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Conserved domains on  [gi|15832848|ref|NP_311621|]
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transcriptional regulator [Escherichia coli O157:H7 str. Sakai]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-133 4.65e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.73  E-value: 4.65e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832848   2 TLRNKAFHQLRQLFQQHTARWQHEL--PDLTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREH 79
Cdd:COG1846   7 PAEERLGLLLRRLARALRRALDRALaeLGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15832848  80 DAADKRRRFVWLTAEGEKILAAAIPIGDSVDEEFLGRLSAEEQELFVQLVRKMM 133
Cdd:COG1846  87 DPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-133 4.65e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.73  E-value: 4.65e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832848   2 TLRNKAFHQLRQLFQQHTARWQHEL--PDLTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREH 79
Cdd:COG1846   7 PAEERLGLLLRRLARALRRALDRALaeLGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15832848  80 DAADKRRRFVWLTAEGEKILAAAIPIGDSVDEEFLGRLSAEEQELFVQLVRKMM 133
Cdd:COG1846  87 DPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-122 1.24e-19

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 77.63  E-value: 1.24e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832848     28 DLTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREHDAADKRRRFVWLTAEGEKILAAAIPIGD 107
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....*
gi 15832848    108 SVDEEFLGRLSAEEQ 122
Cdd:smart00347  87 ETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-86 9.23e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 48.35  E-value: 9.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15832848    28 DLTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREHDAADKRR 86
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 24-132 9.24e-05

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 39.60  E-value: 9.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832848   24 HELPDlTKPQYAVMRAIadkpGIEQVALieaaVSTkatlaemLARMENRGLVRREHDAADKRRRFVWLTAEGEKILAAAI 103
Cdd:PRK03573  41 HQLPP-EQSQIQLAKAI----GIEQPSL----VRT-------LDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVE 104

                         90       100
                 ....*....|....*....|....*....
gi 15832848  104 PIGDSVDEEFLGRLSAEEQELFVQLVRKM 132
Cdd:PRK03573 105 AVINKTRAEILHGISAEEIEQLITLIAKL 133
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-133 4.65e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.73  E-value: 4.65e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832848   2 TLRNKAFHQLRQLFQQHTARWQHEL--PDLTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREH 79
Cdd:COG1846   7 PAEERLGLLLRRLARALRRALDRALaeLGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15832848  80 DAADKRRRFVWLTAEGEKILAAAIPIGDSVDEEFLGRLSAEEQELFVQLVRKMM 133
Cdd:COG1846  87 DPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-122 1.24e-19

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 77.63  E-value: 1.24e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832848     28 DLTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREHDAADKRRRFVWLTAEGEKILAAAIPIGD 107
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....*
gi 15832848    108 SVDEEFLGRLSAEEQ 122
Cdd:smart00347  87 ETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-86 9.23e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 48.35  E-value: 9.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15832848    28 DLTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREHDAADKRR 86
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-85 2.03e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 47.54  E-value: 2.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15832848    29 LTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREHDAADKR 85
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
HTH_27 pfam13463
Winged helix DNA-binding domain;
29-95 7.53e-07

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 43.82  E-value: 7.53e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15832848    29 LTKPQYAVMRAI-ADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREHDAADKRRRFVWLTAEG 95
Cdd:pfam13463   1 LTRLEALILHNIgHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 24-132 9.24e-05

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 39.60  E-value: 9.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832848   24 HELPDlTKPQYAVMRAIadkpGIEQVALieaaVSTkatlaemLARMENRGLVRREHDAADKRRRFVWLTAEGEKILAAAI 103
Cdd:PRK03573  41 HQLPP-EQSQIQLAKAI----GIEQPSL----VRT-------LDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVE 104

                         90       100
                 ....*....|....*....|....*....
gi 15832848  104 PIGDSVDEEFLGRLSAEEQELFVQLVRKM 132
Cdd:PRK03573 105 AVINKTRAEILHGISAEEIEQLITLIAKL 133
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
28-133 3.46e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 38.34  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832848   28 DLTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREHDAADKRRRFVWLTAEGEKILAAAIP-IG 106
Cdd:PRK11512  37 DITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQlVG 116

                         90       100
                 ....*....|....*....|....*..
gi 15832848  107 DSVDEEFLGRLSAEEQELFVQLVRKMM 133
Cdd:PRK11512 117 QDLHQELTKNLTADEVATLEHLLKKVL 143
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
58-98 4.40e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 37.88  E-value: 4.40e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15832848  58 TKATLAEMLARMENRGLVRREhdaadkRRRFVWLTAEGEKI 98
Cdd:COG1321  37 SPPSVTEMLKKLEEKGLVEYE------PYGGITLTEEGREL 71
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 26-98 1.02e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 35.66  E-value: 1.02e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15832848  26 LPDLTKPQYAVMRAIADKPG-IEQVALIEAAVSTKATLAEMLARMENRGLVRREHDAadkRRRFVWLTAEGEKI 98
Cdd:COG2512  10 YPELLEDERRVLELLRENGGrMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVG---RENVVELPEDEPEA 80
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
33-103 3.45e-03

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 34.91  E-value: 3.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15832848  33 QYAVMRAIADKP--GIEQVALIEAAVSTKATLAE-----MLARMENRGLVRREHDAAD--KRRRFVWLTAEGEKILAAAI 103
Cdd:COG1695  11 ELLILALLAEGPmyGYEIIKELEERSGGFWKVSEgtlypALKRLEKEGLVESEWEESEggPRRKYYRLTEAGREELAEWL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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