T3SS secreted effector EspL [Escherichia coli O157:H7 str. Sakai]
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
Toxin_15 super family | cl06788 | ShET2 enterotoxin, N-terminal region; The members of this family are are sequences that are ... |
21-266 | 6.28e-40 | |||||
ShET2 enterotoxin, N-terminal region; The members of this family are are sequences that are similar to the N-terminal half of the ShET2 enterotoxin produced by Shigella flexneri and Escherichia coli. This protein was found to confer toxigenicity in the Ussing chamber, and the N-terminal region was found to be important for the protein's enterotoxic effect. It is thought to be a hydrophobic protein that forms inclusion bodies within the bacterial cell, and may be secreted by the Mxi system. Most members of this family are annotated as putative enterotoxins, but one member is a regulator of acetyl CoA synthetase, and another two members (Swiss:P76205 and Swiss:P23325) are annotated as ankyrin-like regulatory proteins and contain Ank repeats (pfam00023). The actual alignment was detected with superfamily member pfam07906: Pssm-ID: 369588 Cd Length: 278 Bit Score: 146.19 E-value: 6.28e-40
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Name | Accession | Description | Interval | E-value | |||||
Toxin_15 | pfam07906 | ShET2 enterotoxin, N-terminal region; The members of this family are are sequences that are ... |
21-266 | 6.28e-40 | |||||
ShET2 enterotoxin, N-terminal region; The members of this family are are sequences that are similar to the N-terminal half of the ShET2 enterotoxin produced by Shigella flexneri and Escherichia coli. This protein was found to confer toxigenicity in the Ussing chamber, and the N-terminal region was found to be important for the protein's enterotoxic effect. It is thought to be a hydrophobic protein that forms inclusion bodies within the bacterial cell, and may be secreted by the Mxi system. Most members of this family are annotated as putative enterotoxins, but one member is a regulator of acetyl CoA synthetase, and another two members (Swiss:P76205 and Swiss:P23325) are annotated as ankyrin-like regulatory proteins and contain Ank repeats (pfam00023). Pssm-ID: 369588 Cd Length: 278 Bit Score: 146.19 E-value: 6.28e-40
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C58_PaToxP-like | cd20495 | peptidase C58 domain of Photorhabdus asymbiotica toxin PaTox and LifA/Efa1-related large ... |
113-155 | 5.60e-04 | |||||
peptidase C58 domain of Photorhabdus asymbiotica toxin PaTox and LifA/Efa1-related large cytotoxin, and similar proteins; This subfamily includes the cysteine protease domain of Photorhabdus asymbiotica toxin PaTox, a large virulence-associated multifunctional protein toxin. This domain is similar to AvrPphB protease found in Pseudomonas syringae, a C58 protease. Mutation studies show that this domain enhances cytotoxic effects of the toxin, and therefore is essential for full PaTox activity. Also included in this family is the enteropathogenic Escherichia coli (EPEC) factor for adherence/lymphocyte activation inhibitor (efa1/lifA) gene which is strongly associated with diarrhea. Efa1/LifA proteins are important for A/E lesion formation efficiency in EPEC strains lacking multiple effectors. This domain contains the invariant C/H/D residues conserved in the C58/YopT family. Pssm-ID: 410776 Cd Length: 179 Bit Score: 41.19 E-value: 5.60e-04
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Name | Accession | Description | Interval | E-value | |||||
Toxin_15 | pfam07906 | ShET2 enterotoxin, N-terminal region; The members of this family are are sequences that are ... |
21-266 | 6.28e-40 | |||||
ShET2 enterotoxin, N-terminal region; The members of this family are are sequences that are similar to the N-terminal half of the ShET2 enterotoxin produced by Shigella flexneri and Escherichia coli. This protein was found to confer toxigenicity in the Ussing chamber, and the N-terminal region was found to be important for the protein's enterotoxic effect. It is thought to be a hydrophobic protein that forms inclusion bodies within the bacterial cell, and may be secreted by the Mxi system. Most members of this family are annotated as putative enterotoxins, but one member is a regulator of acetyl CoA synthetase, and another two members (Swiss:P76205 and Swiss:P23325) are annotated as ankyrin-like regulatory proteins and contain Ank repeats (pfam00023). Pssm-ID: 369588 Cd Length: 278 Bit Score: 146.19 E-value: 6.28e-40
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C58_PaToxP-like | cd20495 | peptidase C58 domain of Photorhabdus asymbiotica toxin PaTox and LifA/Efa1-related large ... |
113-155 | 5.60e-04 | |||||
peptidase C58 domain of Photorhabdus asymbiotica toxin PaTox and LifA/Efa1-related large cytotoxin, and similar proteins; This subfamily includes the cysteine protease domain of Photorhabdus asymbiotica toxin PaTox, a large virulence-associated multifunctional protein toxin. This domain is similar to AvrPphB protease found in Pseudomonas syringae, a C58 protease. Mutation studies show that this domain enhances cytotoxic effects of the toxin, and therefore is essential for full PaTox activity. Also included in this family is the enteropathogenic Escherichia coli (EPEC) factor for adherence/lymphocyte activation inhibitor (efa1/lifA) gene which is strongly associated with diarrhea. Efa1/LifA proteins are important for A/E lesion formation efficiency in EPEC strains lacking multiple effectors. This domain contains the invariant C/H/D residues conserved in the C58/YopT family. Pssm-ID: 410776 Cd Length: 179 Bit Score: 41.19 E-value: 5.60e-04
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Blast search parameters | ||||
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