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Conserved domains on  [gi|16079999|ref|NP_390825|]
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acetate kinase [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

acetate kinase( domain architecture ID 10011301)

acetate kinase catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.1
Gene Ontology:  GO:0008776|GO:0016310|GO:0000287|GO:0006085|GO:0005524
PubMed:  16678422

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-395 0e+00

acetate kinase A/propionate kinase 2; Reviewed


:

Pssm-ID: 234680  Cd Length: 402  Bit Score: 754.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    3 KIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISV-NGEKNTEVTDIPDHAVAVKMLLNKLT--EFGIIKD 79
Cdd:PRK00180   2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVdGGEKEEEELPIPDHAEALKFLLNTLTdgKLGLIKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   80 LNEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYL 159
Cdd:PRK00180  82 LDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  160 YSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTR 239
Cdd:PRK00180 162 YALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  240 SGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMS 319
Cdd:PRK00180 242 SGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALN 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16079999  320 G-VDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNN--VRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRLAK 395
Cdd:PRK00180 322 GrLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRLLG 400
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-395 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 754.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    3 KIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISV-NGEKNTEVTDIPDHAVAVKMLLNKLT--EFGIIKD 79
Cdd:PRK00180   2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVdGGEKEEEELPIPDHAEALKFLLNTLTdgKLGLIKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   80 LNEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYL 159
Cdd:PRK00180  82 LDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  160 YSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTR 239
Cdd:PRK00180 162 YALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  240 SGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMS 319
Cdd:PRK00180 242 SGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALN 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16079999  320 G-VDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNN--VRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRLAK 395
Cdd:PRK00180 322 GrLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRLLG 400
AckA COG0282
Acetate kinase [Energy production and conversion];
2-395 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 736.08  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   2 SKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISV-NGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDL 80
Cdd:COG0282   1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGIIKDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  81 NEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY 160
Cdd:COG0282  81 DEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 161 SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRS 240
Cdd:COG0282 161 ALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 241 GNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSG 320
Cdd:COG0282 241 GDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGG 320

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16079999 321 VDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRLAK 395
Cdd:COG0282 321 LDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 4-393 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 681.93  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   4 IIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISV-NGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNE 82
Cdd:cd24010   1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVnNGEKIKEELPIPDHEEALKAILDTLTDPELGVSLDE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  83 IDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLYSL 162
Cdd:cd24010  81 IDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 163 PYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRSGN 242
Cdd:cd24010 161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 243 IDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVD 322
Cdd:cd24010 241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16079999 323 AIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNVR-GEEAFISYPHSPVKVMIIPTDEEVMIARDVVRL 393
Cdd:cd24010 321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-388 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 663.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999     3 KIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISVNGE-KNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLN 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGkKNAALLAGADHSEALNFILNTLLKHKIIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    82 EIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLYS 161
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   162 LPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRSG 241
Cdd:pfam00871 161 LPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   242 NIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGV 321
Cdd:pfam00871 241 DIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16079999   322 DAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIAR 388
Cdd:pfam00871 321 DAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-395 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 652.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999     1 MSKIIAINAGSSSLKFQLFEMPS-ETVLTKGLVERIGIADS-VFTISVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIK 78
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVNgEEVLASGLAERIFLPNArIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIIK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    79 DLNEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFK--EVLPNVPAVAVFDTAFHQTMPEQ 156
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALklFPLPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   157 SYLYSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAM 236
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   237 GTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAA 316
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIA 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   317 RMSG-VDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNN--VRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRL 393
Cdd:TIGR00016 323 SLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaaRSGKSGVISTPESKVKILVIPTNEELMIAQDAIRL 402


                  ..
gi 16079999   394 AK 395
Cdd:TIGR00016 403 TK 404
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-395 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 754.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    3 KIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISV-NGEKNTEVTDIPDHAVAVKMLLNKLT--EFGIIKD 79
Cdd:PRK00180   2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVdGGEKEEEELPIPDHAEALKFLLNTLTdgKLGLIKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   80 LNEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYL 159
Cdd:PRK00180  82 LDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  160 YSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTR 239
Cdd:PRK00180 162 YALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  240 SGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMS 319
Cdd:PRK00180 242 SGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALN 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16079999  320 G-VDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNN--VRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRLAK 395
Cdd:PRK00180 322 GrLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRLLG 400
AckA COG0282
Acetate kinase [Energy production and conversion];
2-395 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 736.08  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   2 SKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISV-NGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDL 80
Cdd:COG0282   1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGIIKDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  81 NEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY 160
Cdd:COG0282  81 DEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 161 SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRS 240
Cdd:COG0282 161 ALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 241 GNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSG 320
Cdd:COG0282 241 GDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGG 320

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16079999 321 VDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRLAK 395
Cdd:COG0282 321 LDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 4-393 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 681.93  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   4 IIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISV-NGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNE 82
Cdd:cd24010   1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVnNGEKIKEELPIPDHEEALKAILDTLTDPELGVSLDE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  83 IDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLYSL 162
Cdd:cd24010  81 IDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 163 PYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRSGN 242
Cdd:cd24010 161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 243 IDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVD 322
Cdd:cd24010 241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16079999 323 AIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNVR-GEEAFISYPHSPVKVMIIPTDEEVMIARDVVRL 393
Cdd:cd24010 321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-388 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 663.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999     3 KIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISVNGE-KNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLN 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGkKNAALLAGADHSEALNFILNTLLKHKIIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    82 EIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLYS 161
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   162 LPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRSG 241
Cdd:pfam00871 161 LPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   242 NIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGV 321
Cdd:pfam00871 241 DIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16079999   322 DAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIAR 388
Cdd:pfam00871 321 DAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-395 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 652.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999     1 MSKIIAINAGSSSLKFQLFEMPS-ETVLTKGLVERIGIADS-VFTISVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIK 78
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVNgEEVLASGLAERIFLPNArIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIIK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    79 DLNEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFK--EVLPNVPAVAVFDTAFHQTMPEQ 156
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALklFPLPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   157 SYLYSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAM 236
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   237 GTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAA 316
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIA 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   317 RMSG-VDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNN--VRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRL 393
Cdd:TIGR00016 323 SLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaaRSGKSGVISTPESKVKILVIPTNEELMIAQDAIRL 402


                  ..
gi 16079999   394 AK 395
Cdd:TIGR00016 403 TK 404
PRK12397 PRK12397
acetate/propionate family kinase;
1-394 0e+00

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 559.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    1 MS-KIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKD 79
Cdd:PRK12397   1 MSyKIMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADAQVTIKTHSQKWQETVPVADHRDAVTLLLEKLLGYQIINS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   80 LNEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYL 159
Cdd:PRK12397  81 LRDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAYI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  160 YSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTR 239
Cdd:PRK12397 161 YPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGTR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  240 SGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMS 319
Cdd:PRK12397 241 SGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQMG 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16079999  320 GVDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNvrGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRLA 394
Cdd:PRK12397 321 GLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQ--RNATFIQTENALVKVAVINTNEELMIAQDVMRIA 393
PRK07157 PRK07157
acetate kinase; Provisional
 1-393 8.86e-155

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 442.26  E-value: 8.86e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    1 MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDL 80
Cdd:PRK07157   2 KAKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLENGLIKIKFGKKKYEKEVDMPNHKVAVAVLIEIWEENKLIEDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   81 NEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY 160
Cdd:PRK07157  82 EEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINYTY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  161 SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRplKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRS 240
Cdd:PRK07157 162 PINYEIAKKYGIKKYGFHGISHKFITNKVEKILNK--DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTRS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  241 GNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSG 320
Cdd:PRK07157 240 GDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKIGK 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16079999  321 -VDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNVR----GEEAFISYPHSPVKVMIIPTDEEVMIARDVVRL 393
Cdd:PRK07157 320 kIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKKigeyGPIELISTPDSDIPVYVIRTNEELLIAKNAIKL 397
PRK12379 PRK12379
propionate kinase;
4-395 7.03e-151

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 432.24  E-value: 7.03e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    4 IIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVftISVNGEKNTEVTDiPDHAVAVKMLLNKLTEFGIIKDLNei 83
Cdd:PRK12379   7 VLVINCGSSSIKFSVLDASDCEVLMSGIADGINSENAF--LSVNGGEPAPLAH-HSYEGALKAIAFELEKRNLNDSVA-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   84 dGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLYSLP 163
Cdd:PRK12379  82 -LIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGLP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  164 YEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTRSGNI 243
Cdd:PRK12379 161 WEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  244 DPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDA 323
Cdd:PRK12379 241 DFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLHRLDG 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16079999  324 IIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNV--RGEEAFISYPHSPVKVMIIPTDEEVMIARDVVRLAK 395
Cdd:PRK12379 321 IIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQpnSGGERIISSENSRVICAVIPTNEEKMIALDAIHLGK 394
PRK12440 PRK12440
acetate/propionate family kinase;
2-393 4.10e-133

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 386.91  E-value: 4.10e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    2 SKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTISVNGEKNTEVTDIPD--HAVAVKMLLNKLTEFGIIKD 79
Cdd:PRK12440   4 SYVLVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLEDARMSWKYQGEKTEIAIEGEDnhHKIAIGRLVGLTEELGFTQD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   80 lneIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYL 159
Cdd:PRK12440  84 ---IVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAFT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  160 YSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGTR 239
Cdd:PRK12440 161 GAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGTR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  240 SGNIDPALIPYIMEKtGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMS 319
Cdd:PRK12440 241 CGDLDPGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAALD 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16079999  320 GVDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALN-NVR-GEEAFISYPHS-PVKVMIIPTDEEVMIARDVVRL 393
Cdd:PRK12440 320 SLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNeDARfGKAGIIAKSELlNAVAMVIPTNEEFVIAQQSVEL 396
PRK07058 PRK07058
acetate/propionate family kinase;
8-389 1.07e-104

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 314.68  E-value: 1.07e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999    8 NAGSSSLKFQLFEMPSETVltkglvERIGIADSVFT---ISVNGEKNTEVTDIPDHAVAVKMLLNKLTE-FGIIK---DL 80
Cdd:PRK07058  10 NAGSSTVKIGLFEVDGNEA------RRIGKGDIDFRrapLRFHLRNGGETLDIPLKASVTDDLHTVLDEtFDWLAahfDV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   81 NEIDGIGHRVVHGGEKFSDSVLLTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY 160
Cdd:PRK07058  84 SELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQPDLVRRF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  161 SLPYEYYEKfGIRKYGFHGTSHKYVterAAELLGR--PLKDLRLISCHLGNGASIAAVEGGKSIDTSMGFTPLAGVAMGT 238
Cdd:PRK07058 164 AIPRALHDE-GIKRYGFHGLSYKFV---AGELRRRapELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGIPMAT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  239 RSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGISGFSSDLRDIVEATKEGnerAETALEVFASRIHKYIGSYAARM 318
Cdd:PRK07058 240 RCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLLASDAPE---AREALDLFALRIAGEIARLAATL 316

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16079999  319 SGVDAIIFTAGIGENSVEVRERVLRGLEFMGVYWDPALNNvrgEEAF-ISYPHSPVKVMIIPTDEEVMIARD 389
Cdd:PRK07058 317 GGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANA---ANAFtISSRTSRVAAFVIPTDEEQVIADE 385
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 3-349 6.28e-33

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 126.11  E-value: 6.28e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999   3 KIIAINAGSSSLKFQLFEmpsetvLTKGLVERigiadsvfTISVNGEKNTEVTDIPD-HAVAVKMLLNKLTEFGIikDLN 81
Cdd:cd24011   1 RILVINPGSTSTKIAVFE------GEEEVFEE--------TIEHSPEELAKFPSIIDqLEFRKEAVLDFLKENGI--DLS 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  82 EIDGIGHRV-----VHGGEKFSDSVLLTD-ETIKEIEDISELAPL--HNPANIVGIKAFkevlpnvpavaVFDTAFHQTM 153
Cdd:cd24011  65 DLDAIVGRGgllkpIPGGTYRVNEAMLEDlLSGPLGEHASNLGAPiaYELAKEYGIPAY-----------IVDPVVVDEM 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 154 PEQSYLYSLPyeyyekfGI-RKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMG----- 227
Cdd:cd24011 134 DPVARITGIP-------EIeRRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgeg 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999 228 -FTPlagvamgTRSGNID-PALIPYImEKTGQTADEVLNTLNKKSGLLGISGfSSDLRDIVEATKEGNERAETALEVFAS 305
Cdd:cd24011 207 pFSP-------ERAGTLPvGDLIKLC-FSGKYTLEELKKKLKGKGGLVAYLG-TNDFREVEKRIEAGDEKAKLVLDAMAY 277

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 16079999 306 RIHKYIGSYAARMSG-VDAIIFTAGIGeNSVEVRERVLRGLEFMG 349
Cdd:cd24011 278 QIAKEIGALAAVLKGkVDAIILTGGLA-YSKRLVDRIKERVGFIA 321
PRK03011 PRK03011
butyrate kinase; Provisional
 173-349 1.84e-26

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 108.71  E-value: 1.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  173 RKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEGGKSIDTSMG------FTPLagvamgtRSGNIdPA 246
Cdd:PRK03011 149 RKSIFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSPE-------RAGGL-PV 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16079999  247 --LIPYImEKTGQTADEVLNTLNKKSGLLGISGfSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSG-VDA 323
Cdd:PRK03011 221 gdLVELC-FSGKYTKEELKKKLVGKGGLVAYLG-TNDAREVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKGkVDA 298

                        170       180
                 ....*....|....*....|....*.
gi 16079999  324 IIFTAGIgENSVEVRERVLRGLEFMG 349
Cdd:PRK03011 299 IVLTGGL-AYSKRLVERIKERVSFIA 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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