|
Name |
Accession |
Description |
Interval |
E-value |
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
1-539 |
5.39e-161 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 468.87 E-value: 5.39e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 1 MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQYGYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETS 80
Cdd:COG5841 2 KKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYKGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 81 RKMLKAGMSVMLVTGMIAFFILYLSAPMFAEISLGGkdnngltiDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT 160
Cdd:COG5841 82 RRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGD--------PRAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 161 AVSQVVEQIVRIIFLLSATFLILKVfngGLVIAVGYATFAALIGAFGGLVVLYIYWNKRKGSLLAMMPNTGPTANLSYKK 240
Cdd:COG5841 154 AVSQVIEQIVRVIFILLLAYLLLPY---GLEYAAAGATFGAVIGALAGLLVLLYYYRKRKKKLKRLLEKSKTKSKESSKD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 241 MFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIEAG-HQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITES 319
Cdd:COG5841 231 ILKELLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAGlSASEATSLYGILSGMAQPLVNLPTVLATALATSLVPAISEA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 320 FTSGNYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESlhpelGANILLWYSPVAILFSLFTVNAAILQGI 399
Cdd:COG5841 311 FAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPE-----GGGILAILAPSAIFLSLQQVTTGILQGL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 400 NKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIMIKRHAGYSYKiLVKRTVLMLVLSAIMGIA 479
Cdd:COG5841 386 GKQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLD-LRRRLLKPLLASLIMGIV 464
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 480 VKIVQWVLGFFIsyQDGQMQAAIVVVIAAAVGGAVYLYCGYRLGFLQKILGRRLPGFFRK 539
Cdd:COG5841 465 VLLLYRLLSLFL--PESRLGALLATLIAVLVGAIVYLLLLLKLGLITKEELRRLPKGGKK 522
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
10-457 |
1.23e-136 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 403.00 E-value: 1.23e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 10 FVLTLGTYISRILGMVYLIPFSIMVGATGGALFQYGYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMS 89
Cdd:cd13124 1 LILTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRVSLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 90 VMLVTGMIAFFILYLSAPMFAEISLGGkdnngltiDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQVVEQI 169
Cdd:cd13124 81 LLLILGLVFFLLLFFGAPFLAQLLLGD--------PRLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 170 VRIIFLLSATFLILKVfNGGLVIAVGYATFAALIGAFGGLVVLYIYWNKRKGSLLAmMPNTGPTANLSYKKMFFELFSYA 249
Cdd:cd13124 153 VRVIVILVLAYLLLPV-GGGLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKR-LLRKSPRSKISTKEILKELLSYA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 250 APYVFVGLAIPLYNYIDTNTFNKAMIEAG-HQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLL 328
Cdd:cd13124 231 IPITLSSLILPLLQLIDSFTVPRRLQAAGlSESEATALYGILTGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKEL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 329 NQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESlhpelGANILLWYSPVAILFSLFTVNAAILQGINKQKFAVVS 408
Cdd:cd13124 311 RRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE-----GGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVIN 385
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 16080057 409 LVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIMIKRHAGY 457
Cdd:cd13124 386 LLIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
5-320 |
3.11e-41 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 149.76 E-value: 3.11e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 5 LLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQYGYNQYTLFLNIATMGFPAAVSKFVSKYNSKgdYETSRKML 84
Cdd:pfam01943 1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREK--YELVSLYW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 85 KAGMSVMLVTGMIAFFILYLsapmfaeislggKDNNGLTIDHVVYVIRMVSLaLLVVPIMSLVRGFFQGHQMMGPTAVSQ 164
Cdd:pfam01943 79 LNALLVKLVLVLLFLLLPLI------------AAFLGLPELAVLYRILALMF-LLLPGVVQFRRGLFQGLERMKYALISQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 165 VVEQIVRIIFLLSATFLILKvfnggLVIAVGYATFAALIGAFGGLVVLYIYWNKRKgsllammpntgptaNLSYKKMFFE 244
Cdd:pfam01943 146 IVESLSRVILVFIAVFLPGD-----IVAALLYQVLAALVGGIIALAVLRKIFRPRF--------------VFPSLKLVRK 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080057 245 LFSYAAPYVFVGLAIPLYNYIDTNtFNKAMIEAGHqaisqdmLAILTLYVQKLVMIPVSLATAFGLTLIPTITESF 320
Cdd:pfam01943 207 LLSFGAPLFISSLAISLYTYIDSI-LLGLLLGAGA-------VGIYNAAYQLLVAIQGLLNPIVTAVLFPVFSKLQ 274
|
|
| spore_V_B |
TIGR02900 |
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ... |
5-454 |
9.95e-41 |
|
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]
Pssm-ID: 274343 [Multi-domain] Cd Length: 488 Bit Score: 153.60 E-value: 9.95e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 5 LLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQYGYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKML 84
Cdd:TIGR02900 1 FLKGTFILTIANLITRILGFIFRIVLSRILGAEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKKIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 85 KAGMSVMLVTGMIAFFILYLSAPMFAEislggkdnNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQ 164
Cdd:TIGR02900 81 KVSLIFTLIWSLIVTAIVFLLSPFIAS--------TLLKDERSLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 165 VVEQIVRIIFLLSATFLILkvfNGGLVIAVGYATFAALIGAFGGLVVLYIYWNKRKGSLLAMMPNTGPTanlSYKKMFFE 244
Cdd:TIGR02900 153 VIEQIVRISVVALLISAFL---PYGLEYAVAGAYLSLVLGELVSLLYLYFFFKRKKSFSIRFPFFDYKS---EGKALLFD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 245 LFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIEAG---HQAISQdmLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFT 321
Cdd:TIGR02900 227 LFSVSLPLTLSRFIGSLLYFLETLLVPQRLVIAGvtyREATSL--YGKLSGMAMPLLTFPAVITSSLSTALVPDISEAMA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 322 SGNYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLhpelgANILLWYSPVAILFSLFTVNAAILQGINK 401
Cdd:TIGR02900 305 KKNYSSIEKRINQAIKISLLLGLITTVILLVIPDELGALFYGRPDA-----GNFIRVLAPSFPFLYFSAPLQSILQGLGK 379
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 16080057 402 QKFAVVSLVIGVVIKLVL-----NVPLIKLMqadGAILATALGYIASLLYGFIMIKRH 454
Cdd:TIGR02900 380 QKVALRNSLIGAIVKIILlfvltSIPSINIY---GYAITFIITSVLVTILNLAEIKKN 434
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
5-452 |
3.05e-33 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 130.74 E-value: 3.05e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 5 LLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQYGYNQYTLFLNIATMGFPAAVSKFVSKYNskgdYETSRKML 84
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYR----KEKIREII 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 85 KAGMSVMLVTGMIAFFILYLSAPMFAEISLGgkdnngltidhVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQ 164
Cdd:cd13128 77 STSLVLKLILGILALLLLFLFAFLIAFYDPE-----------LVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIAR 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 165 VVEQIVRIIFllsatFLILKVFNGGLVIAVgyatFAALIGAFGGLVVLYIYWNKRKGSLLAMMPNtgptanlsyKKMFFE 244
Cdd:cd13128 146 IIESVLSLIL-----ALILVLLGGGLIGFA----LAYLIASVLSAILLLYIYRKKILLPKFFSFD---------LKLAKE 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 245 LFSYAAPYVFVGLAIPLYNYIDTntfnkAMIEaghQAISQDMLAILTlYVQKLVMIPVSLATAFGLTLIPTITESFTSgN 324
Cdd:cd13128 208 LLRFSIPLALSGIFSLIYTRIDT-----IMLG---YFLGDAAVGIYN-AAYRIAELLLFIPSAISTALFPRISELYKN-D 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 325 YKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLhpeLGANILLWYSPVAILFSLFTVNAAILQGINKQKF 404
Cdd:cd13128 278 KDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYL---PAALVLQILAWGFLFIFLNGIFGSILQAIGKQKL 354
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 16080057 405 AVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIMIK 452
Cdd:cd13128 355 TLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
6-492 |
7.86e-23 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 101.77 E-value: 7.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 6 LRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGA-LFQYGYNQYTLFLNI-ATMGFPAAVSKFVSKYNSKGDYETSRKM 83
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVAdAFFVAFRIPNLLRRLfAEGALSAAFVPVLAEALEKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 84 LKAGMSVMLVTGMIAFFILYLSAPMFAEISLGGKDnnGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVS 163
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGFD--PEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 164 QVVEQIVRIIFLLsatFLILKVFNGGLVIAVGyatfaALIGAFGGLVVLYIYWNKRKGSLLAMMPNTGPTANlsykkmff 243
Cdd:COG0728 159 PVLLNLVIIAGLL---LLAPLFGPGIYALAWG-----VLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGVR-------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 244 ELFSYAAPYVFVGLAIPLYNYIDTNTfnKAMIEAGhqAISqdmlaILTlYVQKLVMIPVSL-ATAFGLTLIPTITESFTS 322
Cdd:COG0728 223 RVLKLMLPALLGVSVSQINLLVDTIL--ASFLPEG--SVS-----ALY-YADRLYQLPLGLfGVAIGTALLPRLSRAAAA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 323 GNYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPE---LGANILLWYSPVAILFSLFTVNAAILQGI 399
Cdd:COG0728 293 GDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERGAFTAEdtaLTALALAAYALGLPAFALVKVLARAFYAR 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 400 NKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIMIKRHAGY-SYKILVKRTVLMLVLSAIMGI 478
Cdd:COG0728 373 QDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGGlPLRGILRTLLKLLLASLVMGA 452
|
490
....*....|....
gi 16080057 479 AVKIVQWVLGFFIS 492
Cdd:COG0728 453 VLWLLLRLLGDWLG 466
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
3-448 |
3.78e-22 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 98.10 E-value: 3.78e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 3 SKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQYGYNQYTLFLNIATMGFPAAVSKFVSKYNSkgdyETSRK 82
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYRE----EELRR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 83 MLKAGMSVMLVTGMIAFFILYLSAPMFAEIslggkdnngLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAV 162
Cdd:COG2244 78 LLSTALLLRLLLSLLLALLLLLLAPFIAAL---------LGEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLAL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 163 SQVVEQIVRIIFllsatflilkvfngglviavgyatfaALIGAFGGLVVLYIywnkrkgsllammpntgptanlsykkmf 242
Cdd:COG2244 149 INILSSLLSLLL--------------------------ALLLALLGLGLWGL---------------------------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 243 feLFSYAAPYVFVGLAIPLYNYIDtntfnKAMIEAghqAISQDMLAILTLyVQKLVMIPVSLATAFGLTLIPTITESFTS 322
Cdd:COG2244 175 --VLKYSLPLLLSGLLGLLLTNLD-----RLLLGA---LLGPAAVGIYSA-AYRLASLLLLLITALSQVLFPRLSRLLAE 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 323 GNYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHpelGANILLWYSPVAILFSLFTVNAAILQGINKQ 402
Cdd:COG2244 244 GDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE---AAPVLPILALGALFLALSGVLSNLLLALGRT 320
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 16080057 403 KFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGF 448
Cdd:COG2244 321 RLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
375-492 |
3.33e-17 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 78.38 E-value: 3.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 375 ILLWYSPVAILFSLFTVNAAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIMIKRH 454
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRY 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 16080057 455 AGYSYKIlvKRTVLMLVLSAIMGIAVKIVQWVLGFFIS 492
Cdd:pfam14667 81 LGLRLLL--RRLLKPLLAALVMGIVVYLLLLLLGLLLG 116
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
14-454 |
1.10e-15 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 79.03 E-value: 1.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 14 LGTYISRILGMVYLIPFSIMVGATGGA-LFQYGYNQYTLFLNIATMG-FPAAVSKFVSKYNSKGDYETSRKMLKAGMSVM 91
Cdd:cd13123 2 IGTLLSRILGFVRDVLIAAAFGAGPLAdAFFVAFRIPNLLRRLFAEGaLSAAFVPVFSEYLEKEGEEEARRFASRVLTLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 92 LVTGMIAFFILYLSAPMFAEISLGGKDNNglTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQVVEQIVR 171
Cdd:cd13123 82 LLVLLLLTLLGILFAPLLVKLLAPGFSGD--KFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 172 IIFLLsatFLILKVFNGGLVIAVGyatfaALIGAFGGLVVLYIYWNKRKGSLLAMMPNTGPtanlsYKKMFFELFsyaAP 251
Cdd:cd13123 160 IAGLL---LLAPLFDLGIYALAWG-----VLLGGVLQLLVQLPALRRLGFRFRPRLDFRDP-----GVRRVLKLM---LP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 252 YVFVGLAIPLYNYIDTNtFNKAMIEAGHQAISqdmlailtlYVQKLVMIPVSL-ATAFGLTLIPTITESFTSGNYKLLNQ 330
Cdd:cd13123 224 ALLGVSVSQINLLVDTI-LASFLPEGSISALY---------YADRLYQLPLGIfGVAIATALLPRLSRLAAAGDLDEFRR 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 331 QINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPE---LGANILLWYSPVAILFSLFTVNAAILQGINKQKFAVV 407
Cdd:cd13123 294 TLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERGAFTAEdtlMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVK 373
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 16080057 408 SLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIMIKRH 454
Cdd:cd13123 374 IAVIAVAVNILLNLLLIKPLGHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
4-497 |
1.21e-14 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 76.59 E-value: 1.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 4 KLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGA-LFQYGYNQYTLFLNI-ATMGFPAAVSKFVSKYNSKGDYETSR 81
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTAdAFNVAFVIPNFFRRLfAEGAFNSAFVPVFTKAKKKEKEARRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 82 KMLKAGMSVMLVTGMI-------AFFILYLSAPMFAEIslggkdnnglTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGH 154
Cdd:TIGR01695 81 FANTVTTLLILSLLLVvligiffAPFVISLLAPGFADE----------TRSLAVSLTRIMFPYLLLISLAAVFGGILNAR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 155 QMMGPTAVSQVVEQIVRIIFLLsatflilkVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNKRKGSLLAMMPNTGPTA 234
Cdd:TIGR01695 151 KRFFIPSFSPILFNIGVILSLL--------FFDWNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFRDPGL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 235 NLSYKKMFFELFSYAAPYvfVGLAIplynyidtNTFNKAMIEAGHQAISQDMLAILTLyvqKLVMIPVSLATAfgltLIP 314
Cdd:TIGR01695 223 KRFLKLFLPTTLGSSASQ--ITLLI--------NTALASFLEIGSVSALYYANRIYQL---PLGIFGISLSTV----LLP 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 315 TITESFTSGNYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPE---LGANILLWYSPVAILFSLFTV 391
Cdd:TIGR01695 286 KLSRHASEGNWNELRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGAFSEEdtvMTATILAAYGLGLIFYSLQKV 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 392 NAAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIMIKRHAGYSYKILVKRTVLMLV 471
Cdd:TIGR01695 366 LLRAFYARKDTRTPFINSVISVVLNALLSLLLIFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPFGVLKVLAKLV 445
|
490 500
....*....|....*....|....*.
gi 16080057 472 lsaimgIAVKIVQWVLGFFISYQDGQ 497
Cdd:TIGR01695 446 ------IASAIIGGVLYLIVSVSLGG 465
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
14-449 |
2.07e-12 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 68.89 E-value: 2.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 14 LGTYISRILGMVYLIPFSIMVGATGG----ALFQYGYNQYTLFlnIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMS 89
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGdalaAVGLAFPLIALLI--ALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 90 VMLVTGMIAFFILYLSAPMFAEISLGGKDNNGLTIDHVvyviRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQVVEQI 169
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYL----TILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 170 VRIIFLLSATFLIlkvfnGGLVIAVGYATFAALIGAFGGLVVLYIYWNKRKGSLLammpnTGPTANLSYKKMFFELFSYA 249
Cdd:cd12082 156 LNILLDPLLIFGL-----GPPELGIAGAALATVISYVIGALLLLIYLRKGKKILK-----FKLSLLKPDLELLRRLLRIG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 250 APYVFVGLAIPLYNYIDTNTfnkamieaGHQAISQDMLAILTLYVQkLVMIPVSLATAFGLTLIPTITESFTSGNYKLLN 329
Cdd:cd12082 226 LPSAIQNSLLSLGLLIIVAI--------VAAFGGAAALAAYTVAFR-IASLAFMPALGLAQAALPVVGQNLGAGNFDRAR 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 330 QQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESlHPELGANILLWYSPVAILFSLFTVNAAILQGINKQKFA-VVS 408
Cdd:cd12082 297 RITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPE-FLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSlIVS 375
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 16080057 409 LVIGVVIKLVLNVPLIKL-MQADGAILATALGYIASLLYGFI 449
Cdd:cd12082 376 LLSYWVVRLPLAYVLAYLgLGLYGIWLALVISLILAALVLLL 417
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
90-491 |
1.55e-10 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 63.46 E-value: 1.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 90 VMLVTGMIAFfILYLSAPMFAEISLGGKDNNGLTIdhVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQVVEQI 169
Cdd:pfam03023 63 LILVLLLVTL-IGILAAPWLIRLLAPGFDPETFSL--AVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 170 VRIIFLLsatflILKVFNGGLVIAVGYATfaaLIGAFGGLVVLYIYWNKRKGSLLAMMPNTGPTANLSYKKMFFELFSYA 249
Cdd:pfam03023 140 GVILTLL-----LLANYLGNAIYALAIGV---LIGGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 250 APYVfvGLAIplynyidtNTFNKAMIEAGHQAISQdmlailtlYVQKLVMIPVSL-ATAFGLTLIPTITESFTSGNYKLL 328
Cdd:pfam03023 212 VSQL--NLLI--------DTFLASFLAPGSVSYLY--------YADRIYQLPLGIfGVSISTVLLPRLSRHAADGDWDEF 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 329 NQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPE---LGANILLWYSPVAILFSLFTVNAAILQGINKQKFA 405
Cdd:pfam03023 274 RDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFSPEdvtATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTP 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 406 VVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGF-IMIKRHAGYSYKILVKRTVLMLVLSAIMGIAV---- 480
Cdd:pfam03023 354 FKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLVFLYyILRKRLGGFDLRGIKTFLASLVVPTALMAGVIllls 433
|
410
....*....|...
gi 16080057 481 --KIVQWVLGFFI 491
Cdd:pfam03023 434 slTQGPWVVGSLL 446
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
236-454 |
3.05e-09 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 59.00 E-value: 3.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 236 LSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTntfnkAMIeaGHqaISQDMLAILTLYVQkLVMIPVSLATAFGLTLIPT 315
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDT-----IFV--GR--LGTAALAAVGLAFP-IFFLLIALGIGLGVGGTAL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 316 ITESFTSGNYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPeLGANILLWYSPVAILFSLFTVNAAI 395
Cdd:COG0534 71 VAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLA-LARDYLRIILLGLPFLLLFNVLNGI 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16080057 396 LQGINKQKFAVVSLVIGVVIKLVLNVPLIKL--MQADGAILATALGYIASLLYGFIMIKRH 454
Cdd:COG0534 150 LRGLGDTKTPMIIMLIGNVLNIVLDPLLIFGggLGVAGAALATVISQAVSALLLLYYLFRK 210
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
47-450 |
4.95e-08 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 55.15 E-value: 4.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 47 NQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFILYLSAPMFAEIsLGGKDNnglTIDH 126
Cdd:COG0534 50 FPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRL-LGADPE---VLAL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 127 VVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQVVEQIVRIIflLSATFlilkVFNGGL-VIAVGYATfaaLIGA 205
Cdd:COG0534 126 ARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNIV--LDPLL----IFGGGLgVAGAALAT---VISQ 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 206 FGGLVVLYIYWNKRKGSLLAMMPNTGPTanlsyKKMFFELFSYAAPYVFVGLAIPLYNYIdtntFNKAMIEAGHQAisqd 285
Cdd:COG0534 197 AVSALLLLYYLFRKRSLLRLRLRDLRPD-----RKILKRILRIGLPAGLQQLAESLGFLV----LNALVARLGTAA---- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 286 mLAILTlYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSE 365
Cdd:COG0534 264 -VAAYG-IALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDP 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 366 SLHpELGANILLWYSPVAILFSLFTVNAAILQGINKqkfAVVSLVIGVVIKLVLNVPLIKL-----MQADGAILATALGY 440
Cdd:COG0534 342 EVI-ALAATYLRIAALFQPFDGLQFVLSGALRGAGD---TRFPMIISLLRLWLVRLPLAYLlaflgLGLTGVWLALPIGE 417
|
410
....*....|
gi 16080057 441 IASLLYGFIM 450
Cdd:COG0534 418 VLRALLLLLR 427
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
314-453 |
2.81e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 49.63 E-value: 2.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 314 PTITESFTSGNYKLLNQQINQTMQTILFLIIPAVVgISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVNA 393
Cdd:cd12082 56 ALISQAIGAGDEEKARRVLVQSIVLAILLGLLLAA-LLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLS 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16080057 394 AILQGINKQKFAVVSLVIGVVIKLVLNVPLI-----KLMQADGAILATALGYIASLLYGFIMIKR 453
Cdd:cd12082 135 GILQGEGDTRTAMIISVLSNLLNILLDPLLIfglgpPELGIAGAALATVISYVIGALLLLIYLRK 199
|
|
| MATE_epsE_like |
cd13129 |
Multidrug and toxic compound extrusion family and similar proteins; This model represents a ... |
4-446 |
2.37e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins, including Ralstonia solanaceraum GMI1000 epsE, which may be involved in exporting exopolysaccharide EPS I, a virulence factor. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240534 [Multi-domain] Cd Length: 411 Bit Score: 46.71 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 4 KLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQYGYNQYTLFLNIATMGFPAAVSKFVSKYNSkGDYETSRKM 83
Cdd:cd13129 1 SFASGSFWSLGGLVASRGAVFLTNIMVARSLGKHVFGEFGVIQVTIGLLGTFAGFGLGLAATKVIAETKD-VDPERAGRI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 84 LKAGMSVMLVTGMIAFFILYLSAPMFAEISLGGKdnngltidHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVS 163
Cdd:cd13129 80 IGLSILLAVVTGALAATVLFLSATWIAIATLNAP--------HLAELLRIAAIILILTAFTGAQTGFLSGFEAFRAIARV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 164 QVVEQivriiFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNKRkgsllammpntGPTANLSYKKMFF 243
Cdd:cd13129 152 NIWAG-----LLLLPLMWIGVYIRGLVGAVVILLASAAGNVASNSLILRRECQNQR-----------GPVRTGLTWQELR 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 244 ELFSYAAPYVFVGLAIPLYNYIDTNTFnkamieaghqAISQDMLAILTLY--VQKLVMIPVSLATAFGLTLIPTITESFt 321
Cdd:cd13129 216 VLFKFSLPSVLSGSMGSPVHWIALAIL----------VNQPNGYAELGLFnaANQWRQFITFLPATLGNVALPFLAENF- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 322 SGNYKLLNQQINQTMQTILFLIIPAVVgISLLSGPTYTFFYGSESlhpELGANILLWYSPVAILFSLFTVNAAILQGINK 401
Cdd:cd13129 285 GNNEGMFRQTFRSALLFGLGLSLPLGC-VFILASQIFAWLYGKEY---GSAAASMRSLAVAAILVGLSVLLGQIIASSGK 360
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 16080057 402 QKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLY 446
Cdd:cd13129 361 IWRGFALNMVWSVIYVAAAYLLLRLYGAPGLALAMSAAYCVLIIF 405
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
47-219 |
2.87e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 46.68 E-value: 2.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 47 NQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFILYLSAPMFAEISLggkdNNGLTIDH 126
Cdd:cd13138 267 NKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFT----SDPEVIEI 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 127 VVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQVVEQIVRIIFLLsatFLILKVFNGGLViAVGYATFAALIGAF 206
Cdd:cd13138 343 GAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLA---YLLSRLTGLGLF-GIWLAMPISNILSA 418
|
170
....*....|...
gi 16080057 207 GGLVVLYIYWNKR 219
Cdd:cd13138 419 IICIIYYRKGRWK 431
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
245-478 |
2.02e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 44.04 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 245 LFSYAAPYVFVGLAIPLYNYIDTntfnkamIEAGHqAISQDMLAILTLyVQKLVMIPVSLATAFGLTLIPTITESFTSGN 324
Cdd:cd13143 6 FLKFALPAIIGMLVNGLYNIVDG-------IFVGH-GVGALALAAVNL-VFPIIMLLMALGLMIGVGGASLISRRLGAGD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 325 YKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPeLGANILLWYSPVAILFSLFTVNAAILQGINKQKF 404
Cdd:cd13143 77 REKANRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLP-YAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKL 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080057 405 AVVSLVIGVVIKLVLNVPLIKLMQAD--GAILATALGYIASLLYGFIMIKRHAGYSYKILVKRTVLMLVLSAIMGI 478
Cdd:cd13143 156 AMLGMLIGAVLNIILDPLFIFVLGLGiaGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILAL 231
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
303-453 |
3.25e-04 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 43.00 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 303 SLATAFGLTLIPTITESFTSGNYKLLNQQINQTMqTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPV 382
Cdd:TIGR00797 43 SILMGLGTATTALVAQAVGAGNYQRLGRQAQQSL-LLALLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILG 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16080057 383 AILFSLFTVNAAILQGINKQKFAVVSLVIGVVIKLVLNVPLI----KLMQADGAILATALGYIASLLYGFIMIKR 453
Cdd:TIGR00797 122 IPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNYILIfgkfGFLGIVGAALATVISYWLMFLLLLYYIKK 196
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
244-454 |
4.41e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 42.88 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 244 ELFSYAAPYVFVGLAIPLYNYIDtntfnkaMIEAGHqaISQDMLAILTLYVQkLVMIPVSLATAFGLTLIPTITESFTSG 323
Cdd:cd13137 2 RIWSLAWPVILENLLQTLVGLVD-------VFMVGR--LGAEAIAAVGLATQ-VLWLLLVLNMALGTGTVALVSQSYGAG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 324 NYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPeLGANILLWYSPVAILFSLFTVNAAILQGINKQK 403
Cdd:cd13137 72 DYERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIA-LALTYLRIVLLGIPFFFLSLVGNAALRGAGDTK 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 16080057 404 FAVVSLVIGVVIKLVLNVPLI------KLMQADGAILATALGYIASLLYGFIMIKRH 454
Cdd:cd13137 151 TPMYIMIIVNVLNIVLDYVLIfglwgfPGLGVAGAALATVISRVVGALLLLFLLLRG 207
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
15-206 |
4.42e-03 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 39.74 E-value: 4.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 15 GTYISRILGMVYLIPFSIMVGATGGALFQYGyNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVT 94
Cdd:COG0534 240 LQQLAESLGFLVLNALVARLGTAAVAAYGIA-LRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGI 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 95 GMIAFFILYLSAPMFAEISLggkdNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQVVEQ-IVRII 173
Cdd:COG0534 319 GLLLALLLFLFPEPIIGLFT----DDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLwLVRLP 394
|
170 180 190
....*....|....*....|....*....|...
gi 16080057 174 FLLSATFLILKVFngGLVIAVGYATFAALIGAF 206
Cdd:COG0534 395 LAYLLAFLGLGLT--GVWLALPIGEVLRALLLL 425
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
90-464 |
7.67e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 38.62 E-value: 7.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 90 VMLVTGMIAFFILYLSAPMFAEIslggkdnngLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQVVEQI 169
Cdd:cd13127 77 LNLLLGLLLYLLLFLLAPLIAAF---------YNEPELIPLLRVLSLSFLLSGLGSVPRALLQRELRFKKLAIIELISTL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 170 VRIIFLLSATFLILKVFngGLVIAvgyatfaALIGAFGGLVVLYIYWNKRkgsllammpntgPTANLSYKKmFFELFSYA 249
Cdd:cd13127 148 VSGVVAIVLALLGFGVW--ALVAQ-------QLVGALVSTVLLWILSRWR------------PRLSFSLAS-LKELLSFG 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 250 APYVFVGLAIPLYNYIDTNTFNKAMieaghqaiSQDMLAILTLyVQKLVMIPVS-LATAFGLTLIPTITEsfTSGNYKLL 328
Cdd:cd13127 206 SKLLGSNLLNYFSRNLDNLIIGKFL--------GAAALGYYSR-AYRLALLPVQnITGPITRVLFPALSR--LQDDPERL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 329 NQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLhpeLGANILLWYSPVAILFSLFTVNAAILQGINKQ----KF 404
Cdd:cd13127 275 RRAYLKALRLLALITFPLMVGLALLAEPLVLLLLGEKWL---PAVPILQILALAGLFQPLSSLNGSLLLALGRTdlllKL 351
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 405 AVVSLVIGVVIkLVLNVPLiklmQADGAILATALGYIASLLYGFIMIKRHAGYSYKILVK 464
Cdd:cd13127 352 GLIKAVLTVLA-LLIGIPY----GIIGVAIAYVIASLLSFPLNLYLAGRLIGISLLELLR 406
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
297-420 |
8.89e-03 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 37.16 E-value: 8.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080057 297 LVMIPVSLATAfgltLIPTITESFTSGNYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHpELGANIL 376
Cdd:pfam01554 41 IFMFLLGLGTA----LTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLVLLFSEPILSLFGQDEEVL-ALAKRYL 115
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 16080057 377 LWYSPVAILFSLFTVNAAILQGINKQKFAVVSLVIGVVIKLVLN 420
Cdd:pfam01554 116 RILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
|
| |
