|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05365 |
PRK05365 |
malonic semialdehyde reductase; Provisional |
2-196 |
2.70e-131 |
|
malonic semialdehyde reductase; Provisional
Pssm-ID: 180040 [Multi-domain] Cd Length: 195 Bit Score: 366.06 E-value: 2.70e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 2 NEAVSPGALSTLFTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSGNLQKTLTA 81
Cdd:PRK05365 1 SEALDDAALDQLFTEARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPALSEGNLAKTLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 82 PVTAIVAWDSEFYERLPLLFPHGDARSWFTSSPQLAEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTG 161
Cdd:PRK05365 81 PVTAIVAYDTEFHEHLPKLFPHADARSWFAGNPALAEETAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAG 160
|
170 180 190
....*....|....*....|....*....|....*
gi 16128974 162 STLKSNLLINIGYGDSSKLYARLPRLSFEEACGLL 196
Cdd:PRK05365 161 TTWKSNFLVNIGYGDPAKLFPRLPRLSFDEACRIL 195
|
|
| RutE-like |
cd02148 |
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ... |
9-193 |
1.68e-121 |
|
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.
Pssm-ID: 380323 [Multi-domain] Cd Length: 186 Bit Score: 341.16 E-value: 1.68e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 9 ALSTLFTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSGNLQKTLTAPVTAIVA 88
Cdd:cd02148 1 ALDQLFTEARTHNAWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPHLSEGNREKTMAAPVTAILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 89 WDSEFYERLPLLFPHGDARSWFTSS-PQLAEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTGSTLKSN 167
Cdd:cd02148 81 YDTEFYEHLPRLFPHGDARSWFFGSgPARAEETAFRNASLQAAYFILAARALGLDCGPMSGFDAAGVDAEFFAGTRWKSN 160
|
170 180
....*....|....*....|....*.
gi 16128974 168 LLINIGYGDSSKLYARLPRLSFEEAC 193
Cdd:cd02148 161 LVVNLGYGDPSKLFPRLPRLDFDEAC 186
|
|
| NfnB |
COG0778 |
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ... |
10-193 |
5.22e-38 |
|
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation
Pssm-ID: 440541 [Multi-domain] Cd Length: 163 Bit Score: 128.82 E-value: 5.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 10 LSTLFTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSGNLQKTLTAPVTAIVAW 89
Cdd:COG0778 1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALAEANQEWVADAPVLIVVCA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 90 DSEFYERLPllfphgdarswftsspqlaEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTGSTLKSNLL 169
Cdd:COG0778 81 DPDRSEKVP-------------------ERYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEKVRELLGLPEGEEPVAL 141
|
170 180
....*....|....*....|....
gi 16128974 170 INIGYGDsSKLYARlPRLSFEEAC 193
Cdd:COG0778 142 LALGYPA-EELNPR-PRKPLEEVV 163
|
|
| Nitroreductase |
pfam00881 |
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ... |
18-174 |
6.52e-15 |
|
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.
Pssm-ID: 425926 [Multi-domain] Cd Length: 168 Bit Score: 68.96 E-value: 6.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 18 RTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSGNLQKT------LTAPVTAIVAWDS 91
Cdd:pfam00881 5 RSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPaaalllLLRRDANLKLLLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 92 EFYERLP-LLFPHGDARSWFTSSPQLAEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTGSTLKSNLLI 170
Cdd:pfam00881 85 DFLRGAPvLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELLGLPDDERLVGLI 164
|
....
gi 16128974 171 NIGY 174
Cdd:pfam00881 165 AVGY 168
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05365 |
PRK05365 |
malonic semialdehyde reductase; Provisional |
2-196 |
2.70e-131 |
|
malonic semialdehyde reductase; Provisional
Pssm-ID: 180040 [Multi-domain] Cd Length: 195 Bit Score: 366.06 E-value: 2.70e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 2 NEAVSPGALSTLFTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSGNLQKTLTA 81
Cdd:PRK05365 1 SEALDDAALDQLFTEARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPALSEGNLAKTLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 82 PVTAIVAWDSEFYERLPLLFPHGDARSWFTSSPQLAEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTG 161
Cdd:PRK05365 81 PVTAIVAYDTEFHEHLPKLFPHADARSWFAGNPALAEETAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAG 160
|
170 180 190
....*....|....*....|....*....|....*
gi 16128974 162 STLKSNLLINIGYGDSSKLYARLPRLSFEEACGLL 196
Cdd:PRK05365 161 TTWKSNFLVNIGYGDPAKLFPRLPRLSFDEACRIL 195
|
|
| RutE-like |
cd02148 |
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ... |
9-193 |
1.68e-121 |
|
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.
Pssm-ID: 380323 [Multi-domain] Cd Length: 186 Bit Score: 341.16 E-value: 1.68e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 9 ALSTLFTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSGNLQKTLTAPVTAIVA 88
Cdd:cd02148 1 ALDQLFTEARTHNAWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPHLSEGNREKTMAAPVTAILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 89 WDSEFYERLPLLFPHGDARSWFTSS-PQLAEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTGSTLKSN 167
Cdd:cd02148 81 YDTEFYEHLPRLFPHGDARSWFFGSgPARAEETAFRNASLQAAYFILAARALGLDCGPMSGFDAAGVDAEFFAGTRWKSN 160
|
170 180
....*....|....*....|....*.
gi 16128974 168 LLINIGYGDSSKLYARLPRLSFEEAC 193
Cdd:cd02148 161 LVVNLGYGDPSKLFPRLPRLDFDEAC 186
|
|
| NfnB |
COG0778 |
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ... |
10-193 |
5.22e-38 |
|
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation
Pssm-ID: 440541 [Multi-domain] Cd Length: 163 Bit Score: 128.82 E-value: 5.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 10 LSTLFTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSGNLQKTLTAPVTAIVAW 89
Cdd:COG0778 1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALAEANQEWVADAPVLIVVCA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 90 DSEFYERLPllfphgdarswftsspqlaEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTGSTLKSNLL 169
Cdd:COG0778 81 DPDRSEKVP-------------------ERYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEKVRELLGLPEGEEPVAL 141
|
170 180
....*....|....*....|....
gi 16128974 170 INIGYGDsSKLYARlPRLSFEEAC 193
Cdd:COG0778 142 LALGYPA-EELNPR-PRKPLEEVV 163
|
|
| Nitroreductase |
pfam00881 |
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ... |
18-174 |
6.52e-15 |
|
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.
Pssm-ID: 425926 [Multi-domain] Cd Length: 168 Bit Score: 68.96 E-value: 6.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 18 RTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSGNLQKT------LTAPVTAIVAWDS 91
Cdd:pfam00881 5 RSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPaaalllLLRRDANLKLLLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 92 EFYERLP-LLFPHGDARSWFTSSPQLAEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTGSTLKSNLLI 170
Cdd:pfam00881 85 DFLRGAPvLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELLGLPDDERLVGLI 164
|
....
gi 16128974 171 NIGY 174
Cdd:pfam00881 165 AVGY 168
|
|
| nitroreductase |
cd03370 |
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ... |
23-177 |
1.55e-13 |
|
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380327 [Multi-domain] Cd Length: 191 Bit Score: 65.80 E-value: 1.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 23 WRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPAlssGNLQKTLT-APVTAIVAWDSEfyERLPLL- 100
Cdd:cd03370 14 YTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAA---AYGQAQVTsAPAVIVIYSDME--DALANLe 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 101 -FPH----GDARSWFTSSPQlaeeTAFRNSSMQA-------------AYLIVACRALGLDTGPMSGFDRQHVDDAFFTGS 162
Cdd:cd03370 89 eTIHpglsEERRQREAAGLR----GAFGKMSVEQrgqwglaqanialGFLLLAAQSLGYDTSPMLGFDPEKVKALLGLPE 164
|
170
....*....|....*
gi 16128974 163 TLKSNLLINIGYGDS 177
Cdd:cd03370 165 HVTIAALVALGKPAE 179
|
|
| Nitro_FMN_reductase |
cd02062 |
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
14-174 |
3.41e-13 |
|
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.
Pssm-ID: 380311 [Multi-domain] Cd Length: 139 Bit Score: 63.86 E-value: 3.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 14 FTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRpALSSGNLQKTLTAPVTAIVAWDSEF 93
Cdd:cd02062 1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLA-KLAAPNQKFIAGAPVVIVVVADPDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 94 YerlpllfphgdarswftsspqlaEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDR--QHVDDAFFTGSTLKSNLLIN 171
Cdd:cd02062 80 S-----------------------RPWALEDAGAAAQNLLLAAAALGLGSCWIGGFDFreDKVRELLGIPENLRPVALIA 136
|
...
gi 16128974 172 IGY 174
Cdd:cd02062 137 IGY 139
|
|
| MhqN-like |
cd02137 |
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ... |
27-191 |
3.96e-13 |
|
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380314 [Multi-domain] Cd Length: 147 Bit Score: 63.80 E-value: 3.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 27 PVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPAlsSGNLQKTLTAPVTAIVAWDsefyerlpllfphgda 106
Cdd:cd02137 18 KIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEA--AYNQPQVTTASAVILVLGD---------------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 107 rswftsspqlaeetafRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTGSTLKSNLLINIGYGDssKLYARLPR 186
Cdd:cd02137 80 ----------------LNAGLAAMNLMLAAKAKGYDTCPMGGFDKEKVAELLNLPDRYVPVLLIAIGKAA--DKAPRSGR 141
|
....*
gi 16128974 187 LSFEE 191
Cdd:cd02137 142 LPVDE 146
|
|
| NfsB-like |
cd02149 |
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ... |
27-174 |
1.48e-07 |
|
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.
Pssm-ID: 380324 [Multi-domain] Cd Length: 156 Bit Score: 48.79 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 27 PVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPAlSSGNLQKTLTAPVTAIVAWDSEfyerlpllfphgda 106
Cdd:cd02149 20 KISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPA-AWFNQPQIKDASHVVVFLAKKD-------------- 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16128974 107 rsWftSSPQlaeetafrnSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFF-TGSTLKSNLLINIGY 174
Cdd:cd02149 85 --W--SAKQ---------TYIALGNMLLAAAMLGIDSCPIEGFDPAKLDEILGlDEKGYKISVMVAFGY 140
|
|
| PRK11053 |
PRK11053 |
oxygen-insensitive NAD(P)H nitroreductase; |
28-191 |
1.02e-05 |
|
oxygen-insensitive NAD(P)H nitroreductase;
Pssm-ID: 182929 [Multi-domain] Cd Length: 217 Bit Score: 44.58 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 28 VSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSG---NLQKTLTAPVTAI----VAWDSEFYERLpll 100
Cdd:PRK11053 22 LPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEGKARIAKAAAGNyafNERKILDASHVVVfcakTDMDDAYLELV--- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 101 fphgdarswftsspqLAEETA---FRNSSMQAA---------------------------YLIV-----ACRALGLDTGP 145
Cdd:PRK11053 99 ---------------LEQEDAdgrFATEEAKAAqdkgrrffadmhrkelkdlqhwmekqvYLALgnlllGAAALGIDATP 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 16128974 146 MSGFDRQHVDDAF-FTGSTLKSNLLINIGYGDSSKLYARLP--RLSFEE 191
Cdd:PRK11053 164 IEGFDAAILDAEFgLREKGLTSSVVVPLGYHSEEDFNAKLPksRLPQET 212
|
|
| TdsD-like |
cd02138 |
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ... |
25-186 |
2.71e-05 |
|
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380315 [Multi-domain] Cd Length: 174 Bit Score: 42.92 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 25 ETPVSDETLREIYALMKWGPTSANCSPAR-IVFTRTAEGKERLRPALSSGNLQKTLTAPVTAIVAWDSEFyerlpllfPH 103
Cdd:cd02138 13 PEPISEEDLLSLFEAARWAPSCFNEQPWRfVVARRDTEAFEKLLDLLAEGNQSWAKNAPVLIVVLAKTEF--------DH 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 104 GDARSwftsspqlaeETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTGSTLKSNLLINIGY-GDSSKLYA 182
Cdd:cd02138 85 NGKPN----------RYALFDTGAAVANLALQATALGLVVHQMAGFDPEKAKEALGIPDEYEPITMIAIGYpGDPESLPE 154
|
....
gi 16128974 183 RLPR 186
Cdd:cd02138 155 KLLE 158
|
|
| PnbA_NfnB-like |
cd02136 |
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ... |
24-191 |
7.78e-04 |
|
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.
Pssm-ID: 380313 [Multi-domain] Cd Length: 152 Bit Score: 38.34 E-value: 7.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 24 RETPVSDETLREIYALMKWGPTSANCSPARIVFTrTAEGKERLRpalssgnlQKTLTAPVTAIVawdsefyerlpllfpH 103
Cdd:cd02136 12 KDKPVPKETIEKILEAARRAPSGKNTQPWRVYVV-TGKARERLK--------KAFFGAPVALFL---------------T 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128974 104 GDARSWFTSspqlaeetaFRNSSMQAAYLIVACRALGLDTGPMSGFDRQH--VDDAFFTGSTLKSNLLINIGYGDSSKLY 181
Cdd:cd02136 68 MDKVLGPWS---------WFDLGAFLQNLMLAAHALGLGTCPQGALAGYPdvVRKELGIPDDEELVCGIALGYPDPDAPV 138
|
170
....*....|..
gi 16128974 182 ARL--PRLSFEE 191
Cdd:cd02136 139 NQFrtPREPLEE 150
|
|
| nitroreductase |
cd20609 |
nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
25-92 |
4.45e-03 |
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nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.
Pssm-ID: 380330 [Multi-domain] Cd Length: 145 Bit Score: 35.83 E-value: 4.45e-03
10 20 30 40 50 60
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gi 16128974 25 ETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSgnlqkTLTAPVTAIVAWDSE 92
Cdd:cd20609 17 DKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKATPR-----FFGAPLVIVVCYDKD 79
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