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Conserved domains on  [gi|47519929|ref|NP_387504|]
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contactin-associated protein-like 3 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 2.16e-34

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 129.01  E-value: 2.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929   54 HGPGFSRLNRrdgAGGWTPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSDWVTSYLLMFSDGGRNWKQYRREESIWG 131
Cdd:cd00057   24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 47519929  132 FPGNTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYG 176
Cdd:cd00057  101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 794-938 2.66e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.44  E-value: 2.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929  794 SASFnTETSYLHFPAFHGELT-ADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTeVTFSFDVGNGPceVTVQSPTP 870
Cdd:cd00110    1 GVSF-SGSSYVRLPTLPAPRTrLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGR-LVLRYDLGSGS--LVLSSKTP 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47519929  871 FNDNQWHHVRAERNVKGASLQVDQLPQkMQPAPADGHVRLQLNSQLFIGGT--------ATRQRGFLGCIRSLQLN 938
Cdd:cd00110   77 LNDGQWHSVSVERNGRSVTLSVDGERV-VESGSPGGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 6.70e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.04  E-value: 6.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    212 FKAMQSNGILLHREGQHGNHITLELIKGKLVFFLNSGNAKlpstiaPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKH 291
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGP------ESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 47519929    292 THHFQAK-GDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 398-522 3.18e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 99.03  E-value: 3.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    398 FRTWNRAGHLLFGElRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQ- 476
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSs 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 47519929    477 --PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITIGDK 522
Cdd:pfam02210   80 lpPGESLLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1046-1174 1.74e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.85  E-value: 1.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929   1046 FRTTRTPSLLLYVSSFYEEYLSVILaNNGSLQIRYKLDRHQNPDAFTfdFKNMADGQLHQVKINREEAVVMVEVNQSTKK 1125
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSS--GKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 47519929   1126 QVILSSGTE-FNAVKSLILGKVLEaagADPDTRRAATSGFTGCLSAVRFG 1174
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGGLPP---LLLLPALPVRAGFVGCIRDVRVN 124
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 591-633 1.05e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 52.18  E-value: 1.05e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 47519929   591 SCEA--HKHRGNPSGLYYIDADGSGPLGPFLVYCNMTAD-AAWTVV 633
Cdd:NF040941    1 SCWEilQAGPSAPSGVYWIDPDGMGGLAPFQVYCDMTTDgGGWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-582 2.16e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47519929    551 CLPSYCEHGGECSQSWDTFSCDCLgTGYTGET 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 2.16e-34

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 129.01  E-value: 2.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929   54 HGPGFSRLNRrdgAGGWTPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSDWVTSYLLMFSDGGRNWKQYRREESIWG 131
Cdd:cd00057   24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 47519929  132 FPGNTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYG 176
Cdd:cd00057  101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 794-938 2.66e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.44  E-value: 2.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929  794 SASFnTETSYLHFPAFHGELT-ADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTeVTFSFDVGNGPceVTVQSPTP 870
Cdd:cd00110    1 GVSF-SGSSYVRLPTLPAPRTrLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGR-LVLRYDLGSGS--LVLSSKTP 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47519929  871 FNDNQWHHVRAERNVKGASLQVDQLPQkMQPAPADGHVRLQLNSQLFIGGT--------ATRQRGFLGCIRSLQLN 938
Cdd:cd00110   77 LNDGQWHSVSVERNGRSVTLSVDGERV-VESGSPGGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-174 9.62e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 112.16  E-value: 9.62e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929     54 HGPGFSRLNRRDG--AGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSDWVTSYLLMFSDGGRNWKQYRREEsiw 130
Cdd:pfam00754    8 YSGEGPAAAALDGdpNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDEK--- 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 47519929    131 gFPGNTNADSVVHYRLQPPFEARFLRFLPLAWNPRGRIGMRIEV 174
Cdd:pfam00754   85 -IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-177 2.81e-28

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 111.06  E-value: 2.81e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929      55 GPGFSRLNRrDGAGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYlLMFSDGGRNWKQYRREESIwGFPG 134
Cdd:smart00231   22 AAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPG 98

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 47519929     135 NTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYGC 177
Cdd:smart00231   99 NSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
LamG smart00282
Laminin G domain;
816-940 3.55e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.55e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929     816 DVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTeVTFSFDVGNGPCEVTVQsPTPFNDNQWHHVRAERNVKGASLQVD 893
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGR-LVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47519929     894 QLPQKMQPAPAdGHVRLQLNSQLFIGGT--------ATRQRGFLGCIRSLQLNGV 940
Cdd:smart00282   79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 821-940 4.79e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.12  E-value: 4.79e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    821 FKTTVSSGVFMEN-LGITDFIRIELRAPTeVTFSFDVGNGPcEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKM 899
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGR-LVLRYDLGSGP-ESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 47519929    900 QPAPADGHVrLQLNSQLFIGG--------TATRQRGFLGCIRSLQLNGV 940
Cdd:pfam02210   79 SLPPGESLL-LNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 6.70e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.04  E-value: 6.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    212 FKAMQSNGILLHREGQHGNHITLELIKGKLVFFLNSGNAKlpstiaPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKH 291
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGP------ESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 47519929    292 THHFQAK-GDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 183-339 1.09e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.34  E-value: 1.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929  183 VVYFDGQSAllYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQ-HGNHITLELIKGKLVFFLNSGNAklpstiaPVTL 261
Cdd:cd00110    1 GVSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSG-------SLVL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929  262 TLGSLLDDQHWHSVLIELLDTQVNFTVDKHTH-HFQAKGDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYN 339
Cdd:cd00110   72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPvSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 398-522 3.18e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 99.03  E-value: 3.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    398 FRTWNRAGHLLFGElRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQ- 476
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSs 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 47519929    477 --PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITIGDK 522
Cdd:pfam02210   80 lpPGESLLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 371-519 1.28e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.26  E-value: 1.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929  371 PVTFlSSRSYLALPGNSGE-DKVSVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAGLN 449
Cdd:cd00110    1 GVSF-SGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47519929  450 DGQWHSVSFSAKWSHMNVVVDDDTAVQ---PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITI 519
Cdd:cd00110   79 DGQWHSVSVERNGRSVTLSVDGERVVEsgsPGGSALLNLDGPLYLGG-LPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
208-341 8.38e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.40  E-value: 8.38e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929     208 ISLKFKAMQSNGILLH-REGQHGNHITLELIKGKLVFFLNSGNaklpstiAPVTLTLGSL-LDDQHWHSVLIELLDTQVN 285
Cdd:smart00282    2 ISFSFRTTSPNGLLLYaGSKGGGDYLALELRDGRLVLRYDLGS-------GPARLTSDPTpLNDGQWHRVAVERNGRSVT 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 47519929     286 FTVDKHTH-HFQAKGDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:smart00282   75 LSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
393-522 2.04e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.47  E-value: 2.04e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929     393 SVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAG-LNDGQWHSVSFSAKWSHMNVVVDD 471
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 47519929     472 DTAVQ---PLVAVLIDSGDTYYFGGCLDNSSGSGcKSPLGGFQGCLRLITIGDK 522
Cdd:smart00282   80 GNRVSgesPGGLTILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1046-1174 1.74e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.85  E-value: 1.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929   1046 FRTTRTPSLLLYVSSFYEEYLSVILaNNGSLQIRYKLDRHQNPDAFTfdFKNMADGQLHQVKINREEAVVMVEVNQSTKK 1125
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSS--GKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 47519929   1126 QVILSSGTE-FNAVKSLILGKVLEaagADPDTRRAATSGFTGCLSAVRFG 1174
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGGLPP---LLLLPALPVRAGFVGCIRDVRVN 124
LamG smart00282
Laminin G domain;
1042-1173 3.33e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.05  E-value: 3.33e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    1042 ITLSFRTTRTPSLLLYVSSFYE-EYLSVILaNNGSLQIRYKLDrhQNPDAFTFDFKNMADGQLHQVKINREEAVVMVEVN 1120
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 47519929    1121 QSTK-KQVILSSGTEFNAVKSLILGKVLEAAGADPDTrraATSGFTGCLSAVRF 1173
Cdd:smart00282   79 GGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1042-1173 3.73e-12

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 65.52  E-value: 3.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929 1042 ITLSFRTTRTPSLLLYVSSFYE-EYLSVILaNNGSLQIRYKLdrhqNPDAFTFDFKN-MADGQLHQVKINREEAVVMVEV 1119
Cdd:cd00110   24 ISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDL----GSGSLVLSSKTpLNDGQWHSVSVERNGRSVTLSV 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 47519929 1120 NQSTKKQVILSSGTEF-NAVKSLILGKVLEAAGADPDTRRAatsGFTGCLSAVRF 1173
Cdd:cd00110   99 DGERVVESGSPGGSALlNLDGPLYLGGLPEDLKSPGLPVSP---GFVGCIRDLKV 150
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 591-633 1.05e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 52.18  E-value: 1.05e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 47519929   591 SCEA--HKHRGNPSGLYYIDADGSGPLGPFLVYCNMTAD-AAWTVV 633
Cdd:NF040941    1 SCWEilQAGPSAPSGVYWIDPDGMGGLAPFQVYCDMTTDgGGWTLV 46
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 590-635 3.09e-05

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 46.46  E-value: 3.09e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 47519929  590 QSC-EAHKHRGNPSGLYYIDADGSGPlgPFLVYCNM-TADAAWTVVQH 635
Cdd:cd00087    4 RDCsEVLQRGGRTSGVYTIQPPGSNE--PFQVYCDMdTDGGGWTVIQR 49
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 593-635 1.18e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 44.96  E-value: 1.18e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47519929     593 EAHKHRGNPSGLYYIDADGSGPlgPFLVYCNMTADA-AWTVVQH 635
Cdd:smart00186    7 DVLQNGGKTSGLYTIYPDGSSR--PLKVYCDMETDGgGWTVIQR 48
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-582 2.16e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47519929    551 CLPSYCEHGGECSQSWDTFSCDCLgTGYTGET 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 549-583 1.71e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.71e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 47519929  549 DRCL-PSYCEHGGECSQSWDTFSCDCLgTGYTGETC 583
Cdd:cd00054    3 DECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 2.16e-34

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 129.01  E-value: 2.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929   54 HGPGFSRLNRrdgAGGWTPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSDWVTSYLLMFSDGGRNWKQYRREESIWG 131
Cdd:cd00057   24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 47519929  132 FPGNTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYG 176
Cdd:cd00057  101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 794-938 2.66e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.44  E-value: 2.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929  794 SASFnTETSYLHFPAFHGELT-ADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTeVTFSFDVGNGPceVTVQSPTP 870
Cdd:cd00110    1 GVSF-SGSSYVRLPTLPAPRTrLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGR-LVLRYDLGSGS--LVLSSKTP 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47519929  871 FNDNQWHHVRAERNVKGASLQVDQLPQkMQPAPADGHVRLQLNSQLFIGGT--------ATRQRGFLGCIRSLQLN 938
Cdd:cd00110   77 LNDGQWHSVSVERNGRSVTLSVDGERV-VESGSPGGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-174 9.62e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 112.16  E-value: 9.62e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929     54 HGPGFSRLNRRDG--AGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSDWVTSYLLMFSDGGRNWKQYRREEsiw 130
Cdd:pfam00754    8 YSGEGPAAAALDGdpNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDEK--- 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 47519929    131 gFPGNTNADSVVHYRLQPPFEARFLRFLPLAWNPRGRIGMRIEV 174
Cdd:pfam00754   85 -IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-177 2.81e-28

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 111.06  E-value: 2.81e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929      55 GPGFSRLNRrDGAGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYlLMFSDGGRNWKQYRREESIwGFPG 134
Cdd:smart00231   22 AAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPG 98

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 47519929     135 NTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYGC 177
Cdd:smart00231   99 NSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
LamG smart00282
Laminin G domain;
816-940 3.55e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.55e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929     816 DVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTeVTFSFDVGNGPCEVTVQsPTPFNDNQWHHVRAERNVKGASLQVD 893
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGR-LVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47519929     894 QLPQKMQPAPAdGHVRLQLNSQLFIGGT--------ATRQRGFLGCIRSLQLNGV 940
Cdd:smart00282   79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 821-940 4.79e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.12  E-value: 4.79e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    821 FKTTVSSGVFMEN-LGITDFIRIELRAPTeVTFSFDVGNGPcEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKM 899
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGR-LVLRYDLGSGP-ESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 47519929    900 QPAPADGHVrLQLNSQLFIGG--------TATRQRGFLGCIRSLQLNGV 940
Cdd:pfam02210   79 SLPPGESLL-LNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 6.70e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.04  E-value: 6.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    212 FKAMQSNGILLHREGQHGNHITLELIKGKLVFFLNSGNAKlpstiaPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKH 291
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGP------ESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 47519929    292 THHFQAK-GDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 183-339 1.09e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.34  E-value: 1.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929  183 VVYFDGQSAllYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQ-HGNHITLELIKGKLVFFLNSGNAklpstiaPVTL 261
Cdd:cd00110    1 GVSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSG-------SLVL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929  262 TLGSLLDDQHWHSVLIELLDTQVNFTVDKHTH-HFQAKGDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYN 339
Cdd:cd00110   72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPvSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 398-522 3.18e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 99.03  E-value: 3.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    398 FRTWNRAGHLLFGElRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQ- 476
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSs 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 47519929    477 --PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITIGDK 522
Cdd:pfam02210   80 lpPGESLLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 371-519 1.28e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.26  E-value: 1.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929  371 PVTFlSSRSYLALPGNSGE-DKVSVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAGLN 449
Cdd:cd00110    1 GVSF-SGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47519929  450 DGQWHSVSFSAKWSHMNVVVDDDTAVQ---PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITI 519
Cdd:cd00110   79 DGQWHSVSVERNGRSVTLSVDGERVVEsgsPGGSALLNLDGPLYLGG-LPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
208-341 8.38e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.40  E-value: 8.38e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929     208 ISLKFKAMQSNGILLH-REGQHGNHITLELIKGKLVFFLNSGNaklpstiAPVTLTLGSL-LDDQHWHSVLIELLDTQVN 285
Cdd:smart00282    2 ISFSFRTTSPNGLLLYaGSKGGGDYLALELRDGRLVLRYDLGS-------GPARLTSDPTpLNDGQWHRVAVERNGRSVT 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 47519929     286 FTVDKHTH-HFQAKGDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:smart00282   75 LSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
821-943 1.70e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 85.83  E-value: 1.70e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    821 FKTTVSSGVFMENLGIT--DFIRIELRApTEVTFSFDVGNGPceVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQL--P 896
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRD-GRLEVSYDLGSGA--AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEarP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 47519929    897 QKMQPAPADGHvrLQLNSQLFIGGT---------ATRQRGFLGCIRSLQLNGVALD 943
Cdd:pfam00054   78 TGESPLGATTD--LDVDGPLYVGGLpslgvkkrrLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
393-522 2.04e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.47  E-value: 2.04e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929     393 SVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAG-LNDGQWHSVSFSAKWSHMNVVVDD 471
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 47519929     472 DTAVQ---PLVAVLIDSGDTYYFGGCLDNSSGSGcKSPLGGFQGCLRLITIGDK 522
Cdd:smart00282   80 GNRVSgesPGGLTILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1046-1174 1.74e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.85  E-value: 1.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929   1046 FRTTRTPSLLLYVSSFYEEYLSVILaNNGSLQIRYKLDRHQNPDAFTfdFKNMADGQLHQVKINREEAVVMVEVNQSTKK 1125
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSS--GKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 47519929   1126 QVILSSGTE-FNAVKSLILGKVLEaagADPDTRRAATSGFTGCLSAVRFG 1174
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGGLPP---LLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_1 pfam00054
Laminin G domain;
398-525 5.02e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 70.04  E-value: 5.02e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    398 FRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAV-- 475
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVS-YDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPtg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 47519929    476 -QPL-VAVLIDSGDTYYFGGCLDNSSGSGCKSPLGGFQGCLRLITIGDKAVD 525
Cdd:pfam00054   80 eSPLgATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
212-341 8.74e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.57  E-value: 8.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    212 FKAMQSNGILLHREGQ-HGNHITLELIKGKLVFFLNSGNAklpstiaPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDK 290
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQtERDFLALELRDGRLEVSYDLGSG-------AAVVRSGDKLNDGKWHSVELERNGRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 47519929    291 -HTHHF-QAKGDSSYLDLNFEISFGGIPTPG--RSRAFRRKSFHGCLENLYYNGV 341
Cdd:pfam00054   74 eARPTGeSPLGATTDLDVDGPLYVGGLPSLGvkKRRLAISPSFDGCIRDVIVNGK 128
LamG smart00282
Laminin G domain;
1042-1173 3.33e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.05  E-value: 3.33e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    1042 ITLSFRTTRTPSLLLYVSSFYE-EYLSVILaNNGSLQIRYKLDrhQNPDAFTFDFKNMADGQLHQVKINREEAVVMVEVN 1120
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 47519929    1121 QSTK-KQVILSSGTEFNAVKSLILGKVLEAAGADPDTrraATSGFTGCLSAVRF 1173
Cdd:smart00282   79 GGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1042-1173 3.73e-12

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 65.52  E-value: 3.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929 1042 ITLSFRTTRTPSLLLYVSSFYE-EYLSVILaNNGSLQIRYKLdrhqNPDAFTFDFKN-MADGQLHQVKINREEAVVMVEV 1119
Cdd:cd00110   24 ISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDL----GSGSLVLSSKTpLNDGQWHSVSVERNGRSVTLSV 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 47519929 1120 NQSTKKQVILSSGTEF-NAVKSLILGKVLEAAGADPDTRRAatsGFTGCLSAVRF 1173
Cdd:cd00110   99 DGERVVESGSPGGSALlNLDGPLYLGGLPEDLKSPGLPVSP---GFVGCIRDLKV 150
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 591-633 1.05e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 52.18  E-value: 1.05e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 47519929   591 SCEA--HKHRGNPSGLYYIDADGSGPLGPFLVYCNMTAD-AAWTVV 633
Cdd:NF040941    1 SCWEilQAGPSAPSGVYWIDPDGMGGLAPFQVYCDMTTDgGGWTLV 46
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 590-635 3.09e-05

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 46.46  E-value: 3.09e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 47519929  590 QSC-EAHKHRGNPSGLYYIDADGSGPlgPFLVYCNM-TADAAWTVVQH 635
Cdd:cd00087    4 RDCsEVLQRGGRTSGVYTIQPPGSNE--PFQVYCDMdTDGGGWTVIQR 49
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 593-635 1.18e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 44.96  E-value: 1.18e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47519929     593 EAHKHRGNPSGLYYIDADGSGPlgPFLVYCNMTADA-AWTVVQH 635
Cdd:smart00186    7 DVLQNGGKTSGLYTIYPDGSSR--PLKVYCDMETDGgGWTVIQR 48
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-582 2.16e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47519929    551 CLPSYCEHGGECSQSWDTFSCDCLgTGYTGET 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 798-946 2.70e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 42.76  E-value: 2.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47519929    798 NTETSYLHFPAF---HGELTadVCFFFKTTVSSG---VFMeNLGITDFIRIELRAPTEVTFSFDVGNGPcEVTVQSPTPF 871
Cdd:pfam13385    1 DGGSDYVTLPDAllpTSDFT--VSAWVKPDSLPGwarAII-SSSGGGGYSLGLDGDGRLRFAVNGGNGG-WDTVTSGASV 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47519929    872 NDNQWHHVRAERNVKGASLQVDQLPQKMQPAPadGHVRLQLNSQLFIGGTATRQRGFLGCIRSLQLNGVALDLEE 946
Cdd:pfam13385   77 PLGQWTHVAVTYDGGTLRLYVNGVLVGSSTLT--GGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAE 149
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 549-583 1.71e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.71e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 47519929  549 DRCL-PSYCEHGGECSQSWDTFSCDCLgTGYTGETC 583
Cdd:cd00054    3 DECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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