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Conserved domains on  [gi|16128714|ref|NP_415267|]
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Tol-Pal system protein TolA [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

cell envelope integrity protein TolA( domain architecture ID 11484310)

cell envelope integrity protein TolA is part of the Tol-Pal system that plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-421 1.79e-92

cell envelope integrity inner membrane protein TolA; Provisional


:

Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 284.01  E-value: 1.79e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714    1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510   1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELkqkqaeeaaakaaadakakaeadakaaeeaa 160
Cdd:PRK09510  81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAAL------------------------------- 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  161 kkaaADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAA 240
Cdd:PRK09510 130 ----KQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEA 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  241 EKAAADKKAAEKAAAEKAAADKKAAAEKAAADKKAAAAKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNAS 320
Cdd:PRK09510 206 EAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTGGGAKGNGAQ 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  321 PAGSGNTKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKI 400
Cdd:PRK09510 286 GAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDASSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKI 365

                        410       420
                 ....*....|....*....|.
gi 16128714  401 PKPPSQAVYEVFKNAPLDFKP 421
Cdd:PRK09510 366 PKPPSQEVYEKFKNAPLDFKP 386
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-421 1.79e-92

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 284.01  E-value: 1.79e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714    1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510   1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELkqkqaeeaaakaaadakakaeadakaaeeaa 160
Cdd:PRK09510  81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAAL------------------------------- 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  161 kkaaADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAA 240
Cdd:PRK09510 130 ----KQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEA 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  241 EKAAADKKAAEKAAAEKAAADKKAAAEKAAADKKAAAAKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNAS 320
Cdd:PRK09510 206 EAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTGGGAKGNGAQ 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  321 PAGSGNTKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKI 400
Cdd:PRK09510 286 GAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDASSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKI 365

                        410       420
                 ....*....|....*....|.
gi 16128714  401 PKPPSQAVYEVFKNAPLDFKP 421
Cdd:PRK09510 366 PKPPSQEVYEKFKNAPLDFKP 386
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 327-419 8.15e-40

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 137.56  E-value: 8.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   327 TKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAA-AKLAKIPKPPS 405
Cdd:pfam06519   1 AAGSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAvAKTAKIPKPPS 80

                          90
                  ....*....|....
gi 16128714   406 QAVYEVFKNAPLDF 419
Cdd:pfam06519  81 QDVYEKFKNINLDF 94
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 12-421 1.30e-33

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 128.81  E-value: 1.30e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714    12 KRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSsIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEE 91
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSLYHSVKPEPGGGAEI-IQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714    92 LREKQAAEQERLKQLeKERLAAQEQKKQAEEAAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKA 171
Cdd:TIGR02794  80 AEKQRAAEQARQKEL-EQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   172 EAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAEKAAADKKAAe 251
Cdd:TIGR02794 159 KAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDI- 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   252 kaaaekaaadkkaaaekaaadkkaaaakaaaekaaaakaaaeaddifGELSSGKNAPKTGGGAKgnnaspagsgntknnG 331
Cdd:TIGR02794 238 -----------------------------------------------FGLASGSNAEKQGGARG---------------A 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   332 ASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALA-AAKLAKIPKPPSQAVYE 410
Cdd:TIGR02794 256 AAGSEVDKYAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDGTLLSVTKSSGDPALCQAALAaVAKAAKLPMPPSDPVYE 335

                         410
                  ....*....|.
gi 16128714   411 VFKNAPLDFKP 421
Cdd:TIGR02794 336 EFKNINLTFKP 346
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
62-128 9.37e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.29  E-value: 9.37e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128714  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:COG4717 153 ERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-421 1.79e-92

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 284.01  E-value: 1.79e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714    1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510   1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELkqkqaeeaaakaaadakakaeadakaaeeaa 160
Cdd:PRK09510  81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAAL------------------------------- 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  161 kkaaADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAA 240
Cdd:PRK09510 130 ----KQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEA 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  241 EKAAADKKAAEKAAAEKAAADKKAAAEKAAADKKAAAAKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNAS 320
Cdd:PRK09510 206 EAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTGGGAKGNGAQ 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  321 PAGSGNTKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKI 400
Cdd:PRK09510 286 GAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDASSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKI 365

                        410       420
                 ....*....|....*....|.
gi 16128714  401 PKPPSQAVYEVFKNAPLDFKP 421
Cdd:PRK09510 366 PKPPSQEVYEKFKNAPLDFKP 386
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 327-419 8.15e-40

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 137.56  E-value: 8.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   327 TKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAA-AKLAKIPKPPS 405
Cdd:pfam06519   1 AAGSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAvAKTAKIPKPPS 80

                          90
                  ....*....|....
gi 16128714   406 QAVYEVFKNAPLDF 419
Cdd:pfam06519  81 QDVYEKFKNINLDF 94
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 12-421 1.30e-33

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 128.81  E-value: 1.30e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714    12 KRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSsIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEE 91
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSLYHSVKPEPGGGAEI-IQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714    92 LREKQAAEQERLKQLeKERLAAQEQKKQAEEAAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKA 171
Cdd:TIGR02794  80 AEKQRAAEQARQKEL-EQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   172 EAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAEKAAADKKAAe 251
Cdd:TIGR02794 159 KAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDI- 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   252 kaaaekaaadkkaaaekaaadkkaaaakaaaekaaaakaaaeaddifGELSSGKNAPKTGGGAKgnnaspagsgntknnG 331
Cdd:TIGR02794 238 -----------------------------------------------FGLASGSNAEKQGGARG---------------A 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714   332 ASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALA-AAKLAKIPKPPSQAVYE 410
Cdd:TIGR02794 256 AAGSEVDKYAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDGTLLSVTKSSGDPALCQAALAaVAKAAKLPMPPSDPVYE 335

                         410
                  ....*....|.
gi 16128714   411 VFKNAPLDFKP 421
Cdd:TIGR02794 336 EFKNINLTFKP 346
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
62-128 9.37e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.29  E-value: 9.37e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128714  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:COG4717 153 ERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 68-129 1.77e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 1.77e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128714  68 QSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:COG1196 297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-128 1.98e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 1.98e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128714  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:COG1196 368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 62-128 2.60e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.93  E-value: 2.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128714    62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELR-EKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:pfam15709 359 EQRRLQQEQLERAEKMREELELEQQRRFEEIRlRKQRLEEERQRQEEEERKQRLQLQAAQERARQQQE 426
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 62-127 3.91e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.55  E-value: 3.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16128714    62 EQYKRMQSQESSAKRSDEQRKMKE---QQAAEELREKQAAEQERLKQL-------EKERLAAQEQKKQAEEAAKQA 127
Cdd:pfam15709 433 QELQRKKQQEEAERAEAEKQRQKElemQLAEEQKRLMEMAEEERLEYQrqkqeaeEKARLEAEERRQKEEEAARLA 508
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 76-127 4.22e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 39.09  E-value: 4.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16128714    76 RSDEQ---RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAE-EAAKQA 127
Cdd:pfam07946 266 REEEIekiKKAAEEERAEEAQEKKEEAKKKEREEKLAKLSPEEQRKYEEkERKKEQ 321
PTZ00121 PTZ00121
MAEBL; Provisional
 61-128 4.27e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 4.27e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16128714    61 VEQYKRMQSQESSAKRSDEQ-RKMKEQQAAEELREK--QAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:PTZ00121 1430 KKKADEAKKKAEEAKKADEAkKKAEEAKKAEEAKKKaeEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAD 1500
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 60-127 6.13e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 39.16  E-value: 6.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128714    60 VVEQYKRMQSQESSAKRSDEQRKMKEQQAAEeLREKQAAEQERLKQLEKERLAA-QEQKKQAEEAAKQA 127
Cdd:PRK11448  158 LELQAREKAQSQALAEAQQQELVALEGLAAE-LEEKQQELEAQLEQLQEKAAETsQERKQKRKEITDQA 225
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 78-126 8.47e-03

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 38.00  E-value: 8.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 16128714    78 DEQRKMKEQQAA-EELREKQAAEQERL------KQLEKERLAAQ--EQKKQAEEAAKQ 126
Cdd:pfam06098 153 EELANLREQQRAfEELRNAELAEVQRLeeqerrLREEKERRIAQqrEALKKEKETAEK 210
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-128 9.11e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.38  E-value: 9.11e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714  62 EQYKRMQSQESSAKRSD---EQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:COG1196 281 LELEEAQAEEYELLAELarlEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE 350
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 63-129 9.18e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 38.39  E-value: 9.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128714    63 QYKRMQSQESSAKRSDEQRKMKEQQAAEE---------------LREKQAAEQERLKQLEKERLAAQEQKKQA-EEAAKQ 126
Cdd:pfam15709 436 QRKKQQEEAERAEAEKQRQKELEMQLAEEqkrlmemaeeerleyQRQKQEAEEKARLEAEERRQKEEEAARLAlEEAMKQ 515


                  ...
gi 16128714   127 AEL 129
Cdd:pfam15709 516 AQE 518
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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