type I-E CRISPR-associated protein Cas5/CasD is a component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity; Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly ...
5-154
3.62e-43
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex
:
Pssm-ID: 187886 Cd Length: 135 Bit Score: 142.68 E-value: 3.62e-43
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly ...
5-154
3.62e-43
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex
Pssm-ID: 187886 Cd Length: 135 Bit Score: 142.68 E-value: 3.62e-43
CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI; CRISPR is a term for Clustered, ...
3-232
8.03e-35
CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI; CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.
Pssm-ID: 273842 Cd Length: 216 Bit Score: 123.76 E-value: 8.03e-35
CRISPR-associated protein (Cas_Cas5); CRISPR is a term for Clustered, Regularly Interspaced ...
4-231
5.47e-23
CRISPR-associated protein (Cas_Cas5); CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum.
Pssm-ID: 430764 Cd Length: 215 Bit Score: 92.90 E-value: 5.47e-23
CRISPR/Cas system-associated protein Cas5, RAMP superfamily [Defense mechanisms]; CRISPR/Cas ...
3-152
2.24e-08
CRISPR/Cas system-associated protein Cas5, RAMP superfamily [Defense mechanisms]; CRISPR/Cas system-associated protein Cas5, RAMP superfamily is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 441294 Cd Length: 210 Bit Score: 52.78 E-value: 2.24e-08
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly ...
5-154
3.62e-43
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex
Pssm-ID: 187886 Cd Length: 135 Bit Score: 142.68 E-value: 3.62e-43
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly ...
5-154
6.54e-43
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex
Pssm-ID: 187776 Cd Length: 137 Bit Score: 142.30 E-value: 6.54e-43
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly ...
5-154
4.64e-36
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex
Pssm-ID: 187824 Cd Length: 202 Bit Score: 126.83 E-value: 4.64e-36
CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI; CRISPR is a term for Clustered, ...
3-232
8.03e-35
CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI; CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.
Pssm-ID: 273842 Cd Length: 216 Bit Score: 123.76 E-value: 8.03e-35
CRISPR-associated protein (Cas_Cas5); CRISPR is a term for Clustered, Regularly Interspaced ...
4-231
5.47e-23
CRISPR-associated protein (Cas_Cas5); CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum.
Pssm-ID: 430764 Cd Length: 215 Bit Score: 92.90 E-value: 5.47e-23
CRISPR-associated protein Cas5, N-terminal domain; This model represents a shared N-terminal ...
5-46
1.00e-09
CRISPR-associated protein Cas5, N-terminal domain; This model represents a shared N-terminal domain, about 43 amino acids in length, common to a number of related protein families each of which is associated with a distinct subtype of CRISPR/cas system, where CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeat and Cas is an abbreviation for CRISPR-associated. Members of this family are widely distributed enough that we designated the family Cas5. Homology appears remote, or absent, between the more C-terminal regions different subfamilies of these proteins, which typically are 210 to 265 amino acids in total length. Cas5 proteins of six different CRISPR/cas subtypes so far defined are described by respective full-length models TIGR01868, TIGR01876, TIGR01895, TIGR01874, TIGR02586, and TIGR02592. The best characterized protein in this family is DevS or Myxococcus xanthus, a Cas protein that appears to participate in a species-specific developmental pathway.
Pssm-ID: 274218 [Multi-domain] Cd Length: 42 Bit Score: 52.80 E-value: 1.00e-09
CRISPR/Cas system-associated protein Cas5, RAMP superfamily [Defense mechanisms]; CRISPR/Cas ...
3-152
2.24e-08
CRISPR/Cas system-associated protein Cas5, RAMP superfamily [Defense mechanisms]; CRISPR/Cas system-associated protein Cas5, RAMP superfamily is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 441294 Cd Length: 210 Bit Score: 52.78 E-value: 2.24e-08
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly ...
5-197
3.65e-04
CRISPR/Cas system-associated RAMP superfamily protein Cas5; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex
Pssm-ID: 187823 Cd Length: 189 Bit Score: 40.19 E-value: 3.65e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
Click on the triangle to view details about the feature, including a multiple sequence alignment
of your query sequence and the protein sequences used to curate the domain model,
where hash marks (#) above the aligned sequences show the location of the conserved feature residues.
The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
Click on the triangle for interactive 3D structure viewing options.
Functional characterization of the conserved domain architecture found on the query.
Click here to see more details.
This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
(labeled illustration) or all hits
(labeled illustration).
Domains are color coded according to superfamilies
to which they have been assigned. Hits with scores that pass a domain-specific threshold
(specific hits) are drawn in bright colors.
Others (non-specific hits) and
superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
with the same color and shade of the domain or superfamily that provides the annotation. Mouse over the colored bars or triangles to see descriptions of the domains and features.
click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
mapped to the query sequence.
Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
(CDART).
Modify your query to search against a different database and/or use advanced search options
