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Conserved domains on  [gi|1134749503|ref|NP_313211|]
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OapA family protein [Escherichia coli O157:H7 str. Sakai]

Protein Classification

OapA family protein( domain architecture ID 11459647)

opacity-associated protein OapA family protein similar to Escherichia coli cell division protein YtfB whose function is related to the generation of a transient cell wall structure

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 22-212 1.90e-44

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 153.28  E-value: 1.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749503  22 RFMDPLPPMHRRGIIIAAIVLVVGFLLPSDDTPNAPVvtreaqldiqSQSQPPTEEQLRAQLvtpqnyPDQVAPVAPEPI 101
Cdd:COG3061     2 GRMNPLPRKHRRLLGLLSALLLLALLLPSPDASASRV----------SQPLVPLALTAEADA------PAAAAPAAPAAP 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749503 102 QEgqpeeqpkttqtqpfqpdsgidnQWRSYRVEPGKTMAQLFRDHGLPATDVYAMAQVEGAGKPLSNLQNGQMVKIRQNA 181
Cdd:COG3061    66 EG-----------------------EWQEYTVQSGDTLSQIFRRLGLSASDLYALLAAEGDAKPLSRLKPGQELRFQLDA 122

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1134749503 182 SGVVTGLTIDTGNNQQVLFTRQPDGsFIRAR 212
Cdd:COG3061   123 DGQLQALRYEVSRLETLLFTRQGDG-FQRKR 152
 
Name Accession Description Interval E-value
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 22-212 1.90e-44

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 153.28  E-value: 1.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749503  22 RFMDPLPPMHRRGIIIAAIVLVVGFLLPSDDTPNAPVvtreaqldiqSQSQPPTEEQLRAQLvtpqnyPDQVAPVAPEPI 101
Cdd:COG3061     2 GRMNPLPRKHRRLLGLLSALLLLALLLPSPDASASRV----------SQPLVPLALTAEADA------PAAAAPAAPAAP 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749503 102 QEgqpeeqpkttqtqpfqpdsgidnQWRSYRVEPGKTMAQLFRDHGLPATDVYAMAQVEGAGKPLSNLQNGQMVKIRQNA 181
Cdd:COG3061    66 EG-----------------------EWQEYTVQSGDTLSQIFRRLGLSASDLYALLAAEGDAKPLSRLKPGQELRFQLDA 122

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1134749503 182 SGVVTGLTIDTGNNQQVLFTRQPDGsFIRAR 212
Cdd:COG3061   123 DGQLQALRYEVSRLETLLFTRQGDG-FQRKR 152
OapA pfam04225
Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the ...
 127-212 9.45e-44

Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. The OapA domain has been shown to bind to peptidoglycan in the E. coli protein YtfB. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links. The OapA domain is distantly related to pfam01476.


Pssm-ID: 427799 [Multi-domain]  Cd Length: 85  Bit Score: 141.33  E-value: 9.45e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749503 127 QWRSYRVEPGKTMAQLFRDHGLPATDVYAMAQVEGAGKPLSNLQNGQMVKIRQNASGVVTGLTIDTGnNQQVLFTRQPDG 206
Cdd:pfam04225   1 NWKTYTVPKGDTLAQLFRDNNLPISDVNAMAKVEGADKPLSNIKSGQLVRIKLNAQGRVDELQIENG-AKSVMFFRQSDG 79


                  ....*.
gi 1134749503 207 SFIRAR 212
Cdd:pfam04225  80 SFGRKK 85
 
Name Accession Description Interval E-value
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 22-212 1.90e-44

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 153.28  E-value: 1.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749503  22 RFMDPLPPMHRRGIIIAAIVLVVGFLLPSDDTPNAPVvtreaqldiqSQSQPPTEEQLRAQLvtpqnyPDQVAPVAPEPI 101
Cdd:COG3061     2 GRMNPLPRKHRRLLGLLSALLLLALLLPSPDASASRV----------SQPLVPLALTAEADA------PAAAAPAAPAAP 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749503 102 QEgqpeeqpkttqtqpfqpdsgidnQWRSYRVEPGKTMAQLFRDHGLPATDVYAMAQVEGAGKPLSNLQNGQMVKIRQNA 181
Cdd:COG3061    66 EG-----------------------EWQEYTVQSGDTLSQIFRRLGLSASDLYALLAAEGDAKPLSRLKPGQELRFQLDA 122

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1134749503 182 SGVVTGLTIDTGNNQQVLFTRQPDGsFIRAR 212
Cdd:COG3061   123 DGQLQALRYEVSRLETLLFTRQGDG-FQRKR 152
OapA pfam04225
Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the ...
 127-212 9.45e-44

Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. The OapA domain has been shown to bind to peptidoglycan in the E. coli protein YtfB. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links. The OapA domain is distantly related to pfam01476.


Pssm-ID: 427799 [Multi-domain]  Cd Length: 85  Bit Score: 141.33  E-value: 9.45e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134749503 127 QWRSYRVEPGKTMAQLFRDHGLPATDVYAMAQVEGAGKPLSNLQNGQMVKIRQNASGVVTGLTIDTGnNQQVLFTRQPDG 206
Cdd:pfam04225   1 NWKTYTVPKGDTLAQLFRDNNLPISDVNAMAKVEGADKPLSNIKSGQLVRIKLNAQGRVDELQIENG-AKSVMFFRQSDG 79


                  ....*.
gi 1134749503 207 SFIRAR 212
Cdd:pfam04225  80 SFGRKK 85
OapA_N pfam08525
Opacity-associated protein A N-terminal motif; This family includes the Haemophilus influenzae ...
 23-49 2.17e-06

Opacity-associated protein A N-terminal motif; This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. This motif occurs at the N-terminus of these proteins. It contains a conserved histidine followed by a run of hydrophobic residues.


Pssm-ID: 430054  Cd Length: 27  Bit Score: 42.69  E-value: 2.17e-06
                          10        20
                  ....*....|....*....|....*..
gi 1134749503  23 FMDPLPPMHRRGIIIAAIVLVVGFLLP 49
Cdd:pfam08525   1 LFKPLPKLHRRLLLALSLVVLILLLWP 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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