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Conserved domains on  [gi|16128961|ref|NP_415515|]
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DNA-binding transcriptional dual regulator TorR [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

two-component system response regulator TorR( domain architecture ID 11484930)

two-component system response regulator TorR is a member of the two-component regulatory system TorS/TorR that is involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO); consists of a receiver domain and a helix-turn-helix DNA-binding domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10766 PRK10766
two-component system response regulator TorR;
1-220 4.17e-138

two-component system response regulator TorR;


:

Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 385.93  E-value: 4.17e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    1 MPHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVT 80
Cdd:PRK10766   1 MSYHILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   81 GRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHT--QDNCYRFAGYCLNVSRHTLERDGEPIKL 158
Cdd:PRK10766  81 GRTDSIDRIVGLEMGADDYVTKPLELRELLVRVKNLLWRISLARQAQPHAqeEDNCYRFAGYCLNVSRRTLERNGEPIKL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128961  159 TRAEYEMLVAFVTNPGEILSRERLLRMLSaRRVENPDLRTVDVLIRRLRHKLSADLLVTQHG 220
Cdd:PRK10766 161 TKAEYELLVAFVTNPGQVLSRERLLRMLS-HRVENPNDRTIDVLIRRLRHKLNPDLFVTQHG 221
 
Name Accession Description Interval E-value
PRK10766 PRK10766
two-component system response regulator TorR;
1-220 4.17e-138

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 385.93  E-value: 4.17e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    1 MPHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVT 80
Cdd:PRK10766   1 MSYHILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   81 GRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHT--QDNCYRFAGYCLNVSRHTLERDGEPIKL 158
Cdd:PRK10766  81 GRTDSIDRIVGLEMGADDYVTKPLELRELLVRVKNLLWRISLARQAQPHAqeEDNCYRFAGYCLNVSRRTLERNGEPIKL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128961  159 TRAEYEMLVAFVTNPGEILSRERLLRMLSaRRVENPDLRTVDVLIRRLRHKLSADLLVTQHG 220
Cdd:PRK10766 161 TKAEYELLVAFVTNPGQVLSRERLLRMLS-HRVENPNDRTIDVLIRRLRHKLNPDLFVTQHG 221
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 2-217 3.55e-62

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 192.86  E-value: 3.55e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   2 PHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVT 80
Cdd:COG0745   1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARpSDIPIIMLT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAqphtqdncyrfAGYCLNVSRHTLERDGEPIKLTR 160
Cdd:COG0745  81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVLR-----------VGDLLDLAAREVTRDGEPVELTP 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 16128961 161 AEYEMLVAFVTNPGEILSRERLLRMLSARrvENPDLRTVDVLIRRLRHKLSADLLVT 217
Cdd:COG0745 150 KEFRLLELLMRNPGRVVSREQLLEEVWGY--DYGDDRTVDVHISRLRKKLEDDLIET 204
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 3-115 6.08e-62

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 189.14  E-value: 6.08e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:cd17619   1 PHILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVGIILVTGR 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 16128961  83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKN 115
Cdd:cd17619  81 DDEVDRIVGLEIGADDYVTKPFNPRELLVRAKN 113
resp_reg_YycF NF040534
response regulator YycF;
5-228 1.01e-41

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 141.40  E-value: 1.01e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRSD 84
Cdd:NF040534   3 ILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKKYDMPIIMLTAKDS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   85 RIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHTQDNCYRFAGYCLNVSRHTLERDGEPIKLTRAEYE 164
Cdd:NF040534  83 EIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEEEEEENNEIVIGSLTIHPDAYTVKKRGETIELTHREFE 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128961  165 MLVAFVTNPGEILSRERLLRMLSARRVENpDLRTVDVLIRRLRHKLSAD-----LLVTQHGEGYFLAAD 228
Cdd:NF040534 163 LLHYLAKHIGQVMTREHLLQTVWGYDYFG-DVRTVDVTVRRLREKIEDNpshpeWIVTRRGVGYYLRNP 230
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 5-114 9.16e-32

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 112.24  E-value: 9.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961     5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTGRS 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDpTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 16128961    84 DRIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 153-225 2.70e-17

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 73.36  E-value: 2.70e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128961    153 GEPIKLTRAEYEMLVAFVTNPGEILSRERLLRMLSARRVEnPDLRTVDVLIRRLRHKLSAD----LLVTQHGEGYFL 225
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDED-VDDNTLDVHISRLRKKLEDDgdprLIETVRGVGYRL 76
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 5-114 1.92e-05

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 44.74  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961     5 IVIVEDEPVTQARLQSYFtqEGYTVSVTASGAGLREIMQNQSVDLILLDINLP-DENG-----LMLTRALRERSTVGIIL 78
Cdd:TIGR02915   1 LLIVEDDLGLQKQLKWSF--ADYELAVAADRESAIALVRRHEPAVVTLDLGLPpDADGaseglAALQQILAIAPDTKVIV 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 16128961    79 VTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:TIGR02915  79 ITGNDDRENAVKAIGLGAYDFYQKPIDPDVLKLIVD 114
 
Name Accession Description Interval E-value
PRK10766 PRK10766
two-component system response regulator TorR;
1-220 4.17e-138

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 385.93  E-value: 4.17e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    1 MPHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVT 80
Cdd:PRK10766   1 MSYHILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   81 GRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHT--QDNCYRFAGYCLNVSRHTLERDGEPIKL 158
Cdd:PRK10766  81 GRTDSIDRIVGLEMGADDYVTKPLELRELLVRVKNLLWRISLARQAQPHAqeEDNCYRFAGYCLNVSRRTLERNGEPIKL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128961  159 TRAEYEMLVAFVTNPGEILSRERLLRMLSaRRVENPDLRTVDVLIRRLRHKLSADLLVTQHG 220
Cdd:PRK10766 161 TKAEYELLVAFVTNPGQVLSRERLLRMLS-HRVENPNDRTIDVLIRRLRHKLNPDLFVTQHG 221
PRK11173 PRK11173
two-component response regulator; Provisional
 4-229 2.08e-71

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 217.58  E-value: 2.08e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRS 83
Cdd:PRK11173   5 HILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQANVALMFLTGRD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRI-DLARQAQPHTQDNCYRFAGYCLNV-SRHTLERDGEPIKLTRA 161
Cdd:PRK11173  85 NEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTmNLGTVSEERRSVESYKFNGWELDInSRSLISPDGEQYKLPRS 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128961  162 EYEMLVAFVTNPGEILSRERLLRMLSARRVENPDlRTVDVLIRRLR-----HKLSADLLVTQHGEGYFLAADV 229
Cdd:PRK11173 165 EFRAMLHFCENPGKIQSRAELLKKMTGRELKPHD-RTVDVTIRRIRkhfesTPDTPEIIATIHGEGYRFCGDL 236
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 2-217 3.55e-62

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 192.86  E-value: 3.55e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   2 PHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVT 80
Cdd:COG0745   1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARpSDIPIIMLT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAqphtqdncyrfAGYCLNVSRHTLERDGEPIKLTR 160
Cdd:COG0745  81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVLR-----------VGDLLDLAAREVTRDGEPVELTP 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 16128961 161 AEYEMLVAFVTNPGEILSRERLLRMLSARrvENPDLRTVDVLIRRLRHKLSADLLVT 217
Cdd:COG0745 150 KEFRLLELLMRNPGRVVSREQLLEEVWGY--DYGDDRTVDVHISRLRKKLEDDLIET 204
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 3-115 6.08e-62

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 189.14  E-value: 6.08e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:cd17619   1 PHILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVGIILVTGR 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 16128961  83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKN 115
Cdd:cd17619  81 DDEVDRIVGLEIGADDYVTKPFNPRELLVRAKN 113
ompR PRK09468
osmolarity response regulator; Provisional
 3-213 8.23e-50

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 162.45  E-value: 8.23e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTG 81
Cdd:PRK09468   6 YKILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNnPTPIIMLTA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   82 RSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHTQDNCYRFAGYCLNVSRHTLERDGEPIKLTRA 161
Cdd:PRK09468  86 KGEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRQAPELPGAPSQEEEVIAFGKFKLNLGTRELFRGDEPMPLTTG 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 16128961  162 EYEMLVAFVTNPGEILSRERLLRMLSARRVENPDlRTVDVLIRRLRHKLSAD 213
Cdd:PRK09468 166 EFAVLKALVSHPREPLSRDKLMNLARGREYSAME-RSIDVQISRLRRLIEED 216
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-226 9.14e-46

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 152.04  E-value: 9.14e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    1 MPHhIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILV 79
Cdd:PRK11083   3 QPT-ILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFhPALPVIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   80 TGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRidLARQAQPHTQDNCYRFAgycLNVSRHTLERDGEPIKLT 159
Cdd:PRK11083  82 TARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRR--VKKFAAPSPVIRIGHFE---LDEPAARISYFGTPLTLT 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128961  160 RAEYEMLVAFVTNPGEILSRERLLRMLSARRVENPDlRTVDVLIRRLRHKL-----SADLLVTQHGEGYFLA 226
Cdd:PRK11083 157 RYEFLLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYD-RTVDTHIKTLRAKLrainpDLSPINTHRGMGYSLR 227
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 4-229 1.83e-45

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 151.50  E-value: 1.83e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTG-R 82
Cdd:PRK13856   3 HVLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQFNRVLASETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISGdR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLwRIdlaRQAQPHTQD-NCYRFAGYCLNVSRHTL-ERDGEPIKLTR 160
Cdd:PRK13856  83 LEEADKVVALELGATDFIAKPFGTREFLARIRVAL-RV---RPNVVRTKDrRSFCFADWTLNLRQRRLiSEAGGEVKLTA 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16128961  161 AEYEMLVAFVTNPGEILSRERLlrmLSARRVENPDL--RTVDVLIRRLRHKLSAD-----LLVTQHGEGYFLAADV 229
Cdd:PRK13856 159 GEFNLLVAFLEKPRDVLSREQL---LIASRVREEEVydRSIDVLILRLRRKLEQDpanpqLIKTARGAGYFFDADV 231
resp_reg_YycF NF040534
response regulator YycF;
5-228 1.01e-41

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 141.40  E-value: 1.01e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRSD 84
Cdd:NF040534   3 ILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKKYDMPIIMLTAKDS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   85 RIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHTQDNCYRFAGYCLNVSRHTLERDGEPIKLTRAEYE 164
Cdd:NF040534  83 EIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEEEEEENNEIVIGSLTIHPDAYTVKKRGETIELTHREFE 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128961  165 MLVAFVTNPGEILSRERLLRMLSARRVENpDLRTVDVLIRRLRHKLSAD-----LLVTQHGEGYFLAAD 228
Cdd:NF040534 163 LLHYLAKHIGQVMTREHLLQTVWGYDYFG-DVRTVDVTVRRLREKIEDNpshpeWIVTRRGVGYYLRNP 230
orf27 CHL00148
Ycf27; Reviewed
 3-223 1.83e-41

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 141.01  E-value: 1.83e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:CHL00148   7 EKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVPIIMLTAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHTQDNCYRFAGYCLNVSRHTLERDGEPIKLTRAE 162
Cdd:CHL00148  87 GDVSDRITGLELGADDYVVKPFSPKELEARIRSVLRRTNKKSFSSKIPNSSIIRIGFLKIDLNKKQVYKNNERIRLTGME 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128961  163 YEMLVAFVTNPGEILSRERLLRMLSARRVENP-DLRTVDVLIRRLRHKLSAD-----LLVTQHGEGY 223
Cdd:CHL00148 167 FSLLELLISKSGEIFSRATILKEVWGYTPERHiDTRVVDVHISRLRAKLEDDpsnpdLILTARGTGY 233
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 3-230 1.86e-39

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 135.97  E-value: 1.86e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:PRK10710  11 PRILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHTQDncyrfAGYCLNVSRHTLERDGEPIKLTRAE 162
Cdd:PRK10710  91 IEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAE-----SPLIIDESRFQASWRGKMLDLTPAE 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16128961  163 YEMLVAFVTNPGEILSRERLLRML--SARRVENpdlRTVDVLIRRLRHKLSA-----DLLVTQHGEGYFLAADVC 230
Cdd:PRK10710 166 FRLLKTLSHEPGKVFSREQLLNHLydDYRVVTD---RTIDSHIKNLRRKLESldaeqSFIRAVYGVGYRWEADAC 237
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 7-103 1.06e-34

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 119.05  E-value: 1.06e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   7 IVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRE-RSTVGIILVTGRSDR 85
Cdd:cd17574   2 VVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREkGSDIPIIMLTAKDEE 81

                        90
                ....*....|....*...
gi 16128961  86 IDRIVGLEMGADDYVTKP 103
Cdd:cd17574  82 EDKVLGLELGADDYITKP 99
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
3-210 1.85e-33

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 120.29  E-value: 1.85e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMqNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:PRK10955   2 NKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLL-DDSIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHTQDNCYRFA-GYCLNVSRHTLERDGEPIKLTRA 161
Cdd:PRK10955  81 GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEVdALSLNPGRQEASFDGQTLELTGT 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 16128961  162 EYEMLVAFVTNPGEILSRERLLRMLSARRVeNPDLRTVDVLIRRLRHKL 210
Cdd:PRK10955 161 EFTLLYLLAQHLGQVVSREHLSQEVLGKRL-TPFDRAIDMHISNLRRKL 208
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 4-117 5.99e-32

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 112.86  E-value: 5.99e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRS 83
Cdd:cd19938   1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDVPIIMVTARV 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 16128961  84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd19938  81 EEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 5-114 9.16e-32

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 112.24  E-value: 9.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961     5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTGRS 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDpTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 16128961    84 DRIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK10643 PRK10643
two-component system response regulator PmrA;
5-228 1.02e-31

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 115.52  E-value: 1.02e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGL-MLTRALRERSTVGIILVTGRS 83
Cdd:PRK10643   3 ILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLhLLRRWRQKKYTLPVLILTARD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRidlaRQAQphtQDNCYRFAGYCLNVSRHTLERDGEPIKLTRAEY 163
Cdd:PRK10643  83 TLEDRVAGLDVGADDYLVKPFALEELHARIRALIRR----HQGQ---GENELQVGNLTLNLGRQQVWLDGQELILTPKEF 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16128961  164 EMLVAFVTNPGEILSRERLLRMLSARRVEnPDLRTVDVLIRRLRHKLSADLLVTQHGEGYFLAAD 228
Cdd:PRK10643 156 ALLSRLMLKAGSPVHREILYQDIYNWDDE-PSSNTLEVHIHNLRDKVGKDRIRTVRGFGYMLVAN 219
PRK11517 PRK11517
DNA-binding response regulator HprR;
5-228 3.29e-31

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 114.23  E-value: 3.29e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGA-GLREIMQnQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRS 83
Cdd:PRK11517   3 ILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRdGLYLALK-DDYALIILDIMLPGMDGWQILQTLRTAKQTPVICLTARD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLwridlaRQAQPHtqDNCYRFAGYCLNVSRHTLERDGEPIKLTRAEY 163
Cdd:PRK11517  82 SVDDRVRGLDSGANDYLVKPFSFSELLARVRAQL------RQHHAL--NSTLEISGLRMDSVSQSVSRDNISITLTRKEF 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128961  164 EMLVAFVTNPGEILSRERLLRMLSARRVENpDLRTVDVLIRRLRHKLS----ADLLVTQHGEGYFLAAD 228
Cdd:PRK11517 154 QLLWLLASRAGEIIPRTVIASEIWGINFDS-DTNTVDVAIRRLRAKVDdpfpEKLIATIRGMGYSFVAV 221
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 2-113 1.64e-30

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 111.15  E-value: 1.64e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   2 PHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER---STVGIIL 78
Cdd:COG3706   1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADprtADIPIIF 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16128961  79 VTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRV 113
Cdd:COG3706  81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 5-119 9.71e-30

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 107.01  E-value: 9.71e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRSD 84
Cdd:cd17623   1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLMLTARGD 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16128961  85 RIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWR 119
Cdd:cd17623  81 DIDRILGLELGADDYLPKPFNPRELVARIRAILRR 115
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 5-227 1.13e-29

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 110.40  E-value: 1.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERST-VGIILVTGRS 83
Cdd:PRK09836   3 LLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKgMPILLLTALG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLwridlaRQAQPHTQDNCYRFAGYCLNVSRHTLERDGEPIKLTRAEY 163
Cdd:PRK09836  83 TIEHRVKGLELGADDYLVKPFAFAELLARVRTLL------RRGAAVIIESQFQVADLMVDLVSRKVTRSGTRITLTSKEF 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128961  164 EMLVAFVTNPGEILSRERLLRMLSARRVENpDLRTVDVLIRRLRHKLSAD----LLVTQHGEGYFLAA 227
Cdd:PRK09836 157 TLLEFFLRHQGEVLPRSLIASQVWDMNFDS-DTNAIDVAVKRLRGKIDNDfepkLIQTVRGVGYMLEV 223
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 7-117 1.44e-29

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 106.59  E-value: 1.44e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   7 IVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALR---ERSTVGIILVTGRS 83
Cdd:cd19937   2 VVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRsdpKTSSIPIIMLTAKG 81

                        90       100       110
                ....*....|....*....|....*....|....
gi 16128961  84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd19937  82 EEFDKVLGLELGADDYITKPFSPRELLARVKAVL 115
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-117 1.31e-28

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 104.55  E-value: 1.31e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   1 MPHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER---STVGII 77
Cdd:COG0784   4 GGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALprlPDIPII 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 16128961  78 LVTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:COG0784  84 ALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLL 123
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 5-223 2.66e-28

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 106.81  E-value: 2.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTAS-GAGLREIMQNQSvDLILLDINLPDENGLMLTRALRERSTVGIILVTGRS 83
Cdd:PRK10529   4 VLIVEDEQAIRRFLRTALEGDGMRVFEAETlQRGLLEAATRKP-DLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLSARS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELVVRVknllwRIDLARQAQPHTQDNCYRFAGYCLNVSRHTLERDGEPIKLTRAEY 163
Cdd:PRK10529  83 EESDKIAALDAGADDYLSKPFGIGELQARL-----RVALRRHSATPAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEF 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128961  164 EMLVAFVTNPGEILSRERLL-RMLSARRVENPD-LRtvdVLIRRLRHKLSAD-----LLVTQHGEGY 223
Cdd:PRK10529 158 RLLAVLLNNAGKVLTQRQLLnQVWGPNAVEHSHyLR---IYMGHLRQKLEQDparprHFITETGIGY 221
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-185 8.30e-28

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 105.25  E-value: 8.30e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   1 MPHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERST---VGII 77
Cdd:COG3437   5 QAPTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPStrdIPVI 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961  78 LVTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLwRIDLARQAQPHTQDNCYRFAGY----CLNVSRHTLERdg 153
Cdd:COG3437  85 FLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNAL-ELRRLQRELDDLVLYLKLAAPLhdigKIGIPDAILLK-- 161

                       170       180       190
                ....*....|....*....|....*....|..
gi 16128961 154 ePIKLTRAEYEMLVAFVTNPGEILSRERLLRM 185
Cdd:COG3437 162 -PGKLTPEEWEITHAHIGAEILSGSLLPLLQL 192
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 5-119 1.57e-27

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 101.35  E-value: 1.57e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRSD 84
Cdd:cd17614   1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIMLTAKDS 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16128961  85 RIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWR 119
Cdd:cd17614  81 EVDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 5-117 1.75e-27

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 101.02  E-value: 1.75e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTGRS 83
Cdd:cd17624   1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQgQSLPVLILTARD 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 16128961  84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17624  81 GVDDRVAGLDAGADDYLVKPFALEELLARLRALL 114
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 4-114 1.79e-27

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 101.37  E-value: 1.79e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTG-R 82
Cdd:cd17594   1 HVLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISGdR 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 16128961  83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:cd17594  81 RDEIDRVVGLELGADDYLAKPFGLRELLARVR 112
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
1-223 2.21e-27

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 104.42  E-value: 2.21e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    1 MPHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERST---VGII 77
Cdd:PRK10161   1 MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMtrdIPVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   78 LVTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIdlarqaQPHTQDNCYRFAGYCLNVSRHTLERDGEPIK 157
Cdd:PRK10161  81 MLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRI------SPMAVEEVIEMQGLSLDPTSHRVMAGEEPLE 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961  158 LTRAEYEMLVAFVTNPGEILSRERLLRMLSARRVENPDlRTVDVLIRRLRHKLSAD----LLVTQHGEGY 223
Cdd:PRK10161 155 MGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVED-RTVDVHIRRLRKALEPGghdrMVQTVRGTGY 223
PRK10816 PRK10816
two-component system response regulator PhoP;
5-223 3.92e-27

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 103.67  E-value: 3.92e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTGRS 83
Cdd:PRK10816   3 VLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDvSLPILVLTARE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWR-IDLARQAqphtqdncYRFAGYCLNVSRHTLERDGEPIKLTRAE 162
Cdd:PRK10816  83 SWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRnSGLASQV--------ISLPPFQVDLSRRELSINDEVIKLTAFE 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128961  163 YEMLVAFVTNPGEILSRERLLRMLsarrVENPDLR---TVDVLIRRLRHKLSA----DLLVTQHGEGY 223
Cdd:PRK10816 155 YTIMETLIRNNGKVVSKDSLMLQL----YPDAELReshTIDVLMGRLRKKIQAqypqEVITTVRGQGY 218
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 3-210 1.04e-26

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 102.79  E-value: 1.04e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:PRK10701   2 NKIVFVEDDAEVGSLIAAYLAKHDIDVTVEPRGDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQGPIVLLTSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQ-----PHTQDNCYRFAGYCLN-VSRH-TLerDGEP 155
Cdd:PRK10701  82 DSDMNHILALEMGACDYILKTTPPAVLLARLRLHLRQNEQATQTKglqetSLTPYKALHFGTLTIDpVNRQvTL--AGEE 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 16128961  156 IKLTRAEYEMLVAFVTNPGEILSRERLLRMLSARRVENPDlRTVDVLIRRLRHKL 210
Cdd:PRK10701 160 ISLSTADFDLLWELATHAGQIMDRDALLKNLRGVSYDGLD-RSVDVAISRLRKKL 213
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 4-119 1.45e-26

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 98.98  E-value: 1.45e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRS 83
Cdd:cd19939   1 RILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHVPILMLTART 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16128961  84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWR 119
Cdd:cd19939  81 EEMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 4-117 2.91e-26

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 98.09  E-value: 2.91e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS---TVGIILVT 80
Cdd:cd17618   2 TILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEmtrDIPIIMLT 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17618  82 ARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
PRK15479 PRK15479
transcriptional regulator TctD;
5-225 4.46e-26

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 100.57  E-value: 4.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTGRS 83
Cdd:PRK15479   3 LLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRgQTLPVLLLTARS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHTQDNCYRFAGYCLnvsrhtleRDGEPIKLTRAEY 163
Cdd:PRK15479  83 AVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQQLGELIFHDEGYFL--------LQGQPLALTPREQ 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16128961  164 EMLVAFVTNPGEILSRERLLRMLSARRVE-NPDlrTVDVLIRRLRHKLSAD--LLVTQHGEGYFL 225
Cdd:PRK15479 155 ALLTVLMYRRTRPVSRQQLFEQVFSLNDEvSPE--SIELYIHRLRKKLQGSdvRITTLRGLGYVL 217
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 7-103 7.04e-26

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 96.53  E-value: 7.04e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   7 IVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTGRSDR 85
Cdd:cd00156   2 IVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELpPDIPVIVLTAKADE 81

                        90
                ....*....|....*...
gi 16128961  86 IDRIVGLEMGADDYVTKP 103
Cdd:cd00156  82 EDAVRALELGADDYLVKP 99
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 5-117 2.22e-25

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 95.81  E-value: 2.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRSD 84
Cdd:cd18159   1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISNVPIIFISSRDD 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 16128961  85 RIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd18159  81 NMDQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-128 2.61e-25

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 102.35  E-value: 2.61e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   1 MPHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILV 79
Cdd:COG2204   1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALdPDLPVILL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 16128961  80 TGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQP 128
Cdd:COG2204  81 TGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENAE 129
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 5-103 4.85e-25

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 94.54  E-value: 4.85e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGA-GLREIMQNQSvDLILLDINLPDENGLMLTRALRERSTVGIILVTGRS 83
Cdd:cd17620   1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQeGLLEAATRKP-DLIILDLGLPDMDGLEVIRRLREWSAVPVIVLSARD 79

                        90       100
                ....*....|....*....|
gi 16128961  84 DRIDRIVGLEMGADDYVTKP 103
Cdd:cd17620  80 EESDKIAALDAGADDYLTKP 99
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 5-119 3.44e-24

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 92.83  E-value: 3.44e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGA-GLREIMQNQSvDLILLDINLPDENGLMLTRALRE-RSTVGIILVTGR 82
Cdd:cd17627   1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAeALRVISGNRP-DAVVLDVMMPRLDGLEVCRRLRAaGNDLPILVLTAR 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 16128961  83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWR 119
Cdd:cd17627  80 DSVSDRVAGLDAGADDYLVKPFALEELLARVRALLRR 116
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 7-119 3.71e-24

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 92.67  E-value: 3.71e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   7 IVEDEPVTQARLQSYFTQEGYTVSVTASG-AGLREIMQNQsVDLILLDINLPDENGLMLTRALRE-RSTVGIILVTGRSD 84
Cdd:cd17625   2 VVEDEKDLSEAITKHLKKEGYTVDVCFDGeEGLEYALSGI-YDLIILDIMLPGMDGLEVLKSLREeGIETPVLLLTALDA 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16128961  85 RIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWR 119
Cdd:cd17625  81 VEDRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 3-117 4.05e-24

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 92.44  E-value: 4.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:cd17622   1 TRILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLLTAL 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16128961  83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17622  81 DSDIDHILGLELGADDYVVKPVEPAVLLARLRALL 115
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 5-103 1.50e-23

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 90.72  E-value: 1.50e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASG-AGLREIMQNqSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRS 83
Cdd:cd17621   1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGpAALAEFDRA-GADIVLLDLMLPGLSGTEVCRQLRARSNVPVIMVTAKD 79

                        90       100
                ....*....|....*....|
gi 16128961  84 DRIDRIVGLEMGADDYVTKP 103
Cdd:cd17621  80 SEIDKVVGLELGADDYVTKP 99
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 5-103 3.92e-23

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 89.42  E-value: 3.92e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGA-GLREIMQNqSVDLILLDINLPDENGLMLTRALRER-STVGIILVTGR 82
Cdd:cd19935   1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEdGLHLALTN-EYDLIILDVMLPGLDGLEVLRRLRAAgKQTPVLMLTAR 79

                        90       100
                ....*....|....*....|.
gi 16128961  83 SDRIDRIVGLEMGADDYVTKP 103
Cdd:cd19935  80 DSVEDRVKGLDLGADDYLVKP 100
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 4-103 9.77e-23

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 88.71  E-value: 9.77e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVG---IILVT 80
Cdd:cd17538   1 KILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRhipVIMIT 80

                        90       100
                ....*....|....*....|...
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKP 103
Cdd:cd17538  81 ALDDREDRIRGLEAGADDFLSKP 103
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-127 4.95e-22

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 87.72  E-value: 4.95e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   1 MPHHIVIVEDEPVTQARLQSYFTQ-EGYTVSVTA-SGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGII 77
Cdd:COG4565   2 KMIRVLIVEDDPMVAELLRRYLERlPGFEVVGVAsSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARgPDVDVI 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 16128961  78 LVTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQ 127
Cdd:COG4565  82 VITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQ 131
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 142-225 8.65e-22

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 85.61  E-value: 8.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961 142 LNVSRHTLERDGEPIKLTRAEYEMLVAFVTNPGEILSRERLLRMLSARRVEnPDLRTVDVLIRRLRHKLSAD----LLVT 217
Cdd:cd00383   3 LDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYE-VDDRTVDVHISRLRKKLEDDpeprLIKT 81


                ....*...
gi 16128961 218 QHGEGYFL 225
Cdd:cd00383  82 VRGVGYRL 89
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 5-119 1.85e-21

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 85.87  E-value: 1.85e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERST-VGIILVTGRS 83
Cdd:cd17615   2 VLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPdVPVLFLTAKD 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16128961  84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWR 119
Cdd:cd17615  82 SVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRR 117
PRK10336 PRK10336
two-component system response regulator QseB;
5-225 3.67e-21

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 87.64  E-value: 3.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILV-TGRS 83
Cdd:PRK10336   3 ILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLIlTARD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLwridlaRQAQPHTQdNCYRFAGYCLNVSRHTLERDGEPIKLTRAEY 163
Cdd:PRK10336  83 ALAERVEGLRLGADDYLCKPFALIEVAARLEALM------RRTNGQAS-NELRHGNVMLDPGKRIATLAGEPLTLKPKEF 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16128961  164 EMLVAFVTNPGEILSRERLLRMLSARRvENPDLRTVDVLIRRLRHKLSADLLVTQHGEGYFL 225
Cdd:PRK10336 156 ALLELLMRNAGRVLPRKLIEEKLYTWD-EEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTL 216
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 5-103 1.10e-20

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 83.26  E-value: 1.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRSD 84
Cdd:cd19936   1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTLPVIFLTSKDD 80

                        90
                ....*....|....*....
gi 16128961  85 RIDRIVGLEMGADDYVTKP 103
Cdd:cd19936  81 EIDEVFGLRMGADDYITKP 99
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 5-109 1.85e-20

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 82.90  E-value: 1.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRE----RSTVGIILVT 80
Cdd:cd17546   1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIREleggGRRTPIIALT 80

                        90       100
                ....*....|....*....|....*....
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKPLELREL 109
Cdd:cd17546  81 ANALEEDREKCLEAGMDDYLSKPVKLDQL 109
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 5-114 2.82e-20

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 82.52  E-value: 2.82e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRSD 84
Cdd:cd17626   3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVMLTAKSD 82

                        90       100       110
                ....*....|....*....|....*....|
gi 16128961  85 RIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:cd17626  83 TVDVVLGLESGADDYVAKPFKPKELVARIR 112
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 5-119 3.65e-20

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 82.33  E-value: 3.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTGRS 83
Cdd:cd19934   1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGrATPVLILTARD 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16128961  84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWR 119
Cdd:cd19934  81 SWQDKVEGLDAGADDYLTKPFHIEELLARLRALIRR 116
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 4-116 1.60e-19

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 80.56  E-value: 1.60e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYT-VSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER---STVGIILV 79
Cdd:cd17551   2 RILIVDDNPTNLLLLEALLRSAGYLeVVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALpglEDVPIVMI 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 16128961  80 TGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNL 116
Cdd:cd17551  82 TADTDREVRLRALEAGATDFLTKPFDPVELLARVRNL 118
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 5-114 2.98e-19

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 79.76  E-value: 2.98e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALR-ERSTVGIILVTGRS 83
Cdd:cd17616   1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRlAKVKTPILILSGLA 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 16128961  84 DRIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:cd17616  81 DIEDKVKGLGFGADDYMTKPFHKDELVARIH 111
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 5-103 5.10e-19

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 78.71  E-value: 5.10e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASG-AGLREIMQNQSvDLILLDINLPDENGLMLTRALRER-STVGI--ILVT 80
Cdd:cd19920   1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGqQALQRAQAEPP-DLILLDVMMPGMDGFEVCRRLKADpATRHIpvIFLT 79

                        90       100
                ....*....|....*....|...
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKP 103
Cdd:cd19920  80 ALTDTEDKVKGFELGAVDYITKP 102
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
153-225 2.76e-18

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 76.01  E-value: 2.76e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128961   153 GEPIKLTRAEYEMLVAFVTNPGEILSRERLLRMLSARRVEnPDLRTVDVLIRRLRHKLSAD-----LLVTQHGEGYFL 225
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYD-VDDNTVDVHISRLRKKLEDDprdprLIKTVRGVGYRL 77
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 5-103 5.33e-18

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 75.97  E-value: 5.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQE-GYTVSVTA-SGA-GLrEIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVT 80
Cdd:COG4753   2 VLIVDDEPLIREGLKRILEWEaGFEVVGEAeNGEeAL-ELLEEHKPDLVITDINMPGMDGLELLEAIRELDpDTKIIILS 80

                        90       100
                ....*....|....*....|...
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKP 103
Cdd:COG4753  81 GYSDFEYAQEAIKLGADDYLLKP 103
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 5-117 9.02e-18

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 76.21  E-value: 9.02e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPvTQA-RLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER---STVGIILVT 80
Cdd:cd17598   1 ILIVEDSP-TQAeQLKHILEEQGYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDpdlKDIPVILLT 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17598  80 TLSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYIL 116
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 153-225 2.70e-17

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 73.36  E-value: 2.70e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128961    153 GEPIKLTRAEYEMLVAFVTNPGEILSRERLLRMLSARRVEnPDLRTVDVLIRRLRHKLSAD----LLVTQHGEGYFL 225
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDED-VDDNTLDVHISRLRKKLEDDgdprLIETVRGVGYRL 76
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 5-117 7.21e-17

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 73.77  E-value: 7.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTGRS 83
Cdd:cd17572   1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSlPTSVIVITAHG 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16128961  84 DrIDRIV-GLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17572  81 S-VDIAVeAMRLGAYDFLEKPFDADRLRVTVRNAL 114
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
134-230 8.32e-17

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 73.01  E-value: 8.32e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961 134 CYRFAGYCLNVSRHTLERDGEPIKLTRAEYEMLVAFVTNPGEILSRERLLRMLSARRVENPDlrTVDVLIRRLRHKL--- 210
Cdd:COG3710   2 RYRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDN--SLTQAISRLRKALgdd 79

                        90       100
                ....*....|....*....|..
gi 16128961 211 --SADLLVTQHGEGYFLAADVC 230
Cdd:COG3710  80 glEPRLIRTVPRRGYRLVAPVE 101
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 5-103 1.95e-16

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 72.03  E-value: 1.95e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER---STVGIILVTG 81
Cdd:cd19927   1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNadfDTIPVIFLTA 80

                        90       100
                ....*....|....*....|..
gi 16128961  82 RSDRIDRIVGLEMGADDYVTKP 103
Cdd:cd19927  81 KGMTSDRIKGYNAGCDGYLSKP 102
pleD PRK09581
response regulator PleD; Reviewed
 1-117 3.22e-16

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 76.86  E-value: 3.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    1 MPHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERST---VGII 77
Cdd:PRK09581   1 MTARILVVDDIPANVKLLEAKLLAEYYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSDPAtthIPVV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 16128961   78 LVTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:PRK09581  81 MVTALDDPEDRVRGLEAGADDFLTKPINDVALFARVKSLT 120
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 5-109 3.51e-16

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 71.67  E-value: 3.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTA-SGAGLREIMQNQSVDLILLDINLPDE-NGLMLTRALRERSTVGIILVTGR 82
Cdd:cd17534   3 ILIVEDEAIIALDLKEILESLGYEVVGIAdSGEEAIELAEENKPDLILMDINLKGDmDGIEAAREIREKFDIPVIFLTAY 82

                        90       100
                ....*....|....*....|....*....
gi 16128961  83 SDR--IDRIVGLEmgADDYVTKPLELREL 109
Cdd:cd17534  83 SDEetLERAKETN--PYGYLVKPFNEREL 109
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 5-114 4.40e-16

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 71.42  E-value: 4.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER---STVGIILVTG 81
Cdd:cd17548   2 ILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEDpatRDIPVIALTA 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16128961  82 ---RSDRiDRIvgLEMGADDYVTKPLELRELVVRVK 114
Cdd:cd17548  82 yamKGDR-EKI--LEAGCDGYISKPIDTREFLETVA 114
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 4-110 9.48e-16

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 72.26  E-value: 9.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERST-VGIILVTGR 82
Cdd:COG4567   6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPdARIVVLTGY 85

                        90       100
                ....*....|....*....|....*....
gi 16128961  83 SDrIDRIVGL-EMGADDYVTKPLELRELV 110
Cdd:COG4567  86 AS-IATAVEAiKLGADDYLAKPADADDLL 113
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 5-110 1.58e-15

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 69.79  E-value: 1.58e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVG---IILVTG 81
Cdd:cd17580   1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLAntpAIALTG 80

                        90       100
                ....*....|....*....|....*....
gi 16128961  82 RSDRIDRIVGLEMGADDYVTKPLELRELV 110
Cdd:cd17580  81 YGQPEDRERALEAGFDAHLVKPVDPDELI 109
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 5-105 1.99e-15

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 69.92  E-value: 1.99e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASG-AGLrEIMQNQSVDLILLDINLPDENGLMLTRALRERST-VGIILVTGR 82
Cdd:cd17555   3 ILVIDDDEVVRESIAAYLEDSGFQVLQAADGrQGL-ELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPdTPVIVVSGA 81

                        90       100
                ....*....|....*....|...
gi 16128961  83 SDRIDRIVGLEMGADDYVTKPLE 105
Cdd:cd17555  82 GVMSDAVEALRLGAWDYLTKPIE 104
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 4-133 3.31e-15

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 71.77  E-value: 3.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQ-EGYT-VSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERST-VGIILVT 80
Cdd:COG3279   3 KILIVDDEPLARERLERLLEKyPDLEvVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPpPPIIFTT 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 16128961  81 GRSDR-IDrivGLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHTQDN 133
Cdd:COG3279  83 AYDEYaLE---AFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEK 133
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 4-110 8.59e-15

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 67.85  E-value: 8.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTGR 82
Cdd:cd17563   2 SLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQpDARIVVLTGY 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 16128961  83 SD---RIDRIvglEMGADDYVTKPLELRELV 110
Cdd:cd17563  82 ASiatAVEAI---KLGADDYLAKPADADEIL 109
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 4-109 1.10e-14

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 68.04  E-value: 1.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQ-EGYTVSVTA-SGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVT 80
Cdd:cd19925   2 NVLIVEDDPMVAEIHRAYVEQvPGFTVIGTAgTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGhDVDVIVVT 81

                        90       100
                ....*....|....*....|....*....
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKPLELREL 109
Cdd:cd19925  82 AANDVETVREALRLGVVDYLIKPFTFERL 110
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 4-116 1.03e-13

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 65.32  E-value: 1.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTGR 82
Cdd:cd17554   2 KILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKkPDLPVIICTAY 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 16128961  83 SDRIDrivglEMG---ADDYVTKPLELRELVVRVKNL 116
Cdd:cd17554  82 SEYKS-----DFSswaADAYVVKSSDLTELKETIKRL 113
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 5-110 5.15e-13

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 65.36  E-value: 5.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTA-SGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRS 83
Cdd:COG3707   6 VLVVDDEPLRRADLREGLREAGYEVVAEAaDGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLTAYS 85

                        90       100
                ....*....|....*....|....*....
gi 16128961  84 DR--IDRIVglEMGADDYVTKPLELRELV 110
Cdd:COG3707  86 DPelIERAL--EAGVSAYLVKPLDPEDLL 112
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 5-110 5.71e-13

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 63.30  E-value: 5.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYF-TQEGYTVSVTA-SGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTG 81
Cdd:cd17535   1 VLIVDDHPLVREGLRRLLeSEPDIEVVGEAaDGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRyPDLKVIVLTA 80

                        90       100
                ....*....|....*....|....*....
gi 16128961  82 RSDRIDRIVGLEMGADDYVTKPLELRELV 110
Cdd:cd17535  81 HDDPEYVLRALKAGAAGYLLKDSSPEELI 109
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 5-117 5.92e-13

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 63.28  E-value: 5.92e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTGRS 83
Cdd:cd17550   1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYpDLPVIMISGHG 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16128961  84 DrIDRIV-GLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17550  81 T-IETAVkATKLGAYDFIEKPLSLDRLLLTIERAL 114
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 5-103 7.02e-13

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 62.77  E-value: 7.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTV-SVTASGAGLREIMQNQSvDLILLDINLPDENGLMLTRALRERS---TVGIILVT 80
Cdd:cd17602   1 VACVDDRPSIQKMIEYFLEKQGFRVvVIDDPLRALTTLLNSKP-DLILIDIDMPDLDGYELCSLLRKSSalkDTPIIMLT 79

                        90       100
                ....*....|....*....|...
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKP 103
Cdd:cd17602  80 GKDGLVDRIRAKMAGASGYLTKP 102
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 5-117 1.13e-12

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 62.35  E-value: 1.13e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQE--GYTVSVTAS-GA-GLrEIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILV 79
Cdd:cd17536   1 VLIVDDEPLIREGLKKLIDWEelGFEVVGEAEnGEeAL-ELIEEHKPDIVITDIRMPGMDGLELIEKIRELYpDIKIIIL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 16128961  80 TGRSD-----RidrivGLEMGADDYVTKPL---ELRELVVRVKNLL 117
Cdd:cd17536  80 SGYDDfeyaqK-----AIRLGVVDYLLKPVdeeELEEALEKAKEEL 120
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 5-117 1.70e-12

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 61.91  E-value: 1.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTAS-GAGLREIMQNQSVDLILLDINLPDENGLMLTRALRE-RSTVGIILVTGR 82
Cdd:cd17542   3 VLIVDDAAFMRMMLKDILTKAGYEVVGEAAnGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKiDPNAKVIMCSAM 82

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16128961  83 SDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17542  83 GQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-138 1.90e-12

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 63.58  E-value: 1.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTGR 82
Cdd:COG4566   1 TVYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARgSPLPVIFLTGH 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 16128961  83 SDrIDRIV-GLEMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQPHTQDNCYRFA 138
Cdd:COG4566  81 GD-VPMAVrAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAELRARLA 136
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
5-133 4.38e-12

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 64.87  E-value: 4.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERST-VGIILVTGRS 83
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETrTPVILMTAYA 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELvvrvkNLLwrIDLARQAQPHTQDN 133
Cdd:PRK11361  87 EVETAVEALRCGAFDYVIKPFDLDEL-----NLI--VQRALQLQSMKKEI 129
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 2-117 5.49e-12

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 60.64  E-value: 5.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   2 PHHIVIVEDEP----VTQARLQsyfTQEGYTVSVTASGA-GLrEIMQNQSVDLILLDINLPDENGLMLTRALRERS---T 73
Cdd:cd17552   1 SKRILVIDDEEdireVVQACLE---KLAGWEVLTASSGQeGL-EKAATEQPDAILLDVMMPDMDGLATLKKLQANPetqS 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 16128961  74 VGIILVTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17552  77 IPVILLTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIAKLL 120
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 5-113 1.97e-11

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 58.98  E-value: 1.97e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTAS---GAGLREImqnQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVT 80
Cdd:cd17573   1 ILLIEDDSTLGKEISKGLNEKGYQADVAESlkdGEYYIDI---RNYDLVLVSDKLPDGNGLSIVSRIKEKHpSIVVIVLS 77

                        90       100       110
                ....*....|....*....|....*....|...
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKPLELRELVVRV 113
Cdd:cd17573  78 DNPKTEQEIEAFKEGADDYIAKPFDFKVLVARI 110
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 4-117 3.38e-11

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 58.47  E-value: 3.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASG-AGLREImQNQSVDLILLDINLPDENGLMLTRALRERST---VGIILV 79
Cdd:cd17562   2 KILAVDDSASIRQMVSFTLRGAGYEVVEAADGrDALSKA-QSKKFDLIITDQNMPNMDGIELIKELRKLPAykfTPILML 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 16128961  80 TGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17562  81 TTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 5-103 1.89e-10

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 56.23  E-value: 1.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASG-------AGLREIMQNQS--VDLILLDINLPDENGLMLTRALRER---S 72
Cdd:cd19924   1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGeealnklENLAKEGNDLSkeLDLIITDIEMPKMDGYELTFELRDDprlA 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 16128961  73 TVGIILVTGRSDRIDRIVGLEMGADDYVTKP 103
Cdd:cd19924  81 NIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 5-117 2.40e-10

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 56.34  E-value: 2.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTGRS 83
Cdd:cd17549   1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELdPDLPVILITGHG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 16128961  84 DrIDRIV-GLEMGADDYVTKP-------------LELRELVVRVKNLL 117
Cdd:cd17549  81 D-VPMAVeAMRAGAYDFLEKPfdperlldvvrraLEKRRLVLENRRLR 127
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 4-57 3.83e-10

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 53.73  E-value: 3.83e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16128961      4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLP 57
Cdd:smart00448   2 RILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 5-103 4.59e-10

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 54.82  E-value: 4.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGL-MLTRALRERSTVGIILVTGRS 83
Cdd:cd19928   1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLdLIPRIKKARPDLPIIVMSAQN 80

                        90       100
                ....*....|....*....|
gi 16128961  84 DRIDRIVGLEMGADDYVTKP 103
Cdd:cd19928  81 TLMTAVKAAERGAFEYLPKP 100
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 5-117 4.64e-10

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 55.42  E-value: 4.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYT-VSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALR---ERSTVGIILVT 80
Cdd:cd19923   3 VLVVDDFSTMRRIIKNLLKELGFNnVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRadgALSHLPVLMVT 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd19923  83 AEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKIF 119
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 5-127 6.62e-10

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 55.45  E-value: 6.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFtQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER--STVGIILvTGR 82
Cdd:cd17596   3 ILVVDDEVRSLEALRRTL-EEDFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERwpEVVRIII-SGY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 16128961  83 SDRIDRIVGL-EMGADDYVTKPLELRELVVRVKNLLWRIDLARQAQ 127
Cdd:cd17596  81 TDSEDIIAGInEAGIYQYLTKPWHPDQLLLTVRNAARLFELQRENE 126
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 5-109 7.48e-10

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 54.94  E-value: 7.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQ--SVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:cd17584   1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENkdEFDLVITDVHMPDMDGFEFLELIRLEMDLPVIMMSAD 80

                        90       100
                ....*....|....*....|....*..
gi 16128961  83 SDRIDRIVGLEMGADDYVTKPLELREL 109
Cdd:cd17584  81 GSTSTVMKGLAHGACDYLLKPVSIEDL 107
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
 5-114 7.73e-10

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 55.01  E-value: 7.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEgYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALR--ERS-TVGIILVTG 81
Cdd:cd17539   1 VLLVDDRPSSAERIAAMLSSE-HEVVVEADPDEALFRAAEGPFDLVIVSLALEDFDGLRLCSQLRslERTrQLPILAVAD 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 16128961  82 RSDRIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:cd17539  80 PGDRGRLIRALEIGVNDYLVRPIDPNELLARVR 112
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 5-117 1.06e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 54.94  E-value: 1.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQS----YFTQEG--YTVSVTASGAGLRE---IMQNQSVDLILLDINLPDENGLMLTRALRERSTVG 75
Cdd:cd17533   3 IFILEDDKIQRVRLEEiienILKIENieYVIELTGKTEELLEkikERGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDPYA 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 16128961  76 -IILVTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17533  83 iIIFVTTHSEFAPLTFEYKVAALDFILKPLKLEEFKKRIEECI 125
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 3-113 2.24e-09

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 53.68  E-value: 2.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASG-AGLREIMQNQSVDLILLDINLPDENGLMLTRALRE---RSTVGIIL 78
Cdd:cd17544   1 IKVLVVDDSATSRNHLRALLRRHNFQVLEAANGqEALEVLEQHPDIKLVITDYNMPEMDGFELVREIRKkysRDQLAIIG 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16128961  79 VTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRV 113
Cdd:cd17544  81 ISASGDNALSARFIKAGANDFLTKPFLPEEFYCRV 115
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 5-117 2.84e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 53.31  E-value: 2.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLqSYFTQEGYTVSVTASGA----GLREIMQNQsVDLILLDINLPDENGLMLTRALRERSTVG-IILV 79
Cdd:cd17532   1 ALIVDDEPLAREEL-RYLLEEHPDIEIVGEAEngeeALEAIEELK-PDVVFLDIQMPGLDGLELAKKLSKLAKPPlIVFV 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 16128961  80 TG-RSDRIDrivGLEMGADDYVTKPLE---LRELVVRVKNLL 117
Cdd:cd17532  79 TAyDEYAVE---AFELNAVDYLLKPFSeerLAEALAKLRKRL 117
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 3-117 6.21e-09

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 52.41  E-value: 6.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGA-GLrEIMQNQSVDLILLDINLPDENGLMLTRALRERS--TVGIILv 79
Cdd:cd17569   1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEeAL-EILKQEPVDVVISDQRMPGMDGAELLKRVRERYpdTVRILL- 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 16128961  80 TGRSD-----------RIDRivglemgaddYVTKPLELRELVVRVKNLL 117
Cdd:cd17569  79 TGYADldaaieainegEIYR----------FLTKPWDDEELKETIRQAL 117
pleD PRK09581
response regulator PleD; Reviewed
 4-114 7.10e-09

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 55.29  E-value: 7.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNqSVDLILLDINLPDENGLMLTRALR---ERSTVGIILVT 80
Cdd:PRK09581 157 RILLVDDDVSQAERIANILKEEFRVVVVSDPSEALFNAAET-NYDLVIVSANFENYDPLRLCSQLRskeRTRYVPILLLV 235

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 16128961   81 GRSDRiDRIV-GLEMGADDYVTKPLELRELVVRVK 114
Cdd:PRK09581 236 DEDDD-PRLVkALELGVNDYLMRPIDKNELLARVR 269
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 48-116 1.45e-08

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 51.65  E-value: 1.45e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128961  48 DLILLDINLPDENGLMLTRALRE----RSTVGIILVTGRSDRiDRIVGLEMGADDYVTKPLELRELVVRVKNL 116
Cdd:cd17557  54 DLILLDLNMPRMDGFEVLREIKAdpdlRRIPVVVLTTSDAEE-DIERAYELGANSYIVKPVDFEEFVEAIRSL 125
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 5-114 2.43e-08

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 50.73  E-value: 2.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTGRS 83
Cdd:cd19919   3 VWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRhPDLPVIIMTAHS 82

                        90       100       110
                ....*....|....*....|....*....|.
gi 16128961  84 DRIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:cd19919  83 DLDSAVSAYQGGAFEYLPKPFDIDEAVALVE 113
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 5-103 2.60e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 50.85  E-value: 2.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQE-GYTVSVTAS-GAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:cd17541   3 VLIVDDSAVMRKLLSRILESDpDIEVVGTARdGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERPTPVVMVSSL 82

                        90       100
                ....*....|....*....|...
gi 16128961  83 SDRIDRIV--GLEMGADDYVTKP 103
Cdd:cd17541  83 TEEGAEITleALELGAVDFIAKP 105
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 5-81 2.62e-08

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 50.19  E-value: 2.62e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIM-QNQSVDLILLDINLPDENGLMLTRALRE-RSTVGIILVTG 81
Cdd:cd18160   2 ILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLqQGKDIDIVVTDIVMPEMDGIELAREARKiDPDVKILFISG 80
PRK13557 PRK13557
histidine kinase; Provisional
 4-117 2.87e-08

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 53.52  E-value: 2.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    4 HIVIVEDEP----VTQARLQSYftqeGYTVSVTASGAGLREIMQNQS-VDLILLDINLPDE-NGLMLTRALRER-STVGI 76
Cdd:PRK13557 417 TILIVDDRPdvaeLARMILEDF----GYRTLVASNGREALEILDSHPeVDLLFTDLIMPGGmNGVMLAREARRRqPKIKV 492

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 16128961   77 ILVTGRSD----RIDrIVGLEMgadDYVTKPLELRELVVRVKNLL 117
Cdd:PRK13557 493 LLTTGYAEasieRTD-AGGSEF---DILNKPYRRAELARRVRMVL 533
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
5-116 3.12e-08

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 53.58  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961     5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTGRS 83
Cdd:PRK09959  961 ILIADDHPTNRLLLKRQLNLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQnSSLPIWGLTANA 1040

                          90       100       110
                  ....*....|....*....|....*....|...
gi 16128961    84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNL 116
Cdd:PRK09959 1041 QANEREKGLSCGMNLCLFKPLTLDVLKTHLSQL 1073
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 4-133 3.54e-08

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 53.41  E-value: 3.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    4 HIVIVEDEP--VTQARlqSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVG----II 77
Cdd:PRK11091 527 NILLVEDIElnVIVAR--SVLEKLGNSVDVAMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELRERYPREdlppLV 604

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 16128961   78 LVTG--RSDRIDRivgLEMGADDYVTKPLELRELvVRVKNLLWRIDLARQAQPHTQDN 133
Cdd:PRK11091 605 ALTAnvLKDKKEY---LDAGMDDVLSKPLSVPAL-TAMIKKFWDTQDDEESTVTTEES 658
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 5-124 4.28e-08

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 50.10  E-value: 4.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTAS-GAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRS 83
Cdd:cd19932   3 VLIAEDEALIRMDLREMLEEAGYEVVGEASdGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVLLTAYS 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 16128961  84 DRIDRIVGLEMGADDYVTKPlelrelvVRVKNLLWRIDLAR 124
Cdd:cd19932  83 QQDLVERAKEAGAMAYLVKP-------FSESDLIPAIEMAI 116
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 2-71 8.31e-08

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 49.51  E-value: 8.31e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16128961   2 PHHIVIVEDEPVTQARLQSYF-TQEGYTVSVTA-SGAGLREIMQNQSVDLILLDINLPDENGLMLTRAL---RER 71
Cdd:COG2197   1 MIRVLIVDDHPLVREGLRALLeAEPDIEVVGEAaDGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLltpRER 75
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 5-113 9.88e-08

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 48.80  E-value: 9.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYT-VSVTASGAGLREIMQNQSVDLILLDINLPD-ENGLMLTRALRE-----RSTVgII 77
Cdd:cd17589   1 FLIVDDQPTFRSMLKSMLRSLGVTrIDTASSGEEALRMCENKTYDIVLCDYNLGKgKNGQQLLEELRHkklisPSTV-FI 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16128961  78 LVTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRV 113
Cdd:cd17589  80 MVTGESSRAMVLSALELEPDDYLLKPFTVSELRERL 115
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 48-110 1.38e-07

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 50.41  E-value: 1.38e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16128961   48 DLILLDINLPDENGLMLTRALRERSTVGIILVTGRSDRIDRIV-GLEMGADDYVTKPLELRELV 110
Cdd:PRK10651  54 DLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSVSNHEEDVVtALKRGADGYLLKDMEPEDLL 117
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 5-117 1.46e-07

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 48.70  E-value: 1.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRE-RSTVGIILVT--G 81
Cdd:cd17553   3 ILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKViDENIRVIIMTayG 82

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16128961  82 RSDRIDRivGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd17553  83 ELDMIQE--SKELGALTHFAKPFDIDEIRDAVKKYL 116
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 5-117 1.91e-07

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 48.11  E-value: 1.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGY--TVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:cd19931   1 VLLIDDHPLLRKGIKQLIELDPDftVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTV 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16128961  83 SD-RIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:cd19931  81 SDaEDDVVTALRAGADGYLLKDMEPEDLLEALKQAA 116
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 5-133 5.57e-07

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 49.48  E-value: 5.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTGRS 83
Cdd:PRK10923   6 VWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHpMLPVIIMTAHS 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELRELVVRVKNLLWRidLARQAQPHTQDN 133
Cdd:PRK10923  86 DLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISH--YQEQQQPRNIQV 133
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
4-109 1.26e-06

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 48.82  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVTGR 82
Cdd:PRK10841 803 MILVVDDHPINRRLLADQLGSLGYQCKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGlTLPVIGVTAN 882

                         90       100
                 ....*....|....*....|....*..
gi 16128961   83 SDRIDRIVGLEMGADDYVTKPLELREL 109
Cdd:PRK10841 883 ALAEEKQRCLEAGMDSCLSKPVTLDVL 909
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 5-103 1.56e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 45.42  E-value: 1.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGA-GLREIMQNQSVDLILLDINLPDE-NGLMLTRALRE-RSTVGIILVTG 81
Cdd:cd18161   1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDeALDLLESGPDIDLLVTDVIMPGGmNGSQLAEEARRrRPDLKVLLTSG 80

                        90       100
                ....*....|....*....|..
gi 16128961  82 RSDRIDRIVGLEMGAdDYVTKP 103
Cdd:cd18161  81 YAENAIEGGDLAPGV-DVLSKP 101
PRK10430 PRK10430
two-component system response regulator DcuR;
5-105 1.97e-06

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 47.41  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQ-EGYTVSVTASG-AGLREIMQN--QSVDLILLDINLPDENGLMLTRALRE-RSTVGIILV 79
Cdd:PRK10430   4 VLIVDDDAMVAELNRRYVAQiPGFQCCGTASTlEQAKEIIFNsdTPIDLILLDIYMQQENGLDLLPVLHEaGCKSDVIVI 83

                         90       100
                 ....*....|....*....|....*.
gi 16128961   80 TGRSDRIDRIVGLEMGADDYVTKPLE 105
Cdd:PRK10430  84 SSAADAATIKDSLHYGVVDYLIKPFQ 109
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 3-114 4.56e-06

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 44.51  E-value: 4.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   3 HHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVTG 81
Cdd:cd17537   1 ATVYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARgSNIPIIFITG 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 16128961  82 RSDRIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:cd17537  81 HGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIE 113
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
6-102 4.94e-06

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 45.66  E-value: 4.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    6 VIVEDEPVTQARLQSYFTQEGYTVSVT-ASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVG-IILVTGRS 83
Cdd:PRK09958   4 IIIDDHPLAIAAIRNLLIKNDIEILAElTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGiIIIVSAKN 83

                         90
                 ....*....|....*....
gi 16128961   84 DRIDRIVGLEMGADDYVTK 102
Cdd:PRK09958  84 DHFYGKHCADAGANGFVSK 102
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
5-109 7.84e-06

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 46.18  E-value: 7.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRE-RSTVGIILVTGRS 83
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKAlNPAIPVLIMTAYS 87

                         90       100
                 ....*....|....*....|....*.
gi 16128961   84 DRIDRIVGLEMGADDYVTKPLELREL 109
Cdd:PRK10365  88 SVETAVEALKTGALDYLIKPLDFDNL 113
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 28-112 1.12e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 45.61  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   28 TVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRE----RSTvGIILVT-----GRSDRIdrivgLEMGADD 98
Cdd:PRK11107 693 HVVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRACELIRQlphnQNT-PIIAVTahamaGERERL-----LSAGMDD 766

                         90
                 ....*....|....*..
gi 16128961   99 YVTKPLE---LRELVVR 112
Cdd:PRK11107 767 YLAKPIDeamLKQVLLR 783
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 5-103 1.90e-05

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 42.14  E-value: 1.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER---STVGIILVTG 81
Cdd:cd19926   1 VLVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRlpqTPVAVITAYG 80

                        90       100
                ....*....|....*....|..
gi 16128961  82 RSDriDRIVGLEMGADDYVTKP 103
Cdd:cd19926  81 SLD--TAIEALKAGAFDFLTKP 100
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 5-114 1.92e-05

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 44.74  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961     5 IVIVEDEPVTQARLQSYFtqEGYTVSVTASGAGLREIMQNQSVDLILLDINLP-DENG-----LMLTRALRERSTVGIIL 78
Cdd:TIGR02915   1 LLIVEDDLGLQKQLKWSF--ADYELAVAADRESAIALVRRHEPAVVTLDLGLPpDADGaseglAALQQILAIAPDTKVIV 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 16128961    79 VTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVK 114
Cdd:TIGR02915  79 ITGNDDRENAVKAIGLGAYDFYQKPIDPDVLKLIVD 114
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
 5-86 2.20e-05

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 42.45  E-value: 2.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGA--GLREIMQNQsVDLILLDINLPDENGLMLTRALRERStVGIILVTGR 82
Cdd:cd17586   1 VLVLEDEPLIAMNLEDALEDLGGKEVVTAATCaeALRSLADGP-IDIAILDVNLGGETSIPVADALKRRA-IPFIFATGY 78


                ....
gi 16128961  83 SDRI 86
Cdd:cd17586  79 GDSH 82
PRK15115 PRK15115
response regulator GlrR; Provisional
 2-109 2.27e-05

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 44.83  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    2 PHHIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERST-VGIILVT 80
Cdd:PRK15115   5 PAHLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPgMPVIILT 84

                         90       100
                 ....*....|....*....|....*....
gi 16128961   81 GRSDRIDRIVGLEMGADDYVTKPLELREL 109
Cdd:PRK15115  85 AHGSIPDAVAATQQGVFSFLTKPVDRDAL 113
dpiA PRK10046
two-component response regulator DpiA; Provisional
 2-135 3.16e-05

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 43.47  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    2 PHHIVIVEDEPVTQARLQSYFTQ-EGYT-VSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRE-RSTVGIIL 78
Cdd:PRK10046   4 PLTLLIVEDETPLAEMHAEYIRHiPGFSqILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQaHYPGDVVF 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16128961   79 VTGRSDRIDRIVGLEMGADDYVTKPL---ELRELVVRV---KNLLWRIDLARQAQPHTQDNCY 135
Cdd:PRK10046  84 TTAASDMETVSEAVRCGVFDYLIKPIayeRLGQTLTRFrqrKHMLESIDSASQKQIDEMFNAY 146
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 5-103 5.75e-05

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 41.05  E-value: 5.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYF-TQEGYTVSVTAS-GAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER---STVGIILV 79
Cdd:cd17561   4 VLIADDNREFVQLLEEYLnSQPDMEVVGVAHnGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMrleKRPKIIML 83

                        90       100
                ....*....|....*....|....*.
gi 16128961  80 T--GRSDRIDRIVglEMGADDYVTKP 103
Cdd:cd17561  84 TafGQEDITQRAV--ELGASYYILKP 107
PRK10693 PRK10693
two-component system response regulator RssB;
40-110 6.89e-05

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 43.06  E-value: 6.89e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16128961   40 EIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRSDR---IDRIvgLEMGADDYVTKPL----ELRELV 110
Cdd:PRK10693  11 ELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENmadIAKA--LRLGVQDVLLKPVkdlnRLREMV 86
PRK14084 PRK14084
DNA-binding response regulator;
5-107 1.01e-04

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 42.05  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQsYFTQEGYTVSVTASGAGLREIMQN---QSVDLILLDINLPDENGLMLTRALRERSTVGIILVTG 81
Cdd:PRK14084   3 ALIVDDEPLARNELT-YLLNEIGGFEEINEAENVKETLEAlliNQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFAT 81

                         90       100
                 ....*....|....*....|....*.
gi 16128961   82 RSDRIdRIVGLEMGADDYVTKPLELR 107
Cdd:PRK14084  82 AHDQF-AVKAFELNATDYILKPFEQK 106
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 5-110 1.23e-04

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 40.33  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIM--QNQSVDLILLDINLPDENGLMLTRALRER-STVGIILVT- 80
Cdd:cd19930   1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRlvLKHSPDVAILDIEMPGRTGLEVAAELREElPDTKVLIVTt 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 16128961  81 -GRSDRIDRivGLEMGADDYVTKPLELRELV 110
Cdd:cd19930  81 fGRPGYFRR--ALAAGVDGYVLKDRPIEELA 109
PRK15347 PRK15347
two component system sensor kinase;
4-109 1.46e-04

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 42.32  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    4 HIVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRALRER-----STVGIIL 78
Cdd:PRK15347 692 QILLVDDVETNRDIIGMMLVELGQQVTTAASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQLWRDDpnnldPDCMIVA 771

                         90       100       110
                 ....*....|....*....|....*....|.
gi 16128961   79 VTGRSDRIDRIVGLEMGADDYVTKPLELREL 109
Cdd:PRK15347 772 LTANAAPEEIHRCKKAGMNHYLTKPVTLAQL 802
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 5-85 1.53e-04

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 39.92  E-value: 1.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAG-LREIMQNQSVDLILLDINLPD-ENGLMLTRALRERSTVGIILVTGR 82
Cdd:cd17540   3 VLIIEDEPLIAMDLEQIVEDLGHQVVGIARTRDeAVALARRERPDLILADIQLADgSSGIDAVNEILTTHDVPVIFVTAY 82


                ...
gi 16128961  83 SDR 85
Cdd:cd17540  83 PER 85
PRK07239 PRK07239
bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated
 128-228 1.63e-04

bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated


Pssm-ID: 235981 [Multi-domain]  Cd Length: 381  Bit Score: 41.89  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961  128 PHTQDNCYRFAGYCLNVSRHTLERDGEPIKLTRAEYEMLVAFVTNPGEILSRERLLRMLSARRvenPDLRTVDVLIRRLR 207
Cdd:PRK07239 277 PLRRARTLRAAGHVLEIRGHAVVVDGEVKPLSPAPMALLRALAARPGRVVSREDLLAALPGGG---TDEHAVETAVARLR 353

                         90       100
                 ....*....|....*....|..
gi 16128961  208 HKLSADLLV-TQHGEGYFLAAD 228
Cdd:PRK07239 354 TALGDPKLVqTVVKRGYRLAVD 375
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
1-102 1.86e-04

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 41.38  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    1 MPHHIVIVEDEPVTQARLQSYF-TQEGYTVSVTAS-GAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIIL 78
Cdd:PRK10403   5 TPFQVLIVDDHPLMRRGVRQLLeLDPGFEVVAEAGdGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQII 84

                         90       100
                 ....*....|....*....|....*
gi 16128961   79 VTGRSDRIDRIVGL-EMGADDYVTK 102
Cdd:PRK10403  85 ILTVSDASSDVFALiDAGADGYLLK 109
PRK10610 PRK10610
chemotaxis protein CheY;
42-104 5.38e-04

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 38.80  E-value: 5.38e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16128961   42 MQNQSVDLILLDINLPDENGLMLTRALRER---STVGIILVTGRSDRIDRIVGLEMGADDYVTKPL 104
Cdd:PRK10610  46 LQAGGFGFVISDWNMPNMDGLELLKTIRADgamSALPVLMVTAEAKKENIIAAAQAGASGYVVKPF 111
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
5-103 6.64e-04

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 39.86  E-value: 6.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    5 IVIVEDEPVTQARLQSYF-TQEGYTVSVTAS-GAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIILVTGR 82
Cdd:PRK12555   3 IGIVNDSPLAVEALRRALaRDPDHEVVWVATdGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERPCPILIVTSL 82

                         90       100
                 ....*....|....*....|...
gi 16128961   83 SDRIDRIV--GLEMGADDYVTKP 103
Cdd:PRK12555  83 TERNASRVfeAMGAGALDAVDTP 105
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 4-104 9.68e-04

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 37.90  E-value: 9.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTqEGYTVSVTASGAGLR--EIMQNQSVDLILLDINLPDENGLMLTRALRERS-TVGIILVT 80
Cdd:cd17593   2 KVLICDDSSMARKQLARALP-ADWDVEITFAENGEEalEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQlETKVIVVS 80

                        90       100
                ....*....|....*....|....*.
gi 16128961  81 G--RSDRIDRIvgLEMGADDYVTKPL 104
Cdd:cd17593  81 GdvQPEAKERV--LELGALAFLKKPF 104
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
2-117 9.70e-04

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 39.09  E-value: 9.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    2 PHHIVIVEDEPVTQARLQsYFTQEGYTVSVTASGAGLREI---MQNQSVDLILLDINLPDENGLMLTRALRE-RSTVGII 77
Cdd:PRK09935   3 PASVIIMDTHPIIRMSIE-VLLQKNSELQIVLKTDDYRITidyLRTRPVDLIIMDIDLPGTDGFTFLKRIKQiQSTVKVL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 16128961   78 LVTGRSDRIDRIVGLEMGADDYVTKPLELRELVVRVKNLL 117
Cdd:PRK09935  82 FLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMIL 121
PRK15369 PRK15369
two component system response regulator;
48-102 1.11e-03

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 38.91  E-value: 1.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 16128961   48 DLILLDINLPDENGLMLTRALRER-STVGIILVTGRSDRIDRIVGLEMGADDYVTK 102
Cdd:PRK15369  51 DIVILDLGLPGMNGLDVIPQLHQRwPAMNILVLTARQEEHMASRTLAAGALGYVLK 106
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 5-70 1.81e-03

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 39.12  E-value: 1.81e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16128961    5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQN-QSVDLILLDINLPDENGLMLTRALRE 70
Cdd:PRK11466 684 LLLIEDNPLTQRITAEMLNTSGAQVVAVGNAAQALETLQNsEPFAAALVDFDLPDYDGITLARQLAQ 750
REC_1_GGDEF cd19921
first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 4-102 4.32e-03

first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the first REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381148 [Multi-domain]  Cd Length: 115  Bit Score: 36.00  E-value: 4.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   4 HIVIVEDEPVTQARLQSYFTQE-GYTVSVTASGAGLREIM-QNQSVDLILLDINLPD-ENGLMLTRALrERSTVGIILvT 80
Cdd:cd19921   1 KVLIVEDSKTFSKVLKHLIAQElGLEVDVAETLAEAKALLeEGDDYFAALVDLNLPDaPNGEAVDLVL-EKGIPVIVL-T 78

                        90       100
                ....*....|....*....|..
gi 16128961  81 GRSDRIDRIVGLEMGADDYVTK 102
Cdd:cd19921  79 GSFDEDKRETLLSKGVVDYVLK 100
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-116 4.95e-03

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 37.44  E-value: 4.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961    1 MPHHIVIVEDEPVTQARLQSYFTQE-GYTVSVTAS-GAGLREIMQNQSVDLILLDINLPDENGLMLTRALRERSTVGIIL 78
Cdd:PRK00742   2 MKIRVLVVDDSAFMRRLISEILNSDpDIEVVGTAPdGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRPTPVVM 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 16128961   79 V---TGRSDRIDrIVGLEMGADDYVTKPLE---------LRELVVRVKNL 116
Cdd:PRK00742  82 VsslTERGAEIT-LRALELGAVDFVTKPFLgislgmdeyKEELAEKVRAA 130
REC_RitR-like cd19922
receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus ...
 5-113 6.78e-03

receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus pneumoniae RitR (Repressor of iron transport Regulator, formerly RR489) is an orphan two-component signal transduction response regulator that is required for lung pathogenicity. It acts to repress iron uptake via binding the pneumococcal iron uptake (Piu) transporter promoter. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. However, members of this family do not contain the phosphorylatable aspartic acid residue and are phosphorylation-independent.


Pssm-ID: 381149 [Multi-domain]  Cd Length: 110  Bit Score: 35.15  E-value: 6.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128961   5 IVIVEDEPVTQARLQSYFTQEGYTVSVTASGAGLREIMQNQSVDLILLDINLPDENGLMLTRAL-RERSTVGIILVTGRS 83
Cdd:cd19922   1 ILLLEKERNLAHFLSLELQKEGYRVDLVETGQEALSLALETDYDLILLNVNLSDMSAQDFAEKLsRIKPASVIIVLDHWE 80

                        90       100       110
                ....*....|....*....|....*....|
gi 16128961  84 DRIDRIVGLEMGADDYVTKPLELRELVVRV 113
Cdd:cd19922  81 DLQEELEEVQRFAVSYVVKPVLISNLVDKI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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