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Conserved domains on  [gi|16128654|ref|NP_415204|]
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glucosamine-6-phosphate deaminase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10794581)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 0e+00

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


:

Pssm-ID: 129593  Cd Length: 259  Bit Score: 513.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654     1 MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    81 HPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   161 TLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 16128654   241 EPSTMELKVKTLRYFNELE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
 
Name Accession Description Interval E-value
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 0e+00

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 513.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654     1 MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    81 HPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   161 TLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 16128654   241 EPSTMELKVKTLRYFNELE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-261 8.47e-179

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 492.04  E-value: 8.47e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    1 MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   81 HPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  161 TLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|.
gi 16128654  241 EPSTMELKVKTLRYFNELEAE 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-247 2.68e-134

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 378.37  E-value: 2.68e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  10 EQVGKWAARHIVNRINAFKPtadrpFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFM 89
Cdd:cd01399   1 EEMSEAAAELIAELIREKPP-----AVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  90 HRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVA 169
Cdd:cd01399  76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128654 170 NSRFFDNDvNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMEL 247
Cdd:cd01399 156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 7.29e-119

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 339.83  E-value: 7.29e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   1 MRLIPLTTAEQVGKWAARHIVNRINAFkpTADRP-FVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPK 79
Cdd:COG0363   2 MRVIIFPDAEELAAAAAERAAERIAEA--IAEKGrAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  80 EHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRT-R 158
Cdd:COG0363  80 DHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdR 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654 159 IKTLTHDTRVANSRFFDNdVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMV 238
Cdd:COG0363 160 VVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWF 238

                       250
                ....*....|
gi 16128654 239 CDEPSTMELK 248
Cdd:COG0363 239 LDEAAASLLT 248
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
8-218 4.63e-24

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 96.54  E-value: 4.63e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654     8 TAEQVGKWAARHIVNRINAFkpTADR-PFVLGLPTGGTPMTTYKALVEMHkaGQVSFKHVVTFNMDE-YVglPKEHPESY 85
Cdd:pfam01182   2 DAEALAQALAERLAEALEAA--LAERgRFTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDSN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    86 YSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGK---------IHLfmgGVGNDGHIA--F-NEPAssL 153
Cdd:pfam01182  76 YGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvfdlVLL---GMGPDGHTAslFpGSPA--L 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16128654   154 ASRTRIKTLTHDTRVAnsrffdndvnqvPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEG 218
Cdd:pfam01182 151 EETDRLVVAVTDSPKP------------PPERITLTLPVLNAARRVWFLVTGAGKADALRRALAG 203
 
Name Accession Description Interval E-value
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 0e+00

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 513.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654     1 MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    81 HPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   161 TLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 16128654   241 EPSTMELKVKTLRYFNELE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-261 8.47e-179

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 492.04  E-value: 8.47e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    1 MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   81 HPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  161 TLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|.
gi 16128654  241 EPSTMELKVKTLRYFNELEAE 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 7.28e-148

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 413.38  E-value: 7.28e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    1 MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   81 HPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  161 TLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 16128654  241 EPSTMELKVKTLR 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-247 2.68e-134

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 378.37  E-value: 2.68e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  10 EQVGKWAARHIVNRINAFKPtadrpFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFM 89
Cdd:cd01399   1 EEMSEAAAELIAELIREKPP-----AVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  90 HRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVA 169
Cdd:cd01399  76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128654 170 NSRFFDNDvNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMEL 247
Cdd:cd01399 156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 7.29e-119

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 339.83  E-value: 7.29e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   1 MRLIPLTTAEQVGKWAARHIVNRINAFkpTADRP-FVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPK 79
Cdd:COG0363   2 MRVIIFPDAEELAAAAAERAAERIAEA--IAEKGrAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  80 EHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRT-R 158
Cdd:COG0363  80 DHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdR 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654 159 IKTLTHDTRVANSRFFDNdVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMV 238
Cdd:COG0363 160 VVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWF 238

                       250
                ....*....|
gi 16128654 239 CDEPSTMELK 248
Cdd:COG0363 239 LDEAAASLLT 248
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 13-239 1.83e-79

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 237.25  E-value: 1.83e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  13 GKWAARHIVNRINAFkPTADRPFVLGLPTGGTPMTTYKALVEMHKAGqvSFKHVVTFNMDEYVGLPKeHPESYYSFMHRN 92
Cdd:cd00458   1 AKEALKFIEDK*EKL-LEEKDDMVIGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPLD-SDQSNFRQAKLL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  93 FFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNdghiafnepasslasrtriktlthdtrvansr 172
Cdd:cd00458  77 AFEHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAGY-------------------------------- 124

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128654 173 ffdndvnqvpkyaltvgvgtllDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVC 239
Cdd:cd00458 125 ----------------------RAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 16-247 2.62e-79

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 251.49  E-value: 2.62e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   16 AARHIVNRINAF---KPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFMHRN 92
Cdd:PRK02122  39 ASRAVAQEIATLireRQAEGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQSYHRFMKEN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   93 FFDHVDIPAENINLLNGNAP--DIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVAN 170
Cdd:PRK02122 119 LFDHVDIPPENIHIPDGTIPkeEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVTLDHITRRDA 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128654  171 SRFFdNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMEL 247
Cdd:PRK02122 199 ASDF-FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLAAASEL 274
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 36-240 1.22e-32

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 119.16  E-value: 1.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   36 VLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDiD 115
Cdd:PRK09762  31 VICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-E 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  116 AECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDndvNQVPKYALTVGVGTLLD 195
Cdd:PRK09762 110 TECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLDARTQQHEMLKTA---GRPVTRGITLGLKDILN 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 16128654  196 AEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAI-MVCD 240
Cdd:PRK09762 187 AREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNFIcLIDR 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
8-218 4.63e-24

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 96.54  E-value: 4.63e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654     8 TAEQVGKWAARHIVNRINAFkpTADR-PFVLGLPTGGTPMTTYKALVEMHkaGQVSFKHVVTFNMDE-YVglPKEHPESY 85
Cdd:pfam01182   2 DAEALAQALAERLAEALEAA--LAERgRFTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDSN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    86 YSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGK---------IHLfmgGVGNDGHIA--F-NEPAssL 153
Cdd:pfam01182  76 YGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvfdlVLL---GMGPDGHTAslFpGSPA--L 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16128654   154 ASRTRIKTLTHDTRVAnsrffdndvnqvPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEG 218
Cdd:pfam01182 151 EETDRLVVAVTDSPKP------------PPERITLTLPVLNAARRVWFLVTGAGKADALRRALAG 203
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 10-218 1.67e-20

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 86.85  E-value: 1.67e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  10 EQVGKWAARHIVNRINAfKPTADRPFVLGLPTGGTPMTTYKALVEMHkagQVSFKHVVTFNMDE-YVglPKEHPESYYSF 88
Cdd:cd01400   1 EALAEALADRIAEALAA-AIAKRGRFSLALSGGSTPKPLYELLAAAP---ALDWSKVHVFLGDErCV--PPDDPDSNYRL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  89 MHRNFFDHVDIPAENINLLNGNApDIDAECRQYEEKIRS----YGKIHLFMGGVGNDGHIA--FNEPASSLASRTRIKTL 162
Cdd:cd01400  75 AREALLSHVAIPAANIHPIPTEL-GPEDAAAAYEKELRAlfggVPPFDLVLLGMGPDGHTAslFPGHPALLEETDRLVVA 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 16128654 163 THDTRVAnsrffdndvnqvPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEG 218
Cdd:cd01400 154 VTDSPKP------------PPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAG 197
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-247 5.05e-20

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 85.96  E-value: 5.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    1 MRLIPLTTAEQVGKWAARHIVNRInafkpTADRPFVLGLPTGGTPMTTYKALVEMHKaGQVSFKHVVTFNMDEYVGLPKE 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYM-----SKTKRVNLAITAGSTPKGMYEYLITLVK-GKAWYDNVHYYNFDEIPFRGKE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   81 HPESYYSFMHRNFFDHVDIPAENINLLN-GNApdidaecRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPA-SSLASRTR 158
Cdd:PRK12358  75 GEGVTITNLRNLFFTPAGIKEENIHKLTiDNY-------REHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDETV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  159 IKTLTHDTR--VANSRFfDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAI 236
Cdd:PRK12358 148 EVPIQGEMVdiVAHGEL-GGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLT 226

                        250
                 ....*....|.
gi 16128654  237 MVCDEPSTMEL 247
Cdd:PRK12358 227 VILDEAAAAEL 237
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 35-218 1.23e-16

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 76.64  E-value: 1.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654    35 FVLGLPTGGTPMTTYKALVEMhkagQVSFKHVVTFNMDE-YVglPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPD 113
Cdd:TIGR01198  30 FSLALSGGRSPIALLEALAAQ----PLDWSRIHLFLGDErYV--PLDHADSNTGLAREALLDRVAIPASNIHPMPTELSD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   114 IDAECRQYEEKIRSY------GKIHLFMGGVGNDGHIA--FNEpasSLASRTRIKTLThdtrvansrFFDNDVNQvPKYA 185
Cdd:TIGR01198 104 IEEAAELYEQELAAAfqpivfPVFDLLLLGMGPDGHTAslFPH---TPALQETERLVT---------VLTKSPKP-PHER 170

                         170       180       190
                  ....*....|....*....|....*....|...
gi 16128654   186 LTVGVGTLLDAEEVMILVLGSQKALALQAAVEG 218
Cdd:TIGR01198 171 ITLTLPAINAARKVFLLIAGEEKRNALAEALAV 203
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 69-219 4.21e-04

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 41.00  E-value: 4.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654   69 FNMDEYVgLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAeCRQYEEKIRSYGKIH--------------LF 134
Cdd:PLN02360  77 FWADERV-VAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEA-ATDYEFAIRQLVKTRtigvsdisdcpkfdLI 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128654  135 MGGVGNDGHIAF---NEPASSLasrtriktltHDTRVAnsrfFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALA 211
Cdd:PLN02360 155 LLGMGSDGHVASlfpNHPALEE----------KDDWVT----FITDSPKPPPERITFTLPVINSASNVAVVATGESKANA 220


                 ....*...
gi 16128654  212 LQAAVEGC 219
Cdd:PLN02360 221 VHLAIDDV 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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