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Conserved domains on  [gi|15832846|ref|NP_311619|]
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4-hydroxybenzoate decarboxylase [Escherichia coli O157:H7 str. Sakai]

Protein Classification

UbiD family decarboxylase( domain architecture ID 10000493)

UbiD family decarboxylase may catalyze the reversible decarboxylation of aromatic carboxylic acids

EC:  4.1.1.-
Gene Ontology:  GO:0016831|GO:0046872
SCOP:  4000458|4001862

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
VdcC NF041204
non-oxidative hydroxyarylic acid decarboxylases subunit C;
3-470 0e+00

non-oxidative hydroxyarylic acid decarboxylases subunit C;


:

Pssm-ID: 469108  Cd Length: 467  Bit Score: 922.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    3 FDDLRSFLQALDDHGQLLKISEEVNAEPDLAAAANATGRIGDGAPALWFDNIRGFTDARVAMNTIGSWQNHAISLGLPPN 82
Cdd:NF041204   1 YNDLRSFLDLLEEEGQLLRITDEVDPEPDISAAARAAGNLGDGGPALLFDNIKGYPGARVALNVHGSWANHALMLGLPKN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   83 TPVKKQIDEFIRRWDNFPIAPERRANPAWAQNTVdGDEINLFDILPLFRLNDGDGGFYLDKACVVSRDPLDPDNFGKQNV 162
Cdd:NF041204  81 TPVKEQFFEFARRWDKFPVPPERVDQAPCQENTI-TEDINLFDLLPLFRLNEGDGGFYIDKACVVSRDPEDPDNFGKQNV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  163 GIYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRESPYPIATA 242
Cdd:NF041204 160 GIYRLQVKGKDRLGIQPVPFHDIAVHLRKAEERGEPLPIAIAIGNDPVITIMASTPLGYDQSEYEMAGALRGAPYPITKA 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  243 PLTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRPIFESLYLGMPWTEIDYLMGPATC 322
Cdd:NF041204 240 PTTGLDVPAGSEVVIEGEILPRVREIEGPFGEFPGSYSGGRKMPVIKITRVTHRTNPIFESLYLGMPWTEIDYLIGLNTS 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  323 VPLYQQLKAEFPEVQAVNAMYTHGLLAIISTKKRYGGFARAVGLRAMTTPHGLGYVKMVIMVDEDVDPFNLPQVMWALSS 402
Cdd:NF041204 320 VPLYQQLKAAFPEVQAVNAMYTHGLVAIISTKKRYGGFAKAVAMRALSTPHGLGYLKIVIVVDEDVDPFNLPQVMWALST 399
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15832846  403 KVNPAGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTPVAPDNRGHYSQPVVDLPETKAWAEKLTAM 470
Cdd:NF041204 400 RVRPAKDVIVIPNMSVLPLDPSSEPPGITHKLIIDATTPVAPDPRGHYTQLVDDPPETDKWEKKLRKL 467
 
Name Accession Description Interval E-value
VdcC NF041204
non-oxidative hydroxyarylic acid decarboxylases subunit C;
3-470 0e+00

non-oxidative hydroxyarylic acid decarboxylases subunit C;


Pssm-ID: 469108  Cd Length: 467  Bit Score: 922.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    3 FDDLRSFLQALDDHGQLLKISEEVNAEPDLAAAANATGRIGDGAPALWFDNIRGFTDARVAMNTIGSWQNHAISLGLPPN 82
Cdd:NF041204   1 YNDLRSFLDLLEEEGQLLRITDEVDPEPDISAAARAAGNLGDGGPALLFDNIKGYPGARVALNVHGSWANHALMLGLPKN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   83 TPVKKQIDEFIRRWDNFPIAPERRANPAWAQNTVdGDEINLFDILPLFRLNDGDGGFYLDKACVVSRDPLDPDNFGKQNV 162
Cdd:NF041204  81 TPVKEQFFEFARRWDKFPVPPERVDQAPCQENTI-TEDINLFDLLPLFRLNEGDGGFYIDKACVVSRDPEDPDNFGKQNV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  163 GIYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRESPYPIATA 242
Cdd:NF041204 160 GIYRLQVKGKDRLGIQPVPFHDIAVHLRKAEERGEPLPIAIAIGNDPVITIMASTPLGYDQSEYEMAGALRGAPYPITKA 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  243 PLTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRPIFESLYLGMPWTEIDYLMGPATC 322
Cdd:NF041204 240 PTTGLDVPAGSEVVIEGEILPRVREIEGPFGEFPGSYSGGRKMPVIKITRVTHRTNPIFESLYLGMPWTEIDYLIGLNTS 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  323 VPLYQQLKAEFPEVQAVNAMYTHGLLAIISTKKRYGGFARAVGLRAMTTPHGLGYVKMVIMVDEDVDPFNLPQVMWALSS 402
Cdd:NF041204 320 VPLYQQLKAAFPEVQAVNAMYTHGLVAIISTKKRYGGFAKAVAMRALSTPHGLGYLKIVIVVDEDVDPFNLPQVMWALST 399
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15832846  403 KVNPAGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTPVAPDNRGHYSQPVVDLPETKAWAEKLTAM 470
Cdd:NF041204 400 RVRPAKDVIVIPNMSVLPLDPSSEPPGITHKLIIDATTPVAPDPRGHYTQLVDDPPETDKWEKKLRKL 467
UbiD COG0043
3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme transport and metabolism]; ...
1-467 5.57e-173

3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme transport and metabolism]; 3-polyprenyl-4-hydroxybenzoate decarboxylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 439813  Cd Length: 459  Bit Score: 493.88  E-value: 5.57e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   1 MAFDDLRSFLQALDDHGQLLKISEEVNAEPDLAAAANATGRIGdgAPALWFDNIRGFtDARVAMNTIGSWQNHAISLGLP 80
Cdd:COG0043   1 MAYRDLREFLAALEKRGELKRIKEPVDPDLEITAITRRVLRAG--GPALLFENVKGY-GFPVLGNLFGSRERVALALGVP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  81 PNTPVKKqideFIRRWDNFPIAPERRANPAWAQNTVDGDEINLfDILPLFRLNDGDGGFYLDKACVVSRDPLDpdnfGKQ 160
Cdd:COG0043  78 PDELGER----LAEALKKEPIPPKVVSSAPCQEVVLTGDDVDL-TKLPIPTCWPGDGGPYITLGLVITKDPET----GWQ 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846 161 NVGIYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRESPYPIA 240
Cdd:COG0043 149 NVGIYRMQVLDKNTLGMHWLPHRHGALHYRKAEERGKPLPVAVAIGADPATILAAVAPLPYGVDEYEFAGALRGEPVELV 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846 241 TAPLTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRPIFESLYLGMPWtEIDYLMGPA 320
Cdd:COG0043 229 KCETVDLEVPANAEIVLEGYIDPGERAPEGPFGEHTGYYSPVDPFPVFRVTAITHRKDPIYPSTVVGRPP-EEDALLGIA 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846 321 TCVPLYQQLKAEFPEVQAVNAMYTHG--LLAIISTKKRYGGFARAVGLRAMTTPHGLgYVKMVIMVDEDVDPFNLPQVMW 398
Cdd:COG0043 308 TEAIFLPLLRKAFPEVVDVYLPPEGCsrRLAVVSIKKRYPGHAKRVMMAAWGLGQMM-YTKFVIVVDDDVDPRDLNEVLW 386
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15832846 399 ALSSKVNPAGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTPVAPDNRGHYSQPVVDLPETKAWAEKL 467
Cdd:COG0043 387 ALATRVDPDRDVVIIPNTPGDPLDPSSPPPGLGSKMGIDATRKWPEEGGREFPEPIEMPPEVKARVDEL 455
TIGR00148 TIGR00148
UbiD family decarboxylase; The member of this family in E. coli is UbiD, ...
6-441 5.35e-155

UbiD family decarboxylase; The member of this family in E. coli is UbiD, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. The family described by this model, however, is broad enough that it is likely to contain several different decarboxylases. Found in bacteria, archaea, and yeast, with two members in A. fulgidus. No homologs were detected besides those classified as orthologs. The member from H. pylori has a C-terminal extension of just over 100 residues that is shared in part by the Aquifex aeolicus homolog. [Unknown function, General]


Pssm-ID: 129252  Cd Length: 438  Bit Score: 447.21  E-value: 5.35e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846     6 LRSFLQALDDHGQLLKISEEVNAEPDLAAAANATGRigDGAPALWFDNIRGFtDARVAMNTIGSWQNHAISLGLP----- 80
Cdd:TIGR00148   1 MRDFIQLLEKEGELLRITEEVDPDLEVAEIARRALR--AGGPALLFKNPKGY-GFPVLMNLFGSRERLALALGVDgkrla 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    81 ----PNTP-VKKQIDEFIRRWDNFPIAPERRANPAWAQNTVDGDEINLfDILPLFRLNDGDGGFYLDKACVVSRDPldpd 155
Cdd:TIGR00148  78 hllePDPPkFKEAFDFLARLKDKMEMPPKRTSVAPCKEKIISEDDVNL-QELPILKCWPKDGGYYITAGVVITQDP---- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   156 NFGKQNVGIYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRES 235
Cdd:TIGR00148 153 DTGKQNLGIYRMQVIDKDRLGIRWVPPRHGALHLRKAAERGEKLPVAIAIGVDPATLLAASTPIPYGLSEYEFAGAIRGE 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   236 PYPIATAPLTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRPIFESLYLGMPWTEiDY 315
Cdd:TIGR00148 233 KLRVVKCETNDLEVPADAEIVLEGTITAGETELEGPFGDHTGYYDIVRPEPVITVKRMYHREDPIYHATYPGGPPHE-DA 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   316 LMGPATCVPLYQQLKAEFPEVQAVN--AMYTHGLLAIISTKKRYGGFARAVGLRAMTTpHGLGYVKMVIMVDEDVDPFNL 393
Cdd:TIGR00148 312 LMGVPTEPVFYPILRNQVPEIIDAVlpEGGCHWLLAVVSIKKRYPGDAKNVIMAAWAA-LQFPYTKHVIVVDDDINIFDP 390
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 15832846   394 PQVMWALSSKVNPAGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTP 441
Cdd:TIGR00148 391 NDVIWAIATRFDPDRDIVIVPGAPGDSLDPASPPSGLTGKMGIDATTK 438
UbiD pfam01977
3-octaprenyl-4-hydroxybenzoate carboxy-lyase; This family has been characterized as ...
10-416 7.04e-134

3-octaprenyl-4-hydroxybenzoate carboxy-lyase; This family has been characterized as 3-octaprenyl-4- hydroxybenzoate carboxy-lyase enzymes. This enzyme catalyzes the third reaction in ubiquinone biosynthesis. For optimal activity the carboxy-lase was shown to require Mn2+.


Pssm-ID: 426542 [Multi-domain]  Cd Length: 401  Bit Score: 392.24  E-value: 7.04e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    10 LQALDDHGQLLKISEEVNAEPDLAAAANATgrIGDGAPALWFDNIRGFtDARVAMNTIGSWQNHAISLGLPPntpvkkqI 89
Cdd:pfam01977   1 LEALEKEGELVRIDEEVDPDLEIAAIARRV--LEAGGPALLFENVKGF-GFPVLGNLFGTRERVALALGLTS-------L 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    90 DEFIRRW----DNFPIAPER--RANPAWAQNTVDGDEINLFDiLPLFRLNDGDGGFYLDKACVVSRDPLDpdnfGKQNVG 163
Cdd:pfam01977  71 EEIGERLaellEPPPIPPKKvdSSSAPCQEEVLEGDDVDLSK-LPVPTHWPGDGGPYITLGLVITKDPDT----GWTNLG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   164 IYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRESPYPIATAP 243
Cdd:pfam01977 146 IYRMQVLGKNTLGLHWQIHKGGAIHLRKYLERGEPLPVAIAIGGDPALTLAAVAPLPEGVDELEFAGALRGEPVELVKCE 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   244 LTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGR-NMTVVRIDKVSYRTRPIFESLYLGMPWTEiDYLMGPATC 322
Cdd:pfam01977 226 TVDLPVPADAEIVLEGYIDPGETAPEGPFGDHTGYYSGVRdPFPVFKVTAITHRKDPIYPTTVVGRPPEE-DTLLGLATE 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   323 VPLYQQLKAEFPEVQAVNAMY--THGLLAIISTKKRYGGFARAVGLRAMTTPHGLGYVKMVIMVDEDVDPFNLPQVMWAL 400
Cdd:pfam01977 305 ALILPLLRRGVPEVVDVHLPPegGFHLHAVVSIKKRYPGHAKQVMMALFGAGPQMSLTKHVIVVDEDVDIFDLEDVLWAI 384
                         410
                  ....*....|....*.
gi 15832846   401 SSKVNPAGDLVQLPNM 416
Cdd:pfam01977 385 ATRVDPDRDLVIIPGT 400
PRK10922 PRK10922
4-hydroxy-3-polyprenylbenzoate decarboxylase;
1-472 9.29e-55

4-hydroxy-3-polyprenylbenzoate decarboxylase;


Pssm-ID: 236796  Cd Length: 497  Bit Score: 190.51  E-value: 9.29e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    1 MAFDDLRSFLQALDDHGQLLKISEEVNAEPDLAAAANATGRIGdgAPALWFDNIRGFtDARVAMNTIGSWQNHAISLG-- 78
Cdd:PRK10922   4 MKYRDLRDFLTLLEQQGELKRITLPVDPHLEITEIADRTLRAG--GPALLFENPKGY-SMPVLCNLFGTPKRVAMGMGqe 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   79 --------------LPPNTPVKKQIDEF--IRRWDNFPIAPERRANPAWAQNTV-DGDEINLFDIlPLFRLNDGDGGFYL 141
Cdd:PRK10922  81 dvsalrevgkllafLKEPEPPKGFRDLFdkLPQFKQVLNMPTKRLRGAPCQQKIwSGDDVDLNRI-PIMTCWPEDAAPLI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  142 DKACVVSRDPldpdNFGKQNVGIYRMEVKGKRKLGLQPVPMHDIALHLHK--AEERGEDLPIAITLGNDPIITLMGATPL 219
Cdd:PRK10922 160 TWGLTVTRGP----HKERQNLGIYRQQLIGKNKLIMRWLSHRGGALDYQEwcAAHPGERFPVSVALGADPATILGAVTPV 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  220 KYDQSEYEMAGALRESPYPIATAPLTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRP 299
Cdd:PRK10922 236 PDTLSEYAFAGLLRGTKTEVVKCLSNDLEVPASAEIVLEGYIEPGEMAPEGPYGDHTGYYNEVDSFPVFTVTHITQREDA 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  300 IFESLYLGMPWTEiDYLMGPA---TCVPLYQQlkaEFPEV-----QAVNAMYThglLAIISTKKRYGGFARAVGLRAMTT 371
Cdd:PRK10922 316 IYHSTYTGRPPDE-PAVLGVAlneVFVPILQK---QFPEIvdfylPPEGCSYR---LAVVTIKKQYAGHAKRVMMGVWSF 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  372 PHGLGYVKMVIMVDEDVDPFNLPQVMWALSSKVNPAGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTPVAPDNRGHYS 451
Cdd:PRK10922 389 LRQFMYTKFVIVCDDDVNARDWNDVIWAITTRMDPARDTVLVENTPIDYLDFASPVSGLGSKMGLDATNKWPGETQREWG 468
                        490       500
                 ....*....|....*....|.
gi 15832846  452 QPVVDLPETKAWAEKLTAMLA 472
Cdd:PRK10922 469 RPIKKDPDVVARIDAIWDELA 489
 
Name Accession Description Interval E-value
VdcC NF041204
non-oxidative hydroxyarylic acid decarboxylases subunit C;
3-470 0e+00

non-oxidative hydroxyarylic acid decarboxylases subunit C;


Pssm-ID: 469108  Cd Length: 467  Bit Score: 922.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    3 FDDLRSFLQALDDHGQLLKISEEVNAEPDLAAAANATGRIGDGAPALWFDNIRGFTDARVAMNTIGSWQNHAISLGLPPN 82
Cdd:NF041204   1 YNDLRSFLDLLEEEGQLLRITDEVDPEPDISAAARAAGNLGDGGPALLFDNIKGYPGARVALNVHGSWANHALMLGLPKN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   83 TPVKKQIDEFIRRWDNFPIAPERRANPAWAQNTVdGDEINLFDILPLFRLNDGDGGFYLDKACVVSRDPLDPDNFGKQNV 162
Cdd:NF041204  81 TPVKEQFFEFARRWDKFPVPPERVDQAPCQENTI-TEDINLFDLLPLFRLNEGDGGFYIDKACVVSRDPEDPDNFGKQNV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  163 GIYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRESPYPIATA 242
Cdd:NF041204 160 GIYRLQVKGKDRLGIQPVPFHDIAVHLRKAEERGEPLPIAIAIGNDPVITIMASTPLGYDQSEYEMAGALRGAPYPITKA 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  243 PLTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRPIFESLYLGMPWTEIDYLMGPATC 322
Cdd:NF041204 240 PTTGLDVPAGSEVVIEGEILPRVREIEGPFGEFPGSYSGGRKMPVIKITRVTHRTNPIFESLYLGMPWTEIDYLIGLNTS 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  323 VPLYQQLKAEFPEVQAVNAMYTHGLLAIISTKKRYGGFARAVGLRAMTTPHGLGYVKMVIMVDEDVDPFNLPQVMWALSS 402
Cdd:NF041204 320 VPLYQQLKAAFPEVQAVNAMYTHGLVAIISTKKRYGGFAKAVAMRALSTPHGLGYLKIVIVVDEDVDPFNLPQVMWALST 399
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15832846  403 KVNPAGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTPVAPDNRGHYSQPVVDLPETKAWAEKLTAM 470
Cdd:NF041204 400 RVRPAKDVIVIPNMSVLPLDPSSEPPGITHKLIIDATTPVAPDPRGHYTQLVDDPPETDKWEKKLRKL 467
UbiD COG0043
3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme transport and metabolism]; ...
1-467 5.57e-173

3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme transport and metabolism]; 3-polyprenyl-4-hydroxybenzoate decarboxylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 439813  Cd Length: 459  Bit Score: 493.88  E-value: 5.57e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   1 MAFDDLRSFLQALDDHGQLLKISEEVNAEPDLAAAANATGRIGdgAPALWFDNIRGFtDARVAMNTIGSWQNHAISLGLP 80
Cdd:COG0043   1 MAYRDLREFLAALEKRGELKRIKEPVDPDLEITAITRRVLRAG--GPALLFENVKGY-GFPVLGNLFGSRERVALALGVP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  81 PNTPVKKqideFIRRWDNFPIAPERRANPAWAQNTVDGDEINLfDILPLFRLNDGDGGFYLDKACVVSRDPLDpdnfGKQ 160
Cdd:COG0043  78 PDELGER----LAEALKKEPIPPKVVSSAPCQEVVLTGDDVDL-TKLPIPTCWPGDGGPYITLGLVITKDPET----GWQ 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846 161 NVGIYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRESPYPIA 240
Cdd:COG0043 149 NVGIYRMQVLDKNTLGMHWLPHRHGALHYRKAEERGKPLPVAVAIGADPATILAAVAPLPYGVDEYEFAGALRGEPVELV 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846 241 TAPLTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRPIFESLYLGMPWtEIDYLMGPA 320
Cdd:COG0043 229 KCETVDLEVPANAEIVLEGYIDPGERAPEGPFGEHTGYYSPVDPFPVFRVTAITHRKDPIYPSTVVGRPP-EEDALLGIA 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846 321 TCVPLYQQLKAEFPEVQAVNAMYTHG--LLAIISTKKRYGGFARAVGLRAMTTPHGLgYVKMVIMVDEDVDPFNLPQVMW 398
Cdd:COG0043 308 TEAIFLPLLRKAFPEVVDVYLPPEGCsrRLAVVSIKKRYPGHAKRVMMAAWGLGQMM-YTKFVIVVDDDVDPRDLNEVLW 386
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15832846 399 ALSSKVNPAGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTPVAPDNRGHYSQPVVDLPETKAWAEKL 467
Cdd:COG0043 387 ALATRVDPDRDVVIIPNTPGDPLDPSSPPPGLGSKMGIDATRKWPEEGGREFPEPIEMPPEVKARVDEL 455
TIGR00148 TIGR00148
UbiD family decarboxylase; The member of this family in E. coli is UbiD, ...
6-441 5.35e-155

UbiD family decarboxylase; The member of this family in E. coli is UbiD, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. The family described by this model, however, is broad enough that it is likely to contain several different decarboxylases. Found in bacteria, archaea, and yeast, with two members in A. fulgidus. No homologs were detected besides those classified as orthologs. The member from H. pylori has a C-terminal extension of just over 100 residues that is shared in part by the Aquifex aeolicus homolog. [Unknown function, General]


Pssm-ID: 129252  Cd Length: 438  Bit Score: 447.21  E-value: 5.35e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846     6 LRSFLQALDDHGQLLKISEEVNAEPDLAAAANATGRigDGAPALWFDNIRGFtDARVAMNTIGSWQNHAISLGLP----- 80
Cdd:TIGR00148   1 MRDFIQLLEKEGELLRITEEVDPDLEVAEIARRALR--AGGPALLFKNPKGY-GFPVLMNLFGSRERLALALGVDgkrla 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    81 ----PNTP-VKKQIDEFIRRWDNFPIAPERRANPAWAQNTVDGDEINLfDILPLFRLNDGDGGFYLDKACVVSRDPldpd 155
Cdd:TIGR00148  78 hllePDPPkFKEAFDFLARLKDKMEMPPKRTSVAPCKEKIISEDDVNL-QELPILKCWPKDGGYYITAGVVITQDP---- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   156 NFGKQNVGIYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRES 235
Cdd:TIGR00148 153 DTGKQNLGIYRMQVIDKDRLGIRWVPPRHGALHLRKAAERGEKLPVAIAIGVDPATLLAASTPIPYGLSEYEFAGAIRGE 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   236 PYPIATAPLTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRPIFESLYLGMPWTEiDY 315
Cdd:TIGR00148 233 KLRVVKCETNDLEVPADAEIVLEGTITAGETELEGPFGDHTGYYDIVRPEPVITVKRMYHREDPIYHATYPGGPPHE-DA 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   316 LMGPATCVPLYQQLKAEFPEVQAVN--AMYTHGLLAIISTKKRYGGFARAVGLRAMTTpHGLGYVKMVIMVDEDVDPFNL 393
Cdd:TIGR00148 312 LMGVPTEPVFYPILRNQVPEIIDAVlpEGGCHWLLAVVSIKKRYPGDAKNVIMAAWAA-LQFPYTKHVIVVDDDINIFDP 390
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 15832846   394 PQVMWALSSKVNPAGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTP 441
Cdd:TIGR00148 391 NDVIWAIATRFDPDRDIVIVPGAPGDSLDPASPPSGLTGKMGIDATTK 438
UbiD pfam01977
3-octaprenyl-4-hydroxybenzoate carboxy-lyase; This family has been characterized as ...
10-416 7.04e-134

3-octaprenyl-4-hydroxybenzoate carboxy-lyase; This family has been characterized as 3-octaprenyl-4- hydroxybenzoate carboxy-lyase enzymes. This enzyme catalyzes the third reaction in ubiquinone biosynthesis. For optimal activity the carboxy-lase was shown to require Mn2+.


Pssm-ID: 426542 [Multi-domain]  Cd Length: 401  Bit Score: 392.24  E-value: 7.04e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    10 LQALDDHGQLLKISEEVNAEPDLAAAANATgrIGDGAPALWFDNIRGFtDARVAMNTIGSWQNHAISLGLPPntpvkkqI 89
Cdd:pfam01977   1 LEALEKEGELVRIDEEVDPDLEIAAIARRV--LEAGGPALLFENVKGF-GFPVLGNLFGTRERVALALGLTS-------L 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    90 DEFIRRW----DNFPIAPER--RANPAWAQNTVDGDEINLFDiLPLFRLNDGDGGFYLDKACVVSRDPLDpdnfGKQNVG 163
Cdd:pfam01977  71 EEIGERLaellEPPPIPPKKvdSSSAPCQEEVLEGDDVDLSK-LPVPTHWPGDGGPYITLGLVITKDPDT----GWTNLG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   164 IYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRESPYPIATAP 243
Cdd:pfam01977 146 IYRMQVLGKNTLGLHWQIHKGGAIHLRKYLERGEPLPVAIAIGGDPALTLAAVAPLPEGVDELEFAGALRGEPVELVKCE 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   244 LTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGR-NMTVVRIDKVSYRTRPIFESLYLGMPWTEiDYLMGPATC 322
Cdd:pfam01977 226 TVDLPVPADAEIVLEGYIDPGETAPEGPFGDHTGYYSGVRdPFPVFKVTAITHRKDPIYPTTVVGRPPEE-DTLLGLATE 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   323 VPLYQQLKAEFPEVQAVNAMY--THGLLAIISTKKRYGGFARAVGLRAMTTPHGLGYVKMVIMVDEDVDPFNLPQVMWAL 400
Cdd:pfam01977 305 ALILPLLRRGVPEVVDVHLPPegGFHLHAVVSIKKRYPGHAKQVMMALFGAGPQMSLTKHVIVVDEDVDIFDLEDVLWAI 384
                         410
                  ....*....|....*.
gi 15832846   401 SSKVNPAGDLVQLPNM 416
Cdd:pfam01977 385 ATRVDPDRDLVIIPGT 400
PRK10922 PRK10922
4-hydroxy-3-polyprenylbenzoate decarboxylase;
1-472 9.29e-55

4-hydroxy-3-polyprenylbenzoate decarboxylase;


Pssm-ID: 236796  Cd Length: 497  Bit Score: 190.51  E-value: 9.29e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846    1 MAFDDLRSFLQALDDHGQLLKISEEVNAEPDLAAAANATGRIGdgAPALWFDNIRGFtDARVAMNTIGSWQNHAISLG-- 78
Cdd:PRK10922   4 MKYRDLRDFLTLLEQQGELKRITLPVDPHLEITEIADRTLRAG--GPALLFENPKGY-SMPVLCNLFGTPKRVAMGMGqe 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846   79 --------------LPPNTPVKKQIDEF--IRRWDNFPIAPERRANPAWAQNTV-DGDEINLFDIlPLFRLNDGDGGFYL 141
Cdd:PRK10922  81 dvsalrevgkllafLKEPEPPKGFRDLFdkLPQFKQVLNMPTKRLRGAPCQQKIwSGDDVDLNRI-PIMTCWPEDAAPLI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  142 DKACVVSRDPldpdNFGKQNVGIYRMEVKGKRKLGLQPVPMHDIALHLHK--AEERGEDLPIAITLGNDPIITLMGATPL 219
Cdd:PRK10922 160 TWGLTVTRGP----HKERQNLGIYRQQLIGKNKLIMRWLSHRGGALDYQEwcAAHPGERFPVSVALGADPATILGAVTPV 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  220 KYDQSEYEMAGALRESPYPIATAPLTGFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRP 299
Cdd:PRK10922 236 PDTLSEYAFAGLLRGTKTEVVKCLSNDLEVPASAEIVLEGYIEPGEMAPEGPYGDHTGYYNEVDSFPVFTVTHITQREDA 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  300 IFESLYLGMPWTEiDYLMGPA---TCVPLYQQlkaEFPEV-----QAVNAMYThglLAIISTKKRYGGFARAVGLRAMTT 371
Cdd:PRK10922 316 IYHSTYTGRPPDE-PAVLGVAlneVFVPILQK---QFPEIvdfylPPEGCSYR---LAVVTIKKQYAGHAKRVMMGVWSF 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832846  372 PHGLGYVKMVIMVDEDVDPFNLPQVMWALSSKVNPAGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTPVAPDNRGHYS 451
Cdd:PRK10922 389 LRQFMYTKFVIVCDDDVNARDWNDVIWAITTRMDPARDTVLVENTPIDYLDFASPVSGLGSKMGLDATNKWPGETQREWG 468
                        490       500
                 ....*....|....*....|.
gi 15832846  452 QPVVDLPETKAWAEKLTAMLA 472
Cdd:PRK10922 469 RPIKKDPDVVARIDAIWDELA 489
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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