRCIFCGRCEEVCP 86
Cdd:pfam13237   1 KVVIDPDKCIGCGRCTAACPAGLTRVgAIVERLEGEAVRIGVWKCIGCGACVEACP 56
RnfC COG4656
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and ...
 33-104 3.10e-08

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443694 [Multi-domain]  Cd Length: 451  Bit Score: 52.06  E-value: 3.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  33 PEQNPQQCIGCAACVNACPSNaltvetdLATGELAW-----------EFNLGRCIFCGRCEEVCPtAAIKLSQEYELAvw 101
Cdd:COG4656 359 PPPEEQPCIRCGRCVDACPMG-------LLPQQLYWyaragdfdkaeEYNLMDCIECGCCSYVCP-SKIPLVQYIRLA-- 428


                ...
gi 15832830 102 KKE 104
Cdd:COG4656 429 KAE 431
rnfC TIGR01945
electron transport complex, RnfABCDGE type, C subunit; The six subunit complex RnfABCDGE in ...
 33-99 3.19e-08

electron transport complex, RnfABCDGE type, C subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the C subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273888 [Multi-domain]  Cd Length: 435  Bit Score: 51.96  E-value: 3.19e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15832830    33 PEQNPQQCIGCAACVNACPSNALTVETD-LATG---ELAWEFNLGRCIFCGRCEEVCPtAAIKLSQEYELA 99
Cdd:TIGR01945 358 PESPEKPCIRCGKCVQVCPMNLLPQQLNwLALAdefDEAEEHNLMDCIECGCCSYVCP-SNIPLVQYIRQA 427
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
40-90 6.85e-08

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 50.70  E-value: 6.85e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15832830   40 CIGCAACVNACPSNALTVETDLAtgelawEFNLGRCIFCGRCEEVCPTAAI 90
Cdd:PRK07118 215 CIGCGKCVKACPAGAITMENNLA------VIDQEKCTSCGKCVEKCPTKAI 259
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
33-92 2.17e-07

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 49.86  E-value: 2.17e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  33 PEQNPQQCIGCAACVNACPSNALTVETDLATgelawEFNLGRCIFCGRCEEVCPTAAIKL 92
Cdd:COG1148 491 AEVDPEKCTGCGRCVEVCPYGAISIDEKGVA-----EVNPALCKGCGTCAAACPSGAISL 545
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 38-95 3.61e-07

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 47.24  E-value: 3.61e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15832830  38 QQCIGCAACVNACPSNALTV------ETDLATGElawefnlgrCIFCGRCEEVCPTAAIKLSQE 95
Cdd:cd10564  13 DLCTRCGDCVEACPEGIIVRgdggfpELDFSRGE---------CTFCGACAEACPEGALDPARE 67
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 33-113 4.28e-07

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 48.79  E-value: 4.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   33 PEQNPQQCIGCAACVNACPSnaltvetDLATGELAW-----------EFNLGRCIFCGRCEEVCPtAAIKLSQEYELA-- 99
Cdd:PRK05035 365 PPPPEQPCIRCGACADACPA-------SLLPQQLYWfakaeehdkaqEYNLFDCIECGACAYVCP-SNIPLVQYYRQAka 436

                         90
                 ....*....|....*
gi 15832830  100 -VWKKEDFLQQSRFA 113
Cdd:PRK05035 437 eIRAIEQEKKKAEEA 451
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 20-95 4.32e-07

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 48.72  E-value: 4.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   20 LEPIAVDKNF----RGKPEQNPQQ----------CIGCAACVNACPSNALTvetDLATGeLAWEFNLGRCIFCGRCEEVC 85
Cdd:PRK12771 478 LDADERVGDFdevlGGLTEEEARQeaarclscgnCFECDNCYGACPQDAII---KLGPG-RRYHFDYDKCTGCHICADVC 553

                         90
                 ....*....|
gi 15832830   86 PTAAIKLSQE 95
Cdd:PRK12771 554 PCGAIEMGPG 563
PRK09898 PRK09898
ferredoxin-like protein;
38-92 4.40e-07

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 47.91  E-value: 4.40e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15832830   38 QQCIGCAACVNACPSNALTVETDLATGelawefnlGRCIFCGRCEEVCPTAAIKL 92
Cdd:PRK09898 154 KRCIGCSACTTACPWMMATVNTESKKS--------SKCVLCGECANACPTGALKI 200
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 40-91 6.48e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 46.86  E-value: 6.48e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15832830  40 CIGCAACVNACPSNALTVeTDLATGELAW-----EFNLGRCIFCG-RCEEVCPTAAIK 91
Cdd:cd16373  16 CIRCGLCVEACPTGVIQP-AGLEDGLEGGrtpylDPREGPCDLCCdACVEVCPTGALR 72
Fer4_9 pfam13187
4Fe-4S dicluster domain;
39-90 7.00e-07

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 44.47  E-value: 7.00e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15832830    39 QCIGCAACVNACPSNALTVETDLATGELAWEFNlgRCIFCGRCEEVCPTAAI 90
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVGQTIRGDIAGL--ACIGCGACVDACPRGAI 50
SdhB/FrdB COG0479
Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and ...
 39-90 8.67e-07

Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440247 [Multi-domain]  Cd Length: 230  Bit Score: 47.43  E-value: 8.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  39 QCIGCAACVNACPS-------------------NALtvETDLATGE----LAWEFNLGRCIFCGRCEEVCP-----TAAI 90
Cdd:COG0479 143 ECILCGACVAACPNvwanpdflgpaalaqayrfALD--PRDEETEErleaLEDEEGVWRCTTCGNCTEVCPkgippTKAI 220
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 40-90 9.78e-07

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 45.32  E-value: 9.78e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15832830    40 CIGCAACVNACPSNALTVEtdlATGELAWEFNLGRCIFCGRCEEVCPTAAI 90
Cdd:TIGR00402  36 CTRCGECASACENNILQLG---QQGQPTVEFDNAECDFCGKCAEACPTNAF 83
Rama_corrin_act TIGR04270
methylamine methyltransferase corrinoid protein reductive activase; Members of this family ...
 40-94 1.48e-06

methylamine methyltransferase corrinoid protein reductive activase; Members of this family occur as paralogs in species capable of generating methane from mono-, di-, and tri-methylamine. Members include RamA (Reductive Activation of Methyltransfer, Amines) from Methanosarcina barkeri MS (DSM 800). Member proteins have two C-terminal motifs with four Cys each, likely to bind one 4Fe-4S cluster per motif.


Pssm-ID: 211993 [Multi-domain]  Cd Length: 535  Bit Score: 47.06  E-value: 1.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15832830    40 CIGCAACVNACPSNALTV-ETDLATgelaweFNLGRCI--FCGRCEEVCPTAAIKLSQ 94
Cdd:TIGR04270 481 CIACQKCVKECPGKALSIlESEPPR------IDTDRCLgtACRRCERVCPEKVFDIRN 532
PRK06273 PRK06273
ferredoxin; Provisional
 40-86 5.38e-06

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 44.32  E-value: 5.38e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15832830   40 CIGCAACVNACPSNALTVE-------TDLATGELAWEFNLGRCIFCGRCEEVCP 86
Cdd:PRK06273  51 CIGCGGCANVCPTKAIEMIpvepvkiTEGYVKTKIPKIDYEKCVYCLYCHDFCP 104
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 39-86 5.65e-06

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 45.45  E-value: 5.65e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832830  39 QCIGCAACVNACPSNALT------------VETDLATGELAWEFN------LGRCIFCGRCEEVCP 86
Cdd:COG0247  79 ACVGCGFCRAMCPSYKATgdekdsprgrinLLREVLEGELPLDLSeevyevLDLCLTCKACETACP 144
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 31-135 5.81e-06

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 44.99  E-value: 5.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  31 GKPEQNPQQCIGCAACVNACPSNALTVETD-LATgelaweFNLGRCIFCGRCEEVCPTAAIKL---SQEYELAVWKKEDF 106
Cdd:COG2878 130 GGPKGCEYGCIGCGDCIKACPFDAIVGAAKgMHT------VDEDKCTGCGLCVEACPVDCIEMvpvSPTVVVSSWDKGKA 203

                        90       100
                ....*....|....*....|....*....
gi 15832830 107 LQQSRFALCNCRVCNRPFAVQKEIDYAIA 135
Cdd:COG2878 204 VRKVVGCIGLCCKKCCPAAAITVNNLAAI 232
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 37-100 6.37e-06

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 43.53  E-value: 6.37e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832830  37 PQQCIGC--AACVNACPSNALTVEtdlATGELawEFNLGRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:cd04410  47 PVSCMHCedPPCVKACPTGAIYKD---EDGIV--LIDEDKCIGCGSCVEACPYGAIVFDPEPGKAV 107
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 39-87 1.10e-05

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 44.71  E-value: 1.10e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15832830  39 QCIGCAACVNACPsNALTVETDL---ATGELAWEFNL-GRCIFCGRCEEVCPT 87
Cdd:cd01916 366 KCTDCGWCTRACP-NSLRIKEAMeaaKEGDFSGLADLfDQCVGCGRCEQECPK 417
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 32-95 1.19e-05

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 44.22  E-value: 1.19e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15832830   32 KPEQNPQQCIGCAACVNACPSNALT---VETDLATGEL----AWEFNLGRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:PRK14028 241 KPVIDHSKCIMCRKCWLYCPDDAIIeawREAEGPRGRKfrmkMIDFDYQYCKGCGVCAEVCPTGAIQMVRE 311
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 36-111 1.41e-05

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 44.35  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   36 NPQQCIGCAACVNACPSNALTVE-TDLATGELAWEFNlgRCIFC-GR-----CEEVCPTAAIKLSQEYELAVWKKEDFLQ 108
Cdd:PRK12769  83 NQQKCIGCKSCVVACPFGTMQIVlTPVAAGKVKATAH--KCDLCaGRengpaCVENCPADALQLVTEQALSGMAKSRRLR 160


                 ...
gi 15832830  109 QSR 111
Cdd:PRK12769 161 TAR 163
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 24-92 1.43e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 42.71  E-value: 1.43e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15832830  24 AVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATGElawefnlgRCIFCGRCEEVCPTAAIKL 92
Cdd:cd16372  63 AITRDANGVVMINKKLCVGCLMCVGFCPEGAMFKHEDYPEPF--------KCIACGICVKACPTGALEL 123
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 36-95 1.71e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 42.56  E-value: 1.71e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15832830  36 NPQQCIGC--AACVNACPSNALTVetDLATGelAWEFNLGRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:cd10550  45 VPVVCRQCedAPCVEACPVGAISR--DEETG--AVVVDEDKCIGCGMCVEACPFGAIRVDPE 102
QueG COG1600
Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and ...
 34-86 4.53e-05

Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and biogenesis]; Epoxyqueuosine reductase QueG (queuosine biosynthesis) is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441208 [Multi-domain]  Cd Length: 345  Bit Score: 42.50  E-value: 4.53e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15832830  34 EQNPQQCIGCAACVNACPSNA---------------LTVETDlatGELAWEF--NLGRCIF-CGRCEEVCP 86
Cdd:COG1600 180 EPVEDHCGSCTRCLDACPTGAivapyvldarrcisyLTIELK---GPIPEELrpKMGNRIYgCDDCQDVCP 247
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
31-92 5.08e-05

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 41.18  E-value: 5.08e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15832830  31 GKPEQNPQQCIGCAACVNACPSNALTVETDLATGElawefnLGRCIFCG------RCEEVCPTAAIKL 92
Cdd:COG1142  74 GAVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAV------AVKCDLCGgreggpACVEACPTGALRL 135
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
13-95 5.08e-05

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 40.70  E-value: 5.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   13 TATSSYPLEPIAVDK---NFRG-----KPEQNPQQCIGCAACVNACPSNALTVETDlatGELAWEFNLgrCIFCGRCEEV 84
Cdd:PRK09623  18 KSVDEYPEAPISLGTtlsNFTGdwrtfMPVVDESKCVKCYICWKFCPEPAIYIKED---GYVAIDYDY--CKGCGICANE 92

                         90
                 ....*....|.
gi 15832830   85 CPTAAIKLSQE 95
Cdd:PRK09623  93 CPTKAITMVKE 103
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 36-92 5.86e-05

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 42.71  E-value: 5.86e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 15832830   36 NPQQCIGC--AACVNACPSNALTVETDlatgelAWEFNLGRCIFCGRCEEVCPTAAIKL 92
Cdd:PRK12809  52 NPVACHHCnnAPCVTACPVNALTFQSD------SVQLDEQKCIGCKRCAIACPFGVVEM 104
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 37-100 7.83e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 40.72  E-value: 7.83e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832830  37 PQQCIGC--AACVNACPSNALTVETDLATgelawEFNLGRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:cd16374  40 PVRCRHCedAPCMEVCPTGAIYRDEDGAV-----LVDPDKCIGCGMCAMACPFGVPRFDPSLKVAV 100
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 40-90 7.86e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 41.77  E-value: 7.86e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15832830   40 CIGCAACVNACPSNALTVEtdlaTGELAWEfnlGRCIFCGRCEEVCPTAAI 90
Cdd:NF038196 187 CIGCGICAKVCPVNNIEME----DGKPVWG---HNCTHCLACIHRCPKEAI 230
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 40-92 8.31e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 40.64  E-value: 8.31e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15832830  40 CIGCAACVNACPSNALTV--ETDLATgelawefnlgRCIFCG---RCEEVCPTAAIKL 92
Cdd:cd10550  82 CIGCGMCVEACPFGAIRVdpETGKAI----------KCDLCGgdpACVKVCPTGALEF 129
psaC CHL00065
photosystem I subunit VII
 40-87 1.03e-04

photosystem I subunit VII


Pssm-ID: 177005 [Multi-domain]  Cd Length: 81  Bit Score: 39.36  E-value: 1.03e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 15832830   40 CIGCAACVNACPSNAL-TVETD-LATGELAWEFNLGRCIFCGRCEEVCPT 87
Cdd:CHL00065  11 CIGCTQCVRACPTDVLeMIPWDgCKAKQIASAPRTEDCVGCKRCESACPT 60
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
40-92 1.05e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 41.46  E-value: 1.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 15832830   40 CIGCAACVNACPSNALTVETDLAtgelawEFNLGRCIFCGRCEEVCPTAAIKL 92
Cdd:PRK07118 141 CLGLGSCVAACPFDAIHIENGLP------VVDEDKCTGCGACVKACPRNVIEL 187
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
40-86 1.07e-04

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 38.63  E-value: 1.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15832830    40 CIGCAACVNACPSNAL----------------TVETDLATGELAWEFNLGRCIFCGRCEEVCP 86
Cdd:pfam13484   1 CGSCGKCIDACPTGAIvgpegvldarrcisylTIEKKGLIPDELRCLLGNRCYGCDICQDVCP 63
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
31-92 1.13e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 41.46  E-value: 1.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15832830   31 GKPEQNPQQCIGCAACVNACPSNALTVETDLA----------TGELAWEFNLGRCIFCGRCEEVCPTAAIKL 92
Cdd:PRK07118 161 GLPVVDEDKCTGCGACVKACPRNVIELIPKSArvfvacnskdKGKAVKKVCEVGCIGCGKCVKACPAGAITM 232
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 38-91 1.24e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 40.32  E-value: 1.24e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15832830  38 QQCIGCAACVNACPSNAltVETDLATGELAWEFNLGRCIFCGRCEEVCPT---AAIK 91
Cdd:cd16373  97 QGGTDCGVCVEACPTEA--IAIVLEDDVLRPVVDEDKCVGCGLCEYVCPVeppKAIV 151
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 40-93 1.30e-04

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 41.02  E-value: 1.30e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15832830   40 CIGCAACVNACPSNALTVETdlatGELAWEfNLGRCIFCGRCEEVCPTAAIKLS 93
Cdd:PRK00783 171 CDECEKCVEACPRGVLELKE----GKLVVT-DLLNCSLCKLCERACPGKAIRVS 219
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 32-105 1.54e-04

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 39.73  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   32 KPEQNPQQCIGCAACVNACPSNALTVETDLATGelaweFNLGRCIFCGRCEEVCPTAAIKL-------SQEYELAVW-KK 103
Cdd:PRK09625  53 KPVHNNEICINCFNCWVYCPDAAILSRDKKLKG-----VDYSHCKGCGVCVEVCPTNPKSLlmfeeqiENETALTQWpKK 127


                 ..
gi 15832830  104 ED 105
Cdd:PRK09625 128 EE 129
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 38-104 2.05e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 41.16  E-value: 2.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15832830   38 QQCIGCAACVNACPSNALTVETDLATgelawefnlgRCIFCGR-------CEEVCPTAAIKLSQEYELAVWKKE 104
Cdd:PRK12809  85 QKCIGCKRCAIACPFGVVEMVDTIAQ----------KCDLCNQrssgtqaCIEVCPTQALRLMDDKGLQQIKVA 148
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 37-92 2.50e-04

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 39.78  E-value: 2.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15832830    37 PQQCIGCAACVNACPSNAL--------TVETDLATGelawefnlgrcifCGRCEEVCPTAAIKL 92
Cdd:TIGR01944 112 EDNCIGCTKCIQACPVDAIvgaakamhTVIADECTG-------------CDLCVEPCPTDCIEM 162
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 31-90 2.87e-04

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 39.15  E-value: 2.87e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  31 GKPEQNPQQ--CIGCAACVNACPSNALTVETDLA--------TGELAWEFnlgrcIFCGRCEEVCPTAAI 90
Cdd:cd10564  36 GFPELDFSRgeCTFCGACAEACPEGALDPAREAPwplraeigDSCLALQG-----VECRSCQDACPTQAI 100
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 36-92 3.16e-04

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 38.91  E-value: 3.16e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832830  36 NPQQCIGCAACVNACPSNALTVETDLATGElawefnlgRCIFCG---------RCEEVCPTAAIKL 92
Cdd:cd04410  78 DEDKCIGCGSCVEACPYGAIVFDPEPGKAV--------KCDLCGdrldeglepACVKACPTGALTF 135
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 35-90 3.93e-04

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 39.44  E-value: 3.93e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15832830  35 QNPQQCIGCAACVNACPSNALTV-ETDLATGELAWEFNLGR---CIFC------GR---CEEVCPTAAI 90
Cdd:cd10551  80 VDYDKCIGCRYCMAACPYGARYFnPEEPHEFGEVPVRPKGVvekCTFCyhrldeGLlpaCVEACPTGAR 148
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 43-98 4.87e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 38.78  E-value: 4.87e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15832830  43 CAACVNACPSNALTVETDLATGE---LAWeFNLGRCI------FCGRCEEVCPTAAIKLSQEYEL 98
Cdd:cd16373  59 CDACVEVCPTGALRPLDLEEQKVkmgVAV-IDKDRCLawqggtDCGVCVEACPTEAIAIVLEDDV 122
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
36-90 5.88e-04

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 39.27  E-value: 5.88e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15832830   36 NPQQCIGCAACVNACPSNALTVETDLATGElawefnLGRCIFCGR-------------CEEVCPTAAI 90
Cdd:PRK10882 141 DKDVCTGCRYCMVACPFNVPKYDYNNPFGA------IHKCELCNQkgverldkgglpgCVEVCPTGAV 202
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 31-58 7.59e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 36.63  E-value: 7.59e-04
                        10        20
                ....*....|....*....|....*...
gi 15832830  31 GKPEQNPQQCIGCAACVNACPSNALTVE 58
Cdd:COG1149  34 GAPVVDPDLCTGCGACVGVCPTGAITLE 61
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 32-95 7.73e-04

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 37.32  E-value: 7.73e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15832830   32 KPEQNPQQCIGCAACVNACPSNALTVETdlatgELAWEFNLGRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:PRK09624  45 MPEFNRDKCVRCYLCYIYCPEPAIYLDE-----EGYPVFDYDYCKGCGICANECPTKAIEMVRE 103
PLN00071 PLN00071
photosystem I subunit VII; Provisional
 40-87 1.00e-03

photosystem I subunit VII; Provisional


Pssm-ID: 177700 [Multi-domain]  Cd Length: 81  Bit Score: 36.46  E-value: 1.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 15832830   40 CIGCAACVNACPSNAL-TVETD-LATGELAWEFNLGRCIFCGRCEEVCPT 87
Cdd:PLN00071  11 CIGCTQCVRACPTDVLeMIPWDgCKAKQIASAPRTEDCVGCKRCESACPT 60
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 64-93 1.04e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 36.18  E-value: 1.04e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 15832830  64 GELAWEFNLGRCIFCGRCEEVCPTAAIKLS 93
Cdd:COG2221   6 GTWPPKIDEEKCIGCGLCVAVCPTGAISLD 35
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 37-100 1.25e-03

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 37.62  E-value: 1.25e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832830  37 PQQCIGC--AACVNACPSNALTVETDlatgelAWEFNLGRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:cd10554  53 PVQCRQCedAPCANVCPVGAISQEDG------VVQVDEERCIGCKLCVLACPFGAIEMAPTTVPGV 112
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 38-86 1.25e-03

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 37.67  E-value: 1.25e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15832830  38 QQCIGC--AACVNACPSNALTVETDLATgelawEFNLGRCIFCGRCEEVCP 86
Cdd:cd10562  68 RQCMHCtdAACVKVCPTGALYKTENGAV-----VVDEDKCIGCGYCVAACP 113
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 37-95 1.43e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 37.62  E-value: 1.43e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15832830  37 PQQCIGC--AACVNACPSNALTVEtdlATGELAWEFNlgRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:COG0437  57 PVLCNHCddPPCVKVCPTGATYKR---EDGIVLVDYD--KCIGCRYCVAACPYGAPRFNPE 112
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 36-92 1.47e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 36.87  E-value: 1.47e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830  36 NPQQCIGCAACVNACPSNAltvetdlatgeLAWEFNLGR---CIFCGRCEEVCPTAAIKL 92
Cdd:cd16370  81 DKEKCIGCGNCVKACIVGA-----------IFWDEETNKpiiCIHCGYCARYCPHDVLAM 129
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 69-91 1.49e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 34.53  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|...
gi 15832830    69 EFNLGRCIFCGRCEEVCPTAAIK 91
Cdd:pfam00037   2 VIDEEKCIGCGACVEVCPVGAIT 24
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 35-91 1.60e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 37.62  E-value: 1.60e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15832830  35 QNPQQCIGCAACVNACPSNALTV--ETDLATgelawefnlgRCIFCG---------RCEEVCPTAAIK 91
Cdd:COG0437  87 VDYDKCIGCRYCVAACPYGAPRFnpETGVVE----------KCTFCAdrldegllpACVEACPTGALV 144
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 36-98 1.68e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 36.87  E-value: 1.68e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15832830  36 NPQQCIGCAACVNACPSNALTVETDLatgelaweFNLGRCIFCGR---------CEEVCPTAAIKLSQEYEL 98
Cdd:cd16374  71 DPDKCIGCGMCAMACPFGVPRFDPSL--------KVAVKCDLCIDrrregklpaCVEACPTGALKFGDIEEL 134
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
24-58 1.72e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 38.30  E-value: 1.72e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15832830  24 AVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVE 58
Cdd:COG1148 512 AISIDEKGVAEVNPALCKGCGTCAAACPSGAISLK 546
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 31-62 1.76e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 35.79  E-value: 1.76e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 15832830  31 GKPEQNPQQCIGCAACVNACPSNALTVETDLA 62
Cdd:COG4231  44 GKAVIDPDLCIGCGSCVQVCPVDAIKLEKRVP 75
PRK05113 PRK05113
electron transport complex protein RnfB; Provisional
 38-92 1.82e-03

electron transport complex protein RnfB; Provisional


Pssm-ID: 235347 [Multi-domain]  Cd Length: 191  Bit Score: 37.23  E-value: 1.82e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15832830   38 QQCIGCAACVNACPSNAL--------TVETDLATGelawefnlgrcifCGRCEEVCPTAAIKL 92
Cdd:PRK05113 114 DNCIGCTKCIQACPVDAIvgatkamhTVISDLCTG-------------CDLCVAPCPTDCIEM 163
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 31-58 2.38e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 35.03  E-value: 2.38e-03
                        10        20
                ....*....|....*....|....*...
gi 15832830  31 GKPEQNPQQCIGCAACVNACPSNALTVE 58
Cdd:COG2221  37 GKLVIDEEKCIGCGACIRVCPTGAIKGE 64
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
19-61 2.38e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 37.70  E-value: 2.38e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15832830  19 PLEPIAVDKnfrGKPEQNPQQCIGCAACVNACPSNALTVETDL 61
Cdd:COG4624 104 PVKAIKVDD---GKAEIDEEKCISCGQCVAVCPFGAITEKSDI 143
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 36-91 2.39e-03

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 37.37  E-value: 2.39e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15832830  36 NPQQCIGCAACVNACPSNalTVETDLATGeLAWefnlgRCIFC---------GRCEEVCPTAAIK 91
Cdd:cd10560 106 QPDICNGCGYCVAACPFG--VIDRNEETG-RAH-----KCTLCydrlkdglePACAKACPTGSIQ 162
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 33-58 2.51e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 36.45  E-value: 2.51e-03
                        10        20
                ....*....|....*....|....*.
gi 15832830  33 PEQNPQQCIGCAACVNACPSNALTVE 58
Cdd:cd10564 112 PELDADACTGCGACVSVCPVGAITLT 137
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
38-86 2.59e-03

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 37.34  E-value: 2.59e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15832830   38 QQCIGCA--ACVNACPSNALTveTDLATGELAWefNLGRCIFCGRCEEVCP 86
Cdd:PRK10882 110 KQCMHCVdpNCVSVCPVSALT--KDPKTGIVHY--DKDVCTGCRYCMVACP 156
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 40-95 2.69e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 36.10  E-value: 2.69e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15832830  40 CIGC--AACVNACPSNALTVETDLATgelawEFNLGRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:cd16370  53 CRACedPPCAEACPTGALEPRKGGGV-----VLDKEKCIGCGNCVKACIVGAIFWDEE 105
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 40-91 2.75e-03

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 36.21  E-value: 2.75e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15832830  40 CIGCAACVNACP-SNALTVETD------LATGELAWEFNLGRCIFCG--RCEEVCPTAAIK 91
Cdd:cd04410   8 CIGCGTCEVACKqEHGLRPGPDwsrikvIEGGGLERAFLPVSCMHCEdpPCVKACPTGAIY 68
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 25-65 3.19e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 34.72  E-value: 3.19e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15832830  25 VDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATGE 65
Cdd:COG1143  22 EDGEPGKVYVIDPDKCIGCGLCVEVCPTGAISMTPFELAVE 62
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 39-86 3.43e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 34.59  E-value: 3.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15832830    39 QCIGCAACVNACPSNALTVETDLATGELAWEFNLGR-------------CIFCGRCEEVCP 86
Cdd:pfam13183   1 RCIRCGACLAACPVYLVTGGRFPGDPRGGAAALLGRlealeglaeglwlCTLCGACTEVCP 61
NapF COG1145
Ferredoxin [Energy production and conversion];
43-92 3.43e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 37.01  E-value: 3.43e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 15832830  43 CAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGRCEEVCPTAAIKL 92
Cdd:COG1145 152 PVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRL 201
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 36-91 3.54e-03

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 36.42  E-value: 3.54e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15832830  36 NPQQCIGCAACVNACPSNALTVETDLATGELAwefnlgRCIFC------GR---CEEVCPTAAIK 91
Cdd:cd10561  97 DEDKCIGCRYCMVACPFNIPKYEWDSANPKIR------KCTMCydrlkeGKqpaCVEACPTGALL 155
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 40-86 3.56e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 34.36  E-value: 3.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15832830    40 CIGCAACVNACPSNALTvETDLATGELAWEFNLG----------RCIFCGRCEEVCP 86
Cdd:pfam13534   2 CIQCGCCVDECPRYLLN-GDEPKKLMRAAYLGDLeelqankvanLCSECGLCEYACP 57
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 19-52 4.01e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 36.08  E-value: 4.01e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15832830  19 PLEPIAVDKNFR-GKPEQNPQQCIGCAACVNACPS 52
Cdd:cd16373 110 PTEAIAIVLEDDvLRPVVDEDKCVGCGLCEYVCPV 144
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 44-95 4.25e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 36.00  E-value: 4.25e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 15832830  44 AACVNACPSNALTVETDLATgelawEFNLGRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:cd16371  60 PACVKVCPTGAITKREDGIV-----VVDQDKCIGCGYCVWACPYGAPQYNPE 106
PRK10194 PRK10194
ferredoxin-type protein NapF;
39-86 4.77e-03

ferredoxin-type protein NapF;


Pssm-ID: 182296 [Multi-domain]  Cd Length: 163  Bit Score: 36.15  E-value: 4.77e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 15832830   39 QCIGCAACVNACPSNALTVETDlatGELAWEFNLGRCIFCGRCEEVCP 86
Cdd:PRK10194  35 HCTRCDACINACENNILQRGAG---GYPSVNFKNNECSFCYACAQACP 79
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
32-59 5.49e-03

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 36.19  E-value: 5.49e-03
                        10        20
                ....*....|....*....|....*...
gi 15832830  32 KPEQNPQQCIGCAACVNACPSNALTVET 59
Cdd:COG0348 230 KGEINQSECINCGRCIDACPKDAIRFSS 257
napH_ TIGR02163
ferredoxin-type protein, NapH/MauN family; Most members of this family are the NapH protein, ...
 35-93 6.18e-03

ferredoxin-type protein, NapH/MauN family; Most members of this family are the NapH protein, found next to NapG,in operons that encode the periplasmic nitrate reductase. Some species with this reductase lack NapC but accomplish electron transfer to NapAB in some other manner, likely to involve NapH, NapG, and/or some other protein. A few members of this protein are designated MauN and are found in methylamine utilization operons in species that appear to lack a periplasmic nitrate reductase.


Pssm-ID: 274004 [Multi-domain]  Cd Length: 255  Bit Score: 36.17  E-value: 6.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15832830    35 QNPQQCIGCAACVNACPSNALTVETDLATGELAweFNLGRCIFCGRCEEVCPTAAIKLS 93
Cdd:TIGR02163 198 SDREKCTNCMDCFNVCPEPQVLRMPLKKGGSTL--VLSGDCTLCGRCIDVCHEDVLGFT 254
PRK10194 PRK10194
ferredoxin-type protein NapF;
32-62 6.18e-03

ferredoxin-type protein NapF;


Pssm-ID: 182296 [Multi-domain]  Cd Length: 163  Bit Score: 35.77  E-value: 6.18e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 15832830   32 KPEQNPQQCIGCAACVNACPSNALTVETDLA 62
Cdd:PRK10194 132 QPQLNSQLCNGCGACAASCPVSAITAEYLHA 162
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 36-91 6.66e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 35.45  E-value: 6.66e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15832830  36 NPQQCIGCAACVNACPSNALTVEtdlatgelaWEFNL-GRCIFC------GR---CEEVCPTAAIK 91
Cdd:cd16366  98 DPETCIGCGYCVNACPFDIPRFD---------EETGRvAKCTLCydrisnGLqpaCVKTCPTGALT 154
PRK12385 PRK12385
succinate dehydrogenase/fumarate reductase iron-sulfur subunit;
31-102 6.79e-03

succinate dehydrogenase/fumarate reductase iron-sulfur subunit;


Pssm-ID: 183490 [Multi-domain]  Cd Length: 244  Bit Score: 35.83  E-value: 6.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832830   31 GKPEQNPQQ---------CIGCAACVNACPSNALTVE-TDLATGELAWEFNLGR--------------------CIFCGR 80
Cdd:PRK12385 131 GPNKQTPAQmakyhqfsgCINCGLCYAACPQFGLNPEfIGPAAITLAHRYNLDSrdhgkkermkqlngqngvwsCTFVGY 210

                         90       100       110
                 ....*....|....*....|....*....|..
gi 15832830   81 CEEVC-----PTAAIKL-----SQEYELAVWK 102
Cdd:PRK12385 211 CSEVCpkhvdPAAAIQQgkvesAKDFLIAMLK 242
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 36-91 7.02e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 35.00  E-value: 7.02e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15832830  36 NPQQCIGCAACVNACpSNALTVETD-----LATGELAWEFNLGRCIFCGRCEEVCPTAAIK 91
Cdd:cd16372   6 DPEKCIGCLQCEEAC-SKTFFKEEDrekscIRITETEGGYAINVCNQCGECIDVCPTGAIT 65
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 74-104 7.35e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 35.99  E-value: 7.35e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 15832830   74 RCIFCGRCEEVCPTAAIKLSQEYelAVWKKE 104
Cdd:NF038196 186 KCIGCGICAKVCPVNNIEMEDGK--PVWGHN 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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