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Conserved domains on  [gi|16129004|ref|NP_415559|]
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curlin, minor subunit [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

curlin minor subunit CsgB( domain architecture ID 11484578)

curlin minor subunit CsgB is required for CsgA polymerization on the cell surface

Gene Symbol:  csgB
Gene Ontology:  GO:0098775

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
csgB PRK10101
curlin minor subunit CsgB; Provisional
1-151 1.44e-87

curlin minor subunit CsgB; Provisional


:

Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 252.09  E-value: 1.44e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129004    1 MKNKLLFMMLTILGAPGIAAAAGYDLANSEYNFAVNELSKSSFNQAAIIGQAGTNNSAQLRQGGSKLLAVVAQEGSSNRA 80
Cdd:PRK10101   1 MKNKLLFMMLTILGAPGIAAAAGYDLANSEYNFAVNELSKSSFNQAAIIGQAGTNNSAQVRQGGSKLLAVVSQEGSSNRA 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16129004   81 KIDQTGDYNLAYIDQAGSANDASISQGAYGNTAMIIQKGSGNKANITQYGTQKTAIVVQRQSQMAIRVTQR 151
Cdd:PRK10101  81 KIDQTGDYNLAYIDQTGSANDASISQGAYGNTAMIIQKGSGNKANITQYGTQKTAVVVQRQSQMAIRVTQR 151
 
Name Accession Description Interval E-value
csgB PRK10101
curlin minor subunit CsgB; Provisional
1-151 1.44e-87

curlin minor subunit CsgB; Provisional


Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 252.09  E-value: 1.44e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129004    1 MKNKLLFMMLTILGAPGIAAAAGYDLANSEYNFAVNELSKSSFNQAAIIGQAGTNNSAQLRQGGSKLLAVVAQEGSSNRA 80
Cdd:PRK10101   1 MKNKLLFMMLTILGAPGIAAAAGYDLANSEYNFAVNELSKSSFNQAAIIGQAGTNNSAQVRQGGSKLLAVVSQEGSSNRA 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16129004   81 KIDQTGDYNLAYIDQAGSANDASISQGAYGNTAMIIQKGSGNKANITQYGTQKTAIVVQRQSQMAIRVTQR 151
Cdd:PRK10101  81 KIDQTGDYNLAYIDQTGSANDASISQGAYGNTAMIIQKGSGNKANITQYGTQKTAVVVQRQSQMAIRVTQR 151
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
97-130 6.14e-06

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 40.91  E-value: 6.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 16129004    97 GSANDASISQGAYGNTAMIIQKGSGNKANITQYG 130
Cdd:pfam07012   1 GDDNTADITQSGDNNSAYVGQSGSNNDATVTQTG 34
 
Name Accession Description Interval E-value
csgB PRK10101
curlin minor subunit CsgB; Provisional
1-151 1.44e-87

curlin minor subunit CsgB; Provisional


Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 252.09  E-value: 1.44e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129004    1 MKNKLLFMMLTILGAPGIAAAAGYDLANSEYNFAVNELSKSSFNQAAIIGQAGTNNSAQLRQGGSKLLAVVAQEGSSNRA 80
Cdd:PRK10101   1 MKNKLLFMMLTILGAPGIAAAAGYDLANSEYNFAVNELSKSSFNQAAIIGQAGTNNSAQVRQGGSKLLAVVSQEGSSNRA 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16129004   81 KIDQTGDYNLAYIDQAGSANDASISQGAYGNTAMIIQKGSGNKANITQYGTQKTAIVVQRQSQMAIRVTQR 151
Cdd:PRK10101  81 KIDQTGDYNLAYIDQTGSANDASISQGAYGNTAMIIQKGSGNKANITQYGTQKTAVVVQRQSQMAIRVTQR 151
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
97-130 6.14e-06

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 40.91  E-value: 6.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 16129004    97 GSANDASISQGAYGNTAMIIQKGSGNKANITQYG 130
Cdd:pfam07012   1 GDDNTADITQSGDNNSAYVGQSGSNNDATVTQTG 34
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
75-106 9.83e-06

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 40.14  E-value: 9.83e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 16129004    75 GSSNRAKIDQTGDYNLAYIDQAGSANDASISQ 106
Cdd:pfam07012   1 GDDNTADITQSGDNNSAYVGQSGSNNDATVTQ 32
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
53-86 3.85e-05

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 38.60  E-value: 3.85e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 16129004    53 GTNNSAQLRQGGSKLLAVVAQEGSSNRAKIDQTG 86
Cdd:pfam07012   1 GDDNTADITQSGDNNSAYVGQSGSNNDATVTQTG 34
csgA PRK10051
major curlin subunit CsgA;
49-129 2.45e-04

major curlin subunit CsgA;


Pssm-ID: 182211 [Multi-domain]  Cd Length: 151  Bit Score: 39.07  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129004   49 IGQAGTNNSAQLRQGGSKLLAVVAQEGSSNRAKIDQ-TGDYNLAYIDQAGSANDASISQGAYGNTAMIIQKGSGNKANIT 127
Cdd:PRK10051  70 ITQHGGGNGADVGQGSDDSSIDLTQNGFGNSATLDQwNGKNSDMTVKQFGGGNGAAVDQTASNSSVNVTQVGFGNNATAH 149

                 ..
gi 16129004  128 QY 129
Cdd:PRK10051 150 QY 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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