|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
10-364 |
0e+00 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 635.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 10 PISLRQRLILTIGAILLVFELISVFWLWHESTEQIQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLFICYQ 89
Cdd:PRK10755 1 MISLRRRLLLTIGLILLVFQLISVFWLWHESTEQIQLLVQATLSARNNDEHVMKEIREAVASLLVPSLVMVSLTLLICFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 90 AVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLE 169
Cdd:PRK10755 81 AVRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 170 LLAKTHHIDVAPLVARLDQMMESVSQLLQLARAGQSFSSGNYQHVKLLEDVILPSYDELSTMLDQRQQTLLLPESAADIT 249
Cdd:PRK10755 161 LLEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVILPSQDELSEMLEQRQQTLLLPESAADIT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 250 VQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQED-GGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIV 328
Cdd:PRK10755 241 VQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEdGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIV 320
|
330 340 350
....*....|....*....|....*....|....*.
gi 1447699860 329 SRITQLHHGQFFLQNRQETSGTRAWVRLKKDQNVAN 364
Cdd:PRK10755 321 SRITQLHHGQFFLQNRQERSGTRAWVWLPKAQNVAN 356
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-356 |
2.46e-54 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 174.52 E-value: 2.46e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 244 SAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAVMAVEDEGPGIDESKCGELSKAFVRMDSR-YGGIG 322
Cdd:cd16940 1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQnYGGSG 80
|
90 100 110
....*....|....*....|....*....|....
gi 1447699860 323 LGLSIVSRITQLHHGQFFLQNRQeTSGTRAWVRL 356
Cdd:cd16940 81 LGLSIVKRIVELHGGQIFLGNAQ-GGGLEAWVRL 113
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
1-361 |
7.14e-44 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 155.87 E-value: 7.14e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 1 MNLMRFLRRPISLRQRLILTIGAILLVFELISVFWLWHESTEQIQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMV 80
Cdd:COG5002 20 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 81 SLTLFICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTP 160
Cdd:COG5002 100 ALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 161 LAGVRLHLELLAKTHHIDVAPLVARLDQMMES-------VSQLLQLARAGQSFSSGNYQHV---KLLEDVIlpsyDELST 230
Cdd:COG5002 180 LTSIRGYLELLLDGAADDPEERREYLEIILEEaerlsrlVNDLLDLSRLESGELKLEKEPVdlaELLEEVV----EELRP 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 231 MLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDGGAVMAVEDEGPGIDESKCGELSK 309
Cdd:COG5002 256 LAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLrEEDDQVRISVRDTGIGIPEEDLPRIFE 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1447699860 310 AFVRMDS----RYGGIGLGLSIVSRITQLHHGQFFLQNRQEtSGTRAWVRLKKDQN 361
Cdd:COG5002 336 RFYRVDKsrsrETGGTGLGLAIVKHIVEAHGGRIWVESEPG-KGTTFTITLPLARE 390
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
44-356 |
1.23e-43 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 153.91 E-value: 1.23e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 44 IQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATL 123
Cdd:COG0642 8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 124 EIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLELLAKTHHIDVAPLVARL----DQMMESVSQLLQL 199
Cdd:COG0642 88 LLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETIlrsaDRLLRLINDLLDL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 200 ARAGQSFSSGNYQHV---KLLEDVIlpsyDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGS 276
Cdd:COG0642 168 SRLEAGKLELEPEPVdlaELLEEVV----ELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 277 NIMIKLQEDGGAVM-AVEDEGPGIDESKCGELSKAFVRMDS--RYGGIGLGLSIVSRITQLHHGQFFLQNRQETsGTRAW 353
Cdd:COG0642 244 TVTVSVRREGDRVRiSVEDTGPGIPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGK-GTTFT 322
|
...
gi 1447699860 354 VRL 356
Cdd:COG0642 323 VTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
149-356 |
1.70e-41 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 145.43 E-value: 1.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 149 FTADVAHELRTPLAGVRLHLELLAKTHHIDVAPLVARLDQMMES-------VSQLLQLARAGQSFSSGNYQHVKLlEDVI 221
Cdd:COG2205 19 FLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESaerllrlIEDLLDLSRLESGKLSLELEPVDL-AELL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 222 LPSYDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDGGAVMAVEDEGPGID 300
Cdd:COG2205 98 EEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISArREGDGVRISVSDNGPGIP 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1447699860 301 ESKCGELSKAFVRMDS--RYGGIGLGLSIVSRITQLHHGQFFLQNRqETSGTRAWVRL 356
Cdd:COG2205 178 EEELERIFERFYRGDNsrGEGGTGLGLAIVKRIVEAHGGTIWVESE-PGGGTTFTVTL 234
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
69-346 |
3.31e-36 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 136.70 E-value: 3.31e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 69 VASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTLDNERL 148
Cdd:PRK10337 160 VAGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 149 FTADVAHELRTPLAGVRLHLElLAKTHHID-------VAPLVARLDQMMESVSQLLQLARAgQSFSSgnyqhvklLEDVI 221
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTE-VAQLSDDDpqarkkaLLQLHAGIDRATRLVDQLLTLSRL-DSLDN--------LQDVA 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 222 LPSYDEL--STMLDQ---RQQ---TLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGgavMAVE 293
Cdd:PRK10337 310 EIPLEDLlqSAVMDIyhtAQQagiDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN---FTVR 386
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1447699860 294 DEGPGIDESKCGELSKAFVRMDSR-YGGIGLGLSIVSRITQLHHGQFFLQNRQE 346
Cdd:PRK10337 387 DNGPGVTPEALARIGERFYRPPGQeATGSGLGLSIVRRIAKLHGMNVSFGNAPE 440
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
85-338 |
9.71e-28 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 111.15 E-value: 9.71e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 85 FICYQAVRRITRPLaelqkELEARTADNLTpIAIHSATLEIEAVVSALNDlVSRLTSTLDNERLFTADVAHELRTPLAGV 164
Cdd:TIGR02966 60 FVEYLAAGRFSEPL-----ELPSPINSERV-LEIRIAPYGEEQKLLVARD-VTRLRRLEQMRRDFVANVSHELRTPLTVL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 165 RLHLELLAKTHHIDvaPLVAR--LDQM------MES-VSQLLQLARAGQSFSSGNYQHVKLLEdVILPSYDELSTMLDQR 235
Cdd:TIGR02966 133 RGYLETLADGPDED--PEEWNraLEIMleqsqrMQSlVEDLLTLSRLESAASPLEDEPVDMPA-LLDHLRDEAEALSQGK 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 236 QQTLLLpESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQED-GGAVMAVEDEGPGIDESKCGELSKAFVRM 314
Cdd:TIGR02966 210 NHQITF-EIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDgGGAEFSVTDTGIGIAPEHLPRLTERFYRV 288
|
250 260
....*....|....*....|....*...
gi 1447699860 315 D---SR-YGGIGLGLSIVSRITQLHHGQ 338
Cdd:TIGR02966 289 DksrSRdTGGTGLGLAIVKHVLSRHHAR 316
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
91-356 |
2.58e-25 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 106.15 E-value: 2.58e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 91 VRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLvSRLTSTLDNER-LFTADVAHELRTPLAGVRLHLE 169
Cdd:PRK09467 174 IRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQM-AAGIKQLEDDRtLLMAGVSHDLRTPLTRIRLATE 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 170 LLAKTHHIDVAPLVARLDQMMESVSQLLQLARAGQSFSSGNYQHVKLLEDVILpsydelSTMLDQRQQTLLLPESAADIT 249
Cdd:PRK09467 253 MMSEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNALLGEVIA------AESGYEREIETALQPGPIEVP 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 250 VQGDAtlLRMLLRNLVENAHRYSpqGSNIMIKLQEDGGAV-MAVEDEGPGIDESKCGELSKAFVRMDSRYG--GIGLGLS 326
Cdd:PRK09467 327 MNPIA--IKRALANLVVNAARYG--NGWIKVSSGTEGKRAwFQVEDDGPGIPPEQLKHLFQPFTRGDSARGssGTGLGLA 402
|
250 260 270
....*....|....*....|....*....|
gi 1447699860 327 IVSRITQLHHGQFFLQNRQEtSGTRAWVRL 356
Cdd:PRK09467 403 IVKRIVDQHNGKVELGNSEE-GGLSARAWL 431
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
252-360 |
9.90e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 97.05 E-value: 9.90e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 252 GDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAVMAVEDEGPGIDESKCGELSKAFVRMDSR-YGGIGLGLSIVSR 330
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgGGGTGLGLSIVRK 80
|
90 100 110
....*....|....*....|....*....|
gi 1447699860 331 ITQLHHGQFFLQNRqETSGTRAWVRLKKDQ 360
Cdd:pfam02518 81 LVELLGGTITVESE-PGGGTTVTLTLPLAQ 109
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
84-356 |
2.13e-24 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 103.12 E-value: 2.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 84 LFICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLvsrlTSTLDNERL-----FTADVAHELR 158
Cdd:COG5000 138 LLPELDLAELLREALERGWQEEIELTRDGRRTLLVRASPLRDDGYVIVFDDI----TELLRAERLaawgeLARRIAHEIK 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 159 TPLAGVRLHLELLAKTHHIDVAP-----------LVARLDQMMESVSQLLQLARAGQSfssgNYQHV---KLLEDVIlps 224
Cdd:COG5000 214 NPLTPIQLSAERLRRKLADKLEEdredleraldtIIRQVDRLKRIVDEFLDFARLPEP----QLEPVdlnELLREVL--- 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 225 yDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDGGAVMAVEDEGPGIDESk 303
Cdd:COG5000 287 -ALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTrREDGRVRIEVSDNGPGIPEE- 364
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1447699860 304 cgELSKAFVR-MDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQETsGTRAWVRL 356
Cdd:COG5000 365 --VLERIFEPfFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGG-GTTFTIRL 415
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
55-337 |
1.11e-23 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 101.70 E-value: 1.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 55 RNNDRHIMREIREAvasLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNL-TPIAIHSATLEIEAVVSALN 133
Cdd:TIGR01386 152 INAHTHLLDALRKW---LILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLdQRLDPSRAPAELRELAQSFN 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 134 DLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLElLAKTHHIDVAPLVA----------RLDQMmesVSQLLQLARAG 203
Cdd:TIGR01386 229 AMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQ-VALSQPRTGEEYREvlesnleeleRLSRM---VSDMLFLARAD 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 204 QSFSSGNYQHVKL---LEDVIlpsyDELSTMLDQRQQTLLLPESAadiTVQGDATLLRMLLRNLVENAHRYSPQGSNIMI 280
Cdd:TIGR01386 305 NGQLALERVRLDLaaeLAKVA----EYFEPLAEERGVRIRVEGEG---LVRGDPQMFRRAISNLLSNALRHTPDGGTITV 377
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1447699860 281 KLQEDGGAV-MAVEDEGPGIDESKCGELSKAFVRMD-SRYG---GIGLGLSIVSRITQLHHG 337
Cdd:TIGR01386 378 RIERRSDEVrVSVSNPGPGIPPEHLSRLFDRFYRVDpARSNsgeGTGLGLAIVRSIMEAHGG 439
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
154-359 |
6.37e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 99.53 E-value: 6.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 154 AHELRTPLAGVRLHLELLAK----------THHIDVAPlvARLDQMMEsvsQLLQLARAGQSfssgnyQHVKLLEDVILP 223
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEdpppedrarfTGNILTQS--ARLQQLID---RLLELARLEQR------QELEVLEPVALA 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 224 S-YDELSTMLDQR--QQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAV-MAVEDEGPGI 299
Cdd:PRK11100 333 AlLEELVEAREAQaaAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVaLSVEDQGPGI 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1447699860 300 DESKCGELSKAF---VRMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQEtSGTRAWVRLKKD 359
Cdd:PRK11100 413 PDYALPRIFERFyslPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPE-GGVLATLTLPRH 474
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
252-358 |
2.00e-22 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 90.79 E-value: 2.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 252 GDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAV-MAVEDEGPGIDESKCGELSKAFVRMD---SRYGGIGLGLSI 327
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVeITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 1447699860 328 VSRITQLHHGQFFLQNRqETSGTRAWVRLKK 358
Cdd:smart00387 81 VKKLVELHGGEISVESE-PGGGTTFTITLPL 110
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
5-361 |
4.62e-22 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 97.16 E-value: 4.62e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 5 RFLRRPISLRQRLILTIGAILLVFELISVFWLWHESTEQIQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTL 84
Cdd:COG4251 141 ALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLS 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 85 FICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTldNERL--FTADVAHELRTPLA 162
Cdd:COG4251 221 LGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERS--NEELeqFAYVASHDLREPLR 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 163 GVRLHLELLAKTH----------HIDVAplVARLDQMMESVSQLLQLARAGQSfsSGNYQHV---KLLEDVIlpsyDELS 229
Cdd:COG4251 299 KISGFSQLLEEDYgdkldeegreYLERI--RDAAERMQALIDDLLAYSRVGRQ--ELEFEPVdlnELLEEVL----EDLE 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 230 TMLDQRQQTLllpESAADITVQGDATLLRMLLRNLVENAHRYSPQGSN--IMIKLQEDGGAVM-AVEDEGPGIDESKCGE 306
Cdd:COG4251 371 PRIEERGAEI---EVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVfSVRDNGIGIDPEYAEK 447
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1447699860 307 LSKAFVRMDSR--YGGIGLGLSIVSRITQLHHGQFFLQNrQETSGTRAWVRLKKDQN 361
Cdd:COG4251 448 IFEIFQRLHSRdeYEGTGIGLAIVKKIVERHGGRIWVES-EPGEGATFYFTLPKAPA 503
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
51-337 |
6.60e-21 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 93.35 E-value: 6.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 51 LRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEArtADNLTPIAIHSATlEIEAVVS 130
Cdd:NF012163 148 ERLTRNTDINFDSQQKRASWLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAA--GDYTTRVTPTSND-ELGKLAQ 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 131 ALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLELLA----KTHHIDVAPLVARLDQMMESVSQLLQLARAGQSF 206
Cdd:NF012163 225 DFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQdgirKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGA 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 207 SSGNYQHVKLLEdVILPSYDELSTMLDQRQQTLLLpESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-QED 285
Cdd:NF012163 305 LAYQKASVDLVP-LLEVEGGAFRERFASAGLELEV-SLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAsQRP 382
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1447699860 286 GGAVMAVEDEGPGIDESKCGELSKAFVRMDSRY----GGIGLGLSIVSRITQLHHG 337
Cdd:NF012163 383 KEVTLTVADSAPGVSDEQLARLFERFYRVEVSRnrasGGSGLGLAISLNIVQAHGG 438
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
65-338 |
2.05e-20 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 92.14 E-value: 2.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 65 IREAVASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNL-TPIAIHSATLEIEAVVSALNDLVSRLTSTL 143
Cdd:PRK09835 180 INDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLdVRLDPQTVPIELEQLVLSFNHMIERIEDVF 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 144 DNERLFTADVAHELRTPLAGVRLHLEL-LAKTHHI----DVapLVARLDQ---MMESVSQLLQLARAGqsfssgNYQHVk 215
Cdd:PRK09835 260 TRQSNFSADIAHEIRTPITNLITQTEIaLSQSRSQkeleDV--LYSNLEEltrMAKMVSDMLFLAQAD------NNQLI- 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 216 lLEDVILPSYDELSTMLD-------QRQQTLLLPESAAdiTVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGA 288
Cdd:PRK09835 331 -PEKKMLDLADEVGKVFDffeawaeERGVELRFVGDPC--QVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQ 407
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1447699860 289 V-MAVEDEGPGIDESKCGELSKAFVRMD---SRYG-GIGLGLSIVSRITQLHHGQ 338
Cdd:PRK09835 408 VqLVVENPGTPIAPEHLPRLFDRFYRVDpsrQRKGeGSGIGLAIVKSIVVAHKGT 462
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
92-337 |
8.20e-20 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 90.38 E-value: 8.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 92 RRITRPLAELQKELEARTADNLtpiAIH----SATLEIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLH 167
Cdd:PRK09470 188 WSLAKPARKLKNAADEVAQGNL---RQHpeleTGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLA 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 168 LELL-------AKTHHIDVAplVARLDQMmesVSQLLQLARAgqsfssgnyQHVKLLEDVILPSYDELSTMLD------- 233
Cdd:PRK09470 265 TALLrrrqgesKELERIETE--AQRLDSM---INDLLVLSRN---------QQKNHLERETFKANSLWSEVLEdakfeae 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 234 QRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDgGAVMAVEDEGPGIDESKCGELSKAFVR 313
Cdd:PRK09470 331 QMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKD-GLTITVDDDGPGVPEEEREQIFRPFYR 409
|
250 260
....*....|....*....|....*...
gi 1447699860 314 MDS----RYGGIGLGLSIVSRITQLHHG 337
Cdd:PRK09470 410 VDEardrESGGTGLGLAIVENAIQQHRG 437
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
82-348 |
3.74e-19 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 87.36 E-value: 3.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 82 LTLFICYQAVRRITRP---LAELQKE-----LEARTADNltpiAIHSAtlEIEAVVSALNDLVSRLTSTLDNERLFTADV 153
Cdd:NF012226 72 ISLIIGMKLAQRFIVPinfLADAAKKisqgdLSARAEDS----QIHSA--EISELMHNFNDMAQKLESSVKNAQVWNAAI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 154 AHELRTP---LAGvRLHlELLAKTHHIDVAPLVARLDQmMESVSQLLQLARAGQSFSSG----NYQHVKLLEDVilpsyD 226
Cdd:NF012226 146 AHELRTPitiLQG-RLQ-GILDGVFEPDPALFKSLLNQ-VEGLSHLVEDLRTLSLVENQqlrlNYESVDLKDSI-----E 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 227 ELSTMLDQR-QQTLLLPEsaADIT---VQGDATLLRMLLRNLVENAHRYSPQGS-NIMIKLQEDgGAVMAVEDEGPGIDE 301
Cdd:NF012226 218 KVLKMFEDRlEQAQLTIV--LNLTatpVFCDRRRIEQVLIALIDNAIRYANAGKlKISSSVIQD-DWILQIEDEGPGIAE 294
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1447699860 302 SKCGELSKAFVRM-DSR---YGGIGLGLSIVSRITQLHHGQFFLQNRQETS 348
Cdd:NF012226 295 EYQQDLFNPFFRLeQSRnkeFGGTGLGLAVVHAIVIAHKGSIEYSNSQGNS 345
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
67-356 |
4.04e-19 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 89.03 E-value: 4.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 67 EAVASLIVPGVFMVSLTLFIcyQAVR---RITRplaeLQKELEArTADNLTPI--AIHSATL--EIEAVVSALNDLVSRL 139
Cdd:TIGR03785 406 EKLFNVILAIMSIGTLALFG--FASWiswRIRR----LSDDAEA-AIDSQGRIsgAIPASRSrdEIGDLSRSFAQMVARL 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 140 TSTLDNERLFTADVAHELRTPLAGVRLHLELLA-------KTHHIDVAPL-VARLDQMMESVSqllQLARAGQSFSSGNY 211
Cdd:TIGR03785 479 RQYTHYLENMSSRLSHELRTPVAVVRSSLENLElqaleqeKQKYLERAREgTERLSMILNNMS---EATRLEQAIQSAEV 555
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 212 QHVKLLEdvILPSYDELSTMLDQRQQ-TLLLPESaaDITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDGGAV 289
Cdd:TIGR03785 556 EDFDLSE--VLSGCMQGYQMTYPPQRfELNIPET--PLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLsQNKSHAL 631
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447699860 290 MAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRITQLHHGQFFLQNRQETSGTRAWVRL 356
Cdd:TIGR03785 632 LTVSNEGPPLPEDMGEQLFDSMVSVrdqgAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNDGVVFRISL 702
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
147-338 |
1.74e-18 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 86.22 E-value: 1.74e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 147 RLFTADVAHELRTPLAGVRLHLELL----------AKTHHIdvapLVARLDQMMESVSQLLQLARAGQSfssgnyQHVKL 216
Cdd:PRK11006 205 RNFFANVSHELRTPLTVLQGYLEMMqdqplegalrEKALHT----MREQTQRMEGLVKQLLTLSKIEAA------PTIDL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 217 LEDVILPSYDEL----STMLDQRQQTLLLpESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQE-DGGAVMA 291
Cdd:PRK11006 275 NEKVDVPMMLRVlereAQTLSQGKHTITF-EVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRvPQGAEFS 353
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1447699860 292 VEDEGPGIDESKCGELSKAFVRMD---SRY-GGIGLGLSIVSRITQLHHGQ 338
Cdd:PRK11006 354 VEDNGPGIAPEHIPRLTERFYRVDkarSRQtGGSGLGLAIVKHALSHHDSR 404
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
138-337 |
8.95e-18 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 84.30 E-value: 8.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 138 RLTSTLD-NE---RLFTADVAHELRTPLAGVRLHLELLA----KTHHIDVAPL---VARLDQMMESVSQLLQLARAGQSF 206
Cdd:PRK10549 228 QLASTLEkNEqmrRDFMADISHELRTPLAVLRGELEAIQdgvrKFTPESVASLqaeVGTLTKLVDDLHQLSLSDEGALAY 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 207 SSGNYQHVKLLEdVILPSYDELstmLDQRQQTL--LLPESAadiTVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-Q 283
Cdd:PRK10549 308 RKTPVDLVPLLE-VAGGAFRER---FASRGLTLqlSLPDSA---TVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAeQ 380
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1447699860 284 EDGGAVMAVEDEGPGIDESKCGELSKAFVRMD-SR---YGGIGLGLSIVSRITQLHHG 337
Cdd:PRK10549 381 RDKTLRLTFADSAPGVSDEQLQKLFERFYRTEgSRnraSGGSGLGLAICLNIVEAHNG 438
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
153-338 |
3.73e-17 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 82.34 E-value: 3.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 153 VAHELRTPLAGVRLHLELLAKTHHIDVAPLVARLDQMMESVSQLLQLARAGQsfssgnyQHVKL-LEDVILPSY-----D 226
Cdd:PRK10604 219 IAHELRTPLVRLRYRLEMSDNLSAAESQALNRDIGQLEALIEELLTYARLDR-------PQNELhLSEPDLPAWlsthlA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 227 ELSTMLDQRQQTLLLPESAADITVqgDATLLRMLLRNLVENAHRYSpqGSNIMIKLQEDGG-AVMAVEDEGPGIDESKCG 305
Cdd:PRK10604 292 DIQAVTPEKTVRLDTPHQGDYGAL--DMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNqACLIVEDDGPGIPPEERE 367
|
170 180 190
....*....|....*....|....*....|....*..
gi 1447699860 306 ELSKAFVRMD-SR---YGGIGLGLSIVSRITQLHHGQ 338
Cdd:PRK10604 368 RVFEPFVRLDpSRdraTGGCGLGLAIVHSIALAMGGS 404
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
14-356 |
1.53e-16 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 79.84 E-value: 1.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 14 RQRLILTIGAILLVFELISVFWLWHESTEQIQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLFICYQAVRR 93
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 94 ITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTST----LDNERL-----FTADVAHELRTPLAGV 164
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELqeqlVQSEKLaalgeLAAGIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 165 RLHLELLAK--THHIDVAPLVARLDQMMES-------VSQLLQLARAgqsfSSGNYQHV---KLLEDVIlpsyDELSTML 232
Cdd:COG4191 161 LGNAELLRRrlEDEPDPEELREALERILEGaeraaeiVRSLRAFSRR----DEEEREPVdlnELIDEAL----ELLRPRL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 233 DQRQQTLLLPESAADITVQGDATLLRMLLRNLVENA-----HRYSPQgsnIMIKLQEDGGAVM-AVEDEGPGIDESkcgE 306
Cdd:COG4191 233 KARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAidameEGEGGR---ITISTRREGDYVViSVRDNGPGIPPE---V 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1447699860 307 LSKAFvrmD------SRYGGIGLGLSIVSRITQLHHGQFFLQNRQEtSGTRAWVRL 356
Cdd:COG4191 307 LERIF---EpffttkPVGKGTGLGLSISYGIVEKHGGRIEVESEPG-GGTTFTITL 358
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
145-338 |
5.60e-16 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 78.86 E-value: 5.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 145 NERL-----FTADVAHELRTPLAGVRLHLELLAKTHHIDVAP----LVARLDQMMESVSQLLQLARAgqsfSSGNYQHV- 214
Cdd:COG5809 264 SEKLsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTyldiMLSELDRIESIISEFLVLAKP----QAIKYEPKd 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 215 --KLLEDVIlpsydelstmldqrqqTLLLP-----------ESAADIT-VQGDATLLRMLLRNLVENAHRYSPQGSNIMI 280
Cdd:COG5809 340 lnTLIEEVI----------------PLLQPqallknvqielELEDDIPdILGDENQLKQVFINLLKNAIEAMPEGGNITI 403
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 281 --KLQEDGGAVMAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQ 338
Cdd:COG5809 404 etKAEDDDKVVISVTDEGCGIPEERLKKLGEPF--YTTKEKGTGLGLMVSYKIIEEHGGK 461
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
143-338 |
9.96e-16 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 78.26 E-value: 9.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 143 LDNER-LFTADVAHELRTPLAGVRLHLELLA----KTHhiDVAP--L-VAR--LDQMMESVSQLLQLARagqsFSSGNYQ 212
Cdd:NF033092 368 IEQERrEFVANVSHELRTPLTTMRSYLEALAdgawKDP--ELAPrfLgVTQneTERMIRLVNDLLQLSR----MDSKDYK 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 213 -------HVKLLEDVIlpsyDELSTMLDQRQQTLL--LPESaaDITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQ 283
Cdd:NF033092 442 lnkewvnFNEFFNYII----DRFEMILKNKNITFKreFPKR--DLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLL 515
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 284 EDGG-AVMAVEDEGPGIDESKCGELSKAFVRMD---SR-YGGIGLGLSIVSRITQLHHGQ 338
Cdd:NF033092 516 ETHNrIIISISDQGLGIPKKDLDKIFDRFYRVDkarSRkMGGTGLGLAIAKEVVEAHGGR 575
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-345 |
1.92e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 71.33 E-value: 1.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 257 LRMLLRNLVENAHRYSpqGSNIMIKLQEDG-GAVMAVEDEGPGIDESKCGELSKAFVRMDSRYG--GIGLGLSIVSRITQ 333
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGnRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGtsGTGLGLAIVQRISD 78
|
90
....*....|..
gi 1447699860 334 LHHGQFFLQNRQ 345
Cdd:cd16950 79 AHGGSLTLANRA 90
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
146-337 |
2.85e-15 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 76.99 E-value: 2.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 146 ERLFTADVAHELRTPLAGVRLHLELLAKtHHIDVAPLVAR--------LDQMMESVSQLLQLAR--AGQsfssgnyqhVK 215
Cdd:NF040691 271 QQRFVSDVSHELRTPLTTIRMAADVIHD-SRDDFDPATARsaellhteLDRFESLLSDLLEISRfdAGA---------AE 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 216 L------LEDVILPSYDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSpQGSNIMIKLQEDGGAV 289
Cdd:NF040691 341 LdvepvdLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAV 419
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1447699860 290 -MAVEDEGPGIDESKCGELSKAFVRMD-SR---YGGIGLGLSIVSRITQLHHG 337
Cdd:NF040691 420 aVTVRDHGVGLKPGEVALVFDRFWRADpARartTGGTGLGLAIALEDARLHGG 472
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
153-338 |
1.43e-14 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 74.11 E-value: 1.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 153 VAHELRTPLAGVRLHLELLAktHHIDVAPLVARLDQMMES-------VSQLLQLARAgqsfSSGNYQHV---KLLEDVIl 222
Cdd:COG3852 142 LAHEIRNPLTGIRGAAQLLE--RELPDDELREYTQLIIEEadrlnnlVDRLLSFSRP----RPPEREPVnlhEVLERVL- 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 223 psydelstmldqrqqTLLLPESAADITVQ-----------GDATLLRMLLRNLVENAHRYSPQGSNIMIK---------- 281
Cdd:COG3852 215 ---------------ELLRAEAPKNIRIVrdydpslpevlGDPDQLIQVLLNLVRNAAEAMPEGGTITIRtrverqvtlg 279
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1447699860 282 -LQEDGGAVMAVEDEGPGIDESkcgELSKAFvrmD----SRYGGIGLGLSIVSRITQLHHGQ 338
Cdd:COG3852 280 gLRPRLYVRIEVIDNGPGIPEE---ILDRIF---EpfftTKEKGTGLGLAIVQKIVEQHGGT 335
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
261-356 |
2.09e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 68.51 E-value: 2.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 261 LRNLVENAHRYSPQGSNIMIKlQEDGGAVMAVEDEGPGIDESKCGELSKAFVRMDSRY----GGIGLGLSIVSRITQLHH 336
Cdd:cd16949 5 LENVLRNALRYSPSKILLDIS-QDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARdresGGTGLGLAIAERAIEQHG 83
|
90 100
....*....|....*....|
gi 1447699860 337 GQFFLQNRqETSGTRAWVRL 356
Cdd:cd16949 84 GKIKASNR-KPGGLRVRIWL 102
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
124-337 |
3.19e-14 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 73.61 E-value: 3.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 124 EIEAVVSALNDlVSRLTST----LDNERL-----FTADVAHELRTPLAGVRLHLELLA-----KTHHIDVapLVARLDQM 189
Cdd:COG5805 257 SVKGILVILRD-ITEKKEAeelmARSEKLsiagqLAAGIAHEIRNPLTSIKGFLQLLQpgiedKEEYFDI--MLSELDRI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 190 MESVSQLLQLARAGQ-SFSSGNYQhvKLLEDVIlpsydelstMLDQRQQTL-----LLPESAADITVQGDATLLRMLLRN 263
Cdd:COG5805 334 ESIISEFLALAKPQAvNKEKENIN--ELIQDVV---------TLLETEAILhniqiRLELLDEDPFIYCDENQIKQVFIN 402
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1447699860 264 LVENAHRYSPQGSNIMIKLQEDGGAVM-AVEDEGPGIDESKCGELSKAFVRMDSRygGIGLGLSIVSRITQLHHG 337
Cdd:COG5805 403 LIKNAIEAMPNGGTITIHTEEEDNSVIiRVIDEGIGIPEERLKKLGEPFFTTKEK--GTGLGLMVSYKIIENHNG 475
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
257-357 |
3.70e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 67.90 E-value: 3.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 257 LRMLLRNLVENAHRYSPQGSnIMIKLQ---EDGGAVM---AVEDEGPGIDESKCGELSKAFVRMDS----RYGGIGLGLS 326
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGE-VTLRVSleeEEEDGVQlrfSVEDTGIGIPEEQQARLFEPFSQADSsttrKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 1447699860 327 IVSRITQLHHGQFFLQNRQEtSGTRAWVRLK 357
Cdd:cd16922 80 ISKKLVELMGGDISVESEPG-QGSTFTFTLP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
140-346 |
6.31e-14 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 73.15 E-value: 6.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 140 TSTLDNER------LFTAdVAHELRTPLAGVRLHLELL------AKTHHidvAPLVARLDQMMES----VSQLLQLARag 203
Cdd:PRK10490 653 QARLASEReqlrnaLLAA-LSHDLRTPLTVLFGQAEILtldlasEGSPH---ARQASEIRQQVLNttrlVNNLLDMAR-- 726
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 204 qsFSSGNYQHVK---LLEDVILPSYDELSTMLDQRQQTLLLPesaADIT-VQGDATLLRMLLRNLVENAHRYSPQGSNIM 279
Cdd:PRK10490 727 --IQSGGFNLRKewlTLEEVVGSALQMLEPGLSGHPINLSLP---EPLTlIHVDGPLFERVLINLLENAVKYAGAQAEIG 801
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 280 IKLQEDGGAV-MAVEDEGPGIDESKCGELSKAFVRMD--SRYGGIGLGLSIVSRITQLHHGQFFLQNRQE 346
Cdd:PRK10490 802 IDAHVEGERLqLDVWDNGPGIPPGQEQLIFDKFARGNkeSAIPGVGLGLAICRAIVEVHGGTIWAENRPE 871
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-353 |
1.00e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 66.72 E-value: 1.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 253 DATLLRMLLRNLVENAHRYSPQGSNIMIKLQ-EDGGAVMAVEDEGPGIDE---SKCGELSKAFVRMDSRYGGIGLGLSIV 328
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEaDTEGIELLVFDEGSGIPDyalNRVFERFYSLPRPHSGQKSTGLGLAFV 80
|
90 100
....*....|....*....|....*
gi 1447699860 329 SRITQLHHGQFFLQNRQETSGTRAW 353
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVLAFLT 105
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
153-338 |
5.01e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 69.59 E-value: 5.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 153 VAHELRTPLAGVRLHLELLAKTHHIDVAPLVARLD-----------QMMESVSQ-LLQLARAGQSFSSGNYQHV---KLL 217
Cdd:PRK09303 158 LAHDLRTPLTAASLALETLELGQIDEDTELKPALIeqlqdqarrqlEEIERLITdLLEVGRTRWEALRFNPQKLdlgSLC 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 218 EDVILpsydELSTMLDQRQQTLLlpesaADI-----TVQGDATLLRMLLRNLVENAHRYSPQGSNIMI--------KLQe 284
Cdd:PRK09303 238 QEVIL----ELEKRWLAKSLEIQ-----TDIpsdlpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLsmlhrttqKVQ- 307
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1447699860 285 dggavMAVEDEGPGIDESkcgELSKAF---VRM--DSRYGGIGLGLSIVSRITQLHHGQ 338
Cdd:PRK09303 308 -----VSICDTGPGIPEE---EQERIFedrVRLprDEGTEGYGIGLSVCRRIVRVHYGQ 358
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-337 |
5.34e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 64.79 E-value: 5.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 253 DATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDGGAVMAVEDEGPGIDESKCGELSKAFVRMDSR----YGGIGLGLSI 327
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAaQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnraSGGSGLGLAI 80
|
90
....*....|
gi 1447699860 328 VSRITQLHHG 337
Cdd:cd16946 81 CHNIALAHGG 90
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-335 |
3.77e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 62.22 E-value: 3.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 257 LRMLLRNLVENAHRYSPQGSNIMIKLQED-GGAVMAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRI 331
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEeSGARLSVEDTGPGIPPEHIPRLTERFYRVDiercRNTGGTGLGLAIVKHV 80
|
....
gi 1447699860 332 TQLH 335
Cdd:cd16952 81 MSRH 84
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
151-342 |
1.36e-11 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 65.82 E-value: 1.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 151 ADVAHELRTPLAGVRLHLELLAKThhidvaPLVAR----LDQMMESVSQLLQLARAGQSFS---SG----NYQHVKLLEd 219
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQNT------PLTAEqmdlADTARQCTLSLLAIINNLLDFSrieSGqmtlSLEETALLP- 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 220 vilpsydelstMLDQRQQTLLLPESAADITVQG------------DATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGG 287
Cdd:PRK15347 476 -----------LLDQAMLTIQGPAQSKSLTLRTfvgahvplylhlDSLRLRQILVNLLGNAVKFTETGGIRLRVKRHEQQ 544
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1447699860 288 AVMAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQ 342
Cdd:PRK15347 545 LCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLF 599
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
90-333 |
1.81e-11 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 65.70 E-value: 1.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 90 AVRRITRPLAELQKELEARTADnLTPIAIHSATLEIEAvvsalnDLVSRLTSTldnerlFTADVAHELRTPLAGVRLHLE 169
Cdd:PRK11466 401 NVHALNRHREQLAAQVKARTAE-LQELVIEHRQARAEA------EKASQAKSA------FLAAMSHEIRTPLYGILGTAQ 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 170 LLAKThhidvaPLVAR----LDQMMESVSQLLQLARAGQSFSS--GNYQHVKLLEDVILPS--YDELSTMLDQR--QQTL 239
Cdd:PRK11466 468 LLADN------PALNAqrddLRAITDSGESLLTILNDILDYSAieAGGKNVSVSDEPFEPRplLESTLQLMSGRvkGRPI 541
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 240 LLPESAADI---TVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAVMAVEDEGPGIDESKCGELSKAFVRMDS 316
Cdd:PRK11466 542 RLATDIADDlptALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSG 621
|
250
....*....|....*..
gi 1447699860 317 RYGGIGLGLSIVSRITQ 333
Cdd:PRK11466 622 KRGGTGLGLTISSRLAQ 638
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
261-337 |
2.14e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 60.14 E-value: 2.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 261 LRNLVENAHRYSPQGSNIMIKLQeDGGAVMAVEDEGPGIDESKCGELSKAFVRMDS----RYGGIGLGLSIVSRITQLHH 336
Cdd:cd16939 5 LDNLLRNALRYAHRTVRIALLVS-GGRLTLIVEDDGPGIPAAARERVFEPFVRLDPsrdrATGGFGLGLAIVHRVALWHG 83
|
.
gi 1447699860 337 G 337
Cdd:cd16939 84 G 84
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
146-344 |
3.68e-10 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 61.14 E-value: 3.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 146 ERL-----FTADVAHELRTPLAGVRLHLELLAK----THHIDVAPLVAR-LDQMMESVSQLLQLARAGQSfssgNYQHV- 214
Cdd:PRK11360 385 ERLaalgeLVAGVAHEIRNPLTAIRGYVQIWRQqtsdPPSQEYLSVVLReVDRLNKVIDQLLEFSRPRES----QWQPVs 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 215 ---------KLLEDVILPSYDELSTMLDQRqqtllLPesaadiTVQGDATLLRMLLRNLVENAHRYSPQGSNIMI--KLQ 283
Cdd:PRK11360 461 lnalveevlQLFQTAGVQARVDFETELDNE-----LP------PIWADPELLKQVLLNILINAVQAISARGKIRIrtWQY 529
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447699860 284 EDGGAVMAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNR 344
Cdd:PRK11360 530 SDGQVAVSIEDNGCGIDPELLKKIFDPF--FTTKAKGTGLGLALSQRIINAHGGDIEVESE 588
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-357 |
1.04e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 55.24 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 253 DATLLRMLLRNLVENAH-----RYSPQGS-NIMIKLQEDGGAVMAVEDEGPGIDESKCGELSKAFVrmDSRYGGIGLGLS 326
Cdd:cd16944 1 DTTQISQVLTNILKNAAeaiegRPSDVGEvRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYV--TTRPKGTGLGLA 78
|
90 100 110
....*....|....*....|....*....|.
gi 1447699860 327 IVSRITQLHHGQFFLQNRQETSgtrAWVRLK 357
Cdd:cd16944 79 IVKKIMEEHGGRISLSNREAGG---ACIRII 106
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
59-361 |
3.46e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.11 E-value: 3.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 59 RHIMREIREAVASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNLTPIAIHSaTLEIEAVVSALNDLVSR 138
Cdd:COG2972 146 SELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSG-NDEIGILARSFNEMVER 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 139 LTSTLDNERlftadvAHELRtplagvRLHLEL---------------------LAKTHHIDvaplvaRLDQMMESVSQLL 197
Cdd:COG2972 225 IKELIEEVY------ELELE------KKEAELkalqaqinphflfntlnsirwLAELEDPE------EAEEMLEALSKLL 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 198 QlaragQSFSSGNyQHVKLLEDV-ILPSY---------DELSTMLDqrqqtllLPESAADITVqgdatlLRMLLRNLVEN 267
Cdd:COG2972 287 R-----YSLSKGD-ELVTLEEELeLIKSYleiqklrfgDRLEVEIE-------IDEELLDLLI------PKLILQPLVEN 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 268 A--H--RYSPQGSNIMIKLQEDGGAVM-AVEDEGPGIDESKcgeLSKAFVRMDSRYGGIGLGLSIVSRITQLHHG---QF 339
Cdd:COG2972 348 AieHgiEPKEGGGTIRISIRKEGDRLViTVEDNGVGMPEEK---LEKLLEELSSKGEGRGIGLRNVRERLKLYYGeeyGL 424
|
330 340
....*....|....*....|..
gi 1447699860 340 FLQNRQETsGTRAWVRLKKDQN 361
Cdd:COG2972 425 EIESEPGE-GTTVTIRIPLEEE 445
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-344 |
4.59e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 54.06 E-value: 4.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 248 ITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAV-MAVEDEGPGIDESkcgELSKAFVRM-------DSRYG 319
Cdd:cd16947 12 IYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVyIDIWDKGKGISET---EKDHVFERLytledsrNSAKQ 88
|
90 100
....*....|....*....|....*
gi 1447699860 320 GIGLGLSIVSRITQLHHGQFFLQNR 344
Cdd:cd16947 89 GNGLGLTITKRLAESMGGSIYVNSK 113
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-351 |
4.70e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 53.48 E-value: 4.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 257 LRMLLRNLVENAHRYSPQG--SNIMIKLQEDGGA-VMAVEDEGPGIDESKCGELSKAFVRMDSR--YGGIGLGLSIVSRI 331
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEwTFYVRDNGIGIDPEYAEKVFGIFQRLHSReeYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|
gi 1447699860 332 TQLHHGQFFLQNrQETSGTR 351
Cdd:cd16921 81 IERHGGRIWLES-EPGEGTT 99
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-356 |
7.09e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 53.79 E-value: 7.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 226 DELSTMLD---QRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSpqGSNIMIKLQE-DGGAVMAVEDEGPGIDE 301
Cdd:cd16954 4 DSLCSALNkvyQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQtDGGLHLIVDDDGPGVPE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1447699860 302 SKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLqNRQETSGTRAWVRL 356
Cdd:cd16954 82 SQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSL-SDSPLGGARFEVVF 135
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-337 |
1.28e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 52.29 E-value: 1.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 253 DATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAV-MAVEDEGPGIDESkcgELSKAFVRMDSRYGG------IGLGL 325
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVvLSIKDFGIGIPEE---DLPRVFDKGFTGENGrnfqesTGMGL 78
|
90
....*....|...
gi 1447699860 326 SIVSRIT-QLHHG 337
Cdd:cd16948 79 YLVKKLCdKLGHK 91
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
253-337 |
4.09e-08 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 50.95 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 253 DATLLRMLLRNLVENAHRYSPQGSNIMIKLQ--EDGGAVMAVEDEGPGIDESKCGELSKAFVRMDS----RYGGIGLGLS 326
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEkfRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGsstrAHGGTGLGLS 80
|
90
....*....|.
gi 1447699860 327 IVSRITQLHHG 337
Cdd:cd16925 81 IVKEFVELHGG 91
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
147-201 |
8.51e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 48.75 E-value: 8.51e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1447699860 147 RLFTADVAHELRTPLAGVRLHLELLAKTHHID------VAPLVARLDQMMESVSQLLQLAR 201
Cdd:cd00082 5 GEFLANVSHELRTPLTAIRGALELLEEELLDDeeqreyLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-339 |
1.04e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 49.69 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 257 LRMLLRNLVENAHRYSPQGSNIMIK-LQEDGGAVMAVEDEGPGIDESKCGELSKAFVRMD-SRY-GGIGLGLSIVSRITQ 333
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITsFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDnSRNtEGAGLGLSIAKAIIE 80
|
....*.
gi 1447699860 334 LHHGQF 339
Cdd:cd16923 81 LHGGSA 86
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
147-204 |
2.01e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 47.59 E-value: 2.01e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1447699860 147 RLFTADVAHELRTPLAGVRLHLELLAKTHHIDVAP-----LVARLDQMMESVSQLLQLARAGQ 204
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQReyletILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
96-338 |
2.84e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 51.94 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 96 RP---LAELQKELEARTADNLTPiaihSATLEIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLELL- 171
Cdd:PRK10815 217 RPieaLAKQVRELEEGEREQLDP----NPPRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSLr 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 172 -AKTHHIDVAPLVarldqMMESVSQLLQ-----LARAgqSFSSGnyqHVKLLEDV--ILPSYDELSTMLD---QRQQTLL 240
Cdd:PRK10815 293 sGKQMSVEQAEPI-----MLEQISRISQqigyyLHRA--SMRSE---HNLLSRELhsVAPLLDNLTSALNkvyQRKGVNI 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 241 LPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIkLQEDGGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYGG 320
Cdd:PRK10815 363 TLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISA-RQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPG 441
|
250
....*....|....*...
gi 1447699860 321 IGLGLSIVSRITQLHHGQ 338
Cdd:PRK10815 442 QGLGLSVAREITEQYEGK 459
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
147-204 |
4.49e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 46.79 E-value: 4.49e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1447699860 147 RLFTADVAHELRTPLAGVRLHLELLAKTHHID-----VAPLVARLDQMMESVSQLLQLARAGQ 204
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEeqreyLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-356 |
5.51e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 47.57 E-value: 5.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 257 LRMLLRNLVENAHRYSPQgSNIMIKLQEDGGA---VMAVEDEGPGIDESKcgeLSKAFVRMDSR------YG-GIGLGLS 326
Cdd:cd16953 1 LGQVLRNLIGNAISFSPP-DTGRITVSAMPTGkmvTISVEDEGPGIPQEK---LESIFDRFYTErpaneaFGqHSGLGLS 76
|
90 100 110
....*....|....*....|....*....|...
gi 1447699860 327 IVSRITQLHHGQFFLQNRQE---TSGTRAWVRL 356
Cdd:cd16953 77 ISRQIIEAHGGISVAENHNQpgqVIGARFTVQL 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
260-338 |
6.36e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 47.39 E-value: 6.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 260 LLRNLVENAHRYSPQGSNIMIKLQEDGGAVMA--VEDEGPGIDESKCGELSKAFVrmDSRYGGIGLGLSIVSRITQLHHG 337
Cdd:cd16920 8 LVRNGIEAMSEGGCERRELTIRTSPADDRAVTisVKDTGPGIAEEVAGQLFDPFY--TTKSEGLGMGLSICRSIIEAHGG 85
|
.
gi 1447699860 338 Q 338
Cdd:cd16920 86 R 86
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
250-340 |
1.06e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 50.62 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 250 VQGDATLLRMLLRNLVENAHRYSPQGsNIMIKLQEDGGAVMAVE------DEGPGIDESKCGELSKAFVRMDS----RYG 319
Cdd:PRK11107 402 VIGDPLRLQQIITNLVGNAIKFTESG-NIDILVELRALSNTKVQlevqirDTGIGISERQQSQLFQAFRQADAsisrRHG 480
|
90 100 110
....*....|....*....|....*....|..
gi 1447699860 320 GIGLGLSIVSRI-----------TQLHHGQFF 340
Cdd:PRK11107 481 GTGLGLVITQKLvnemggdisfhSQPNRGSTF 512
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-357 |
2.91e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 45.53 E-value: 2.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 253 DATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAV-MAVEDEGPGIDESKCGELSKAFVRMD-SRYGG--IGLGLSIV 328
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLyFEIWDNGHGFSEQDLKKALELFYRDDtSRRSGghYGMGLYIA 80
|
90 100
....*....|....*....|....*....
gi 1447699860 329 SRITQLHHGQFFLQNRQETSgtrAWVRLK 357
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGG---AEVTVK 106
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
153-341 |
5.77e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 48.14 E-value: 5.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 153 VAHELRTPLAGVRLHLELLAK-THHIDVAPLVARLDQMMESVSQLLQLARAGQSFS--SGNYQHVKLLEDVILPSYDELS 229
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKaLEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSrkSDTPLQPVDLRQVIEQAWELVE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 230 TMLDQRQQTLLLPEsaaDITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQE-DGGAVMAVEDEGPGIDESKcgELS 308
Cdd:COG4192 520 SRAKPQQITLHIPD---DLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSnAENLRVAISDNGNGWPLVD--KLF 594
|
170 180 190
....*....|....*....|....*....|...
gi 1447699860 309 KAFVrmDSRYGGIGLGLSIVSRITQLHHGQFFL 341
Cdd:COG4192 595 TPFT--TTKEVGLGLGLSICRSIMQQFGGDLYL 625
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
149-338 |
2.65e-05 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 46.09 E-value: 2.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 149 FTADVAHELRTPLAG-VRLHLELL-----------AKTHHIDVAPL------VARLDQMMEsvsQLLQLARAGQSFSSgn 210
Cdd:PRK11091 286 FISTISHELRTPLNGiVGLSRILLdteltaeqrkyLKTIHVSAITLgnifndIIDMDKMER---RKLQLDNQPIDFTD-- 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 211 yqhvkLLEDVilpsyDELSTMLDQrQQTLLL---PESAADITVQGDATLLRMLLRNLVENAHRYSPQGSnIMIKLQEDGG 287
Cdd:PRK11091 361 -----FLADL-----ENLSGLQAE-QKGLRFdlePLLPLPHKVITDGTRLRQILWNLISNAVKFTQQGG-VTVRVRYEEG 428
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1447699860 288 AV--MAVEDEGPGIDESkcgELSKAFVrM-----DSRYG----GIGLGLSIVSRITQLHHGQ 338
Cdd:PRK11091 429 DMltFEVEDSGIGIPED---ELDKIFA-MyyqvkDSHGGkpatGTGIGLAVSKRLAQAMGGD 486
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
147-338 |
2.85e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 45.46 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 147 RLFTADVAHELRTPLAGVRLHLELLAK----------THHI-----DVAPLVARL-------DQMMESVSQLLQLARAGQ 204
Cdd:PRK11073 131 RDLVRGLAHEIKNPLGGLRGAAQLLSKalpdpalteyTKVIieqadRLRNLVDRLlgpqrpgTHVTESIHKVAERVVQLV 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 205 SFSSGnyQHVKLLEDVIlPSYDELSTMLDQRQQTLL-LPESAADITVQGDATllrMLLRNlvENAHRYSPQGSNIMIklq 283
Cdd:PRK11073 211 SLELP--DNVRLIRDYD-PSLPELAHDPDQIEQVLLnIVRNALQALGPEGGT---ITLRT--RTAFQLTLHGERYRL--- 279
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1447699860 284 edgGAVMAVEDEGPGIDESKCGELskaFVRMDS-RYGGIGLGLSIVSRITQLHHGQ 338
Cdd:PRK11073 280 ---AARIDIEDNGPGIPPHLQDTL---FYPMVSgREGGTGLGLSIARNLIDQHSGK 329
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-337 |
2.90e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 42.79 E-value: 2.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 256 LLRMLLRNLVENAHRYSPQGSNIMIKL-QEDGGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQL 334
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTwAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQK 82
|
...
gi 1447699860 335 HHG 337
Cdd:cd16943 83 HGG 85
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
149-343 |
3.86e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 45.88 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 149 FTADVAHELRTPLAGVRLHLEL-----LAKTHHIDVAPLVARLDQ-MMESVSQLLQLARagqsFSSGNYQhvklledvIL 222
Cdd:PRK09959 715 FLATMSHEIRTPISSIMGFLELlsgsgLSKEQRVEAISLAYATGQsLLGLIGEILDVDK----IESGNYQ--------LQ 782
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 223 PSYDELSTMLDQRQQTLLLPESAADIT------------VQGDATLLRMLLRNLVENAHRYSPQGS-NIMIKLQ--EDGG 287
Cdd:PRK09959 783 PQWVDIPTLVQNTCHSFGAIAASKSIAlscsstfpdhylVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGhiDDNH 862
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 288 AV--MAVEDEGPGIDESKCGELSKAFVRMDS--RYGGIGLGLSIVSRITQLHHGQFFLQN 343
Cdd:PRK09959 863 AVikMTIMDSGSGLSQEEQQQLFKRYSQTSAgrQQTGSGLGLMICKELIKNMQGDLSLES 922
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
260-351 |
5.20e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 41.67 E-value: 5.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 260 LLRNLVENAHR--YSPQGSNIMIKLQ-EDGGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHH 336
Cdd:cd16976 4 VLMNLLQNALDamGKVENPRIRIAARrLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEHG 83
|
90
....*....|....*
gi 1447699860 337 GQFFLQNrQETSGTR 351
Cdd:cd16976 84 GRLSVAN-EEGAGAR 97
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
151-338 |
3.40e-04 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 42.47 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 151 ADVAHELRTPLAGVRLHLELLAK------THHIDVAPLVARLDQMMESVSQLLQLARAgqsfSSGNYQHVKlLEDVILPS 224
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAErapaggEAHQLAQVMAKEADRLNRVVSELLELVKP----THLALQAVD-LNDLINHS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 225 YDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAV-MAVEDEGPGIDESk 303
Cdd:PRK10364 317 LQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVkISVTDSGKGIAAD- 395
|
170 180 190
....*....|....*....|....*....|....*.
gi 1447699860 304 cgELSKAFV-RMDSRYGGIGLGLSIVSRITQLHHGQ 338
Cdd:PRK10364 396 --QLEAIFTpYFTTKAEGTGLGLAVVHNIVEQHGGT 429
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
253-359 |
4.77e-04 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 41.76 E-value: 4.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 253 DATLLRMLLRNLVENAHRYSPQGSN----IMIKLQEDGGAVM-AVEDEGPGIDESkcgELSKAFVRMDS--RYGGIGLGL 325
Cdd:COG3290 278 SDTDLVTILGNLLDNAIEAVEKLPEeerrVELSIRDDGDELViEVEDSGPGIPEE---LLEKIFERGFStkLGEGRGLGL 354
|
90 100 110
....*....|....*....|....*....|....
gi 1447699860 326 SIVSRITQLHHGQFFLQNRQETsGTRAWVRLKKD 359
Cdd:COG3290 355 ALVKQIVEKYGGTIEVESEEGE-GTVFTVRLPKE 387
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
148-327 |
5.35e-04 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 41.88 E-value: 5.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 148 LFTADVAHELRTPLAGVRLHLELLaKTHhiDVAPLVARLDQMMESVSQLL----------------QLARAGQSFS---- 207
Cdd:PRK10841 449 MFLATVSHELRTPLYGIIGNLDLL-QTK--ELPKGVDRLVTAMNNSSSLLlkiisdildfskieseQLKIEPREFSprev 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 208 ----SGNYqhvklledviLPsydelstMLDQRQQTLL-LPESAADITVQGDATLLRMLLRNLVENAHRYSPQGsNIMIKL 282
Cdd:PRK10841 526 inhiTANY----------LP-------LVVKKRLGLYcFIEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTG-CIVLHV 587
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1447699860 283 QEDGG-AVMAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSI 327
Cdd:PRK10841 588 RVDGDyLSFRVRDTGVGIPAKEVVRLFDPFFQVgtgvQRNFQGTGLGLAI 637
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
263-356 |
6.94e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 38.81 E-value: 6.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 263 NLVENAH----RYSPQGSNIMIKLQEDGGAV-MAVEDEGPGIDESKcgeLSKAFVRMDSR--YGGIGLGLSIVSRITQLH 335
Cdd:cd16915 7 NLIDNALdalaATGAPNKQVEVFLRDEGDDLvIEVRDTGPGIAPEL---RDKVFERGVSTkgQGERGIGLALVRQSVERL 83
|
90 100
....*....|....*....|.
gi 1447699860 336 HGQFFLQNrQETSGTRAWVRL 356
Cdd:cd16915 84 GGSITVES-EPGGGTTFSIRI 103
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
161-356 |
1.12e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.99 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 161 LAGVRLHLELLAKTHHIDVAPLVARLDQMMESVSQLLQLARAgqsfSSGNYQHVKLLEDVILPSYDELSTMLDQRQQ--- 237
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRR----LVRGLRPPALDDLGLAAALEELAERLLRAAGirv 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 238 TLLLPESAADITVQGDATLLRMLlRNLVENAHRYSpQGSNIMIKLQEDGGAV-MAVEDEGPGIDESKCGElskafvrmds 316
Cdd:COG4585 145 ELDVDGDPDRLPPEVELALYRIV-QEALTNALKHA-GATRVTVTLEVDDGELtLTVRDDGVGFDPEAAPG---------- 212
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1447699860 317 ryGGIGLgLSIVSRItQLHHGQFFLQNRQEtSGTRAWVRL 356
Cdd:COG4585 213 --GGLGL-RGMRERA-EALGGTLTIGSAPG-GGTRVRATL 247
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
292-337 |
1.52e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 37.77 E-value: 1.52e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1447699860 292 VEDEGPGIDESKCGELSKAFVrmDSRYGGIGLGLSIVSRITQLHHG 337
Cdd:cd16918 48 VIDNGPGIPPDLQDTIFYPMV--SGRENGTGLGLAIAQNIVSQHGG 91
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
92-144 |
7.60e-03 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 34.15 E-value: 7.60e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1447699860 92 RRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTLD 144
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
259-302 |
8.01e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 35.51 E-value: 8.01e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1447699860 259 MLLRNLVENA--HRYSPQGS----NIMIKLQEDGGAVMAVEDEGPGIDES 302
Cdd:cd16955 4 LMIQPLVENAivHGIQEKKGkgvvKISVKKQLKNRLHIAVEDNGIGISPK 53
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
259-361 |
9.50e-03 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 37.54 E-value: 9.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447699860 259 MLLRNLVENA--H--RYSPQGSNIMIKLQEDGG-AVMAVEDEGPGIDESKcgelskafvrmDSRYGGIGLGlSIVSRITQ 333
Cdd:COG3275 256 LLLQPLVENAikHgiSSKEGGGTISISIEVEGDrLVIEVENNGVGIQPKK-----------KKKGSGIGLK-NVRERLEL 323
|
90 100
....*....|....*....|....*....
gi 1447699860 334 LHHGQFFLQ-NRQETSGTRAWVRLKKDQN 361
Cdd:COG3275 324 LYGDKYSLEiESTDGGGTKVTLKIPLKKE 352
|
|
| |
