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Conserved domains on  [gi|16128725|ref|NP_415278|]
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galactokinase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

galactokinase( domain architecture ID 11480374)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  3.30.230.10|3.30.70.890
EC:  2.7.1.6
Gene Ontology:  GO:0046835|GO:0006012|GO:0005534|GO:0004335|GO:0005524
PubMed:  15526155|26862196
SCOP:  4000959|4001389

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05101 PRK05101
galactokinase; Provisional
 1-382 0e+00

galactokinase; Provisional


:

Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 819.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725    1 MSLKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSL 80
Cdd:PRK05101   1 MSLKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDNQQDEFSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   81 DAPIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQE 160
Cdd:PRK05101  81 DAPIVPHPEQQWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  161 AENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP 240
Cdd:PRK05101 161 AENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRGLVDSEYNTRRQQCETAARFFGVK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  241 ALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK 320
Cdd:PRK05101 241 ALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128725  321 AVIGDKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC 382
Cdd:PRK05101 321 AVIGDQGGVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQC 382
 
Name Accession Description Interval E-value
PRK05101 PRK05101
galactokinase; Provisional
 1-382 0e+00

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 819.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725    1 MSLKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSL 80
Cdd:PRK05101   1 MSLKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDNQQDEFSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   81 DAPIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQE 160
Cdd:PRK05101  81 DAPIVPHPEQQWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  161 AENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP 240
Cdd:PRK05101 161 AENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRGLVDSEYNTRRQQCETAARFFGVK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  241 ALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK 320
Cdd:PRK05101 241 ALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128725  321 AVIGDKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC 382
Cdd:PRK05101 321 AVIGDQGGVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 4-382 0e+00

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 639.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725     4 KEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSLDAP 83
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERSLDLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725    84 IVAHENYQWANYVRGVVKHLQLRNNSFG-GVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAE 162
Cdd:TIGR00131  81 LDGSEVSDWANYFKGVLHVAQERFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   163 NQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPK-GVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP- 240
Cdd:TIGR00131 161 NHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQlGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAATd 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   241 --ALRDVTIEEFN---AVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTL 315
Cdd:TIGR00131 241 kgALRDFMNEYFAryiARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDEL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128725   316 VEIVKAVIGdKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC 382
Cdd:TIGR00131 321 VCSAALVNG-SGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGSC 386
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
3-382 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 592.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   3 LKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQlDEFSLDa 82
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEE-VEFDLD- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  83 PIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAE 162
Cdd:COG0153  79 DLEPGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAE 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725 163 NQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMP-KGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPA 241
Cdd:COG0153 159 NEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKS 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725 242 LRDVTIEEFNAVAHEL-DPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK 320
Cdd:COG0153 239 LRDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELAL 318

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128725 321 AVIGDkGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC 382
Cdd:COG0153 319 AEAGV-LGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 9-58 3.61e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 85.58  E-value: 3.61e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 16128725     9 SLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAP 58
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PRK05101 PRK05101
galactokinase; Provisional
 1-382 0e+00

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 819.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725    1 MSLKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSL 80
Cdd:PRK05101   1 MSLKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDNQQDEFSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   81 DAPIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQE 160
Cdd:PRK05101  81 DAPIVPHPEQQWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  161 AENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP 240
Cdd:PRK05101 161 AENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRGLVDSEYNTRRQQCETAARFFGVK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  241 ALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK 320
Cdd:PRK05101 241 ALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128725  321 AVIGDKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC 382
Cdd:PRK05101 321 AVIGDQGGVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 4-382 0e+00

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 639.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725     4 KEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSLDAP 83
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERSLDLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725    84 IVAHENYQWANYVRGVVKHLQLRNNSFG-GVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAE 162
Cdd:TIGR00131  81 LDGSEVSDWANYFKGVLHVAQERFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   163 NQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPK-GVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP- 240
Cdd:TIGR00131 161 NHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQlGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAATd 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   241 --ALRDVTIEEFN---AVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTL 315
Cdd:TIGR00131 241 kgALRDFMNEYFAryiARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDEL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128725   316 VEIVKAVIGdKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC 382
Cdd:TIGR00131 321 VCSAALVNG-SGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGSC 386
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
3-382 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 592.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   3 LKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQlDEFSLDa 82
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEE-VEFDLD- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  83 PIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAE 162
Cdd:COG0153  79 DLEPGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAE 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725 163 NQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMP-KGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPA 241
Cdd:COG0153 159 NEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKS 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725 242 LRDVTIEEFNAVAHEL-DPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK 320
Cdd:COG0153 239 LRDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELAL 318

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128725 321 AVIGDkGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC 382
Cdd:COG0153 319 AEAGV-LGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
PRK05322 PRK05322
galactokinase; Provisional
 2-379 2.52e-138

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 399.23  E-value: 2.52e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725    2 SLKEKtqslFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLD-EFSL 80
Cdd:PRK05322   5 ELKKK----FAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGIiEFDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   81 DApIVAHENYQWANYVRGVVKHLQLRNNSF-GGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQ 159
Cdd:PRK05322  81 DD-LSFDKEDDWANYPKGVLKFLQEAGYKIdHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  160 EAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVsmP---KGVAVVIINSNFKRTLVGSEYNTRREQCETGARF 236
Cdd:PRK05322 160 KTENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYV--PldlGDYVIVIMNTNKRRELADSKYNERRAECEKALEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  237 FQQ----PALRDVTIEEFNAVAHEL-DPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQ 311
Cdd:PRK05322 238 LQKkldiKSLGELTEEEFDEYSYLIkDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLE 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16128725  312 IDTLVEI---VKAVIgdkgGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGA 379
Cdd:PRK05322 318 LDTLVEAawkQEGVL----GARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGA 384
PRK03817 PRK03817
galactokinase; Provisional
 22-382 4.13e-114

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 336.58  E-value: 4.13e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   22 TIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPrdDRKVRVMAaDYENQLDEFSLDApiVAHENyQWANYVRGVVK 101
Cdd:PRK03817   2 KVKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEK--SEKFIFYS-ENFNEEKTFELDK--LEKLN-SWADYIKGVIW 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  102 HLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALG 181
Cdd:PRK03817  76 VLEKRGYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  182 KKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPALRDVTIEEFnavaHELDPIV 261
Cdd:PRK03817 156 KKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEDL----SKLPPLL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  262 AKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKavigDKG--GVRMTGGGFGGC 339
Cdd:PRK03817 232 RKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFAL----ELGayGARLTGAGFGGS 307

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 16128725  340 IVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC 382
Cdd:PRK03817 308 AIALVDKGKFESIGEELLEEYKKRFGIDPKYFVVESSDGVRKI 350
PRK00555 PRK00555
galactokinase; Provisional
 25-382 5.31e-92

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 280.59  E-value: 5.31e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   25 APGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVmAADYENQLDEFSLDApiVAHENYQWANYVRGVVKHLQ 104
Cdd:PRK00555   7 APGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITA-SSDRADGSARIPLDT--TPGQVTGWAAYAAGVIWALR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  105 LRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALGKKD 184
Cdd:PRK00555  84 GAGHPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENEYVGAPTGLLDQLAALFGAPK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  185 HALLIDCRSLGTKAVSM---PKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPALRDVTIEEFNAVAHELDPIV 261
Cdd:PRK00555 164 TALLIDFRDLTVRPVAFdpdAAGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRGLAALGAIADPID 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  262 AKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEivKAVIGDKGGVRMTGGGFGGCIV 341
Cdd:PRK00555 244 ARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIAD--SAVRAGALGARMTGGGFGGCVI 321

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 16128725  342 ALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC 382
Cdd:PRK00555 322 ALVPADRAEDVADTVRRAAVTAGYPEPAVSRTYAAPGAGEC 362
PLN02521 PLN02521
galactokinase
 11-379 1.04e-52

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 182.21  E-value: 1.04e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   11 FANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRD-DRKVRVMAADYENQLDEFSLD-APIVAHE 88
Cdd:PLN02521  39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEgSKKLRIANVNDKYTTCTFPADpDQEVDLA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   89 NYQWANYV----RGVVKHLQLRNNSFG---GVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEA 161
Cdd:PLN02521 119 NHKWGNYFicgyKGVFEFLKSKGVDVGppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKC 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  162 EnQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINS---NFKRTLVGSEYNTRREQCETGARFF- 237
Cdd:PLN02521 199 E-RHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSlaeSNKAVTAATNYNNRVVECRLAAIVLa 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  238 ------QQPA------LRDV-----------------------------TIEEFNAV-AHELDPIVA------------- 262
Cdd:PLN02521 278 vklgmsAEEAiskvktLSDVeglcvsfagshgssdpavavkellhegpyTAEEIEEIlGESLTSIFKnsptslavlkaak 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  263 -----KRVRHILTENAR-----TVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAviGDKGGVRMT 332
Cdd:PLN02521 358 hfklhQRAVHVYSEAKRvhafrDTVSSSLSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRD--NGALGARLT 435

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 16128725  333 GGGFGGCIVALIPEELVPAVQQAVAEQYE---------AKTGIKETFYVCKPSQGA 379
Cdd:PLN02521 436 GAGWGGCAVALVKEAIVPQFILALKEKFYksriekgviKEEDLGLYVFASKPSSGA 491
PTZ00290 PTZ00290
galactokinase; Provisional
 25-379 3.14e-45

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 161.91  E-value: 3.14e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   25 APGRVNLIGEHTDYNDGFVLPCAIDYQTVI---SCAPRDDRKVRVMAADYENqldeFSLDAPIVAHENYQWANYVRGVVk 101
Cdd:PTZ00290  42 APGRVNFIGEHVDYMGGYVCPAAVLEGCHIlvgRVKHFCDHKLRFATETDEH----FVLDHLGGAKHNKAWTTFVRGAA- 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  102 hlQLRNNSFG---------GVDMVISGNVPQGAGLSSSASLEV----AVGTVLQQLYH------------LPLDGAQ--- 153
Cdd:PTZ00290 117 --TLRLNRLGvaidapslqGVCMVVHGTLPMGAGMSASASFGVallnAINTVVTRRYKgcptspgrrysiLPPMSKEeli 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  154 -IALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMP----KGVAVVIINSNFKRTLVGSE---YNT 225
Cdd:PTZ00290 195 eLAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHDMTpllgDGACFLLIDSMIKHDLLGGTagmYNT 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  226 RREQCETGARFFQQPALR--------------------DVT--IEEFNAvahELDPIVAKRVRHILTENARTVE------ 277
Cdd:PTZ00290 275 VRSDQEGAQKKIGKHRYRgkpftfsdlvrnpkkytfdgDVVafMESCKP---LMTPGEFERGTYNIMEQIRTLEfiklnd 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  278 AASALEQGD-LKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVIGDKGGvRMTGGGFGGCIVALIPEELVPAVQQAV 356
Cdd:PTZ00290 352 PELPLSREErFRKAGEILNAGHQGMRDLMKITTPELDFIHELINEEKGVAGG-RMMGGGFGGCIILLLKKNAVDRVVAHV 430

                        410       420
                 ....*....|....*....|...
gi 16128725  357 AEQYEAKTGIKETFYVCKPSQGA 379
Cdd:PTZ00290 431 REKFKARFGVENDVYPVVAGDGA 453
PLN02865 PLN02865
galactokinase
 25-361 1.79e-41

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 150.72  E-value: 1.79e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   25 APGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQ----LDEFSLDAPIVAH---ENYQWANYVR 97
Cdd:PLN02865  35 SPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEGEvrfrVDEIQHPIANVSSdskEESNWGDYAR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   98 GVVKHLQLRNNSF-GGVDMVISG-NVPQGAGLSSSASLEVAVGTVLQQLYHL---PLDGAQIAlngQEAENQFVGCNCGI 172
Cdd:PLN02865 115 GAVYALQSRGHALsQGITGYISGsEGLDSSGLSSSAAVGVAYLLALENANNLtvsPEDNIELD---RLIENEYLGLRNGI 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  173 MDQLISALGKKDHALLIDCRSLGTKAVSMP-------KGVAVVIINSNFKRTLVGSE-YNTRREQCETGARFF------- 237
Cdd:PLN02865 192 LDQSAILLSRYGCLTFMDCKTLDHKLVSLQfqqpggeKPFKILLAFSGLRHALTNKPgYNLRVSECQEAARFLleasgnd 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  238 -QQPALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLV 316
Cdd:PLN02865 272 eLEPLLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLY 351

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 16128725  317 EIVKAVIGDKGGvRMTGGGFGGCIVALIPEELVPAVQQAVAEQYE 361
Cdd:PLN02865 352 EILLKAPGVYGA-RFSGAGFRGCCVAFVDAEMAEEAASFVRDEYE 395
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 25-343 2.71e-30

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 117.25  E-value: 2.71e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  25 APGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSLDAPIVAhenyqwanYVRGVVKH-L 103
Cdd:COG1577   1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGTLDLDPLADAALR--------YIKAAIEAaL 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725 104 QLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGcNCGIMDQLISALGkk 183
Cdd:COG1577  73 EYLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHG-NPSGLDTAASTYG-- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725 184 dHALLIDcRSLGTKAVSMPKGVAVVIINSnfkrtlvGSEYNTRreqcetgarffqqPALRDVtieefnAVAHELDPivaK 263
Cdd:COG1577 150 -GPIYYQ-RGDRAEPLELPKNLPLVVGDT-------GVPASTK-------------ELVAKV------RKLKERNP---E 198

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725 264 RVRHILTENARTVEAA-SALEQGDLKRMGELMAESHAsMRDDFEITVPQIDTLVEIVKAViGDKGGvRMTGGGFGGCIVA 342
Cdd:COG1577 199 LYEAFLEEIGDLVEEAiEALEEGDLEALGELMNENHG-LLRALGVSTPELDRLVEAARKA-GALGA-KLTGAGGGGCVIA 275


                .
gi 16128725 343 L 343
Cdd:COG1577 276 L 276
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 9-58 3.61e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 85.58  E-value: 3.61e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 16128725     9 SLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAP 58
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 25-343 5.32e-19

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 85.81  E-value: 5.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725    25 APGRVNLIGEHtdyndgFV------LPCAID-YQTVISCAPRDDRKVRVMAadYENQLDEFSldapivahENYQWANYVR 97
Cdd:TIGR00549   1 APGKIILFGEH------AVvygepaIAAPIPlRTTVTVIESSDGSFIESDL--GRGSLDDAP--------DELDGLKYVL 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725    98 GVVKHLQLRNNSFgGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGImDQLI 177
Cdd:TIGR00549  65 AEFLSRFSELNPP-PLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTAT 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   178 SALGkkdHALLIdCRSLGTKAVSMPKGVAVVIINSNFKRtlvgseyNTRReqcetgarffqqpalrdvtieefnAVAhel 257
Cdd:TIGR00549 143 STSG---GPVYF-EKGEGEFTKLISLDGYFVIADTGVSG-------STKE------------------------AVA--- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   258 dpivakRVRHILTENARTV------------EAASALEQGDLKRMGELMAESHASMrDDFEITVPQIDTLVEivkavIGD 325
Cdd:TIGR00549 185 ------RVRQLLERFPELIdsimdaigeltlEAKAALQDGDVESLGELMNINQGLL-KALGVSHPKLDQLVE-----IAR 252

                         330       340
                  ....*....|....*....|.
gi 16128725   326 KGGV---RMTGGGFGGCIVAL 343
Cdd:TIGR00549 253 KAGAlgaKLTGAGGGGCMIAL 273
PRK03926 PRK03926
mevalonate kinase; Provisional
 25-357 1.79e-15

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 76.25  E-value: 1.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   25 APGRVNLIGEHTDYNDGFVLPCAIDYQTviscaprddrKVRVmaadyenqldEFSLDApIVAHENYQWA----NYVRGVV 100
Cdd:PRK03926   6 APGKIYLFGEHAVVYGKPAIACAIDLRT----------YVRA----------EFNDDS-IYIESDYGKTgekhPYVSAAI 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  101 KHLQlRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGImDQLISAL 180
Cdd:PRK03926  65 EKMR-EEADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DTYVSTM 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  181 G------KKDHALLIDCrslgtkavsmpkgvAVVIINSN-FKRT--LVGseyNTRReqcetgarffqqpaLRdvtiEEFN 251
Cdd:PRK03926 143 GgfvtipDRKKLPFPEC--------------GIVVGYTGsSGSTkeLVA---NVRK--------------LK----EEYP 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  252 AVaheLDPivakrvrhILTENARTVEAA-SALEQGDLKRMGELMAESHAsMRDDFEITVPQIDTLVEIVKAvigdKG--G 328
Cdd:PRK03926 188 EL---IEP--------ILSSIGKISEKGeELILSGDYVSLGELMNINQG-LLDALGVSTKELSELIYAART----AGalG 251

                        330       340
                 ....*....|....*....|....*....
gi 16128725  329 VRMTGGGFGGCIVALIPEELVPAVQQAVA 357
Cdd:PRK03926 252 AKITGAGGGGCMVALAAPEKQSEVATAIK 280
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 114-182 3.89e-15

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 69.50  E-value: 3.89e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128725   114 DMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLdgaqiALNGQEAENQFVGCNCGIMDQLISALGK 182
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPL-----AKLALEAEELAGGGRGGGMDVAASLYGG 64
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 278-362 7.82e-12

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 60.95  E-value: 7.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   278 AASALEQGDLKRMGELMAESHASM--RDDFEITVPQIDTLVEIVKAVIGdkgGVRMTGGGFGGCIVALIP-EELVPAVQQ 354
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL---GAKLSGSGGGPTVFALFKdEDDAEEVAR 77


                  ....*...
gi 16128725   355 AVAEQYEA 362
Cdd:pfam08544  78 ALREAGKK 85
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 99-343 5.01e-08

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 54.09  E-value: 5.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725   99 VVKHLQLrNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGImDQLIS 178
Cdd:PTZ00298  82 VLRHLNI-DTSVDGLKMHLGGPLVPSSGIGASASDVVSLSRALSELYQLNLTEEEVNLSAFVGEGGYHGTPSGA-DNTAA 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  179 ALGkkdhALLIDCRSLGT---KAVSMPKGVAVVIINS--NFKRTLVGSEYNTRREQcetgarffqQPALRDVTIEEFNAV 253
Cdd:PTZ00298 160 TYG----GLISYRRVNGKsvfKRIAFQQPLYLVVCSTgiTASTTKVVGDVRKLKEN---------QPTWFNRLLENYNAC 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  254 AHEldpivakrvrhiltenartveAASALEQGDLKRMGELMAESHASMRddfEITV--PQIDTLVEIVKAVigDKGGVRM 331
Cdd:PTZ00298 227 VSE---------------------AKEALQKGNLFRVGELMNANHDLCQ---KLTVscRELDSIVQTCRTY--GALGAKM 280

                        250
                 ....*....|..
gi 16128725  332 TGGGFGGCIVAL 343
Cdd:PTZ00298 281 SGTGRGGLVVAL 292
PLN02677 PLN02677
mevalonate kinase
 116-363 1.80e-05

mevalonate kinase


Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 46.36  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  116 VISGNVPQGAGLSSSASLEVAVGTVL-----------QQLYHLPLDGAQIALNGQ---EAENQFVGCNCGImDQLISALG 181
Cdd:PLN02677 133 VVTSELPLGSGLGSSAAFCVALSAALlaasdsisvstGGNGWSSLDETDLELVNKwafEGEKIIHGKPSGI-DNTVSTYG 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  182 KkdhalLIDCRS--LGTKAVSMPkgVAVVIINsnfkrTLVGSeyNTRREQCETGARFFQQPALRDVTIEEFNAVAHELDP 259
Cdd:PLN02677 212 N-----MIKFKSgeLTRLQSNMP--LKMLITN-----TRVGR--NTKALVAGVSERALRHPDAMKSVFNAVDSISEELAT 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128725  260 IV---AKRVRHIlTENARTVEAASALEQGDLKRMGElmaeSHASMRddfeiTVPQIDTLVEIVKavigdkggvRMTGGGF 336
Cdd:PLN02677 278 IIqspAEDELSI-TEKEEKLKELMEMNQGLLQCMGV----SHSSIE-----TVLRTTLKYKLVS---------KLTGAGG 338

                        250       260
                 ....*....|....*....|....*..
gi 16128725  337 GGCIVALIPEELVPAVQQAVAEQYEAK 363
Cdd:PLN02677 339 GGCVLTLLPTLLSGTVVDKVIAELESS 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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