tetraacyldisaccharide 4'-kinase transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
tetraacyldisaccharide 4'-kinase; Also called lipid-A 4'-kinase. This essential gene encodes an ...
19-326
7.58e-173
tetraacyldisaccharide 4'-kinase; Also called lipid-A 4'-kinase. This essential gene encodes an enzyme in the pathway of lipid A biosynthesis in Gram-negative organisms. A single copy of this protein is found in Gram-negative bacteria. PSI-BLAST converges on this set of apparent orthologs without identifying any other homologs. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 273216 Cd Length: 311 Bit Score: 481.59 E-value: 7.58e-173
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope ...
1-327
1.70e-163
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope biogenesis]; Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 441269 Cd Length: 349 Bit Score: 459.26 E-value: 1.70e-163
Tetraacyldisaccharide-1-P 4'-kinase; This family consists of tetraacyldisaccharide-1-P 4 ...
12-321
1.14e-152
Tetraacyldisaccharide-1-P 4'-kinase; This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130. This enzyme catalyzes the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glu cosam inyl beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. This enzyme is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharide layer (LPS). The family contains a P-loop motif at the N terminus.
Pssm-ID: 460616 Cd Length: 319 Bit Score: 430.84 E-value: 1.14e-152
tetraacyldisaccharide 4'-kinase; Also called lipid-A 4'-kinase. This essential gene encodes an ...
19-326
7.58e-173
tetraacyldisaccharide 4'-kinase; Also called lipid-A 4'-kinase. This essential gene encodes an enzyme in the pathway of lipid A biosynthesis in Gram-negative organisms. A single copy of this protein is found in Gram-negative bacteria. PSI-BLAST converges on this set of apparent orthologs without identifying any other homologs. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 273216 Cd Length: 311 Bit Score: 481.59 E-value: 7.58e-173
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope ...
1-327
1.70e-163
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope biogenesis]; Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 441269 Cd Length: 349 Bit Score: 459.26 E-value: 1.70e-163
Tetraacyldisaccharide-1-P 4'-kinase; This family consists of tetraacyldisaccharide-1-P 4 ...
12-321
1.14e-152
Tetraacyldisaccharide-1-P 4'-kinase; This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130. This enzyme catalyzes the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glu cosam inyl beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. This enzyme is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharide layer (LPS). The family contains a P-loop motif at the N terminus.
Pssm-ID: 460616 Cd Length: 319 Bit Score: 430.84 E-value: 1.14e-152
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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