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Conserved domains on  [gi|90111187|ref|NP_415433|]
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metallo-beta-lactamase superfamily inner membrane protein YcaI [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

ComEC family DNA internalization-related competence protein( domain architecture ID 11485387)

ComEC family DNA internalization-related competence protein similar to Bacillus subtilis ComE operon protein 3, which is required for DNA internalization; the comE operon is required for the binding and uptake of transforming DNA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK11539 PRK11539
ComEC family competence protein; Provisional
1-753 0e+00

ComEC family competence protein; Provisional


:

Pssm-ID: 236924 [Multi-domain]  Cd Length: 755  Bit Score: 1231.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    1 MKITTVGVCIISGIFPLLILPQLPGTLTLAFLTLFACVLAFIPVKTVRYIALTLLFFVWGILSAKQILWAGETLTGATQD 80
Cdd:PRK11539   1 MSITTVAVAIICGILPLLILPQLPGTWILAFLLLLACLLAFIPVKYCRYIALTLLFFLWGILAAKQILWQGETLTQATQD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   81 AIVEITATDGMTTHYGQ----ITHLQGRRIFPASGLVMYGEYLPQAVCAGQQWSMKLKVRAVHGQLNDGGFDSQRYAIAQ 156
Cdd:PRK11539  81 AIVEITATDGMTTHYGQvvirITHLNGKRIFPALGVVLYGEYLPQAVCAGQRWAMKLKVRAVHGQLNEGGFDSQRYAIAQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  157 HQPLTGRFLQASVIEPNCSLRAQYLASLQTTLQPYPWNAVILGLGMGERLSVPKEIKNIMRDTGTAHLMAISGLHIAFAA 236
Cdd:PRK11539 161 RQPLTGRFLQAKVIDPNCSLRQQYLASLEQTLQPYPWRAIILALAFGERLSVPKEIKNLLRDTGTAHLMAISGLHIAFAA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  237 LLAAGLIRSGQIFLPGRWIHWQIPLIGGICCAAFYAWLTGMQPPALRTMVALATWGMLKLSGRQWSGWDVWICCLAAILL 316
Cdd:PRK11539 241 LLGWGLARGGQFFLPVRWIGWQFPLLGGWLCAAFYAWLAGMQPPALRTVLALTLWGLLRLSGRQCSGWQVWLWCLALILL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  317 MDPVAILSQSLWLSAAAVAALIFWYQWFPCPEWQLPPVLRAVVSLIHLQLGITLLLMPVQIVIFHGISLTSFIANLLAIP 396
Cdd:PRK11539 321 SDPLAVLSDSFWLSALAVAALIFWYQWFPLPEWFLPGWLRAVLRLLHLQLGITLLLMPLQILLFHGISLTSLPANLWAVP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  397 LVTFITVPLILAAMVVHLSGPLilEQGLWFLADRSLALLFWGLKSLPEGWINIAECWQWLSFSPWFLLVVWRLNAWRTLP 476
Cdd:PRK11539 401 LVSFITVPLILLALVLHLLPPL--EQGLWFLADRSLALVFWPLKSLPEGWINIGERWQWLSFSGWLALIIWRFNWWRSYP 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  477 AMCVAGGLLMCWPLWQKPRPDEWQLYMLDVGQGLAMVIARNGKAILYDTGLAWPEGDSGQQLIIPWLHWHNLEPEGVILS 556
Cdd:PRK11539 479 AMCVAVLLLMCWPLWQRPREYEWRVDMLDVGHGLAVVIERNGKAILYDTGNAWPTGDSAQQVIIPWLRWHGLTPEGIILS 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  557 HEHLDHRGGLDSILHIWPMLWIRSPLNWEHHQPCVRGEAWQWQGLRFSAHWPLQGSNDKGNNHSCVVKVDDGTNSILLTG 636
Cdd:PRK11539 559 HEHLDHRGGLASLLHAWPMAWIRSPLNWANHLPCVRGEQWQWQGLTFSVHWPLEQSNDAGNNDSCVIRVDDGKHSILLTG 638
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  637 DIEAPAEQKMLSRYWQQVQATLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWRLPSNKVKHRYQLQGYQWIDTPH 716
Cdd:PRK11539 639 DLEAQAEQKLLSRYWQQLAATLLQVPHHGSNTSSSLPFIRAVNGKVALASASRYNAWRLPSVKVKQRYQQQGYQWRDTPH 718
                        730       740       750
                 ....*....|....*....|....*....|....*..
gi 90111187  717 QGQTTVNFSAQGWRISSLREQILPRWYHQWFGVPVDN 753
Cdd:PRK11539 719 SGQLSVYFSADGWRISGYREQILPRWYHQWFGVPVDN 755
 
Name Accession Description Interval E-value
PRK11539 PRK11539
ComEC family competence protein; Provisional
1-753 0e+00

ComEC family competence protein; Provisional


Pssm-ID: 236924 [Multi-domain]  Cd Length: 755  Bit Score: 1231.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    1 MKITTVGVCIISGIFPLLILPQLPGTLTLAFLTLFACVLAFIPVKTVRYIALTLLFFVWGILSAKQILWAGETLTGATQD 80
Cdd:PRK11539   1 MSITTVAVAIICGILPLLILPQLPGTWILAFLLLLACLLAFIPVKYCRYIALTLLFFLWGILAAKQILWQGETLTQATQD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   81 AIVEITATDGMTTHYGQ----ITHLQGRRIFPASGLVMYGEYLPQAVCAGQQWSMKLKVRAVHGQLNDGGFDSQRYAIAQ 156
Cdd:PRK11539  81 AIVEITATDGMTTHYGQvvirITHLNGKRIFPALGVVLYGEYLPQAVCAGQRWAMKLKVRAVHGQLNEGGFDSQRYAIAQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  157 HQPLTGRFLQASVIEPNCSLRAQYLASLQTTLQPYPWNAVILGLGMGERLSVPKEIKNIMRDTGTAHLMAISGLHIAFAA 236
Cdd:PRK11539 161 RQPLTGRFLQAKVIDPNCSLRQQYLASLEQTLQPYPWRAIILALAFGERLSVPKEIKNLLRDTGTAHLMAISGLHIAFAA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  237 LLAAGLIRSGQIFLPGRWIHWQIPLIGGICCAAFYAWLTGMQPPALRTMVALATWGMLKLSGRQWSGWDVWICCLAAILL 316
Cdd:PRK11539 241 LLGWGLARGGQFFLPVRWIGWQFPLLGGWLCAAFYAWLAGMQPPALRTVLALTLWGLLRLSGRQCSGWQVWLWCLALILL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  317 MDPVAILSQSLWLSAAAVAALIFWYQWFPCPEWQLPPVLRAVVSLIHLQLGITLLLMPVQIVIFHGISLTSFIANLLAIP 396
Cdd:PRK11539 321 SDPLAVLSDSFWLSALAVAALIFWYQWFPLPEWFLPGWLRAVLRLLHLQLGITLLLMPLQILLFHGISLTSLPANLWAVP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  397 LVTFITVPLILAAMVVHLSGPLilEQGLWFLADRSLALLFWGLKSLPEGWINIAECWQWLSFSPWFLLVVWRLNAWRTLP 476
Cdd:PRK11539 401 LVSFITVPLILLALVLHLLPPL--EQGLWFLADRSLALVFWPLKSLPEGWINIGERWQWLSFSGWLALIIWRFNWWRSYP 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  477 AMCVAGGLLMCWPLWQKPRPDEWQLYMLDVGQGLAMVIARNGKAILYDTGLAWPEGDSGQQLIIPWLHWHNLEPEGVILS 556
Cdd:PRK11539 479 AMCVAVLLLMCWPLWQRPREYEWRVDMLDVGHGLAVVIERNGKAILYDTGNAWPTGDSAQQVIIPWLRWHGLTPEGIILS 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  557 HEHLDHRGGLDSILHIWPMLWIRSPLNWEHHQPCVRGEAWQWQGLRFSAHWPLQGSNDKGNNHSCVVKVDDGTNSILLTG 636
Cdd:PRK11539 559 HEHLDHRGGLASLLHAWPMAWIRSPLNWANHLPCVRGEQWQWQGLTFSVHWPLEQSNDAGNNDSCVIRVDDGKHSILLTG 638
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  637 DIEAPAEQKMLSRYWQQVQATLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWRLPSNKVKHRYQLQGYQWIDTPH 716
Cdd:PRK11539 639 DLEAQAEQKLLSRYWQQLAATLLQVPHHGSNTSSSLPFIRAVNGKVALASASRYNAWRLPSVKVKQRYQQQGYQWRDTPH 718
                        730       740       750
                 ....*....|....*....|....*....|....*..
gi 90111187  717 QGQTTVNFSAQGWRISSLREQILPRWYHQWFGVPVDN 753
Cdd:PRK11539 719 SGQLSVYFSADGWRISGYREQILPRWYHQWFGVPVDN 755
ComEC_Rec2 TIGR00361
DNA internalization-related competence protein ComEC/Rec2; Apparant orthologs are found in 5 ...
65-718 0e+00

DNA internalization-related competence protein ComEC/Rec2; Apparant orthologs are found in 5 species so far (Haemophilus influenzae, Escherichia coli, Bacillus subtilis, Neisseria gonorrhoeae, Streptococcus pneumoniae), of which all but E. coli are model systems for the study of competence for natural transformation. This protein is a predicted multiple membrane-spanning protein likely to be involved in DNA internalization. In a large number of bacterial species not known to exhibit competence, this protein is replaced by a half-length N-terminal homolog of unknown function, modelled by the related model ComEC_N-term. The role for this protein in species that are not naturally transformable is unknown. [Cellular processes, DNA transformation]


Pssm-ID: 273036 [Multi-domain]  Cd Length: 662  Bit Score: 1006.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    65 KQILWAGETLTGATQDAIVEITATDGMTTHYGQITHLQGRRIFPASGLVMYGEYLPQAVCAGQQWSMKLKVRAVHGQLND 144
Cdd:TIGR00361   1 SQNVSSYRQGTYQFQAVIDTIPKIDGMTDRMSMIVETPDKEKWAAAYRIQSAGEKEQLLYIEPGWSCELTLREPNHALNP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   145 GGFDSQRYAIAQHQPLTGRFLQASVIEPNCSLRAQYLASLQTTLQPYPWNAVILGLGMGERLSVPKEIKNIMRDTGTAHL 224
Cdd:TIGR00361  81 GGFDYQEYLYRQHIHWNGSVTSAQNISEVLSLRAHILSFTNSLLPPDSWTGIVQALTVGERFYVEKEVLTIYQKTGTAHL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   225 MAISGLHIAFAALLAAGLIRSGQIFLPGRWIHWQIPLIGGICCAAFYAWLTGMQPPALRTMVALATWGMLKLSGRQWSGW 304
Cdd:TIGR00361 161 LAISGLHIGLAAGLFYILIRLGQIFLPGRIIHEKAPLLLGLFCAPLYAMLTGAAPPVLRAALALGVYLAGSLVKRRVSSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   305 DVWICCLAAILLMDPVAILSQSLWLSAAAVAALIFWYQWFPCPEWQLPPVLRAVVSLIHLQLGITLLLMPVQIVIFHGIS 384
Cdd:TIGR00361 241 TAICLSYIVLLLFDPYHLLSASFWLSFAAVFSLILWYSIFPQVKTQLGPVLRAVVSLTHLQLGAQLGSLPIQLYHFHGFS 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   385 LTSFIANLLAIPLVTFITVPLILAAMVVH-LSGPLILEQGLWFLADRSLAL-LFWGLKSLPEGWINIAECWQWLSFSPWF 462
Cdd:TIGR00361 321 LISFPANMLAVPFYTFCIVPLILAAVLLLsLSGSFGRLQGSWFDLLISLALrLIWNIADVPEFTIMIAHPWQVLLFLFTV 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   463 LLVVWRLN-AWRTLPAMCVAGGLLMCWPLWQKPRPDE--WQLYMLDVGQGLAMVIARNGKAILYDTGLAWPEGDSGQQLI 539
Cdd:TIGR00361 401 LIILLLLAiEKRSLSQLCVTGGILCCVMFLLFIYPCLssWQVDMLDVGQGLAMFIGANGKGILYDTGEPWREGSLGEKVI 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   540 IPWLHWHNLEPEGVILSHEHLDHRGGLDSILHIWPMLWIRSP----LNWEHHQPCVRGEAWQWQGLRFSAHWPLQGSNDK 615
Cdd:TIGR00361 481 IPFLTAKGIKLEALILSHADQDHIGGAEIILKHHPVKRLVIPkgfvEEGVAIEECKRGDVWQWQGLQFHVLSPEAPDPAS 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   616 GNNHSCVVKVDDGTNSILLTGDIEAPAEQkMLSRYWQQVQATLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWRL 695
Cdd:TIGR00361 561 KNNHSCVLWVDDGGNSWLLTGDLEAEGEQ-EVMRVFPNIKADVLQVGHHGSKTSTSEELIQQVQPKVAIISAGRNNRWHH 639
                         650       660
                  ....*....|....*....|...
gi 90111187   696 PSNKVKHRYQLQGYQWIDTPHQG 718
Cdd:TIGR00361 640 PHQKVLQRLQRHSIRVLRTDQNG 662
ComEC COG2333
DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily ...
499-732 3.26e-77

DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441904 [Multi-domain]  Cd Length: 253  Bit Score: 249.00  E-value: 3.26e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 499 WQLYMLDVGQGLAMVI-ARNGKAILYDTGLAWPeGDSGQQLIIPWLHWHNL-EPEGVILSHEHLDHRGGLDSILHIWPML 576
Cdd:COG2333   1 LRVTFLDVGQGDAILIrTPDGKTILIDTGPRPS-FDAGERVVLPYLRALGIrRLDLLVLTHPDADHIGGLAAVLEAFPVG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 577 WIRSPLNWEH-----------------HQPCVRGEAWQWQGLRFSAHWPLQGS--NDKGNNHSCVVKVDDGTNSILLTGD 637
Cdd:COG2333  80 RVLVSGPPDTsetyerllealkekgipVRPCRAGDTWQLGGVRFEVLWPPEDLleGSDENNNSLVLRLTYGGFSFLLTGD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 638 IEAPAEQKMLSRYwQQVQATLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWRLPSNKVKHRYQLQGYQWIDTPHQ 717
Cdd:COG2333 160 AEAEAEAALLARG-PDLKADVLKVPHHGSKTSSSPAFLEAVRPRVAVISVGRDNRYGHPHPEVLERLRAAGIRVYRTDRD 238
                       250
                ....*....|....*
gi 90111187 718 GQTTVNFSAQGWRIS 732
Cdd:COG2333 239 GAITVTSDGDGLRVE 253
ComA-like_MBL-fold cd07731
Competence protein ComA, ComEC and related proteins; MBL-fold metallo hydrolase domain; This ...
500-664 1.95e-58

Competence protein ComA, ComEC and related proteins; MBL-fold metallo hydrolase domain; This subgroup includes proteins required for natural transformation competence including Neisseria gonorrhoeae ComA, Pseudomonas stutzeri ComA, Bacillus subtilis ComEC (also known as ComE operon protein 3) and Haemophilus influenza ORF2 encoded by the rec-2 gene, as well as Escherichia coli YcaI which does not mediate spontaneous plasmid transformation on nutrient-containing agar plates. It also includes the phosphorylcholine esterase (Pce) domain of choline-binding protein e from streptococcus pneumonia. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.


Pssm-ID: 293817 [Multi-domain]  Cd Length: 179  Bit Score: 196.20  E-value: 1.95e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 500 QLYMLDVGQGLAMVIARNGKAILYDTGLAWPEGdsGQQLIIPWLHWHNLEPEGVILSHEHLDHRGGLDSILHIWPMLWIR 579
Cdd:cd07731   1 RVHFLDVGQGDAILIQTPGKTILIDTGPRDSFG--EDVVVPYLKARGIKKLDYLILTHPDADHIGGLDAVLKNFPVKEVY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 580 SPLNWE-----------------HHQPCVRGEAWQWQGLRFSAHWPLQGSNDKGNNHSCVVKVDDGTNSILLTGDIEAPA 642
Cdd:cd07731  79 MPGVTHttktyedlldaikekgiPVTPCKAGDRWQLGGVSFEVLSPPKDDYDDLNNNSCVLRLTYGGTSFLLTGDAEKEA 158
                       170       180
                ....*....|....*....|..
gi 90111187 643 EQKMLSRYwQQVQATLLQVPHH 664
Cdd:cd07731 159 EEELLASG-PDLLADVLKVGHH 179
Competence pfam03772
Competence protein; Members of this family are integral membrane proteins with 6 predicted ...
203-491 2.03e-47

Competence protein; Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.


Pssm-ID: 461044 [Multi-domain]  Cd Length: 269  Bit Score: 169.32  E-value: 2.03e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   203 GERLSVPKEIKNIMRDTGTAHLMAISGLHIAfaallaaglIRSGQIFLPGRWIHW----QIPLIGGICCAAFYAWLTGMQ 278
Cdd:pfam03772   4 GDRSGLSEELWEAFRKTGLAHLLAISGLHVG---------LVAGLVLFLLRRLLRgpprKLAALLALLFLLLYAILAGFS 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   279 PPALRTMVALATWGMLKLSGRQWSGWDVWICCLAAILLMDPVAILSQSLWLSAAAVAALIFWYQWFPCPEWQLPPVLRAV 358
Cdd:pfam03772  75 PSVLRALIMALLVLLALLLGRRASPLDALALAALLLLLIDPLALLSVGFQLSFLAVAGILLLAPPLQKRLKRLPARILLL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   359 VSLIhlQLGITLLLMPVQIVIFHGISLTSFIANLLAIPLVTFITVPLILAAMVvhLSGPLILEQGLWFLADRSLALLFWG 438
Cdd:pfam03772 155 IALV--SLAAQLATLPLLLYHFGQFSLVGILANLLAVPLVSLLVLPLALLALL--LLLFPPLAALLLWLAGWLLELLLWL 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 90111187   439 LkslpegwiniaecwQWLSFSPWFLLVVWRLNAWRTLPAMCVAGGLLMCWPLW 491
Cdd:pfam03772 231 L--------------EWLASLPGAQLPVGRPPLWLLLLYYLLLLLLLLLLLRR 269
Lactamase_B smart00849
Metallo-beta-lactamase superfamily; Apart from the beta-lactamases a number of other proteins ...
511-657 8.57e-10

Metallo-beta-lactamase superfamily; Apart from the beta-lactamases a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.


Pssm-ID: 214854 [Multi-domain]  Cd Length: 177  Bit Score: 58.72  E-value: 8.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    511 AMVIARNGKAILYDTGLAWPEGdsgqqlIIPWLHWHNLEP-EGVILSHEHLDHRGGLDSILHIWP---------MLWIRS 580
Cdd:smart00849   2 SYLVRDDGGAILIDTGPGEAED------LLAELKKLGPKKiDAIILTHGHPDHIGGLPELLEAPGapvyapegtAELLKD 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    581 PL-----------NWEHHQPCVRGEAWQWQGLRFSA-----HWPlqgsndkgnnHSCVVKVDDGtnSILLTGDIEAPAEQ 644
Cdd:smart00849  76 LLallgelgaeaePAPPDRTLKDGDELDLGGGELEVihtpgHTP----------GSIVLYLPEG--KILFTGDLLFAGGD 143
                          170
                   ....*....|...
gi 90111187    645 KMLSRYWQQVQAT 657
Cdd:smart00849 144 GRTLVDGGDAAAS 156
 
Name Accession Description Interval E-value
PRK11539 PRK11539
ComEC family competence protein; Provisional
1-753 0e+00

ComEC family competence protein; Provisional


Pssm-ID: 236924 [Multi-domain]  Cd Length: 755  Bit Score: 1231.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    1 MKITTVGVCIISGIFPLLILPQLPGTLTLAFLTLFACVLAFIPVKTVRYIALTLLFFVWGILSAKQILWAGETLTGATQD 80
Cdd:PRK11539   1 MSITTVAVAIICGILPLLILPQLPGTWILAFLLLLACLLAFIPVKYCRYIALTLLFFLWGILAAKQILWQGETLTQATQD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   81 AIVEITATDGMTTHYGQ----ITHLQGRRIFPASGLVMYGEYLPQAVCAGQQWSMKLKVRAVHGQLNDGGFDSQRYAIAQ 156
Cdd:PRK11539  81 AIVEITATDGMTTHYGQvvirITHLNGKRIFPALGVVLYGEYLPQAVCAGQRWAMKLKVRAVHGQLNEGGFDSQRYAIAQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  157 HQPLTGRFLQASVIEPNCSLRAQYLASLQTTLQPYPWNAVILGLGMGERLSVPKEIKNIMRDTGTAHLMAISGLHIAFAA 236
Cdd:PRK11539 161 RQPLTGRFLQAKVIDPNCSLRQQYLASLEQTLQPYPWRAIILALAFGERLSVPKEIKNLLRDTGTAHLMAISGLHIAFAA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  237 LLAAGLIRSGQIFLPGRWIHWQIPLIGGICCAAFYAWLTGMQPPALRTMVALATWGMLKLSGRQWSGWDVWICCLAAILL 316
Cdd:PRK11539 241 LLGWGLARGGQFFLPVRWIGWQFPLLGGWLCAAFYAWLAGMQPPALRTVLALTLWGLLRLSGRQCSGWQVWLWCLALILL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  317 MDPVAILSQSLWLSAAAVAALIFWYQWFPCPEWQLPPVLRAVVSLIHLQLGITLLLMPVQIVIFHGISLTSFIANLLAIP 396
Cdd:PRK11539 321 SDPLAVLSDSFWLSALAVAALIFWYQWFPLPEWFLPGWLRAVLRLLHLQLGITLLLMPLQILLFHGISLTSLPANLWAVP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  397 LVTFITVPLILAAMVVHLSGPLilEQGLWFLADRSLALLFWGLKSLPEGWINIAECWQWLSFSPWFLLVVWRLNAWRTLP 476
Cdd:PRK11539 401 LVSFITVPLILLALVLHLLPPL--EQGLWFLADRSLALVFWPLKSLPEGWINIGERWQWLSFSGWLALIIWRFNWWRSYP 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  477 AMCVAGGLLMCWPLWQKPRPDEWQLYMLDVGQGLAMVIARNGKAILYDTGLAWPEGDSGQQLIIPWLHWHNLEPEGVILS 556
Cdd:PRK11539 479 AMCVAVLLLMCWPLWQRPREYEWRVDMLDVGHGLAVVIERNGKAILYDTGNAWPTGDSAQQVIIPWLRWHGLTPEGIILS 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  557 HEHLDHRGGLDSILHIWPMLWIRSPLNWEHHQPCVRGEAWQWQGLRFSAHWPLQGSNDKGNNHSCVVKVDDGTNSILLTG 636
Cdd:PRK11539 559 HEHLDHRGGLASLLHAWPMAWIRSPLNWANHLPCVRGEQWQWQGLTFSVHWPLEQSNDAGNNDSCVIRVDDGKHSILLTG 638
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187  637 DIEAPAEQKMLSRYWQQVQATLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWRLPSNKVKHRYQLQGYQWIDTPH 716
Cdd:PRK11539 639 DLEAQAEQKLLSRYWQQLAATLLQVPHHGSNTSSSLPFIRAVNGKVALASASRYNAWRLPSVKVKQRYQQQGYQWRDTPH 718
                        730       740       750
                 ....*....|....*....|....*....|....*..
gi 90111187  717 QGQTTVNFSAQGWRISSLREQILPRWYHQWFGVPVDN 753
Cdd:PRK11539 719 SGQLSVYFSADGWRISGYREQILPRWYHQWFGVPVDN 755
ComEC_Rec2 TIGR00361
DNA internalization-related competence protein ComEC/Rec2; Apparant orthologs are found in 5 ...
65-718 0e+00

DNA internalization-related competence protein ComEC/Rec2; Apparant orthologs are found in 5 species so far (Haemophilus influenzae, Escherichia coli, Bacillus subtilis, Neisseria gonorrhoeae, Streptococcus pneumoniae), of which all but E. coli are model systems for the study of competence for natural transformation. This protein is a predicted multiple membrane-spanning protein likely to be involved in DNA internalization. In a large number of bacterial species not known to exhibit competence, this protein is replaced by a half-length N-terminal homolog of unknown function, modelled by the related model ComEC_N-term. The role for this protein in species that are not naturally transformable is unknown. [Cellular processes, DNA transformation]


Pssm-ID: 273036 [Multi-domain]  Cd Length: 662  Bit Score: 1006.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    65 KQILWAGETLTGATQDAIVEITATDGMTTHYGQITHLQGRRIFPASGLVMYGEYLPQAVCAGQQWSMKLKVRAVHGQLND 144
Cdd:TIGR00361   1 SQNVSSYRQGTYQFQAVIDTIPKIDGMTDRMSMIVETPDKEKWAAAYRIQSAGEKEQLLYIEPGWSCELTLREPNHALNP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   145 GGFDSQRYAIAQHQPLTGRFLQASVIEPNCSLRAQYLASLQTTLQPYPWNAVILGLGMGERLSVPKEIKNIMRDTGTAHL 224
Cdd:TIGR00361  81 GGFDYQEYLYRQHIHWNGSVTSAQNISEVLSLRAHILSFTNSLLPPDSWTGIVQALTVGERFYVEKEVLTIYQKTGTAHL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   225 MAISGLHIAFAALLAAGLIRSGQIFLPGRWIHWQIPLIGGICCAAFYAWLTGMQPPALRTMVALATWGMLKLSGRQWSGW 304
Cdd:TIGR00361 161 LAISGLHIGLAAGLFYILIRLGQIFLPGRIIHEKAPLLLGLFCAPLYAMLTGAAPPVLRAALALGVYLAGSLVKRRVSSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   305 DVWICCLAAILLMDPVAILSQSLWLSAAAVAALIFWYQWFPCPEWQLPPVLRAVVSLIHLQLGITLLLMPVQIVIFHGIS 384
Cdd:TIGR00361 241 TAICLSYIVLLLFDPYHLLSASFWLSFAAVFSLILWYSIFPQVKTQLGPVLRAVVSLTHLQLGAQLGSLPIQLYHFHGFS 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   385 LTSFIANLLAIPLVTFITVPLILAAMVVH-LSGPLILEQGLWFLADRSLAL-LFWGLKSLPEGWINIAECWQWLSFSPWF 462
Cdd:TIGR00361 321 LISFPANMLAVPFYTFCIVPLILAAVLLLsLSGSFGRLQGSWFDLLISLALrLIWNIADVPEFTIMIAHPWQVLLFLFTV 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   463 LLVVWRLN-AWRTLPAMCVAGGLLMCWPLWQKPRPDE--WQLYMLDVGQGLAMVIARNGKAILYDTGLAWPEGDSGQQLI 539
Cdd:TIGR00361 401 LIILLLLAiEKRSLSQLCVTGGILCCVMFLLFIYPCLssWQVDMLDVGQGLAMFIGANGKGILYDTGEPWREGSLGEKVI 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   540 IPWLHWHNLEPEGVILSHEHLDHRGGLDSILHIWPMLWIRSP----LNWEHHQPCVRGEAWQWQGLRFSAHWPLQGSNDK 615
Cdd:TIGR00361 481 IPFLTAKGIKLEALILSHADQDHIGGAEIILKHHPVKRLVIPkgfvEEGVAIEECKRGDVWQWQGLQFHVLSPEAPDPAS 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   616 GNNHSCVVKVDDGTNSILLTGDIEAPAEQkMLSRYWQQVQATLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWRL 695
Cdd:TIGR00361 561 KNNHSCVLWVDDGGNSWLLTGDLEAEGEQ-EVMRVFPNIKADVLQVGHHGSKTSTSEELIQQVQPKVAIISAGRNNRWHH 639
                         650       660
                  ....*....|....*....|...
gi 90111187   696 PSNKVKHRYQLQGYQWIDTPHQG 718
Cdd:TIGR00361 640 PHQKVLQRLQRHSIRVLRTDQNG 662
ComEC COG2333
DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily ...
499-732 3.26e-77

DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441904 [Multi-domain]  Cd Length: 253  Bit Score: 249.00  E-value: 3.26e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 499 WQLYMLDVGQGLAMVI-ARNGKAILYDTGLAWPeGDSGQQLIIPWLHWHNL-EPEGVILSHEHLDHRGGLDSILHIWPML 576
Cdd:COG2333   1 LRVTFLDVGQGDAILIrTPDGKTILIDTGPRPS-FDAGERVVLPYLRALGIrRLDLLVLTHPDADHIGGLAAVLEAFPVG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 577 WIRSPLNWEH-----------------HQPCVRGEAWQWQGLRFSAHWPLQGS--NDKGNNHSCVVKVDDGTNSILLTGD 637
Cdd:COG2333  80 RVLVSGPPDTsetyerllealkekgipVRPCRAGDTWQLGGVRFEVLWPPEDLleGSDENNNSLVLRLTYGGFSFLLTGD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 638 IEAPAEQKMLSRYwQQVQATLLQVPHHGSNTSSSLPLIQRVNGKVALASASRYNAWRLPSNKVKHRYQLQGYQWIDTPHQ 717
Cdd:COG2333 160 AEAEAEAALLARG-PDLKADVLKVPHHGSKTSSSPAFLEAVRPRVAVISVGRDNRYGHPHPEVLERLRAAGIRVYRTDRD 238
                       250
                ....*....|....*
gi 90111187 718 GQTTVNFSAQGWRIS 732
Cdd:COG2333 239 GAITVTSDGDGLRVE 253
ComEC_N-term TIGR00360
ComEC/Rec2-related protein; The related model ComEC_Rec2 (TIGR00361) describes a set of ...
221-405 2.01e-59

ComEC/Rec2-related protein; The related model ComEC_Rec2 (TIGR00361) describes a set of proteins of ~ 700-800 residues, one each from a number of different species, of which most can become competent for natural transformation with exogenous DNA. The best-studied examples are ComEC from Bacillus subtilis and Rec-2 from Haemophilus influenzae, where the protein appears to form part of the DNA import structure. This model represents a region found in full-length ComEC/Rec2 and shorter homologs of unknown function from large number of additional bacterial species, most of which are not known to become competent for transformation (an exception is Helicobacter pylori). [Unknown function, General]


Pssm-ID: 273035 [Multi-domain]  Cd Length: 171  Bit Score: 198.37  E-value: 2.01e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   221 TAHLMAISGLHIAFAALLaaglirsGQIFLPGRWIHWQIPLIGGICCAAFYAWLTGMQPPALRTMVALATWGMLKLSGRQ 300
Cdd:TIGR00360   1 IAHLLAISGLHVSLLFGI-------VQYFLPKRGIHWYLALIVGLIFLLFYLFLTGFAPSALRAFLALVLVLAFKLSLRK 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   301 WSGWDVWICCLAAILLMDPVAILSQSLWLSAAAVAALifwYQWFPCPEWQLPPVLravvSLIHLQLGITLLLMPVQIVIF 380
Cdd:TIGR00360  74 LNLIGALLLSAIVILLMNPVALLSFGFQLSFLATFGL---VVMFPNFQQLLRPLS----SLIHVQLILILWSTPILLYLF 146
                         170       180
                  ....*....|....*....|....*
gi 90111187   381 HGISLTSFIANLLAIPLVTFITVPL 405
Cdd:TIGR00360 147 HGLSPISVLANLLAIPLYSFLLLPG 171
ComEC COG0658
DNA uptake channel protein ComEC, N-terminal domain [Intracellular trafficking, secretion, and ...
195-748 9.95e-59

DNA uptake channel protein ComEC, N-terminal domain [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440423 [Multi-domain]  Cd Length: 543  Bit Score: 208.50  E-value: 9.95e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 195 AVILGLGMGERLSVPKEIKNIMRDTGTAHLMAISGLHIAfaallaaglIRSGQIFLPGRWIH--WQIPLIGGICCAAFYA 272
Cdd:COG0658   2 GLLAALLLGDRSGLSPELWEAFRATGLAHLLAISGLHVG---------LVAGLVLLLLRRLGppRRLAALLALLALLLYA 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 273 WLTGMQPPALRTMVALATWGMLKLSGRQWSGWDVWICCLAAILLMDPVAILSQSLWLSAAAVAALIFWYQWFPcpEWQLP 352
Cdd:COG0658  73 LLAGFSPSVLRAALMLALVLLALLLGRRASSLRALALAALLLLLLDPLALLSPGFQLSFLAVAGLILLYPPLR--RRLAR 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 353 PVLRAVVSLIHLQLGITLLLMPVQIVIFHGISLTSFIANLLAIPLVTFITVPLILAAMVVHLSGPLILEQGLWFLADRSL 432
Cdd:COG0658 151 RLPRWLAELLAVSLAAQLATLPLLLYLFGQVSLVSLLANLLAVPLVSLIVVPGLLLALLLLPLLPPLALLLLLLALLLLL 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 433 ALLFWGlksLPEGWINIAECWQWLSFSPWFLLVVWRLNAWRTLPAMCVAGGLLMCWPLWQKPRPDEWQLYMLDVGQGLAM 512
Cdd:COG0658 231 LLLLLL---LALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLGLLGG 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 513 VIARNGKAILYDTGLAWPEGDSGQQLIIPWLHWHNLEPEGVILSHEHLDHRGGLDSILHIWPMLWIRSPLNWEHHQPCVR 592
Cdd:COG0658 308 VGVGGGDGGLLLGGRGLLGVLGGLLLLLLLLLLLLLLLLLGLLLVLLLLLLLALLLGLLLLLLAALLGLAAALLLLLALL 387
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 593 GEAWQWQGLRFSAHWPLQGSNDKGNNHSCVVKVDDGTNSILLTGDIEAPAEQKMLSRYWQQVQATLLQVPHHGSNTSSSL 672
Cdd:COG0658 388 ALLALLALALLLGALVGLLVVLLLALRSLLLGGGLLLLLLLLLLLLALALLLLLLALLSLLLLLLLLLALLLLLLGSLLL 467
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90111187 673 PLIQRVNGKVALASASRYNAWRLPSNKVKHRYQLQGYQWIDTPHQGQTTVNFSAQGWRISSLREQILPRWYHQWFG 748
Cdd:COG0658 468 SLLLLLALASSALASLSSSSSGAAVLAAAGAVALLASGGLAALAPGALGLLGGRGRRGTRRGGRLRRTRLLRRLVR 543
ComA-like_MBL-fold cd07731
Competence protein ComA, ComEC and related proteins; MBL-fold metallo hydrolase domain; This ...
500-664 1.95e-58

Competence protein ComA, ComEC and related proteins; MBL-fold metallo hydrolase domain; This subgroup includes proteins required for natural transformation competence including Neisseria gonorrhoeae ComA, Pseudomonas stutzeri ComA, Bacillus subtilis ComEC (also known as ComE operon protein 3) and Haemophilus influenza ORF2 encoded by the rec-2 gene, as well as Escherichia coli YcaI which does not mediate spontaneous plasmid transformation on nutrient-containing agar plates. It also includes the phosphorylcholine esterase (Pce) domain of choline-binding protein e from streptococcus pneumonia. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.


Pssm-ID: 293817 [Multi-domain]  Cd Length: 179  Bit Score: 196.20  E-value: 1.95e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 500 QLYMLDVGQGLAMVIARNGKAILYDTGLAWPEGdsGQQLIIPWLHWHNLEPEGVILSHEHLDHRGGLDSILHIWPMLWIR 579
Cdd:cd07731   1 RVHFLDVGQGDAILIQTPGKTILIDTGPRDSFG--EDVVVPYLKARGIKKLDYLILTHPDADHIGGLDAVLKNFPVKEVY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187 580 SPLNWE-----------------HHQPCVRGEAWQWQGLRFSAHWPLQGSNDKGNNHSCVVKVDDGTNSILLTGDIEAPA 642
Cdd:cd07731  79 MPGVTHttktyedlldaikekgiPVTPCKAGDRWQLGGVSFEVLSPPKDDYDDLNNNSCVLRLTYGGTSFLLTGDAEKEA 158
                       170       180
                ....*....|....*....|..
gi 90111187 643 EQKMLSRYwQQVQATLLQVPHH 664
Cdd:cd07731 159 EEELLASG-PDLLADVLKVGHH 179
Competence pfam03772
Competence protein; Members of this family are integral membrane proteins with 6 predicted ...
203-491 2.03e-47

Competence protein; Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.


Pssm-ID: 461044 [Multi-domain]  Cd Length: 269  Bit Score: 169.32  E-value: 2.03e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   203 GERLSVPKEIKNIMRDTGTAHLMAISGLHIAfaallaaglIRSGQIFLPGRWIHW----QIPLIGGICCAAFYAWLTGMQ 278
Cdd:pfam03772   4 GDRSGLSEELWEAFRKTGLAHLLAISGLHVG---------LVAGLVLFLLRRLLRgpprKLAALLALLFLLLYAILAGFS 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   279 PPALRTMVALATWGMLKLSGRQWSGWDVWICCLAAILLMDPVAILSQSLWLSAAAVAALIFWYQWFPCPEWQLPPVLRAV 358
Cdd:pfam03772  75 PSVLRALIMALLVLLALLLGRRASPLDALALAALLLLLIDPLALLSVGFQLSFLAVAGILLLAPPLQKRLKRLPARILLL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   359 VSLIhlQLGITLLLMPVQIVIFHGISLTSFIANLLAIPLVTFITVPLILAAMVvhLSGPLILEQGLWFLADRSLALLFWG 438
Cdd:pfam03772 155 IALV--SLAAQLATLPLLLYHFGQFSLVGILANLLAVPLVSLLVLPLALLALL--LLLFPPLAALLLWLAGWLLELLLWL 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 90111187   439 LkslpegwiniaecwQWLSFSPWFLLVVWRLNAWRTLPAMCVAGGLLMCWPLW 491
Cdd:pfam03772 231 L--------------EWLASLPGAQLPVGRPPLWLLLLYYLLLLLLLLLLLRR 269
Lactamase_B pfam00753
Metallo-beta-lactamase superfamily;
504-688 1.34e-19

Metallo-beta-lactamase superfamily;


Pssm-ID: 425851 [Multi-domain]  Cd Length: 196  Bit Score: 87.42  E-value: 1.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   504 LDVGQGLAMVIARNGKAILYDTGLAWPEGDsgqQLIIPWLHWHNLEPEGVILSHEHLDHRGGLDSILHIWPMLWIRSPLN 583
Cdd:pfam00753   1 LGPGQVNSYLIEGGGGAVLIDTGGSAEAAL---LLLLAALGLGPKDIDAVILTHGHFDHIGGLGELAEATDVPVIVVAEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187   584 WEHHQPCVRG------------------EAWQWQGLRFSAHWPLQGSNDKGNNHSCVVKVDDGTNSILLTGDIEAPAEQK 645
Cdd:pfam00753  78 ARELLDEELGlaasrlglpgppvvplppDVVLEEGDGILGGGLGLLVTHGPGHGPGHVVVYYGGGKVLFTGDLLFAGEIG 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 90111187   646 MLSRywqqvQATLLQVPHHGSNTSSSLPLIQRVNGKVALASAS 688
Cdd:pfam00753 158 RLDL-----PLGGLLVLHPSSAESSLESLLKLAKLKAAVIVPG 195
Lactamase_B smart00849
Metallo-beta-lactamase superfamily; Apart from the beta-lactamases a number of other proteins ...
511-657 8.57e-10

Metallo-beta-lactamase superfamily; Apart from the beta-lactamases a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.


Pssm-ID: 214854 [Multi-domain]  Cd Length: 177  Bit Score: 58.72  E-value: 8.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    511 AMVIARNGKAILYDTGLAWPEGdsgqqlIIPWLHWHNLEP-EGVILSHEHLDHRGGLDSILHIWP---------MLWIRS 580
Cdd:smart00849   2 SYLVRDDGGAILIDTGPGEAED------LLAELKKLGPKKiDAIILTHGHPDHIGGLPELLEAPGapvyapegtAELLKD 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    581 PL-----------NWEHHQPCVRGEAWQWQGLRFSA-----HWPlqgsndkgnnHSCVVKVDDGtnSILLTGDIEAPAEQ 644
Cdd:smart00849  76 LLallgelgaeaePAPPDRTLKDGDELDLGGGELEVihtpgHTP----------GSIVLYLPEG--KILFTGDLLFAGGD 143
                          170
                   ....*....|...
gi 90111187    645 KMLSRYWQQVQAT 657
Cdd:smart00849 144 GRTLVDGGDAAAS 156
COG1237 COG1237
Metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only];
509-572 7.70e-06

Metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only];


Pssm-ID: 440850  Cd Length: 273  Bit Score: 48.34  E-value: 7.70e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 90111187 509 GLAMVIARNGKAILYDTGlawpegdSGQQLIipwlhwHNLE--------PEGVILSHEHLDHRGGLDSILHI 572
Cdd:COG1237  22 GLSALIETEGKRILFDTG-------QSDVLL------KNAEklgidlsdIDAVVLSHGHYDHTGGLPALLEL 80
DHPS-like_MBL-fold cd07713
Methanocaldococcus jannaschii dihydropteroate synthase, Thermoanaerobacter tengcongensis Tflp, ...
509-574 1.10e-04

Methanocaldococcus jannaschii dihydropteroate synthase, Thermoanaerobacter tengcongensis Tflp, and related proteins; MBL-fold metallo hydrolase domain; This subgroup includes Methanocaldococcus jannaschii 7,8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate synthase (EC 2.5.1.15), a folate biosynthetic enzyme also known as dihydropteroate synthase and 7,8 dihydropteroate synthase. Thermoanaerobacter tengcongensis Tflp is a ferredoxin-like member. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.


Pssm-ID: 293799  Cd Length: 269  Bit Score: 44.54  E-value: 1.10e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111187 509 GLAMVIARNGKAILYDTGLawpegdSGqqLIIpwlhwHNLE--------PEGVILSHEHLDHRGGLDSILHIWP 574
Cdd:cd07713  20 GLSLLIETEGKKILFDTGQ------SG--VLL-----HNAKklgidlsdIDAVVLSHGHYDHTGGLKALLELNP 80
metallo-hydrolase-like_MBL-fold cd06262
mainly hydrolytic enzymes and related proteins which carry out various biological functions; ...
513-570 2.97e-04

mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain; Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.


Pssm-ID: 293792 [Multi-domain]  Cd Length: 188  Bit Score: 42.66  E-value: 2.97e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 90111187 513 VIARNGKAILYDTGlawpegDSGQQLIIPWLHWHNLEPEGVILSHEHLDHRGGLDSIL 570
Cdd:cd06262  15 VSDEEGEAILIDPG------AGALEKILEAIEELGLKIKAILLTHGHFDHIGGLAELK 66
GloB COG0491
Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General ...
501-567 5.90e-04

Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only];


Pssm-ID: 440257 [Multi-domain]  Cd Length: 215  Bit Score: 41.98  E-value: 5.90e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111187 501 LYMLDVGQGL------AMVIARNGKAILYDTGLAWPEGDSgqqlIIPWLHWHNLEPEGVILSHEHLDHRGGLD 567
Cdd:COG0491   1 VYVLPGGTPGaglgvnSYLIVGGDGAVLIDTGLGPADAEA----LLAALAALGLDIKAVLLTHLHPDHVGGLA 69
yflN-like_MBL-fold cd07721
uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase ...
500-573 3.58e-03

uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain; This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.


Pssm-ID: 293807 [Multi-domain]  Cd Length: 202  Bit Score: 39.51  E-value: 3.58e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 90111187 500 QLYMLDVGQGL-AMVIARNGKAILYDTGLAWPEGdsgqqLIIPWLHWHNLEPE---GVILSHEHLDHRGGLDSILHIW 573
Cdd:cd07721   1 GVYQLPLLPPVnAYLIEDDDGLTLIDTGLPGSAK-----RILKALRELGLSPKdirRILLTHGHIDHIGSLAALKEAP 73
RNaseJ_MBL-fold cd07714
RNAaseJ, MBL-fold metallo-hydrolase domain; RNase J, also called Ribonuclease J, is a ...
512-578 4.17e-03

RNAaseJ, MBL-fold metallo-hydrolase domain; RNase J, also called Ribonuclease J, is a prokaryotic ribonuclease which plays a key part in RNA processing and in RNA degradation. It can act as an endonuclease which is specific for single-stranded regions of RNA irrespective of their sequence or location, and as a processive 5' exonuclease which only acts on substrates having a single phosphate or a hydroxyl at the 5' end. Many bacterial species have only one RNase J, but some, such as Bacillus subtilis, have two. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.


Pssm-ID: 293800 [Multi-domain]  Cd Length: 248  Bit Score: 39.70  E-value: 4.17e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90111187 512 MVIARNGKAILYDTGLAWPEGDS-GQQLIIP---WLHWHNLEPEGVILSHEHLDHRGGLDsilHIWPMLWI 578
Cdd:cd07714  14 YVVEYDDDIIIIDCGLKFPDEDMpGVDYIIPdfsYLEENKDKIKGIFITHGHEDHIGALP---YLLPELNV 81
DUF4131 pfam13567
Domain of unknown function (DUF4131); This domain is frequently found to the N-terminus of the ...
27-157 6.68e-03

Domain of unknown function (DUF4131); This domain is frequently found to the N-terminus of the Competence domain, pfam03772.


Pssm-ID: 379269  Cd Length: 165  Bit Score: 38.14  E-value: 6.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111187    27 LTLAFLTLFACVLAFIPVKTVRYIALTLLFFVWGILSAKQILWAGETLTGATQDAIVEITA--------TDGMTTHYGQI 98
Cdd:pfam13567  11 AALLLLLLLLLFLLRRKRRRTLLLLLLLLLLAGLGAALRAPRPNSNDLSHFLDGKEVVVEGvvaslpevTGDGVRFVLEV 90
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 90111187    99 THL-QGRRIFPASGLVM--YGEYLPQAVCAGQQWSMKLKVRAVHGQLNDGGFDSQRYAIAQH 157
Cdd:pfam13567  91 ERVlLGGETKPVSGRVLvtVRKDPAEALQPGDRLRLTGKLKRPRGPGNPGGFDYRRYLARQG 152
RnjA COG0595
mRNA degradation ribonuclease J1/J2 [Translation, ribosomal structure and biogenesis];
512-576 7.06e-03

mRNA degradation ribonuclease J1/J2 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440360 [Multi-domain]  Cd Length: 553  Bit Score: 39.66  E-value: 7.06e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90111187 512 MVIARNGKAILYDTGLAWPEGDS-GQQLIIP---WL--HWHNLEpeGVILSHEHLDHRGGldsILHIWPML 576
Cdd:COG0595  22 YVYEYDDDIIIVDCGLKFPEDEMpGVDLVIPdisYLeeNKDKIK--GIVLTHGHEDHIGA---LPYLLKEL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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