|
Name |
Accession |
Description |
Interval |
E-value |
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
1-348 |
0e+00 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 724.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 1 MATGTQPDAGQILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNE 80
Cdd:PRK11073 1 MATGTLPDAGQILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMRESLQAGQGFTDNE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 81 VTLVIDGRSHILSVTAQRMPDGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALP 160
Cdd:PRK11073 81 VTLVIDGRSHILSLTAQRLPEGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 161 DPSLLEYTKVIIEQADRLRNLVDRLLGPQLPGTRVTESIHKVAERVVTLVSMELPDNVRLIRDYDPSLPELAHDPDQIEQ 240
Cdd:PRK11073 161 DPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIHKVAERVVQLVSLELPDNVRLIRDYDPSLPELAHDPDQIEQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 241 VLLNIVRNALQALGPEGGEIILRTRTAFQLTLHGERYRLAARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIAR 320
Cdd:PRK11073 241 VLLNIVRNALQALGPEGGTITLRTRTAFQLTLHGERYRLAARIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIAR 320
|
330 340
....*....|....*....|....*...
gi 15834045 321 NLIDQHSGKIEFTSWPGHTEFSVYLPIR 348
Cdd:PRK11073 321 NLIDQHSGKIEFTSWPGHTEFSVYLPIR 348
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
5-349 |
2.89e-145 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 414.63 E-value: 2.89e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 5 TQPDAGQILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLV 84
Cdd:COG3852 5 SEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRELLERALAEGQPVTEREVTLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 85 -IDGRSHILSVTAQRMPD----GMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKAL 159
Cdd:COG3852 85 rKDGEERPVDVSVSPLRDaegeGGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLEREL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 160 PDPSLLEYTKVIIEQADRLRNLVDRLLGP--QLPGTRVTESIHKVAERVVTLVSMELPDNVRLIRDYDPSLPELAHDPDQ 237
Cdd:COG3852 165 PDDELREYTQLIIEEADRLNNLVDRLLSFsrPRPPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSLPEVLGDPDQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQALgPEGGEIILRTRTAFQLTLHGERYRLAARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLS 317
Cdd:COG3852 245 LIQVLLNLVRNAAEAM-PEGGTITIRTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLA 323
|
330 340 350
....*....|....*....|....*....|...
gi 15834045 318 IARNLIDQHSGKIEFTSWPG-HTEFSVYLPIRK 349
Cdd:COG3852 324 IVQKIVEQHGGTIEVESEPGkGTTFRIYLPLEQ 356
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
11-347 |
1.23e-71 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 228.69 E-value: 1.23e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 11 QILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLnIELMQESLEAGQgftDNEVTLVIDGRSH 90
Cdd:COG5000 94 TILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDL-AELLREALERGW---QEEIELTRDGRRT 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 91 ILSVTAQRMPDGMILLemapMDNQRRLSQeqlqhAQQVAA-RDLVRGLAHEIKNPLGGLRGAAQLLSKALPD------PS 163
Cdd:COG5000 170 LLVRASPLRDDGYVIV----FDDITELLR-----AERLAAwGELARRIAHEIKNPLTPIQLSAERLRRKLADkleedrED 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 164 LLEYTKVIIEQADRLRNLVDRLL----GPQLpgTRVTESIHKVAERVVTLVSMELPD-NVRLIRDYDPSLPELAHDPDQI 238
Cdd:COG5000 241 LERALDTIIRQVDRLKRIVDEFLdfarLPEP--QLEPVDLNELLREVLALYEPALKEkDIRLELDLDPDLPEVLADRDQL 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 239 EQVLLNIVRNALQALgPEGGEIILRTRTAFQltlhgeryrlAARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSI 318
Cdd:COG5000 319 EQVLINLLKNAIEAI-EEGGEIEVSTRREDG----------RVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAI 387
|
330 340 350
....*....|....*....|....*....|
gi 15834045 319 ARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
Cdd:COG5000 388 VKKIVEEHGGTIELESRPGGgTTFTIRLPL 417
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
6.88e-65 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 200.70 E-value: 6.88e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQALGPEGGEIILRTRTAFQLTLHGERYRLAARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLS 317
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGGEIILRTRTQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100
....*....|....*....|....*....
gi 15834045 318 IARNLIDQHSGKIEFTSWPGHTEFSVYLP 346
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
114-347 |
2.15e-57 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 190.01 E-value: 2.15e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 114 QRRLSQEQLQHAQQVAA-RDLVRGLAHEIKNPLGGLRGAAQLLSKAL----PDPSLLEYTKVIIEQADRLRNLVDRLL-- 186
Cdd:COG4191 125 ELRELQEQLVQSEKLAAlGELAAGIAHEINNPLAAILGNAELLRRRLedepDPEELREALERILEGAERAAEIVRSLRaf 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 187 GPQLPGTRVTESIHKVAERVVTLVSMELPD-NVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQAL-GPEGGEIILRT 264
Cdd:COG4191 205 SRRDEEEREPVDLNELIDEALELLRPRLKArGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMeEGEGGRITIST 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 265 RTAfqltlhGERyrlaARIDVEDNGPGIPPHLQDTLFYPMVS--GREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEF 341
Cdd:COG4191 285 RRE------GDY----VVISVRDNGPGIPPEVLERIFEPFFTtkPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGgTTF 354
|
....*.
gi 15834045 342 SVYLPI 347
Cdd:COG4191 355 TITLPL 360
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
12-349 |
1.10e-56 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 194.03 E-value: 1.10e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 12 ILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLVIDGRSHI 91
Cdd:PRK11360 267 ILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPNTPFASPLLDTLEHGTEHVDLEISFPGRDRTIE 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 92 LSVTAQRMPDG---MI--LLEMAPMDNQRRLsQEQLQHAQQVAAR-DLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLL 165
Cdd:PRK11360 347 LSVSTSLLHNThgeMIgaLVIFSDLTERKRL-QRRVARQERLAALgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQ 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 166 EYTKVIIEQADRLRNLVDRLLGPQLPGTRVTE--SIHKVAERVVTLV-SMELPDNVRLIRDYDPSLPELAHDPDQIEQVL 242
Cdd:PRK11360 426 EYLSVVLREVDRLNKVIDQLLEFSRPRESQWQpvSLNALVEEVLQLFqTAGVQARVDFETELDNELPPIWADPELLKQVL 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 243 LNIVRNALQALgPEGGEIILRTRTAFQLTLHgeryrlaarIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNL 322
Cdd:PRK11360 506 LNILINAVQAI-SARGKIRIRTWQYSDGQVA---------VSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRI 575
|
330 340
....*....|....*....|....*...
gi 15834045 323 IDQHSGKIEFTSWPGH-TEFSVYLPIRK 349
Cdd:PRK11360 576 INAHGGDIEVESEPGVgTTFTLYLPINP 603
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
11-348 |
2.53e-51 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 174.20 E-value: 2.53e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 11 QILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYfslnieLMQESLEAGQGFTDNEVTLVIDGRSH 90
Cdd:COG5807 31 QLFDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKTFVEEKCI------LKDEQLYNKEAFDRIEISYLTKNGEF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 91 ILSVTAQRMPDGMILLEMAPMDN--QRRLSQEQLQHAQQVA-ARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEY 167
Cdd:COG5807 105 DEIIYPIYYKDGVILGLITVYRDitKRKEAEDKLLRSEKLSvAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSEREEY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 168 TKVIIEQADRLRNLVDRLLGPQLPG--TRVTESIHKVAERVVTLVSMELP-DNVRLIRDYDPSLPELAHDPDQIEQVLLN 244
Cdd:COG5807 185 FNIIISEIDRINTIITELLVLSKPKkfNFKKLNLNDVLEDVIALLSTEAIlKNISIKYDLADDEPVINGDKNQLKQVFIN 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 245 IVRNALQALgPEGGEIILRTrtafqltlhgerYRLA--ARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNL 322
Cdd:COG5807 265 LIKNAIEAM-ETGGNITIKT------------YVEGdfVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKI 331
|
330 340
....*....|....*....|....*..
gi 15834045 323 IDQHSGKIEFTSWPGH-TEFSVYLPIR 348
Cdd:COG5807 332 IEEHNGTIEVESKPGKgTTFTIYLPLY 358
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
21-348 |
3.27e-50 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 170.47 E-value: 3.27e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 21 LLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLVIDGRSHILSVTAQRMP 100
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 101 DGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKAlPDPSLLEYTKVIIEQADRLRN 180
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-LDEEQREYLETILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 181 LVDRLL------GPQLPGTRVTESIHKVAERVVTLVSMELPD-NVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQAl 253
Cdd:COG0642 160 LINDLLdlsrleAGKLELEPEPVDLAELLEEVVELFRPLAEEkGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKY- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 254 GPEGGEIILRTRTafqltlHGERyrlaARIDVEDNGPGIPPHLQDTLFYPMV----SGREGGTGLGLSIARNLIDQHSGK 329
Cdd:COG0642 239 TPEGGTVTVSVRR------EGDR----VRISVEDTGPGIPPEDLERIFEPFFrtdpSRRGGGTGLGLAIVKRIVELHGGT 308
|
330 340
....*....|....*....|
gi 15834045 330 IEFTSWPGH-TEFSVYLPIR 348
Cdd:COG0642 309 IEVESEPGKgTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
114-349 |
4.25e-49 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 164.69 E-value: 4.25e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 114 QRRLSQEQLQHAQQvAARDLVRGLAHEIKNPLGGLRGAAQLLSK--ALPDPSLLEYTKVIIEQADRLRNLVDRLL----- 186
Cdd:COG2205 1 ELEEALEELEELER-LKSEFLANVSHELRTPLTSILGAAELLLDeeDLSPEERRELLEIIRESAERLLRLIEDLLdlsrl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 187 -GPQLPGTRVTESIHKVAERVVTLVSMELPD-NVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQAlGPEGGEIilrt 264
Cdd:COG2205 80 eSGKLSLELEPVDLAELLEEAVEELRPLAEEkGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKY-SPPGGTI---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 265 rtafqlTLHGERYRLAARIDVEDNGPGIPPHLQDTLFYPMV----SGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-T 339
Cdd:COG2205 155 ------TISARREGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGgT 228
|
250
....*....|
gi 15834045 340 EFSVYLPIRK 349
Cdd:COG2205 229 TFTVTLPLAE 238
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
12-347 |
1.96e-46 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 164.52 E-value: 1.96e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 12 ILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNI--ELMQESLEAGQGFTDNEVTLVIDGRS 89
Cdd:COG5805 162 LIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKEEfkERIESITEVWQEFIIEREIITKDGRI 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 90 HILSVTAQRMPDG-------MILLEmapmD-NQRRLSQEQLQH------AQQVAArdlvrGLAHEIKNPLGGLRGAAQLL 155
Cdd:COG5805 242 RYFEAVIVPLIDTdgsvkgiLVILR----DiTEKKEAEELMARseklsiAGQLAA-----GIAHEIRNPLTSIKGFLQLL 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 156 SKALPDPSllEYTKVIIEQADRLRNLVDRLLGPQLPGT--RVTESIHKVAERVVTLVSME-LPDNVRLIRDYDPSLPELA 232
Cdd:COG5805 313 QPGIEDKE--EYFDIMLSELDRIESIISEFLALAKPQAvnKEKENINELIQDVVTLLETEaILHNIQIRLELLDEDPFIY 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 233 HDPDQIEQVLLNIVRNALQALgPEGGEIILRTRTAFQltlhgeryrlAARIDVEDNGPGIPPHLQDTLFYPMVSGREGGT 312
Cdd:COG5805 391 CDENQIKQVFINLIKNAIEAM-PNGGTITIHTEEEDN----------SVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGT 459
|
330 340 350
....*....|....*....|....*....|....*.
gi 15834045 313 GLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
Cdd:COG5805 460 GLGLMVSYKIIENHNGTIDIDSKVGKgTTFTITLPL 495
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
11-349 |
3.84e-46 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 163.61 E-value: 3.84e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 11 QILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYF--SLNIELMQESLEAGQGFtDNEVTLV-IDG 87
Cdd:COG5809 145 LIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDdqENVAAFISQLLKDGGIA-QGEVRFWtKDG 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 88 RSHILSVT-AQRMPDG---MILLEMAPMDNQRRLsQEQLQHAQ------QVAArdlvrGLAHEIKNPLGGLRGAAQLLSK 157
Cdd:COG5809 224 RWRLLEASgAPIKKNGevdGIVIIFRDITERKKL-EELLRKSEklsvvgELAA-----GIAHEIRNPLTSLKGFIQLLKD 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 158 ALPDPSLlEYTKVIIEQADRLRNLVDRLLG---PQlpGTRVTE-SIHKVAERVVTLVSME-LPDNVRLIRDYDPSLPELA 232
Cdd:COG5809 298 TIDEEQK-TYLDIMLSELDRIESIISEFLVlakPQ--AIKYEPkDLNTLIEEVIPLLQPQaLLKNVQIELELEDDIPDIL 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 233 HDPDQIEQVLLNIVRNALQALgPEGGEIILRTRtafqltLHGERYrlaARIDVEDNGPGIPPHLQDTLFYPMVSGREGGT 312
Cdd:COG5809 375 GDENQLKQVFINLLKNAIEAM-PEGGNITIETK------AEDDDK---VVISVTDEGCGIPEERLKKLGEPFYTTKEKGT 444
|
330 340 350
....*....|....*....|....*....|....*...
gi 15834045 313 GLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIRK 349
Cdd:COG5809 445 GLGLMVSYKIIEEHGGKITVESEVGKgTTFSITLPIKL 482
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
11-349 |
6.75e-44 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 155.48 E-value: 6.75e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 11 QILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLVIDGRSH 90
Cdd:COG5002 53 ALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 91 ILSVTAQRMPDGMILLEMAPMDNQRRLSQEQLQhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQLL-SKALPDPSLL-EYT 168
Cdd:COG5002 133 RLSLRLSALLLGLLLLAAVERDITELERLEQMR-------REFVANVSHELRTPLTSIRGYLELLlDGAADDPEERrEYL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 169 KVIIEQADRLRNLVDRLL------GPQLPGTRVTESIHKVAERVVTLVSMELPD-NVRLIRDYDPSLPELAHDPDQIEQV 241
Cdd:COG5002 206 EIILEEAERLSRLVNDLLdlsrleSGELKLEKEPVDLAELLEEVVEELRPLAEEkGIELELDLPEDPLLVLGDPDRLEQV 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 242 LLNIVRNALQAlGPEGGEIILRtrtafqLTLHGERyrlaARIDVEDNGPGIPPHLQDTL---FY---PMVSGREGGTGLG 315
Cdd:COG5002 286 LTNLLDNAIKY-TPEGGTITVS------LREEDDQ----VRISVRDTGIGIPEEDLPRIferFYrvdKSRSRETGGTGLG 354
|
330 340 350
....*....|....*....|....*....|....*
gi 15834045 316 LSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIRK 349
Cdd:COG5002 355 LAIVKHIVEAHGGRIWVESEPGKgTTFTITLPLAR 389
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
114-348 |
7.11e-34 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 132.49 E-value: 7.11e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 114 QRRLSQEQLQHAQQV-AARDLVRGLAHEIKNPLGGLRGAAQL-LSKALPDPSLLEYTKVIIEQADRLRNLVDRLLGPQLP 191
Cdd:PRK13837 433 ERDALERRLEHARRLeAVGTLASGIAHNFNNILGAILGYAEMaLNKLARHSRAARYIDEIISAGARARLIIDQILAFGRK 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 192 GTRVTE--SIHKVAERVVTLVSMELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALGPEGG-EIILRTR--T 266
Cdd:PRK13837 513 GERNTKpfDLSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRvDISLSRAklR 592
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 267 AFQLTLHGE----RYrlaARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEF 341
Cdd:PRK13837 593 APKVLSHGVlppgRY---VLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRgTRF 669
|
....*..
gi 15834045 342 SVYLPIR 348
Cdd:PRK13837 670 DVYLPPS 676
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
113-349 |
7.77e-33 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 126.79 E-value: 7.77e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 113 NQRRLSQEQLQHAQQVAarDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQADRLRNLVDRLL------ 186
Cdd:COG5808 226 LERVIQEINTQKLELIG--TFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYFDIIQEEIQRINQIVSEFLvlgkpt 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 187 GPQLPGTRVTESIHKVAErvvTLVSMELPDNVRL-IRDYDPSLPELAhDPDQIEQVLLNIVRNALQALgPEGGEIILrtr 265
Cdd:COG5808 304 AKKLELDDLNELIEEILS---IIDSEANLKNIRVeKQSLDEPLHIKC-DKDRIKQVLLNLIKNAIEAM-KEGGKLTI--- 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 266 tafQLTLHGERyrlaARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVY 344
Cdd:COG5808 376 ---SIENDDEK----AVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKgTTFTIR 448
|
....*
gi 15834045 345 LPIRK 349
Cdd:COG5808 449 LPLKK 453
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
234-348 |
4.56e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 108.12 E-value: 4.56e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 234 DPDQIEQVLLNIVRNALQAlGPEGGEIILRTRTAfqltlhgeryRLAARIDVEDNGPGIPPHLQDTLFYPMVSGRE---- 309
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKY-TPEGGRITVTLERD----------GDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrsrk 70
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 15834045 310 -GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
Cdd:smart00387 71 iGGTGLGLSIVKKLVELHGGEISVESEPGGgTTFTITLPLE 111
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
115-347 |
6.16e-26 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 107.56 E-value: 6.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 115 RRLSQEQLQHAQQVAAR-DLVRGLAHEIKNPLGGLRGAAQLLSKALPDPS-LLEYTKVIIEQADRLRNLVDRLLGPQLPg 192
Cdd:PRK10364 221 RQLLQDEMKRKEKLVALgHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGeAHQLAQVMAKEADRLNRVVSELLELVKP- 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 193 TRVTES---IHKVAERVVTLVSMELPD-NVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALgPEGGEIilrtrtAF 268
Cdd:PRK10364 300 THLALQavdLNDLINHSLQLVSQDANSrEIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAI-GQHGVI------SV 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 269 QLTLHGERyrlaARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
Cdd:PRK10364 373 TASESGAG----VKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKgATFTLWLPV 448
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
120-346 |
9.82e-26 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 106.49 E-value: 9.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 120 EQLQHAQQVAArdlvrGLAHEIKNPLGGLRGAAQLL-SKALPDPSLLEYTKVIIEQADRLRNLVDRLLG---PQlPGTRV 195
Cdd:COG5806 196 EKLEVVSELAA-----SIAHEVRNPLTVVRGFIQLLqEPELSDEKRKQYIRIALEELDRAEAIITDYLTfakPQ-PEKLE 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 196 TESIHKVAERVVTLVS-MELPDNVRLIRDYDPSLpELAHDPDQIEQVLLNIVRNALQALgPEGGEiilrtrtafqLTLHG 274
Cdd:COG5806 270 KIDVSEELEHVIDVLSpYANMNNVEIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAM-PNGGT----------LTIDV 337
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15834045 275 ERYRLAARIDVEDNGPGIPP-HLQD--TLFYpmvSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
Cdd:COG5806 338 SIDKNKVIISIKDTGVGMTKeQLERlgEPYF---STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKgTTFTITLP 410
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
238-345 |
4.42e-25 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 97.29 E-value: 4.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQAlGPEGGEIILRTRTAFQltlhgeryrlAARIDVEDNGPGIPPHLQDTLFYPMVSGR----EGGTG 313
Cdd:cd00075 1 LEQVLSNLLDNALKY-SPPGGTIEISLRQEGD----------GVVLEVEDNGPGIPEEDLERIFERFYRGDksreGGGTG 69
|
90 100 110
....*....|....*....|....*....|...
gi 15834045 314 LGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYL 345
Cdd:cd00075 70 LGLAIVRRIVEAHGGRITVESEPGGgTTFTVTL 102
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
12-349 |
5.42e-25 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 104.16 E-value: 5.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 12 ILNSLINSILLIDDNLAIHYANPAAQQLLAQSsrkLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLVIDGRSHI 91
Cdd:COG3290 89 VLESIREGVIAVDRDGRITLINDAARRLLGLD---AIGRPIDEVLAEVLETGERDEEILLNGRVLVVNRVPIRDDGRVVG 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 92 LSVTAQRMpdgmillemapmdNQRRLSQEQLQHAQQVAarDLVRGLAHEIKNPLGGLRGAAQLLSkalpDPSLLEYTKVI 171
Cdd:COG3290 166 AVATFRDR-------------TELERLEEELEGVKELA--EALRAQRHDFRNHLHTISGLLQLGE----YDEALEYIDEI 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 172 IEQADRLRNLVDRLLGPQLPGTRVTESIHKVAERvvtlvsmelpdNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQ 251
Cdd:COG3290 227 SEELQELIDSLLSRIGNPVLAALLLGKAARARER-----------GIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIE 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 252 A---LGPEGGEIILRtrtafqLTLHGERYRlaarIDVEDNGPGIPPHLQDTLFYPMVSGREG-GTGLGLSIARNLIDQHS 327
Cdd:COG3290 296 AvekLPEEERRVELS------IRDDGDELV----IEVEDSGPGIPEELLEKIFERGFSTKLGeGRGLGLALVKQIVEKYG 365
|
330 340
....*....|....*....|...
gi 15834045 328 GKIEFTSWPGH-TEFSVYLPIRK 349
Cdd:COG3290 366 GTIEVESEEGEgTVFTVRLPKEG 388
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
134-332 |
6.74e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 104.93 E-value: 6.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 134 VRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQADRLRNLVDRLL------GPQLPGTRVTESIHKVAERVV 207
Cdd:PRK11100 260 VQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLelarleQRQELEVLEPVALAALLEELV 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 208 TLVSMELP-DNVRLirDYDPSLPELAHDPDQIEQVLLNIVRNALqALGPEGGEIILRtrtafqLTLHGERYRLAaridVE 286
Cdd:PRK11100 340 EAREAQAAaKGITL--RLRPDDARVLGDPFLLRQALGNLLDNAI-DFSPEGGTITLS------AEVDGEQVALS----VE 406
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 15834045 287 DNGPGIPPHLQDTL---FY--PMVSGREGGTGLGLSIARNLIDQHSGKIEF 332
Cdd:PRK11100 407 DQGPGIPDYALPRIferFYslPRPANGRKSTGLGLAFVREVARLHGGEVTL 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
8-349 |
1.75e-24 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 104.10 E-value: 1.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 8 DAGQILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLVIDG 87
Cdd:COG4251 150 LLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLL 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 88 RSHILSVTAQRMPDGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVR----------GLAHEIKNPLGGLRGAAQLLSK 157
Cdd:COG4251 230 LLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERsneeleqfayVASHDLREPLRKISGFSQLLEE 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 158 AL---PDPSLLEYTKVIIEQADRLRNLVDRLL------GPQLPGTRVteSIHKVAERVVTLVSMELPD-NVRLIRDydpS 227
Cdd:COG4251 310 DYgdkLDEEGREYLERIRDAAERMQALIDDLLaysrvgRQELEFEPV--DLNELLEEVLEDLEPRIEErGAEIEVG---P 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 228 LPELAHDPDQIEQVLLNIVRNALQALGP-EGGEIILRTRtafqltLHGERYRlaarIDVEDNGPGIPPHLQDTLFYPM-- 304
Cdd:COG4251 385 LPTVRGDPTLLRQVFQNLISNAIKYSRPgEPPRIEIGAE------REGGEWV----FSVRDNGIGIDPEYAEKIFEIFqr 454
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15834045 305 VSGRE--GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIRK 349
Cdd:COG4251 455 LHSRDeyEGTGIGLAIVKKIVERHGGRIWVESEPGEgATFYFTLPKAP 502
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
234-349 |
1.06e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 91.28 E-value: 1.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 234 DPDQIEQVLLNIVRNALQAlGPEGGEIILRTRTAFQLtlhgeryrlaaRIDVEDNGPGIPPHLQDTLFYPMVSG---REG 310
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKH-AAKAGEITVTLSEGGEL-----------TLTVEDNGIGIPPEDLPRIFEPFSTAdkrGGG 69
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 15834045 311 GTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIRK 349
Cdd:pfam02518 70 GTGLGLSIVRKLVELLGGTITVESEPGGgTTVTLTLPLAQ 109
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
238-346 |
2.04e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 90.24 E-value: 2.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQaLGPEGgEIILRTRTafqLTLHGERYRLaaRIDVEDNGPGIPPHLQDTLFYPMV------SGREGG 311
Cdd:cd16922 1 LRQILLNLLGNAIK-FTEEG-EVTLRVSL---EEEEEDGVQL--RFSVEDTGIGIPEEQQARLFEPFSqadsstTRKYGG 73
|
90 100 110
....*....|....*....|....*....|....*.
gi 15834045 312 TGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
Cdd:cd16922 74 TGLGLAISKKLVELMGGDISVESEPGQgSTFTFTLP 109
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
137-349 |
7.38e-21 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 93.82 E-value: 7.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 137 LAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQADRLRNLVDRLL---GPQLPGTRVTESIHKVAERVVTLVSME 213
Cdd:PRK11466 451 MSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILdysAIEAGGKNVSVSDEPFEPRPLLESTLQ 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 214 LPDN------VRLIRDYDPSLPE-LAHDPDQIEQVLLNIVRNALQAlgPEGGEIILRTRTAFQLTLhgeryrlaarIDVE 286
Cdd:PRK11466 531 LMSGrvkgrpIRLATDIADDLPTaLMGDPRRIRQVITNLLSNALRF--TDEGSIVLRSRTDGEQWL----------VEVE 598
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15834045 287 DNGPGIPPHLQDTLFYPMV--SGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIRK 349
Cdd:PRK11466 599 DSGCGIDPAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVgSCFCLRLPLRV 664
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
235-347 |
1.40e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 85.17 E-value: 1.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 235 PDQIEQVLLNIVRNALQALGpEGGEIILRTrtafqlTLHGERyrlaARIDVEDNGPGIPPHLQDTLFYPMVSGREG--GT 312
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAME-GRGRITIRT------WAHVDQ----VLIEVEDTGSGIDPEILGRIFDPFFTTKPVgeGT 69
|
90 100 110
....*....|....*....|....*....|....*.
gi 15834045 313 GLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
Cdd:cd16943 70 GLGLSLSYRIIQKHGGTIRVASVPGGgTRFTIILPI 105
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
9.74e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 80.13 E-value: 9.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQAL---GPEGGEIILRTRTAfqltlhGERYrlaARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGL 314
Cdd:cd16920 1 IQQVLINLVRNGIEAMsegGCERRELTIRTSPA------DDRA---VTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGM 71
|
90 100 110
....*....|....*....|....*....|...
gi 15834045 315 GLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLP 346
Cdd:cd16920 72 GLSICRSIIEAHGGRLSVESPAgGGATFQFTLP 104
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
115-347 |
2.72e-18 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 85.88 E-value: 2.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 115 RRLSQEQLQHAQQVAAR-DLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLeyTKVIIEQADRLRNLVDR-------LL 186
Cdd:PRK13557 147 RRDAEDALRQAQKMEALgQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDAD--RGRMARSVENIRAAAERaatltqqLL 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 187 G----PQLPGtRVTeSIHKVAERVVTLVSMELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALgPEGGEIIL 262
Cdd:PRK13557 225 AfarkQRLEG-RVL-NLNGLVSGMGELAERTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAM-PEGGRVTI 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 263 RTR--------TAFQLTLHGERYrlaARIDVEDNGPGIPPHLQDTLFYPMVSGR-EG-GTGLGLSIARNLIDQHSGKIEF 332
Cdd:PRK13557 302 RTRnveiededLAMYHGLPPGRY---VSIAVTDTGSGMPPEILARVMDPFFTTKeEGkGTGLGLSMVYGFAKQSGGAVRI 378
|
250
....*....|....*.
gi 15834045 333 TSWPGH-TEFSVYLPI 347
Cdd:PRK13557 379 YSEVGEgTTVRLYFPA 394
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-337 |
9.39e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 69.49 E-value: 9.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 234 DPDQIEQVLLNIVRNALQALgpEG-----GEIILRTRTAFQLTLhgeryrlaaRIDVEDNGPGIPPHLQDTLFYPMVSGR 308
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAI--EGrpsdvGEVRIRVEADQDGRI---------VLIVCDNGKGFPREMRHRATEPYVTTR 69
|
90 100
....*....|....*....|....*....
gi 15834045 309 EGGTGLGLSIARNLIDQHSGKIEFTSWPG 337
Cdd:cd16944 70 PKGTGLGLAIVKKIMEEHGGRISLSNREA 98
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
116-347 |
1.68e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 73.83 E-value: 1.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 116 RLSQEQLQHAQQVAARD-LVRGLAHEIKNPLGGLRGAAQ---LLSKALPDPSLLEYTKVIIEQADRLRNLVDRLLGPQLP 191
Cdd:PRK09303 136 VLRQENETLLEQLKFKDrVLAMLAHDLRTPLTAASLALEtleLGQIDEDTELKPALIEQLQDQARRQLEEIERLITDLLE 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 192 GTRVTESIHKVAERVVTL------VSMELPD-----NVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQaLGPEGGEI 260
Cdd:PRK09303 216 VGRTRWEALRFNPQKLDLgslcqeVILELEKrwlakSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIK-YTPEGGTI 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 261 IL----RTRTAFQLTlhgeryrlaaridVEDNGPGIPPHLQDTLFYPMV----SGREGGTGLGLSIARNLIDQHSGKIEF 332
Cdd:PRK09303 295 TLsmlhRTTQKVQVS-------------ICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRIVRVHYGQIWV 361
|
250
....*....|....*.
gi 15834045 333 TSWPGH-TEFSVYLPI 347
Cdd:PRK09303 362 DSEPGQgSCFHFTLPV 377
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
15-348 |
5.22e-14 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 72.35 E-value: 5.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 15 SLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQesleagQGFTDnEVTLVIDGRSHilsV 94
Cdd:PRK11006 106 SLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEFTQYLKT------RDFSR-PLTLVLNNGRH---L 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 95 TAQRMP--DGMILLEMapmdnqRRLSQ-EQLQHAQqvaaRDLVRGLAHEIKNPLGGLRGAAQLLS-KALPDPSLLEYTKV 170
Cdd:PRK11006 176 EIRVMPytEGQLLMVA------RDVTQmHQLEGAR----RNFFANVSHELRTPLTVLQGYLEMMQdQPLEGALREKALHT 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 171 IIEQADRLRNLVDRLL-------GPQLPGTRVTE--SIHKVAERVVTLVSMElpdNVRLIRDYDPSLPELAHDpDQIEQV 241
Cdd:PRK11006 246 MREQTQRMEGLVKQLLtlskieaAPTIDLNEKVDvpMMLRVLEREAQTLSQG---KHTITFEVDNSLKVFGNE-DQLRSA 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 242 LLNIVRNALQALgPEGGEIILRtrtaFQLTLHGeryrlaARIDVEDNGPGIPP-HLQDTL--FYPMVSGRE---GGTGLG 315
Cdd:PRK11006 322 ISNLVYNAVNHT-PEGTHITVR----WQRVPQG------AEFSVEDNGPGIAPeHIPRLTerFYRVDKARSrqtGGSGLG 390
|
330 340 350
....*....|....*....|....*....|....
gi 15834045 316 LSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
Cdd:PRK11006 391 LAIVKHALSHHDSRLEIESEVGKgTRFSFVLPER 424
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
239-346 |
8.65e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 67.02 E-value: 8.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 239 EQVLLNIVRNALQALgPEGGEIILRTRTAFQLTLHGERYR--LAAR---IDVEDNGPGIPPHLQDTLFYPMVSGRE--GG 311
Cdd:cd16919 2 ELAILNLAVNARDAM-PEGGRLTIETSNQRVDADYALNYRdlIPGNyvcLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 15834045 312 TGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVgTTVRIYLP 116
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
234-346 |
2.76e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 65.59 E-value: 2.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 234 DPDQIEQVLLNIVRNALQAlGPEGGEIILRtrtafqLTLHGERYRLaarIDVEDNGPGIPPHLQDTLFYPMVSGRE---- 309
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKF-TPDGGRIRCI------LEKFRLNRFL---LTVSDSGPGIPPNLREEIFERFRQGDGsstr 70
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 15834045 310 --GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
Cdd:cd16925 71 ahGGTGLGLSIVKEFVELHGGTVTVSDAPGGgALFQVELP 110
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
13-346 |
3.05e-13 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 70.33 E-value: 3.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 13 LNSLINSILLIDDNLAIHYANPAAQQLLAQSSrKLFGTPLPELLSYFSLNIELmQESLEAGQGFTDNEVTlvIDGRShIL 92
Cdd:PRK11086 227 LQSIKEGVIAVDDRGEVTLINDEAKRLFNYKK-GLEDDPLGTDVESWMPVSRL-KEVLRTGTPRRDEEIN--INGRL-LL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 93 svtAQRMP---DGMILLEMAPMDNQRRLSQ--EQLQHAQQVAarDLVRGLAHEIKNPLGGLRGAAQLlsKALPDpsLLEY 167
Cdd:PRK11086 302 ---TNTVPvrvNGEIIGAIATFRDKTEVRQlaQRLDGMVNYA--DALRAQSHEFMNKLHVILGLLHL--KSYDQ--LEDY 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 168 TKVI-IEQADRLRNLVDRLLGPQLPG------TRVTESihkvaervvtlvsmelpdNVRLIRDYDPSLPElAHDPDQIEQ 240
Cdd:PRK11086 373 ILKTaNNYQEEIGSLLGKIKSPVIAGfllgkiSRAREL------------------GITLIISEDSQLPD-SGDEDQVHE 433
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 241 ---VLLNIVRNALQALGP-EGGEIilrtrtafQLTLHGERYRLAarIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGL 316
Cdd:PRK11086 434 litILGNLIENALEAVGGeEGGEI--------SVSLHYRNGWLH--CEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGL 503
|
330 340 350
....*....|....*....|....*....|.
gi 15834045 317 SIARNLIDQHSGKIEFTSWPG-HTEFSVYLP 346
Cdd:PRK11086 504 YLVKQSVENLGGSIAVESEPGvGTQFFVQIP 534
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
3.68e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 64.78 E-value: 3.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQAlgpEGGEIILRTRTAfqltlhGERyrlaARIDVEDNGPGIPPHLQDTLFYPMVSGRE----GGTG 313
Cdd:cd16950 1 LKRVLSNLVDNALRY---GGGWVEVSSDGE------GNR----TRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTG 67
|
90 100 110
....*....|....*....|....*....|....
gi 15834045 314 LGLSIARNLIDQHSGKIEF-TSWPGHTEFSVYLP 346
Cdd:cd16950 68 LGLAIVQRISDAHGGSLTLaNRAGGGLCARIELP 101
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
87-347 |
7.96e-13 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 68.78 E-value: 7.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 87 GRSHILSVTA--QRMPDGMILLEmapmdNQRRLsqeqlqhaqqvaardLVRGLAHEIKNPLGGLRGAAQLLSkalPDPSL 164
Cdd:PRK09467 204 GASEVRSVTRafNQMAAGIKQLE-----DDRTL---------------LMAGVSHDLRTPLTRIRLATEMMS---EEDGY 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 165 L--------EYTKVIIEQ-ADRLRnlvdrllgPQLPGTRVTESIHKVAERVVtlvSMELPDNVRLIRDYDPSLPELAHDP 235
Cdd:PRK09467 261 LaesinkdiEECNAIIEQfIDYLR--------TGQEMPMEMADLNALLGEVI---AAESGYEREIETALQPGPIEVPMNP 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 236 DQIEQVLLNIVRNALQaLGpeGGEIILRTRTAFQLtlhgeryrlaARIDVEDNGPGIPPHLQDTLFYPMVSGREG----G 311
Cdd:PRK09467 330 IAIKRALANLVVNAAR-YG--NGWIKVSSGTEGKR----------AWFQVEDDGPGIPPEQLKHLFQPFTRGDSArgssG 396
|
250 260 270
....*....|....*....|....*....|....*..
gi 15834045 312 TGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLPI 347
Cdd:PRK09467 397 TGLGLAIVKRIVDQHNGKVELGNSEeGGLSARAWLPL 433
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
131-186 |
8.47e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 62.61 E-value: 8.47e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 15834045 131 RDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQADRLRNLVDRLL 186
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLL 58
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
2.60e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 62.34 E-value: 2.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQalgpeggeiILRTRTAFQLTLHGERYRLAARIDVEDNGPGIPPHLQDTLF--YPMVSGRE--GGTG 313
Cdd:cd16921 1 LGQVLTNLLGNAIK---------FRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFgiFQRLHSREeyEGTG 71
|
90 100 110
....*....|....*....|....*....|....
gi 15834045 314 LGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
Cdd:cd16921 72 VGLAIVRKIIERHGGRIWLESEPGEgTTFYFTLP 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-346 |
2.69e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 62.30 E-value: 2.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 244 NIVRNALQALGPEGGEiilRTRTAFQLTLHGEryrlAARIDVEDNGPGIPPHLQDTLFYPMVSGRE-GGTGLGLSIARNL 322
Cdd:cd16915 7 NLIDNALDALAATGAP---NKQVEVFLRDEGD----DLVIEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 15834045 323 IDQHSGKIEFTS-WPGHTEFSVYLP 346
Cdd:cd16915 80 VERLGGSITVESePGGGTTFSIRIP 104
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
7.20e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 61.29 E-value: 7.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQALgpeggeiilRTRTAFQLTLHGERyrlaARIDVEDNGPGIPPHLQDTLFYPMV---SGRE---GG 311
Cdd:cd16939 1 MARALDNLLRNALRYA---------HRTVRIALLVSGGR----LTLIVEDDGPGIPAAARERVFEPFVrldPSRDratGG 67
|
90 100 110
....*....|....*....|....*....|....*.
gi 15834045 312 TGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLP 346
Cdd:cd16939 68 FGLGLAIVHRVALWHGGHVECDDSElGGACFRLTWP 103
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-349 |
8.94e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 61.06 E-value: 8.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 244 NIVRNALQaLGPEGGEIILRtrtaFQLTLHGeryrlaARIDVEDNGPGIPPHLQDTL---FYPMVSGR---EGGTGLGLS 317
Cdd:cd16952 7 NLVSNAVK-YTPPSDTITVR----WSQEESG------ARLSVEDTGPGIPPEHIPRLterFYRVDIERcrnTGGTGLGLA 75
|
90 100 110
....*....|....*....|....*....|...
gi 15834045 318 IARNLIDQHSGKIEFTSWPGH-TEFSVYLPIRK 349
Cdd:cd16952 76 IVKHVMSRHDARLLIASELGKgSRFTCLFPSSR 108
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
112-330 |
1.07e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 65.86 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 112 DNQRRLSQEQLQHAQQVAAR-DLVRGLAHEIKNPLGGLRGAAQLLSKAL---PDPSLLEYTKVIIEQADRLRNLVDRL-- 185
Cdd:COG4192 414 EKNLRQTQDELIQAAKMAVVgQTMTSLAHELNQPLNAMSMYLFSAKKALeqeNYAQLPTSLDKIEGLIERMDKIIKSLrq 493
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 186 LGPQLPGTRVTESIHKVAERVVTLVsmELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALgPEGGEIILrtr 265
Cdd:COG4192 494 FSRKSDTPLQPVDLRQVIEQAWELV--ESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAV-ATQPQISV--- 567
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15834045 266 tafQLTLHGERYRLAaridVEDNGPGIPphLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKI 330
Cdd:COG4192 568 ---DLLSNAENLRVA----ISDNGNGWP--LVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDL 623
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-336 |
2.15e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 60.17 E-value: 2.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 234 DPDQIEQVLLNIVRNALQALGPeGGEIILRTRTAFQltlhgeryrlAARIDVEDNGPGIPPHLQDTL---FYPMVSGRE- 309
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDT-GGKLRIRAAQTPQ----------EVRLDVEDSAPGVSDDQLARLferFYRVESSRNr 69
|
90 100
....*....|....*....|....*....
gi 15834045 310 --GGTGLGLSIARNLIDQHSGKIEFTSWP 336
Cdd:cd16946 70 asGGSGLGLAICHNIALAHGGTISAEHSP 98
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-345 |
2.92e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.39 E-value: 2.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQALGPeggeiILRTRTAFQLTLHGERYRLAaridVEDNGPGIPPHLQDTLFYPMVSGRE--GGTGLG 315
Cdd:cd16976 1 IQQVLMNLLQNALDAMGK-----VENPRIRIAARRLGGRLVLV----VRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLG 71
|
90 100 110
....*....|....*....|....*....|.
gi 15834045 316 LSIARNLIDQHSGKIEFTSW-PGHTEFSVYL 345
Cdd:cd16976 72 LSISYGIVEEHGGRLSVANEeGAGARFTFDL 102
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
131-186 |
3.04e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 58.35 E-value: 3.04e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 15834045 131 RDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQADRLRNLVDRLL 186
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLL 58
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
139-348 |
3.63e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 64.49 E-value: 3.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 139 HEIKNPLGGLRG-AAQLLSKALpDPSLLEYTKVIIEQADRLRNLV-DRLLGPQL-PGTRVTESI----HKVAERVVTLVS 211
Cdd:PRK11107 302 HELRTPLNGVIGfTRQTLKTPL-TPTQRDYLQTIERSANNLLAIInDILDFSKLeAGKLVLENIpfslRETLDEVVTLLA 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 212 -------MELPDNVrlirdyDPSLPE-LAHDPDQIEQVLLNIVRNALQAlgPEGGEIILRTRTAfqlTLHGERYRLaaRI 283
Cdd:PRK11107 381 hsahekgLELTLNI------DPDVPDnVIGDPLRLQQIITNLVGNAIKF--TESGNIDILVELR---ALSNTKVQL--EV 447
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15834045 284 DVEDNGPGIPPHLQDTLFYPM------VSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
Cdd:PRK11107 448 QIRDTGIGISERQQSQLFQAFrqadasISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRgSTFWFHLPLD 519
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
131-186 |
7.70e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 57.22 E-value: 7.70e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 15834045 131 RDLVRGLAHEIKNPLGGLRGAAQLL-SKALPDPSLLEYTKVIIEQADRLRNLVDRLL 186
Cdd:cd00082 5 GEFLANVSHELRTPLTAIRGALELLeEELLDDEEQREYLERIREEAERLLRLINDLL 61
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-330 |
8.12e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 58.11 E-value: 8.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQVLLNIVRNALQaLGPEggeiilrtrtafQLTLHGERYRLAARIDVEDNGPGIPPHLQDTLFYPMV---SGRE---GG 311
Cdd:cd16949 1 LARALENVLRNALR-YSPS------------KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdSARDresGG 67
|
90
....*....|....*....
gi 15834045 312 TGLGLSIARNLIDQHSGKI 330
Cdd:cd16949 68 TGLGLAIAERAIEQHGGKI 86
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-330 |
2.54e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 57.20 E-value: 2.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 240 QVLLNIVRNALQALGPEGGEIILRtrtafqLTLHGERYRLAaridVEDNGPGIPPHLQDTLFYPMVSGREGG------TG 313
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTGRITVS------AMPTGKMVTIS----VEDEGPGIPQEKLESIFDRFYTERPANeafgqhSG 72
|
90
....*....|....*..
gi 15834045 314 LGLSIARNLIDQHSGKI 330
Cdd:cd16953 73 LGLSISRQIIEAHGGIS 89
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-337 |
3.18e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 57.03 E-value: 3.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 234 DPDQIEQVLLNIVRNALQaLGPEGGEIILRTRTafqltlhgeryRLAARIDVEDNGPGIPPHLQDTL---FYPMVSGREG 310
Cdd:cd16940 10 DALLLFLLLRNLVDNAVR-YSPQGSRVEIKLSA-----------DDGAVIRVEDNGPGIDEEELEALferFYRSDGQNYG 77
|
90 100
....*....|....*....|....*..
gi 15834045 311 GTGLGLSIARNLIDQHSGKIEFTSWPG 337
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQG 104
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
123-347 |
4.49e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 61.20 E-value: 4.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 123 QHAQQVAAR--DLVRGLAHEIKNPLGGLRGAAQLLSKALPDP--------------SLLEytkvIIEqadrlrNLVD--R 184
Cdd:PRK15347 389 QRAEQANKRksEHLTTISHEIRTPLNGVLGALELLQNTPLTAeqmdladtarqctlSLLA----IIN------NLLDfsR 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 185 LLGPQLPGTRVTESIHKVAERVV-TLVSMELPDNVRLIRDYDPSLPELAH-DPDQIEQVLLNIVRNALQAlgPEGGEIIL 262
Cdd:PRK15347 459 IESGQMTLSLEETALLPLLDQAMlTIQGPAQSKSLTLRTFVGAHVPLYLHlDSLRLRQILVNLLGNAVKF--TETGGIRL 536
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 263 RTRTafqltlhgERYRLAarIDVEDNGPGIPPHLQDTLFYPM--VSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-T 339
Cdd:PRK15347 537 RVKR--------HEQQLC--FTVEDTGCGIDIQQQQQIFTPFyqADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVgS 606
|
....*...
gi 15834045 340 EFSVYLPI 347
Cdd:PRK15347 607 CFSLVLPL 614
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
113-330 |
7.83e-10 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 59.95 E-value: 7.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 113 NQRRLSQEQLQHAQQVaardLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYtkviIE-QADRLRNLVDRLLgpQLP 191
Cdd:PRK09470 230 NQMVTALERMMTSQQR----LLSDISHELRTPLTRLQLATALLRRRQGESKELER----IEtEAQRLDSMINDLL--VLS 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 192 G-------TRVTESIHKVAERVVTLVSMELPD-NVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQalgpeggeiilR 263
Cdd:PRK09470 300 RnqqknhlERETFKANSLWSEVLEDAKFEAEQmGKSLTVSAPPGPWPINGNPNALASALENIVRNALR-----------Y 368
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15834045 264 TRTAFQLTLHGERYRLaaRIDVEDNGPGIPPHLQDTLFYPM--VS---GRE-GGTGLGLSIARNLIDQHSGKI 330
Cdd:PRK09470 369 SHTKIEVAFSVDKDGL--TITVDDDGPGVPEEEREQIFRPFyrVDearDREsGGTGLGLAIVENAIQQHRGWV 439
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
92-348 |
1.71e-09 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 58.85 E-value: 1.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 92 LSVTAQRMPDGMiLLEMAPMDNQR---RLSQEQLQHAQQVAA-----RDLVRGLAHEIKNPLGGLRGAAQLlSKALPDPS 163
Cdd:PRK10604 167 LEAAAQRLGDGH-LAERIHFDEGSsleRLGVAFNQMADNINAliaskKQLIDGIAHELRTPLVRLRYRLEM-SDNLSAAE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 164 LLEYTKVIieqaDRLRNLVDRLLG------PQLPgtrvtesihkvaervVTLVSMELP-------DNVRLIR-----DYD 225
Cdd:PRK10604 245 SQALNRDI----GQLEALIEELLTyarldrPQNE---------------LHLSEPDLPawlsthlADIQAVTpektvRLD 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 226 PSLPEL--AHDPDQIEQVLLNIVRNALQALGpeggeiilrTRTAFQLTLHGERYRLaariDVEDNGPGIPPHLQDTLFYP 303
Cdd:PRK10604 306 TPHQGDygALDMRLMERVLDNLLNNALRYAH---------SRVRVSLLLDGNQACL----IVEDDGPGIPPEERERVFEP 372
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 15834045 304 MV---SGRE---GGTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLPIR 348
Cdd:PRK10604 373 FVrldPSRDratGGCGLGLAIVHSIALAMGGSVNCDESElGGARFSFSWPVW 424
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
107-349 |
1.79e-09 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 59.28 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 107 EMAPMDNQRrlsqEQLQHAqqvaardLVRGLAHEIKNPLGGLRGAAQLLSKALPdpslLEYTKVIiEQADRLRN------ 180
Cdd:PRK10490 652 EQARLASER----EQLRNA-------LLAALSHDLRTPLTVLFGQAEILTLDLA----SEGSPHA-RQASEIRQqvlntt 715
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 181 -LVDRLLGP---QLPGTRVTESIHKVAERV-VTLVSMELPDNVRLIRdydPSLPE---LAH-DPDQIEQVLLNIVRNALQ 251
Cdd:PRK10490 716 rLVNNLLDMariQSGGFNLRKEWLTLEEVVgSALQMLEPGLSGHPIN---LSLPEpltLIHvDGPLFERVLINLLENAVK 792
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 252 ALGpEGGEIILRTRTAFQlTLHgeryrlaarIDVEDNGPGIPPHLQDTLFYPMVSGREG----GTGLGLSIARNLIDQHS 327
Cdd:PRK10490 793 YAG-AQAEIGIDAHVEGE-RLQ---------LDVWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHG 861
|
250 260
....*....|....*....|...
gi 15834045 328 GKIEFTSWP-GHTEFSVYLPIRK 349
Cdd:PRK10490 862 GTIWAENRPeGGACFRVTLPLET 884
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
215-346 |
1.96e-08 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 55.72 E-value: 1.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 215 PDNVRLIRDYDPSLPELAH-DPDQIEQVLLNIVRNALQAlgPEGGEIILRTRtafqltlHGERYRLaaRIDVEDNGPGIP 293
Cdd:PRK11091 375 QKGLRFDLEPLLPLPHKVItDGTRLRQILWNLISNAVKF--TQQGGVTVRVR-------YEEGDML--TFEVEDSGIGIP 443
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15834045 294 PHLQDTLF--YPMVSGREG-----GTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
Cdd:PRK11091 444 EDELDKIFamYYQVKDSHGgkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKgSCFTLTIH 504
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
102-331 |
3.25e-08 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 54.91 E-value: 3.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 102 GMILLEMAPMDNQRRLSQEQLQHAQQ--VAARDLVRGLA-------HEIKNPLGGLRGAAQLL----SKALPDPSLLEYT 168
Cdd:TIGR02938 239 PYLLLTIADISNLREEQERARLSALQalMAEEERLEAIRetlsaaiHRLQGPMNLISAAISVLqrrgDDAGNPASAAMLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 169 KVIIEQADRLRNLvdRLLGPQLPG-TRVTESIHKVAERVVTLVSMELPDNvRLIRDYDPS--LPELAHDPDQIEQVLLNI 245
Cdd:TIGR02938 319 QALSAGREHMEAL--RQVIPQSPQeIVVPVNLNQILRDVITLSTPRLLAA-GIVVDWQPAatLPAILGRELQLRSLFKAL 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 246 VRNALQALGPEGG---EIILRTRTAFQLTlhgeryrlaaRIDVEDNGPGIPPHLQDTLFYPMVSGREG---GTGLGLSIA 319
Cdd:TIGR02938 396 VDNAIEAMNIKGWkrrELSITTALNGDLI----------VVSILDSGPGIPQDLRYKVFEPFFTTKGGsrkHIGMGLSVA 465
|
250
....*....|..
gi 15834045 320 RNLIDQHSGKIE 331
Cdd:TIGR02938 466 QEIVADHGGIID 477
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-337 |
3.57e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 50.92 E-value: 3.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 234 DPDQIEQVLLNIVRNALqALGPEGGEIILRTRtafqltLHGEryrlAARIDVEDNGPGIPPHLQDTLF-----YPMVSGR 308
Cdd:cd16945 1 DPFLLRQAINNLLDNAI-DFSPEGGLIALQLE------ADTE----GIELLVFDEGSGIPDYALNRVFerfysLPRPHSG 69
|
90 100
....*....|....*....|....*....
gi 15834045 309 EGGTGLGLSIARNLIDQHSGKIEFTSWPG 337
Cdd:cd16945 70 QKSTGLGLAFVQEVAQLHGGRITLRNRPD 98
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
225-347 |
8.38e-08 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 53.82 E-value: 8.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 225 DPSLPE-LAHDPDQIEQVLLNIVRNALQAlgPEGGEIILRTRTAfqltlHGERYrlaarIDVEDNGPGIPPHLQDTLFYP 303
Cdd:PRK10841 549 EPDVPVaLNGDPMRLQQVISNLLSNAIKF--TDTGCIVLHVRVD-----GDYLS-----FRVRDTGVGIPAKEVVRLFDP 616
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 15834045 304 MVSGREG------GTGLGLSIARNLIDQHSGKIEFTSWPG-HTEFSVYLPI 347
Cdd:PRK10841 617 FFQVGTGvqrnfqGTGLGLAICEKLINMMDGDISVDSEPGmGSQFTIRIPL 667
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
128-347 |
5.99e-07 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 51.27 E-value: 5.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 128 VAARDLVRGLAHEIKNPLGGLRGAAQLLS-KALPDPSLLEYTKVIIEQADRLRNLVDRLLG------------PQ---LP 191
Cdd:PRK09959 710 VAKSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEQRVEAISLAYATGQSLLGLIGEILDvdkiesgnyqlqPQwvdIP 789
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 192 gTRVTESIHK----VAERVVTL-VSMELPDNVrLIRDydpslpelahDPDQIEQVLLNIVRNALQalgpeggeiiLRTRT 266
Cdd:PRK09959 790 -TLVQNTCHSfgaiAASKSIALsCSSTFPDHY-LVKI----------DPQAFKQVLSNLLSNALK----------FTTEG 847
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 267 AFQLT---LHGERYRLAARIDVEDNGPGIPPHLQDTLF--YPMVSG--REGGTGLGLSIARNLIDQHSGKIEFTSWPG-H 338
Cdd:PRK09959 848 AVKITtslGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFkrYSQTSAgrQQTGSGLGLMICKELIKNMQGDLSLESHPGiG 927
|
....*....
gi 15834045 339 TEFSVYLPI 347
Cdd:PRK09959 928 TTFTITIPV 936
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
102-349 |
6.41e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 50.00 E-value: 6.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 102 GMILLEMAPMDNQRRLSQEQLQHAQQVA-------ARDLVRGLAHEiknpLGGLRGAAQLLSKALP--DPSLLEYTKVII 172
Cdd:COG4585 23 ALVLLRARRAERAAELERELAARAEEAReeerrriARELHDGVGQS----LSAIKLQLEAARRLLDadPEAAREELEEIR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 173 EQADR----LRNLVDRLLGPQLPGTRVTESIHKVAERVVTLVSMElpdnVRLirDYDPSLPELahdPDQIEQVLLNIVRN 248
Cdd:COG4585 99 ELAREalaeLRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIR----VEL--DVDGDPDRL---PPEVELALYRIVQE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 249 AL-------QAlgpeggeiilrTRTAFQLTLHGERYRLaariDVEDNGPGIPPhlqdtlfypmvsGREGGTGLGLSIARN 321
Cdd:COG4585 170 ALtnalkhaGA-----------TRVTVTLEVDDGELTL----TVRDDGVGFDP------------EAAPGGGLGLRGMRE 222
|
250 260
....*....|....*....|....*....
gi 15834045 322 LIDQHSGKIEFTSWPGH-TEFSVYLPIRK 349
Cdd:COG4585 223 RAEALGGTLTIGSAPGGgTRVRATLPLAA 251
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
131-330 |
1.17e-06 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 50.02 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 131 RDLVRGLAHEIKNPLGGLRGAAQLLSKAL--PDP----SLLeyTKVIIeqadrLRNLVDRL----------LGPQLPGTR 194
Cdd:PRK10549 241 RDFMADISHELRTPLAVLRGELEAIQDGVrkFTPesvaSLQ--AEVGT-----LTKLVDDLhqlslsdegaLAYRKTPVD 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 195 VTESI--------HKVAERVVTLvSMELPDNVRLIrdydpslpelaHDPDQIEQVLLNIVRNALQALGPEGGEIILRTRT 266
Cdd:PRK10549 314 LVPLLevaggafrERFASRGLTL-QLSLPDSATVF-----------GDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQR 381
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 267 AFQLTLHgeryrlaaridVEDNGPGI-PPHLQDTL--FYPMVSGR---EGGTGLGLSIARNLIDQHSGKI 330
Cdd:PRK10549 382 DKTLRLT-----------FADSAPGVsDEQLQKLFerFYRTEGSRnraSGGSGLGLAICLNIVEAHNGRI 440
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
8-349 |
4.06e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 48.36 E-value: 4.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 8 DAGQILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLVIDG 87
Cdd:COG3920 172 LAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLG 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 88 RSHILSVTAQRMPDGMILLEMAPMDNQRRLSQEQLQHAQQVAARD-LVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLE 166
Cdd:COG3920 252 RLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKElLLRELHHRVKNNLQVVSSLLRLQARRADDPEARE 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 167 YTKVIIeqaDRLR--NLVDRLLGPQLPGTRVteSIHKVAERVVT-LVSMELPDNVRLIRDydpsLPELAHDPDQIEQV-- 241
Cdd:COG3920 332 ALEESQ---NRIQalALVHELLYQSEDWEGV--DLRDYLRELLEpLRDSYGGRGIRIELD----GPDVELPADAAVPLgl 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 242 LLN-IVRNALQ--ALGPEGGEIILRtrtafqLTLHGERYRLaariDVEDNGPGIPPHLQdtlfypmvsgREGGTGLGLSI 318
Cdd:COG3920 403 ILNeLVTNALKhaFLSGEGGRIRVS------WRREDGRLRL----TVSDNGVGLPEDVD----------PPARKGLGLRL 462
|
330 340 350
....*....|....*....|....*....|.
gi 15834045 319 ARNLIDQHSGKIEFTSWPGhTEFSVYLPIRK 349
Cdd:COG3920 463 IRALVRQLGGTLELDRPEG-TRVRITFPLAE 492
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-345 |
4.65e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 45.20 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 234 DPDQIEQVLLNIVRNALQaLGPEGGEIilrtrtafQLTLHGERYRLAarIDVEDNGPGIPPHLQDTLF---YPMVSGREG 310
Cdd:cd16947 17 NTEALQRILKNLISNAIK-YGSDGKFL--------GMTLREDEKHVY--IDIWDKGKGISETEKDHVFerlYTLEDSRNS 85
|
90 100 110
....*....|....*....|....*....|....*....
gi 15834045 311 ---GTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYL 345
Cdd:cd16947 86 akqGNGLGLTITKRLAESMGGSIYVNSKPYEkTVFTVTL 124
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
281-346 |
5.72e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 44.30 E-value: 5.72e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 281 ARIDVEDNGPGIPPHLQDTLFYPMVSGRE----GGTGLGLSIARNLIDQHSGKIEFTSWPGHTEFSVYLP 346
Cdd:cd16923 33 VNIMFKNPSSHPLDFKLEKLFERFYRGDNsrntEGAGLGLSIAKAIIELHGGSASAEYDDNHDLFKVRLP 102
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
11-74 |
5.86e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 43.54 E-value: 5.86e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15834045 11 QILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLniELMQESLEAGQ 74
Cdd:smart00091 5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDR--ERVQEALQRLL 66
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
282-336 |
6.34e-06 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 47.71 E-value: 6.34e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 282 RIDVEDNGPGIPPHLQDTLFypmVSGREG-----GTGLGLSIARNLIDQHSGKIEFTSWP 336
Cdd:PRK10815 410 HIVVEDDGPGIPESKRELIF---DRGQRAdtlrpGQGLGLSVAREITEQYEGKISAGDSP 466
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
215-347 |
6.85e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.90 E-value: 6.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 215 PDNVRLIRDY-DPSLPELAHDPDQIEQVLL-------NIVRNALQalGPEGGEIILRtrtafqLTLHGERYRlaarIDVE 286
Cdd:COG2172 8 LEDLGLARRAvRALLRELGLDEDDADDLVLavseavtNAVRHAYG--GDPDGPVEVE------LELDPDGLE----IEVR 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15834045 287 DNGPGIPP-HLQDtlfyPMVSGREGgtGLGLSIARNLIDQhsgkIEFTSWPGHTEFSVYLPI 347
Cdd:COG2172 76 DEGPGFDPeDLPD----PYSTLAEG--GRGLFLIRRLMDE----VEYESDPGGTTVRLVKRL 127
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
217-345 |
1.30e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 44.16 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 217 NVRLIRDYDPSLPELAHDPDQIEqVLLNIVRNAlqalgpeggeiilrtrtaFQLTLhgERYRLAAR-------IDVEDNG 289
Cdd:cd16954 18 GVSISLDISPELRFPGERNDLME-LLGNLLDNA------------------CKWCL--EFVEVTARqtdgglhLIVDDDG 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15834045 290 PGIPPHLQDTLFYPMVSGREG--GTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYL 345
Cdd:cd16954 77 PGVPESQRSKIFQRGQRLDEQrpGQGLGLAIAKEIVEQYGGELSLSDSPlGGARFEVVF 135
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
137-346 |
1.31e-05 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 46.69 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 137 LAHEIKNPLGGLRGAAQL-LSKALPDPSLLEYTKVIIEQADRLRNLVDRLL------GPQLPGTRVT----ESIHKV--- 202
Cdd:PRK09835 269 IAHEIRTPITNLITQTEIaLSQSRSQKELEDVLYSNLEELTRMAKMVSDMLflaqadNNQLIPEKKMldlaDEVGKVfdf 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 203 -----AERVVTLvsmelpdnvrlirDYDPSLPELAHDPDQIEQVLLNIVRNALQALgPEGGEIILRTRTAFQltlhgery 277
Cdd:PRK09835 349 feawaEERGVEL-------------RFVGDPCQVAGDPLMLRRAISNLLSNALRYT-PAGEAITVRCQEVDH-------- 406
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15834045 278 rlAARIDVEDNGPGIPP-HLQDTL--FYPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGHTEFSVYLP 346
Cdd:PRK09835 407 --QVQLVVENPGTPIAPeHLPRLFdrFYRVDPSRQrkgEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLP 479
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
16-102 |
1.44e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 43.39 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 16 LINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLN--IELMQESLEAGQGFTDNEVTLVIDGRSHILS 93
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREelRERLENLLSGGEPVTLEVRLRRKDGSVIWVL 80
|
....*....
gi 15834045 94 VTAQRMPDG 102
Cdd:cd00130 81 VSLTPIRDE 89
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
124-337 |
1.84e-05 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 46.18 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 124 HAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQA-DRLRNLVDRLLG--------------- 187
Cdd:PRK10337 231 HAMMVRERRFTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGiDRATRLVDQLLTlsrldsldnlqdvae 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 188 ---PQLPGTRVTESIHKvAERVVTLVSMELPDnVRLIRDYDPSLPELahdpdqieqVLLNIVRNALQaLGPEGGEIilrt 264
Cdd:PRK10337 311 iplEDLLQSAVMDIYHT-AQQAGIDVRLTLNA-HPVIRTGQPLLLSL---------LVRNLLDNAIR-YSPQGSVV---- 374
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15834045 265 rtafQLTLHGERYRlaaridVEDNGPGIPPHLQDTL---FYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPG 337
Cdd:PRK10337 375 ----DVTLNARNFT------VRDNGPGVTPEALARIgerFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPE 440
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
138-329 |
4.79e-05 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 44.57 E-value: 4.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 138 AHEIKNPLGGLRGAAQLLSKA-LPDPSLLeytkviIEQADRLRNLVDRLLgpQLpgTRVTESIH-------KVAERVVTL 209
Cdd:PRK10755 145 AHELRTPLAGIRLHLELLEKQhHIDVAPL------IARLDQMMHTVEQLL--QL--ARAGQSFSsghyqtvKLLEDVILP 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 210 VSMELPD-----NVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQaLGPEGGEIILRtrtafqLTLHGERYRLAarid 284
Cdd:PRK10755 215 SQDELSEmleqrQQTLLLPESAADITVQGDATLLRLLLRNLVENAHR-YSPEGSTITIK------LSQEDGGAVLA---- 283
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 15834045 285 VEDNGPGIPP-HLQDTL--FYPMVSgREGGTGLGLSIARNLIDQHSGK 329
Cdd:PRK10755 284 VEDEGPGIDEsKCGELSkaFVRMDS-RYGGIGLGLSIVSRITQLHHGQ 330
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
11-99 |
6.21e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 41.63 E-value: 6.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 11 QILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLS--YFSLNIELMQESLEAGQGFTDNEVTLVI-DG 87
Cdd:pfam00989 5 AILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPeeDDAEVAELLRQALLQGEESRGFEVSFRVpDG 84
|
90
....*....|..
gi 15834045 88 RSHILSVTAQRM 99
Cdd:pfam00989 85 RPRHVEVRASPV 96
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
238-346 |
2.42e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 39.96 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 238 IEQvllnIVRNALQaLGPEGGEIILRTRTAFQLTLhgeryrlaarIDVEDNGPGIPPhlQDT--LFYPMVSGREG----- 310
Cdd:cd16948 10 IGQ----IVSNALK-YSKQGGKIEIYSETNEQGVV----------LSIKDFGIGIPE--EDLprVFDKGFTGENGrnfqe 72
|
90 100 110
....*....|....*....|....*....|....*..
gi 15834045 311 GTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
Cdd:cd16948 73 STGMGLYLVKKLCDKLGHKIDVESEVGEgTTFTITFP 109
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
212-349 |
2.59e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 42.70 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 212 MELPDNVRLIRDYDPSLPELaHDPDQIEQVLL-NIVRNALQALgPEGGEIILRTRtafqltLHGERyrlaARIDVEDNGP 290
Cdd:COG2972 315 LRFGDRLEVEIEIDEELLDL-LIPKLILQPLVeNAIEHGIEPK-EGGGTIRISIR------KEGDR----LVITVEDNGV 382
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15834045 291 GIPPHLQDTLFYPMvSGREGGTGLGLSIARNLIDQHSGK---IEFTSWPGH-TEFSVYLPIRK 349
Cdd:COG2972 383 GMPEEKLEKLLEEL-SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEgTTVTIRIPLEE 444
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
228-346 |
1.50e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 40.20 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 228 LPElAHDPDQIEQVLLNIVRNALQA--LGPEGGEIIlrtrtafQLTLHGERYRLAarIDVEDNGPGIPPHLQDTLFYPMV 305
Cdd:PRK15053 424 LPP-GLDSTEFAAIVGNLLDNAFEAslRSDEGNKIV-------ELFLSDEGDDVV--IEVADQGCGVPESLRDKIFEQGV 493
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 15834045 306 SGR---EGGTGLGLSIARNLIDQHSGKIEFT-SWPGHTEFSVYLP 346
Cdd:PRK15053 494 STRadePGEHGIGLYLIASYVTRCGGVITLEdNDPCGTLFSIFIP 538
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-330 |
3.15e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 36.67 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834045 234 DPDQIEQVLLNIVRNALQaLGPEGGEIilrtrtafQLTLHGERYRLaaRIDVEDNGPGIPPH---LQDTLFYPMVSGREG 310
Cdd:cd16975 1 DTLLLSRALINIISNACQ-YAPEGGTV--------SISIYDEEEYL--YFEIWDNGHGFSEQdlkKALELFYRDDTSRRS 69
|
90 100
....*....|....*....|..
gi 15834045 311 GT--GLGLSIARNLIDQHSGKI 330
Cdd:cd16975 70 GGhyGMGLYIAKNLVEKHGGSL 91
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
11-68 |
4.90e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 35.22 E-value: 4.90e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 15834045 11 QILNSLINSILLIDDNLAIHYANPAAQQLL-AQSSRKLFGTPLPELLSYFSLNIELMQE 68
Cdd:pfam13188 5 ALFESSPDGILVLDEGGRIIYVNPAALELLgYELLGELLGELLDLLDPLLEDALELLRE 63
|
|
| |
