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Conserved domains on  [gi|145698223|ref|NP_414880|]
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DNA-binding transcriptional activator MhpR [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

DNA-binding transcriptional activator MhpR( domain architecture ID 11484498)

DNA-binding transcriptional activator MhpR is an activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK09834 PRK09834
DNA-binding transcriptional regulator;
7-268 1.08e-143

DNA-binding transcriptional regulator;


:

Pssm-ID: 182100 [Multi-domain]  Cd Length: 263  Bit Score: 403.99  E-value: 1.08e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223   7 TEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDE 86
Cdd:PRK09834   2 TEYKTVRGLSRGLMVLRALNRLDGGATVGLLAELTGLHRTTVRRLLETLQEEGYVRRSASDDSFRLTLKVRQLSEGFRDE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  87 QWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQDRKELIE 166
Cdd:PRK09834  82 QWISALAAPLLGDLLRRVVWPTDLTTLDVDAMVIRETTHRFSPLSFHRAMVGRRLPLLLTAAGRAYLAFCPEEEREALLE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223 167 MLASRPGDDYQLAREPLKLEAILARARKEGYGQNYRGWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHL 246
Cdd:PRK09834 162 LLASRPGDEDQLARDPARLEAMLARTRKRGYGENYGGWDQQPKIASIAVPVRSGQRVLGCLNLVYIASAMSIEEAAKRYL 241
                        250       260
                 ....*....|....*....|..
gi 145698223 247 PALQRVAKQIEEGVESQAILVA 268
Cdd:PRK09834 242 PALQRAAKQIEAGVESQAILVA 263
 
Name Accession Description Interval E-value
PRK09834 PRK09834
DNA-binding transcriptional regulator;
7-268 1.08e-143

DNA-binding transcriptional regulator;


Pssm-ID: 182100 [Multi-domain]  Cd Length: 263  Bit Score: 403.99  E-value: 1.08e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223   7 TEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDE 86
Cdd:PRK09834   2 TEYKTVRGLSRGLMVLRALNRLDGGATVGLLAELTGLHRTTVRRLLETLQEEGYVRRSASDDSFRLTLKVRQLSEGFRDE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  87 QWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQDRKELIE 166
Cdd:PRK09834  82 QWISALAAPLLGDLLRRVVWPTDLTTLDVDAMVIRETTHRFSPLSFHRAMVGRRLPLLLTAAGRAYLAFCPEEEREALLE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223 167 MLASRPGDDYQLAREPLKLEAILARARKEGYGQNYRGWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHL 246
Cdd:PRK09834 162 LLASRPGDEDQLARDPARLEAMLARTRKRGYGENYGGWDQQPKIASIAVPVRSGQRVLGCLNLVYIASAMSIEEAAKRYL 241
                        250       260
                 ....*....|....*....|..
gi 145698223 247 PALQRVAKQIEEGVESQAILVA 268
Cdd:PRK09834 242 PALQRAAKQIEAGVESQAILVA 263
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
29-258 6.62e-42

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 144.19  E-value: 6.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  29 DGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPT 108
Cdd:COG1414   22 GGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGRYRLGPRLLELGSAALRRLDLRRLARPVLEELAEETGETV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223 109 DVSTLDVDAMVV--RETTHRFSRLSFHramVGRRLPLLKTASGLTWLAFCPEQDRKELIEMLASRPGDDYQLaREPLKLE 186
Cdd:COG1414  102 HLAVLDGDEVVYvaRVEGPRPVRVSSR---VGSRLPLHATASGKALLAFLPEEELEALLARAGLPRFTPNTI-TDPAALR 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145698223 187 AILARARKEGYGQNYRGWdqEEKIASIAVPLRSEQ-RVIGCLNLVYMASAMTIEQAAEkHLPALQRVAKQIEE 258
Cdd:COG1414  178 AELAEIRERGYAVDDGEL--EPGVRAVAAPVFDADgRVVAALSVSGPSSRLTEERLEE-LAPALRAAAREISR 247
pcaR_pcaU TIGR02431
beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this ...
33-257 1.62e-25

beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions]


Pssm-ID: 131484 [Multi-domain]  Cd Length: 248  Bit Score: 101.18  E-value: 1.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223   33 SVGLLAELSGLHRTTVRRLLETLQEEGYVRrspSDDS-FRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVS 111
Cdd:TIGR02431  26 TLTDVAEATGLTRAAARRFLLTLVELGYVT---SDGRlFWLTPRVLRLGYAYLSSAPLPKVAQPLLERLSAQTHESCSVA 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  112 TLDVDAMV--VRETTHRFSRLSFHramVGRRLPLLKTASGLTWLAFCPEQDRKELIEMLASRPGDDYQLArEPLKLEAIL 189
Cdd:TIGR02431 103 VLDGDEIVyvARSPTHRIMSVGLS---VGTRLPAYCTSMGRVLLAGLDDEELDEYLARSTLQALTPRTIT-DRDALLAEL 178
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145698223  190 ARARKEGYGQNyrgwDQEEKIA--SIAVPLRSEQ-RVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIE 257
Cdd:TIGR02431 179 LAVRAQGYALV----DQELELGlrSIAVPIRNARgQVVAALNVSTHAARTTPEELVERILPLLLEAARELR 245
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
12-102 8.36e-21

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 84.17  E-value: 8.36e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223    12 VRGLTRGLMLLNMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISA 91
Cdd:smart00346   1 IQSLERGLAVLRALAEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGRYRLGPKVLELGQSYLSSLDLRE 80
                           90
                   ....*....|.
gi 145698223    92 LAAPLLGDLLR 102
Cdd:smart00346  81 VAKPVLEELSR 91
IclR pfam01614
Bacterial transcriptional regulator; This family of bacterial transcriptional regulators ...
137-257 1.62e-08

Bacterial transcriptional regulator; This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. However this family covers the C-terminal region that binds to regulatory substrates including Glyoxylate, allantoin/ate, indole, aromatic hydrocarbons, sugar acids, succinic semialdehyde, benzoate derivatives, ascorbic acid, glycerol-3-phosphate, glyceraldehyde-3-phosphate and pyruvate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426346 [Multi-domain]  Cd Length: 128  Bit Score: 51.90  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  137 VGRRLPLLKTASGLTWLAFCPEQDRKELIEMLASRPGDDYQLArEPLKLEAILARARKEGYGQNYRgwDQEEKIASIAVP 216
Cdd:pfam01614   9 IGRRLPLHATAIGKALLAWLDEEELEAYLERYELKRLTPNTIT-DPEALLEELAQIREQGYAVDRE--EHELGVRCIAAP 85
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 145698223  217 LRSEQ-RVIGCLNLVymASAMTIEQAAEKHLPA-LQRVAKQIE 257
Cdd:pfam01614  86 IFDASgDVVAAISVS--GPTSRLTEEELDYLLAlLREAARKIS 126
 
Name Accession Description Interval E-value
PRK09834 PRK09834
DNA-binding transcriptional regulator;
7-268 1.08e-143

DNA-binding transcriptional regulator;


Pssm-ID: 182100 [Multi-domain]  Cd Length: 263  Bit Score: 403.99  E-value: 1.08e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223   7 TEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDE 86
Cdd:PRK09834   2 TEYKTVRGLSRGLMVLRALNRLDGGATVGLLAELTGLHRTTVRRLLETLQEEGYVRRSASDDSFRLTLKVRQLSEGFRDE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  87 QWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQDRKELIE 166
Cdd:PRK09834  82 QWISALAAPLLGDLLRRVVWPTDLTTLDVDAMVIRETTHRFSPLSFHRAMVGRRLPLLLTAAGRAYLAFCPEEEREALLE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223 167 MLASRPGDDYQLAREPLKLEAILARARKEGYGQNYRGWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHL 246
Cdd:PRK09834 162 LLASRPGDEDQLARDPARLEAMLARTRKRGYGENYGGWDQQPKIASIAVPVRSGQRVLGCLNLVYIASAMSIEEAAKRYL 241
                        250       260
                 ....*....|....*....|..
gi 145698223 247 PALQRVAKQIEEGVESQAILVA 268
Cdd:PRK09834 242 PALQRAAKQIEAGVESQAILVA 263
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
29-258 6.62e-42

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 144.19  E-value: 6.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  29 DGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPT 108
Cdd:COG1414   22 GGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGRYRLGPRLLELGSAALRRLDLRRLARPVLEELAEETGETV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223 109 DVSTLDVDAMVV--RETTHRFSRLSFHramVGRRLPLLKTASGLTWLAFCPEQDRKELIEMLASRPGDDYQLaREPLKLE 186
Cdd:COG1414  102 HLAVLDGDEVVYvaRVEGPRPVRVSSR---VGSRLPLHATASGKALLAFLPEEELEALLARAGLPRFTPNTI-TDPAALR 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145698223 187 AILARARKEGYGQNYRGWdqEEKIASIAVPLRSEQ-RVIGCLNLVYMASAMTIEQAAEkHLPALQRVAKQIEE 258
Cdd:COG1414  178 AELAEIRERGYAVDDGEL--EPGVRAVAAPVFDADgRVVAALSVSGPSSRLTEERLEE-LAPALRAAAREISR 247
pcaR_pcaU TIGR02431
beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this ...
33-257 1.62e-25

beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions]


Pssm-ID: 131484 [Multi-domain]  Cd Length: 248  Bit Score: 101.18  E-value: 1.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223   33 SVGLLAELSGLHRTTVRRLLETLQEEGYVRrspSDDS-FRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVS 111
Cdd:TIGR02431  26 TLTDVAEATGLTRAAARRFLLTLVELGYVT---SDGRlFWLTPRVLRLGYAYLSSAPLPKVAQPLLERLSAQTHESCSVA 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  112 TLDVDAMV--VRETTHRFSRLSFHramVGRRLPLLKTASGLTWLAFCPEQDRKELIEMLASRPGDDYQLArEPLKLEAIL 189
Cdd:TIGR02431 103 VLDGDEIVyvARSPTHRIMSVGLS---VGTRLPAYCTSMGRVLLAGLDDEELDEYLARSTLQALTPRTIT-DRDALLAEL 178
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145698223  190 ARARKEGYGQNyrgwDQEEKIA--SIAVPLRSEQ-RVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIE 257
Cdd:TIGR02431 179 LAVRAQGYALV----DQELELGlrSIAVPIRNARgQVVAALNVSTHAARTTPEELVERILPLLLEAARELR 245
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
12-102 8.36e-21

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 84.17  E-value: 8.36e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223    12 VRGLTRGLMLLNMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISA 91
Cdd:smart00346   1 IQSLERGLAVLRALAEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGRYRLGPKVLELGQSYLSSLDLRE 80
                           90
                   ....*....|.
gi 145698223    92 LAAPLLGDLLR 102
Cdd:smart00346  81 VAKPVLEELSR 91
PRK15090 PRK15090
DNA-binding transcriptional regulator KdgR; Provisional
37-218 8.45e-11

DNA-binding transcriptional regulator KdgR; Provisional


Pssm-ID: 185046 [Multi-domain]  Cd Length: 257  Bit Score: 60.80  E-value: 8.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  37 LAELS---GLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAP---LLGDLLREVVwptDV 110
Cdd:PRK15090  31 ITELSqrvMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELGAKALQNVDLIRSADIqmrEISRLTKETI---HL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223 111 STLDVDAMVVRETTHRFSRLSFHrAMVGRRLPLLKTASGLTWLAFCPEQDRKELIEMLASRPGDDYQLAREPLKLEaILA 190
Cdd:PRK15090 108 GALDEDSIVYIHKIDSMYNLRMY-SRIGRRNPLYSTAIGKVLLAWRDRDEVREILSGVEFKRSTEKTITSTEALLP-VLD 185
                        170       180
                 ....*....|....*....|....*...
gi 145698223 191 RARKEGYGQNYRgwDQEEKIASIAVPLR 218
Cdd:PRK15090 186 QVREQGYGEDNE--EQEEGLRCIAVPVF 211
IclR pfam01614
Bacterial transcriptional regulator; This family of bacterial transcriptional regulators ...
137-257 1.62e-08

Bacterial transcriptional regulator; This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. However this family covers the C-terminal region that binds to regulatory substrates including Glyoxylate, allantoin/ate, indole, aromatic hydrocarbons, sugar acids, succinic semialdehyde, benzoate derivatives, ascorbic acid, glycerol-3-phosphate, glyceraldehyde-3-phosphate and pyruvate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426346 [Multi-domain]  Cd Length: 128  Bit Score: 51.90  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  137 VGRRLPLLKTASGLTWLAFCPEQDRKELIEMLASRPGDDYQLArEPLKLEAILARARKEGYGQNYRgwDQEEKIASIAVP 216
Cdd:pfam01614   9 IGRRLPLHATAIGKALLAWLDEEELEAYLERYELKRLTPNTIT-DPEALLEELAQIREQGYAVDRE--EHELGVRCIAAP 85
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 145698223  217 LRSEQ-RVIGCLNLVymASAMTIEQAAEKHLPA-LQRVAKQIE 257
Cdd:pfam01614  86 IFDASgDVVAAISVS--GPTSRLTEEELDYLLAlLREAARKIS 126
HTH_IclR pfam09339
IclR helix-turn-helix domain;
29-65 3.37e-07

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 46.25  E-value: 3.37e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145698223   29 DGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSP 65
Cdd:pfam09339  16 PGPLTLTEIARRTGLPKSTAHRLLQTLVELGYVEQDP 52
PRK11569 PRK11569
glyoxylate bypass operon transcriptional repressor IclR;
12-208 9.21e-07

glyoxylate bypass operon transcriptional repressor IclR;


Pssm-ID: 183206 [Multi-domain]  Cd Length: 274  Bit Score: 49.04  E-value: 9.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  12 VRGLTRGLMLLNMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISA 91
Cdd:PRK11569  24 VQSLTRGLKLLEWIAESNGSVALTELAQQAGLPNSTTHRLLTTMQQQGFVRQVGELGHWAIGAHAFIVGSSFLQSRNLLA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698223  92 LAAPLLGDLLREVVWPTDVSTLDVD---AMVVRETT-HRFSRLSfhrAMVGRRLPLLKTASGLTWLAFCPEQDRKELIEM 167
Cdd:PRK11569 104 IVHPILRNLMEDSGETVNLAVLDQSdhqAIIIDQVQcTALMRMS---APIGGKLPMHASGAGKAFLAQLSEEQVTKLLHR 180
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 145698223 168 LASRPGDDYQLArEPLKLEAILARARKEGYgqnyrGWDQEE 208
Cdd:PRK11569 181 KGLHAYTHATLV-SPVHLKEDLAQTRKRGY-----SFDDEE 215
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
30-87 6.71e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.34  E-value: 6.71e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145698223    30 GGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDS-----FRLTIKVRQLSEGFRDEQ 87
Cdd:smart00347  23 GPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDrrsvlVSLTEEGRELIEQLLEAR 85
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
30-64 1.14e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 1.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 145698223  30 GGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRS 64
Cdd:COG2345   26 GPVTAAELAEALGLTPNAVRRHLDALEEEGLVERE 60
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
30-68 3.56e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 3.56e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 145698223   30 GGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDD 68
Cdd:pfam12802  18 PGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
30-71 4.07e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 34.83  E-value: 4.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 145698223   30 GGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFR 71
Cdd:pfam01047  16 GPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
30-68 5.49e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.49  E-value: 5.49e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 145698223  30 GGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDD 68
Cdd:COG1846   51 GGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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