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Conserved domains on  [gi|16128197|ref|NP_414746|]
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putative S-adenosylmethionine-dependent methyltransferase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 7-112 1.13e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 107.00  E-value: 1.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   7 GRPTFGAAQNVSAVVAYDLSAHMLDVVAQAAEARQLkNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNR 86
Cdd:COG2226  34 GRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIAR 112

                        90       100
                ....*....|....*....|....*.
gi 16128197  87 ILKPGGRLIVMDVMSPGHPVRDIWLQ 112
Cdd:COG2226 113 VLKPGGRLVVVDFSPPDLAELEELLA 138
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 7-112 1.13e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 107.00  E-value: 1.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   7 GRPTFGAAQNVSAVVAYDLSAHMLDVVAQAAEARQLkNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNR 86
Cdd:COG2226  34 GRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIAR 112

                        90       100
                ....*....|....*....|....*.
gi 16128197  87 ILKPGGRLIVMDVMSPGHPVRDIWLQ 112
Cdd:COG2226 113 VLKPGGRLVVVDFSPPDLAELEELLA 138
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 7-96 2.97e-26

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 96.58  E-value: 2.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197     7 GRPTFGAAQNVSAVVAYDLSAHMLDVVAQAAEARQLkniTTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNR 86
Cdd:pfam08241   8 GLLTELLARLGARVTGVDISPEMLELAREKAPREGL---TFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIAR 84

                          90
                  ....*....|
gi 16128197    87 ILKPGGRLIV 96
Cdd:pfam08241  85 VLKPGGILII 94
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 13-114 1.68e-17

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 77.50  E-value: 1.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   13 AAQNVSAVVAYDLSAHMLDVVAQAAEARQL-KNITTRQGYAESLPFADNAFDIV-ISrYSAHHWHDVGAALREVNRILKP 90
Cdd:PRK00216  72 AVGKTGEVVGLDFSEGMLAVGREKLRDLGLsGNVEFVQGDAEALPFPDNSFDAVtIA-FGLRNVPDIDKALREMYRVLKP 150

                         90       100
                 ....*....|....*....|....*...
gi 16128197   91 GGRLIVMDVMSPGHP----VRDIWLQTV 114
Cdd:PRK00216 151 GGRLVILEFSKPTNPplkkAYDFYLFKV 178
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 20-114 1.30e-15

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 72.30  E-value: 1.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197    20 VVAYDLSAHMLDVVAQAAEARQlkNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIVMDV 99
Cdd:TIGR01934  67 VTGVDFSSEMLEVAKKKSELPL--NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEF 144

                          90
                  ....*....|....*....
gi 16128197   100 MSPGH----PVRDIWLQTV 114
Cdd:TIGR01934 145 SKPANallkKFYKFYLKNV 163
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 7-99 3.40e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.22  E-value: 3.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   7 GRPTFGAAQNVSA-VVAYDLSAHMLDVVAQAAEARQLKNITTRQGYAESLPF-ADNAFDIVISRYSAHHWH-DVGAALRE 83
Cdd:cd02440  10 GALALALASGPGArVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLVeDLARFLEE 89

                        90
                ....*....|....*.
gi 16128197  84 VNRILKPGGRLIVMDV 99
Cdd:cd02440  90 ARRLLKPGGVLVLTLV 105
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
23-147 2.69e-03

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 37.40  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197     23 YDLSAHMLDVVAQAAEARQLKN-ITTRQGYAESLPFADNaFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIVMDVMS 101
Cdd:smart00828  29 YTISPEQAEVGRERIRALGLQGrIRIFYRDSAKDPFPDT-YDLVFGFEVIHHIKDKMDLFSNISRHLKDGGHLVLADFIA 107

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 16128197    102 PG-----HPVRDIWLQTVEalrdtshvrnyasgEWLTLINEANLIVDNLIT 147
Cdd:smart00828 108 NLlsaieHEETTSYLVTRE--------------EWAELLARNNLRVVEGVD 144
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 7-112 1.13e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 107.00  E-value: 1.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   7 GRPTFGAAQNVSAVVAYDLSAHMLDVVAQAAEARQLkNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNR 86
Cdd:COG2226  34 GRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIAR 112

                        90       100
                ....*....|....*....|....*.
gi 16128197  87 ILKPGGRLIVMDVMSPGHPVRDIWLQ 112
Cdd:COG2226 113 VLKPGGRLVVVDFSPPDLAELEELLA 138
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 7-96 2.97e-26

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 96.58  E-value: 2.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197     7 GRPTFGAAQNVSAVVAYDLSAHMLDVVAQAAEARQLkniTTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNR 86
Cdd:pfam08241   8 GLLTELLARLGARVTGVDISPEMLELAREKAPREGL---TFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIAR 84

                          90
                  ....*....|
gi 16128197    87 ILKPGGRLIV 96
Cdd:pfam08241  85 VLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 7-92 3.07e-22

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 86.46  E-value: 3.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197     7 GRPTFGAAQNVSA-VVAYDLSAHMLDVVAQAAEARQLkNITTRQGYAESLPFADNAFDIVISRYSAHHWH--DVGAALRE 83
Cdd:pfam13649   9 GRLTLALARRGGArVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPdpDLEAALRE 87


                  ....*....
gi 16128197    84 VNRILKPGG 92
Cdd:pfam13649  88 IARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 7-98 6.22e-18

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 76.21  E-value: 6.22e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   7 GRPTFGAAQNVSAVVAYDLSAHMLDVVAQAAEARqlkNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNR 86
Cdd:COG2227  36 GRLALALARRGADVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELAR 112

                        90
                ....*....|..
gi 16128197  87 ILKPGGRLIVMD 98
Cdd:COG2227 113 LLKPGGLLLLST 124
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 13-114 1.68e-17

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 77.50  E-value: 1.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   13 AAQNVSAVVAYDLSAHMLDVVAQAAEARQL-KNITTRQGYAESLPFADNAFDIV-ISrYSAHHWHDVGAALREVNRILKP 90
Cdd:PRK00216  72 AVGKTGEVVGLDFSEGMLAVGREKLRDLGLsGNVEFVQGDAEALPFPDNSFDAVtIA-FGLRNVPDIDKALREMYRVLKP 150

                         90       100
                 ....*....|....*....|....*...
gi 16128197   91 GGRLIVMDVMSPGHP----VRDIWLQTV 114
Cdd:PRK00216 151 GGRLVILEFSKPTNPplkkAYDFYLFKV 178
PRK08317 PRK08317
hypothetical protein; Provisional
 20-178 2.21e-16

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 74.59  E-value: 2.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   20 VVAYDLSAHMLDVVAQAAEArQLKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIVMD- 98
Cdd:PRK08317  47 VVGIDRSEAMLALAKERAAG-LGPNVEFVRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDt 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   99 -----VMSPGHP--VRDIwlqtVEALRDtsHVRNYASGEWL-TLINEANLIVDN-----LITDKLPLEFSSWvARMRTPE 165
Cdd:PRK08317 126 dwdtlVWHSGDRalMRKI----LNFWSD--HFADPWLGRRLpGLFREAGLTDIEvepytLIETDLKEADKGF-GLIRAAR 198

                        170
                 ....*....|...
gi 16128197  166 ALVDAIRIYQQSA 178
Cdd:PRK08317 199 RAVEAGGISADEA 211
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 20-114 1.30e-15

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 72.30  E-value: 1.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197    20 VVAYDLSAHMLDVVAQAAEARQlkNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIVMDV 99
Cdd:TIGR01934  67 VTGVDFSSEMLEVAKKKSELPL--NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEF 144

                          90
                  ....*....|....*....
gi 16128197   100 MSPGH----PVRDIWLQTV 114
Cdd:TIGR01934 145 SKPANallkKFYKFYLKNV 163
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
10-105 2.97e-13

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 65.92  E-value: 2.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197    10 TFGAAQNVSA---VVAYDLSAHMLDVVAQAAEARQLKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNR 86
Cdd:pfam01209  57 TFGLSDSAGSsgkVVGLDINENMLKEGEKKAKEEGKYNIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFR 136

                          90
                  ....*....|....*....
gi 16128197    87 ILKPGGRLIVMDVMSPGHP 105
Cdd:pfam01209 137 VLKPGGRVVCLEFSKPENP 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 7-99 3.40e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.22  E-value: 3.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   7 GRPTFGAAQNVSA-VVAYDLSAHMLDVVAQAAEARQLKNITTRQGYAESLPF-ADNAFDIVISRYSAHHWH-DVGAALRE 83
Cdd:cd02440  10 GALALALASGPGArVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLVeDLARFLEE 89

                        90
                ....*....|....*.
gi 16128197  84 VNRILKPGGRLIVMDV 99
Cdd:cd02440  90 ARRLLKPGGVLVLTLV 105
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 7-139 5.04e-13

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 63.98  E-value: 5.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197     7 GRPTFGAAQNV---SAVVAYDLSAHMLDVVAQAAEARQLKNITTRQGYAESLP--FADNAFDIVISRYSAHHWHDVGAAL 81
Cdd:pfam13847  15 GHLSFELAEELgpnAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPelLEDDKFDVVISNCVLNHIPDPDKVL 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16128197    82 REVNRILKPGGRLIVMDVmspghpvrDIWLQTVEALRDTSHVRN------YASGEWLTLINEAN 139
Cdd:pfam13847  95 QEILRVLKPGGRLIISDP--------DSLAELPAHVKEDSTYYAgcvggaILKKKLYELLEEAG 150
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 13-102 5.30e-13

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 64.94  E-value: 5.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197  13 AAQNVSAVVAYDLSAHMLDVVAQAAEARQLKNITTRQG-YAESLPFADNAFDIVISRYSAHHW--HDVGAALREVNRILK 89
Cdd:COG0500  45 AARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAdLAELDPLPAESFDLVVAFGVLHHLppEEREALLRELARALK 124

                        90
                ....*....|...
gi 16128197  90 PGGRLIVMDVMSP 102
Cdd:COG0500 125 PGGVLLLSASDAA 137
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 7-94 1.31e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 55.84  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197     7 GRPTFGAAQNV--SAVVAYDLSAHMLDVVAQAAEARQLKNITTRQGYAESLPFAD-NAFDIVISRYSAHHWHDVGAALRE 83
Cdd:pfam08242   8 GTLLRALLEALpgLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDpGSFDVVVASNVLHHLADPRAVLRN 87

                          90
                  ....*....|.
gi 16128197    84 VNRILKPGGRL 94
Cdd:pfam08242  88 IRRLLKPGGVL 98
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
20-96 7.36e-10

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 54.06  E-value: 7.36e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128197  20 VVAYDLSAHMLdvvaqaAEARQ-LKNITTRQGYAESLPFADNaFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIV 96
Cdd:COG4106  28 VTGVDLSPEML------ARARArLPNVRFVVADLRDLDPPEP-FDLVVSNAALHWLPDHAALLARLAAALAPGGVLAV 98
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 7-111 1.02e-09

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 56.82  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197    7 GRPTFGAAQNVSA--VVAYDLSAHMLdvvAQAAEARQLKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREV 84
Cdd:PLN02490 125 GFTTLGIVKHVDAknVTILDQSPHQL---AKAKQKEPLKECKIIEGDAEDLPFPTDYADRYVSAGSIEYWPDPQRGIKEA 201

                         90       100       110
                 ....*....|....*....|....*....|.
gi 16128197   85 NRILKPGGRLIVMDVMSPGHPVR----DIWL 111
Cdd:PLN02490 202 YRVLKIGGKACLIGPVHPTFWLSrffaDVWM 232
arsM PRK11873
arsenite methyltransferase;
11-99 1.13e-09

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 56.50  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   11 FGAAQNVSA---VVAYDLSAHMLDVVAQAAEARQLKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRI 87
Cdd:PRK11873  93 FLAARRVGPtgkVIGVDMTPEMLAKARANARKAGYTNVEFRLGEIEALPVADNSVDVIISNCVINLSPDKERVFKEAFRV 172

                         90
                 ....*....|..
gi 16128197   88 LKPGGRLIVMDV 99
Cdd:PRK11873 173 LKPGGRFAISDV 184
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 7-96 4.31e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 53.39  E-value: 4.31e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   7 GRPTFGAAQNVSA-VVAYDLSAHMLDVVAQAAEARQLKN-ITTRQGYAESLPfADNAFDIVISRYSAHH--WHDVGAALR 82
Cdd:COG2230  63 GGLALYLARRYGVrVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDLP-ADGQFDAIVSIGMFEHvgPENYPAYFA 141

                        90
                ....*....|....
gi 16128197  83 EVNRILKPGGRLIV 96
Cdd:COG2230 142 KVARLLKPGGRLLL 155
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
14-146 3.10e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.54  E-value: 3.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197  14 AQNVSAVVAYDLSAHMLDVvaqaAEARQLKnITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGR 93
Cdd:COG4976  65 RPRGYRLTGVDLSEEMLAK----AREKGVY-DRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGL 139

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 16128197  94 LIVmdvmspghpvrdiwlqTVEALrDTSHVRNYASGEWLTLINEANLIVDNLI 146
Cdd:COG4976 140 FIF----------------SVEDA-DGSGRYAHSLDYVRDLLAAAGFEVPGLL 175
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
55-96 3.17e-08

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 51.02  E-value: 3.17e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 16128197  55 LPFADNAFDIVisrYSAH---H--WHDVGAALREVNRILKPGGRLIV 96
Cdd:COG4627  40 LPFPDNSVDAI---YSSHvleHldYEEAPLALKECYRVLKPGGILRI 83
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 18-94 8.07e-08

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 50.91  E-value: 8.07e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128197   18 SAVVAYDLSAHMLdvvaqaAEARQlKNITTR--QGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGRL 94
Cdd:PRK10258  65 SQVTALDLSPPML------AQARQ-KDAADHylAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVV 136
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 13-140 1.55e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 48.96  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197    13 AAQNVSAVVAYDLSAHMldvvaqaaEARQLKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGG 92
Cdd:pfam13489  40 LRAQGFSVTGVDPSPIA--------IERALLNVRFDQFDEQEAAVPAGKFDVIVAREVLEHVPDPPALLRQIAALLKPGG 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 16128197    93 RLIVMDVMSPGHpvRDIWLQTVEALRDTS-HVRNYASGEWLTLINEANL 140
Cdd:pfam13489 112 LLLLSTPLASDE--ADRLLLEWPYLRPRNgHISLFSARSLKRLLEEAGF 158
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 20-106 2.00e-07

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 49.89  E-value: 2.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   20 VVAYDLSAHMLDVVA--QAAEARQ-LKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIV 96
Cdd:PLN02233 101 VMGLDFSSEQLAVAAsrQELKAKScYKNIEWIEGDATDLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPGSRVSI 180

                         90
                 ....*....|
gi 16128197   97 MDVMSPGHPV 106
Cdd:PLN02233 181 LDFNKSTQPF 190
PRK05785 PRK05785
hypothetical protein; Provisional
 20-87 2.49e-06

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 46.60  E-value: 2.49e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128197   20 VVAYDLSAHMLDVVAQAAEarqlknitTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRI 87
Cdd:PRK05785  77 VVALDYAENMLKMNLVADD--------KVVGSFEALPFRDKSFDVVMSSFALHASDNIEKVIAEFTRV 136
PLN02244 PLN02244
tocopherol O-methyltransferase
 35-96 1.06e-05

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 45.12  E-value: 1.06e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128197   35 QAAEARqlkNITTRQGYAE----------SLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIV 96
Cdd:PLN02244 153 QAARAN---ALAAAQGLSDkvsfqvadalNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIII 221
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 24-98 1.24e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 43.91  E-value: 1.24e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128197   24 DLSAHMLDVVA--QAAEARQ-LKNITTRQGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIVMD 98
Cdd:PLN02232   4 DFSSEQLAVAAtrQSLKARScYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSILD 81
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 20-97 2.39e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 43.01  E-value: 2.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197  20 VVAYDLSAHMLDVVAQAAEARQLKNITTRQGYAESLPFADNAFDIVIS-----RYSAHHWHD----VGAALREVNRILKP 90
Cdd:COG1041  51 VIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPLADESVDAIVTdppygRSSKISGEEllelYEKALEEAARVLKP 130


                ....*..
gi 16128197  91 GGRLIVM 97
Cdd:COG1041 131 GGRVVIV 137
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 11-105 2.06e-04

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 41.27  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197   11 FGAAQNVSA-VVAYDLSAHMLDVVAQAAEAR------QLKNITTRQgyaeslpFADNAFDIVISRYSAHHWHDVGAALRE 83
Cdd:PLN02336 282 FYMAENFDVhVVGIDLSVNMISFALERAIGRkcsvefEVADCTKKT-------YPDNSFDVIYSRDTILHIQDKPALFRS 354

                         90       100
                 ....*....|....*....|...
gi 16128197   84 VNRILKPGGRLIVMD-VMSPGHP 105
Cdd:PLN02336 355 FFKWLKPGGKVLISDyCRSPGTP 377
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 24-97 7.91e-04

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 38.98  E-value: 7.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197  24 DLSAHMLD-------VVAQAAEARQLKNITTRQGYAESLPfADNAFDIVISR----------YSAHHwhdvgaalrevnr 86
Cdd:COG0357  91 DLQVTLVDslgkkiaFLREVVRELGLKNVTVVHGRAEELA-PREKFDVVTARavaplpdlleLALPL------------- 156

                        90
                ....*....|.
gi 16128197  87 iLKPGGRLIVM 97
Cdd:COG0357 157 -LKPGGRLLAL 166
Methyltransf_29 pfam03141
Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative ...
 55-92 1.18e-03

Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase.


Pssm-ID: 335237 [Multi-domain]  Cd Length: 506  Bit Score: 39.21  E-value: 1.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16128197    55 LPFADNAFDIvisrysAH------HWH-DVGAALREVNRILKPGG 92
Cdd:pfam03141 175 LPYPSRSFDL------AHcsrcriPWTaNDGILLLEVDRVLRPGG 213
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
23-147 2.69e-03

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 37.40  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128197     23 YDLSAHMLDVVAQAAEARQLKN-ITTRQGYAESLPFADNaFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIVMDVMS 101
Cdd:smart00828  29 YTISPEQAEVGRERIRALGLQGrIRIFYRDSAKDPFPDT-YDLVFGFEVIHHIKDKMDLFSNISRHLKDGGHLVLADFIA 107

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 16128197    102 PG-----HPVRDIWLQTVEalrdtshvrnyasgEWLTLINEANLIVDNLIT 147
Cdd:smart00828 108 NLlsaieHEETTSYLVTRE--------------EWAELLARNNLRVVEGVD 144
Methyltransf_8 pfam05148
Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic ...
 55-124 7.98e-03

Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic proteins which are related to methyltransferases pfam01209.


Pssm-ID: 398698  Cd Length: 214  Bit Score: 35.95  E-value: 7.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128197    55 LPFADNAFDIVISRYS--AHHWHDVgaaLREVNRILKPGGRLIVMDVMSPGHPVRdIWLQTVEALR-DTSHVR 124
Cdd:pfam05148 111 VPLEDESVDVAVFCLSlmGTNIADF---LKEANRILKNGGLLKIAEVRSRFPSVG-LFERAFTKLGfEVEHVD 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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