|
Name |
Accession |
Description |
Interval |
E-value |
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
17-410 |
0e+00 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 654.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 17 MSEFIAENRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQ 96
Cdd:PRK10213 1 MSEFIAENRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 97 ATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIA 176
Cdd:PRK10213 81 ATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 177 APLGCFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIR 256
Cdd:PRK10213 161 APLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 257 PVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFA 336
Cdd:PRK10213 241 PVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1447699817 337 LIPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMK 410
Cdd:PRK10213 321 LVPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMK 394
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-404 |
4.11e-70 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 225.51 E-value: 4.11e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 38 VFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLL 117
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 118 VSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAA 197
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 198 AMGVLCIFWIIKSLPSLPGEPSHQKQ---NTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLTLVL 274
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGllsSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 275 LSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSLADQA 354
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1447699817 355 EKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVT 404
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
32-387 |
6.15e-39 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 143.88 E-value: 6.15e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 32 RPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASL-FITQTIQATDRRYVVILFAVL 110
Cdd:PRK03545 5 KVAWLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLpLMLLTSNVERRKLLIGLFVLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 111 LtLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWR 190
Cdd:PRK03545 85 I-ASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 191 NVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGL 270
Cdd:PRK03545 164 TTFLAIGGGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENFA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 271 TLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSL 350
Cdd:PRK03545 244 TLLLLLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLKLA 323
|
330 340 350
....*....|....*....|....*....|....*..
gi 1447699817 351 ADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTS 387
Cdd:PRK03545 324 PDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSS 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
29-354 |
3.89e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 127.40 E-value: 3.89e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 29 AITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFA 108
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 109 VLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIG 188
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 189 WRNVFNAAAAMGVLCIFWIIKSLP-SLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGV 267
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPeSRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 268 DGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWIT 347
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
....*..
gi 1447699817 348 RSLADQA 354
Cdd:COG2814 323 ELAPPEA 329
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
38-381 |
2.32e-24 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 103.63 E-value: 2.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 38 VFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLL 117
Cdd:PRK10091 5 ILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 118 VSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAA 197
Cdd:PRK10091 85 FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 198 AMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLTLVLLSF 277
Cdd:PRK10091 165 VFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 278 GIASFVGTSLSSFILKRSVKLALAG-APFVLALSALVLTLWGSDKIVATGVAIIW--GLtFALIPVGWSTWITRSLADQA 354
Cdd:PRK10091 245 GLGMVLGNLLSGRLSGRYSPLRIAAvTDFIIVLALLMLFFFGGMKTASLIFAFICcaGL-FALSAPLQILLLQNAKGGEL 323
|
330 340
....*....|....*....|....*..
gi 1447699817 355 EKAGSIQVAvIQLANTCGAAIGGYALD 381
Cdd:PRK10091 324 LGAAGGQIA-FNLGSAIGAYCGGMMLT 349
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
41-402 |
3.08e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 100.19 E-value: 3.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 41 VAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSF 120
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 121 ANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLG--CFLGELIGWRNVFNAAAA 198
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGgiLASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 199 MGVLCIFWIIKSLPSLPGEPSHQKQN---------TFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDG 269
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEassksvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 270 LTLVLLSFGIASFVGTSLSSFILKR--SVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWIT 347
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRliGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1447699817 348 RSLADQAEKAGSIQVAVIQLANTCGAAIGGYALD-NIGLTSPLMLSGTLMLLTALL 402
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAIL 376
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
27-403 |
1.09e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 89.54 E-value: 1.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 27 ADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVIL 106
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 107 FAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGEL 186
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 187 IGWRNVFNAAAAMGVLCIFWiikslpslpgepshqkqntfrllqrpGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFG 266
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL--------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 267 VDGLTLVLLSFGIASFVGTSLSSFI---LKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWS 343
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVGSLLGGWLsdrLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 344 TWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLV 403
Cdd:COG2271 295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-407 |
1.87e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.17 E-value: 1.87e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 41 VAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSF 120
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 121 ANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMG 200
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 201 VLCIFWIIKSLPSLPGEPSHQKQNTFR-------LLQRPGVMAGMIAIFMSFAGQFAFFTYIrPVYMT-LAGFGVDGLTL 272
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARlrsglrlLLRDRRLLALFLAIFVLAFAFGALEPFL-PLYAAeLGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 273 VLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWIT-RSLA 351
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAdIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1447699817 352 DQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKV 407
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-411 |
2.46e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 88.78 E-value: 2.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 35 WSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLS 114
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 115 CLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFN 194
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 195 AAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFR----LLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGL 270
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRdqleALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 271 TLVLLSFGIASFVGTSLSSFILKR-SVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWI-TR 348
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRiGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVpDI 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1447699817 349 SLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMKK 411
Cdd:COG2223 324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
42-403 |
5.68e-19 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 87.63 E-value: 5.68e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 42 AFCVACLIIVEFLPVSLLTP----MAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLL 117
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPalpaIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 118 VSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAA 197
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 198 AMGVLCIFWIIKSLP-SLPGEPSHQKQNTF-----RLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLT 271
Cdd:cd17320 161 LLGLLLLLLVLLFLPeTLPEEKRKPLLSSLlraykRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 272 LVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGW--STWITRS 349
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLifPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1447699817 350 LADQAEKAGSIQvAVIQLANTCGAAIGGYALDNIGLTSPLMLsGTLMLLTALLV 403
Cdd:cd17320 321 LEPFPHVAGTAS-ALLGFLQFLIGALAGALVGLLPNGTALPM-GLLILVLGLLA 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
53-350 |
2.16e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.55 E-value: 2.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 53 FLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRA 132
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 133 CLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFWIIKSLP 212
Cdd:pfam07690 94 LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 213 SLPGEPSHQKQ-------NTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIrPVYMTLAGFGVDGLTLVLLSFGIASFVGT 285
Cdd:pfam07690 174 PPESKRPKPAEearlsliVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL-PLYQEVLGLSALLAGLLLGLGGLLGAIGR 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1447699817 286 SLSSFILKR---SVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSL 350
Cdd:pfam07690 253 LLLGRLSDRlgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-407 |
2.71e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.86 E-value: 2.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 53 FLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRA 132
Cdd:cd17489 13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 133 CLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIF--WIIKS 210
Cdd:cd17489 93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLlvFLVKD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 211 LPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIrPVYMtlAGFGVDGLTLVLLSFGIASFVGTSLSSF 290
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFL-PLYA--AERGISNAGLFFTVYAIALLLSRPFSGK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 291 ILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTF-ALIPVGWSTWITRSLADQAEKAGSIQVAVIQLAN 369
Cdd:cd17489 250 LSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFgLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGI 329
|
330 340 350
....*....|....*....|....*....|....*...
gi 1447699817 370 TCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKV 407
Cdd:cd17489 330 GLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
37-405 |
7.30e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 75.30 E-value: 7.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 37 AVFSVAFcvacliiVEFLPVSLLTP----MAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLT 112
Cdd:cd17474 3 AVFFATL-------LAVLGVSIVDPilpaIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 113 LSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGeLIGWRNV 192
Cdd:cd17474 76 IGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 193 F---NAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGM-IAIFMSFAGQFAFFTYIRPVYMTLAGFGVD 268
Cdd:cd17474 155 FfllAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFlVSAFLYFFLYFAFLTYLPFLLELLYGISPI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 269 GLTLVLLSFGIASFVGTSLSSFILKRSV-KLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWIT 347
Cdd:cd17474 235 IIGLLFAGWSVLLALGSLFVGRLLKKRFgARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVT 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 348 RsLADQAEKAGSIQV--AVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTA 405
Cdd:cd17474 315 E-LAPEEERGTASSLynFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
57-412 |
7.52e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.58 E-value: 7.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 57 SLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGL 136
Cdd:COG0738 29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 137 ALGGFWAmSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFL---GELIGWRNVFNAAAAMGVLCIFWIIKS--- 210
Cdd:COG0738 109 GLGLLDV-AANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYLILAVLLLLLALLFLRSklp 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 211 -LPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSS 289
Cdd:COG0738 188 eIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 290 FILKR--SVKLALAGApfVLALSALVLTLWGSDKIVATGVAIIWGLTFALI-PVGWStWITRSLADQAEKAGSIQVAVIQ 366
Cdd:COG0738 268 FLLKRfgPVRLLRLSA--LLAAVGLLLALLAPGPWLALIGLALVGLGLSLMfPTIFS-LALDGLGKRTAAAVSAVLIMGI 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1447699817 367 LANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMKKS 412
Cdd:COG0738 345 VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
62-382 |
7.06e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 69.53 E-value: 7.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 62 MAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGF 141
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 142 wAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFWIikslPSLPgepshq 221
Cdd:cd17504 102 -PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV----PLID------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 222 kqntFRLLQRPGVMAGMIAIFMSFAGQFAFFtYIRPVYM-----TLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKR-S 295
Cdd:cd17504 171 ----LRLLRRRNVLLANITALLAGFGMFMVF-QLLPQLLqlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARvG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 296 VKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSL-ADQAEKAGSIQVAVIQLANTCGAA 374
Cdd:cd17504 246 PRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVpPDRTGIATGMNTVLRTIGSAIGPA 325
|
....*...
gi 1447699817 375 IGGYALDN 382
Cdd:cd17504 326 IAGAILTT 333
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
59-375 |
2.38e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 64.90 E-value: 2.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 59 LTPMAQDLGISEgVAGQSVTVTAFVAMFASLFITQTIQAT-DRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLA 137
Cdd:cd17503 19 LPTIMGDLGASL-DTVQWVITSYLLALAIMIPLSGWLADRfGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 138 LGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFwiikSLPSLPge 217
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALL----LAPLLD-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 218 pshqkqntFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKR-SV 296
Cdd:cd17503 172 --------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKfGP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 297 KLALAGAPFVLALSALVLTLWGSDKIVA--TGVAIIWGLTFALIPVGWSTWITRSLA-DQAEKAGSIQVAVIQLANTCGA 373
Cdd:cd17503 244 RLLLLAGLLLLALGTLLLAFLTPDTSLWliILPLFIRGLGMGLVFMPLNTLALNSLPpEQIGDATALFNTIRQLGGSIGT 323
|
..
gi 1447699817 374 AI 375
Cdd:cd17503 324 AL 325
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
31-317 |
4.67e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 60.21 E-value: 4.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 31 TRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVL 110
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 111 LTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWR 190
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 191 NVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGL 270
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1447699817 271 TLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLW 317
Cdd:COG0477 249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
100-336 |
7.87e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.88 E-value: 7.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 100 RRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPL 179
Cdd:cd17321 60 RKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 180 GCFLGELIGWRNVFNAAAAMGVLCIFWIikslpslpgepshqkqntfrllqrPGVMAGMIAIFMSFAGQFAFFTYIRPVY 259
Cdd:cd17321 140 GGLLLELFGWRWIFLINVPIGLVALLLA------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYL 195
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1447699817 260 MTLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKR-SVKLALAGAPFVLALSALVLTLWGSDkivATGVAIIWGLTFA 336
Cdd:cd17321 196 QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRfGPRLVLVAGLLLTAVGLLLLALLGAD---SSVWLLLPGLVLL 270
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
58-403 |
2.48e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 58.35 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 58 LLTPMAQDLGISEGVAGqsvtvTAFVAMFASLFITQTIQ--ATDR---RYVVILFAVLLTLSCLLVSFANSFSLLLIGRA 132
Cdd:cd17319 25 AAPTIMKDLGLSPTQYG-----LIASAFFLGYALFQVPGgwLLDRfgaRKVLAVSMLLWSLFTALTGFATSLTSLYVLRF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 133 CLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFWIIKSLP 212
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 213 SlpgepshqkqntfrllqrpgvMAGMIAIFMSFAGQFAFFTYIRPVYMTlAGFGVDGLTLVLLSF------GIASFVGTS 286
Cdd:cd17319 180 Q---------------------VWGLALGYFGINYALYGLLTWLPTYLK-QARGFSLKQVGLLAAipflagAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 287 LSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSLADQAEKAGSIQVAVIQ 366
Cdd:cd17319 238 LSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGN 317
|
330 340 350
....*....|....*....|....*....|....*...
gi 1447699817 367 LANTCGAAIGGYALDNIG-LTSPLMLSGTLMLLTALLV 403
Cdd:cd17319 318 LGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLV 355
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
101-401 |
4.56e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 57.61 E-value: 4.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 101 RYVVILFAVLLTLSCLLVSF-ANSFSLLLIGRAclglaLGGFWAMSA---SLTMRLVPPRTVPKALSVIFGAVSIALVIA 176
Cdd:cd17472 61 RKPVILFGLLLFIAGSLLAAyATSIYGLILGRA-----LQGSGAISSvvmALLADLTREENRTKAMALIGASIGIAFAIS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 177 APLGCFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQ---KQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFT 253
Cdd:cd17472 136 MVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISekeKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFY 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 254 YIrPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSSFIL--KRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIW 331
Cdd:cd17472 216 IL-PLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAekKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIF 294
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447699817 332 GLTFALIPVGWSTWITRSLADQAEKAGSIQVAVIQ-LANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTAL 401
Cdd:cd17472 295 FIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQfLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLL 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
25-338 |
5.15e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 57.58 E-value: 5.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 25 RGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVV 104
Cdd:COG2807 7 SARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 105 ILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRtVPKALSVIFGAVSIALVIAAPLGCFLG 184
Cdd:COG2807 87 LLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 185 ELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNT--FRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTL 262
Cdd:COG2807 166 AALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAslRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA 245
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1447699817 263 ---AGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALI 338
Cdd:COG2807 246 glsAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLA 324
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
63-341 |
6.49e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.23 E-value: 6.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 63 AQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFW 142
Cdd:cd17316 28 EFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 143 AMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGEL----IGWRNVFNAAAAMGVLCIFWiikslpslpgep 218
Cdd:cd17316 108 PGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLlsgdWGWRILFLIGALPALLALLL------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 219 shqkqntfrllqRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKR-SVK 297
Cdd:cd17316 176 ------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRiGRK 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1447699817 298 LALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVG 341
Cdd:cd17316 244 KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWG 287
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
77-338 |
7.48e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.20 E-value: 7.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 77 VTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFwaMSASLTM------ 150
Cdd:cd17473 41 LTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGI--MTLATALigdyfe 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 151 ---RLvpprtvpKALSVIFGAVSIALVIAAPLGCFLGElIGWRNVFnAAAAMGVLCIFWIIKSLP---SLPGEPSHQKQN 224
Cdd:cd17473 119 geeRA-------KMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPF-LVYLLALPVLILVLLFLPepaRKSKSAASPGAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 225 TFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIrPVYMTLAGFGVDGLT-LVLLSFGIASFVGTSLSSFILKRSVKLALAGA 303
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQL-PFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKRRLGKRRLLAI 268
|
250 260 270
....*....|....*....|....*....|....*
gi 1447699817 304 PFVLALSALVLTLWGSDKIVATGVAIIWGLTFALI 338
Cdd:cd17473 269 GFALMALGFLLLALASGLWVVLLGAILAGLGFGLL 303
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
104-403 |
8.70e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.85 E-value: 8.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 104 VILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFL 183
Cdd:cd06173 72 LLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 184 GELIGWRNVFNAAA---AMGVLCIFWIIKSLPSLPGEPSHQKQNTFR-----LLQRPGVMAGMIAIFMSFAGQFAFFTYI 255
Cdd:cd06173 152 VALLGPGGAFAINAlsfLLSALLLLFIRRPPPAAPGESSSLLLRDLReglryLRRSPLLRLLLLALALFALLGGALTVLL 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 256 RPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTF 335
Cdd:cd06173 232 PLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAG 311
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1447699817 336 ALIPVGWSTWITRSLADQ-AEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLV 403
Cdd:cd06173 312 GLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
63-261 |
4.26e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 54.86 E-value: 4.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 63 AQDLGISEGVAGQSVTVTAFVAMFASLFI-TQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIgracLGLALGGF 141
Cdd:cd17471 24 TEELGASPLQIGIFMTLSALSGIVVSQWLgRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYWVLLL----VGVVLLSL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 142 WAMSASLTMRLV-------PPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSL 214
Cdd:cd17471 100 GAAAFPQLFALAreyadrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSV 179
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1447699817 215 PGEPSHQKQNT--FRLLQRPGVMAGMIAIFMSFAGQFAFFTYIrPVYMT 261
Cdd:cd17471 180 KPPAQKATPASslVKAPVNRRLLLLFAAFTLLFAANSMYIIAM-PLYVT 227
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
81-212 |
4.66e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 51.88 E-value: 4.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 81 AFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPK 160
Cdd:TIGR00880 8 ALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGV 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1447699817 161 ALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFWIIKSLP 212
Cdd:TIGR00880 88 ALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
52-315 |
5.12e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.55 E-value: 5.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 52 EFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGR 131
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 132 ACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFgavsialvIAAPLGCFLG---------ELIGWRNVFNAAAAMGVL 202
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY--------FAIPLGSGLGyvvgglvaqATGGWRWAFRVTGVLGVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 203 C---IFWIIKSLPSLPGEPSHQKQNTFR--------LLQRPGVMAGMIA-IFMSFA-GQFAFFTyirPVYMTLAgFGVDG 269
Cdd:cd17328 167 LailLLLFVREPPRGAAEGGVMAKSTATsfladlkaLAKNPSFILSTLGfTAVSFVtGALAFWA---PTFFLRA-FGVGD 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1447699817 270 LTLVLLSF------GIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLT 315
Cdd:cd17328 243 LSSADVGLifgaitCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAA 294
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
58-294 |
7.46e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 53.85 E-value: 7.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 58 LLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLA 137
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 138 LGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSI----ALVIAAPLGCFLGELIGWRNVFnAAAAMGVLCIFWIIKSLPS 213
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLF-LLGALPALLVLFIRRFVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 214 LPGEPSHQKQNT-------FRLLQRPGVMAGMIAIFMSFAGQ---FAFFTYIRPVYMTLA-GFGVDGLTLVLLSFGIASF 282
Cdd:cd17371 180 PPQWQAARAARRhfadrpsLRELFSPPLLRTTLLASLLATGAlggYYGITTWLPSYLTGErGLSFEGSAGYLVVTILGGF 259
|
250
....*....|..
gi 1447699817 283 VGTSLSSFILKR 294
Cdd:cd17371 260 LGYLAGGFLADR 271
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
43-403 |
1.22e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 53.38 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 43 FCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLT-LSCLLVSFA 121
Cdd:cd17490 3 IIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTvLASLIMILF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 122 NSFSLLLIGRACLGLAlGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGV 201
Cdd:cd17490 83 PSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 202 ----LCIFwiIKSLPSLPGEPSHQKQNTFRLLQRPGVM-AGMIAIFMSFAgQFAFFTYIRPVYMTLAGFGVDGLTLVLLS 276
Cdd:cd17490 162 lgfiLSLF--IKEERREKKPVLTELKELLSVLKDKKLLfFSLLAILQQMI-TFSTTFGFTPLIAKQLGASSFQLGLLSII 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 277 FGIASFVGTSLSSFILKRS---VKLALAGapFVLALSALVLTLWGSDKIVATGVAIIWGLTFALI-PVGWSTWITRSLAD 352
Cdd:cd17490 239 YLLPNALASLLSGTLFYKKlgeRNTIIIG--FLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILfPLLMSLSIEGVPAE 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1447699817 353 QAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLV 403
Cdd:cd17490 317 QRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILS 367
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
99-338 |
1.55e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 52.95 E-value: 1.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 99 DRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAP 178
Cdd:cd17502 58 GRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 179 LGCFLGELIGWRNVFNAAAAMGVLCIFWIikslpslpgepshqkqntfrllqrPGVMAGMIAIFMSFAGQFAFFTYIrPV 258
Cdd:cd17502 138 IGGAFTDHLSWRWCFYINLPIGGLALALL------------------------RTILLSSIFGFLFGGALFGLIYYL-PL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 259 YM-TLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRS--VKLALAGAPFVLALSALVLTL--WGSDKIVATGVAIIWGL 333
Cdd:cd17502 193 YFqLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTgrYKPLIVIGTILMSVGAGLLTTltLDTSKWLLIGYLILLGL 272
|
....*
gi 1447699817 334 TFALI 338
Cdd:cd17502 273 GLGIG 277
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
62-387 |
1.91e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.98 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 62 MAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRY-----VVILFAVLLTLSCLLVSFANSFSllliGRACLGL 136
Cdd:COG2211 37 YTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLS----PTGKLIY 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 137 ALGGFWAMSASLTMRLVP-----------PRTVPKALSVIFGAVSIALVIAAPLGCFLGELI------GWRNVFNAAAAM 199
Cdd:COG2211 113 ALVTYLLLGLAYTLVNIPysalgaeltpdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 200 GVLCI---FWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLTLVLLS 276
Cdd:COG2211 193 GLLAFlltFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLAL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 277 FGIASFVGTSLSSFILKR--SVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSLADQA 354
Cdd:COG2211 273 YFLAALLGAPLWPRLAKRfgKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDE 352
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1447699817 355 EKAG--------SIQVAVIQLANTCGAAIGGYALDNIGLTS 387
Cdd:COG2211 353 WKTGrrreglyfGIFTFAIKLGQALAGALAGLLLALFGYVA 393
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
58-403 |
3.33e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 51.89 E-value: 3.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 58 LLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANS-FSLLLIGRACLGL 136
Cdd:cd17355 25 FIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSlWQLYLLWGLLGGG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 137 ALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCI----FWIIKSLP 212
Cdd:cd17355 105 GAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLvpvlLLLRRRPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 213 SLPGEPSHQKQN-----TFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLTLVLLSFGIASFVGTSL 287
Cdd:cd17355 185 DLALRAYDDASPaspgsTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 288 SSFILKR-SVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLT-FALIPVGWSTWITRSLADQAEKAGSIQVAVI 365
Cdd:cd17355 265 SGWLGDRySPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGwGATVPLTAALAARYFGARSYGTLFGLVFAPH 344
|
330 340 350
....*....|....*....|....*....|....*....
gi 1447699817 366 QLANTCGAAIGGYALDNIG-LTSPLMLSGTLMLLTALLV 403
Cdd:cd17355 345 QLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLV 383
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
62-405 |
3.34e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.86 E-value: 3.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 62 MAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGF 141
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 142 WAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLC--IFWIIKSLPSLPGEPS 219
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAavLFWLFYREPPAASAAT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 220 HQKQNTFR----LLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDG----LTLVLLSfGIASFVGTSLSS-- 289
Cdd:cd17475 182 ESASTLLRslkeVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAagalLAVAQLG-GALGRIGLGRVSdr 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 290 -FILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSL-ADQAEKAGSIQVAVIQL 367
Cdd:cd17475 261 vFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAgPEQAGTALGLANTINFI 340
|
330 340 350
....*....|....*....|....*....|....*...
gi 1447699817 368 ANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTA 405
Cdd:cd17475 341 GIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
62-212 |
4.14e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 51.59 E-value: 4.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 62 MAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGF 141
Cdd:TIGR00895 43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447699817 142 WAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFWIIKSLP 212
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
61-204 |
9.23e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 9.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 61 PMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGG 140
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGA 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1447699817 141 FWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCI 204
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILL 167
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
67-341 |
9.57e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.25 E-value: 9.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 67 GISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSA 146
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 147 SLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWrnVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTF 226
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--PFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 227 RLLQRPGVmaGMIAIFMSFAGQFAFFTYIrPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVK-LALAGAPF 305
Cdd:cd17477 185 RLLRIAPL--ALLGAFVAGFLEGAFYSLL-PLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRrRVLLGCAL 261
|
250 260 270
....*....|....*....|....*....|....*..
gi 1447699817 306 VLALSALVLTLWGSDKIVATGVAIIWG-LTFALIPVG 341
Cdd:cd17477 262 LGALAALLLPLVPGLPLALLVLLFLWGgAAGPLYTLA 298
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
62-403 |
1.37e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 62 MAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGF 141
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 142 WAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELiGWRNVFNAAAAMGVLCIFWIIKSLP-----SLPG 216
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPetrpkRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 217 EPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSV 296
Cdd:cd17329 185 EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 297 KLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRsLADQAEKAGSIQVA--VIQLANTCGAA 374
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA-LAPPDKRGSYMGFYalAWGLGRAIGPL 343
|
330 340
....*....|....*....|....*....
gi 1447699817 375 IGGYALDNIGLTSPLMLSGTLMLLTALLV 403
Cdd:cd17329 344 VGGLLLDLLGPGLPWLILAALGLIAAALL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
38-208 |
1.62e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.90 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 38 VFSVAFCVACLIIVEFLPVSLLTPMAQDLGISegVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLL 117
Cdd:cd17489 196 VLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 118 VSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAA 197
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
170
....*....|.
gi 1447699817 198 AMGVLCIFWII 208
Cdd:cd17489 354 VVVLLALVLYI 364
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
63-294 |
2.66e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 49.14 E-value: 2.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 63 AQDLGISEGVAgqSVTVTAFVAMFA--SLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRAclglaLGG 140
Cdd:PRK11102 18 AADFGVSAGSV--QMTLSAYILGFAigQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF-----LHG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 141 FWAMSASLT----MR-LVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLC---IFWIIK-SL 211
Cdd:PRK11102 91 LAAAAASVVinalMRdMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAaalVFFFIPeTL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 212 PSLPGEPSHQK---QNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVD------GLTLVLLsfgiasF 282
Cdd:PRK11102 171 PKERRQPFHLRttiRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQnfgyyfALNIVFL------F 244
|
250
....*....|..
gi 1447699817 283 VGTSLSSFILKR 294
Cdd:PRK11102 245 VMTIINSRFVRR 256
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
37-210 |
1.19e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 37 AVFSVAFCVACLIIVEFLPVSLLTPMAQD-LGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSC 115
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 116 LLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNA 195
Cdd:cd06173 289 LVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
|
170
....*....|....*
gi 1447699817 196 AAAMGVLCIFWIIKS 210
Cdd:cd06173 369 AGALLLLAALLLLLL 383
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
17-212 |
1.23e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 47.38 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 17 MSEFIAENRGADAITRPNWSAvFSVAFCVACLIIVEFLPVSL-LTPMAQDLGISEgVAGQSVTVTAFVAM-FASLFITQT 94
Cdd:PRK03893 1 MSTTTQNIPWYRHLNRAQWKA-FSAAWLGYLLDGFDFVLITLvLTEVQGEFGLTT-VQAASLISAAFISRwFGGLLLGAM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 95 IQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALV 174
Cdd:PRK03893 79 GDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAV 158
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1447699817 175 IAAPLGCFLGELIGWRNVFnaaaAMGVLCIF---WIIKSLP 212
Cdd:PRK03893 159 VAAQVYSLVVPVWGWRALF----FIGILPIIfalWLRKNLP 195
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
74-312 |
1.73e-05 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 46.58 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 74 GQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALgGFWAMSASLTM-RL 152
Cdd:cd17362 42 GLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGI-GLAMHAAPVYIaET 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 153 VPPRTVPKALSVIFGAVSIALVIAAPLG-CFLGELIGWRNVFNAAAAMGVLCIFwiikSLPSLPGEPSHQKQNtfrllQR 231
Cdd:cd17362 121 SPSHIRGLLVSLKELFIVLGILLGYVSGyAFADVVGGWRYMYGLAAPPALLLGI----GMWFLPPSPRWQGNY-----RK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 232 PGVMAGMIAIFMSFAGQFAFFTYIRPVYMTlAGF-GVDGLTLVLLSFGIASFVGTSLSSFILKR--SVKLALAG-APFVL 307
Cdd:cd17362 192 PLIIGLGLVLFQQITGQPSVLYYAATIFKS-AGFsAASDATLVSVGLGVFKLLMTIVAVLLVDKlgRRPLLLGGvSGMVV 270
|
....*
gi 1447699817 308 ALSAL 312
Cdd:cd17362 271 SLFLL 275
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
41-208 |
2.68e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 41 VAFCVACLIIVEFLPVSLLTPMAQD-LGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRY--VVILFAVLLTLSCLL 117
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 118 VSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAA 197
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLA 344
|
170
....*....|.
gi 1447699817 198 AMGVLCIFWII 208
Cdd:COG2271 345 ALALLAALLAL 355
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
59-231 |
3.91e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 45.40 E-value: 3.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 59 LTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLAL 138
Cdd:PRK10473 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 139 GGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGV----LCIFWIIKSLPSL 214
Cdd:PRK10473 106 GCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGIlvllLSLFILKETRPAR 185
|
170
....*....|....*...
gi 1447699817 215 PGEP-SHQKQNTFRLLQR 231
Cdd:PRK10473 186 APAAsSKPRENSESLLNR 203
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
33-222 |
6.15e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 44.90 E-value: 6.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 33 PNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGvAGQSVTVTAFVAMFASLFITQTIqaTDR--RYVVILFAVL 110
Cdd:PRK11652 5 RNVNLLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREG-AVQAVMAAYLLTYGLSQLFYGPL--SDRvgRRPVILVGMS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 111 L-TLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGW 189
Cdd:PRK11652 82 IfILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGW 161
|
170 180 190
....*....|....*....|....*....|....
gi 1447699817 190 RNVFNAAAAMGVLCIFWIIKSLP-SLPGEPSHQK 222
Cdd:PRK11652 162 RACYLFLLLLGAGVTFSMARWMPeTRPADARRTR 195
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
103-212 |
6.27e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 44.85 E-value: 6.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 103 VVILFAVLL-TLSCLLVSFA--NSFSLLLIGRACLGLALG-GFWAMsASLTMRLVPPRTVPKALSVIFGAVSIALVIAAP 178
Cdd:cd17380 65 KVLLLAVALwSLATLLTPLLaySSLPLLILSRILLGLGEGvHFPSM-TSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGL 143
|
90 100 110
....*....|....*....|....*....|....*
gi 1447699817 179 LGCFLGELIGWRNVFNAAAAMGVL-CIFWIIKSLP 212
Cdd:cd17380 144 IGPLLLEYYGWPSVFYFFGLLGLLwALVWLIYLPP 178
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
58-339 |
7.34e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 44.60 E-value: 7.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 58 LLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLA 137
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 138 LGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCF-LGELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPG 216
Cdd:cd06180 101 SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAgLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 217 EPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIrPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKR-S 295
Cdd:cd06180 181 APTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFL-PLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRwG 259
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1447699817 296 VKLALAGAPFVLALSALVLTLWGSDKIVATGvAIIWGLTFALIP 339
Cdd:cd06180 260 TRRALAANLLVQAVGVLLPLLSPGPAGLVLS-AVLFGGTFMAIT 302
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
42-205 |
1.40e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 42 AFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLF--ITQTIQATDRRYVVILFAVLLTLSCLLVS 119
Cdd:cd17352 189 ALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILlgLLADKPRIGRLYLYIFTLLILGLSLLAFP 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 120 FANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGcflGELIGWRNVFNAAA-A 198
Cdd:cd17352 269 LATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIA---GLLRDYTGDYDAAFyF 345
|
....*..
gi 1447699817 199 MGVLCIF 205
Cdd:cd17352 346 CGACLLL 352
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
62-297 |
1.53e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 43.72 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 62 MAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGF 141
Cdd:cd17323 25 IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 142 WAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSlpgepshq 221
Cdd:cd17323 105 LAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPI-------- 176
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447699817 222 kqntfrllqrpgVMAGMIAIFMSFAGQFAFFTYIRPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVK 297
Cdd:cd17323 177 ------------VLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYR 240
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
105-330 |
1.86e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 43.38 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 105 ILFAVLLTLscLLVSFAN-SFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFL 183
Cdd:cd17318 93 ILITALLTL--LTPLAARgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFL 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 184 GELIGWRNVFNAAAAMGVL-CIFWIIKSLPslpgepshqkqntfrllqrpgVMAGMIAIFMSFAGQFAFFTYIrPVYM-T 261
Cdd:cd17318 171 CESLGWPSIFYIFGGLGLLwCLLWFFLVLP---------------------VWAIVVAHFGHNWGFYTLLTEL-PTYMsD 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 262 LAGFGVD--GLTLVL--LSFGIASFVGTSLSSFILKRSV-------KLALAGAPFVLALSALVLTLWGSDKIVATGVAII 330
Cdd:cd17318 229 VLHFNIKsnGFLSSLpyLAMWICSIVGGYLADWLRSRGIlstttvrKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTL 308
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
99-203 |
2.17e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.38 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 99 DRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFwAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAP 178
Cdd:cd06179 60 GRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPL 138
|
90 100
....*....|....*....|....*..
gi 1447699817 179 LGCFLGE--LIGWRNVFNAAAAMGVLC 203
Cdd:cd06179 139 IAGALVEanAAGWRWIFYINAIFNALA 165
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
59-294 |
2.17e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.94 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 59 LTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLAL 138
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 139 GGFWAMSASLTMRLVPPRTVPKALSV--------IFGAVSIALVIAAPLGCFLGELIGWRNVFnAAAAMGVLCIFWIIKS 210
Cdd:cd17359 104 GGASALVPMYIAEVAPAEIRGRLVSLnqlmivfgQLLAYIVNYLIANAGGADWLGAEGWRWML-GLEAIPAILFLLGMLF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 211 LPSLPgepshqkqntfRLL---QRPGVMAG-MIAIFMSFAGQFAFFTYIrPVYMTLAGFGVDGLTLVLLSFGIASFVGTS 286
Cdd:cd17359 183 IPESP-----------RWLvskGKPILIIGiGLAIFQQFVGINVIFYYG-PEIFQNAGFSENAALLQTIGIGVVNVIFTI 250
|
....*...
gi 1447699817 287 LSSFILKR 294
Cdd:cd17359 251 IAILLVDK 258
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
100-193 |
2.76e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.03 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 100 RRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPL 179
Cdd:PRK11551 79 RKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVI 158
|
90
....*....|....
gi 1447699817 180 GCFLGELIGWRNVF 193
Cdd:PRK11551 159 GVLAAGDAAWRHIF 172
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
53-403 |
2.94e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 2.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 53 FLPVsLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRA 132
Cdd:cd17478 14 FLPA-LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 133 CLGLALGGFWAMSASLTmRLVPPRTVPKALSV--IFGAVSIAL--VIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFWII 208
Cdd:cd17478 93 LAGIGSAAFHPEGARLA-SQAAGGRRGLAMSIfsVGGNLGFALgpLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 209 KSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIrPVYMTLAGFGVDGLTLVLLSFGIASFVGTSLS 288
Cdd:cd17478 172 LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFL-PFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 289 SFI-----LKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIiwGLTFALIPVgwstWITRSLADQAEKAGSIQVA 363
Cdd:cd17478 251 GPLsdrfgRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLL--FASFPVTVV----LAQELLPGNVGLASGLMMG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1447699817 364 VIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLV 403
Cdd:cd17478 325 LSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
44-402 |
7.07e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 7.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 44 CVACLIIVEFLPVSLLTPMAQ---DLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSF 120
Cdd:cd17330 4 VVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 121 ANSFSLLLIGRACLGLALGGFwAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMG 200
Cdd:cd17330 84 SRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 201 VLCIFWIIKSLPSLpgepshqkqntFRLLqrpGVMAGMIAIFMSFAGQFAFFTYIRP---VYMTLAGFGVDGLTLVLLSF 277
Cdd:cd17330 163 LLNLVLVLFFLPPL-----------RRLL---LVYFLIALAFAGLESVFSLFLKDRFgfsPSQIGLLLALVGIAGILAQL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 278 GIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIpvgwstwITRSLADQAEKA 357
Cdd:cd17330 229 LLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALL-------SKSVPSKEQGKA 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1447699817 358 GSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALL 402
Cdd:cd17330 302 QGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
34-208 |
7.49e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 7.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 34 NWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTL 113
Cdd:cd17370 197 KLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLAL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 114 SCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVF 193
Cdd:cd17370 277 AYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAF 356
|
170
....*....|....*
gi 1447699817 194 NAAAAMGVLCIFWII 208
Cdd:cd17370 357 LFSAVLALIALLLLL 371
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
99-329 |
1.07e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 41.06 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 99 DRRYVVILFAVLLTLSCLLVSFANSFSLLLigrACLGLALGGFWAMSA------SLTMRLVPPRTVPKALSVIFGAVSIA 172
Cdd:cd17485 64 RRRSWLLPTQLGLALLLLALAFLPPTTNLL---AFLGLLFLLNLFSATqdiatdGLAVELLTPEERGLGNAAQVVGYKLG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 173 LVIAAPLGCFLGELIGWRNVFNAAAAMGVLCI--FWIIKSLPSLPGEPSHQKQNTFR-----LLQRPGVMAGMIAIFMSF 245
Cdd:cd17485 141 SLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLlpVLFLRELELPQQPPASERGAALKaslraFLRRPGTRWLLLFLLLYK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 246 AGQFAFFTYIRPvYMTLAGFGVDGLTLVLLSFG-IASFVGTSLSSFILKR---SVKLALAGAPFVLALSALVLTLWGSDK 321
Cdd:cd17485 221 LGEQGALAMLPP-FLVDRGFSLSQIGLLSGVGGsLVSIAGSLLGGYLLKRrgrRRLLLLGGLLRLLLLGLYTLLALGGSG 299
|
....*...
gi 1447699817 322 IVATGVAI 329
Cdd:cd17485 300 LNWVLLLA 307
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
56-205 |
1.28e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 56 VSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLG 135
Cdd:COG2807 235 VAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLG 314
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 136 LALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLgcFLGELIGWRNVFNAAAAMGVLCIF 205
Cdd:COG2807 315 LGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPL--LVGALHDATGSWTAALLLLAALAV 382
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
63-208 |
1.39e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.52 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 63 AQDLGISEGVAGQSVTVTAFVAMFASL---FITQTIQAtdrRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALG 139
Cdd:COG2270 266 AGVLGFSTTELIVFGLLVQIVAALGALlfgRLDDRIGP---KRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMG 342
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 140 GFWAMSASLTMRLVPprtvPKALSVIFGAVSIALVIAAPLGCFLGELIGWrnVFNAA-AAMGVLCIFWII 208
Cdd:COG2270 343 GIQALSRSLLARLIP----PGREAEFFGLYALSGKAASFLGPLLFGLVTQ--LTGSQrLGILSLIVFFVI 406
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
72-211 |
1.86e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 72 VAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMR 151
Cdd:cd17391 241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 152 LVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMGVLCIFWIIKSL 211
Cdd:cd17391 321 ITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
43-193 |
4.02e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.16 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 43 FCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFA- 121
Cdd:cd17341 6 LSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAv 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1447699817 122 NSFSLLLIGRACLGLALGGFwAMSASLTMRLVPPRTVPKALSVIFGA-------VSIALVIAAPLGCFLGELIGWRNVF 193
Cdd:cd17341 86 SSYWGLLVLGFLLGFAGANF-ASGQPWASFWFPKEKIGGAAGGIAGAgnmgvavSQLLAPLIAGAIVFDGGFVGWRNAF 163
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
53-179 |
4.46e-03 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 38.95 E-value: 4.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 53 FLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASL---FITQTIQATDRRYVVILFAVLLTLSC-LLVSFANSFSLLL 128
Cdd:TIGR00892 258 FAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPscgLIAGLKWIRPHVQYLFSFALLFNGLThLLCALAGDYTGLV 337
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1447699817 129 IGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPL 179
Cdd:TIGR00892 338 IYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPL 388
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
36-177 |
4.64e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 36 SAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLF---ITQTIQATDRRYVVILFAVLLT 112
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLlgrLSDRLGRRRRLLLALLLLILAA 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1447699817 113 LSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAA 177
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
35-205 |
6.22e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.36 E-value: 6.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 35 WSAVFSVAFCVACLIIVeflpVSLLTPMAQDL-GISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTL 113
Cdd:cd17353 216 WLLWLMFFLNATAGLML----IGQAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGV 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 114 SCLLVSFANS-FSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNV 192
Cdd:cd17353 292 AMFLLPFIGSvAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAA 371
|
170
....*....|...
gi 1447699817 193 FNAAAAMGVLCIF 205
Cdd:cd17353 372 FIIAAALSLVALA 384
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
44-202 |
8.25e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 37.92 E-value: 8.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 44 CVACLI--IVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFA 121
Cdd:cd17477 194 LLGAFVagFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLV 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699817 122 NSFSLLLIGRACL-GLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGCFLGELIGWRNVFNAAAAMG 200
Cdd:cd17477 274 PGLPLALLVLLFLwGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVA 353
|
..
gi 1447699817 201 VL 202
Cdd:cd17477 354 LL 355
|
|
| |
