|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
22-431 |
5.40e-159 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 455.06 E-value: 5.40e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 22 KVLVASLIGTAIEFFDFYIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASL 101
Cdd:cd17369 2 RVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 102 LTMGISTVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTF 181
Cdd:cd17369 82 LLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 182 LLLSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIPLGTLLTKHVRVTVLGTFIMLATY 261
Cdd:cd17369 162 LLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAEN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 262 TLFYIMTVYSMTFSTAAapvgLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAFNPLLG 341
Cdd:cd17369 242 VLFYLFTTFALSYATQT----LGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 342 SGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQT-NYGLSAVGLYLAA 420
Cdd:cd17369 318 GSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAaTGSWWPVALYLAA 397
|
410
....*....|.
gi 15833657 421 MAGLTLIALLL 431
Cdd:cd17369 398 LAVISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
30-426 |
3.87e-151 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 434.39 E-value: 3.87e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 30 GTAIEFFDFYIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTV 109
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 110 VIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTFLLLSWLLT 189
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 190 DEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIPLGTLLTKHVRVTVLGTFIMLATYTLFYIMTV 269
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 270 YSMTFSTAAapvgLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAFNPLLGSGNPILVF 349
Cdd:TIGR00883 241 YLPTYLTQT----LGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15833657 350 AFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQTNYG-LSAVGLYLAAMAGLTL 426
Cdd:TIGR00883 317 FLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGdWYAIGYYLAALALIGL 394
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-438 |
1.08e-76 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 245.41 E-value: 1.08e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 1 MQATATTLDHEQEYTPINSRNKVLVASLIGTAIEFFDFYIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIG 80
Cdd:PRK09952 1 MDSTLISTRPDEGTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 81 SAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRA 160
Cdd:PRK09952 81 GVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 161 LYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFE--KVAKAKKQVKIP 238
Cdd:PRK09952 161 FYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEqqQHEQAAAKKRIP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 239 LGTLLTKHVRVTVLGTFIMLATYTLFYIMTVYSMTFSTAaapvGLGLPRNEVLWM-LMMAVIGFgVMVPVAGLLADAFGR 317
Cdd:PRK09952 241 VIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQ----NLGLPRELFLNIgLLVGGLSC-LTIPCFAWLADRFGR 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 318 RKsMVIITTLIILFALFAFNPLLGSGNP--ILVFAFLLLGLS--LMGLTFGPMgalLPELFPTEVRYTGASFSYNVASIL 393
Cdd:PRK09952 316 RR-VYITGALIGTLSAFPFFMALEAQSIfwIVFFSIMLANIAhdMVVCVQQPM---FTEMFGASYRYSGAGVGYQVASVV 391
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 15833657 394 GASVAPYIAAWLQTNYGLS--AVGLYLAAMAGLTLIALLLTHETRHQ 438
Cdd:PRK09952 392 GGGFTPFIAAALVTYFGGSwhSVAIYLLAGCLISAMTALLMKDNQRA 438
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
24-436 |
5.67e-74 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 237.58 E-value: 5.67e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 24 LVASLIGTAIEFFDFYIYATAAVIvFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLT 103
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALY-FAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 104 MGISTVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTFLL 183
Cdd:cd17367 80 MAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 184 LSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIPLGTLLtKHVRVTVLGTFIMLATYTL 263
Cdd:cd17367 160 LQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELR-RHPRELLLVVGLTAGGTLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 264 FYIMTVYSMTFSTAAApvglGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAFNPLLGSG 343
Cdd:cd17367 239 FYTWTTYLQKFLVNTA----GFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 344 NPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQTNYGLSAVGLYLAAMAG 423
Cdd:cd17367 315 SPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYVAGLIA 394
|
410
....*....|...
gi 15833657 424 LTLIALLLTHETR 436
Cdd:cd17367 395 ISLVVYLRMPETR 407
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
22-440 |
2.35e-66 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 219.97 E-value: 2.35e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 22 KVLVASLIGTAIEFFDFYIYATAAvIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASL 101
Cdd:PRK10642 16 KAITAASLGNAMEWFDFGVYGFVA-YALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 102 LTMGISTVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTF 181
Cdd:PRK10642 95 VIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 182 LLLSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVF---------EKVAKAKKQVKIPLGTLLTKHVRVTVL 252
Cdd:PRK10642 175 VLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFqqhvdkleqGDREGLQDGPKVSFKEIATKHWRSLLT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 253 GTFIMLATYTLFYIMTVYSMTFSTAaapvGLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFA 332
Cdd:PRK10642 255 CIGLVIATNVTYYMLLTYMPSYLSH----NLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVLA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 333 LFAFNpLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVaSILGASVAPYIAAWL-QTNYGL 411
Cdd:PRK10642 331 IPAFI-LINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNI-SVLVAGLTPTLAAWLvESTQNL 408
|
410 420
....*....|....*....|....*....
gi 15833657 412 SAVGLYLAAMAGLTLIALLLTHETRHQSL 440
Cdd:PRK10642 409 MMPAYYLMVVAVIGLITGVTMKETANRPL 437
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
25-435 |
1.69e-64 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 211.83 E-value: 1.69e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 25 VASLIGTAIEFFDFYIYATAAVIVfPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTM 104
Cdd:cd17366 2 KAAALGNAMEWFDFGVYGYLAVTI-GKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 105 GISTVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTFLLL 184
Cdd:cd17366 81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 185 SWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLhespvfekvakakkqvkiplgtlltkhvrvtVLGTFIMLATYTLF 264
Cdd:cd17366 161 TLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRPL-------------------------------LICIGLVLVFNVTN 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 265 YIMTVYSMTFSTAAapvgLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAFNpLLGSGN 344
Cdd:cd17366 210 YMLLSYMPSYLEET----LGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFL-LMNSGS 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 345 PILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQTNYGLSAV-GLYLAAMAG 423
Cdd:cd17366 285 IAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMpAYYLMVAAV 364
|
410
....*....|..
gi 15833657 424 LTLIALLLTHET 435
Cdd:cd17366 365 VGLVAVLFLTET 376
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
26-435 |
1.39e-62 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 208.00 E-value: 1.39e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 26 ASLIGTAIEFFDFYIYATAAVIVfPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMG 105
Cdd:cd17368 3 AATSGNALEFFDFGVYGFFAVYI-GRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 106 ISTVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTFLLLS 185
Cdd:cd17368 82 LGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 186 WLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKipLGTLLTKHVRVTVLGTFIMLATYTLFY 265
Cdd:cd17368 162 LTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRE--LFALLANNRRIILLGMLLVAGSTVTFY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 266 IMTVYSMTFSTAAapvgLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAFNPLLGSGNP 345
Cdd:cd17368 240 FTTVYTPTYAKTV----LGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 346 ILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQTNYG-LSAVGLYLAAMAGL 424
Cdd:cd17368 316 GRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGsPLAPAWYLMGAALL 395
|
410
....*....|.
gi 15833657 425 TLIALLLTHET 435
Cdd:cd17368 396 GLLATLMLRET 406
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
1-433 |
5.43e-55 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 188.48 E-value: 5.43e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 1 MQATATTLDHEQEYTPINSRNKVLVASLIGTAIEFFDFYIYATAAvIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIG 80
Cdd:PRK10406 1 MAESTVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCS-LYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 81 SAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRA 160
Cdd:PRK10406 80 GWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 161 LYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKqvkiplG 240
Cdd:PRK10406 160 FYASFQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEA------G 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 241 TL--LTKHVRvtvlgTFIMLATYTL-----FYIMTVYSMTFSTAAApvglGLPRNEVLWMLMMAVIGFGVMVPVAGLLAD 313
Cdd:PRK10406 234 SLkgLWRNRR-----AFIMVLGFTAagslcFYTFTTYMQKYLVNTA----GMHANVASGIMTAALFVFMLIQPLIGALSD 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 314 AFGRRKSMVIITTLIILFALFAFNPLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASIL 393
Cdd:PRK10406 305 KIGRRTSMLCFGSLAALFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAL 384
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 15833657 394 GASVAPYIAAWLQTNYGLSAVGLYLAAMAGLTLIALLLTH 433
Cdd:PRK10406 385 FGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLH 424
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-430 |
8.57e-47 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 164.70 E-value: 8.57e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 24 LVASLIGTAIEFFDFYIYATAAVIVFPHIffpqgDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLT 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 104 MGISTVVIGLLPGyatigifaPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFAngtfLL 183
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA----AL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 184 LSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRvslhespvfekvakakkqvkiplgtlltkhvRVTVLGTFIMLATYTL 263
Cdd:cd17316 144 VASLLIPLLSGDWGWRILFLIGALPALLALLLR-------------------------------RRTLLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 264 FYIMTVYSMTFSTAaapvGLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAFnpLLGSG 343
Cdd:cd17316 193 YYGLTTFLPTYLQT----VLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF--YLLSG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 344 NPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQTNYGLSAVGLYLAAMAG 423
Cdd:cd17316 267 SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
....*..
gi 15833657 424 LTLIALL 430
Cdd:cd17316 347 VALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
30-440 |
5.68e-44 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 159.34 E-value: 5.68e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 30 GTAIEFFDFYI---YATAavivFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGI 106
Cdd:PRK15075 23 GNFLEMFDFFLfgfYATA----IAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 107 STVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTFLLLSW 186
Cdd:PRK15075 99 GTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 187 LLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIpLGTLLtKHVRVTVLGTFIMLATYTLFYI 266
Cdd:PRK15075 179 WLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMREI-FRSLA-ANWRIVLAGMLMVAMTTVSFYL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 267 MTVYSMTFSTAAapvgLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAFNPLLGS---G 343
Cdd:PRK15075 257 ITVYTPTFGKTV----LHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILTAYPALSWLVAApsfA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 344 NPILV---FAFLLLGLSlmgltfGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQTNYG-LSAVGLYLA 419
Cdd:PRK15075 333 RMLAVelwLSFLYGSYN------GAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGdKAAPGYWLS 406
|
410 420
....*....|....*....|.
gi 15833657 420 AMAGLTLIALLLTHETRHQSL 440
Cdd:PRK15075 407 FAAVCGLIATLVLYRRRGARL 427
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
24-436 |
7.69e-26 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 108.16 E-value: 7.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 24 LVASLIGTAIEFFDFYIYATAAVIVFPHiffpqGDPTAATLQSLATFAIAFVArpIGSAVFGHFGDRVGRKATLVASLLT 103
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAE-----FGLDEAEAGLLGTVTLAGGA--IGGILGGILADRFGRVRVLVITILL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 104 MGISTVVIGLLPGYATigifapllLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANG-TFL 182
Cdd:cd17371 74 FAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLlAAL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 183 LLSWLLTDeqfmsWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIP--LGTLLTKHVRVTVLGTFIMLAT 260
Cdd:cd17371 146 LFPLLPPE-----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRpsLRELFSPPLLRTTLLASLLATG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 261 -YTLFYIMTVYSMTFSTAAapvgLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVI------ITTLIILFAL 333
Cdd:cd17371 221 aLGGYYGITTWLPSYLTGE----RGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALfalgsaISILLYFFLP 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 334 FAFNPLLGSGNPILVFAFLLlglslmgltFGPMGALLPELFPTEVRYTGASFSYNVASILGAsVAPYIAAWLQTNYGLSA 413
Cdd:cd17371 297 LSPTLILILGFPLGFFASGP---------FSGMGAYLTELFPTAVRATAQGFCYNVGRIIGA-LFPFLVGFLATSGSLGT 366
|
410 420
....*....|....*....|...
gi 15833657 414 VGLYLAAMAGLTLIALLLTHETR 436
Cdd:cd17371 367 AIAVFAAVYYIAGLVLALLLPET 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-431 |
2.90e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.55 E-value: 2.90e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 15 TPINSRNKVLVASLIGTAIEFFDFYIYATAAVIVFPHIFFpqgdpTAATLQSLatFAIAFVARPIGSAVFGHFGDRVGRK 94
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGL-----SAAQLGLL--ASAFFLGYALGQIPAGLLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 95 ATLVASLLTMGISTVVIGLLPGYAtigifaplLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGF 174
Cdd:COG2271 76 RVLAIGLLLWGLATLLFGFATSFW--------QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 175 FFANgtfLLLSWLLTdeqfmSWGWRVPFIFSAVLVIIglyvrvslhespvfekvakakkqvKIPLGTLLTKHVRVTVLGT 254
Cdd:COG2271 148 ALAP---PLLGWLLA-----AFGWRAAFLILGLPGLL------------------------LALLRFWLLALAYFLVYFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 255 FIMLATYTLFYIMTVYSMTFSTAAapvglglprnevlWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALF 334
Cdd:COG2271 196 LYGFLTWLPTYLVEVRGLSLAQAG-------------LLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALAL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 335 AFNPLLGSgnPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFsYNVASILGASVAPYIAAWLQTNYGLSAV 414
Cdd:COG2271 263 LLLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
410
....*....|....*..
gi 15833657 415 GLYLAAMAGLTLIALLL 431
Cdd:COG2271 340 FLLLAALALLAALLALL 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-433 |
1.02e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 87.63 E-value: 1.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 18 NSRNKVLVASLIGTAIEFFDFYIYATAAVIVFPHIFFpqgdpTAATLQSLatFAIAFVARPIGSAVFGHFGDRVGRKATL 97
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGL-----SAAQLGLL--FAIPVLVGALLRIPLGFLVDRFGPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 98 VASLLTMGISTVVIGLLPGYAtigifaplLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFA 177
Cdd:COG2223 74 LIGLLLLGIGLLLLALAVSYW--------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 178 NgtfLLLSWLLTdeqfmSWGWRVPF-IFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKiPLGTLLTKHVRVTVL---- 252
Cdd:COG2223 146 A---FLAPLLIA-----AFGWRNAFlILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD-QLEALRDPRFWLLSLlyfg 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 253 --GTFIMLATYTLFYIMTVYSMTFSTAAAPVGLGlprnevlwmlmmaVIGFGVMVPVAGLLADAFGRRKSMVIITTLIIL 330
Cdd:COG2223 217 tfGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF-------------ALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 331 FALFAFNPLlgsGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYnVASILGASVAPYIAAWLQTNYG 410
Cdd:COG2223 284 GLLLLALAL---GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVG-AAGGLGGFLGPLLFGALLDATG 359
|
410 420
....*....|....*....|...
gi 15833657 411 LSAVGLYLaaMAGLTLIALLLTH 433
Cdd:COG2223 360 SYTAAFLV--FAVLALVALVLTL 380
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
22-440 |
9.69e-18 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 85.02 E-value: 9.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 22 KVLVASLIGTaIEFFDFYIYATAAVIVFPHIFFPQ----GDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATL 97
Cdd:pfam00083 1 VALVAALGGF-LFGYDTGVIGAFLTLIDFFKNFGLsksvSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 98 VASLLTMGISTVVIGLLPGYATIGifaplLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFA 177
Cdd:pfam00083 80 LIANVLFVIGAVLQGAAKGKWSVY-----QLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 178 NGTFlllswLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVF-------------------------------E 226
Cdd:pfam00083 155 YIFG-----LGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWlvekgrleearevlaklrgvpdvdreldeikD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 227 KVAKAKKQVKIPLGTLLTKHVRVTVLGTFIMLATYTLF----YIMTVYSMTFSTAaapvglgLPRNEVLWMLMMAVIGFg 302
Cdd:pfam00083 230 SLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLtginAIFYYSTTIFENL-------GLSDSFLVTIIVGVVNF- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 303 VMVPVAGLLADAFGRRKS-MVIITTLIILFALFAFNPLLG----SGNPILVFAFLLLGLSLMGLTFGPMGA-LLPELFPT 376
Cdd:pfam00083 302 VFTFIAIFLVDRFGRRPLlLLGAAGMAICFVILGIVALLGvsksDWAGIVAIVFIALFIAFFAMGWGPVPWvIVSELFPL 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15833657 377 EVRYTGASFSYNvASILGASVAPYIAAWLQTNYGLSAVGLYLAA-MAGLTLIALLLTHETRHQSL 440
Cdd:pfam00083 382 SVRSKAMALATA-ANWLANFLIGFLFPIITDAIGLGYTFFIFAGlLVLFIIFVFFFVPETKGRTL 445
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-326 |
1.04e-17 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 83.32 E-value: 1.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 11 EQEYTPINSRNKVLVASLIGTAIEFFDFYIYATAAVIVfphiffpQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDR 90
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSI-------AADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 91 VGRKATLVASLLTMGISTVVIGLLPGyatigifaPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGA 170
Cdd:COG0477 76 YGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 171 PIGFFFANGTFLLLSWLltdeqfmsWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIPLGTLLTKHVRVT 250
Cdd:COG0477 148 GLGLALGPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALL 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15833657 251 VLGTFIMLATYTLFYIMTVYSMTFSTAAAPVGLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITT 326
Cdd:COG0477 220 LLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-395 |
8.68e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.40 E-value: 8.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 15 TPINSRNKVLVASLIGTAIEFFDFYIYATAAVIVfphiffpQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRK 94
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLI-------AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 95 ATLVASLLTMGISTVVIGLLPGYAtigifaplLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGF 174
Cdd:COG2814 76 RVLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 175 FFAngtFLLLSWLLTdeqfmSWGWRVPFIFSAVLVIIGLY-VRVSLHESPVFEKVAKAKKQVKIplgtLLTKHVRVTVLG 253
Cdd:COG2814 148 ALG---PLLGGLLAD-----LFGWRWVFLVNAVLALLALLlLLRLLPESRPAARARLRGSLREL----LRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 254 TFIMLATYTLFYimtvysmTFSTAAAPVGLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFAL 333
Cdd:COG2814 216 AFLLGFGFFALF-------TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15833657 334 FafnpLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGA 395
Cdd:COG2814 289 L----LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
22-431 |
1.71e-14 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 75.12 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 22 KVLVASLIGTAIEFFDFYIYAtaavIVFPHIF--FPQGDPTAATLQSlatfaIAFVARPIGSAVFGHFGDRVGRKATLVA 99
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLIT----LVLTEVQgeFGLTTVQAASLIS-----AAFISRWFGGLLLGAMGDRYGRRLAMVI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 100 SLLTMGISTVVIGLLPGYATIGIFaplllalaRFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANg 179
Cdd:PRK03893 91 SIVLFSVGTLACGFAPGYWTLFIA--------RLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAA- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 180 tfLLLSWLLTdeqfmSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIPLGTLLTKHVRV--TVLGTFIM 257
Cdd:PRK03893 162 --QVYSLVVP-----VWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTMVDILYRGEHRIinILLTLAAA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 258 LATYTLFYIMT-----VYSMTFSTAAAPVGLGLPRNEVLW----MLMMAVI----------------------------- 299
Cdd:PRK03893 235 AALWFCFAGNLqnaaiVAVLGLLCAAIFISFMVQSSGKRWptgvMLMVVVLfaflyswpiqallptylktdlgydphtva 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 300 ------GFGVMVP--VAGLLADAFGRRKSMV--IITTLIILFALFAfnplLGSGNPILVFAFLLLGLSLMGLTFGPMGAL 369
Cdd:PRK03893 315 nvlffsGFGAAVGccVGGFLGDWLGTRKAYVcsLLISQLLIIPVFA----IGGANVWVLGLLLFFQQMLGQGISGLLPKL 390
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15833657 370 LPELFPTEVRYTGASFSYNVASiLGASVAPYIAAWLQTNYGLsavGLYLAAMA-GLTLIALLL 431
Cdd:PRK03893 391 IGGYFDTEQRAAGLGFTYNVGA-LGGALAPILGALIAQRLDL---GTALASLSfSLTFVVILL 449
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
14-430 |
3.24e-13 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 71.11 E-value: 3.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 14 YTPINS-RNKVLVASLIGTAIEFFDFyiyataaVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVG 92
Cdd:PRK12307 9 YSEITRpQKNALFSAWLGYVFDGFDF-------MLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 93 RKATLVASLLTMGISTVVIGLLPGYatigifapLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPI 172
Cdd:PRK12307 82 RKPLMMWSIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 173 GFFFAngtflllswlltdEQFM-----SWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKkqvkipLGTLLTKHV 247
Cdd:PRK12307 154 GNIIA-------------AYFMpsfaeAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSG------KGKHSQSAW 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 248 RVTVLGTFIMLATYTLFYIMTVYSMTFSTAAA--PVGLGLPR-------NEVLWMLMMAVIGFGVMVP--VAGLLADAFG 316
Cdd:PRK12307 215 SVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGAnwPIFGLLPTylagegfDTGVVSNLMTAAAFGTVLGniVWGLCADRIG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 317 RRKSMVI--ITTLIILFALFafnpLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASIlG 394
Cdd:PRK12307 295 LKKTFSIglLMSFLFIFPLF----RIPQDNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAAT-S 369
|
410 420 430
....*....|....*....|....*....|....*.
gi 15833657 395 ASVAPYIAAWLQTNYGLSAVGLYLAAMAGLTLIALL 430
Cdd:PRK12307 370 GTFNSMAATWLGITMGLGAALTFIVAFWTATILLII 405
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
70-431 |
7.41e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 7.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 70 FAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYAtigifaplLLALARFGQGLGLGGEWGGAALL 149
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 150 ATENAPPRKRALYGSFPQLGAPIGFFFAngtfLLLSWLLTDeqfmSWGWRVPFIFSAVLVIIGLYVRVS-LHESPVFEKV 228
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIG----PLLGGLLAD----ALGYRAPFLVCAALALLALVLALLlLPEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 229 AKAKKQVKIPLGTLLTKHVRVTVLGTFIMLatytLFYIMTVYSMTFSTAAAPVGlGLPRNEVLWMLMMAVIGFGVMVPVA 308
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRLLALFLAIFV----LAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 309 GLLADAFGRRKsmVIITTLIILFALFAFNPLlgSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRytGASFS-Y 387
Cdd:cd17325 256 GKLSDRIGRKP--LILIGLLLSAVALLLLPL--ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGR--GTAMGlF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15833657 388 NVASILGASVAPYIAAWLQTNYGLSAVGLYLAAMAGLTLIALLL 431
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
70-431 |
1.93e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.83 E-value: 1.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 70 FAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGyatigifaPLLLALARFGQGLGLGGEWGGAALL 149
Cdd:cd17365 40 GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--------VLQLALLRFLTGLGLGAAMPNAITL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 150 ATENAPPRKRALYGSFPQLGAPIGfffANGTFLLLSWLLTdeqfmSWGWRVPFIFSAVLVIIGLyvrvslhespvfekva 229
Cdd:cd17365 112 VSEYAPARRRSLAVTLMFCGYPLG---AALGGFLAAALIP-----AFGWRSVFLLGGVPPLILL---------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 230 kakkqvkiplgtlltkhvrVTVLGTFIMLATYTLFYIMtVYSMTFSTAAAPVGLGLPRNEVLWMLMMAVIGFGVMVPVAG 309
Cdd:cd17365 168 -------------------PLLRGTLLLWVTFFMGLLL-VYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 310 LLADAFGRRKSMVIIttlIILFALFAFNPLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSyNV 389
Cdd:cd17365 228 WLADRFGPKRVLALF---FALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWA-LG 303
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15833657 390 ASILGASVAPYIAAWLQTNyGLSAVGLYLAAMAGLTLIALLL 431
Cdd:cd17365 304 VGRLGAILGPLLGGLLLAA-GLGPESVFLALAIPAALGALAV 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
79-430 |
2.29e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.80 E-value: 2.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 79 IGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYAtigifaplLLALARFGQGLGLGGEWGGAALLATENAPPRK 158
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 159 RALYGSFPQLGAPIGFFFAngtfLLLSWLLTDeqfmSWGWRVPFIFSAVL-VIIGLYVRVSLHESPVFEKVAKAKKQVki 237
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLG----RPLGGLLGQ----LLGWRAAFLAIAVLaLLAALLLWRLLPSLPPKKPGSLGLLSS-- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 238 PLGTLLTKHVRVTVLGTFIMLATYTLFYIMTVYSMTFSTaaapvglGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGR 317
Cdd:cd17324 191 LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVP-------GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 318 RKSMVIITTLIILFALFafnpLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPtEVRYTGASFsYNVASILGASV 397
Cdd:cd17324 264 RALLIALLLLAAALLLL----TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSL-YLAAYNLGGAL 337
|
330 340 350
....*....|....*....|....*....|...
gi 15833657 398 APYIAAWLQTNYGLSAVGLYLAAMAGLTLIALL 430
Cdd:cd17324 338 GAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
62-405 |
3.07e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 61.60 E-value: 3.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 62 ATLQSLATFAIAFVArpIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATIGIFaplllalaRFGQGLGLGG 141
Cdd:TIGR00895 52 VQLGFLFSAGLIGMA--FGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL--------RFLAGLGLGG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 142 EWGGAALLATENAPPRKRALYGSFPQLGAPIGfffANGTFLLLSWLLTDeqfmsWGWRVPFIFSAVL-VIIGLYVRVSLH 220
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIG---AAVGGFLAGWLIPV-----FGWRSLFYVGGIApLLLLLLLMRFLP 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 221 ESPVFEKVAKAKKQVKIPLGTLLTKHVRV-------------------------TVLGTFIMLATYtLFYIMTVYSMTFS 275
Cdd:TIGR00895 194 ESIDFLVSKRPETVRRIVNAIAPQMQAEAqsalpeqkstqgtkrsvfkalfqgkTARITVLLWLLY-FMLLVGVYFLTNW 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 276 TAAAPVGLGLPRNEVLwmLMMAVIGFGVMVP--VAGLLADAFGRRKSMViittLIILFALFAFNPLLGSGNPILVFAFLL 353
Cdd:TIGR00895 273 LPKLMVELGFSLSLAA--TGGALFNFGGVIGsiIFGWLADRLGPRVTAL----LLLLGAVFAVLVGSTLFSPTLLLLLGA 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15833657 354 LGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASiLGASVAPYIAAWL 405
Cdd:TIGR00895 347 IAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGR-LGAIIGPILAGYL 397
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
83-431 |
8.94e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.22 E-value: 8.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 83 VFGHFGDRVG-----RKATLVASLLTMGISTVVIGLLPGYATIGIFAPLLLALArFGQGLGLGGEWGGAALLATENAPPR 157
Cdd:COG2211 65 LIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYL-LLGLAYTLVNIPYSALGAELTPDYE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 158 KRALYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQFMSWGWrVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVki 237
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRL-TALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES-- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 238 pLGTLLT-KHVRVTVLGTFIMLATYTLFYIMTVYSMTFStaaapvgLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFG 316
Cdd:COG2211 221 -LKALLKnRPFLLLLLAYLLFFLALALVAALLLYYFKYV-------LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 317 RRKSMVIITTLIILFALFAFnpLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFP-----TEVRYTGASFS-YNVA 390
Cdd:COG2211 293 KKKAFIIGLLLAALGLLLLF--FLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewkTGRRREGLYFGiFTFA 370
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15833657 391 SILGASVAPYIAAWLQTNYGLSA-VGLYLAAMAGLTLIALLL 431
Cdd:COG2211 371 IKLGQALAGALAGLLLALFGYVAgAAQSPSALTGIRLLFFLL 412
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
70-399 |
9.36e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 56.66 E-value: 9.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 70 FAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYatigifapLLLALARFGQGLGLGGEWGGAALL 149
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--------WLLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 150 ATENAPPRKRALYGSFPQLGAPIGFFFAngtFLLLSWLLTdeqfmSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVA 229
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALG---PLLGGLLAS-----LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 230 KAKKQVKIPLGTLLTKHVRVTVLGTFIMLATYTLFYIMTVYSMTFSTaaapvGLGLPRNEVLWMLMMAVIGFGVMVPVAG 309
Cdd:pfam07690 182 PAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-----VLGLSALLAGLLLGLGGLLGAIGRLLLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 310 LLADAFGRRKSMVIITTLIILFALFAFnPLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFsYNV 389
Cdd:pfam07690 257 RLSDRLGRRRRLLLALLLLILAALGLL-LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL-YNT 334
|
330
....*....|
gi 15833657 390 ASILGASVAP 399
Cdd:pfam07690 335 AGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
83-433 |
1.04e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 83 VFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATI-------GIFAPLLLALArfgqglglggeWGGAALLATENAP 155
Cdd:cd17474 53 VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLlagralqGIGAAGLGPLA-----------LTLIGDLFEGGER 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 156 PRKRALYGSFpqLGAPIGFFFANGTFLLLswlltdeqfmsWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQV 235
Cdd:cd17474 122 AKAMGLYEAA--LGLGIAVGPLLGGLLAA-----------ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 236 KIPLGTLLTKHVRVTVLGTFIMLATY--TLFYIMTVYSMTFSTAAAPVGLGLprneVLWMLMMAVIGFGvmvpVAGLLAD 313
Cdd:cd17474 189 RDLKKALRGRGLLTFLVSAFLYFFLYfaFLTYLPFLLELLYGISPIIIGLLF----AGWSVLLALGSLF----VGRLLKK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 314 AFGRRKSMVI-ITTLIILFALFAFNPllgsgNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTgASFSYNVASI 392
Cdd:cd17474 261 RFGARRILVIgLLLYALSLLLLGFVP-----SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT-ASSLYNFVRF 334
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15833657 393 LGASVAPYIAAWLQTNYGLSAVglyLAAMAGLTLIALLLTH 433
Cdd:cd17474 335 LGQAVGPLLFGLLLEIFGLSAP---FLVGAAIALAAAVLLA 372
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
69-432 |
1.73e-08 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 55.66 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 69 TFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYAtigifaplLLALARFGQGLGLGGEWGGAAL 148
Cdd:cd17317 30 VQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 149 LATENAPPRKRALYGSFpqlgapIGFFFANGTFLL--LSWLLTDEQFMSWGWRVPFIFSAVLviiglyvrvslhespvfe 226
Cdd:cd17317 102 LGMEIVGPKYRSFVGIL------FGLFWALGYMLLalLAYLIRDWRWLQLAISLPGLLFLLL------------------ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 227 kvakakkQVKIPlgtlltkhvRVTVLGTFIMLATYTLFYIMTVYSMTFStaaapvglglpRNEVLWMLMMAVIGFgVMVP 306
Cdd:cd17317 158 -------LWWLP---------RRTIIVGLIWFVTSLVYYGLSLNSSNLG-----------GNLYLNFFLSGLVEI-PAYF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 307 VAGLLADAFGRRKSMviITTLIILFALFAFNPLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFS 386
Cdd:cd17317 210 LALLLLDRLGRRWTL--SGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLC 287
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15833657 387 yNVASILGASVAPYIAAWLQTNYGLSAVglylaAMAGLTLIALLLT 432
Cdd:cd17317 288 -STVARVGAILAPFIVLLGKIGPLLPLI-----IFGVLALLGGLLT 327
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
35-430 |
3.68e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 55.13 E-value: 3.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 35 FFDFYIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLL 114
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 115 PGYatigifapLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFAngtFLLLSWLLTdeqFM 194
Cdd:cd06174 82 PSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILG---PLLGGILAS---SL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 195 SWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIPLGTLLTKHVRVtvLGTFIMLATYTLFYIMTVYSMTF 274
Cdd:cd06174 148 GFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKN--PGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 275 STAAAPVGLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAfnpLLGSGNPILVFAFLLL 354
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLAL---LLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15833657 355 GLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQTNYGLSAVGLYLAAMAGLTLIALL 430
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
79-386 |
7.28e-08 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 54.12 E-value: 7.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 79 IGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATigifapllLALARFGQGLGLGGEWGGAALLATENAPPRK 158
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 159 RALYGSFPQLGAPIGFFFANGTFLLLSwlltdeQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFekvakakkqvkip 238
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLALS------LSPPGWWRLMFALAAVPALLQLLLMFFLPESRAL------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 239 lgtlltkhvrVTVLGTFIMLA----TYTLFYIMTVYSMTFSTAAAPVGlglprNEVLWMLMMavigfgVMVPVAGLLADA 314
Cdd:cd17315 182 ----------LVGVGLQLLQQltgiNAVMYYAPTIFKSAGGGTASILA-----SIIVGVVNL------LATLVAIRLVDK 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15833657 315 FGRRK----SMVIITTLIILFALFAFNPLLGSGNPILVFAFLLLGLSLMGLTFGPMGALL-PELFPTEVRYTGASFS 386
Cdd:cd17315 241 VGRRPllliGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLlSEIFPLRIRGKGMAIA 317
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
23-225 |
2.18e-06 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 49.65 E-value: 2.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 23 VLVASLIGTAIEFFDF---YIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKAtlva 99
Cdd:TIGR00879 27 ALLSLIAAIGGLMFGYdtgVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKK---- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 100 SLLTMGISTVVIGLLPGYATIGiFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANG 179
Cdd:TIGR00879 103 SLLIIALLFVIGAILMGLAAFA-LSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYG 181
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 15833657 180 -TFLLLSWLLTDeqfmswGWRVPFIFSAVLVIIGLYVRVSLHESPVF 225
Cdd:TIGR00879 182 fGSGKVSLNNTL------GWRIPLGLQLIPAGLLFLGLFFLPESPRW 222
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
59-386 |
2.42e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 49.49 E-value: 2.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 59 PTAATLQSLATfAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATigifapllLALARFGQGLG 138
Cdd:cd17359 32 NLTPFLEGLVV-SSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTI--------FIIARIIGGLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 139 LGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVS 218
Cdd:cd17359 103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 219 LHESPVFekvakakkqvkiplgtLLTKHVRVTVLGtfIMLATY--------TLFYIMTVY-SMTFSTAAApvglglprne 289
Cdd:cd17359 183 IPESPRW----------------LVSKGKPILIIG--IGLAIFqqfvginvIFYYGPEIFqNAGFSENAA---------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 290 vlwmlMMAVIGFGV----MVPVAGLLADAFGRRKSMVI-----ITTLIILFALFAFNPLLGSgNPILVFAFLLLGLSLMG 360
Cdd:cd17359 235 -----LLQTIGIGVvnviFTIIAILLVDKVGRKPLLLIgsigmAISLLLIGTAFYFAPGSQA-SGIVALVLILLFVAFFA 308
|
330 340
....*....|....*....|....*..
gi 15833657 361 LTFGP-MGALLPELFPTEVRYTGASFS 386
Cdd:cd17359 309 MSWGPvTWVLLSEIFPNRIRGLAMGIA 335
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
80-429 |
8.66e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 47.65 E-value: 8.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 80 GSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATigifapllLALARFGQGLGLGGEWGGAALLATENAPPRKR 159
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 160 ALYGSFPQLGAPIGFFFANgtflLLSWLLTDEQfmswGWRVPFIFSAV--LVIIGLYVRVsLHESPVFEKVAKAKKQVKI 237
Cdd:PRK11551 138 GTAVSLMYCGVPFGGALAS----VIGVLAAGDA----AWRHIFYVGGVgpLLLVPLLMRW-LPESRAFAQAAGAGKQRAP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 238 PLGTLLTKHVRVTVLGTFI-MLATYTLFYIMTVY--SMTfstaaapVGLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADA 314
Cdd:PRK11551 209 VLRALFGEGRATATLLLWIsYFFTLIVLYFLLNWlpSLL-------VGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDR 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 315 FGRRKsMVIITTLIILFALFAFNpLLGSGNPILVFAFLLLGLSLMGLTFgpMGALLPELFPTEVRYTGASFSYNVASiLG 394
Cdd:PRK11551 282 LRPRR-VVLLIYAGILASLAALA-AAPSFAGMLLAGFAAGLFVVGGQSV--LYALAPLFYPTQVRGTGVGAAVAVGR-LG 356
|
330 340 350
....*....|....*....|....*....|....*
gi 15833657 395 ASVAPYIAAWLqTNYGLSAVGLYLAAMAGLTLIAL 429
Cdd:PRK11551 357 SMAGPLLAGQL-LALGRSTVGVIGASIPVILVAAL 390
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
79-440 |
3.02e-05 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 45.81 E-value: 3.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 79 IGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYAtigifaplLLALARFGQGLGLGGEWGGAALLATENAPPRK 158
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 159 RALYGSFPQLGAPIGfffangtflLLSWLLTDEQFMS--WGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKvakakkqvk 236
Cdd:cd17362 126 RGLLVSLKELFIVLG---------ILLGYVSGYAFADvvGGWRYMYGLAAPPALLLGIGMWFLPPSPRWQG--------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 237 iplgtlltKHVRVTVLGTFIMLATY------TLFYIMTVY-SMTFSTAA----APVGLGlprnevLWMLMMAVigfgvmv 305
Cdd:cd17362 188 --------NYRKPLIIGLGLVLFQQitgqpsVLYYAATIFkSAGFSAASdatlVSVGLG------VFKLLMTI------- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 306 pVAGLLADAFGRRK-----SMVIITTLIILFALFAFNPLLGSGNPILVFAFLLLGLSLMGLTFGPMGAL-LPELFPTEVR 379
Cdd:cd17362 247 -VAVLLVDKLGRRPlllggVSGMVVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQISFGPISWLmVSEIFPLRVR 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15833657 380 YTGASFSYNVASILGASVAPYIAAwLQTNYGLSAVGLYLAAMAGLTLIALLLT-HETRHQSL 440
Cdd:cd17362 326 GRAIALAVLVNFGSNALVSLAFLP-LQELIGLPGTFLGFGVIGVLALLFIYFTvPETKGLSL 386
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
69-432 |
3.87e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.78 E-value: 3.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 69 TFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATIGIFaplllalaRFGQGLGLGGEWGGAAL 148
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--------RLLVGMGIGGIWVQAVV 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 149 LATENAPPRKRALYGSFpqlgapIGFFFANGTFLL--LSWLLTDEQFMSWGWRVPFIFSAVLVIIglyvrvsLHESPVFE 226
Cdd:TIGR00898 204 LNTEFLPKKQRAIVGTL------IQVFFSLGLVLLplVAYFIPDWRWLQLAVSLPTFLFFLLSWF-------VPESPRWL 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 227 KV-------------AKAKKQVKIPLGTL---LTKHVRVTVLGTFIM-------LATYTLFYIMTVYSMTFSTAAAPVGL 283
Cdd:TIGR00898 271 ISqgrieealkilqrIAKINGKKLPAEVLslsLEKDLSSSKKQYSFLdlfrtpnLRKTTLCLMMLWFTTAFSYYGLVLDL 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 284 G-LPRNEVLWMLMMAVIGFGVMVpVAGLLADAFGRRKSMVIITTLIILFALFAFnpLLGSGNPILVFAFLLLGLSLMGLT 362
Cdd:TIGR00898 351 GnLGGNIYLDLFISGLVELPAKL-ITLLLIDRLGRRYTMAASLLLAGVALLLLL--FVPVDLYFLRTALAVLGKFGITSA 427
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 363 FGPMGALLPELFPTEVRYTGASFSyNVASILGASVAPYIAAWLQTNyglsaVGLYLAAMAGLTLIALLLT 432
Cdd:TIGR00898 428 FQMVYLYTAELYPTVVRNLGVGVC-STMARVGSIISPFLVYLGEKW-----LFLPLVLFGGLALLAGILT 491
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
48-435 |
4.81e-05 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 45.35 E-value: 4.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 48 VFPHIFFPQGDPTAATLQSLATfAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATIGIFAplL 127
Cdd:cd17364 24 ILGRLYYGGKGSLPSGVSGLVN-AAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMG--W 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 128 LALARFGQGLGLGGEWGGAALLATENAPPRKR----ALYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQF--MSWGWRVP 201
Cdd:cd17364 101 LIFFRFLLGIGIGGDYPLSATIMSEYANKKRRgaliAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTYhhADLVWRIV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 202 FIFSAVLVIIGLYVRvslhespvfekvakakkqvkiplgtlltKHVRVTVLGTFIM-LATYT--LFYIMTVYSMTFSTAA 278
Cdd:cd17364 181 LGLGAIPALSVLYFR----------------------------KHLLGTAGTWFLLdIAFYGqnLFQSTIISAIGFSKTM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 279 APVGLGLpRNEVLWmLMMAVIGFGVMVPVAGLLADAFGRRKSMV---IITTLIILFALFAFNPLlgSGNPILVFAFllLG 355
Cdd:cd17364 233 NAYQELF-NIAVGQ-LIIALAGTVPGYWFTVFLIDRIGRKKIQMmgfFGMTIFLLILAGPYDHW--KISTIGFFVL--YG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 356 LSLMGLTFGP--MGALLP-ELFPTEVRYTGASFSyNVASILGASVAPYIAAWLQTNYGLSAVGLYLAAMAGLTLIALLLT 432
Cdd:cd17364 307 LTFFFSNFGPntTTFIVPaEVFPARVRSTCHGIS-AASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLF 385
|
...
gi 15833657 433 HET 435
Cdd:cd17364 386 PEE 388
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
60-430 |
1.80e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.31 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 60 TAATLQSLATFAIAFVARPigsaVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATIGIFAPLL-LALARFgqglg 138
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQP----LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAgIGSAAF----- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 139 lggeWGGAALLATENAPPRkRALYGSFPQLGAPIGFFFANgtfLLLSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVS 218
Cdd:cd17478 102 ----HPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGP---LIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 219 LHESPVFEKVAKAKKQVKIPLGTLLTKHVRVTVLGTFIM-LATYTLFYIMTVYsmtFSTAAAPVGLGLprnevlwMLMMA 297
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSsLTTFLPFYLVQRG---YSLVFAGLLLSL-------FLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 298 VIGfgvmVPVAGLLADAFGRRKSMVIITTL-IILFALFAFNPllgsgnPILVFAFLLLGLSLMGLTFGPMGALLPELFPT 376
Cdd:cd17478 244 AIG----TLIGGPLSDRFGRRRVIIASLLLaAPFLLLFLLTP------GIWSYILLVLAGFLLFASFPVTVVLAQELLPG 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15833657 377 EVRyTGASFSYNVASILGAsVAPYIAAWLQTNYGLSAVGLYLAAMAGLTLIALL 430
Cdd:cd17478 314 NVG-LASGLMMGLSFGLGG-IGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
74-431 |
1.84e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 43.50 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 74 FVARPIGSAVFGHFGD-RVGRKATLVASLLTMGISTVVIGLLPGYATIGIFaplllalaRFGQGLGLGGEWGGAALLATE 152
Cdd:cd17378 43 FVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFL--------RFLTGFGRSGIGTCALVLATE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 153 NAPPRKRalygsfPQLGAPIGFFFANGtFLLLSWLltdEQFMSWGWRVPFIFSAVLVIIglyvrvslhespvfekvakak 232
Cdd:cd17378 115 PVGPKWR------GQVGMSTFFFFVLG-FMSLPGI---AYLNGSSWRVLYFWTSIPALI--------------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 233 kqvkipLGTLLTKHVRVTVLGTFIMLATYTLFYIMtvysmtfstaaaPVGLG-LPRNEVLWMLMMAVIGFGVMVPVAGLL 311
Cdd:cd17378 164 ------YCILVYLFARRLLAVMVIGFGIGMVYYGI------------PLAVGnLKFNIYLSVALNALSELPAFVITAFLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 312 aDAFGRRKSMVIITTLIILFALFAFnPLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFsYNVAS 391
Cdd:cd17378 226 -DRFGRRPSLLGFTLLSGASCLLCF-VLSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGM-LRQAL 302
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 15833657 392 ILGASVAPYIAAWLQTNYGLSaVGLYLAAMAGLTLIALLL 431
Cdd:cd17378 303 VVGGIFAPFIVSLGRKNAALS-FGVFGVAILLLGLFALGL 341
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
85-431 |
1.92e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.33 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 85 GHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATigifapllLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGS 164
Cdd:cd17319 59 GWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 165 FPQLGAPIGFFFAngtFLLLSWLLTdeqfmSWGWRVPFIFSAVL-VIIGLYVRVSLhespvfekvakakkqvkiplgtll 243
Cdd:cd17319 131 LFNSGAPLGAAIG---PPLSGWLLL-----LFGWRWAFIIEGLLgLLLAVLWWFYL------------------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 244 tKHVRVTVLGTFIMLATYTLF------YIMTVYSMTFSTAAapvglglprnevLWMLMMAVIGFGVMVpVAGLLADAF-- 315
Cdd:cd17319 179 -RQVWGLALGYFGINYALYGLltwlptYLKQARGFSLKQVG------------LLAAIPFLAGAIGMI-LGGRLSDRLlr 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 316 GRRKSMVIIttlIILFALFAFNPLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFsYNVASILGA 395
Cdd:cd17319 245 GARRLVIII---GLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL-INSGGNLGG 320
|
330 340 350
....*....|....*....|....*....|....*..
gi 15833657 396 SVAPYIAAWL-QTNYGLSAVGLYLAAMAGLTLIALLL 431
Cdd:cd17319 321 FVAPLLIGYLvDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
27-225 |
2.48e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 43.02 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 27 SLIGTAIEFFDFYIYATAAvivfpHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGI 106
Cdd:cd17357 17 GVVNAPQEVFKEFINDTLV-----DRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 107 STVVIGLlpgyaTIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFanGTFLLLSW 186
Cdd:cd17357 92 SSLLMFL-----SKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILL--GQVFGLPS 164
|
170 180 190
....*....|....*....|....*....|....*....
gi 15833657 187 LLTDEQfmswGWRVPFIFSAVLVIIGLYVRVSLHESPVF 225
Cdd:cd17357 165 VLGTET----LWPYLLFFPGIPALLQLAALPFFPESPKF 199
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
78-186 |
2.74e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 42.66 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 78 PIGSAVFGHFGDRVGRKATLVASLLTMGIStvvigllpgyATIGIFAP--LLLALARFGQGLGLGGEWGGAALLATENAP 155
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIF----------GTCAAFAPtfPVYCVLRFLAGFAVSGISINTLILGTEWTT 118
|
90 100 110
....*....|....*....|....*....|..
gi 15833657 156 PRKRALYGSFPQLGAPIGFFFANGT-FLLLSW 186
Cdd:cd17374 119 PRHRALAITLTSCFFSIGQMLLAGLaYAIRDW 150
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
257-431 |
3.21e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 257 MLATYTLFYIMTVYSMTFSTAAAPVGLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIittLIILFALFAF 336
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI---GLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 337 NPLLGSGNPILVFAFLLLGLSLMGLtFGPMGALLPELFPTEVRYTGASFsYNVASILGASVAPYIAAWLQTNYGLSAVGL 416
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGAL-FPAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170
....*....|....*
gi 15833657 417 YLAAMAGLTLIALLL 431
Cdd:pfam07690 156 ILAILSLLAAVLLLL 170
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
292-433 |
1.28e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 40.95 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 292 WMLMMAVIGFGVMV--PVAGLLADAFGRRKSMVI-------ITTLiilfaLFAFNPLLGSGNPILVFAFLLLGLSLMGLt 362
Cdd:cd17337 246 WLQIWGIIFLVNIFfnLIFGILGDKIGWRRTVRWfggvgcaISTL-----LFYYVPQLFGHNYWAALIAAILFGIGLAG- 319
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15833657 363 FGPMGALLPELFPTEvryTGASFS-YNVASILGASVAPYIAAWLQTNYGLSAVglyLAAMAGLTLIALLLTH 433
Cdd:cd17337 320 FVPLSALMPSLAPEH---KGAAMSiLNLGAGLSNFVGPAIVTLFLGSFGAGGV---VWIFAGLYLLSAVLTL 385
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
74-430 |
2.53e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.87 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 74 FVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGY-----------ATIGIFaPLLLALARfgqglglgge 142
Cdd:cd17504 41 LLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLpvliagralqgIGGAVF-PLAFALVR---------- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 143 wggaallatENAPPRKR----ALYGSFPQLGAPIGFFFAngtflllSWLLTDeqfmsWGWRVPFIFSAVLVIIGLYVrvs 218
Cdd:cd17504 110 ---------EEFPPERVpvaqGILSATFGIGAGIGLPLG-------GWIVQH-----LGWRWIFWTAAPVAVLLAAL--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 219 lhespvfekvakakkQVKIPLGTLLTKHVRVTVLGTFIM-LATYTLFYIMTVYSMTfstaAAPVGLGLPRNEVLWMLMMA 297
Cdd:cd17504 166 ---------------VPLIDLRLLRRRNVLLANITALLAgFGMFMVFQLLPQLLQL----PTPTGFGLGITEAGLLLLPG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 298 VIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAfnpLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLpeLFPTE 377
Cdd:cd17504 227 ALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLL---ALLHSSLWALVVALLLIGIGLGLAFASLPNIV--VESVP 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15833657 378 VRYTGASFSYN-VASILGASVAPYIAAWLQTNYGLSAVGLYLAAMAGLTLIALL 430
Cdd:cd17504 302 PDRTGIATGMNtVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGAYVLAFLI 355
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
81-406 |
2.94e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.91 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 81 SAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYAtigifaplLLALARFGQGLGLGGEWGGAALLATENAPPRKRA 160
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW--------QLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 161 LYGSFPQLGAPIGFF--FANGTFLLLSWLltdeqfmswGWRVPFIFSAVL-VIIGLYVRVSLHESPVFEKVAKAKKQVKI 237
Cdd:cd17328 123 RALGVFYFAIPLGSGlgYVVGGLVAQATG---------GWRWAFRVTGVLgVLLAILLLLFVREPPRGAAEGGVMAKSTA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 238 PLGTLLTKHVR------VTVLGTFIM------LATYTLFYIMTVYSMTFSTAAapvglglprNEVLWMLMMAVIGFGVMV 305
Cdd:cd17328 194 TSFLADLKALAknpsfiLSTLGFTAVsfvtgaLAFWAPTFFLRAFGVGDLSSA---------DVGLIFGAITCIAGVLGV 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 306 PVAGLLADAFGRRKS----MVIITTLIILFALFAFNPLLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYT 381
Cdd:cd17328 265 LLGGILADRLRRKTPradpLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRST 344
|
330 340
....*....|....*....|....*
gi 15833657 382 GASFSYNVASILGASVAPYIAAWLQ 406
Cdd:cd17328 345 ASAIQILLSHLLGDAGSPYLIGLIS 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
290-426 |
3.63e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 3.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 290 VLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLI-ILFALFAFNPLLGSGNPILVFAFLLLGLSLMGLTFGPMGA 368
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRaLLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15833657 369 LLPELFPTEVRYTGASF---SYNVASILGASVAPYIAAWLQTNYGLSAVGLYLAAMAGLTL 426
Cdd:cd06173 116 LLPELVPKEQLVRANALnslATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
283-431 |
7.15e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 38.32 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 283 LGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIIL-FALFAFnpllgSGNPILVFAFLLLGLSLMGL 361
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAgLLLRSL-----APSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15833657 362 TFGPMGALLPELFPTEV-RYTGAsfsYNVASILGASVAPYIAAWLQTNYGLSAVglyLAAMAGLTLIALLL 431
Cdd:COG2807 123 GNVLLPGLIKRWFPDRVgLMTGL---YTAAMGLGAALAAGLTVPLAAALGWRGA---LAVWALLALLALLL 187
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
147-430 |
7.17e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 147 ALLATENAPPRKRALYG---SFPQLGAPIGFFFAngtFLLLSWLltdeqfmSWGWRVPFIFSAVLVIIGLYVRVSLHESP 223
Cdd:cd17370 111 ALLADATPPSGRGKAFGlhrALDTLGAVLGPLLA---ALLLYLL-------GGNYRTIFLLAAIPALLALLILLFVVKEY 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 224 VFEKVAKAKKQVKIPlgTLLTKHVRVTVLGTFIMLATYT--LFYIMTVYSMTFSTAAAPVglglprnevLWMLMMAVigF 301
Cdd:cd17370 181 PRPPKLRKKSKKTSL--KKLPKAFWLYLLAVALFALGNFsfAFLILRAQELGLSAALIPL---------LYALFNLV--Y 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833657 302 GVMVPVAGLLADAFGRRKsMVIITTLIILFALFAFnplLGSGNPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYT 381
Cdd:cd17370 248 ALAAYPAGRLSDRIGRKK-LLILGYLSLALAYLGF---ALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGT 323
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 15833657 382 GASFsYNVASILGASVAPYIAAWLQTNYGLSAVGLYLAAMAGLTLIALL 430
Cdd:cd17370 324 AYGL-FNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| |
