|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09764 |
PRK09764 |
GntR family transcriptional regulator; |
1-240 |
1.60e-167 |
|
GntR family transcriptional regulator;
Pssm-ID: 182065 [Multi-domain] Cd Length: 240 Bit Score: 461.60 E-value: 1.60e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80
Cdd:PRK09764 1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 81 LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS 160
Cdd:PRK09764 81 LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR 240
Cdd:PRK09764 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR 240
|
|
| MngR |
COG2188 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
1-237 |
2.28e-84 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 250.93 E-value: 2.28e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80
Cdd:COG2188 1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 81 LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVME-N 159
Cdd:COG2188 81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLEtG 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128705 160 SKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRK 237
Cdd:COG2188 161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
|
|
| UTRA |
pfam07702 |
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ... |
90-229 |
6.07e-39 |
|
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 429607 [Multi-domain] Cd Length: 141 Bit Score: 131.95 E-value: 6.07e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 90 DRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMEN-SKYHFIEEV 168
Cdd:pfam07702 1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEER 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16128705 169 KKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
Cdd:pfam07702 81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
|
|
| trehalos_R_Bsub |
TIGR02404 |
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ... |
7-236 |
6.57e-38 |
|
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]
Pssm-ID: 274116 [Multi-domain] Cd Length: 233 Bit Score: 132.10 E-value: 6.57e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 7 YRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV-KEERVNYDIFQLTSFD 85
Cdd:TIGR02404 2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSFK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 86 EKLSDRHVDTHSEVLIFEV-IPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHF 164
Cdd:TIGR02404 82 ELNETLGLDSKTEVVELDKeDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQY 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128705 165 IEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQR 236
Cdd:TIGR02404 162 LENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
|
|
| UTRA |
smart00866 |
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ... |
90-229 |
2.82e-37 |
|
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.
Pssm-ID: 214869 [Multi-domain] Cd Length: 143 Bit Score: 127.79 E-value: 2.82e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 90 DRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIEEVK 169
Cdd:smart00866 1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128705 170 KMVI---DRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
Cdd:smart00866 81 GLKIvrsTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
5-70 |
2.33e-28 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 102.14 E-value: 2.33e-28
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16128705 5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVK 70
Cdd:cd07377 1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09764 |
PRK09764 |
GntR family transcriptional regulator; |
1-240 |
1.60e-167 |
|
GntR family transcriptional regulator;
Pssm-ID: 182065 [Multi-domain] Cd Length: 240 Bit Score: 461.60 E-value: 1.60e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80
Cdd:PRK09764 1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 81 LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS 160
Cdd:PRK09764 81 LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR 240
Cdd:PRK09764 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR 240
|
|
| MngR |
COG2188 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
1-237 |
2.28e-84 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 250.93 E-value: 2.28e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80
Cdd:COG2188 1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 81 LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVME-N 159
Cdd:COG2188 81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLEtG 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128705 160 SKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRK 237
Cdd:COG2188 161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
|
|
| UTRA |
pfam07702 |
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ... |
90-229 |
6.07e-39 |
|
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 429607 [Multi-domain] Cd Length: 141 Bit Score: 131.95 E-value: 6.07e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 90 DRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMEN-SKYHFIEEV 168
Cdd:pfam07702 1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEER 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16128705 169 KKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
Cdd:pfam07702 81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
|
|
| trehalos_R_Bsub |
TIGR02404 |
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ... |
7-236 |
6.57e-38 |
|
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]
Pssm-ID: 274116 [Multi-domain] Cd Length: 233 Bit Score: 132.10 E-value: 6.57e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 7 YRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV-KEERVNYDIFQLTSFD 85
Cdd:TIGR02404 2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSFK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 86 EKLSDRHVDTHSEVLIFEV-IPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHF 164
Cdd:TIGR02404 82 ELNETLGLDSKTEVVELDKeDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQY 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128705 165 IEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQR 236
Cdd:TIGR02404 162 LENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
|
|
| UTRA |
smart00866 |
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ... |
90-229 |
2.82e-37 |
|
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.
Pssm-ID: 214869 [Multi-domain] Cd Length: 143 Bit Score: 127.79 E-value: 2.82e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 90 DRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIEEVK 169
Cdd:smart00866 1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128705 170 KMVI---DRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
Cdd:smart00866 81 GLKIvrsTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
|
|
| PRK11402 |
PRK11402 |
transcriptional regulator PhoB; |
3-236 |
1.06e-33 |
|
transcriptional regulator PhoB;
Pssm-ID: 183118 [Multi-domain] Cd Length: 241 Bit Score: 121.48 E-value: 1.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLT 82
Cdd:PRK11402 7 HQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 83 SFDEKLSDRHVDTHSEVLIFEvIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMEN-SK 161
Cdd:PRK11402 87 GFTDFGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsST 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16128705 162 YHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQR 236
Cdd:PRK11402 166 YQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTIDNKR 240
|
|
| C_P_lyase_phnF |
TIGR02325 |
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ... |
6-232 |
3.26e-33 |
|
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]
Pssm-ID: 131378 [Multi-domain] Cd Length: 238 Bit Score: 120.27 E-value: 3.26e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFD 85
Cdd:TIGR02325 9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 86 EKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYH-F 164
Cdd:TIGR02325 89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASGSITdA 168
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128705 165 IEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTL 232
Cdd:TIGR02325 169 LREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTM 236
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
5-70 |
2.33e-28 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 102.14 E-value: 2.33e-28
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16128705 5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVK 70
Cdd:cd07377 1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
|
|
| FadR |
COG2186 |
DNA-binding transcriptional regulator, FadR family [Transcription]; |
1-71 |
1.28e-25 |
|
DNA-binding transcriptional regulator, FadR family [Transcription];
Pssm-ID: 441789 [Multi-domain] Cd Length: 232 Bit Score: 100.01 E-value: 1.28e-25
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16128705 1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE 71
Cdd:COG2186 3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRE 73
|
|
| PRK14999 |
PRK14999 |
histidine utilization repressor; Provisional |
5-230 |
3.16e-24 |
|
histidine utilization repressor; Provisional
Pssm-ID: 184961 [Multi-domain] Cd Length: 241 Bit Score: 96.54 E-value: 3.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSF 84
Cdd:PRK14999 12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 85 DEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWMPLALFPD-LTWQVMENSKYH 163
Cdd:PRK14999 92 AEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDyLTQDYRQTTPHA 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128705 164 FIEEVKKMVidRSEQEIIPLMPTEEMSRLLNISQTKPILeKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
Cdd:PRK14999 172 YLSRIAPLT--EGEHIVEAVRATAQECAWLTIKEHEPCL-LIRRTTWSASRIVSHARLLFPGSRYRL 235
|
|
| GntR |
pfam00392 |
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
6-69 |
1.56e-23 |
|
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.
Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 89.60 E-value: 1.56e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16128705 6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
Cdd:pfam00392 1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
|
|
| ARO8 |
COG1167 |
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ... |
2-73 |
2.62e-23 |
|
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis
Pssm-ID: 440781 [Multi-domain] Cd Length: 471 Bit Score: 97.59 E-value: 2.62e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128705 2 GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEER 73
Cdd:COG1167 9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80
|
|
| YhcF |
COG1725 |
DNA-binding transcriptional regulator YhcF, GntR family [Transcription]; |
4-71 |
7.38e-23 |
|
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
Pssm-ID: 441331 [Multi-domain] Cd Length: 114 Bit Score: 89.47 E-value: 7.38e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128705 4 KPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE 71
Cdd:COG1725 9 VPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
|
|
| HTH_GNTR |
smart00345 |
helix_turn_helix gluconate operon transcriptional repressor; |
10-69 |
5.23e-21 |
|
helix_turn_helix gluconate operon transcriptional repressor;
Pssm-ID: 197669 [Multi-domain] Cd Length: 60 Bit Score: 83.01 E-value: 5.23e-21
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 10 IADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
Cdd:smart00345 1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
|
|
| GntR |
COG1802 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
3-71 |
6.24e-16 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441407 [Multi-domain] Cd Length: 222 Bit Score: 73.80 E-value: 6.24e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128705 3 HKPLYRQIADRIREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE 71
Cdd:COG1802 9 RESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
|
|
| PRK10079 |
PRK10079 |
phosphonate metabolism transcriptional regulator PhnF; Provisional |
6-232 |
7.25e-15 |
|
phosphonate metabolism transcriptional regulator PhnF; Provisional
Pssm-ID: 182227 [Multi-domain] Cd Length: 241 Bit Score: 71.34 E-value: 7.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 6 LYRQIADRIrEQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFD 85
Cdd:PRK10079 13 RYQEIAAKL-EQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128705 86 EKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITPQDRVWHVKRVRYRKQKPMALEETWmplalFPDLTW-----QVMENS 160
Cdd:PRK10079 92 QNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHY-----FADLTWwptlqRFDSGS 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128705 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVD-GRVFEYSRNAFNTDDYKFTL 232
Cdd:PRK10079 167 LHDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTLNHRDGeSSPAEYSVSLTRADMIEFTM 239
|
|
| PRK10421 |
PRK10421 |
DNA-binding transcriptional repressor LldR; Provisional |
4-72 |
1.88e-14 |
|
DNA-binding transcriptional repressor LldR; Provisional
Pssm-ID: 236690 [Multi-domain] Cd Length: 253 Bit Score: 70.57 E-value: 1.88e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128705 4 KPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEE 72
Cdd:PRK10421 1 RRLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWR 69
|
|
| PRK09990 |
PRK09990 |
DNA-binding transcriptional regulator GlcC; Provisional |
8-69 |
1.08e-09 |
|
DNA-binding transcriptional regulator GlcC; Provisional
Pssm-ID: 182186 [Multi-domain] Cd Length: 251 Bit Score: 57.08 E-value: 1.08e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16128705 8 RQIADRIREQIAR----GELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
Cdd:PRK09990 6 RPIADVVAERIERlivdGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFV 71
|
|
| pdhR |
PRK09464 |
pyruvate dehydrogenase complex transcriptional repressor PdhR; |
9-72 |
6.26e-08 |
|
pyruvate dehydrogenase complex transcriptional repressor PdhR;
Pssm-ID: 181879 [Multi-domain] Cd Length: 254 Bit Score: 51.95 E-value: 6.26e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128705 9 QIADRIREQ----IARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEE 72
Cdd:PRK09464 10 KLSDVIEQQleflILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
|
|
| PRK03837 |
PRK03837 |
transcriptional regulator NanR; Provisional |
4-53 |
3.10e-07 |
|
transcriptional regulator NanR; Provisional
Pssm-ID: 235166 [Multi-domain] Cd Length: 241 Bit Score: 49.64 E-value: 3.10e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 16128705 4 KPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQL 53
Cdd:PRK03837 12 KKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQAL 61
|
|
| PRK15481 |
PRK15481 |
transcriptional regulatory protein PtsJ; Provisional |
9-71 |
6.72e-07 |
|
transcriptional regulatory protein PtsJ; Provisional
Pssm-ID: 185378 [Multi-domain] Cd Length: 431 Bit Score: 49.27 E-value: 6.72e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128705 9 QIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE 71
Cdd:PRK15481 9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRG 71
|
|
| PRK10225 |
PRK10225 |
Uxu operon transcriptional regulator; |
7-78 |
1.02e-06 |
|
Uxu operon transcriptional regulator;
Pssm-ID: 182318 [Multi-domain] Cd Length: 257 Bit Score: 48.48 E-value: 1.02e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128705 7 YRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDI 78
Cdd:PRK10225 11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNT 82
|
|
| PRK11523 |
PRK11523 |
transcriptional regulator ExuR; |
6-69 |
2.31e-05 |
|
transcriptional regulator ExuR;
Pssm-ID: 183176 [Multi-domain] Cd Length: 253 Bit Score: 44.45 E-value: 2.31e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16128705 6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
Cdd:PRK11523 9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
|
|
| PRK11414 |
PRK11414 |
GntR family transcriptional regulator; |
1-59 |
2.37e-03 |
|
GntR family transcriptional regulator;
Pssm-ID: 183126 [Multi-domain] Cd Length: 221 Bit Score: 37.93 E-value: 2.37e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 16128705 1 MGHKPLYRQIADRIREQIARGELKPGDALPTESaLQTEFGVSRVTVRQALRQLVEQQIL 59
Cdd:PRK11414 7 TQHISLTLQVENDLKHQLSIGALKPGARLITKN-LAEQLGMSITPVREALLRLVSVNAL 64
|
|
| |
